Tony Yaksh

Title(s)Recall Faculty, Anesthesiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    B.S.Georgia Institute of Technology
    M.S.University of Georgia
    Ph.D.Purdue University
    Collapse Awards and Honors
    1995American Society of Anesthesiology (ASA) Award for Excellence in Research;
    1996Emmanuel Papper Lecturer, Columbia Presbyterian Hospital
    1998Joris De Castro Memorial Lecture - Belgian Society of Anaesthesia and Reanimation
    1998American Academy of Pain Medicine, Award for Outstanding Contributions to Pain Medicine
    1999UCSD Chancellor’s Associates Faculty Excellence Award in Research
    1999American Academy of Pain Management, The John Liebeskind Award for Pain Research
    2000Swedish Society of Medicine, Torsten Gordh lecturer
    2001New York Society of Anesthesiologists Rovenstine Lecturer
    2007Javitz Award in Neuroscience; National Institute of Neurological, Communicative Diseases and Stroke
    2007Schueler Distinguished Lecturer award, Tulane University
    2007Seldon Memorial Lecturer award, International Anesthesia Research Society
    2007German Promotion Award for Pain Research and Therapy, German Pain Association
    2008ohn J. Bonica Distinguished Lecturer, International Association for the Study of Pain
    2012Presidential Commendation, World Institute of Pain
    2015Lifetime achievement award (North American Neuromodulation Society - NANS)
    2017Spain Distinguished Service Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Pre-clinical evaluation of DT-001, a small molecule antagonist of MD2-TLR4 for utility in the treatment of pain.
    NIH R41NS113717Sep 30, 2019 - Aug 31, 2021
    Role: Principal Investigator
    New Approach to Atopic Dermatitis
    NIH R43AR072546Sep 1, 2018 - Aug 31, 2021
    Role: Co-Principal Investigator
    Reversal of preexisting neuropathic pain by spinal delivery of AIBP
    NIH R33NS104769Aug 1, 2018 - Jul 31, 2021
    Role: Co-Principal Investigator
    Reversal of preexisting neuropathic pain by spinal delivery of AIBP
    NIH R21NS104769Aug 1, 2018 - Jul 31, 2020
    Role: Co-Principal Investigator
    AIBP and regulation of neuropathic pain
    NIH R01NS102432Aug 15, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Sex, Stress and Immunity in the Acute to Chronic Pain Transition
    NIH R01NS099338Dec 15, 2016 - Nov 30, 2021
    Role: Principal Investigator
    Construction and Analysis of BoNT derivatives as Pain Specific Inhibitors
    NIH R21AI113580Aug 7, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Discovery of novel small molecule analgesics
    NIH R41NS086244May 15, 2014 - Dec 31, 2015
    Role: Principal Investigator
    Myelin Autoantigens in Neuropathic Pain
    NIH R01DE022757Jul 30, 2012 - Aug 31, 2023
    Role: Principal Investigator
    The role of selective brain penetrating GRPR antagonists in pruritis.
    NIH R21NS077348Sep 30, 2011 - Dec 30, 2013
    Role: Principal Investigator
    Pain Mechanisms and the Development of Analgesics
    NIH R13DA021484Mar 1, 2006 - Feb 28, 2007
    Role: Principal Investigator
    Characterization of Toxicity with Spinal Opiates
    NIH R01DA015353Jul 1, 2002 - Jun 30, 2020
    Role: Principal Investigator
    Spinal Galanin and its Receptors in Pain Processing
    NIH R01NS041954Jun 1, 2002 - May 31, 2006
    Role: Principal Investigator
    Neurobiology of Pain
    NIH T32NS007407Jul 1, 1997 - Jun 30, 2007
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Jul 1, 1996 - Apr 30, 2024
    Role: Co-Investigator
    PRECLINICAL TOXICOLOGY STUDIES OF NMDA ANTAGONISTS
    NIH R01NS033846Aug 1, 1994 - Jul 31, 1998
    Role: Principal Investigator
    NEW MODALITIES FOR TREATMENT OF PAIN AND DRUG ABUSE
    NIH P01DA006284Sep 30, 1989 - Mar 31, 2016
    Role: Co-Investigator
    Pain Evoked Release of Amino Acids and Prostanoids
    NIH R37NS016541Sep 1, 1988 - Feb 28, 2013
    Role: Principal Investigator
    PEPTIDE RELEASE FROM PERIPHERAL TERMINALS OF AFFERENTS
    NIH R01AI026249Apr 1, 1988 - Mar 31, 1992
    Role: Principal Investigator
    The Pharmacology of Spinal Analgesics
    NIH R01DA002110Jul 1, 1983 - Jan 31, 2016
    Role: Principal Investigator
    SPINAL PHARMACOLOGY OF BLADDER FUNCTION
    NIH R01NS019650Jul 1, 1983 - Jun 30, 1986
    Role: Principal Investigator
    PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    NIH R01NS016541Jul 1, 1980 - Dec 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Severe altered mentation due to cervicothoracic intrathecal pump after correction of cervical stenosis: a case report. Reg Anesth Pain Med. 2021 Sep 06. Sanghvi C, Su T, Yaksh TL, Copenhaver DJ, Klineberg EO, Jung MJ. PMID: 34489354.
      View in: PubMed   Mentions:    Fields:    
    2. Sex differences in neuroimmune and glial mechanisms of pain. Pain. 2021 08 01; 162(8):2186-2200. Gregus AM, Levine IS, Eddinger KA, Yaksh TL, Buczynski MW. PMID: 34256379.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Treating osteoarthritis pain: mechanisms of action of acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, and nerve growth factor antibodies. Postgrad Med. 2021 Jul 12; 1-16. D'Arcy Y, Mantyh P, Yaksh T, Donevan S, Hall J, Sadrarhami M, Viktrup L. PMID: 34252357.
      View in: PubMed   Mentions:    Fields:    
    4. Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain. J Exp Med. 2021 07 05; 218(7). Navia-Pelaez JM, Choi SH, Dos Santos Aggum Capettini L, Xia Y, Gonen A, Agatisa-Boyle C, Delay L, Gonçalves Dos Santos G, Catroli GF, Kim J, Lu JW, Saylor B, Winkels H, Durant CP, Ghosheh Y, Beaton G, Ley K, Kufareva I, Corr M, Yaksh TL, Miller YI. PMID: 33970188.
      View in: PubMed   Mentions: 1     Fields:    
    5. Long-lasting analgesia via targeted in situ repression of NaV1.7 in mice. Sci Transl Med. 2021 03 10; 13(584). Moreno AM, Alemán F, Catroli GF, Hunt M, Hu M, Dailamy A, Pla A, Woller SA, Palmer N, Parekh U, McDonald D, Roberts AJ, Goodwill V, Dryden I, Hevner RF, Delay L, Gonçalves Dos Santos G, Yaksh TL, Mali P. PMID: 33692134.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    6. Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis. Rheum Dis Clin North Am. 2021 05; 47(2):245-264. Delay L, Gonçalves Dos Santos G, Dias EV, Yaksh TL, Corr M. PMID: 33781493.
      View in: PubMed   Mentions:    Fields:    
    7. Lipid rafts in glial cells: role in neuroinflammation and pain processing: Thematic Review Series: Biology of Lipid Rafts. J Lipid Res. 2020 05; 61(5):655-666. Miller YI, Navia-Pelaez JM, Corr M, Yaksh TL. PMID: 33715813.
      View in: PubMed   Mentions:    Fields:    
    8. Unintended consequences of COVID-19 safety measures on patients with chronic knee pain forced to defer joint replacement surgery. Pain Rep. 2020 Nov-Dec; 5(6):e855. Cisternas AF, Ramachandran R, Yaksh TL, Nahama A. PMID: 33134751.
      View in: PubMed   Mentions:
    9. The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling. Sci Rep. 2020 09 24; 10(1):15596. Gonçalves Dos Santos G, Jimenéz-Andrade JM, Woller SA, Muñoz-Islas E, Ramírez-Rosas MB, Ohashi N, Ferreira Catroli G, Fujita Y, Yaksh TL, Corr M. PMID: 32973194.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    10. Topical Application of ASN008, a Permanently Charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset, and Long Duration of Action in a Mouse Model of Pruritus. J Pharmacol Exp Ther. 2020 09; 374(3):521-528. Ramachandran R, Thompson SK, Malkmus S, Mieda T, Lin JH, Gupta S, Yaksh TL. PMID: 32616515.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice. J Biol Chem. 2020 07 31; 295(31):10807-10821. Chernov AV, Hullugundi SK, Eddinger KA, Dolkas J, Remacle AG, Angert M, James BP, Yaksh TL, Strongin AY, Shubayev VI. PMID: 32532796.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Pharmacodynamics of intrathecal and epidural fadolmidine, an α2-adrenoceptor agonist, after bolus and infusion in dogs-comparison with clonidine. Naunyn Schmiedebergs Arch Pharmacol. 2020 08; 393(8):1459-1473. Leino T, Yaksh T, Horais K, Haapalinna A. PMID: 32179953.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    13. Neuraxial Cytokines in Pain States. Front Immunol. 2019; 10:3061. Gonçalves Dos Santos G, Delay L, Yaksh TL, Corr M. PMID: 32047493.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    14. Lipid rafts in glial cells: role in neuroinflammation and pain processing. J Lipid Res. 2020 05; 61(5):655-666. Miller YI, Navia-Pelaez JM, Corr M, Yaksh TL. PMID: 31862695.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    15. Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety. Pain. 2019 10; 160(10):2210-2220. Schmelz M, Mantyh P, Malfait AM, Farrar J, Yaksh T, Tive L, Viktrup L. PMID: 31145219.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    16. Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling. Anesthesiology. 2019 07; 131(1):132-147. Yaksh TL, Eddinger KA, Kokubu S, Wang Z, DiNardo A, Ramachandran R, Zhu Y, He Y, Weren F, Quang D, Malkmus SA, Lansu K, Kroeze WK, Eliceiri B, Steinauer JJ, Schiller PW, Gmeiner P, Page LM, Hildebrand KR. PMID: 31225809.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. Characterization of Effect of Repeated Bolus or Continuous Intrathecal Infusion of Morphine on Spinal Mass Formation in the Dog. Neuromodulation. 2019 Oct; 22(7):790-798. Hildebrand KR, Page LM, Billstrom TM, Steinauer JJ, Eddinger KA, Arjomand S, Yaksh TL. PMID: 31124198.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    18. Unilateral Epidural Targeting of Resiniferatoxin Induces Bilateral Neurolysis of Spinal Nociceptive Afferents. Pain Med. 2019 05 01; 20(5):897-906. Unger MD, Pleticha J, Steinauer J, Kanwar R, Diehn F, LaVallee KT, Banck MS, Jones B, Yaksh TL, Maus TP, Beutler AS. PMID: 30590777.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    19. Characterization of Analgesic Actions of the Chronic Intrathecal Infusion of H-Dmt-D-Arg-Phe-Lys-NH2 in Rat. Neuromodulation. 2019 Oct; 22(7):781-789. Kokubu S, Eddinger KA, Yamaguchi S, Huerta-Esquivel LL, Schiller PW, Yaksh TL. PMID: 30794333.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    20. Letter to Editor re: "Unique Intradural Inflammatory Mass Containing Precipitated Morphine" by Kim et al. Pain Pract. 2019 04; 19(4):456. Yaksh TL. PMID: 30614650.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery. Scand J Pain. 2019 01 28; 19(1):193-206. Kokubu S, Eddinger KA, Nguyen TM, Huerta-Esquivel LL, Yamaguchi S, Schiller PW, Yaksh TL. PMID: 30367811.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    22. Role of Toll-like receptor 4 signaling in mast cell-mediated migraine pain pathway. Mol Pain. 2019 Jan-Dec; 15:1744806919867842. Ramachandran R, Wang Z, Saavedra C, DiNardo A, Corr M, Powell SB, Yaksh TL. PMID: 31342858.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    23. Botulinum toxin blocks mast cells and prevents rosacea like inflammation. J Dermatol Sci. 2019 Jan; 93(1):58-64. Choi JE, Werbel T, Wang Z, Wu CC, Yaksh TL, Di Nardo A. PMID: 30658871.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    24. Spinal Exparel®-an extended duration of preclinical study needed. Br J Anaesth. 2019 03; 122(3):298-300. Eisenach JC, Yaksh TL. PMID: 30770045.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    25. Development of New Analgesics: An Answer to Opioid Epidemic. Trends Pharmacol Sci. 2018 12; 39(12):1000-1002. Yaksh TL, Hunt MA, Dos Santos GG. PMID: 30454767.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    26. Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats. Pain. 2018 Dec; 159(12):2620-2629. Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. PMID: 30130298.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. Neuraxial TNF and IFN-beta co-modulate persistent allodynia in arthritic mice. Brain Behav Immun. 2019 02; 76:151-158. Woller SA, Ocheltree C, Wong SY, Bui A, Fujita Y, Gonçalves Dos Santos G, Yaksh TL, Corr M. PMID: 30465880.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome. Mol Pain. 2018 Jan-Dec; 14:1744806918815005. Shubayev VI, Strongin AY, Yaksh TL. PMID: 30392459.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    29. Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states. Pain. 2018 Oct; 159(10):1908-1915. Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K. PMID: 29889119.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    30. Transition to chronic pain: opportunities for novel therapeutics. Nat Rev Neurosci. 2018 07; 19(7):383-384. Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH. PMID: 29765159.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    31. Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States. Cell Rep. 2018 05 29; 23(9):2667-2677. Woller SA, Choi SH, An EJ, Low H, Schneider DA, Ramachandran R, Kim J, Bae YS, Sviridov D, Corr M, Yaksh TL, Miller YI. PMID: 29847797.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    32. Complexity of systems and actions underlying neurogenic inflammation. Semin Immunopathol. 2018 05; 40(3):225-228. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Yaksh TL, Di Nardo A. PMID: 29779134.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    33. Rapid continuous 3D printing of customizable peripheral nerve guidance conduits. Mater Today (Kidlington). 2018 Nov; 21(9):951-959. Zhu W, Tringale KR, Woller SA, You S, Johnson S, Shen H, Schimelman J, Whitney M, Steinauer J, Xu W, Yaksh TL, Nguyen QT, Chen S. PMID: 31156331.
      View in: PubMed   Mentions:
    34. A Study and Review of Effects of Botulinum Toxins on Mast Cell Dependent and Independent Pruritus. Toxins (Basel). 2018 03 23; 10(4). Ramachandran R, Marino MJ, Paul S, Wang Z, Mascarenhas NL, Pellett S, Johnson EA, DiNardo A, Yaksh TL. PMID: 29570628.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    35. Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation. Semin Immunopathol. 2018 May; 40(3):237-247. Sorkin LS, Eddinger KA, Woller SA, Yaksh TL. PMID: 29423889.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    36. An overview of pathways encoding nociception. Clin Exp Rheumatol. 2018 Jan-Feb; 36(1):172. Woller SA, Eddinger KA, Corr M, Yaksh TL. PMID: 29461960.
