Tony Yaksh

Title(s)Recall Faculty, Anesthesiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    B.S.Georgia Institute of Technology
    M.S.University of Georgia
    Ph.D.Purdue University
    Collapse Awards and Honors
    1995American Society of Anesthesiology (ASA) Award for Excellence in Research;
    1996Emmanuel Papper Lecturer, Columbia Presbyterian Hospital
    1998Joris De Castro Memorial Lecture - Belgian Society of Anaesthesia and Reanimation
    1998American Academy of Pain Medicine, Award for Outstanding Contributions to Pain Medicine
    1999UCSD Chancellor’s Associates Faculty Excellence Award in Research
    1999American Academy of Pain Management, The John Liebeskind Award for Pain Research
    2000Swedish Society of Medicine, Torsten Gordh lecturer
    2001New York Society of Anesthesiologists Rovenstine Lecturer
    2007Javitz Award in Neuroscience; National Institute of Neurological, Communicative Diseases and Stroke
    2007Schueler Distinguished Lecturer award, Tulane University
    2007Seldon Memorial Lecturer award, International Anesthesia Research Society
    2007German Promotion Award for Pain Research and Therapy, German Pain Association
    2008ohn J. Bonica Distinguished Lecturer, International Association for the Study of Pain
    2012Presidential Commendation, World Institute of Pain
    2015Lifetime achievement award (North American Neuromodulation Society - NANS)
    2017Spain Distinguished Service Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Pre-clinical evaluation of DT-001, a small molecule antagonist of MD2-TLR4 for utility in the treatment of pain.
    NIH R41NS113717Sep 30, 2019 - Aug 31, 2021
    Role: Principal Investigator
    New Approach to Atopic Dermatitis
    NIH R43AR072546Sep 1, 2018 - Aug 31, 2021
    Role: Co-Principal Investigator
    Reversal of preexisting neuropathic pain by spinal delivery of AIBP
    NIH R33NS104769Aug 1, 2018 - Jul 31, 2021
    Role: Co-Principal Investigator
    Reversal of preexisting neuropathic pain by spinal delivery of AIBP
    NIH R21NS104769Aug 1, 2018 - Jul 31, 2020
    Role: Co-Principal Investigator
    AIBP and regulation of neuropathic pain
    NIH R01NS102432Aug 15, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Sex, Stress and Immunity in the Acute to Chronic Pain Transition
    NIH R01NS099338Dec 15, 2016 - Nov 30, 2021
    Role: Principal Investigator
    Construction and Analysis of BoNT derivatives as Pain Specific Inhibitors
    NIH R21AI113580Aug 7, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Discovery of novel small molecule analgesics
    NIH R41NS086244May 15, 2014 - Dec 31, 2015
    Role: Principal Investigator
    Myelin Autoantigens in Neuropathic Pain
    NIH R01DE022757Jul 30, 2012 - Aug 31, 2023
    Role: Principal Investigator
    The role of selective brain penetrating GRPR antagonists in pruritis.
    NIH R21NS077348Sep 30, 2011 - Dec 30, 2013
    Role: Principal Investigator
    Pain Mechanisms and the Development of Analgesics
    NIH R13DA021484Mar 1, 2006 - Feb 28, 2007
    Role: Principal Investigator
    Characterization of Toxicity with Spinal Opiates
    NIH R01DA015353Jul 1, 2002 - Jun 30, 2020
    Role: Principal Investigator
    Spinal Galanin and its Receptors in Pain Processing
    NIH R01NS041954Jun 1, 2002 - May 31, 2006
    Role: Principal Investigator
    Neurobiology of Pain
    NIH T32NS007407Jul 1, 1997 - Jun 30, 2007
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Jul 1, 1996 - Apr 30, 2024
    Role: Co-Investigator
    PRECLINICAL TOXICOLOGY STUDIES OF NMDA ANTAGONISTS
    NIH R01NS033846Aug 1, 1994 - Jul 31, 1998
    Role: Principal Investigator
    NEW MODALITIES FOR TREATMENT OF PAIN AND DRUG ABUSE
    NIH P01DA006284Sep 30, 1989 - Mar 31, 2016
    Role: Co-Investigator
    Pain Evoked Release of Amino Acids and Prostanoids
    NIH R37NS016541Sep 1, 1988 - Feb 28, 2013
    Role: Principal Investigator
    PEPTIDE RELEASE FROM PERIPHERAL TERMINALS OF AFFERENTS
    NIH R01AI026249Apr 1, 1988 - Mar 31, 1992
    Role: Principal Investigator
    The Pharmacology of Spinal Analgesics
    NIH R01DA002110Jul 1, 1983 - Jan 31, 2016
    Role: Principal Investigator
    SPINAL PHARMACOLOGY OF BLADDER FUNCTION
    NIH R01NS019650Jul 1, 1983 - Jun 30, 1986
    Role: Principal Investigator
    PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    NIH R01NS016541Jul 1, 1980 - Dec 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sex differences in neuroimmune and glial mechanisms of pain. Pain. 2021 Aug 01; 162(8):2186-2200. Gregus AM, Levine IS, Eddinger KA, Yaksh TL, Buczynski MW. PMID: 34256379.
      View in: PubMed   Mentions:    Fields:    
    2. Treating osteoarthritis pain: mechanisms of action of acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, and nerve growth factor antibodies. Postgrad Med. 2021 Jul 12; 1-16. D'Arcy Y, Mantyh P, Yaksh T, Donevan S, Hall J, Sadrarhami M, Viktrup L. PMID: 34252357.
      View in: PubMed   Mentions:    Fields:    
    3. Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain. J Exp Med. 2021 Jul 05; 218(7). Navia-Pelaez JM, Choi SH, Dos Santos Aggum Capettini L, Xia Y, Gonen A, Agatisa-Boyle C, Delay L, Gonçalves Dos Santos G, Catroli GF, Kim J, Lu JW, Saylor B, Winkels H, Durant CP, Ghosheh Y, Beaton G, Ley K, Kufareva I, Corr M, Yaksh TL, Miller YI. PMID: 33970188.
      View in: PubMed   Mentions:    Fields:    
    4. Long-lasting analgesia via targeted in situ repression of NaV1.7 in mice. Sci Transl Med. 2021 03 10; 13(584). Moreno AM, Alemán F, Catroli GF, Hunt M, Hu M, Dailamy A, Pla A, Woller SA, Palmer N, Parekh U, McDonald D, Roberts AJ, Goodwill V, Dryden I, Hevner RF, Delay L, Gonçalves Dos Santos G, Yaksh TL, Mali P. PMID: 33692134.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    5. Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis. Rheum Dis Clin North Am. 2021 May; 47(2):245-264. Delay L, Gonçalves Dos Santos G, Dias EV, Yaksh TL, Corr M. PMID: 33781493.
      View in: PubMed   Mentions:    Fields:    
    6. Lipid rafts in glial cells: role in neuroinflammation and pain processing: Thematic Review Series: Biology of Lipid Rafts. J Lipid Res. 2020 05; 61(5):655-666. Miller YI, Navia-Pelaez JM, Corr M, Yaksh TL. PMID: 33715813.
      View in: PubMed   Mentions:    Fields:    
    7. Unintended consequences of COVID-19 safety measures on patients with chronic knee pain forced to defer joint replacement surgery. Pain Rep. 2020 Nov-Dec; 5(6):e855. Cisternas AF, Ramachandran R, Yaksh TL, Nahama A. PMID: 33134751.
