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Tony Yaksh

TitleRecall Faculty
InstitutionUniversity of California San Diego
DepartmentAnesthesiology
Address9500 Gilman Drive #0818
La Jolla CA 92093
Phone619-543-3597
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.Purdue University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Reversal of preexisting neuropathic pain by spinal delivery of AIBP
    NIH/NINDS R21NS104769Aug 1, 2018 - Jul 31, 2020
    Role: Co-Principal Investigator
    AIBP and regulation of neuropathic pain
    NIH/NINDS R01NS102432Aug 15, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Sex, Stress and Immunity in the Acute to Chronic Pain Transition
    NIH/NINDS R01NS099338Dec 15, 2016 - Nov 30, 2021
    Role: Principal Investigator
    Construction and Analysis of BoNT derivatives as Pain Specific Inhibitors
    NIH/NIAID R21AI113580Aug 7, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Discovery of novel small molecule analgesics
    NIH/NINDS R41NS086244May 15, 2014 - Apr 30, 2015
    Role: Principal Investigator
    Proteolysis of Myelin as a Source of Neuropathic Pain
    NIH/NIDCR R01DE022757Jul 30, 2012 - Jun 30, 2017
    Role: Principal Investigator
    The role of selective brain penetrating GRPR antagonists in pruritis.
    NIH/NINDS R21NS077348Sep 30, 2011 - Dec 30, 2013
    Role: Principal Investigator
    Pain Mechanisms and the Development of Analgesics
    NIH/NIDA R13DA021484Mar 1, 2006 - Feb 28, 2007
    Role: Principal Investigator
    Characterization of Toxicity with Spinal Opiates
    NIH/NIDA R01DA015353Jul 1, 2002 - Jun 30, 2018
    Role: Principal Investigator
    Spinal Galanin and its Receptors in Pain Processing
    NIH/NINDS R01NS041954Jun 1, 2002 - May 31, 2006
    Role: Principal Investigator
    Neurobiology of Pain
    NIH/NINDS T32NS007407Jul 1, 1997 - Jun 30, 2007
    Role: Principal Investigator
    PRECLINICAL TOXICOLOGY STUDIES OF NMDA ANTAGONISTS
    NIH/NINDS R01NS033846Aug 1, 1994 - Jul 31, 1998
    Role: Principal Investigator
    NEW MODALITIES FOR TREATMENT OF PAIN AND DRUG ABUSE
    NIH P01DA006284Sep 30, 1989 - Mar 31, 2016
    Role: Co-Investigator
    Pain Evoked Release of Amino Acids and Prostanoids
    NIH/NINDS R37NS016541Sep 1, 1988 - Feb 28, 2013
    Role: Principal Investigator
    PEPTIDE RELEASE FROM PERIPHERAL TERMINALS OF AFFERENTS
    NIH/NIAID R01AI026249Apr 1, 1988 - Mar 31, 1992
    Role: Principal Investigator
    The Pharmacology of Spinal Analgesics
    NIH/NIDA R01DA002110Jul 1, 1983 - Jan 31, 2015
    Role: Principal Investigator
    SPINAL PHARMACOLOGY OF BLADDER FUNCTION
    NIH/NINDS R01NS019650Jul 1, 1983 - Jun 30, 1986
    Role: Principal Investigator
    PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    NIH/NINDS R01NS016541Jul 1, 1980 - Dec 31, 2005
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2019
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. Inhibition of Spinal 15-LOX-1 Attenuates TLR4-Dependent, NSAID-Unresponsive Hyperalgesia in Male Rats. Pain. 2018 Aug 16. PMID: 30130298.
      View in: PubMed
    2. Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K. Targeting Toll-like Receptor-4 (TLR4) - Emerging Therapeutic Target for Persistent Pain States. Pain. 2018 Jun 07. PMID: 29889119.
      View in: PubMed
    3. Woller SA, Choi SH, An EJ, Low H, Schneider DA, Ramachandran R, Kim J, Bae YS, Sviridov D, Corr M, Yaksh TL, Miller YI. Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States. Cell Rep. 2018 May 29; 23(9):2667-2677. PMID: 29847797.
      View in: PubMed
    4. Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH. Transition to chronic pain: opportunities for novel therapeutics. Nat Rev Neurosci. 2018 May 15. PMID: 29765159.
      View in: PubMed
    5. Yaksh TL, Di Nardo A. Complexity of systems and actions underlying neurogenic inflammation. Semin Immunopathol. 2018 May; 40(3):225-228. PMID: 29779134.
      View in: PubMed
    6. Ramachandran R, Marino MJ, Paul S, Wang Z, Mascarenhas NL, Pellett S, Johnson EA, DiNardo A, Yaksh TL. A Study and Review of Effects of Botulinum Toxins on Mast Cell Dependent and Independent Pruritus. Toxins (Basel). 2018 Mar 23; 10(4). PMID: 29570628.
      View in: PubMed
    7. Sorkin LS, Eddinger KA, Woller SA, Yaksh TL. Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation. Semin Immunopathol. 2018 Feb 08. PMID: 29423889.
      View in: PubMed
    8. Woller SA, Eddinger KA, Corr M, Yaksh TL. An overview of pathways encoding nociception. Clin Exp Rheumatol. 2018 Jan-Feb; 36(1):172. PMID: 29461960.
      View in: PubMed
    9. Emami A, Tepper J, Short B, Yaksh TL, Bendele AM, Ramani T, Cisternas AF, Chang JH, Mellon RD. Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular. Int J Toxicol. 2018 Jan/Feb; 37(1):4-27. PMID: 29264927.
      View in: PubMed
    10. Hockman TM, Cisternas AF, Jones B, Butt MT, Osborn KG, Steinauer JJ, Malkmus SA, Yaksh TL. Target engagement and histopathology of neuraxial resiniferatoxin in dog. Vet Anaesth Analg. 2018 Mar; 45(2):212-226. PMID: 29361418.
      View in: PubMed
    11. Knezevic NN, Yekkirala A, Yaksh TL. Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics. Anesth Analg. 2017 11; 125(5):1714-1732. PMID: 29049116.
      View in: PubMed
    12. Schmidt-Rondon E, Wang Z, Malkmus SA, Di Nardo A, Hildebrand K, Page L, Yaksh TL. Effects of opioid and nonopioid analgesics on canine wheal formation and cultured human mast cell degranulation. Toxicol Appl Pharmacol. 2018 01 01; 338:54-64. PMID: 29111148.