      View in: PubMed   Mentions: 8     Fields:    
    37. Corrigendum to "Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state" [Brain Behav. Immun. 56 (2016) 271-280]. Brain Behav Immun. 2018 03; 69:632. Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Isseroff RR, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL. PMID: 29291934.
      View in: PubMed   Mentions:    Fields:    
    38. Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular. Int J Toxicol. 2018 Jan/Feb; 37(1):4-27. Emami A, Tepper J, Short B, Yaksh TL, Bendele AM, Ramani T, Cisternas AF, Chang JH, Mellon RD. PMID: 29264927.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    39. Target engagement and histopathology of neuraxial resiniferatoxin in dog. Vet Anaesth Analg. 2018 Mar; 45(2):212-226. Hockman TM, Cisternas AF, Jones B, Butt MT, Osborn KG, Steinauer JJ, Malkmus SA, Yaksh TL. PMID: 29361418.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    40. Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics. Anesth Analg. 2017 11; 125(5):1714-1732. Knezevic NN, Yekkirala A, Yaksh TL. PMID: 29049116.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    41. Effects of opioid and nonopioid analgesics on canine wheal formation and cultured human mast cell degranulation. Toxicol Appl Pharmacol. 2018 01 01; 338:54-64. Schmidt-Rondon E, Wang Z, Malkmus SA, Di Nardo A, Hildebrand K, Page L, Yaksh TL. PMID: 29111148.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    42. An overview of pathways encoding nociception. Clin Exp Rheumatol. 2017 Sep-Oct; 35 Suppl 107(5):40-46. Woller SA, Eddinger KA, Corr M, Yaksh TL. PMID: 28967373.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    43. Editor's Highlight: Formulation and Toxicology Evaluation of the Intrathecal AYX1 DNA-Decoy in Sprague Dawley Rats. Toxicol Sci. 2017 09 01; 159(1):76-85. Mamet J, Yeomans DC, Yaksh TL, Manning DC, Harris S. PMID: 28903493.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    44. Modeling Spinal Intrathecal Drug Distribution: The Challenge of Defining and Predicting Cerebrospinal Fluid Dynamics. Anesth Analg. 2017 05; 124(5):1403-1406. Bert RJ, Hayek SM, Yaksh TL. PMID: 28426585.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 10; 18(10):1184-1196. Yaksh TL, Schwarcz R, Snodgrass HR. PMID: 28428091.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    46. Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model. Scand J Pain. 2017 07; 16:1-9. Rijsdijk M, Agalave NM, van Wijck AJM, Kalkman CJ, Ramachandran R, Baharpoor A, Svensson CI, Yaksh TL. PMID: 28850381.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    47. Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor. Sci Rep. 2017 01 03; 7:39662. Flinspach M, Xu Q, Piekarz AD, Fellows R, Hagan R, Gibbs A, Liu Y, Neff RA, Freedman J, Eckert WA, Zhou M, Bonesteel R, Pennington MW, Eddinger KA, Yaksh TL, Hunter M, Swanson RV, Wickenden AD. PMID: 28045073.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    48. The Polyanalgesic Consensus Conference (PACC): Recommendations for Intrathecal Drug Delivery: Guidance for Improving Safety and Mitigating Risks. Neuromodulation. 2017 Feb; 20(2):155-176. Deer TR, Pope JE, Hayek SM, Lamer TJ, Veizi IE, Erdek M, Wallace MS, Grider JS, Levy RM, Prager J, Rosen SM, Saulino M, Yaksh TL, De Andrés JA, Abejon Gonzalez D, Vesper J, Schu S, Simpson B, Mekhail N. PMID: 28042914.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    49. The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines. Neuromodulation. 2017 02; 20(2):96-132. Deer TR, Pope JE, Hayek SM, Bux A, Buchser E, Eldabe S, De Andrés JA, Erdek M, Patin D, Grider JS, Doleys DM, Jacobs MS, Yaksh TL, Poree L, Wallace MS, Prager J, Rauck R, DeLeon O, Diwan S, Falowski SM, Gazelka HM, Kim P, Leong M, Levy RM, McDowell G, McRoberts P, Naidu R, Narouze S, Perruchoud C, Rosen SM, Rosenberg WS, Saulino M, Staats P, Stearns LJ, Willis D, Krames E, Huntoon M, Mekhail N. PMID: 28042904.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    50. Pharmacology, pharmacokinetics, and metabolism of the DNA-decoy AYX1 for the prevention of acute and chronic post-surgical pain. Mol Pain. 2017 01; 13:1744806917703112. Mamet J, Harris S, Klukinov M, Yeomans DC, Donahue RR, Taylor BK, Eddinger K, Yaksh T, Manning DC. PMID: 28394696.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    51. Current and Future Issues in the Development of Spinal Agents for the Management of Pain. Curr Neuropharmacol. 2017; 15(2):232-259. Yaksh TL, Fisher CJ, Hockman TM, Wiese AJ. PMID: 26861470.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    52. Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain. Brain Behav Immun. 2017 Feb; 60:282-292. Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi SK, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev VI. PMID: 27833045.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    53. Ethical Concerns Regarding Human Study. CNS Neurosci Ther. 2016 10; 22(10):866. Eisenach JC, Yaksh TL. PMID: 27577599.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    54. Primary Hydromorphone-Related Intrathecal Catheter Tip Granulomas: Is There a Role for Dose and Concentration? Neuromodulation. 2016 Oct; 19(7):760-769. Veizi IE, Hayek SM, Hanes M, Galica R, Katta S, Yaksh T. PMID: 27505059.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    55. Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation. Anesthesiology. 2016 08; 125(2):378-94. Eddinger KA, Rondon ES, Shubayev VI, Grafe MR, Scadeng M, Hildebrand KR, Page LM, Malkmus SA, Steinauer JJ, Yaksh TL. PMID: 27272672.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    56. Role of myelin auto-antigens in pain: a female connection. Neural Regen Res. 2016 Jun; 11(6):890-1. Shubayev VI, Strongin AY, Yaksh TL. PMID: 27482203.
      View in: PubMed   Mentions:
    57. Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt. Eur J Neurosci. 2016 07; 44(1):1714-22. Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R. PMID: 27108664.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    58. Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid. Cannabis Cannabinoid Res. 2016; 1(1):102-112. Merrick J, Lane B, Sebree T, Yaksh T, O'Neill C, Banks SL. PMID: 28861485.
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    59. Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state. Brain Behav Immun. 2016 08; 56:271-80. Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Isseroff RR, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL. PMID: 27044335.
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    60. Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia. Brain Behav Immun. 2016 Aug; 56:378-89. Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev VI. PMID: 26970355.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    61. The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annu Rev Pharmacol Toxicol. 2016; 56:511-33. Podvin S, Yaksh T, Hook V. PMID: 26738478.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    62. Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models. Scand J Pain. 2016 01; 10:90-102. Rijsdijk M, Svensson CI, Wijck AJ, Kalkman CJ, Yaksh TL. PMID: 28361779.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    63. Current status and future directions of botulinum neurotoxins for targeting pain processing. Toxins (Basel). 2015 Nov 04; 7(11):4519-63. Pellett S, Yaksh TL, Ramachandran R. PMID: 26556371.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    64. The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. Eur J Pain. 2016 07; 20(6):917-25. Park HJ, Sandor K, McQueen J, Woller SA, Svensson CI, Corr M, Yaksh TL. PMID: 26517300.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    65. The effects of intraplantar and intrathecal botulinum toxin type B on tactile allodynia in mono and polyneuropathy in the mouse. Anesth Analg. 2015 Jul; 121(1):229-238. Park HJ, Marino MJ, Rondon ES, Xu Q, Yaksh TL. PMID: 26039418.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    66. The search for novel analgesics: targets and mechanisms. F1000Prime Rep. 2015; 7:56. Yaksh TL, Woller SA, Ramachandran R, Sorkin LS. PMID: 26097729.
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    67. Botulinum toxin in migraine: Role of transport in trigemino-somatic and trigemino-vascular afferents. Neurobiol Dis. 2015 Jul; 79:111-22. Ramachandran R, Lam C, Yaksh TL. PMID: 25958249.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    68. Differences in cisplatin-induced mechanical allodynia in male and female mice. Eur J Pain. 2015 Nov; 19(10):1476-85. Woller SA, Corr M, Yaksh TL. PMID: 25716290.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    69. High cerebrospinal fluid levels of interleukin-10 attained by AAV in dogs. Gene Ther. 2015 Feb; 22(2):202-8. Pleticha J, Malkmus SA, Heilmann LF, Veesart SL, Rezek R, Xu Q, Yaksh TL, Beutler AS. PMID: 25354684.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    70. Therapeutic use of botulinum toxin in migraine: mechanisms of action. Br J Pharmacol. 2014 Sep; 171(18):4177-92. Ramachandran R, Yaksh TL. PMID: 24819339.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    71. Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity. Eur J Pain. 2015 Feb; 19(2):260-70. Bas DB, Abdelmoaty S, Sandor K, Codeluppi S, Fitzsimmons B, Steinauer J, Hua XY, Yaksh TL, Svensson CI. PMID: 24942612.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    72. The effects of glucocorticoids on neuropathic pain: a review with emphasis on intrathecal methylprednisolone acetate delivery. Anesth Analg. 2014 May; 118(5):1097-112. Rijsdijk M, van Wijck AJ, Kalkman CJ, Yaksh TL. PMID: 24781577.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    73. TRPV1 expression regulation… A further step in defining its biology: commentary for K. Zavala et al. "The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons" [Neurosci. Lett. (2014) doi:10.1016/j.neulet.2014.01.021]. Neurosci Lett. 2014 Aug 22; 578:209-10. Yaksh TL. PMID: 24769421.
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    74. Preclinical toxicity screening of intrathecal oxytocin in rats and dogs. Anesthesiology. 2014 Apr; 120(4):951-61. Yaksh TL, Hobo S, Peters C, Osborn KG, Richter PJ, Rossi SS, Grafe MR, Eisenach JC. PMID: 24492326.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    75. Supraspinal characterization of the thermal grill illusion with fMRI. Mol Pain. 2014 Mar 11; 10:18. Leung A, Shukla S, Li E, Duann JR, Yaksh T. PMID: 24612493.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    76. Spinal cord ischemia/injury. Curr Pharm Des. 2014; 20(36):5738-43. Ishikawa T, Suzuki H, Ishikawa K, Yasuda S, Matsui T, Yamamoto M, Kakeda T, Yamamoto S, Owada Y, Yaksh TL. PMID: 24502574.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    77. Botulinum toxin B in the sensory afferent: transmitter release, spinal activation, and pain behavior. Pain. 2014 Apr; 155(4):674-684. Marino MJ, Terashima T, Steinauer JJ, Eddinger KA, Yaksh TL, Xu Q. PMID: 24333775.
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    78. Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. J Neuroinflammation. 2013 Dec 09; 10:148. Stokes JA, Cheung J, Eddinger K, Corr M, Yaksh TL. PMID: 24321498.
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    79. Intrathecal substance P-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation. Anesthesiology. 2013 Nov; 119(5):1163-77. Wiese AJ, Rathbun M, Butt MT, Malkmus SA, Richter PJ, Osborn KG, Xu Q, Veesart SL, Steinauer JJ, Higgins D, Lappi DA, Russell B, Yaksh TL. PMID: 24051388.
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    80. Toll-like receptor signaling regulates cisplatin-induced mechanical allodynia in mice. Cancer Chemother Pharmacol. 2014 Jan; 73(1):25-34. Park HJ, Stokes JA, Corr M, Yaksh TL. PMID: 24162377.
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    81. Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury. Pain. 2014 Feb; 155(2):322-333. Mamet J, Klukinov M, Yaksh TL, Malkmus SA, Williams S, Harris S, Manning DC, Taylor BK, Donahue RR, Porreca F, Xie JY, Oyarzo J, Brennan TJ, Subieta A, Schmidt WK, Yeomans DC. PMID: 24145208.
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    82. Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. J Pharmacol Exp Ther. 2013 Nov; 347(2):258-64. Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q. PMID: 23978562.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    83. Neuroscience: Bacteria get on your nerves. Nature. 2013 Sep 05; 501(7465):43-4. Nizet V, Yaksh T. PMID: 23965630.
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    84. Effects of general anesthetics on substance P release and c-Fos expression in the spinal dorsal horn. Anesthesiology. 2013 Aug; 119(2):433-42. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Takasusuki T, Yamaguchi S, Hamaguchi S, Yaksh TL. PMID: 23708866; PMCID: PMC3788114.
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    85. Evaluation of spinal toxicity and long-term spinal reflex function after intrathecal levobupivaciane in the neonatal rat. Anesthesiology. 2013 Jul; 119(1):142-55. Hamurtekin E, Fitzsimmons BL, Shubayev VI, Grafe MR, Deumens R, Yaksh TL, Walker SM. PMID: 23514721.
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    86. Intrathecal P/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression. Neuropharmacology. 2013 Dec; 75:1-8. Terashima T, Xu Q, Yamaguchi S, Yaksh TL. PMID: 23810829.
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    87. Intrathecal neurosteroids and a neurosteroid antagonist: effects on inflammation-evoked thermal hyperalgesia and tactile allodynia. Neurosci Lett. 2013 Aug 26; 548:27-32. Svensson E, Persson J, Fitzsimmons B, Yaksh TL. PMID: 23707652.
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    88. Role of meningeal mast cells in intrathecal morphine-evoked granuloma formation. Anesthesiology. 2013 Mar; 118(3):664-78. Yaksh TL, Allen JW, Veesart SL, Horais KA, Malkmus SA, Scadeng M, Steinauer JJ, Rossi SS. PMID: 23426209.
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    89. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. FASEB J. 2013 May; 27(5):1939-49. Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA. PMID: 23382512.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    90. Spinal toll-like receptor signaling and nociceptive processing: regulatory balance between TIRAP and TRIF cascades mediated by TNF and IFNβ. Pain. 2013 May; 154(5):733-742. Stokes JA, Corr M, Yaksh TL. PMID: 23489833.
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    91. Spinal astrocytes produce and secrete dynorphin neuropeptides. Neuropeptides. 2013 Apr; 47(2):109-15. Wahlert A, Funkelstein L, Fitzsimmons B, Yaksh T, Hook V. PMID: 23290538.
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    92. Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. Anesth Analg. 2013 Jan; 116(1):224-31. Park HJ, Stokes JA, Pirie E, Skahen J, Shtaerman Y, Yaksh TL. PMID: 23223118.
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    93. Alfentanil: correlations between absence of effect upon subcutaneous mast cells and absence of granuloma formation after intrathecal infusion in the dog. Neuromodulation. 2013 Sep-Oct; 16(5):459-66; discussion 466. Yaksh TL, Steinauer JJ, Veesart SL, Malkmus SA. PMID: 23170763.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    94. Development and validation of an automated system for detection and assessment of scratching in the rodent. J Neurosci Methods. 2012 Oct 15; 211(1):1-10. Marino M, Huang P, Malkmus S, Robertshaw E, Mac EA, Shatterman Y, Yaksh TL. PMID: 22971351.