      View in: PubMed   Mentions:
    8. The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling. Sci Rep. 2020 09 24; 10(1):15596. Gonçalves Dos Santos G, Jimenéz-Andrade JM, Woller SA, Muñoz-Islas E, Ramírez-Rosas MB, Ohashi N, Ferreira Catroli G, Fujita Y, Yaksh TL, Corr M. PMID: 32973194.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    9. Topical Application of ASN008, a Permanently Charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset, and Long Duration of Action in a Mouse Model of Pruritus. J Pharmacol Exp Ther. 2020 09; 374(3):521-528. Ramachandran R, Thompson SK, Malkmus S, Mieda T, Lin JH, Gupta S, Yaksh TL. PMID: 32616515.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice. J Biol Chem. 2020 07 31; 295(31):10807-10821. Chernov AV, Hullugundi SK, Eddinger KA, Dolkas J, Remacle AG, Angert M, James BP, Yaksh TL, Strongin AY, Shubayev VI. PMID: 32532796.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Pharmacodynamics of intrathecal and epidural fadolmidine, an a2-adrenoceptor agonist, after bolus and infusion in dogs-comparison with clonidine. Naunyn Schmiedebergs Arch Pharmacol. 2020 08; 393(8):1459-1473. Leino T, Yaksh T, Horais K, Haapalinna A. PMID: 32179953.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. Neuraxial Cytokines in Pain States. Front Immunol. 2019; 10:3061. Gonçalves Dos Santos G, Delay L, Yaksh TL, Corr M. PMID: 32047493.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    13. Lipid rafts in glial cells: role in neuroinflammation and pain processing. J Lipid Res. 2020 05; 61(5):655-666. Miller YI, Navia-Pelaez JM, Corr M, Yaksh TL. PMID: 31862695.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety. Pain. 2019 10; 160(10):2210-2220. Schmelz M, Mantyh P, Malfait AM, Farrar J, Yaksh T, Tive L, Viktrup L. PMID: 31145219.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    15. Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling. Anesthesiology. 2019 07; 131(1):132-147. Yaksh TL, Eddinger KA, Kokubu S, Wang Z, DiNardo A, Ramachandran R, Zhu Y, He Y, Weren F, Quang D, Malkmus SA, Lansu K, Kroeze WK, Eliceiri B, Steinauer JJ, Schiller PW, Gmeiner P, Page LM, Hildebrand KR. PMID: 31225809.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Characterization of Effect of Repeated Bolus or Continuous Intrathecal Infusion of Morphine on Spinal Mass Formation in the Dog. Neuromodulation. 2019 Oct; 22(7):790-798. Hildebrand KR, Page LM, Billstrom TM, Steinauer JJ, Eddinger KA, Arjomand S, Yaksh TL. PMID: 31124198.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Unilateral Epidural Targeting of Resiniferatoxin Induces Bilateral Neurolysis of Spinal Nociceptive Afferents. Pain Med. 2019 05 01; 20(5):897-906. Unger MD, Pleticha J, Steinauer J, Kanwar R, Diehn F, LaVallee KT, Banck MS, Jones B, Yaksh TL, Maus TP, Beutler AS. PMID: 30590777.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    18. Characterization of Analgesic Actions of the Chronic Intrathecal Infusion of H-Dmt-D-Arg-Phe-Lys-NH2 in Rat. Neuromodulation. 2019 Oct; 22(7):781-789. Kokubu S, Eddinger KA, Yamaguchi S, Huerta-Esquivel LL, Schiller PW, Yaksh TL. PMID: 30794333.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    19. Letter to Editor re: "Unique Intradural Inflammatory Mass Containing Precipitated Morphine" by Kim et al. Pain Pract. 2019 04; 19(4):456. Yaksh TL. PMID: 30614650.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery. Scand J Pain. 2019 01 28; 19(1):193-206. Kokubu S, Eddinger KA, Nguyen TM, Huerta-Esquivel LL, Yamaguchi S, Schiller PW, Yaksh TL. PMID: 30367811.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    21. Role of Toll-like receptor 4 signaling in mast cell-mediated migraine pain pathway. Mol Pain. 2019 Jan-Dec; 15:1744806919867842. Ramachandran R, Wang Z, Saavedra C, DiNardo A, Corr M, Powell SB, Yaksh TL. PMID: 31342858.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. Botulinum toxin blocks mast cells and prevents rosacea like inflammation. J Dermatol Sci. 2019 Jan; 93(1):58-64. Choi JE, Werbel T, Wang Z, Wu CC, Yaksh TL, Di Nardo A. PMID: 30658871.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    23. Spinal Exparel®-an extended duration of preclinical study needed. Br J Anaesth. 2019 03; 122(3):298-300. Eisenach JC, Yaksh TL. PMID: 30770045.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    24. Development of New Analgesics: An Answer to Opioid Epidemic. Trends Pharmacol Sci. 2018 12; 39(12):1000-1002. Yaksh TL, Hunt MA, Dos Santos GG. PMID: 30454767.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    25. Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats. Pain. 2018 Dec; 159(12):2620-2629. Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. PMID: 30130298.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Neuraxial TNF and IFN-beta co-modulate persistent allodynia in arthritic mice. Brain Behav Immun. 2019 02; 76:151-158. Woller SA, Ocheltree C, Wong SY, Bui A, Fujita Y, Gonçalves Dos Santos G, Yaksh TL, Corr M. PMID: 30465880.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    27. Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome. Mol Pain. 2018 Jan-Dec; 14:1744806918815005. Shubayev VI, Strongin AY, Yaksh TL. PMID: 30392459.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    28. Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states. Pain. 2018 Oct; 159(10):1908-1915. Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K. PMID: 29889119.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    29. Transition to chronic pain: opportunities for novel therapeutics. Nat Rev Neurosci. 2018 07; 19(7):383-384. Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH. PMID: 29765159.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    30. Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States. Cell Rep. 2018 05 29; 23(9):2667-2677. Woller SA, Choi SH, An EJ, Low H, Schneider DA, Ramachandran R, Kim J, Bae YS, Sviridov D, Corr M, Yaksh TL, Miller YI. PMID: 29847797.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    31. Complexity of systems and actions underlying neurogenic inflammation. Semin Immunopathol. 2018 05; 40(3):225-228. Yaksh TL, Di Nardo A. PMID: 29779134.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    32. Rapid continuous 3D printing of customizable peripheral nerve guidance conduits. Mater Today (Kidlington). 2018 Nov; 21(9):951-959. Zhu W, Tringale KR, Woller SA, You S, Johnson S, Shen H, Schimelman J, Whitney M, Steinauer J, Xu W, Yaksh TL, Nguyen QT, Chen S. PMID: 31156331.
      View in: PubMed   Mentions:
    33. A Study and Review of Effects of Botulinum Toxins on Mast Cell Dependent and Independent Pruritus. Toxins (Basel). 2018 03 23; 10(4). Ramachandran R, Marino MJ, Paul S, Wang Z, Mascarenhas NL, Pellett S, Johnson EA, DiNardo A, Yaksh TL. PMID: 29570628.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    34. Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation. Semin Immunopathol. 2018 May; 40(3):237-247. Sorkin LS, Eddinger KA, Woller SA, Yaksh TL. PMID: 29423889.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    35. An overview of pathways encoding nociception. Clin Exp Rheumatol. 2018 Jan-Feb; 36(1):172. Woller SA, Eddinger KA, Corr M, Yaksh TL. PMID: 29461960.