      View in: PubMed
    13. Woller SA, Eddinger KA, Corr M, Yaksh TL. An overview of pathways encoding nociception. Clin Exp Rheumatol. 2017 Sep-Oct; 35 Suppl 107(5):40-46. PMID: 28967373.
      View in: PubMed
    14. Mamet J, Yeomans DC, Yaksh TL, Manning DC, Harris S. Editor's Highlight: Formulation and Toxicology Evaluation of the Intrathecal AYX1 DNA-Decoy in Sprague Dawley Rats. Toxicol Sci. 2017 Sep 01; 159(1):76-85. PMID: 28903493.
      View in: PubMed
    15. Bert RJ, Hayek SM, Yaksh TL. Modeling Spinal Intrathecal Drug Distribution: The Challenge of Defining and Predicting Cerebrospinal Fluid Dynamics. Anesth Analg. 2017 05; 124(5):1403-1406. PMID: 28426585.
      View in: PubMed
    16. Yaksh TL, Schwarcz R, Snodgrass HR. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct; 18(10):1184-1196. PMID: 28428091.
      View in: PubMed
    17. Rijsdijk M, Agalave NM, van Wijck AJM, Kalkman CJ, Ramachandran R, Baharpoor A, Svensson CI, Yaksh TL. Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model. Scand J Pain. 2017 Jul; 16:1-9. PMID: 28850381.
      View in: PubMed
    18. Deer TR, Pope JE, Hayek SM, Lamer TJ, Veizi IE, Erdek M, Wallace MS, Grider JS, Levy RM, Prager J, Rosen SM, Saulino M, Yaksh TL, De Andrés JA, Abejon Gonzalez D, Vesper J, Schu S, Simpson B, Mekhail N. The Polyanalgesic Consensus Conference (PACC): Recommendations for Intrathecal Drug Delivery: Guidance for Improving Safety and Mitigating Risks. Neuromodulation. 2017 Feb; 20(2):155-176. PMID: 28042914.
      View in: PubMed
    19. Deer TR, Pope JE, Hayek SM, Bux A, Buchser E, Eldabe S, De Andrés JA, Erdek M, Patin D, Grider JS, Doleys DM, Jacobs MS, Yaksh TL, Poree L, Wallace MS, Prager J, Rauck R, DeLeon O, Diwan S, Falowski SM, Gazelka HM, Kim P, Leong M, Levy RM, McDowell G, McRoberts P, Naidu R, Narouze S, Perruchoud C, Rosen SM, Rosenberg WS, Saulino M, Staats P, Stearns LJ, Willis D, Krames E, Huntoon M, Mekhail N. The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines. Neuromodulation. 2017 02; 20(2):96-132. PMID: 28042904.
      View in: PubMed
    20. Mamet J, Harris S, Klukinov M, Yeomans DC, Donahue RR, Taylor BK, Eddinger K, Yaksh T, Manning DC. Pharmacology, pharmacokinetics, and metabolism of the DNA-decoy AYX1 for the prevention of acute and chronic post-surgical pain. Mol Pain. 2017 01; 13:1744806917703112. PMID: 28394696.
      View in: PubMed
    21. Yaksh TL, Fisher CJ, Hockman TM, Wiese AJ. Current and Future Issues in the Development of Spinal Agents for the Management of Pain. Curr Neuropharmacol. 2017; 15(2):232-259. PMID: 26861470.
      View in: PubMed
    22. Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi SK, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev VI. Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain. Brain Behav Immun. 2017 Feb; 60:282-292. PMID: 27833045.
      View in: PubMed
    23. Eisenach JC, Yaksh TL. Ethical Concerns Regarding Human Study. CNS Neurosci Ther. 2016 10; 22(10):866. PMID: 27577599.
      View in: PubMed
    24. Veizi IE, Hayek SM, Hanes M, Galica R, Katta S, Yaksh T. Primary Hydromorphone-Related Intrathecal Catheter Tip Granulomas: Is There a Role for Dose and Concentration? Neuromodulation. 2016 Oct; 19(7):760-769. PMID: 27505059.
      View in: PubMed
    25. Eddinger KA, Rondon ES, Shubayev VI, Grafe MR, Scadeng M, Hildebrand KR, Page LM, Malkmus SA, Steinauer JJ, Yaksh TL. Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation. Anesthesiology. 2016 08; 125(2):378-94. PMID: 27272672.
      View in: PubMed
    26. Shubayev VI, Strongin AY, Yaksh TL. Role of myelin auto-antigens in pain: a female connection. Neural Regen Res. 2016 Jun; 11(6):890-1. PMID: 27482203; PMCID: PMC4962572.
    27. Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R. Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt. Eur J Neurosci. 2016 07; 44(1):1714-22. PMID: 27108664.
      View in: PubMed
    28. Merrick J, Lane B, Sebree T, Yaksh T, O'Neill C, Banks SL. Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid. Cannabis Cannabinoid Res. 2016; 1(1):102-112. PMID: 28861485.
      View in: PubMed
    29. Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Isseroff RR, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL. Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state. Brain Behav Immun. 2016 Aug; 56:271-80. PMID: 27044335; PMCID: PMC4917460 [Available on 08/01/17].
    30. Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev VI. Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia. Brain Behav Immun. 2016 Aug; 56:378-89. PMID: 26970355; PMCID: PMC4917441 [Available on 08/01/17].
    31. Podvin S, Yaksh T, Hook V. The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annu Rev Pharmacol Toxicol. 2016; 56:511-33. PMID: 26738478; PMCID: PMC4902163 [Available on 01/01/17].
    32. Rijsdijk M, Svensson CI, Wijck AJ, Kalkman CJ, Yaksh TL. Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models. Scand J Pain. 2016 Jan; 10:90-102. PMID: 28361779.
      View in: PubMed
    33. Pellett S, Yaksh TL, Ramachandran R. Current status and future directions of botulinum neurotoxins for targeting pain processing. Toxins (Basel). 2015 Nov 04; 7(11):4519-63. PMID: 26556371; PMCID: PMC4663519.
    34. Park HJ, Marino MJ, Rondon ES, Xu Q, Yaksh TL. The effects of intraplantar and intrathecal botulinum toxin type B on tactile allodynia in mono and polyneuropathy in the mouse. Anesth Analg. 2015 Jul; 121(1):229-38. PMID: 26039418.
      View in: PubMed
    35. Yaksh TL, Woller SA, Ramachandran R, Sorkin LS. The search for novel analgesics: targets and mechanisms. F1000Prime Rep. 2015; 7:56. PMID: 26097729; PMCID: PMC4447049.