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    95. Polyanalgesic Consensus Conference--2012: recommendations to reduce morbidity and mortality in intrathecal drug delivery in the treatment of chronic pain. Neuromodulation. 2012 Sep-Oct; 15(5):467-82; discussion 482. Deer TR, Levy R, Prager J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, Kumar K, Leong M, Liem L, McDowell GC, Panchal S, Rauck R, Saulino M, Sitzman BT, Staats P, Stanton-Hicks M, Stearns L, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. PMID: 22849581.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    96. Characteristics of distribution of morphine and metabolites in cerebrospinal fluid and plasma with chronic intrathecal morphine infusion in humans. Anesth Analg. 2012 Oct; 115(4):797-804. Wallace M, Yaksh TL. PMID: 22822192.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    97. Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12728-33. Lampa J, Westman M, Kadetoff D, Agréus AN, Le Maître E, Gillis-Haegerstrand C, Andersson M, Khademi M, Corr M, Christianson CA, Delaney A, Yaksh TL, Kosek E, Svensson CI. PMID: 22802629.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCTClinical Trials
    98. Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data. Anesth Analg. 2012 Sep; 115(3):638-62. Walker SM, Yaksh TL. PMID: 22798528.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    99. Polyanalgesic Consensus Conference 2012: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation. 2012 Sep-Oct; 15(5):436-64; discussion 464-6. Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, Kumar K, Leong M, Liem L, McDowell GC, Panchal S, Rauck R, Saulino M, Sitzman BT, Staats P, Stanton-Hicks M, Stearns L, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. PMID: 22748024.
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    100. Pharmacokinetic analysis of ziconotide (SNX-111), an intrathecal N-type calcium channel blocking analgesic, delivered by bolus and infusion in the dog. Neuromodulation. 2012 Nov-Dec; 15(6):508-19; discussion 519. Yaksh TL, de Kater A, Dean R, Best BM, Miljanich GP. PMID: 22748108.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    101. Perineural local anesthetic and adjuvant action: the meaning of an ex vivo data set for efficacy and safety. Reg Anesth Pain Med. 2012 Jul-Aug; 37(4):366-8. Yaksh TL, Ilfeld BM, Wiese AJ. PMID: 22660488.
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    102. Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial. Ann Intern Med. 2012 Apr 17; 156(8):551-9. Cohen SP, White RL, Kurihara C, Larkin TM, Chang A, Griffith SR, Gilligan C, Larkin R, Morlando B, Pasquina PF, Yaksh TL, Nguyen C. PMID: 22508732.
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    103. Polyanalgesic Consensus Conference--2012: consensus on diagnosis, detection, and treatment of catheter-tip granulomas (inflammatory masses). Neuromodulation. 2012 Sep-Oct; 15(5):483-95; discussion 496. Deer TR, Prager J, Levy R, Rathmell J, Buchser E, Burton A, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs MS, Kim P, Kumar K, Leong M, Liem L, McDowell GC, Panchal S, Rauck R, Saulino M, Sitzman BT, Staats P, Stanton-Hicks M, Stearns L, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. PMID: 22494332.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    104. Polyanalgesic Consensus Conference--2012: recommendations on trialing for intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation. 2012 Sep-Oct; 15(5):420-35; discussion 435. Deer TR, Prager J, Levy R, Burton A, Buchser E, Caraway D, Cousins M, De Andrés J, Diwan S, Erdek M, Grigsby E, Huntoon M, Jacobs M, Kim P, Kumar K, Leong M, Liem L, McDowell G, Panchal SJ, Rauck R, Saulino M, Staats P, Stanton-Hicks M, Stearns L, Sitzman BT, Wallace M, Willis KD, Witt W, Yaksh T, Mekhail N. PMID: 22494357.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    105. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6721-6. Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL. PMID: 22493235.
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    106. Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity. Anesth Analg. 2012 Aug; 115(2):450-60. Walker SM, Grafe M, Yaksh TL. PMID: 22467896.
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    107. Safety assessment and pharmacokinetics of intrathecal methylprednisolone acetate in dogs. Anesthesiology. 2012 Jan; 116(1):170-81. Rijsdijk M, van Wijck AJ, Kalkman CJ, Meulenhoff PC, Grafe MR, Steinauer J, Yaksh TL. PMID: 22139590.
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    108. K/BxN serum transfer arthritis as a model of inflammatory joint pain. Methods Mol Biol. 2012; 851:249-60. Christianson CA, Corr M, Yaksh TL, Svensson CI. PMID: 22351097.
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    109. Effects of long term polyarthritis and subsequent NSAID treatment on activity with disassociation of tactile allodynia in the mouse. Neurocomputing. 2012 May 01; 84:47-52. Suhail MS, Christianson C, Koehrn F, Malkmus SA, Mitchell W, Corr M, Yaksh TL. PMID: 22547902.
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    110. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain. 2011 Dec; 152(12):2881-2891. Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, Yaksh TL. PMID: 22019135.
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    111. Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism. Neuroscience. 2012 Jan 03; 200:199-210. Christianson CA, Fitzsimmons BL, Shim JH, Agrawal A, Cohen SM, Hua XY, Yaksh TL. PMID: 22056600.
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    112. The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats. J Anesth. 2011 Dec; 25(6):884-91. Kim HJ, Seol TK, Lee HJ, Yaksh TL, Jun JH. PMID: 21983967.
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    113. Transient tactile allodynia following intrathecal puncture in mouse: contributions of Toll-like receptor signaling. Neurosci Lett. 2011 Oct 31; 504(3):215-8. Stokes JA, Corr M, Yaksh TL. PMID: 21964382.
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    114. Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia. Neuroscience. 2011 Oct 27; 194:160-9. Fuchigami T, Kakinohana O, Hefferan MP, Lukacova N, Marsala S, Platoshyn O, Sugahara K, Yaksh TL, Marsala M. PMID: 21871540.
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    115. A brief comparison of the pathophysiology of inflammatory versus neuropathic pain. Curr Opin Anaesthesiol. 2011 Aug; 24(4):400-7. Xu Q, Yaksh TL. PMID: 21659872.
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    116. Care to wrestle with a Brazilian armed spider? Pain. 2011 Oct; 152(10):2193-2195. Yaksh TL. PMID: 21782344.
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    117. Regulation of spinal substance p release by intrathecal calcium channel blockade. Anesthesiology. 2011 Jul; 115(1):153-64. Takasusuki T, Yaksh TL. PMID: 21577088.
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    118. Spinal toxins can have persistent adverse effects. Pain Med. 2011 Jul; 12(7):991-2. Yaksh TL. PMID: 21752177.
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    119. Spinal botulinum neurotoxin B: effects on afferent transmitter release and nociceptive processing. PLoS One. 2011 Apr 29; 6(4):e19126. Huang PP, Khan I, Suhail MS, Malkmus S, Yaksh TL. PMID: 21559464.
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    120. The effects of intrathecal and systemic gabapentin on spinal substance P release. Anesth Analg. 2011 Apr; 112(4):971-6. Takasusuki T, Yaksh TL. PMID: 21385982.
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    121. Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. J Neurosci. 2011 Feb 09; 31(6):2113-24. Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL. PMID: 21307248.
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    122. Suppression of stretch reflex activity after spinal or systemic treatment with AMPA receptor antagonist NGX424 in rats with developed baclofen tolerance. Br J Pharmacol. 2010 Nov; 161(5):976-85. Oshiro M, Hefferan MP, Kakinohana O, Lukacova N, Sugahara K, Yaksh TL, Marsala M. PMID: 20977450.
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    123. Recommendations for the use of preclinical models in the study and treatment of osteoarthritis. Osteoarthritis Cartilage. 2010 Oct; 18 Suppl 3:S10-6. Poole R, Blake S, Buschmann M, Goldring S, Laverty S, Lockwood S, Matyas J, McDougall J, Pritzker K, Rudolphi K, van den Berg W, Yaksh T. PMID: 20864015.
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    124. Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis. Pain. 2010 Nov; 151(2):394-403. Christianson CA, Corr M, Firestein GS, Mobargha A, Yaksh TL, Svensson CI. PMID: 20739123.
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    125. Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. Br J Pharmacol. 2010 Aug; 160(7):1754-64. Saito O, Svensson CI, Buczynski MW, Wegner K, Hua XY, Codeluppi S, Schaloske RH, Deems RA, Dennis EA, Yaksh TL. PMID: 20649577.
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    126. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res. 2010 Sep 17; 1352:83-93. Peters CM, Hayashida K, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC. PMID: 20637741.
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    127. Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase. Anesth Analg. 2010 Aug; 111(2):554-60. Matsui T, Svensson CI, Hirata Y, Mizobata K, Hua XY, Yaksh TL. PMID: 20610553.
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    128. Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome. Anesthesiology. 2010 Jul; 113(1):147-59. Walker SM, Westin BD, Deumens R, Grafe M, Yaksh TL. PMID: 20526188.
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    129. Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat. Anesthesiology. 2010 Jul; 113(1):183-99. Westin BD, Walker SM, Deumens R, Grafe M, Yaksh TL. PMID: 20526189.
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    130. Assessment of canine sensory function by using sine-wave electrical stimuli paradigm. Physiol Behav. 2010 Oct 05; 101(3):327-30. Watabiki T, Nagakura Y, Wegner K, Kakimoto S, Tozier NA, Malkmus SA, Yaksh TL. PMID: 20570687.
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    131. Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. J Neurochem. 2010 Aug; 114(4):981-93. Buczynski MW, Svensson CI, Dumlao DS, Fitzsimmons BL, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA. PMID: 20492349.
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    132. Role of spinal cyclooxygenase in human postoperative and chronic pain. Anesthesiology. 2010 May; 112(5):1225-33. Eisenach JC, Curry R, Rauck R, Pan P, Yaksh TL. PMID: 20395820.
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    133. Effects of intrathecal ketorolac on human experimental pain. Anesthesiology. 2010 May; 112(5):1216-24. Eisenach JC, Curry R, Tong C, Houle TT, Yaksh TL. PMID: 20395821.
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    134. Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs. Cell Transplant. 2010; 19(9):1103-22. Usvald D, Vodicka P, Hlucilova J, Prochazka R, Motlik J, Kuchorova K, Johe K, Marsala S, Scadeng M, Kakinohana O, Navarro R, Santa M, Hefferan MP, Yaksh TL, Marsala M. PMID: 20412634.
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    135. Consent contraindicated? Science. 2010 Apr 02; 328(5974):45; author reply 45. Yaksh TL, Eisenach JC, Shafer SL. PMID: 20360092.
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    136. The need for a journal policy on intrathecal, epidural, and perineural administration of non-approved drugs. Pain. 2010 Jun; 149(3):417-419. Eisenach JC, Shafer SL, Yaksh T. PMID: 20227830.
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    137. Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression. Neuroreport. 2010 Mar 10; 21(4):313-7. Fitzsimmons BL, Zattoni M, Svensson CI, Steinauer J, Hua XY, Yaksh TL. PMID: 20134354.
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    138. Correlation between myoclonus and the 3-glucuronide metabolites in patients treated with morphine or hydromorphone: a pilot study. J Opioid Manag. 2010 Mar-Apr; 6(2):87-94. McCann S, Yaksh TL, von Gunten CF. PMID: 20481173.
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    139. [Vacuoles: a hollow threat?]. Can J Anaesth. 2010 Mar; 57(3):195-200. Yaksh TL. PMID: 20054677.
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    140. Preclinical research on persistent postsurgical pain: what we don't know, but should start studying. Anesthesiology. 2010 Mar; 112(3):511-3. Scholz J, Yaksh TL. PMID: 20124975.
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    141. Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. Neurosci Lett. 2010 Feb 05; 470(1):6-9. Park P, Schachter S, Yaksh T. PMID: 20026382.
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    142. Behavioral models of pain states evoked by physical injury to the peripheral nerve. Neurotherapeutics. 2009 Oct; 6(4):609-19. Sorkin LS, Yaksh TL. PMID: 19789066.
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    143. New caudal additives in children: benefit vs. risk? Acta Anaesthesiol Scand. 2009 Sep; 53(8):1097-8; author reply 1098-9. Walker SM, Yaksh TL. PMID: 19694618.
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    144. Randomized, double-blind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica. Anesthesiology. 2009 May; 110(5):1116-26. Cohen SP, Bogduk N, Dragovich A, Buckenmaier CC, Griffith S, Kurihara C, Raymond J, Richter PJ, Williams N, Yaksh TL. PMID: 19387178.
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    145. The end of postoperative pain--a fast-approaching possibility? And, if so, will we be ready? Reg Anesth Pain Med. 2009 Mar-Apr; 34(2):85-7. Ilfeld BM, Yaksh TL. PMID: 19282704.
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    146. Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology. 2009 Apr; 136(4):1339-48, e1-2. Bradesi S, Svensson CI, Steinauer J, Pothoulakis C, Yaksh TL, Mayer EA. PMID: 19249394.
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    147. Spinal antinociceptive action of loperamide is mediated by opioid receptors in the formalin test in rats. Neurosci Lett. 2008 Dec 31; 448(3):260-2. Ray SB, Yaksh TL. PMID: 18973791.
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    148. Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain. Pharmacol Biochem Behav. 2008 Oct; 90(4):664-75. Svensson CI, Medicherla S, Malkmus S, Jiang Y, Ma JY, Kerr I, Brainin-Mattos J, Powell HC, Luo ZD, Chakravarty S, Dugar S, Higgins LS, Protter AA, Yaksh TL. PMID: 18584857.
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    149. Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine. Br J Pharmacol. 2008 Dec; 155(7):1117-26. Nazarian A, Christianson CA, Hua XY, Yaksh TL. PMID: 18846040.
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    150. Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12599-604. Ilieva HS, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW. PMID: 18719118.
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    151. The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy. Pain. 2008 Oct 31; 139(3):569-577. Nagakura Y, Jones TL, Malkmus SA, Sorkin L, Yaksh TL. PMID: 18692315.
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    152. Acetaminophen prevents hyperalgesia in central pain cascade. Neurosci Lett. 2008 Sep 05; 442(1):50-3. Crawley B, Saito O, Malkmus S, Fitzsimmons B, Hua XY, Yaksh TL. PMID: 18601979.
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    153. Toxicology profile of N-methyl-D-aspartate antagonists delivered by intrathecal infusion in the canine model. Anesthesiology. 2008 May; 108(5):938-49. Yaksh TL, Tozier N, Horais KA, Malkmus S, Rathbun M, Lafranco L, Eisenach J. PMID: 18431131.
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    154. The effect of acupuncture duration on analgesia and peripheral sensory thresholds. BMC Complement Altern Med. 2008 May 01; 8:18. Leung AY, Kim SJ, Schulteis G, Yaksh T. PMID: 18452622.