      View in: PubMed   Mentions: 8     Fields:    
    36. Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular. Int J Toxicol. 2018 Jan/Feb; 37(1):4-27. Emami A, Tepper J, Short B, Yaksh TL, Bendele AM, Ramani T, Cisternas AF, Chang JH, Mellon RD. PMID: 29264927.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    37. Target engagement and histopathology of neuraxial resiniferatoxin in dog. Vet Anaesth Analg. 2018 Mar; 45(2):212-226. Hockman TM, Cisternas AF, Jones B, Butt MT, Osborn KG, Steinauer JJ, Malkmus SA, Yaksh TL. PMID: 29361418.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    38. Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics. Anesth Analg. 2017 11; 125(5):1714-1732. Knezevic NN, Yekkirala A, Yaksh TL. PMID: 29049116.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    39. Effects of opioid and nonopioid analgesics on canine wheal formation and cultured human mast cell degranulation. Toxicol Appl Pharmacol. 2018 01 01; 338:54-64. Schmidt-Rondon E, Wang Z, Malkmus SA, Di Nardo A, Hildebrand K, Page L, Yaksh TL. PMID: 29111148.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    40. An overview of pathways encoding nociception. Clin Exp Rheumatol. 2017 Sep-Oct; 35 Suppl 107(5):40-46. Woller SA, Eddinger KA, Corr M, Yaksh TL. PMID: 28967373.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    41. Editor's Highlight: Formulation and Toxicology Evaluation of the Intrathecal AYX1 DNA-Decoy in Sprague Dawley Rats. Toxicol Sci. 2017 09 01; 159(1):76-85. Mamet J, Yeomans DC, Yaksh TL, Manning DC, Harris S. PMID: 28903493.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    42. Modeling Spinal Intrathecal Drug Distribution: The Challenge of Defining and Predicting Cerebrospinal Fluid Dynamics. Anesth Analg. 2017 05; 124(5):1403-1406. Bert RJ, Hayek SM, Yaksh TL. PMID: 28426585.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 10; 18(10):1184-1196. Yaksh TL, Schwarcz R, Snodgrass HR. PMID: 28428091.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    44. Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model. Scand J Pain. 2017 07; 16:1-9. Rijsdijk M, Agalave NM, van Wijck AJM, Kalkman CJ, Ramachandran R, Baharpoor A, Svensson CI, Yaksh TL. PMID: 28850381.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    45. The Polyanalgesic Consensus Conference (PACC): Recommendations for Intrathecal Drug Delivery: Guidance for Improving Safety and Mitigating Risks. Neuromodulation. 2017 Feb; 20(2):155-176. Deer TR, Pope JE, Hayek SM, Lamer TJ, Veizi IE, Erdek M, Wallace MS, Grider JS, Levy RM, Prager J, Rosen SM, Saulino M, Yaksh TL, De Andrés JA, Abejon Gonzalez D, Vesper J, Schu S, Simpson B, Mekhail N. PMID: 28042914.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    46. The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines. Neuromodulation. 2017 02; 20(2):96-132. Deer TR, Pope JE, Hayek SM, Bux A, Buchser E, Eldabe S, De Andrés JA, Erdek M, Patin D, Grider JS, Doleys DM, Jacobs MS, Yaksh TL, Poree L, Wallace MS, Prager J, Rauck R, DeLeon O, Diwan S, Falowski SM, Gazelka HM, Kim P, Leong M, Levy RM, McDowell G, McRoberts P, Naidu R, Narouze S, Perruchoud C, Rosen SM, Rosenberg WS, Saulino M, Staats P, Stearns LJ, Willis D, Krames E, Huntoon M, Mekhail N. PMID: 28042904.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    47. Pharmacology, pharmacokinetics, and metabolism of the DNA-decoy AYX1 for the prevention of acute and chronic post-surgical pain. Mol Pain. 2017 01; 13:1744806917703112. Mamet J, Harris S, Klukinov M, Yeomans DC, Donahue RR, Taylor BK, Eddinger K, Yaksh T, Manning DC. PMID: 28394696.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    48. Current and Future Issues in the Development of Spinal Agents for the Management of Pain. Curr Neuropharmacol. 2017; 15(2):232-259. Yaksh TL, Fisher CJ, Hockman TM, Wiese AJ. PMID: 26861470.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    49. Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain. Brain Behav Immun. 2017 Feb; 60:282-292. Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi SK, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev VI. PMID: 27833045.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    50. Ethical Concerns Regarding Human Study. CNS Neurosci Ther. 2016 10; 22(10):866. Eisenach JC, Yaksh TL. PMID: 27577599.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    51. Primary Hydromorphone-Related Intrathecal Catheter Tip Granulomas: Is There a Role for Dose and Concentration? Neuromodulation. 2016 Oct; 19(7):760-769. Veizi IE, Hayek SM, Hanes M, Galica R, Katta S, Yaksh T. PMID: 27505059.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    52. Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation. Anesthesiology. 2016 08; 125(2):378-94. Eddinger KA, Rondon ES, Shubayev VI, Grafe MR, Scadeng M, Hildebrand KR, Page LM, Malkmus SA, Steinauer JJ, Yaksh TL. PMID: 27272672.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    53. Role of myelin auto-antigens in pain: a female connection. Neural Regen Res. 2016 Jun; 11(6):890-1. Shubayev VI, Strongin AY, Yaksh TL. PMID: 27482203.
      View in: PubMed   Mentions:
    54. Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt. Eur J Neurosci. 2016 07; 44(1):1714-22. Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R. PMID: 27108664.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    55. Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state. Brain Behav Immun. 2016 08; 56:271-80. Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Isseroff RR, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL. PMID: 27044335.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    56. Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid. Cannabis Cannabinoid Res. 2016; 1(1):102-112. Merrick J, Lane B, Sebree T, Yaksh T, O'Neill C, Banks SL. PMID: 28861485.
      View in: PubMed   Mentions:
    57. Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia. Brain Behav Immun. 2016 Aug; 56:378-89. Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev VI. PMID: 26970355.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    58. The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annu Rev Pharmacol Toxicol. 2016; 56:511-33. Podvin S, Yaksh T, Hook V. PMID: 26738478.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    59. Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models. Scand J Pain. 2016 01; 10:90-102. Rijsdijk M, Svensson CI, Wijck AJ, Kalkman CJ, Yaksh TL. PMID: 28361779.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    60. Current status and future directions of botulinum neurotoxins for targeting pain processing. Toxins (Basel). 2015 Nov 04; 7(11):4519-63. Pellett S, Yaksh TL, Ramachandran R. PMID: 26556371.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    61. The effects of intraplantar and intrathecal botulinum toxin type B on tactile allodynia in mono and polyneuropathy in the mouse. Anesth Analg. 2015 Jul; 121(1):229-38. Park HJ, Marino MJ, Rondon ES, Xu Q, Yaksh TL. PMID: 26039418.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    62. The search for novel analgesics: targets and mechanisms. F1000Prime Rep. 2015; 7:56. Yaksh TL, Woller SA, Ramachandran R, Sorkin LS. PMID: 26097729.