    36. Ramachandran R, Lam C, Yaksh TL. Botulinum toxin in migraine: Role of transport in trigemino-somatic and trigemino-vascular afferents. Neurobiol Dis. 2015 Jul; 79:111-22. PMID: 25958249; PMCID: PMC4458441.
    37. Ramachandran R, Yaksh TL. Therapeutic use of botulinum toxin in migraine: mechanisms of action. Br J Pharmacol. 2014 Sep; 171(18):4177-92. PMID: 24819339; PMCID: PMC4241086.
    38. Rijsdijk M, van Wijck AJ, Kalkman CJ, Yaksh TL. The effects of glucocorticoids on neuropathic pain: a review with emphasis on intrathecal methylprednisolone acetate delivery. Anesth Analg. 2014 May; 118(5):1097-112. PMID: 24781577.
      View in: PubMed
    39. Yaksh TL. TRPV1 expression regulation… A further step in defining its biology: commentary for K. Zavala et al. "The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons" [Neurosci. Lett. (2014) doi:10.1016/j.neulet.2014.01.021]. Neurosci Lett. 2014 Aug 22; 578:209-10. PMID: 24769421.
      View in: PubMed
    40. Yaksh TL, Hobo S, Peters C, Osborn KG, Richter PJ, Rossi SS, Grafe MR, Eisenach JC. Preclinical toxicity screening of intrathecal oxytocin in rats and dogs. Anesthesiology. 2014 Apr; 120(4):951-61. PMID: 24492326.
      View in: PubMed
    41. Leung A, Shukla S, Li E, Duann JR, Yaksh T. Supraspinal characterization of the thermal grill illusion with fMRI. Mol Pain. 2014 Mar 11; 10:18. PMID: 24612493; PMCID: PMC3995740.
    42. Marino MJ, Terashima T, Steinauer JJ, Eddinger KA, Yaksh TL, Xu Q. Botulinum toxin B in the sensory afferent: transmitter release, spinal activation, and pain behavior. Pain. 2014 Apr; 155(4):674-84. PMID: 24333775; PMCID: PMC3960322.
    43. Stokes JA, Cheung J, Eddinger K, Corr M, Yaksh TL. Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. J Neuroinflammation. 2013 Dec 09; 10:148. PMID: 24321498; PMCID: PMC3896749.
    44. Wiese AJ, Rathbun M, Butt MT, Malkmus SA, Richter PJ, Osborn KG, Xu Q, Veesart SL, Steinauer JJ, Higgins D, Lappi DA, Russell B, Yaksh TL. Intrathecal substance P-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation. Anesthesiology. 2013 Nov; 119(5):1163-77. PMID: 24051388.
      View in: PubMed
    45. Park HJ, Stokes JA, Corr M, Yaksh TL. Toll-like receptor signaling regulates cisplatin-induced mechanical allodynia in mice. Cancer Chemother Pharmacol. 2014 Jan; 73(1):25-34. PMID: 24162377; PMCID: PMC3917999.
    46. Mamet J, Klukinov M, Yaksh TL, Malkmus SA, Williams S, Harris S, Manning DC, Taylor BK, Donahue RR, Porreca F, Xie JY, Oyarzo J, Brennan TJ, Subieta A, Schmidt WK, Yeomans DC. Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury. Pain. 2014 Feb; 155(2):322-33. PMID: 24145208.
      View in: PubMed
    47. Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q. Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. J Pharmacol Exp Ther. 2013 Nov; 347(2):258-64. PMID: 23978562; PMCID: PMC3807063.
    48. Nizet V, Yaksh T. Neuroscience: Bacteria get on your nerves. Nature. 2013 Sep 05; 501(7465):43-4. PMID: 23965630.
      View in: PubMed
    49. Takasusuki T, Yamaguchi S, Hamaguchi S, Yaksh TL. Effects of general anesthetics on substance P release and c-Fos expression in the spinal dorsal horn. Anesthesiology. 2013 Aug; 119(2):433-42. PMID: 23708866; PMCID: PMC3788114.
    50. Hamurtekin E, Fitzsimmons BL, Shubayev VI, Grafe MR, Deumens R, Yaksh TL, Walker SM. Evaluation of spinal toxicity and long-term spinal reflex function after intrathecal levobupivaciane in the neonatal rat. Anesthesiology. 2013 Jul; 119(1):142-55. PMID: 23514721; PMCID: PMC3732172.
    51. Terashima T, Xu Q, Yamaguchi S, Yaksh TL. Intrathecal P/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression. Neuropharmacology. 2013 Dec; 75:1-8. PMID: 23810829; PMCID: PMC3865027.
    52. Svensson E, Persson J, Fitzsimmons B, Yaksh TL. Intrathecal neurosteroids and a neurosteroid antagonist: effects on inflammation-evoked thermal hyperalgesia and tactile allodynia. Neurosci Lett. 2013 Aug 26; 548:27-32. PMID: 23707652; PMCID: PMC3761066.
    53. Yaksh TL, Allen JW, Veesart SL, Horais KA, Malkmus SA, Scadeng M, Steinauer JJ, Rossi SS. Role of meningeal mast cells in intrathecal morphine-evoked granuloma formation. Anesthesiology. 2013 Mar; 118(3):664-78. PMID: 23426209; PMCID: PMC3788115.
    54. Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. FASEB J. 2013 May; 27(5):1939-49. PMID: 23382512; PMCID: PMC3633813.
    55. Stokes JA, Corr M, Yaksh TL. Spinal toll-like receptor signaling and nociceptive processing: regulatory balance between TIRAP and TRIF cascades mediated by TNF and IFNß. Pain. 2013 May; 154(5):733-42. PMID: 23489833; PMCID: PMC3622773.
    56. Wahlert A, Funkelstein L, Fitzsimmons B, Yaksh T, Hook V. Spinal astrocytes produce and secrete dynorphin neuropeptides. Neuropeptides. 2013 Apr; 47(2):109-15. PMID: 23290538; PMCID: PMC3606903.
    57. Park HJ, Stokes JA, Pirie E, Skahen J, Shtaerman Y, Yaksh TL. Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. Anesth Analg. 2013 Jan; 116(1):224-31. PMID: 23223118; PMCID: PMC3530135.
    58. Yaksh TL, Steinauer JJ, Veesart SL, Malkmus SA. Alfentanil: correlations between absence of effect upon subcutaneous mast cells and absence of granuloma formation after intrathecal infusion in the dog. Neuromodulation. 2013 Sep-Oct; 16(5):459-66; discussion 466. PMID: 23170763; PMCID: PMC3582801.