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    155. Inhibition of spinal cytosolic phospholipase A(2) expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia. Neuroscience. 2008 Jun 26; 154(3):1077-87. Kim DH, Fitzsimmons B, Hefferan MP, Svensson CI, Wancewicz E, Monia BP, Hung G, Butler M, Marsala M, Hua XY, Yaksh TL. PMID: 18511207.
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    156. Spinal N-methyl-D-aspartate receptors and nociception-evoked release of primary afferent substance P. Neuroscience. 2008 Mar 03; 152(1):119-27. Nazarian A, Gu G, Gracias NG, Wilkinson K, Hua XY, Vasko MR, Yaksh TL. PMID: 18222611.
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    157. Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. Neuropharmacology. 2008 Feb; 54(2):269-79. Khan IM, Wart CV, Singletary EA, Stanislaus S, Deerinck T, Yaksh TL, Printz MP. PMID: 18037142.
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    158. Spinal astrocyte glutamate receptor 1 overexpression after ischemic insult facilitates behavioral signs of spasticity and rigidity. J Neurosci. 2007 Oct 17; 27(42):11179-91. Hefferan MP, Kucharova K, Kinjo K, Kakinohana O, Sekerkova G, Nakamura S, Fuchigami T, Tomori Z, Yaksh TL, Kurtz N, Marsala M. PMID: 17942713.
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    159. Development of a canine nociceptive thermal escape model. J Neurosci Methods. 2008 Feb 15; 168(1):88-97. Wegner K, Horais KA, Tozier NA, Rathbun ML, Shtaerman Y, Yaksh TL. PMID: 18054083.
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    160. Neonates have a spinal alpha receptor too, as do adults. Br J Pharmacol. 2007 Aug; 151(8):1139-40. Yaksh TL. PMID: 17641678.
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    161. Mandating two-year regional anesthesia fellowships: fanning the academic flame or extinguishing it? Reg Anesth Pain Med. 2007 Jul-Aug; 32(4):275-9. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Ilfeld BM, Yaksh TL, Neal JM. PMID: 17720109; PMCID: PMC2048748.
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    162. Determination of current threshold for paw withdrawal with sine-wave electrical stimulation in rats: effect of drugs and alteration in acute inflammation. Pain. 2008 Feb; 134(3):293-301. Nagakura Y, Malkmus S, Yaksh TL. PMID: 17583428.
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    163. An assessment of the antinociceptive efficacy of intrathecal and epidural contulakin-G in rats and dogs. Anesth Analg. 2007 Jun; 104(6):1505-13, table of contents. Allen JW, Hofer K, McCumber D, Wagstaff JD, Layer RT, McCabe RT, Yaksh TL. PMID: 17513650.
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    164. The pharmacokinetics of the conopeptide contulakin-G (CGX-1160) after intrathecal administration: an analysis of data from studies in beagles. Anesth Analg. 2007 Jun; 104(6):1514-20, table of contents. Kern SE, Allen J, Wagstaff J, Shafer SL, Yaksh T. PMID: 17513651.
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    165. Inhibition of spinal constitutive NOS-2 by 1400W attenuates tissue injury and inflammation-induced hyperalgesia and spinal p38 activation. Eur J Neurosci. 2007 May; 25(10):2964-72. Tang Q, Svensson CI, Fitzsimmons B, Webb M, Yaksh TL, Hua XY. PMID: 17561811.
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    166. Descending serotonergic facilitation of spinal ERK activation and pain behavior. FEBS Lett. 2006 Dec 11; 580(28-29):6629-34. Svensson CI, Tran TK, Fitzsimmons B, Yaksh TL, Hua XY. PMID: 17113581.
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    167. The electrophysiology of de qi sensations. J Altern Complement Med. 2006 Oct; 12(8):743-50. Leung AY, Park J, Schulteis G, Duann JR, Yaksh T. PMID: 17034280.
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    168. Time course and role of morphine dose and concentration in intrathecal granuloma formation in dogs: a combined magnetic resonance imaging and histopathology investigation. Anesthesiology. 2006 Sep; 105(3):581-9. Allen JW, Horais KA, Tozier NA, Wegner K, Corbeil JA, Mattrey RF, Rossi SS, Yaksh TL. PMID: 16931993.
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    169. Opiate pharmacology of intrathecal granulomas. Anesthesiology. 2006 Sep; 105(3):590-8. Allen JW, Horais KA, Tozier NA, Yaksh TL. PMID: 16931994.
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    170. Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study. Neuroscience. 2006 Sep 01; 141(3):1569-83. Kakinohana O, Hefferan MP, Nakamura S, Kakinohana M, Galik J, Tomori Z, Marsala J, Yaksh TL, Marsala M. PMID: 16797137.
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    171. Covariance among age, spinal p38 MAP kinase activation and allodynia. J Pain. 2006 May; 7(5):337-45. Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin LS. PMID: 16632323.
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    172. Characterization of interference with 6 commercial delta9-tetrahydrocannabinol immunoassays by efavirenz (glucuronide) in urine. Clin Chem. 2006 May; 52(5):896-7. Rossi S, Yaksh T, Bentley H, van den Brande G, Grant I, Ellis R. PMID: 16638958.
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    173. Cancer-related bone pain is attenuated by a systemically available delta-opioid receptor agonist. Pain. 2006 May; 122(1-2):174-81. Brainin-Mattos J, Smith ND, Malkmus S, Rew Y, Goodman M, Taulane J, Yaksh TL. PMID: 16545911.
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    174. Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs. Toxicol Sci. 2006 May; 91(1):286-98. Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL. PMID: 16500924.
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    175. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur J Neurosci. 2006 Feb; 23(3):627-36. Shi TJ, Hua XY, Lu X, Malkmus S, Kinney J, Holmberg K, Wirz S, Ceccatelli S, Yaksh T, Bartfai T, Hökfelt T. PMID: 16487144.
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    176. Calcium channels as therapeutic targets in neuropathic pain. J Pain. 2006 Jan; 7(1 Suppl 1):S13-30. Yaksh TL. PMID: 16426997.
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    177. Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia. Eur J Neurosci. 2005 Nov; 22(10):2431-40. Hua XY, Svensson CI, Matsui T, Fitzsimmons B, Yaksh TL, Webb M. PMID: 16307586.
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    178. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. J Pharmacol Exp Ther. 2006 Jan; 316(1):466-75. Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA. PMID: 16203828.
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    179. Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. Neuropeptides. 2005 Oct; 39(5):485-94. Svensson CI, Hua XY, Powell HC, Lai J, Porreca F, Yaksh TL. PMID: 16176831.
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    180. Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain. 2005 Nov; 118(1-2):112-24. Nielsen CK, Lewis RJ, Alewood D, Drinkwater R, Palant E, Patterson M, Yaksh TL, McCumber D, Smith MT. PMID: 16154696.
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    181. Unexpected pain in a dog: aberration or worthy of a citation? Agree to disagree. Lab Anim (NY). 2005 Sep; 34(8):19. Torchia M, Yaksh T. PMID: 16136070.
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    182. The effect of Ting point (tendinomuscular meridians) electroacupuncture on thermal pain: a model for studying the neuronal mechanism of acupuncture analgesia. J Altern Complement Med. 2005 Aug; 11(4):653-61. Leung A, Khadivi B, Duann JR, Cho ZH, Yaksh T. PMID: 16131289.
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    183. Qualitative and quantitative characterization of the thermal grill. Pain. 2005 Jul; 116(1-2):26-32. Leung AY, Wallace MS, Schulteis G, Yaksh TL. PMID: 15935558.
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    184. Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence. J Pharmacol Exp Ther. 2005 Sep; 314(3):1362-9. Gu G, Kondo I, Hua XY, Yaksh TL. PMID: 15908510.
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    185. Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. J Neurosci. 2005 Apr 06; 25(14):3651-60. Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL. PMID: 15814796.
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    186. Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. Br J Pharmacol. 2005 Apr; 144(7):940-52. Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. PMID: 15685208.
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    187. Mechanisms of antinociception of spinal galanin: how does galanin inhibit spinal sensitization? Neuropeptides. 2005 Jun; 39(3):211-6. Hua XY, Salgado KF, Gu G, Fitzsimmons B, Kondo I, Bartfai T, Yaksh TL. PMID: 15944014.
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    188. Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. J Neurochem. 2005 Mar; 92(6):1508-20. Svensson CI, Fitzsimmons B, Azizi S, Powell HC, Hua XY, Yaksh TL. PMID: 15748168.
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    189. Increased hyperalgesia after tissue injury and faster recovery of allodynia after nerve injury in the GalR1 knockout mice. Neuropeptides. 2005 Jun; 39(3):217-21. Malkmus S, Lu X, Bartfai T, Yaksh TL, Hua XY. PMID: 15944015.
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    190. Spinal phospholipase A2 in inflammatory hyperalgesia: role of the small, secretory phospholipase A2. Neuroscience. 2005; 133(2):543-53. Svensson CI, Lucas KK, Hua XY, Powell HC, Dennis EA, Yaksh TL. PMID: 15885922.
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    191. Spinal distribution and metabolism of 2'-O-(2-methoxyethyl)-modified oligonucleotides after intrathecal administration in rats. Neuroscience. 2005; 131(3):705-15. Butler M, Hayes CS, Chappell A, Murray SF, Yaksh TL, Hua XY. PMID: 15730875.
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    192. Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia. Eur J Neurosci. 2004 Nov; 20(9):2401-14. Marsala M, Kakinohana O, Yaksh TL, Tomori Z, Marsala S, Cizkova D. PMID: 15525281.
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    193. Ablation of primary afferent terminals reduces nicotinic receptor expression and the nociceptive responses to nicotinic agonists in the spinal cord. J Neurocytol. 2004 Sep; 33(5):543-56. Khan IM, Wennerholm M, Singletary E, Polston K, Zhang L, Deerinck T, Yaksh TL, Taylor P. PMID: 15906161.
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    194. A preclinical post laminectomy rat model mimics the human post laminectomy syndrome. J Neurosci Methods. 2004 Aug 30; 137(2):283-9. Massie JB, Huang B, Malkmus S, Yaksh TL, Kim CW, Garfin SR, Akeson WH. PMID: 15262072.
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    195. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10470-5. Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J. PMID: 15240875.
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    196. Intrathecal protease-activated receptor stimulation produces thermal hyperalgesia through spinal cyclooxygenase activity. J Pharmacol Exp Ther. 2004 Oct; 311(1):356-63. Koetzner L, Gregory JA, Yaksh TL. PMID: 15175421.
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    197. Preclinical insights into the implementation of intrathecal midazolam: a cautionary tale. Anesth Analg. 2004 Jun; 98(6):1509-1511. Yaksh TL, Allen JW. PMID: 15155298.
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    198. The use of intrathecal midazolam in humans: a case study of process. Anesth Analg. 2004 Jun; 98(6):1536-1545. Yaksh TL, Allen JW. PMID: 15155302.
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    199. Intrathecal ketorolac in dogs and rats. Toxicol Sci. 2004 Aug; 80(2):322-34. Yaksh TL, Horais KA, Tozier N, Rathbun M, Richter P, Rossi S, Grafe M, Tong C, Meschter C, Cline JM, Eisenach J. PMID: 15141096.
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    200. Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia. J Neurosci. 2004 Mar 17; 24(11):2727-32. Ghilardi JR, Svensson CI, Rogers SD, Yaksh TL, Mantyh PW. PMID: 15028765.
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    201. Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. J Neurosci. 2004 Feb 11; 24(6):1451-8. Koetzner L, Hua XY, Lai J, Porreca F, Yaksh T. PMID: 14960618.
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    202. Intrathecal but not intravenous opioids release adenosine from the spinal cord. J Pain. 2004 Feb; 5(1):64-8. Eisenach JC, Hood DD, Curry R, Sawynok J, Yaksh TL, Li X. PMID: 14975380.
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    203. Assessment of acute thermal nociception in laboratory animals. Methods Mol Med. 2004; 99:11-23. Allen JW, Yaksh TL. PMID: 15131325.
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    204. Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Exp Neurol. 2004 Jan; 185(1):160-8. Schäfers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C. PMID: 14697327.
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    205. Tissue injury models of persistent nociception in rats. Methods Mol Med. 2004; 99:25-34. Allen JW, Yaksh TL. PMID: 15131326.
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    206. Intrathecal catheterization and drug delivery in the rat. Methods Mol Med. 2004; 99:109-21. Malkmus SA, Yaksh TL. PMID: 15131333.
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    207. Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways. J Comp Neurol. 2003 Dec 01; 467(1):44-59. Khan I, Osaka H, Stanislaus S, Calvo RM, Deerinck T, Yaksh TL, Taylor P. PMID: 14574679.
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    208. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther. 2004 Feb; 308(2):574-82. Hua XY, Hayes CS, Hofer A, Fitzsimmons B, Kilk K, Langel U, Bartfai T, Yaksh TL. PMID: 14610237.
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    209. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003 Sep; 86(6):1534-44. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. PMID: 12950462.
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    210. Chronically infused intrathecal morphine in dogs. Anesthesiology. 2003 Jul; 99(1):174-87. Yaksh TL, Horais KA, Tozier NA, Allen JW, Rathbun M, Rossi SS, Sommer C, Meschter C, Richter PJ, Hildebrand KR. PMID: 12826858.
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    211. Preclinical work leading to the development of spinal analgesia. Anesthesiology. 2003 Jul; 99(1):224-5. Yaksh TL. PMID: 12826864.
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    212. A double-lumen intrathecal catheter for studies of modulation of spinal opiate tolerance. J Neurosci Methods. 2003 Jun 30; 126(2):165-73. Hayes CS, Mulkmus SA, Cizkova D, Yaksh TL, Hua XY. PMID: 12814841.
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    213. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosci. 2003 Jun 15; 23(12):5031-40. South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage FH, Yaksh TL, Woolf CJ, Heinemann SF, Inturrisi CE. PMID: 12832526.
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    214. Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia. Neuroreport. 2003 Jun 11; 14(8):1153-7. Svensson CI, Hua XY, Protter AA, Powell HC, Yaksh TL. PMID: 12821799.
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    215. Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci. 2003 Apr 01; 23(7):3028-38. Schäfers M, Lee DH, Brors D, Yaksh TL, Sorkin LS. PMID: 12684490.
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    216. Neuraxial morphine may trigger transient motor dysfunction after a noninjurious interval of spinal cord ischemia: a clinical and experimental study. Anesthesiology. 2003 Apr; 98(4):862-70. Kakinohana M, Marsala M, Carter C, Davison JK, Yaksh TL. PMID: 12657847.
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    217. Rapid quantification of the non-competitive NMDA antagonist MK-801 in canine cerebrospinal fluid and plasma by capillary gas chromatography-nitrogen phosphorus detection. J Pharm Biomed Anal. 2003 Feb 26; 31(2):243-50. Rossi S, Yaksh T. PMID: 12609663.
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    218. Epidural ketamine in healthy children--what's the point? Anesth Analg. 2003 Feb; 96(2):626; author reply 626-7. Eisenach JC, Yaksh TL. PMID: 12538224.