      View in: PubMed   Mentions:
    63. Botulinum toxin in migraine: Role of transport in trigemino-somatic and trigemino-vascular afferents. Neurobiol Dis. 2015 Jul; 79:111-22. Ramachandran R, Lam C, Yaksh TL. PMID: 25958249.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    64. Therapeutic use of botulinum toxin in migraine: mechanisms of action. Br J Pharmacol. 2014 Sep; 171(18):4177-92. Ramachandran R, Yaksh TL. PMID: 24819339.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    65. The effects of glucocorticoids on neuropathic pain: a review with emphasis on intrathecal methylprednisolone acetate delivery. Anesth Analg. 2014 May; 118(5):1097-112. Rijsdijk M, van Wijck AJ, Kalkman CJ, Yaksh TL. PMID: 24781577.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    66. TRPV1 expression regulation… A further step in defining its biology: commentary for K. Zavala et al. "The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons" [Neurosci. Lett. (2014) doi:10.1016/j.neulet.2014.01.021]. Neurosci Lett. 2014 Aug 22; 578:209-10. Yaksh TL. PMID: 24769421.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    67. Preclinical toxicity screening of intrathecal oxytocin in rats and dogs. Anesthesiology. 2014 Apr; 120(4):951-61. Yaksh TL, Hobo S, Peters C, Osborn KG, Richter PJ, Rossi SS, Grafe MR, Eisenach JC. PMID: 24492326.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    68. Supraspinal characterization of the thermal grill illusion with fMRI. Mol Pain. 2014 Mar 11; 10:18. Leung A, Shukla S, Li E, Duann JR, Yaksh T. PMID: 24612493.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    69. Botulinum toxin B in the sensory afferent: transmitter release, spinal activation, and pain behavior. Pain. 2014 Apr; 155(4):674-684. Marino MJ, Terashima T, Steinauer JJ, Eddinger KA, Yaksh TL, Xu Q. PMID: 24333775.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    70. Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. J Neuroinflammation. 2013 Dec 09; 10:148. Stokes JA, Cheung J, Eddinger K, Corr M, Yaksh TL. PMID: 24321498.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    71. Intrathecal substance P-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation. Anesthesiology. 2013 Nov; 119(5):1163-77. Wiese AJ, Rathbun M, Butt MT, Malkmus SA, Richter PJ, Osborn KG, Xu Q, Veesart SL, Steinauer JJ, Higgins D, Lappi DA, Russell B, Yaksh TL. PMID: 24051388.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    72. Toll-like receptor signaling regulates cisplatin-induced mechanical allodynia in mice. Cancer Chemother Pharmacol. 2014 Jan; 73(1):25-34. Park HJ, Stokes JA, Corr M, Yaksh TL. PMID: 24162377.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    73. Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury. Pain. 2014 Feb; 155(2):322-333. Mamet J, Klukinov M, Yaksh TL, Malkmus SA, Williams S, Harris S, Manning DC, Taylor BK, Donahue RR, Porreca F, Xie JY, Oyarzo J, Brennan TJ, Subieta A, Schmidt WK, Yeomans DC. PMID: 24145208.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    74. Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. J Pharmacol Exp Ther. 2013 Nov; 347(2):258-64. Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q. PMID: 23978562.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    75. Neuroscience: Bacteria get on your nerves. Nature. 2013 Sep 05; 501(7465):43-4. Nizet V, Yaksh T. PMID: 23965630.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    76. Effects of general anesthetics on substance P release and c-Fos expression in the spinal dorsal horn. Anesthesiology. 2013 Aug; 119(2):433-42. Takasusuki T, Yamaguchi S, Hamaguchi S, Yaksh TL. PMID: 23708866.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    77. Evaluation of spinal toxicity and long-term spinal reflex function after intrathecal levobupivaciane in the neonatal rat. Anesthesiology. 2013 Jul; 119(1):142-55. Hamurtekin E, Fitzsimmons BL, Shubayev VI, Grafe MR, Deumens R, Yaksh TL, Walker SM. PMID: 23514721.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    78. Intrathecal P/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression. Neuropharmacology. 2013 Dec; 75:1-8. Terashima T, Xu Q, Yamaguchi S, Yaksh TL. PMID: 23810829.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    79. Intrathecal neurosteroids and a neurosteroid antagonist: effects on inflammation-evoked thermal hyperalgesia and tactile allodynia. Neurosci Lett. 2013 Aug 26; 548:27-32. Svensson E, Persson J, Fitzsimmons B, Yaksh TL. PMID: 23707652.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    80. Role of meningeal mast cells in intrathecal morphine-evoked granuloma formation. Anesthesiology. 2013 Mar; 118(3):664-78. Yaksh TL, Allen JW, Veesart SL, Horais KA, Malkmus SA, Scadeng M, Steinauer JJ, Rossi SS. PMID: 23426209.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    81. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. FASEB J. 2013 May; 27(5):1939-49. Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA. PMID: 23382512.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    82. Spinal toll-like receptor signaling and nociceptive processing: regulatory balance between TIRAP and TRIF cascades mediated by TNF and IFNß. Pain. 2013 May; 154(5):733-742. Stokes JA, Corr M, Yaksh TL. PMID: 23489833.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    83. Spinal astrocytes produce and secrete dynorphin neuropeptides. Neuropeptides. 2013 Apr; 47(2):109-15. Wahlert A, Funkelstein L, Fitzsimmons B, Yaksh T, Hook V. PMID: 23290538.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    84. Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. Anesth Analg. 2013 Jan; 116(1):224-31. Park HJ, Stokes JA, Pirie E, Skahen J, Shtaerman Y, Yaksh TL. PMID: 23223118.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    85. Alfentanil: correlations between absence of effect upon subcutaneous mast cells and absence of granuloma formation after intrathecal infusion in the dog. Neuromodulation. 2013 Sep-Oct; 16(5):459-66; discussion 466. Yaksh TL, Steinauer JJ, Veesart SL, Malkmus SA. PMID: 23170763.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    86. Development and validation of an automated system for detection and assessment of scratching in the rodent. J Neurosci Methods. 2012 Oct 15; 211(1):1-10. Marino M, Huang P, Malkmus S, Robertshaw E, Mac EA, Shatterman Y, Yaksh TL. PMID: 22971351.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    87. Polyanalgesic Consensus Conference--2012: recommendations to reduce morbidity and mortality in intrathecal drug delivery in the treatment of chronic pain. Neuromodulation. 2012 Sep-Oct; 15(5):467-82; discussion 482. Deer TR, Levy R, Prager J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, Kumar K, Leong M, Liem L, McDowell GC, Panchal S, Rauck R, Saulino M, Sitzman BT, Staats P, Stanton-Hicks M, Stearns L, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. PMID: 22849581.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    88. Characteristics of distribution of morphine and metabolites in cerebrospinal fluid and plasma with chronic intrathecal morphine infusion in humans. Anesth Analg. 2012 Oct; 115(4):797-804. Wallace M, Yaksh TL. PMID: 22822192.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    89. Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12728-33. Lampa J, Westman M, Kadetoff D, Agréus AN, Le Maître E, Gillis-Haegerstrand C, Andersson M, Khademi M, Corr M, Christianson CA, Delaney A, Yaksh TL, Kosek E, Svensson CI. PMID: 22802629.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCTClinical Trials
    90. Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data. Anesth Analg. 2012 Sep; 115(3):638-62. Walker SM, Yaksh TL. PMID: 22798528.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    91. Polyanalgesic Consensus Conference 2012: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation. 2012 Sep-Oct; 15(5):436-64; discussion 464-6. Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, Kumar K, Leong M, Liem L, McDowell GC, Panchal S, Rauck R, Saulino M, Sitzman BT, Staats P, Stanton-Hicks M, Stearns L, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. PMID: 22748024.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    92. Pharmacokinetic analysis of ziconotide (SNX-111), an intrathecal N-type calcium channel blocking analgesic, delivered by bolus and infusion in the dog. Neuromodulation. 2012 Nov-Dec; 15(6):508-19; discussion 519. Yaksh TL, de Kater A, Dean R, Best BM, Miljanich GP. PMID: 22748108.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    93. Perineural local anesthetic and adjuvant action: the meaning of an ex vivo data set for efficacy and safety. Reg Anesth Pain Med. 2012 Jul-Aug; 37(4):366-8. Yaksh TL, Ilfeld BM, Wiese AJ. PMID: 22660488.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    94. Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial. Ann Intern Med. 2012 Apr 17; 156(8):551-9. Cohen SP, White RL, Kurihara C, Larkin TM, Chang A, Griffith SR, Gilligan C, Larkin R, Morlando B, Pasquina PF, Yaksh TL, Nguyen C. PMID: 22508732.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    95. Polyanalgesic Consensus Conference--2012: consensus on diagnosis, detection, and treatment of catheter-tip granulomas (inflammatory masses). Neuromodulation. 2012 Sep-Oct; 15(5):483-95; discussion 496. Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, Kumar K, Leong M, Liem L, McDowell GC, Panchal S, Rauck R, Saulino M, Sitzman BT, Staats P, Stanton-Hicks M, Stearns L, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. PMID: 22494332.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    96. Polyanalgesic Consensus Conference--2012: recommendations on trialing for intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation. 2012 Sep-Oct; 15(5):420-35; discussion 435. Deer TR, Prager J, Levy R, Burton A, Buchser E, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs M, Kim P, Kumar K, Leong M, Liem L, McDowell G, Panchal SJ, Rauck R, Saulino M, Staats P, Stanton-Hicks M, Stearns L, Sitzman BT, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. PMID: 22494357.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    97. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6721-6. Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL. PMID: 22493235.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    98. Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity. Anesth Analg. 2012 Aug; 115(2):450-60. Walker SM, Grafe M, Yaksh TL. PMID: 22467896.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    99. Safety assessment and pharmacokinetics of intrathecal methylprednisolone acetate in dogs. Anesthesiology. 2012 Jan; 116(1):170-81. Rijsdijk M, van Wijck AJ, Kalkman CJ, Meulenhoff PC, Grafe MR, Steinauer J, Yaksh TL. PMID: 22139590.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    100. K/BxN serum transfer arthritis as a model of inflammatory joint pain. Methods Mol Biol. 2012; 851:249-60. Christianson CA, Corr M, Yaksh TL, Svensson CI. PMID: 22351097.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    101. Effects of long term polyarthritis and subsequent NSAID treatment on activity with disassociation of tactile allodynia in the mouse. Neurocomputing. 2012 May 01; 84:47-52. Suhail MS, Christianson C, Koehrn F, Malkmus SA, Mitchell W, Corr M, Yaksh TL. PMID: 22547902.