    59. Marino M, Huang P, Malkmus S, Robertshaw E, Mac EA, Shatterman Y, Yaksh TL. Development and validation of an automated system for detection and assessment of scratching in the rodent. J Neurosci Methods. 2012 Oct 15; 211(1):1-10. PMID: 22971351; PMCID: PMC3473159.
    60. Deer TR, Levy R, Prager J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, Kumar K, Leong M, Liem L, McDowell GC, Panchal S, Rauck R, Saulino M, Sitzman BT, Staats P, Stanton-Hicks M, Stearns L, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. Polyanalgesic Consensus Conference--2012: recommendations to reduce morbidity and mortality in intrathecal drug delivery in the treatment of chronic pain. Neuromodulation. 2012 Sep-Oct; 15(5):467-82; discussion 482. PMID: 22849581.
      View in: PubMed
    61. Wallace M, Yaksh TL. Characteristics of distribution of morphine and metabolites in cerebrospinal fluid and plasma with chronic intrathecal morphine infusion in humans. Anesth Analg. 2012 Oct; 115(4):797-804. PMID: 22822192; PMCID: PMC3456964.
    62. Lampa J, Westman M, Kadetoff D, Agréus AN, Le Maître E, Gillis-Haegerstrand C, Andersson M, Khademi M, Corr M, Christianson CA, Delaney A, Yaksh TL, Kosek E, Svensson CI. Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12728-33. PMID: 22802629; PMCID: PMC3411968.
    63. Walker SM, Yaksh TL. Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data. Anesth Analg. 2012 Sep; 115(3):638-62. PMID: 22798528; PMCID: PMC4451199.
    64. Yaksh TL, de Kater A, Dean R, Best BM, Miljanich GP. Pharmacokinetic analysis of ziconotide (SNX-111), an intrathecal N-type calcium channel blocking analgesic, delivered by bolus and infusion in the dog. Neuromodulation. 2012 Nov-Dec; 15(6):508-19; discussion 519. PMID: 22748108; PMCID: PMC3514653.
    65. Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, Kumar K, Leong M, Liem L, McDowell GC, Panchal S, Rauck R, Saulino M, Sitzman BT, Staats P, Stanton-Hicks M, Stearns L, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. Polyanalgesic Consensus Conference 2012: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation. 2012 Sep-Oct; 15(5):436-64; discussion 464-6. PMID: 22748024.
      View in: PubMed
    66. Yaksh TL, Ilfeld BM, Wiese AJ. Perineural local anesthetic and adjuvant action: the meaning of an ex vivo data set for efficacy and safety. Reg Anesth Pain Med. 2012 Jul-Aug; 37(4):366-8. PMID: 22660488.
      View in: PubMed
    67. Cohen SP, White RL, Kurihara C, Larkin TM, Chang A, Griffith SR, Gilligan C, Larkin R, Morlando B, Pasquina PF, Yaksh TL, Nguyen C. Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial. Ann Intern Med. 2012 Apr 17; 156(8):551-9. PMID: 22508732.
      View in: PubMed
    68. Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, Kumar K, Leong M, Liem L, McDowell GC, Panchal S, Rauck R, Saulino M, Sitzman BT, Staats P, Stanton-Hicks M, Stearns L, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. Polyanalgesic Consensus Conference--2012: consensus on diagnosis, detection, and treatment of catheter-tip granulomas (inflammatory masses). Neuromodulation. 2012 Sep-Oct; 15(5):483-95; discussion 496. PMID: 22494332.
      View in: PubMed
    69. Deer TR, Prager J, Levy R, Burton A, Buchser E, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs M, Kim P, Kumar K, Leong M, Liem L, McDowell G, Panchal SJ, Rauck R, Saulino M, Staats P, Stanton-Hicks M, Stearns L, Sitzman BT, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. Polyanalgesic Consensus Conference--2012: recommendations on trialing for intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation. 2012 Sep-Oct; 15(5):420-35; discussion 435. PMID: 22494357.
      View in: PubMed
    70. Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6721-6. PMID: 22493235; PMCID: PMC3340022.
    71. Walker SM, Grafe M, Yaksh TL. Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity. Anesth Analg. 2012 Aug; 115(2):450-60. PMID: 22467896; PMCID: PMC4455964.
    72. Rijsdijk M, van Wijck AJ, Kalkman CJ, Meulenhoff PC, Grafe MR, Steinauer J, Yaksh TL. Safety assessment and pharmacokinetics of intrathecal methylprednisolone acetate in dogs. Anesthesiology. 2012 Jan; 116(1):170-81. PMID: 22139590.
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    73. Christianson CA, Corr M, Yaksh TL, Svensson CI. K/BxN serum transfer arthritis as a model of inflammatory joint pain. Methods Mol Biol. 2012; 851:249-60. PMID: 22351097.
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    74. Suhail MS, Christianson C, Koehrn F, Malkmus SA, Mitchell W, Corr M, Yaksh TL. Effects of long term polyarthritis and subsequent NSAID treatment on activity with disassociation of tactile allodynia in the mouse. Neurocomputing. 2012 May 01; 84:47-52. PMID: 22547902.
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    75. Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, Yaksh TL. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain. 2011 Dec; 152(12):2881-91. PMID: 22019135; PMCID: PMC3347973.
    76. Kim HJ, Seol TK, Lee HJ, Yaksh TL, Jun JH. The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats. J Anesth. 2011 Dec; 25(6):884-91. PMID: 21983967.
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    77. Stokes JA, Corr M, Yaksh TL. Transient tactile allodynia following intrathecal puncture in mouse: contributions of Toll-like receptor signaling. Neurosci Lett. 2011 Oct 31; 504(3):215-8. PMID: 21964382; PMCID: PMC3338641.
    78. Xu Q, Yaksh TL. A brief comparison of the pathophysiology of inflammatory versus neuropathic pain. Curr Opin Anaesthesiol. 2011 Aug; 24(4):400-7. PMID: 21659872; PMCID: PMC3290396.
    79. Yaksh TL. Care to wrestle with a Brazilian armed spider? Pain. 2011 Oct; 152(10):2193-5. PMID: 21782344.
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    80. Takasusuki T, Yaksh TL. Regulation of spinal substance p release by intrathecal calcium channel blockade. Anesthesiology. 2011 Jul; 115(1):153-64. PMID: 21577088; PMCID: PMC3360553.