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    219. Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog. J Pharmacol Exp Ther. 2003 Feb; 304(2):827-32. Svensson CI, Rew Y, Malkmus S, Schiller PW, Taulane JP, Goodman M, Yaksh TL. PMID: 12538839.
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    220. Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats. Br J Pharmacol. 2003 Feb; 138(4):689-97. Ibuki T, Marsala M, Masuyama T, Yaksh TL. PMID: 12598423.
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    221. Effects of chronic intrathecal infusion of a partial differential opioid agonist in dogs. Toxicol Sci. 2003 Feb; 71(2):263-75. Horais K, Hruby V, Rossi S, Cizkova D, Meschter C, Dorr R, Yaksh TL. PMID: 12563112.
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    222. Inflammatory masses associated with intrathecal drug infusion: a review of preclinical evidence and human data. Pain Med. 2002 Dec; 3(4):300-12. Yaksh TL, Hassenbusch S, Burchiel K, Hildebrand KR, Page LM, Coffey RJ. PMID: 15099235.
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    223. Safety in numbers: how do we study toxicity of spinal analgesics? Anesthesiology. 2002 Nov; 97(5):1047-9. Eisenach JC, Yaksh TL. PMID: 12411784.
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    224. Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness. Physiol Genomics. 2002 Oct 29; 11(2):65-72. Khan IM, Singletary E, Alemayehu A, Stanislaus S, Printz MP, Yaksh TL, Taylor P. PMID: 12388796.
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    225. Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain. Pain. 2002 Oct; 99(3):397-406. Luger NM, Sabino MAC, Schwei MJ, Mach DB, Pomonis JD, Keyser CP, Rathbun M, Clohisy DR, Honore P, Yaksh TL, Mantyh PW. PMID: 12406514.
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    226. Phase I safety assessment of intrathecal ketorolac. Pain. 2002 Oct; 99(3):599-604. Eisenach JC, Curry R, Hood DD, Yaksh TL. PMID: 12406536.
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    227. Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury. Exp Brain Res. 2002 Dec; 147(4):456-63. Cizkova D, Marsala J, Lukacova N, Marsala M, Jergova S, Orendacova J, Yaksh TL. PMID: 12444477.
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    228. Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands. J Med Chem. 2002 Aug 15; 45(17):3746-54. Rew Y, Malkmus S, Svensson C, Yaksh TL, Chung NN, Schiller PW, Cassel JA, DeHaven RN, Taulane JP, Goodman M. PMID: 12166947.
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    229. Rapid quantification of the delta-opioid receptor selective enkephalin DPDPE in canine cerebrospinal fluid by liquid chromatography--mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 25; 772(1):73-9. Rossi S, Yaksh T. PMID: 12016017.
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    230. Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury. Anesth Analg. 2002 Apr; 94(4):968-74, table of contents. Nozaki-Taguchi N, Yaksh TL. PMID: 11916806.
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    231. Pharmacology of spinal glutamatergic receptors in post-thermal injury-evoked tactile allodynia and thermal hyperalgesia. Anesthesiology. 2002 Mar; 96(3):617-26. Nozaki-Taguchi N, Yaksh TL. PMID: 11873037.
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    232. Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve. J Neurosci. 2002 Jan 15; 22(2):536-45. Schäfers M, Geis C, Brors D, Yaksh TL, Sommer C. PMID: 11784800.
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    233. Inhibition of spinal protein kinase Calpha expression by an antisense oligonucleotide attenuates morphine infusion-induced tolerance. Neuroscience. 2002; 113(1):99-107. Hua XY, Moore A, Malkmus S, Murray SF, Dean N, Yaksh TL, Butler M. PMID: 12123688.
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    234. Future advances in pain pharmacology: what does the present say about the future? Proc West Pharmacol Soc. 2002; 45:211-8. Yaksh TL. PMID: 12434582.
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    235. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annu Rev Pharmacol Toxicol. 2002; 42:553-83. Svensson CI, Yaksh TL. PMID: 11807183.
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    236. Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia. J Clin Pharmacol. 2002 Jan; 42(1):70-80. Wallace MS, Ridgeway B, Leung A, Schulteis G, Yaksh TL. PMID: 11808827.
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    237. Effects of continuous lumbar intrathecal infusion of leptin in rats on weight regulation. Neuroscience. 2002; 110(4):703-10. Yaksh TL, Scott B, LeBel CL. PMID: 11934477.
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    238. Spinal nicotinic receptor activity in a genetic model of hypertension. Clin Exp Hypertens. 2001 Oct; 23(7):555-68. Khan IM, Stanislaus S, Zhang L, Vaughn D, Printz MP, Yaksh TL, Taylor P. PMID: 11710757.
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    239. Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists. Anesthesiology. 2001 Oct; 95(4):965-73. Sorkin LS, Yaksh TL, Doom CM. PMID: 11605940.
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    240. The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. J Neurosci. 2001 Aug 15; 21(16):5847-53. Yaksh TL, Dirig DM, Conway CM, Svensson C, Luo ZD, Isakson PC. PMID: 11487607.
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    241. Vincristine-induced allodynia in the rat. Pain. 2001 Jul; 93(1):69-76. Nozaki-Taguchi N, Chaplan SR, Higuera ES, Ajakwe RC, Yaksh TL. PMID: 11406340.
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    242. Sensory neurons are PARtial to pain. Nat Med. 2001 Jul; 7(7):772-3. Mantyh PW, Yaksh TL. PMID: 11433334.
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    243. An automated flinch detecting system for use in the formalin nociceptive bioassay. J Appl Physiol (1985). 2001 Jun; 90(6):2386-402. Yaksh TL, Ozaki G, McCumber D, Rathbun M, Svensson C, Malkmus S, Yaksh MC. PMID: 11356806.
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    244. A-85380 and epibatidine each interact with disparate spinal nicotinic receptor subtypes to achieve analgesia and nociception. J Pharmacol Exp Ther. 2001 Apr; 297(1):230-9. Khan IM, Stanislaus S, Zhang L, Taylor P, Yaksh TL. PMID: 11259549.
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    245. Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. J Neurosci. 2001 Mar 15; 21(6):1868-75. Luo ZD, Chaplan SR, Higuera ES, Sorkin LS, Stauderman KA, Williams ME, Yaksh TL. PMID: 11245671.
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    246. Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain. Pain. 2001 Mar; 91(1-2):177-87. Leung A, Wallace MS, Ridgeway B, Yaksh T. PMID: 11240090.
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    247. Inhibition of spinal protein kinase C blocks substance P-mediated hyperalgesia. Brain Res. 2000 Sep 22; 877(2):314-21. Wajima Z, Hua XY, Yaksh TL. PMID: 10986346.
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    248. Intrathecal nalbuphine after cesarean delivery: are we ready? Anesth Analg. 2000 Sep; 91(3):505-8. Yaksh T, Birnbach DJ. PMID: 10960366.
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    249. Evidence-based review of the literature on intrathecal delivery of pain medication. J Pain Symptom Manage. 2000 Aug; 20(2):S12-36. Bennett G, Serafini M, Burchiel K, Buchser E, Classen A, Deer T, Du Pen S, Ferrante FM, Hassenbusch SJ, Lou L, Maeyaert J, Penn R, Portenoy RK, Rauck R, Willis KD, Yaksh T. PMID: 10989255.
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    250. Clinical guidelines for intraspinal infusion: report of an expert panel. PolyAnalgesic Consensus Conference 2000. J Pain Symptom Manage. 2000 Aug; 20(2):S37-43. Bennett G, Burchiel K, Buchser E, Classen A, Deer T, Du Pen S, Ferrante FM, Hassenbusch SJ, Lou L, Maeyaert J, Penn R, Portenoy RK, Rauck R, Serafini M, Willis KD, Yaksh T. PMID: 10989256.
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    251. Future directions in the management of pain by intraspinal drug delivery. J Pain Symptom Manage. 2000 Aug; 20(2):S44-50. Bennett G, Deer T, Du Pen S, Rauck R, Yaksh T, Hassenbusch SJ. PMID: 10989257.
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    252. The effects of intrathecal morphine encapsulated in L- and D-dipalmitoylphosphatidyl choline liposomes on acute nociception in rats. Anesth Analg. 2000 Aug; 91(2):423-8. Nishiyama T, Ho RJ, Shen DD, Yaksh TL. PMID: 10910861.
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    253. Transient spinal cord ischemia in rat: the time course of spinal FOS protein expression and the effect of intraischemic hypothermia (27 degrees C). Cell Mol Neurobiol. 2000 Jun; 20(3):351-65. Yang LC, Orendacova J, Wang V, Ishikawa T, Yaksh TL, Marsala M. PMID: 10789833.
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    254. Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion. Pain. 2000 Apr; 85(3):395-404. Granados-Soto V, Kalcheva I, Hua XY, Newton A, Yaksh TL. PMID: 10781912.
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    255. Long-term spinal analgesic delivery: a review of the preclinical and clinical literature. Reg Anesth Pain Med. 2000 Mar-Apr; 25(2):117-57. Wallace M, Yaksh TL. PMID: 10746527.
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    256. Concentration-effect relationship of intravenous lidocaine on the allodynia of complex regional pain syndrome types I and II. Anesthesiology. 2000 Jan; 92(1):75-83. Wallace MS, Ridgeway BM, Leung AY, Gerayli A, Yaksh TL. PMID: 10638902.
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    257. Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABA(A) receptor antagonist. Neuroscience. 2000; 95(3):781-6. Ishikawa T, Marsala M, Sakabe T, Yaksh TL. PMID: 10670445.
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    258. Safety assessment of encapsulated morphine delivered epidurally in a sustained-release multivesicular liposome preparation in dogs. Drug Deliv. 2000 Jan-Mar; 7(1):27-36. Yaksh TL, Provencher JC, Rathbun ML, Myers RR, Powell H, Richter P, Kohn FR. PMID: 10895417.
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    259. Inhibition of spinal protein kinase C reduces nerve injury-induced tactile allodynia in neuropathic rats. Neurosci Lett. 1999 Dec 03; 276(2):99-102. Hua XY, Chen P, Yaksh TL. PMID: 10624801.
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    260. Mechanical allodynia in rats is blocked by a Ca2+ permeable AMPA receptor antagonist. Neuroreport. 1999 Nov 26; 10(17):3523-6. Sorkin LS, Yaksh TL, Doom CM. PMID: 10619637.
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    261. A drug has to do what a drug has to do. Anesth Analg. 1999 Nov; 89(5):1075-7. Yaksh TL. PMID: 10553814.
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    262. Neuronal nitric oxide synthase mRNA upregulation in rat sensory neurons after spinal nerve ligation: lack of a role in allodynia development. J Neurosci. 1999 Nov 01; 19(21):9201-8. Luo ZD, Chaplan SR, Scott BP, Cizkova D, Calcutt NA, Yaksh TL. PMID: 10531423.
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    263. Generation and analysis of GluR5(Q636R) kainate receptor mutant mice. J Neurosci. 1999 Oct 15; 19(20):8757-64. Sailer A, Swanson GT, Pérez-Otaño I, O'Leary L, Malkmus SA, Dyck RH, Dickinson-Anson H, Schiffer HH, Maron C, Yaksh TL, Gage FH, O'Gorman S, Heinemann SF. PMID: 10516295.
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    264. Evaluation of interaction between gabapentin and ibuprofen on the formalin test in rats. Anesthesiology. 1999 Oct; 91(4):1006-13. Yoon MH, Yaksh TL. PMID: 10519504.
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    265. Preclinical toxicity screening of intrathecal adenosine in rats and dogs. Anesthesiology. 1999 Sep; 91(3):824-32. Chiari A, Yaksh TL, Myers RR, Provencher J, Moore L, Lee CS, Eisenach JC. PMID: 10485794.
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    266. Regulation of spinal nociceptive processing: where we went when we wandered onto the path marked by the gate. Pain. 1999 Aug; Suppl 6:S149-S152. Yaksh TL. PMID: 10491984.
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    267. Spinal systems and pain processing: development of novel analgesic drugs with mechanistically defined models. Trends Pharmacol Sci. 1999 Aug; 20(8):329-37. Yaksh TL. PMID: 10431212.
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    268. The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat. Anesth Analg. 1999 Aug; 89(2):434-9. Yoon MH, Yaksh TL. PMID: 10439761.
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    269. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):7680-6. Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, Marsala M. PMID: 10393880.
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    270. Pharmacokinetics and efficacy of epidurally delivered sustained-release encapsulated morphine in dogs. Anesthesiology. 1999 May; 90(5):1402-12. Yaksh TL, Provencher JC, Rathbun ML, Kohn FR. PMID: 10319789.
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    271. Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J Pharmacol Exp Ther. 1999 Apr; 289(1):494-502. DeHaven-Hudkins DL, Burgos LC, Cassel JA, Daubert JD, DeHaven RN, Mansson E, Nagasaka H, Yu G, Yaksh T. PMID: 10087042.
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    272. Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids. Neuroscience. 1999 Mar; 89(2):525-34. Hua XY, Chen P, Marsala M, Yaksh TL. PMID: 10077333.
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    273. In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin. Br J Pharmacol. 1999 Mar; 126(6):1333-40. Dirig DM, Yaksh TL. PMID: 10217526.
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    274. Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist--loperamide. Anesthesiology. 1999 Jan; 90(1):225-34. Nozaki-Taguchi N, Yaksh TL. PMID: 9915332.
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    275. Spinal synthesis and release of prostanoids after peripheral injury and inflammation. Adv Exp Med Biol. 1999; 469:401-8. Dirig DM, Yaksh TL. PMID: 10667359.
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    276. Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists. Neuropharmacology. 1998 Dec; 37(12):1515-25. Khan IM, Buerkle H, Taylor P, Yaksh TL. PMID: 9886674.
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    277. New epidural drugs: primum non nocere. Anesth Analg. 1998 Nov; 87(5):1211-2. Eisenach JC, James FM, Gordh T, Yaksh TL. PMID: 9806714.
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    278. A novel model of primary and secondary hyperalgesia after mild thermal injury in the rat. Neurosci Lett. 1998 Sep 18; 254(1):25-8. Nozaki-Taguchi N, Yaksh TL. PMID: 9780083.
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    279. Effects of intrathecal NMDA and non-NMDA antagonists on acute thermal nociception and their interaction with morphine. Anesthesiology. 1998 Sep; 89(3):715-22. Nishiyama T, Yaksh TL, Weber E. PMID: 9743410.
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    280. Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat. Br J Anaesth. 1998 Aug; 81(2):208-15. Buerkle H, Yaksh TL. PMID: 9813525.
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    281. Synthesis and biological activity of a novel methylamine-bridged enkephalin analogue (MABE): a new route to cyclic peptides and peptidomimetics. J Med Chem. 1998 Jul 02; 41(14):2631-5. Shreder K, Zhang L, Dang T, Yaksh TL, Umeno H, DeHaven R, Daubert J, Goodman M. PMID: 9651168.
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    282. Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. J Pharmacol Exp Ther. 1998 Jun; 285(3):1031-8. Dirig DM, Isakson PC, Yaksh TL. PMID: 9618405.