      View in: PubMed   Mentions:
    102. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain. 2011 Dec; 152(12):2881-2891. Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, Yaksh TL. PMID: 22019135.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    103. The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats. J Anesth. 2011 Dec; 25(6):884-91. Kim HJ, Seol TK, Lee HJ, Yaksh TL, Jun JH. PMID: 21983967.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    104. Transient tactile allodynia following intrathecal puncture in mouse: contributions of Toll-like receptor signaling. Neurosci Lett. 2011 Oct 31; 504(3):215-8. Stokes JA, Corr M, Yaksh TL. PMID: 21964382.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    105. A brief comparison of the pathophysiology of inflammatory versus neuropathic pain. Curr Opin Anaesthesiol. 2011 Aug; 24(4):400-7. Xu Q, Yaksh TL. PMID: 21659872.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    106. Care to wrestle with a Brazilian armed spider? Pain. 2011 Oct; 152(10):2193-2195. Yaksh TL. PMID: 21782344.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    107. Regulation of spinal substance p release by intrathecal calcium channel blockade. Anesthesiology. 2011 Jul; 115(1):153-64. Takasusuki T, Yaksh TL. PMID: 21577088.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    108. Spinal toxins can have persistent adverse effects. Pain Med. 2011 Jul; 12(7):991-2. Yaksh TL. PMID: 21752177.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    109. Spinal botulinum neurotoxin B: effects on afferent transmitter release and nociceptive processing. PLoS One. 2011 Apr 29; 6(4):e19126. Huang PP, Khan I, Suhail MS, Malkmus S, Yaksh TL. PMID: 21559464.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    110. The effects of intrathecal and systemic gabapentin on spinal substance P release. Anesth Analg. 2011 Apr; 112(4):971-6. Takasusuki T, Yaksh TL. PMID: 21385982.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    111. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. J Neurosci. 2011 Feb 09; 31(6):2113-24. Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL. PMID: 21307248.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    112. Suppression of stretch reflex activity after spinal or systemic treatment with AMPA receptor antagonist NGX424 in rats with developed baclofen tolerance. Br J Pharmacol. 2010 Nov; 161(5):976-85. Oshiro M, Hefferan MP, Kakinohana O, Lukacova N, Sugahara K, Yaksh TL, Marsala M. PMID: 20977450.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    113. Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis. Pain. 2010 Nov; 151(2):394-403. Christianson CA, Corr M, Firestein GS, Mobargha A, Yaksh TL, Svensson CI. PMID: 20739123.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    114. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res. 2010 Sep 17; 1352:83-93. Peters CM, Hayashida K, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC. PMID: 20637741.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    115. Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase. Anesth Analg. 2010 Aug; 111(2):554-60. Matsui T, Svensson CI, Hirata Y, Mizobata K, Hua XY, Yaksh TL. PMID: 20610553.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    116. Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome. Anesthesiology. 2010 Jul; 113(1):147-59. Walker SM, Westin BD, Deumens R, Grafe M, Yaksh TL. PMID: 20526188.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    117. Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat. Anesthesiology. 2010 Jul; 113(1):183-99. Westin BD, Walker SM, Deumens R, Grafe M, Yaksh TL. PMID: 20526189.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    118. Assessment of canine sensory function by using sine-wave electrical stimuli paradigm. Physiol Behav. 2010 Oct 05; 101(3):327-30. Watabiki T, Nagakura Y, Wegner K, Kakimoto S, Tozier NA, Malkmus SA, Yaksh TL. PMID: 20570687.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    119. Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. J Neurochem. 2010 Aug; 114(4):981-93. Buczynski MW, Svensson CI, Dumlao DS, Fitzsimmons BL, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA. PMID: 20492349.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    120. Effects of intrathecal ketorolac on human experimental pain. Anesthesiology. 2010 May; 112(5):1216-24. Eisenach JC, Curry R, Tong C, Houle TT, Yaksh TL. PMID: 20395821.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    121. Role of spinal cyclooxygenase in human postoperative and chronic pain. Anesthesiology. 2010 May; 112(5):1225-33. Eisenach JC, Curry R, Rauck R, Pan P, Yaksh TL. PMID: 20395820.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    122. Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs. Cell Transplant. 2010; 19(9):1103-22. Usvald D, Vodicka P, Hlucilova J, Prochazka R, Motlik J, Kuchorova K, Johe K, Marsala S, Scadeng M, Kakinohana O, Navarro R, Santa M, Hefferan MP, Yaksh TL, Marsala M. PMID: 20412634.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    123. Consent contraindicated? Science. 2010 Apr 02; 328(5974):45; author reply 45. Yaksh TL, Eisenach JC, Shafer SL. PMID: 20360092.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    124. The need for a journal policy on intrathecal, epidural, and perineural administration of non-approved drugs. Pain. 2010 Jun; 149(3):417-419. Eisenach JC, Shafer SL, Yaksh T. PMID: 20227830.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    125. Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression. Neuroreport. 2010 Mar 10; 21(4):313-7. Fitzsimmons BL, Zattoni M, Svensson CI, Steinauer J, Hua XY, Yaksh TL. PMID: 20134354.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    126. Preclinical research on persistent postsurgical pain: what we don't know, but should start studying. Anesthesiology. 2010 Mar; 112(3):511-3. Scholz J, Yaksh TL. PMID: 20124975.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    127. Correlation between myoclonus and the 3-glucuronide metabolites in patients treated with morphine or hydromorphone: a pilot study. J Opioid Manag. 2010 Mar-Apr; 6(2):87-94. McCann S, Yaksh TL, von Gunten CF. PMID: 20481173.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    128. [Vacuoles: a hollow threat?]. Can J Anaesth. 2010 Mar; 57(3):195-200. Yaksh TL. PMID: 20054677.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    129. Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. Neurosci Lett. 2010 Feb 05; 470(1):6-9. Park P, Schachter S, Yaksh T. PMID: 20026382.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    130. Behavioral models of pain states evoked by physical injury to the peripheral nerve. Neurotherapeutics. 2009 Oct; 6(4):609-19. Sorkin LS, Yaksh TL. PMID: 19789066.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    131. Randomized, double-blind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica. Anesthesiology. 2009 May; 110(5):1116-26. Cohen SP, Bogduk N, Dragovich A, Buckenmaier CC, Griffith S, Kurihara C, Raymond J, Richter PJ, Williams N, Yaksh TL. PMID: 19387178.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    132. The end of postoperative pain--a fast-approaching possibility? And, if so, will we be ready? Reg Anesth Pain Med. 2009 Mar-Apr; 34(2):85-7. Ilfeld BM, Yaksh TL. PMID: 19282704.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    133. Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology. 2009 Apr; 136(4):1339-48, e1-2. Bradesi S, Svensson CI, Steinauer J, Pothoulakis C, Yaksh TL, Mayer EA. PMID: 19249394.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    134. Spinal antinociceptive action of loperamide is mediated by opioid receptors in the formalin test in rats. Neurosci Lett. 2008 Dec 31; 448(3):260-2. Ray SB, Yaksh TL. PMID: 18973791.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    135. Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain. Pharmacol Biochem Behav. 2008 Oct; 90(4):664-75. Svensson CI, Medicherla S, Malkmus S, Jiang Y, Ma JY, Kerr I, Brainin-Mattos J, Powell HC, Luo ZD, Chakravarty S, Dugar S, Higgins LS, Protter AA, Yaksh TL. PMID: 18584857.