    81. Yaksh TL. Spinal toxins can have persistent adverse effects. Pain Med. 2011 Jul; 12(7):991-2. PMID: 21752177.
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    82. Huang PP, Khan I, Suhail MS, Malkmus S, Yaksh TL. Spinal botulinum neurotoxin B: effects on afferent transmitter release and nociceptive processing. PLoS One. 2011 Apr 29; 6(4):e19126. PMID: 21559464; PMCID: PMC3084763.
    83. Takasusuki T, Yaksh TL. The effects of intrathecal and systemic gabapentin on spinal substance P release. Anesth Analg. 2011 Apr; 112(4):971-6. PMID: 21385982; PMCID: PMC3347974.
    84. Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. J Neurosci. 2011 Feb 09; 31(6):2113-24. PMID: 21307248; PMCID: PMC3097059.
    85. Oshiro M, Hefferan MP, Kakinohana O, Lukacova N, Sugahara K, Yaksh TL, Marsala M. Suppression of stretch reflex activity after spinal or systemic treatment with AMPA receptor antagonist NGX424 in rats with developed baclofen tolerance. Br J Pharmacol. 2010 Nov; 161(5):976-85. PMID: 20977450; PMCID: PMC2998680.
    86. Christianson CA, Corr M, Firestein GS, Mobargha A, Yaksh TL, Svensson CI. Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis. Pain. 2010 Nov; 151(2):394-403. PMID: 20739123; PMCID: PMC2955775.
    87. Peters CM, Hayashida K, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res. 2010 Sep 17; 1352:83-93. PMID: 20637741; PMCID: PMC2943762.
    88. Matsui T, Svensson CI, Hirata Y, Mizobata K, Hua XY, Yaksh TL. Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase. Anesth Analg. 2010 Aug; 111(2):554-60. PMID: 20610553.
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    89. Westin BD, Walker SM, Deumens R, Grafe M, Yaksh TL. Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat. Anesthesiology. 2010 Jul; 113(1):183-99. PMID: 20526189; PMCID: PMC2902725.
    90. Walker SM, Westin BD, Deumens R, Grafe M, Yaksh TL. Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome. Anesthesiology. 2010 Jul; 113(1):147-59. PMID: 20526188; PMCID: PMC2904694.
    91. Watabiki T, Nagakura Y, Wegner K, Kakimoto S, Tozier NA, Malkmus SA, Yaksh TL. Assessment of canine sensory function by using sine-wave electrical stimuli paradigm. Physiol Behav. 2010 Oct 05; 101(3):327-30. PMID: 20570687.
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    92. Buczynski MW, Svensson CI, Dumlao DS, Fitzsimmons BL, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA. Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. J Neurochem. 2010 Aug; 114(4):981-93. PMID: 20492349; PMCID: PMC3994888.
    93. Eisenach JC, Curry R, Tong C, Houle TT, Yaksh TL. Effects of intrathecal ketorolac on human experimental pain. Anesthesiology. 2010 May; 112(5):1216-24. PMID: 20395821; PMCID: PMC2924167.
    94. Eisenach JC, Curry R, Rauck R, Pan P, Yaksh TL. Role of spinal cyclooxygenase in human postoperative and chronic pain. Anesthesiology. 2010 May; 112(5):1225-33. PMID: 20395820; PMCID: PMC2892621.
    95. Usvald D, Vodicka P, Hlucilova J, Prochazka R, Motlik J, Kuchorova K, Johe K, Marsala S, Scadeng M, Kakinohana O, Navarro R, Santa M, Hefferan MP, Yaksh TL, Marsala M. Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs. Cell Transplant. 2010; 19(9):1103-22. PMID: 20412634.
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    96. Yaksh TL, Eisenach JC, Shafer SL. Consent contraindicated? Science. 2010 Apr 02; 328(5974):45; author reply 45. PMID: 20360092.
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    97. Eisenach JC, Shafer SL, Yaksh T. The need for a journal policy on intrathecal, epidural, and perineural administration of non-approved drugs. Pain. 2010 Jun; 149(3):417-9. PMID: 20227830.
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    98. Fitzsimmons BL, Zattoni M, Svensson CI, Steinauer J, Hua XY, Yaksh TL. Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression. Neuroreport. 2010 Mar 10; 21(4):313-7. PMID: 20134354; PMCID: PMC2877130.
    99. Scholz J, Yaksh TL. Preclinical research on persistent postsurgical pain: what we don't know, but should start studying. Anesthesiology. 2010 Mar; 112(3):511-3. PMID: 20124975; PMCID: PMC2828501.
    100. Yaksh TL. [Vacuoles: a hollow threat?]. Can J Anaesth. 2010 Mar; 57(3):195-200. PMID: 20054677; PMCID: PMC2821579.
    101. McCann S, Yaksh TL, von Gunten CF. Correlation between myoclonus and the 3-glucuronide metabolites in patients treated with morphine or hydromorphone: a pilot study. J Opioid Manag. 2010 Mar-Apr; 6(2):87-94. PMID: 20481173.
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    102. Park P, Schachter S, Yaksh T. Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. Neurosci Lett. 2010 Feb 05; 470(1):6-9. PMID: 20026382; PMCID: PMC2834555.
    103. Sorkin LS, Yaksh TL. Behavioral models of pain states evoked by physical injury to the peripheral nerve. Neurotherapeutics. 2009 Oct; 6(4):609-19. PMID: 19789066.
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    104. Cohen SP, Bogduk N, Dragovich A, Buckenmaier CC, Griffith S, Kurihara C, Raymond J, Richter PJ, Williams N, Yaksh TL. Randomized, double-blind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica. Anesthesiology. 2009 May; 110(5):1116-26. PMID: 19387178.
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    105. Ilfeld BM, Yaksh TL. The end of postoperative pain--a fast-approaching possibility? And, if so, will we be ready? Reg Anesth Pain Med. 2009 Mar-Apr; 34(2):85-7. PMID: 19282704.
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    106. Bradesi S, Svensson CI, Steinauer J, Pothoulakis C, Yaksh TL, Mayer EA. Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology. 2009 Apr; 136(4):1339-48, e1-2. PMID: 19249394; PMCID: PMC2812027.
    107. Ray SB, Yaksh TL. Spinal antinociceptive action of loperamide is mediated by opioid receptors in the formalin test in rats. Neurosci Lett. 2008 Dec 31; 448(3):260-2. PMID: 18973791; PMCID: PMC2753543.
    108. Svensson CI, Medicherla S, Malkmus S, Jiang Y, Ma JY, Kerr I, Brainin-Mattos J, Powell HC, Luo ZD, Chakravarty S, Dugar S, Higgins LS, Protter AA, Yaksh TL. Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain. Pharmacol Biochem Behav. 2008 Oct; 90(4):664-75. PMID: 18584857.