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    283. Neurodegeneration induced by reversed microdialysis of NMDA; a quantitative model for excitotoxicity in vivo. Brain Res. 1998 Apr 13; 789(2):347-50. Vanický I, Marsala M, Yaksh TL. PMID: 9573401.
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    284. Effects of endotracheal intubation on airway neuropeptide content, arterial oxygenation and lung volumes in anaesthetized rats. Eur J Clin Invest. 1998 Mar; 28(3):249-55. Högman M, Reber A, Hua XY, Dueck R, Yaksh TL. PMID: 9568472.
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    285. Effect of continuous spinal remifentanil infusion on behaviour and spinal glutamate release evoked by subcutaneous formalin in the rat. Br J Anaesth. 1998 Mar; 80(3):348-53. Buerkle H, Marsala M, Yaksh TL. PMID: 9623437.
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    286. The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. Anesth Analg. 1998 Feb; 86(2):348-54. Jun JH, Yaksh TL. PMID: 9459247.
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    287. Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy. J Neurochem. 1998 Feb; 70(2):688-98. Hua XY, Chen P, Polgar E, Nagy I, Marsala M, Phillips E, Wollaston L, Urban L, Yaksh TL, Webb M. PMID: 9453563.
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    288. Mechanism of action of nonsteroidal anti-inflammatory drugs. Cancer Invest. 1998; 16(7):509-27. Yaksh TL, Dirig DM, Malmberg AB. PMID: 9774958.
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    289. Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia. Anesthesiology. 1998 Jan; 88(1):196-205. Partridge BJ, Chaplan SR, Sakamoto E, Yaksh TL. PMID: 9447873.
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    290. [Pharmacology of spinal facilitation: the basis for preventive analgesia]. Rev Esp Anestesiol Reanim. 1998 Jan; 45(1):17-23. Yáñez AM, Peleteiro-Ramos R, Camba MA, Yaksh TL. PMID: 9580459.
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    291. Fate of the predominant phospholipid component of DepoFoam drug delivery matrix after intrathecal administration of sustained-release encapsulated cytarabine in rats. Drug Deliv. 1998; 5(2):143-51. Kohn FR, Malkmus SA, Brownson EA, Rossi SS, Yaksh TL. PMID: 19570006.
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    292. Adrenomedullary secretion of DOPA, catecholamines, catechol metabolites, and neuropeptides. J Neurochem. 1997 Dec; 69(6):2413-20. Chritton SL, Chinnow SL, Grabau C, Dousa MK, Lucas D, Roddy D, Yaksh TL, Tyce GM. PMID: 9375673.
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    293. Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli. J Neurosci Methods. 1997 Oct 03; 76(2):183-91. Dirig DM, Salami A, Rathbun ML, Ozaki GT, Yaksh TL. PMID: 9350970.
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    294. Intravenous lidocaine: effects on controlling pain after anti-GD2 antibody therapy in children with neuroblastoma--a report of a series. Anesth Analg. 1997 Oct; 85(4):794-6. Wallace MS, Lee J, Sorkin L, Dunn JS, Yaksh T, Yu A. PMID: 9322457.
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    295. Characterization of muscarinic receptor subtypes that mediate antinociception in the rat spinal cord. Anesth Analg. 1997 Oct; 85(4):847-53. Naguib M, Yaksh TL. PMID: 9322468.
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    296. Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release. Eur J Pharmacol. 1997 Jul 23; 331(2-3):155-60. Dirig DM, Konin GP, Isakson PC, Yaksh TL. PMID: 9274974.
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    297. Antinociception induced by civamide, an orally active capsaicin analogue. Pain. 1997 Jul; 71(3):313-22. Hua XY, Chen P, Hwang J, Yaksh TL. PMID: 9231875.
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    298. Kinetic and safety studies on intrathecally infused recombinant-methionyl human brain-derived neurotrophic factor in dogs. Fundam Appl Toxicol. 1997 Jul; 38(1):89-100. Yaksh TL, Rathbun ML, Dragani JC, Malkmus S, Bourdeau AR, Richter P, Powell H, Myers RR, Lebel CP. PMID: 9268608.
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    299. Technique of selective spinal cord cooling in rat: methodology and application. J Neurosci Methods. 1997 Jun 06; 74(1):97-106. Marsala M, Galik J, Ishikawa T, Yaksh TL. PMID: 9210579.
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    300. Concentration-effect relations for intravenous lidocaine infusions in human volunteers: effects on acute sensory thresholds and capsaicin-evoked hyperpathia. Anesthesiology. 1997 Jun; 86(6):1262-72. Wallace MS, Laitin S, Licht D, Yaksh TL. PMID: 9197294.
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    301. Spinal infusion of N-methyl-D-aspartate antagonist MK801 induces hypersensitivity to the spinal alpha-2 agonist ST91 in the rat. J Pharmacol Exp Ther. 1997 Jun; 281(3):1219-25. Dunbar SA, Yaksh TL. PMID: 9190856.
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    302. Temperature dependency of basal and evoked release of amino acids and calcitonin gene-related peptide from rat dorsal spinal cord. J Neurosci. 1997 Jun 01; 17(11):4406-14. Dirig DM, Hua XY, Yaksh TL. PMID: 9151757.
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    303. Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat. Reg Anesth. 1997 May-Jun; 22(3):249-56. Hwang JH, Yaksh TL. PMID: 9168217.
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    304. Epibatidine binding sites and activity in the spinal cord. Brain Res. 1997 Apr 11; 753(2):269-82. Khan IM, Yaksh TL, Taylor P. PMID: 9125412.
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    305. Knee joint inflammation attenuates spinal FOS expression after unilateral paw formalin injection in rat. Neurosci Lett. 1997 Apr 04; 225(2):89-92. Yang LC, Marsala M, Orendacova J, Yaksh TL. PMID: 9147381.
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    306. Effect of transient naloxone antagonism on tolerance development in rats receiving continuous spinal morphine infusion. Pain. 1997 Apr; 70(2-3):125-32. Ibuki T, Dunbar SA, Yaksh TL. PMID: 9150285.
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    307. An improved method for the measurement of lidocaine and its metabolites in rat plasma. Ther Drug Monit. 1997 Apr; 19(2):179-84. Rossi SS, Moore AC, Hagey LR, Yaksh TL, Chaplan SR. PMID: 9108647.
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    308. Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP) and calcitonin gene-related peptide (CGRP) from rat spinal cord in vivo. Regul Pept. 1997 Mar 26; 69(2):83-7. Zhang Y, Malmberg AB, Yaksh TL, Sjölund B, Sundler F, Håkanson R. PMID: 9178350.
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    309. The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat. Pain. 1997 Mar; 70(1):15-22. Hwang JH, Yaksh TL. PMID: 9106805.
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    310. Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. J Pharmacol Exp Ther. 1997 Feb; 280(2):829-38. Chaplan SR, Malmberg AB, Yaksh TL. PMID: 9023297.
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    311. Hyperalgesia-associated spinal synthesis and release of prostaglandins. Adv Exp Med Biol. 1997; 433:205-8. Dirig DM, Yaksh TL. PMID: 9561136.
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    312. Differential effects of two intraventricularly injected alpha 2 agonists, ST-91 and dexmedetomidine, on electroencephalogram, feeding, and electromyogram. Anesth Analg. 1997 Jan; 84(1):133-8. Dowlatshahi P, Yaksh TL. PMID: 8989014.
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    313. An animal model of pain produced by systemic administration of an immunotherapeutic anti-ganglioside antibody. Pain. 1997 Jan; 69(1-2):119-25. Slart R, Yu AL, Yaksh TL, Sorkin LS. PMID: 9060021.
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    314. The pharmacokinetics of lignocaine in humans during a computer-controlled infusion. Eur J Pain. 1997; 1(2):141-8. Dyck JB, Wallace MS, Lu JQ, Rossi SS, Yaksh TL. PMID: 15102415.
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    315. Pain after injury: some basic mechanisms. J Fla Med Assoc. 1997 Jan; 84(1):16-9. Yaksh TL. PMID: 9037993.
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    316. Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiol Scand. 1997 Jan; 41(1 Pt 2):94-111. Yaksh TL. PMID: 9061092.
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    317. Thermal hyperalgesia in rat evoked by intrathecal substance P at multiple stimulus intensities reflects an increase in the gain of nociceptive processing. Neurosci Lett. 1996 Dec 13; 220(2):93-6. Dirig DM, Yaksh TL. PMID: 8981481.
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    318. Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. Pain. 1996 Dec; 68(2-3):293-9. Calcutt NA, Jorge MC, Yaksh TL, Chaplan SR. PMID: 9121817.
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    319. Spinal nicotinic receptor expression in spontaneously hypertensive rats. Hypertension. 1996 Dec; 28(6):1093-9. Khan IM, Youngblood KL, Printz MP, Yaksh TL, Taylor P. PMID: 8952602.
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    320. Effect of spinal kainic acid receptor activation on spinal amino acid and prostaglandin E2 release in rat. Neuroscience. 1996 Nov; 75(2):453-61. Yang LC, Marsala M, Yaksh TL. PMID: 8931009.
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    321. Characterization of time course of spinal amino acids, citrulline and PGE2 release after carrageenan/kaolin-induced knee joint inflammation: a chronic microdialysis study. Pain. 1996 Oct; 67(2-3):345-54. Yang LC, Marsala M, Yaksh TL. PMID: 8951928.
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    322. Peripheral and spinal actions of opioids in the blockade of the autonomic response evoked by compression of the inflamed knee joint. Anesthesiology. 1996 Oct; 85(4):808-16. Nagasaka H, Awad H, Yaksh TL. PMID: 8873551.
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    323. Effects of spinal naloxone and naltrindole on the antinociceptive action of intrathecally administered dexmedetomidine. J Anesth. 1996 Sep; 10(3):194-8. Takano Y, Takano M, Sato I, Yaksh TL. PMID: 23839625.
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    324. Equianalgesic doses of subcutaneous but not intrathecal morphine alter phenotypic expression of cell surface markers and mitogen-induced proliferation in rat lymphocytes. Anesthesiology. 1996 Aug; 85(2):355-65. Hamra JG, Yaksh TL. PMID: 8712452.
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    325. Computer-controlled lidocaine infusion for the evaluation of neuropathic pain after peripheral nerve injury. Pain. 1996 Jul; 66(1):69-77. Wallace MS, Dyck BJ, Rossi SS, Yaksh TL. PMID: 8857633.
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    326. Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats. J Pharmacol Exp Ther. 1996 Jul; 278(1):97-106. Khan IM, Marsala M, Printz MP, Taylor P, Yaksh TL. PMID: 8764340.
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    327. Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists. J Pharmacol Exp Ther. 1996 Jun; 277(3):1642-8. Lee YW, Yaksh TL. PMID: 8667233.
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    328. Halothane inhibits T cell proliferation and interleukin-2 receptor expression in rats. Immunopharmacol Immunotoxicol. 1996 May; 18(2):323-36. Hamra JG, Yaksh TL. PMID: 8771374.
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    329. Concurrent spinal infusion of MK801 blocks spinal tolerance and dependence induced by chronic intrathecal morphine in the rat. Anesthesiology. 1996 May; 84(5):1177-88. Dunbar S, Yaksh TL. PMID: 8624012.
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    330. Spinal amino acid release and precipitated withdrawal in rats chronically infused with spinal morphine. J Neurosci. 1996 Apr 15; 16(8):2758-66. Jhamandas KH, Marsala M, Ibuki T, Yaksh TL. PMID: 8786451.
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    331. The effect of pituitary adenylate cyclase activating peptide (PACAP) on the nociceptive formalin test. Neurosci Lett. 1996 Apr 05; 207(3):187-90. Zhang Y, Malmberg AB, Sjölund B, Yaksh TL. PMID: 8728481.
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    332. Continuous intrathecal administration of shortlasting mu opioids remifentanil and alfentanil in the rat. Anesthesiology. 1996 Apr; 84(4):926-35. Buerkle H, Yaksh TL. PMID: 8638848.
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    333. [Concurrent characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABAA receptor antagonists]. Masui. 1996 Apr; 45(4):439-44. Ishikawa T, Yaksh TL. PMID: 8725598.
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    334. Changes in spontaneous unit activity in lumbar spinal cord after reversible aortic occlusion in the rat. Neurosci Lett. 1996 Mar 22; 207(1):45-8. Galik J, Marsala M, Yaksh TL. PMID: 8710206.
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    335. Effect of spinal infusion of L-NAME, a nitric oxide synthase inhibitor, on spinal tolerance and dependence induced by chronic intrathecal morphine in the rat. Neurosci Lett. 1996 Mar 22; 207(1):33-6. Dunbar S, Yaksh TL. PMID: 8710203.
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    336. Simultaneous extraction of sufentanil and midazolam from human plasma. Clin Chim Acta. 1996 Jan 15; 244(1):103-10. Rossi SS, Dyck JB, Yaksh TL. PMID: 8919205.
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    337. Horizons in Pain Research. San Diego, California, May 19-21, 1995. Anesthesiology. 1996 Jan; 84(1):245-8. Yaksh TL. PMID: 8572351.
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    338. Comparison of the spinal actions of the mu-opioid remifentanil with alfentanil and morphine in the rat. Anesthesiology. 1996 Jan; 84(1):94-102. Buerkle H, Yaksh TL. PMID: 8572360.
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    339. Release of beta-endorphin immunoreactivity into ventriculo-cisternal perfusate by lumbar intrathecal capsaicin in the rat. Brain Res. 1995 Dec 01; 701(1-2):192-200. Bach FW, Yaksh TL. PMID: 8925284.
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    340. Antinociception and side effects of L- and D-dipalmitoylphosphatidyl choline liposome-encapsulated alfentanil after spinal delivery in rats. Pharmacol Toxicol. 1995 Nov; 77(5):333-40. Isackson J, Wallace MS, Ho RJ, Shen DD, Yaksh TL. PMID: 8778746.
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    341. The spinal loop dialysis catheter: characterization of use in the unanesthetized rat. J Neurosci Methods. 1995 Nov; 62(1-2):43-53. Marsala M, Malmberg AB, Yaksh TL. PMID: 8750084.
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    342. Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neurosci Lett. 1995 Oct 20; 199(2):111-4. Lee YW, Chaplan SR, Yaksh TL. PMID: 8584236.
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    343. Different effects of two aldose reductase inhibitors on nociception and prostaglandin E. Eur J Pharmacol. 1995 Oct 16; 285(2):189-97. Calcutt NA, Li L, Yaksh TL, Malmberg AB. PMID: 8566138.
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    344. Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model. J Pharmacol Exp Ther. 1995 Oct; 275(1):219-27. Dirig DM, Yaksh TL. PMID: 7562553.
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    345. Characterization of the spinal antinociceptive activity of constrained peptidomimetic opioids. J Pharmacol Exp Ther. 1995 Oct; 275(1):63-72. Yaksh TL, Malmberg AB, Ro S, Schiller P, Goodman M. PMID: 7562596.