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    136. Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12599-604. Ilieva HS, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW. PMID: 18719118.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    137. The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy. Pain. 2008 Oct 31; 139(3):569-577. Nagakura Y, Jones TL, Malkmus SA, Sorkin L, Yaksh TL. PMID: 18692315.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    138. Acetaminophen prevents hyperalgesia in central pain cascade. Neurosci Lett. 2008 Sep 05; 442(1):50-3. Crawley B, Saito O, Malkmus S, Fitzsimmons B, Hua XY, Yaksh TL. PMID: 18601979.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    139. Toxicology profile of N-methyl-D-aspartate antagonists delivered by intrathecal infusion in the canine model. Anesthesiology. 2008 May; 108(5):938-49. Yaksh TL, Tozier N, Horais KA, Malkmus S, Rathbun M, Lafranco L, Eisenach J. PMID: 18431131.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    140. The effect of acupuncture duration on analgesia and peripheral sensory thresholds. BMC Complement Altern Med. 2008 May 01; 8:18. Leung AY, Kim SJ, Schulteis G, Yaksh T. PMID: 18452622.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    141. Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. Neuropharmacology. 2008 Feb; 54(2):269-79. Khan IM, Wart CV, Singletary EA, Stanislaus S, Deerinck T, Yaksh TL, Printz MP. PMID: 18037142.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    142. Spinal astrocyte glutamate receptor 1 overexpression after ischemic insult facilitates behavioral signs of spasticity and rigidity. J Neurosci. 2007 Oct 17; 27(42):11179-91. Hefferan MP, Kucharova K, Kinjo K, Kakinohana O, Sekerkova G, Nakamura S, Fuchigami T, Tomori Z, Yaksh TL, Kurtz N, Marsala M. PMID: 17942713.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    143. Development of a canine nociceptive thermal escape model. J Neurosci Methods. 2008 Feb 15; 168(1):88-97. Wegner K, Horais KA, Tozier NA, Rathbun ML, Shtaerman Y, Yaksh TL. PMID: 18054083.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCTClinical Trials
    144. Neonates have a spinal alpha receptor too, as do adults. Br J Pharmacol. 2007 Aug; 151(8):1139-40. Yaksh TL. PMID: 17641678.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    145. Mandating two-year regional anesthesia fellowships: fanning the academic flame or extinguishing it? Reg Anesth Pain Med. 2007 Jul-Aug; 32(4):275-9. Ilfeld BM, Yaksh TL, Neal JM. PMID: 17720109.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    146. Determination of current threshold for paw withdrawal with sine-wave electrical stimulation in rats: effect of drugs and alteration in acute inflammation. Pain. 2008 Feb; 134(3):293-301. Nagakura Y, Malkmus S, Yaksh TL. PMID: 17583428.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    147. An assessment of the antinociceptive efficacy of intrathecal and epidural contulakin-G in rats and dogs. Anesth Analg. 2007 Jun; 104(6):1505-13, table of contents. Allen JW, Hofer K, McCumber D, Wagstaff JD, Layer RT, McCabe RT, Yaksh TL. PMID: 17513650.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    148. The pharmacokinetics of the conopeptide contulakin-G (CGX-1160) after intrathecal administration: an analysis of data from studies in beagles. Anesth Analg. 2007 Jun; 104(6):1514-20, table of contents. Kern SE, Allen J, Wagstaff J, Shafer SL, Yaksh T. PMID: 17513651.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    149. Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation. Eur J Neurosci. 2007 May; 25(10):2964-72. Tang Q, Svensson CI, Fitzsimmons B, Webb M, Yaksh TL, Hua XY. PMID: 17561811.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    150. Descending serotonergic facilitation of spinal ERK activation and pain behavior. FEBS Lett. 2006 Dec 11; 580(28-29):6629-34. Svensson CI, Tran TK, Fitzsimmons B, Yaksh TL, Hua XY. PMID: 17113581.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    151. The electrophysiology of de qi sensations. J Altern Complement Med. 2006 Oct; 12(8):743-50. Leung AY, Park J, Schulteis G, Duann JR, Yaksh T. PMID: 17034280.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    152. Opiate pharmacology of intrathecal granulomas. Anesthesiology. 2006 Sep; 105(3):590-8. Allen JW, Horais KA, Tozier NA, Yaksh TL. PMID: 16931994.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    153. Time course and role of morphine dose and concentration in intrathecal granuloma formation in dogs: a combined magnetic resonance imaging and histopathology investigation. Anesthesiology. 2006 Sep; 105(3):581-9. Allen JW, Horais KA, Tozier NA, Wegner K, Corbeil JA, Mattrey RF, Rossi SS, Yaksh TL. PMID: 16931993.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    154. Covariance among age, spinal p38 MAP kinase activation and allodynia. J Pain. 2006 May; 7(5):337-45. Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin LS. PMID: 16632323.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    155. Characterization of interference with 6 commercial delta9-tetrahydrocannabinol immunoassays by efavirenz (glucuronide) in urine. Clin Chem. 2006 May; 52(5):896-7. Rossi S, Yaksh T, Bentley H, van den Brande G, Grant I, Ellis R. PMID: 16638958.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    156. Cancer-related bone pain is attenuated by a systemically available delta-opioid receptor agonist. Pain. 2006 May; 122(1-2):174-81. Brainin-Mattos J, Smith ND, Malkmus S, Rew Y, Goodman M, Taulane J, Yaksh TL. PMID: 16545911.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    157. Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs. Toxicol Sci. 2006 May; 91(1):286-98. Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL. PMID: 16500924.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    158. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur J Neurosci. 2006 Feb; 23(3):627-36. Shi TJ, Hua XY, Lu X, Malkmus S, Kinney J, Holmberg K, Wirz S, Ceccatelli S, Yaksh T, Bartfai T, Hökfelt T. PMID: 16487144.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    159. Calcium channels as therapeutic targets in neuropathic pain. J Pain. 2006 Jan; 7(1 Suppl 1):S13-30. Yaksh TL. PMID: 16426997.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    160. Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia. Eur J Neurosci. 2005 Nov; 22(10):2431-40. Hua XY, Svensson CI, Matsui T, Fitzsimmons B, Yaksh TL, Webb M. PMID: 16307586.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    161. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. J Pharmacol Exp Ther. 2006 Jan; 316(1):466-75. Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA. PMID: 16203828.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    162. Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. Neuropeptides. 2005 Oct; 39(5):485-94. Svensson CI, Hua XY, Powell HC, Lai J, Porreca F, Yaksh TL. PMID: 16176831.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    163. Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain. 2005 Nov; 118(1-2):112-24. Nielsen CK, Lewis RJ, Alewood D, Drinkwater R, Palant E, Patterson M, Yaksh TL, McCumber D, Smith MT. PMID: 16154696.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    164. Unexpected pain in a dog: aberration or worthy of a citation? Agree to disagree. Lab Anim (NY). 2005 Sep; 34(8):19. Torchia M, Yaksh T. PMID: 16136070.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    165. The effect of Ting point (tendinomuscular meridians) electroacupuncture on thermal pain: a model for studying the neuronal mechanism of acupuncture analgesia. J Altern Complement Med. 2005 Aug; 11(4):653-61. Leung A, Khadivi B, Duann JR, Cho ZH, Yaksh T. PMID: 16131289.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    166. Qualitative and quantitative characterization of the thermal grill. Pain. 2005 Jul; 116(1-2):26-32. Leung AY, Wallace MS, Schulteis G, Yaksh TL. PMID: 15935558.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    167. Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence. J Pharmacol Exp Ther. 2005 Sep; 314(3):1362-9. Gu G, Kondo I, Hua XY, Yaksh TL. PMID: 15908510.