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    109. Ilieva HS, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW. Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12599-604. PMID: 18719118; PMCID: PMC2527957.
    110. Nagakura Y, Jones TL, Malkmus SA, Sorkin L, Yaksh TL. The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy. Pain. 2008 Oct 31; 139(3):569-77. PMID: 18692315; PMCID: PMC3346272.
    111. Crawley B, Saito O, Malkmus S, Fitzsimmons B, Hua XY, Yaksh TL. Acetaminophen prevents hyperalgesia in central pain cascade. Neurosci Lett. 2008 Sep 05; 442(1):50-3. PMID: 18601979; PMCID: PMC2669887.
    112. Leung AY, Kim SJ, Schulteis G, Yaksh T. The effect of acupuncture duration on analgesia and peripheral sensory thresholds. BMC Complement Altern Med. 2008 May 01; 8:18. PMID: 18452622; PMCID: PMC2386116.
    113. Yaksh TL, Tozier N, Horais KA, Malkmus S, Rathbun M, Lafranco L, Eisenach J. Toxicology profile of N-methyl-D-aspartate antagonists delivered by intrathecal infusion in the canine model. Anesthesiology. 2008 May; 108(5):938-49. PMID: 18431131.
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    114. Khan IM, Wart CV, Singletary EA, Stanislaus S, Deerinck T, Yaksh TL, Printz MP. Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. Neuropharmacology. 2008 Feb; 54(2):269-79. PMID: 18037142; PMCID: PMC4418974.
    115. Hefferan MP, Kucharova K, Kinjo K, Kakinohana O, Sekerkova G, Nakamura S, Fuchigami T, Tomori Z, Yaksh TL, Kurtz N, Marsala M. Spinal astrocyte glutamate receptor 1 overexpression after ischemic insult facilitates behavioral signs of spasticity and rigidity. J Neurosci. 2007 Oct 17; 27(42):11179-91. PMID: 17942713.
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    116. Wegner K, Horais KA, Tozier NA, Rathbun ML, Shtaerman Y, Yaksh TL. Development of a canine nociceptive thermal escape model. J Neurosci Methods. 2008 Feb 15; 168(1):88-97. PMID: 18054083; PMCID: PMC2266689.
    117. Yaksh TL. Neonates have a spinal alpha receptor too, as do adults. Br J Pharmacol. 2007 Aug; 151(8):1139-40. PMID: 17641678; PMCID: PMC2189816.
    118. Ilfeld BM, Yaksh TL, Neal JM. Mandating two-year regional anesthesia fellowships: fanning the academic flame or extinguishing it? Reg Anesth Pain Med. 2007 Jul-Aug; 32(4):275-9. PMID: 17720109; PMCID: PMC2048748.
    119. Nagakura Y, Malkmus S, Yaksh TL. Determination of current threshold for paw withdrawal with sine-wave electrical stimulation in rats: effect of drugs and alteration in acute inflammation. Pain. 2008 Feb; 134(3):293-301. PMID: 17583428.
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    120. Kern SE, Allen J, Wagstaff J, Shafer SL, Yaksh T. The pharmacokinetics of the conopeptide contulakin-G (CGX-1160) after intrathecal administration: an analysis of data from studies in beagles. Anesth Analg. 2007 Jun; 104(6):1514-20, table of contents. PMID: 17513651.
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    121. Allen JW, Hofer K, McCumber D, Wagstaff JD, Layer RT, McCabe RT, Yaksh TL. An assessment of the antinociceptive efficacy of intrathecal and epidural contulakin-G in rats and dogs. Anesth Analg. 2007 Jun; 104(6):1505-13, table of contents. PMID: 17513650.
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    122. Tang Q, Svensson CI, Fitzsimmons B, Webb M, Yaksh TL, Hua XY. Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation. Eur J Neurosci. 2007 May; 25(10):2964-72. PMID: 17561811.
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    123. Svensson CI, Tran TK, Fitzsimmons B, Yaksh TL, Hua XY. Descending serotonergic facilitation of spinal ERK activation and pain behavior. FEBS Lett. 2006 Dec 11; 580(28-29):6629-34. PMID: 17113581; PMCID: PMC2291024.
    124. Leung AY, Park J, Schulteis G, Duann JR, Yaksh T. The electrophysiology of de qi sensations. J Altern Complement Med. 2006 Oct; 12(8):743-50. PMID: 17034280.
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    125. Allen JW, Horais KA, Tozier NA, Yaksh TL. Opiate pharmacology of intrathecal granulomas. Anesthesiology. 2006 Sep; 105(3):590-8. PMID: 16931994.
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    126. Allen JW, Horais KA, Tozier NA, Wegner K, Corbeil JA, Mattrey RF, Rossi SS, Yaksh TL. Time course and role of morphine dose and concentration in intrathecal granuloma formation in dogs: a combined magnetic resonance imaging and histopathology investigation. Anesthesiology. 2006 Sep; 105(3):581-9. PMID: 16931993.
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    127. Rossi S, Yaksh T, Bentley H, van den Brande G, Grant I, Ellis R. Characterization of interference with 6 commercial delta9-tetrahydrocannabinol immunoassays by efavirenz (glucuronide) in urine. Clin Chem. 2006 May; 52(5):896-7. PMID: 16638958.
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    128. Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin LS. Covariance among age, spinal p38 MAP kinase activation and allodynia. J Pain. 2006 May; 7(5):337-45. PMID: 16632323.
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    129. Brainin-Mattos J, Smith ND, Malkmus S, Rew Y, Goodman M, Taulane J, Yaksh TL. Cancer-related bone pain is attenuated by a systemically available delta-opioid receptor agonist. Pain. 2006 May; 122(1-2):174-81. PMID: 16545911.
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    130. Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL. Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs. Toxicol Sci. 2006 May; 91(1):286-98. PMID: 16500924.
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    131. Shi TJ, Hua XY, Lu X, Malkmus S, Kinney J, Holmberg K, Wirz S, Ceccatelli S, Yaksh T, Bartfai T, Hökfelt T. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur J Neurosci. 2006 Feb; 23(3):627-36. PMID: 16487144.
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    132. Yaksh TL. Calcium channels as therapeutic targets in neuropathic pain. J Pain. 2006 Jan; 7(1 Suppl 1):S13-30. PMID: 16426997.
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    133. Hua XY, Svensson CI, Matsui T, Fitzsimmons B, Yaksh TL, Webb M. Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia. Eur J Neurosci. 2005 Nov; 22(10):2431-40. PMID: 16307586.