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    346. Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats. Anesthesiology. 1995 Oct; 83(4):775-85. Chaplan SR, Bach FW, Shafer SL, Yaksh TL. PMID: 7574057.
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    347. Cerebrospinal fluid beta-endorphin in models of hyperalgesia in the rat. Regul Pept. 1995 Sep 22; 59(1):79-86. Bach FW, Chaplan SR, Jang J, Yaksh TL. PMID: 12506417.
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    348. Release into ventriculo-cisternal perfusate of beta-endorphin- and Met-enkephalin-immunoreactivity: effects of electrical stimulation in the arcuate nucleus and periaqueductal gray of the rat. Brain Res. 1995 Sep 04; 690(2):167-76. Bach FW, Yaksh TL. PMID: 8535833.
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    349. Differential right shifts in the dose-response curve for intrathecal morphine and sufentanil as a function of stimulus intensity. Pain. 1995 Sep; 62(3):321-328. Dirig DM, Yaksh TL. PMID: 8657432.
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    350. Pharmacology of calcitonin gene related peptide release from sensory terminals in the rat trachea. Can J Physiol Pharmacol. 1995 Jul; 73(7):999-1006. Hua XY, Wong S, Jinno S, Yaksh TL. PMID: 8846444.
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    351. Touch-evoked agitation produced by spinally administered phospholipid emulsion and liposomes in rats. Structure-activity relation. Anesthesiology. 1995 May; 82(5):1189-98. Yanez AM, Wallace M, Ho R, Shen D, Yaksh TL. PMID: 7741294.
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    352. Highly potent side chain-main chain cyclized dermorphin-deltorphin analogues: an integrated approach including synthesis, bioassays, NMR spectroscopy and molecular modelling. J Pept Sci. 1995 May-Jun; 1(3):157-74. Ro S, Zhu Q, Lee CW, Goodman M, Darlak K, Spatola AF, Chung NN, Schiller PW, Malmberg AB, Yaksh TL, et al. PMID: 9222993.
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    353. Release of beta-endorphin immunoreactivity from brain by activation of a hypothalamic N-methyl-D-aspartate receptor. Neuroscience. 1995 Apr; 65(3):775-83. Bach FW, Yaksh TL. PMID: 7609876.
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    354. Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats. J Neurosci. 1995 Apr; 15(4):2768-76. Malmberg AB, Yaksh TL. PMID: 7722627.
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    355. Analysis of drug interaction between intrathecal clonidine and MK-801 in peripheral neuropathic pain rat model. Anesthesiology. 1995 Mar; 82(3):741-8. Lee YW, Yaksh TL. PMID: 7879942.
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    356. The effect of morphine on formalin-evoked behaviour and spinal release of excitatory amino acids and prostaglandin E2 using microdialysis in conscious rats. Br J Pharmacol. 1995 Mar; 114(5):1069-75. Malmberg AB, Yaksh TL. PMID: 7780642.
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    357. Effects of intrathecal mu, delta, and kappa agonists on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats. Anesth Analg. 1995 Mar; 80(3):437-43. Nagasaka H, Yaksh TL. PMID: 7864404.
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    358. Studies on the safety of chronically administered intrathecal neostigmine methylsulfate in rats and dogs. Anesthesiology. 1995 Feb; 82(2):412-27. Yaksh TL, Grafe MR, Malkmus S, Rathbun ML, Eisenach JC. PMID: 7856900.
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    359. Retrovirus-mediated expression of an artificial beta-endorphin precursor in primary fibroblasts. J Neurochem. 1995 Feb; 64(2):475-81. Beutler AS, Banck MS, Bach FW, Gage FH, Porreca F, Bilsky EJ, Yaksh TL. PMID: 7830038.
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    360. Cardiorespiratory and spinal cord blood flow effects of intrathecal neostigmine methylsulfate, clonidine, and their combination in sheep. Anesthesiology. 1995 Feb; 82(2):428-35. Hood DD, Eisenach JC, Tong C, Tommasi E, Yaksh TL. PMID: 7856901.
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    361. Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists. J Pharmacol Exp Ther. 1995 Jan; 272(1):207-14. Yaksh TL, Pogrel JW, Lee YW, Chaplan SR. PMID: 7815335.
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    362. Future directions in the pharmacological management of hyperalgesic and allodynic pain states: the NMDA receptor. NIDA Res Monogr. 1995; 147:84-103. Yaksh TL, Chaplan SR, Malmberg AB. PMID: 8742782.
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    363. Effect of continuous intrathecal infusion of omega-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain. 1995 Jan; 60(1):83-90. Malmberg AB, Yaksh TL. PMID: 7715945.
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    364. Capsaicin-evoked prostaglandin E2 release in spinal cord slices: relative effect of cyclooxygenase inhibitors. Eur J Pharmacol. 1994 Dec 27; 271(2-3):293-9. Malmberg AB, Yaksh TL. PMID: 7705429.
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    365. Stimulatory pathways and sites of action of intrathecally administered nicotinic agents. J Pharmacol Exp Ther. 1994 Dec; 271(3):1550-7. Khan IM, Taylor P, Yaksh TL. PMID: 7996469.
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    366. Long-term perfusion of the cerebroventricular system of dogs without leakage to the peripheral circulation. Am J Physiol. 1994 Nov; 267(5 Pt 2):R1309-19. Nitecki S, Karmeli R, Harty GJ, Kamei C, Yaksh TL, Szurszewski JH. PMID: 7977859.
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    367. Analgesic and neurotoxic effects of intrathecal corticosteroids in rats. Anesthesiology. 1994 Nov; 81(5):1198-205. Abram SE, Marsala M, Yaksh TL. PMID: 7978478.
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    368. Augmented responses to intrathecal nicotinic agonists in spontaneous hypertension. Hypertension. 1994 Nov; 24(5):611-9. Khan IM, Printz MP, Yaksh TL, Taylor P. PMID: 7960022.
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    369. Characterization of muscarinic receptors involved in tracheal CGRP release. Neuroreport. 1994 Oct 27; 5(16):2133-6. Hua XY, Back SM, Yaksh TL. PMID: 7865762.
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    370. Multiple mechanisms for the effects of capsaicin, bradykinin and nicotine on CGRP release from tracheal afferent nerves: role of prostaglandins, sympathetic nerves and mast cells. Neuropharmacology. 1994 Oct; 33(10):1147-54. Hua XY, Jinno S, Back SM, Tam EK, Yaksh TL. PMID: 7862250.
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    371. Pharmacology and toxicology of chronically infused epidural clonidine.HCl in dogs. Fundam Appl Toxicol. 1994 Oct; 23(3):319-35. Yaksh TL, Rathbun M, Jage J, Mirzai T, Grafe M, Hiles RA. PMID: 7835532.
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    372. Effect of graded hypothermia (27 degrees to 34 degrees C) on behavioral function, histopathology, and spinal blood flow after spinal ischemia in rat. Stroke. 1994 Oct; 25(10):2038-46. Marsala M, Vanicky I, Yaksh TL. PMID: 8091450.
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    373. Antinociception and side effects of liposome-encapsulated alfentanil after spinal delivery in rats. Anesth Analg. 1994 Oct; 79(4):778-86. Wallace MS, Yanez AM, Ho RJ, Shen DD, Yaksh TL. PMID: 7943792.
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    374. Spinal delivery of sufentanil, alfentanil, and morphine in dogs. Physiologic and toxicologic investigations. Anesthesiology. 1994 Oct; 81(4):899-920. Sabbe MB, Grafe MR, Mjanger E, Tiseo PJ, Hill HF, Yaksh TL. PMID: 7943841.
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    375. Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. Pain. 1994 Sep; 58(3):413-420. Calcutt NA, Malmberg AB, Yamamoto T, Yaksh TL. PMID: 7838591.
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    376. Spinal somatostatin for patients with cancer. Risk-benefit assessment of an analgesic. Anesthesiology. 1994 Sep; 81(3):531-3. Yaksh TL. PMID: 7916545.
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    377. Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociception. J Neurosci. 1994 Aug; 14(8):4882-90. Malmberg AB, Yaksh TL. PMID: 8046458.
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    378. Differential temperature sensitivity of ischemia-induced glutamate release and eicosanoid production in rats. Brain Res. 1994 Jul 11; 650(2):205-11. Patel PM, Drummond JC, Cole DJ, Yaksh TL. PMID: 7953685.
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    379. Transient spinal ischemia in rat: characterization of spinal cord blood flow, extracellular amino acid release, and concurrent histopathological damage. J Cereb Blood Flow Metab. 1994 Jul; 14(4):604-14. Marsala M, Sorkin LS, Yaksh TL. PMID: 8014207.
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    380. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994 Jul; 53(1):55-63. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. PMID: 7990513.
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    381. Cardiovascular and behavioral responses to nicotinic agents administered intrathecally. J Pharmacol Exp Ther. 1994 Jul; 270(1):150-8. Khan IM, Taylor P, Yaksh TL. PMID: 8035311.
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    382. Ligand specificity of nicotinic acetylcholine receptors in rat spinal cord: studies with nicotine and cytisine. J Pharmacol Exp Ther. 1994 Jul; 270(1):159-66. Khan IM, Yaksh TL, Taylor P. PMID: 8035312.
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    383. Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with mu and alpha 2 receptor systems. Anesthesiology. 1994 Jun; 80(6):1338-48. Naguib M, Yaksh TL. PMID: 8010479.
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    384. Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia. J Pharmacol Exp Ther. 1994 Jun; 269(3):1117-23. Chaplan SR, Pogrel JW, Yaksh TL. PMID: 8014856.
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    385. Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat. Neurosci Lett. 1994 May 23; 173(1-2):193-6. Malmberg AB, Rafferty MF, Yaksh TL. PMID: 7936413.
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    386. Spinal and systemic action of the alpha 2 receptor agonist dexmedetomidine in dogs. Antinociception and carbon dioxide response. Anesthesiology. 1994 May; 80(5):1057-72. Sabbe MB, Penning JP, Ozaki GT, Yaksh TL. PMID: 7912480.
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    387. Transient spinal ischemia in the rat: characterization of behavioral and histopathological consequences as a function of the duration of aortic occlusion. J Cereb Blood Flow Metab. 1994 May; 14(3):526-35. Marsala M, Yaksh TL. PMID: 8163596.
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    388. Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test. Eur J Pharmacol. 1994 Apr 21; 256(2):205-9. Malmberg AB, Yaksh TL. PMID: 8050472.
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    389. Nicotine and acetylcholine induce release of calcitonin gene-related peptide from rat trachea. J Appl Physiol (1985). 1994 Apr; 76(4):1651-6. Jinno S, Hua XY, Yaksh TL. PMID: 8045845.
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    390. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat. Anesthesiology. 1994 Feb; 80(2):383-91; discussion 25A. Abram SE, Yaksh TL. PMID: 8311320.
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    391. Release of beta-endorphin and methionine-enkephalin into cerebrospinal fluid during deep brain stimulation for chronic pain. Effects of stimulation locus and site of sampling. J Neurosurg. 1993 Dec; 79(6):816-25. Young RF, Bach FW, Van Norman AS, Yaksh TL. PMID: 8246048.
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    392. Effects of colchicine applied to the peripheral nerve on the thermal hyperalgesia evoked with chronic nerve constriction. Pain. 1993 Nov; 55(2):227-233. Yamamoto T, Yaksh TL. PMID: 7508592.
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    393. Impaired induction of vasoactive intestinal polypeptide after sciatic nerve injury in the streptozotocin-diabetic rat. J Neurol Sci. 1993 Nov; 119(2):154-61. Calcutt NA, Mizisin AP, Yaksh TL. PMID: 8277329.
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    394. Anti-nociceptive effects of the GM1 ganglioside derivative AGF 44 on the formalin test in normal and streptozotocin-diabetic rats. Neurosci Lett. 1993 Oct 14; 161(1):45-8. Malmberg AB, Yaksh TL, Calcutt NA. PMID: 8255545.
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    395. Another call for patience instead of patients. Developing novel therapies for chronic pain. Anesthesiology. 1993 Oct; 79(4):637-40. Foley KM, Yaksh TL. PMID: 8214741.
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    396. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain. 1993 Sep; 54(3):291-300. Malmberg AB, Yaksh TL. PMID: 8233543.
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    397. Suppression of nociceptive responses by spinal mu opioid agonists: effects of stimulus intensity and agonist efficacy. Anesth Analg. 1993 Aug; 77(2):265-74. Saeki S, Yaksh TL. PMID: 8346825.
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    398. Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction. Anesthesiology. 1993 Aug; 79(2):270-81. Malmberg AB, Yaksh TL. PMID: 8102041.
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    399. Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801. Pain. 1993 Jul; 54(1):79-84. Yamamoto T, Yaksh TL. PMID: 8378105.
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    400. Effect of ibuprofen on regional eicosanoid production and neuronal injury after forebrain ischemia in rats. Brain Res. 1993 Jun 18; 614(1-2):315-24. Patel PM, Drummond JC, Sano T, Cole DJ, Kalkman CJ, Yaksh TL. PMID: 8348324.
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    401. Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat. Eur J Pharmacol. 1993 May 12; 236(1):89-96. Tiseo PJ, Yaksh TL. PMID: 8391455.
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    402. Pharmacology of the effects of bradykinin, serotonin, and histamine on the release of calcitonin gene-related peptide from C-fiber terminals in the rat trachea. J Neurosci. 1993 May; 13(5):1947-53. Hua XY, Yaksh TL. PMID: 8478685.
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    403. New horizons in our understanding of the spinal physiology and pharmacology of pain processing. Semin Oncol. 1993 Apr; 20(2 Suppl 1):6-18. Yaksh TL. PMID: 8475414.
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    404. Morphine, but not inhalation anesthesia, blocks post-injury facilitation. The role of preemptive suppression of afferent transmission. Anesthesiology. 1993 Apr; 78(4):713-21. Abram SE, Yaksh TL. PMID: 8385425.
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    405. The spinal pharmacology of facilitation of afferent processing evoked by high-threshold afferent input of the postinjury pain state. Curr Opin Neurol Neurosurg. 1993 Apr; 6(2):250-6. Yaksh TL. PMID: 8097639.
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    406. Release of calcitonin gene-related peptide (CGRP), substance P (SP), and vasoactive intestinal polypeptide (VIP) from rat spinal cord: modulation by alpha 2 agonists. Peptides. 1993 Mar-Apr; 14(2):371-8. Takano M, Takano Y, Yaksh TL. PMID: 7683402.
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    407. Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action. Pharmacol Rev. 1993 Mar; 45(1):43-85. Sawynok J, Yaksh TL. PMID: 8475169.
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    408. The role of focal nerve ischemia and Wallerian degeneration in peripheral nerve injury producing hyperesthesia. Anesthesiology. 1993 Feb; 78(2):308-16. Myers RR, Yamamoto T, Yaksh TL, Powell HC. PMID: 8439027.