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    168. Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. J Neurosci. 2005 Apr 06; 25(14):3651-60. Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL. PMID: 15814796.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    169. Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. Br J Pharmacol. 2005 Apr; 144(7):940-52. Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. PMID: 15685208.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    170. Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. J Neurochem. 2005 Mar; 92(6):1508-20. Svensson CI, Fitzsimmons B, Azizi S, Powell HC, Hua XY, Yaksh TL. PMID: 15748168.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    171. Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia. Eur J Neurosci. 2004 Nov; 20(9):2401-14. Marsala M, Kakinohana O, Yaksh TL, Tomori Z, Marsala S, Cizkova D. PMID: 15525281.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    172. Ablation of primary afferent terminals reduces nicotinic receptor expression and the nociceptive responses to nicotinic agonists in the spinal cord. J Neurocytol. 2004 Sep; 33(5):543-56. Khan IM, Wennerholm M, Singletary E, Polston K, Zhang L, Deerinck T, Yaksh TL, Taylor P. PMID: 15906161.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    173. A preclinical post laminectomy rat model mimics the human post laminectomy syndrome. J Neurosci Methods. 2004 Aug 30; 137(2):283-9. Massie JB, Huang B, Malkmus S, Yaksh TL, Kim CW, Garfin SR, Akeson WH. PMID: 15262072.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    174. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10470-5. Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J. PMID: 15240875.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    175. Intrathecal protease-activated receptor stimulation produces thermal hyperalgesia through spinal cyclooxygenase activity. J Pharmacol Exp Ther. 2004 Oct; 311(1):356-63. Koetzner L, Gregory JA, Yaksh TL. PMID: 15175421.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    176. The use of intrathecal midazolam in humans: a case study of process. Anesth Analg. 2004 Jun; 98(6):1536-45, table of contents. Yaksh TL, Allen JW. PMID: 15155302.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    177. Preclinical insights into the implementation of intrathecal midazolam: a cautionary tale. Anesth Analg. 2004 Jun; 98(6):1509-11. Yaksh TL, Allen JW. PMID: 15155298.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    178. Intrathecal ketorolac in dogs and rats. Toxicol Sci. 2004 Aug; 80(2):322-34. Yaksh TL, Horais KA, Tozier N, Rathbun M, Richter P, Rossi S, Grafe M, Tong C, Meschter C, Cline JM, Eisenach J. PMID: 15141096.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    179. Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia. J Neurosci. 2004 Mar 17; 24(11):2727-32. Ghilardi JR, Svensson CI, Rogers SD, Yaksh TL, Mantyh PW. PMID: 15028765.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    180. Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. J Neurosci. 2004 Feb 11; 24(6):1451-8. Koetzner L, Hua XY, Lai J, Porreca F, Yaksh T. PMID: 14960618.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    181. Intrathecal but not intravenous opioids release adenosine from the spinal cord. J Pain. 2004 Feb; 5(1):64-8. Eisenach JC, Hood DD, Curry R, Sawynok J, Yaksh TL, Li X. PMID: 14975380.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    182. Intrathecal catheterization and drug delivery in the rat. Methods Mol Med. 2004; 99:109-21. Malkmus SA, Yaksh TL. PMID: 15131333.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    183. Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Exp Neurol. 2004 Jan; 185(1):160-8. Schäfers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C. PMID: 14697327.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    184. Tissue injury models of persistent nociception in rats. Methods Mol Med. 2004; 99:25-34. Allen JW, Yaksh TL. PMID: 15131326.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    185. Assessment of acute thermal nociception in laboratory animals. Methods Mol Med. 2004; 99:11-23. Allen JW, Yaksh TL. PMID: 15131325.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    186. Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways. J Comp Neurol. 2003 Dec 01; 467(1):44-59. Khan I, Osaka H, Stanislaus S, Calvo RM, Deerinck T, Yaksh TL, Taylor P. PMID: 14574679.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    187. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther. 2004 Feb; 308(2):574-82. Hua XY, Hayes CS, Hofer A, Fitzsimmons B, Kilk K, Langel U, Bartfai T, Yaksh TL. PMID: 14610237.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    188. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003 Sep; 86(6):1534-44. Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. PMID: 12950462.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    189. Chronically infused intrathecal morphine in dogs. Anesthesiology. 2003 Jul; 99(1):174-87. Yaksh TL, Horais KA, Tozier NA, Allen JW, Rathbun M, Rossi SS, Sommer C, Meschter C, Richter PJ, Hildebrand KR. PMID: 12826858.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    190. Preclinical work leading to the development of spinal analgesia. Anesthesiology. 2003 Jul; 99(1):224-5. Yaksh TL. PMID: 12826864.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    191. A double-lumen intrathecal catheter for studies of modulation of spinal opiate tolerance. J Neurosci Methods. 2003 Jun 30; 126(2):165-73. Hayes CS, Mulkmus SA, Cizkova D, Yaksh TL, Hua XY. PMID: 12814841.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    192. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosci. 2003 Jun 15; 23(12):5031-40. South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage FH, Yaksh TL, Woolf CJ, Heinemann SF, Inturrisi CE. PMID: 12832526.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    193. Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia. Neuroreport. 2003 Jun 11; 14(8):1153-7. Svensson CI, Hua XY, Protter AA, Powell HC, Yaksh TL. PMID: 12821799.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    194. Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci. 2003 Apr 01; 23(7):3028-38. Schäfers M, Lee DH, Brors D, Yaksh TL, Sorkin LS. PMID: 12684490.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    195. Neuraxial morphine may trigger transient motor dysfunction after a noninjurious interval of spinal cord ischemia: a clinical and experimental study. Anesthesiology. 2003 Apr; 98(4):862-70. Kakinohana M, Marsala M, Carter C, Davison JK, Yaksh TL. PMID: 12657847.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    196. Rapid quantification of the non-competitive NMDA antagonist MK-801 in canine cerebrospinal fluid and plasma by capillary gas chromatography-nitrogen phosphorus detection. J Pharm Biomed Anal. 2003 Feb 26; 31(2):243-50. Rossi S, Yaksh T. PMID: 12609663.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    197. Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog. J Pharmacol Exp Ther. 2003 Feb; 304(2):827-32. Svensson CI, Rew Y, Malkmus S, Schiller PW, Taulane JP, Goodman M, Yaksh TL. PMID: 12538839.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    198. Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats. Br J Pharmacol. 2003 Feb; 138(4):689-97. Ibuki T, Marsala M, Masuyama T, Yaksh TL. PMID: 12598423.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    199. Effects of chronic intrathecal infusion of a partial differential opioid agonist in dogs. Toxicol Sci. 2003 Feb; 71(2):263-75. Horais K, Hruby V, Rossi S, Cizkova D, Meschter C, Dorr R, Yaksh TL. PMID: 12563112.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    200. Epidural ketamine in healthy children--what's the point? Anesth Analg. 2003 Feb; 96(2):626; author reply 626-7. Eisenach JC, Yaksh TL. PMID: 12538224.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    201. Inflammatory masses associated with intrathecal drug infusion: a review of preclinical evidence and human data. Pain Med. 2002 Dec; 3(4):300-12. Yaksh TL, Hassenbusch S, Burchiel K, Hildebrand KR, Page LM, Coffey RJ. PMID: 15099235.