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    134. Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. J Pharmacol Exp Ther. 2006 Jan; 316(1):466-75. PMID: 16203828.
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    135. Svensson CI, Hua XY, Powell HC, Lai J, Porreca F, Yaksh TL. Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. Neuropeptides. 2005 Oct; 39(5):485-94. PMID: 16176831.
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    136. Nielsen CK, Lewis RJ, Alewood D, Drinkwater R, Palant E, Patterson M, Yaksh TL, McCumber D, Smith MT. Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain. 2005 Nov; 118(1-2):112-24. PMID: 16154696.
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    137. Torchia M, Yaksh T. Unexpected pain in a dog: aberration or worthy of a citation? Agree to disagree. Lab Anim (NY). 2005 Sep; 34(8):19. PMID: 16136070.
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    138. Leung A, Khadivi B, Duann JR, Cho ZH, Yaksh T. The effect of Ting point (tendinomuscular meridians) electroacupuncture on thermal pain: a model for studying the neuronal mechanism of acupuncture analgesia. J Altern Complement Med. 2005 Aug; 11(4):653-61. PMID: 16131289.
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    139. Leung AY, Wallace MS, Schulteis G, Yaksh TL. Qualitative and quantitative characterization of the thermal grill. Pain. 2005 Jul; 116(1-2):26-32. PMID: 15935558.
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    140. Gu G, Kondo I, Hua XY, Yaksh TL. Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence. J Pharmacol Exp Ther. 2005 Sep; 314(3):1362-9. PMID: 15908510.
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    141. Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL. Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. J Neurosci. 2005 Apr 06; 25(14):3651-60. PMID: 15814796.
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    142. Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. Br J Pharmacol. 2005 Apr; 144(7):940-52. PMID: 15685208; PMCID: PMC1576074.
    143. Svensson CI, Fitzsimmons B, Azizi S, Powell HC, Hua XY, Yaksh TL. Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. J Neurochem. 2005 Mar; 92(6):1508-20. PMID: 15748168.
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    144. Marsala M, Kakinohana O, Yaksh TL, Tomori Z, Marsala S, Cizkova D. Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia. Eur J Neurosci. 2004 Nov; 20(9):2401-14. PMID: 15525281.
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    145. Khan IM, Wennerholm M, Singletary E, Polston K, Zhang L, Deerinck T, Yaksh TL, Taylor P. Ablation of primary afferent terminals reduces nicotinic receptor expression and the nociceptive responses to nicotinic agonists in the spinal cord. J Neurocytol. 2004 Sep; 33(5):543-56. PMID: 15906161.
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    146. Massie JB, Huang B, Malkmus S, Yaksh TL, Kim CW, Garfin SR, Akeson WH. A preclinical post laminectomy rat model mimics the human post laminectomy syndrome. J Neurosci Methods. 2004 Aug 30; 137(2):283-9. PMID: 15262072.
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    147. Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10470-5. PMID: 15240875; PMCID: PMC478593.
    148. Koetzner L, Gregory JA, Yaksh TL. Intrathecal protease-activated receptor stimulation produces thermal hyperalgesia through spinal cyclooxygenase activity. J Pharmacol Exp Ther. 2004 Oct; 311(1):356-63. PMID: 15175421.
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    149. Yaksh TL, Allen JW. The use of intrathecal midazolam in humans: a case study of process. Anesth Analg. 2004 Jun; 98(6):1536-45, table of contents. PMID: 15155302.
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    150. Yaksh TL, Allen JW. Preclinical insights into the implementation of intrathecal midazolam: a cautionary tale. Anesth Analg. 2004 Jun; 98(6):1509-11. PMID: 15155298.
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    151. Yaksh TL, Horais KA, Tozier N, Rathbun M, Richter P, Rossi S, Grafe M, Tong C, Meschter C, Cline JM, Eisenach J. Intrathecal ketorolac in dogs and rats. Toxicol Sci. 2004 Aug; 80(2):322-34. PMID: 15141096.
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    152. Ghilardi JR, Svensson CI, Rogers SD, Yaksh TL, Mantyh PW. Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia. J Neurosci. 2004 Mar 17; 24(11):2727-32. PMID: 15028765.
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    153. Koetzner L, Hua XY, Lai J, Porreca F, Yaksh T. Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. J Neurosci. 2004 Feb 11; 24(6):1451-8. PMID: 14960618.
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    154. Eisenach JC, Hood DD, Curry R, Sawynok J, Yaksh TL, Li X. Intrathecal but not intravenous opioids release adenosine from the spinal cord. J Pain. 2004 Feb; 5(1):64-8. PMID: 14975380.
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    155. Schäfers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C. Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Exp Neurol. 2004 Jan; 185(1):160-8. PMID: 14697327.
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    156. Malkmus SA, Yaksh TL. Intrathecal catheterization and drug delivery in the rat. Methods Mol Med. 2004; 99:109-21. PMID: 15131333.
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    157. Allen JW, Yaksh TL. Tissue injury models of persistent nociception in rats. Methods Mol Med. 2004; 99:25-34. PMID: 15131326.
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    158. Allen JW, Yaksh TL. Assessment of acute thermal nociception in laboratory animals. Methods Mol Med. 2004; 99:11-23. PMID: 15131325.
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    159. Khan I, Osaka H, Stanislaus S, Calvo RM, Deerinck T, Yaksh TL, Taylor P. Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways. J Comp Neurol. 2003 Dec 01; 467(1):44-59. PMID: 14574679.
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    160. Hua XY, Hayes CS, Hofer A, Fitzsimmons B, Kilk K, Langel U, Bartfai T, Yaksh TL. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther. 2004 Feb; 308(2):574-82. PMID: 14610237.
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    161. Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003 Sep; 86(6):1534-44. PMID: 12950462.
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    162. Yaksh TL, Horais KA, Tozier NA, Allen JW, Rathbun M, Rossi SS, Sommer C, Meschter C, Richter PJ, Hildebrand KR. Chronically infused intrathecal morphine in dogs. Anesthesiology. 2003 Jul; 99(1):174-87. PMID: 12826858.
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    163. Yaksh TL. Preclinical work leading to the development of spinal analgesia. Anesthesiology. 2003 Jul; 99(1):224-5. PMID: 12826864.
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    164. Hayes CS, Mulkmus SA, Cizkova D, Yaksh TL, Hua XY. A double-lumen intrathecal catheter for studies of modulation of spinal opiate tolerance. J Neurosci Methods. 2003 Jun 30; 126(2):165-73. PMID: 12814841.
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    165. South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage FH, Yaksh TL, Woolf CJ, Heinemann SF, Inturrisi CE. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosci. 2003 Jun 15; 23(12):5031-40. PMID: 12832526.
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    166. Svensson CI, Hua XY, Protter AA, Powell HC, Yaksh TL. Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia. Neuroreport. 2003 Jun 11; 14(8):1153-7. PMID: 12821799.
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    167. Kakinohana M, Marsala M, Carter C, Davison JK, Yaksh TL. Neuraxial morphine may trigger transient motor dysfunction after a noninjurious interval of spinal cord ischemia: a clinical and experimental study. Anesthesiology. 2003 Apr; 98(4):862-70. PMID: 12657847.
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    168. Schäfers M, Lee DH, Brors D, Yaksh TL, Sorkin LS. Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci. 2003 Apr 01; 23(7):3028-38. PMID: 12684490.
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    169. Rossi S, Yaksh T. Rapid quantification of the non-competitive NMDA antagonist MK-801 in canine cerebrospinal fluid and plasma by capillary gas chromatography-nitrogen phosphorus detection. J Pharm Biomed Anal. 2003 Feb 26; 31(2):243-50. PMID: 12609663.
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    170. Horais K, Hruby V, Rossi S, Cizkova D, Meschter C, Dorr R, Yaksh TL. Effects of chronic intrathecal infusion of a partial differential opioid agonist in dogs. Toxicol Sci. 2003 Feb; 71(2):263-75. PMID: 12563112.
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    171. Ibuki T, Marsala M, Masuyama T, Yaksh TL. Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats. Br J Pharmacol. 2003 Feb; 138(4):689-97. PMID: 12598423; PMCID: PMC1573708.
    172. Svensson CI, Rew Y, Malkmus S, Schiller PW, Taulane JP, Goodman M, Yaksh TL. Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog. J Pharmacol Exp Ther. 2003 Feb; 304(2):827-32. PMID: 12538839.
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    173. Eisenach JC, Yaksh TL. Epidural ketamine in healthy children--what's the point? Anesth Analg. 2003 Feb; 96(2):626; author reply 626-7. PMID: 12538224.
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    174. Yaksh TL, Hassenbusch S, Burchiel K, Hildebrand KR, Page LM, Coffey RJ. Inflammatory masses associated with intrathecal drug infusion: a review of preclinical evidence and human data. Pain Med. 2002 Dec; 3(4):300-12. PMID: 15099235.
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    175. Eisenach JC, Yaksh TL. Safety in numbers: how do we study toxicity of spinal analgesics? Anesthesiology. 2002 Nov; 97(5):1047-9. PMID: 12411784.
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    176. Khan IM, Singletary E, Alemayehu A, Stanislaus S, Printz MP, Yaksh TL, Taylor P. Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness. Physiol Genomics. 2002 Oct 29; 11(2):65-72. PMID: 12388796.
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    177. Eisenach JC, Curry R, Hood DD, Yaksh TL. Phase I safety assessment of intrathecal ketorolac. Pain. 2002 Oct; 99(3):599-604. PMID: 12406536.
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    178. Luger NM, Sabino MA, Schwei MJ, Mach DB, Pomonis JD, Keyser CP, Rathbun M, Clohisy DR, Honore P, Yaksh TL, Mantyh PW. Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain. Pain. 2002 Oct; 99(3):397-406. PMID: 12406514.
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    179. Cizkova D, Marsala J, Lukacova N, Marsala M, Jergova S, Orendacova J, Yaksh TL. Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury. Exp Brain Res. 2002 Dec; 147(4):456-63. PMID: 12444477.
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    180. Rew Y, Malkmus S, Svensson C, Yaksh TL, Chung NN, Schiller PW, Cassel JA, DeHaven RN, Taulane JP, Goodman M. Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands. J Med Chem. 2002 Aug 15; 45(17):3746-54. PMID: 12166947.
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    181. Rossi S, Yaksh T. Rapid quantification of the delta-opioid receptor selective enkephalin DPDPE in canine cerebrospinal fluid by liquid chromatography--mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 25; 772(1):73-9. PMID: 12016017.
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    182. Nozaki-Taguchi N, Yaksh TL. Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury. Anesth Analg. 2002 Apr; 94(4):968-74, table of contents. PMID: 11916806.
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    183. Nozaki-Taguchi N, Yaksh TL. Pharmacology of spinal glutamatergic receptors in post-thermal injury-evoked tactile allodynia and thermal hyperalgesia. Anesthesiology. 2002 Mar; 96(3):617-26. PMID: 11873037.
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    184. Schäfers M, Geis C, Brors D, Yaksh TL, Sommer C. Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve. J Neurosci. 2002 Jan 15; 22(2):536-45. PMID: 11784800.
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    185. Svensson CI, Yaksh TL. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annu Rev Pharmacol Toxicol. 2002; 42:553-83. PMID: 11807183.
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    186. Wallace MS, Ridgeway B, Leung A, Schulteis G, Yaksh TL. Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia. J Clin Pharmacol. 2002 Jan; 42(1):70-80. PMID: 11808827.
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    187. Yaksh TL, Scott B, LeBel CL. Effects of continuous lumbar intrathecal infusion of leptin in rats on weight regulation. Neuroscience. 2002; 110(4):703-10. PMID: 11934477.
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    188. Yaksh TL. Future advances in pain pharmacology: what does the present say about the future? Proc West Pharmacol Soc. 2002; 45:211-8. PMID: 12434582.
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    189. Yaksh TL, Dirig DM, Conway CM, Svensson C, Luo ZD, Isakson PC. The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. J Neurosci. 2001 Aug 15; 21(16):5847-53. PMID: 11487607.
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    190. Yaksh TL, Ozaki G, McCumber D, Rathbun M, Svensson C, Malkmus S, Yaksh MC. An automated flinch detecting system for use in the formalin nociceptive bioassay. J Appl Physiol (1985). 2001 Jun; 90(6):2386-402. PMID: 11356806.
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    191. Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, Marsala M. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):7680-6. PMID: 10393880; PMCID: PMC33601.
    192. Yaksh TL, Provencher JC, Rathbun ML, Kohn FR. Pharmacokinetics and efficacy of epidurally delivered sustained-release encapsulated morphine in dogs. Anesthesiology. 1999 May; 90(5):1402-12. PMID: 10319789.
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    193. Yaksh TL, Dirig DM, Malmberg AB. Mechanism of action of nonsteroidal anti-inflammatory drugs. Cancer Invest. 1998; 16(7):509-27. PMID: 9774958.
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