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    409. Spinal actions of NSAIDS in blocking spinally mediated hyperalgesia: the role of cyclooxygenase products. Agents Actions Suppl. 1993; 41:89-100. Yaksh TL, Malmberg AB. PMID: 8317344.
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    410. Chronic spinal infusion of dexmedetomidine, ST-91 and clonidine: spinal alpha 2 adrenoceptor subtypes and intrinsic activity. J Pharmacol Exp Ther. 1993 Jan; 264(1):327-35. Takano Y, Yaksh TL. PMID: 8093729.
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    411. Toxicology of baclofen continuously infused into the spinal intrathecal space of the dog. Neurotoxicology. 1993; 14(4):397-410. Sabbe MB, Grafe MR, Pfeifer BL, Mirzai TH, Yaksh TL. PMID: 8164885.
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    412. Effects of intrathecal capsaicin and an NK-1 antagonist, CP,96-345, on the thermal hyperalgesia observed following unilateral constriction of the sciatic nerve in the rat. Pain. 1992 Dec; 51(3):329-334. Yamamoto T, Yaksh TL. PMID: 1337198.
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    413. Interaction of intrathecal morphine with bupivacaine and lidocaine in the rat. Anesthesiology. 1992 Dec; 77(6):1186-2000. Penning JP, Yaksh TL. PMID: 1466469.
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    414. The effect of cyclohexyladenosine on the periischemic increases of hippocampal glutamate and glycine in the rabbit. J Neurochem. 1992 Nov; 59(5):1884-92. Cantor SL, Zornow MH, Miller LP, Yaksh TL. PMID: 1357102.
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    415. Isobolographic and dose-response analyses of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB). J Pharmacol Exp Ther. 1992 Oct; 263(1):264-75. Malmberg AB, Yaksh TL. PMID: 1328610.
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    416. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J Pharmacol Exp Ther. 1992 Oct; 263(1):136-46. Malmberg AB, Yaksh TL. PMID: 1403779.
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    417. Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat. Anesthesiology. 1992 Oct; 77(4):757-63. Yamamoto T, Yaksh TL. PMID: 1416174.
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    418. The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord. Eur J Pharmacol. 1992 Sep 04; 219(3):465-8. Takano Y, Takano M, Yaksh TL. PMID: 1358645.
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    419. Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat. Anesthesiology. 1992 Sep; 77(3):507-12. Herold EE, Yaksh TL. PMID: 1519789.
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    420. Liposome encapsulation prolongs alfentanil spinal analgesia and alters systemic redistribution in the rat. Anesthesiology. 1992 Sep; 77(3):529-35. Bernards CM, Luger TJ, Malmberg AB, Hill HF, Yaksh TL. PMID: 1519790.
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    421. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science. 1992 Aug 28; 257(5074):1276-9. Malmberg AB, Yaksh TL. PMID: 1381521.
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    422. Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J Pharmacol Exp Ther. 1992 May; 261(2):764-72. Takano Y, Yaksh TL. PMID: 1349648.
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    423. Adrenal medullary secretion with splanchnic stimulation in spinal cats. J Auton Nerv Syst. 1992 May 01; 38(2):105-16. Stoddard SL, Tyce GM, Cook JA, Gaumann DM, Yaksh TL. PMID: 1619210.
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    424. Use of 2-hydroxypropyl-beta-cyclodextrin as an intrathecal drug vehicle with opioids. J Pharmacol Exp Ther. 1992 May; 261(2):592-600. Jang J, Yaksh TL, Hill HF. PMID: 1349642.
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    425. Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists. Pain. 1992 Apr; 49(1):121-128. Yamamoto T, Yaksh TL. PMID: 1594273.
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    426. Studies of morphine and D-ala2-D-leu5-enkephalin (DADLE) cross-tolerance after continuous intrathecal infusion in the rat. Anesthesiology. 1992 Apr; 76(4):596-603. Stevens CW, Yaksh TL. PMID: 1550284.
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    427. Suppression by spinal alpha-2 agonists of motor and autonomic responses evoked by low- and high-intensity thermal stimuli. J Pharmacol Exp Ther. 1992 Feb; 260(2):795-802. Saeki S, Yaksh TL. PMID: 1346645.
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    428. Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy. Neurosci Lett. 1992 Jan 20; 135(1):67-70. Yamamoto T, Yaksh TL. PMID: 1311824.
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    429. The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis. Brain Res. 1992 Jan 13; 569(2):255-67. Jensen TS, Yaksh TL. PMID: 1347242.
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    430. Brainstem excitatory amino acid receptors in nociception: microinjection mapping and pharmacological characterization of glutamate-sensitive sites in the brainstem associated with algogenic behavior. Neuroscience. 1992; 46(3):535-47. Jensen TS, Yaksh TL. PMID: 1347650.
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    431. Release of calcitonin gene-related peptide and tachykinins from the rat trachea. Peptides. 1992 Jan-Feb; 13(1):113-20. Hua XY, Yaksh TL. PMID: 1377821.
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    432. Comparison of the neurochemistry of the endogenous opioid systems in two brainstem pain-processing centers. Stereotact Funct Neurosurg. 1992; 59(1-4):15-9. al-Rodhan NR, Yaksh TL, Kelly PJ. PMID: 1295034.
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    433. Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. I. Opioid and nonopioid receptors. Anesthesiology. 1991 Nov; 75(5):817-26. Yamamoto T, Yaksh TL. PMID: 1659256.
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    434. Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after transient global ischemia in the rabbit brain. J Neurochem. 1991 Oct; 57(4):1370-9. Baker AJ, Zornow MH, Scheller MS, Yaksh TL, Skilling SR, Smullin DH, Larson AA, Kuczenski R. PMID: 1895110.
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    435. Structure-antinociceptive activity of neurotensin and some novel analogues in the periaqueductal gray region of the brainstem. Brain Res. 1991 Aug 23; 557(1-2):227-35. al-Rodhan NR, Richelson E, Gilbert JA, McCormick DJ, Kanba KS, Pfenning MA, Nelson A, Larson EW, Yaksh TL. PMID: 1660754.
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    436. Relative efficacy of spinal alpha-2 agonists, dexmedetomidine, clonidine and ST-91, determined in vivo by using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, an irreversible antagonist. J Pharmacol Exp Ther. 1991 Aug; 258(2):438-46. Takano Y, Yaksh TL. PMID: 1678011.
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    437. Characteristics of dose-dependent antagonism by beta-funaltrexamine of the antinociceptive effects of intrathecal mu agonists. J Pharmacol Exp Ther. 1991 Aug; 258(2):544-50. Mjanger E, Yaksh TL. PMID: 1650833.
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    438. The antinociceptive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relationship. J Pharmacol Exp Ther. 1991 Jul 01; 258(1):243-8. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Hua XY, Boublik JH, Spicer MA, Rivier JE, Brown MR, Yaksh TL. PMID: 1677040.
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    439. Effects of [N-(L-(1-carboxy-2-phenyl)ethyl]-L-phenylalanyl-beta-alanine (SCH32615), a neutral endopeptidase (enkephalinase) inhibitor, on levels of enkephalin, encrypted enkephalins and substance P in cerebrospinal fluid and plasma of primates. J Pharmacol Exp Ther. 1991 Mar; 256(3):1033-41. Yaksh TL, Sabbe MB, Lucas D, Mjanger E, Chipkin RE. PMID: 1706428.
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    440. Nicotinic- and muscarinic-evoked release of canine adrenal catecholamines and peptides. Am J Physiol. 1991 Mar; 260(3 Pt 2):R589-99. Chritton SL, Dousa MK, Yaksh TL, Tyce GM. PMID: 2001009.
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    441. Effects of a fish oil diet on pigs' cardiopulmonary response to bacteremia. JPEN J Parenter Enteral Nutr. 1991 Mar-Apr; 15(2):152-8. Murray MJ, Svingen BA, Holman RT, Yaksh TL. PMID: 1904949.
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    442. Leakage of fluid after epidural injection. Pain. 1991 Mar; 44(3):325. Yaksh TL. PMID: 2052401.
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    443. Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur J Pharmacol. 1991 Jan 10; 192(2):221-5. Fisher B, Zornow MH, Yaksh TL, Peterson BM. PMID: 1674472.
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    444. Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: antinociception in the absence of motor dysfunction. Life Sci. 1991; 49(26):1955-63. Yamamoto T, Yaksh TL. PMID: 1721102.
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    445. The utility of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs. Life Sci. 1991; 48(7):623-33. Yaksh TL, Jang JD, Nishiuchi Y, Braun KP, Ro SG, Goodman M. PMID: 1703620.
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    446. Pharmacology of intrathecal adrenergic agonists: cardiovascular and nociceptive reflexes in halothane-anesthetized rats. Anesthesiology. 1990 Dec; 73(6):1198-207. Nagasaka H, Yaksh TL. PMID: 1978989.
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    447. Differential cross-tolerance between intrathecal morphine and sufentanil in the rat. Anesthesiology. 1990 Dec; 73(6):1141-7. Sosnowski M, Yaksh TL. PMID: 1978988.
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    448. Release in vivo of Met-enkephalin and encrypted forms of Met-enkephalin from brain and spinal cord of the anesthetized cat. Peptides. 1990 Nov-Dec; 11(6):1119-25. Lucas D, Yaksh TL. PMID: 2087436.
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    449. Distribution of galanin-like immunoreactivity in the pig, rat and human central nervous system. Peptides. 1990 Nov-Dec; 11(6):1217-23. Michener SR, Aimone LD, Yaksh TL, Go VL. PMID: 1708138.
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    450. Demonstration of intrathecal and systemic morphine and ST-91 effects on fed canine upper gut motility. Dig Dis Sci. 1990 Oct; 35(10):1249-56. Thomforde GM, Malagelada JR, Camilleri M, Yaksh TL. PMID: 1976496.
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    451. Alpha-chloralose anesthesia inhibits the somato-sympathetic reflex response in cats more effectively than halothane. Zentralbl Veterinarmed A. 1990 Oct; 37(9):669-75. Gaumann DM, Yaksh TL. PMID: 2127972.
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    452. Effects of intrathecal morphine, clonidine, and midazolam on the somato-sympathoadrenal reflex response in halothane-anesthetized cats. Anesthesiology. 1990 Sep; 73(3):425-32. Gaumann DM, Yaksh TL, Tyce GM. PMID: 2393126.
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    453. Cryptic Met-enkephalin in adrenal and portal vein during splanchnic artery occlusion shock in cats. Neurosci Lett. 1990 Aug 24; 116(3):387-92. Gaumann DM, Yaksh TL, Lucas DL. PMID: 2243619.
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    454. Interaction of intrathecal morphine and ST-91 on antinociception in the rat: dose-response analysis, antagonism and clearance. J Pharmacol Exp Ther. 1990 Aug; 254(2):383-92. Monasky MS, Zinsmeister AR, Stevens CW, Yaksh TL. PMID: 1974633.
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    455. Distribution of neuropeptide Y in the spinal cords of cat, dog, rat, man and pig. Regul Pept. 1990 Jul 30; 29(2-3):81-92. Roddy DR, Yaksh TL, Aimone LD, Go VL. PMID: 2217906.
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    456. The antinociceptive effects of SCH-32615, a neutral endopeptidase (enkephalinase) inhibitor, microinjected into the periaqueductal, ventral medulla and amygdala. Brain Res. 1990 Jun 18; 520(1-2):123-30. al-Rodhan N, Chipkin R, Yaksh TL. PMID: 2207626.
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    457. The antinociceptive effects of intrathecally administered SCH32615, an enkephalinase inhibitor in the rat. Brain Res. 1990 May 07; 515(1-2):143-8. Oshita S, Yaksh TL, Chipkin R. PMID: 2357551.
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    458. The role of spinal and brainstem adenosine receptors in the modulation of the volume-evoked micturition reflex in the unanesthetized rat. Brain Res. 1990 May 07; 515(1-2):207-13. Sosnowski M, Yaksh TL. PMID: 2357559.
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    459. Intrathecal morphine and bupivacaine in the rat; analgesic synergy without augmentation of motor dysfunction or hypotension. Can J Anaesth. 1990 May; 37(4 Pt 2):S49. Penning JP, Nagasaka H, Yaksh TL. PMID: 2361296.
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    460. The analgesic interaction between intrathecal morphine, lidocaine and bupivacaine in the rat. Can J Anaesth. 1990 May; 37(4 Pt 2):S48. Penning JP, Yaksh TL. PMID: 2361295.
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    461. Interaction of midazolam and morphine in the spinal cord of the rat. Neuropharmacology. 1990 Apr; 29(4):359-64. Yanez A, Sabbe MB, Stevens CW, Yaksh TL. PMID: 2160622.
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    462. The antiseizure activity of dihydropyridine calcium channel antagonists in the conscious rat. J Pharmacol Exp Ther. 1990 Mar; 252(3):1150-5. Morón MA, Stevens CW, Yaksh TL. PMID: 2319465.
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    463. Measurement of lumbar CSF levels of met-enkephalin, encrypted met-enkephalin, and neuropeptide Y in normal patients and in patients with Parkinson's disease before and after autologous transplantation of adrenal medulla into the caudate nucleus. J Lab Clin Med. 1990 Mar; 115(3):346-51. Yaksh TL, Carmichael SW, Stoddard SL, Tyce GM, Kelly PJ, Lucas D, van Heerden JA, Ahlskog JE, Byer DE. PMID: 2313164.
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    464. Sites in the brain at which cholecystokinin octapeptide (CCK-8) acts to suppress feeding in rats: a mapping study. Neuropharmacology. 1990 Feb; 29(2):109-18. Schick RR, Harty GJ, Yaksh TL, Go VL. PMID: 2330072.
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    465. Long-term pain relief produced by intrathecal morphine infusion in 53 patients. J Neurosurg. 1990 Feb; 72(2):200-9. Onofrio BM, Yaksh TL. PMID: 1688618.
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    466. Systematic studies on the effects of the NMDA receptor antagonist MK-801 on cerebral blood flow and responsivity, EEG, and blood-brain barrier following complete reversible cerebral ischemia. J Cereb Blood Flow Metab. 1990 Jan; 10(1):77-88. Stevens MK, Yaksh TL. PMID: 2153692.
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    467. Epidural and intrathecal administration of sufentanil, alfentanil and morphine in the dog: a comparison of analgesic effects and the development of tolerance. NIDA Res Monogr. 1990; 105:560. Tiseo PJ, Sabbe MB, Yaksh TL. PMID: 1831544.
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    468. The secretion of catecholamines, chromogranin A and neuropeptide Y from the adrenal medulla of the cat via the adrenolumbar vein and thoracic duct: different anatomic routes based on size. Neuroscience. 1990; 34(2):433-40. Carmichael SW, Stoddard SL, O'Connor DT, Yaksh TL, Tyce GM. PMID: 2333152.
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    469. The spinal pharmacology of urinary function: studies on urinary continence in the unanaesthetized rat. Ciba Found Symp. 1990; 151:91-104; discussion 104-9. Tiseo PJ, Yaksh TL. PMID: 1699710.
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