      View in: PubMed   Mentions: 18     Fields:    
    202. Safety in numbers: how do we study toxicity of spinal analgesics? Anesthesiology. 2002 Nov; 97(5):1047-9. Eisenach JC, Yaksh TL. PMID: 12411784.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    203. Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness. Physiol Genomics. 2002 Oct 29; 11(2):65-72. Khan IM, Singletary E, Alemayehu A, Stanislaus S, Printz MP, Yaksh TL, Taylor P. PMID: 12388796.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    204. Phase I safety assessment of intrathecal ketorolac. Pain. 2002 Oct; 99(3):599-604. Eisenach JC, Curry R, Hood DD, Yaksh TL. PMID: 12406536.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    205. Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain. Pain. 2002 Oct; 99(3):397-406. Luger NM, Sabino MAC, Schwei MJ, Mach DB, Pomonis JD, Keyser CP, Rathbun M, Clohisy DR, Honore P, Yaksh TL, Mantyh PW. PMID: 12406514.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    206. Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury. Exp Brain Res. 2002 Dec; 147(4):456-63. Cizkova D, Marsala J, Lukacova N, Marsala M, Jergova S, Orendacova J, Yaksh TL. PMID: 12444477.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    207. Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands. J Med Chem. 2002 Aug 15; 45(17):3746-54. Rew Y, Malkmus S, Svensson C, Yaksh TL, Chung NN, Schiller PW, Cassel JA, DeHaven RN, Taulane JP, Goodman M. PMID: 12166947.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    208. Rapid quantification of the delta-opioid receptor selective enkephalin DPDPE in canine cerebrospinal fluid by liquid chromatography--mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 25; 772(1):73-9. Rossi S, Yaksh T. PMID: 12016017.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    209. Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury. Anesth Analg. 2002 Apr; 94(4):968-74, table of contents. Nozaki-Taguchi N, Yaksh TL. PMID: 11916806.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    210. Pharmacology of spinal glutamatergic receptors in post-thermal injury-evoked tactile allodynia and thermal hyperalgesia. Anesthesiology. 2002 Mar; 96(3):617-26. Nozaki-Taguchi N, Yaksh TL. PMID: 11873037.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    211. Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve. J Neurosci. 2002 Jan 15; 22(2):536-45. Schäfers M, Geis C, Brors D, Yaksh TL, Sommer C. PMID: 11784800.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    212. Future advances in pain pharmacology: what does the present say about the future? Proc West Pharmacol Soc. 2002; 45:211-8. Yaksh TL. PMID: 12434582.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    213. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annu Rev Pharmacol Toxicol. 2002; 42:553-83. Svensson CI, Yaksh TL. PMID: 11807183.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    214. Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia. J Clin Pharmacol. 2002 Jan; 42(1):70-80. Wallace MS, Ridgeway B, Leung A, Schulteis G, Yaksh TL. PMID: 11808827.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    215. Effects of continuous lumbar intrathecal infusion of leptin in rats on weight regulation. Neuroscience. 2002; 110(4):703-10. Yaksh TL, Scott B, LeBel CL. PMID: 11934477.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    216. The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. J Neurosci. 2001 Aug 15; 21(16):5847-53. Yaksh TL, Dirig DM, Conway CM, Svensson C, Luo ZD, Isakson PC. PMID: 11487607.
      View in: PubMed   Mentions: 61     Fields:    Translation:Animals
    217. Vincristine-induced allodynia in the rat. Pain. 2001 Jul; 93(1):69-76. Nozaki-Taguchi N, Chaplan SR, Higuera ES, Ajakwe RC, Yaksh TL. PMID: 11406340.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    218. An automated flinch detecting system for use in the formalin nociceptive bioassay. J Appl Physiol (1985). 2001 Jun; 90(6):2386-402. Yaksh TL, Ozaki G, McCumber D, Rathbun M, Svensson C, Malkmus S, Yaksh MC. PMID: 11356806.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    219. Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion. Pain. 2000 Apr; 85(3):395-404. Granados-Soto V, Kalcheva I, Hua XY, Newton A, Yaksh TL. PMID: 10781912.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    220. Regulation of spinal nociceptive processing: where we went when we wandered onto the path marked by the gate. Pain. 1999 Aug; Suppl 6:S149-S152. Yaksh TL. PMID: 10491984.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    221. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):7680-6. Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, Marsala M. PMID: 10393880.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    222. Pharmacokinetics and efficacy of epidurally delivered sustained-release encapsulated morphine in dogs. Anesthesiology. 1999 May; 90(5):1402-12. Yaksh TL, Provencher JC, Rathbun ML, Kohn FR. PMID: 10319789.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    223. Mechanism of action of nonsteroidal anti-inflammatory drugs. Cancer Invest. 1998; 16(7):509-27. Yaksh TL, Dirig DM, Malmberg AB. PMID: 9774958.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    224. Computer-controlled lidocaine infusion for the evaluation of neuropathic pain after peripheral nerve injury. Pain. 1996 Jul; 66(1):69-77. Wallace MS, Dyck BJ, Rossi SS, Yaksh TL. PMID: 8857633.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    225. Differential right shifts in the dose-response curve for intrathecal morphine and sufentanil as a function of stimulus intensity. Pain. 1995 Sep; 62(3):321-328. Dirig DM, Yaksh TL. PMID: 8657432.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    226. Effect of continuous intrathecal infusion of omega-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain. 1995 Jan; 60(1):83-90. Malmberg AB, Yaksh TL. PMID: 7715945.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    227. Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. Pain. 1994 Sep; 58(3):413-420. Calcutt NA, Malmberg AB, Yamamoto T, Yaksh TL. PMID: 7838591.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    228. Effects of colchicine applied to the peripheral nerve on the thermal hyperalgesia evoked with chronic nerve constriction. Pain. 1993 Nov; 55(2):227-233. Yamamoto T, Yaksh TL. PMID: 7508592.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    229. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain. 1993 Sep; 54(3):291-300. Malmberg AB, Yaksh TL. PMID: 8233543.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    230. Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801. Pain. 1993 Jul; 54(1):79-84. Yamamoto T, Yaksh TL. PMID: 8378105.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    231. Effects of intrathecal capsaicin and an NK-1 antagonist, CP,96-345, on the thermal hyperalgesia observed following unilateral constriction of the sciatic nerve in the rat. Pain. 1992 Dec; 51(3):329-334. Yamamoto T, Yaksh TL. PMID: 1337198.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    232. Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists. Pain. 1992 Apr; 49(1):121-128. Yamamoto T, Yaksh TL. PMID: 1594273.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    233. Leakage of fluid after epidural injection. Pain. 1991 Mar; 44(3):325. Yaksh TL. PMID: 2052401.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    234. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain. 1989 Apr; 37(1):111-123. Yaksh TL. PMID: 2542867.
      View in: PubMed   Mentions: 126     Fields:    Translation:Animals
    235. Retrospective consideration of the doses of morphine given intrathecally by chronic infusion in 163 patients by 19 physicians. Pain. 1987 Nov; 31(2):211-223. Yaksh TL, Onofrio BM. PMID: 3431881.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    236. The analgesic efficacy of intrathecal D-Ala2-D-Leu5-enkephalin in cancer patients with chronic pain. Pain. 1985 Nov; 23(3):213-221. Moulin DE, Max MB, Kaiko RF, Inturrisi CE, Maggard J, Yaksh TL, Foley KM. PMID: 3906516.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    237. Spinal cord monoamines modulate the antinociceptive effects of vaginal stimulation in rats. Pain. 1983 Jun; 16(2):155-166. Steinman JL, Komisaruk BR, Yaksh TL, Tyce GM. PMID: 6877846.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    238. Peripheral and central substrates involved in the rostrad transmission of nociceptive information. Pain. 1982 May; 13(1):1-85. Yaksh TL, Hammond DL. PMID: 6287384.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    239. The antinociceptive effects of epidural opiates in the cat: studies of the pharmacology and the effects of lipophilicity in spinal analgesia. Pain. 1982 Apr; 12(4):343-356. Tung AS, Yaksh TL. PMID: 7099701.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    240. Narcotic analgestics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques. Pain. 1978 Apr; 4(4):299-359. Yaksh TL, Rudy TA. PMID: 25403.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    241. Concurrent mapping of brain sites for sensitivity to the direct application of morphine and focal electrical stimulation in the production of antinociception in the rat. Pain. 1977 Oct; 4(1):23-40. Yeung JC, Yaksh TL, Rudy TA. PMID: 927879.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    Tony's Networks
    Concepts (841)
    Derived automatically from this person's publications.
    _
    Co-Authors (50)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _