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Tony Yaksh

Title(s)Recall Faculty, Anesthesiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    B.S.Georgia Institute of Technology
    M.S.University of Georgia
    Ph.D.Purdue University
    Collapse Awards and Honors
    1995American Society of Anesthesiology (ASA) Award for Excellence in Research;
    1996Emmanuel Papper Lecturer, Columbia Presbyterian Hospital
    1998Joris De Castro Memorial Lecture - Belgian Society of Anaesthesia and Reanimation
    1998American Academy of Pain Medicine, Award for Outstanding Contributions to Pain Medicine
    1999UCSD Chancellor’s Associates Faculty Excellence Award in Research
    1999American Academy of Pain Management, The John Liebeskind Award for Pain Research
    2000Swedish Society of Medicine, Torsten Gordh lecturer
    2001New York Society of Anesthesiologists Rovenstine Lecturer
    2007Javitz Award in Neuroscience; National Institute of Neurological, Communicative Diseases and Stroke
    2007Schueler Distinguished Lecturer award, Tulane University
    2007Seldon Memorial Lecturer award, International Anesthesia Research Society
    2007German Promotion Award for Pain Research and Therapy, German Pain Association
    2008ohn J. Bonica Distinguished Lecturer, International Association for the Study of Pain
    2012Presidential Commendation, World Institute of Pain
    2015Lifetime achievement award (North American Neuromodulation Society - NANS)
    2017Spain Distinguished Service Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Pre-clinical evaluation of DT-001, a small molecule antagonist of MD2-TLR4 for utility in the treatment of pain.
    NIH R41NS113717Sep 30, 2019 - Aug 31, 2021
    Role: Principal Investigator
    AIBP and regulation of neuropathic pain
    NIH R01NS102432May 1, 2019 - May 31, 2022
    Role: Co-Principal Investigator
    New Approach to Atopic Dermatitis
    NIH R43AR072546Sep 1, 2018 - Aug 31, 2021
    Role: Co-Principal Investigator
    Reversal of preexisting neuropathic pain by spinal delivery of AIBP
    NIH R33NS104769Aug 1, 2018 - Jul 31, 2021
    Role: Co-Principal Investigator
    Reversal of preexisting neuropathic pain by spinal delivery of AIBP
    NIH R21NS104769Aug 1, 2018 - Jul 31, 2020
    Role: Co-Principal Investigator
    Sex, Stress and Immunity in the Acute to Chronic Pain Transition
    NIH R01NS099338Jul 1, 2017 - Nov 30, 2021
    Role: Principal Investigator
    Construction and Analysis of BoNT derivatives as Pain Specific Inhibitors
    NIH R21AI113580Aug 7, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Discovery of novel small molecule analgesics
    NIH R41NS086244May 15, 2014 - Dec 31, 2015
    Role: Principal Investigator
    Myelin Autoantigens in Neuropathic Pain
    NIH R01DE022757Jul 30, 2012 - Aug 31, 2023
    Role: Principal Investigator
    The role of selective brain penetrating GRPR antagonists in pruritis.
    NIH R21NS077348Sep 30, 2011 - Dec 30, 2013
    Role: Principal Investigator
    Pain Mechanisms and the Development of Analgesics
    NIH R13DA021484Mar 1, 2006 - Feb 28, 2007
    Role: Principal Investigator
    Characterization of Toxicity with Spinal Opiates
    NIH R01DA015353Jul 1, 2002 - Jul 31, 2006
    Role: Principal Investigator
    Spinal Galanin and its Receptors in Pain Processing
    NIH R01NS041954Jun 1, 2002 - May 31, 2006
    Role: Principal Investigator
    Neurobiology of Pain
    NIH T32NS007407Jul 1, 1997 - Jun 30, 2007
    Role: Principal Investigator
    PRECLINICAL TOXICOLOGY STUDIES OF NMDA ANTAGONISTS
    NIH R01NS033846Aug 1, 1994 - Jul 31, 1998
    Role: Principal Investigator
    NEW MODALITIES FOR TREATMENT OF PAIN AND DRUG ABUSE
    NIH P01DA006284Sep 30, 1989 - Mar 31, 2016
    Role: Co-Investigator
    Pain Evoked Release of Amino Acids and Prostanoids
    NIH R37NS016541Sep 1, 1988 - Feb 28, 2013
    Role: Principal Investigator
    PEPTIDE RELEASE FROM PERIPHERAL TERMINALS OF AFFERENTS
    NIH R01AI026249Apr 1, 1988 - Aug 31, 1988
    Role: Principal Investigator
    The Pharmacology of Spinal Analgesics
    NIH R01DA002110Jul 1, 1983 - Aug 31, 1988
    Role: Principal Investigator
    SPINAL PHARMACOLOGY OF BLADDER FUNCTION
    NIH R01NS019650Jul 1, 1983 - Jun 30, 1986
    Role: Principal Investigator
    PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    NIH R01NS016541Jul 1, 1980 - Dec 31, 2005
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Nov 30, 1991
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Unintended consequences of COVID-19 safety measures on patients with chronic knee pain forced to defer joint replacement surgery. Pain Rep. 2020 Nov-Dec; 5(6):e855. Cisternas AF, Ramachandran R, Yaksh TL, Nahama A. PMID: 33134751.
      View in: PubMed   Mentions:
    2. The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling. Sci Rep. 2020 09 24; 10(1):15596. Gonçalves Dos Santos G, Jimenéz-Andrade JM, Woller SA, Muñoz-Islas E, Ramírez-Rosas MB, Ohashi N, Ferreira Catroli G, Fujita Y, Yaksh TL, Corr M. PMID: 32973194.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Topical Application of ASN008, a Permanently Charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset, and Long Duration of Action in a Mouse Model of Pruritus. J Pharmacol Exp Ther. 2020 09; 374(3):521-528. Ramachandran R, Thompson SK, Malkmus S, Mieda T, Lin JH, Gupta S, Yaksh TL. PMID: 32616515.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice. J Biol Chem. 2020 07 31; 295(31):10807-10821. Chernov AV, Hullugundi SK, Eddinger KA, Dolkas J, Remacle AG, Angert M, James BP, Yaksh TL, Strongin AY, Shubayev VI. PMID: 32532796.
      View in: PubMed   Mentions:    Fields:    
    5. Pharmacodynamics of intrathecal and epidural fadolmidine, an a2-adrenoceptor agonist, after bolus and infusion in dogs-comparison with clonidine. Naunyn Schmiedebergs Arch Pharmacol. 2020 08; 393(8):1459-1473. Leino T, Yaksh T, Horais K, Haapalinna A. PMID: 32179953.
      View in: PubMed   Mentions:    Fields:    
    6. Neuraxial Cytokines in Pain States. Front Immunol. 2019; 10:3061. Gonçalves Dos Santos G, Delay L, Yaksh TL, Corr M. PMID: 32047493.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Lipid rafts in glial cells: role in neuroinflammation and pain processing. J Lipid Res. 2020 05; 61(5):655-666. Miller YI, Navia-Pelaez JM, Corr M, Yaksh TL. PMID: 31862695.
      View in: PubMed   Mentions: 3     Fields:    
    8. Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety. Pain. 2019 10; 160(10):2210-2220. Schmelz M, Mantyh P, Malfait AM, Farrar J, Yaksh T, Tive L, Viktrup L. PMID: 31145219.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    9. Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling. Anesthesiology. 2019 07; 131(1):132-147. Yaksh TL, Eddinger KA, Kokubu S, Wang Z, DiNardo A, Ramachandran R, Zhu Y, He Y, Weren F, Quang D, Malkmus SA, Lansu K, Kroeze WK, Eliceiri B, Steinauer JJ, Schiller PW, Gmeiner P, Page LM, Hildebrand KR. PMID: 31225809.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Characterization of Effect of Repeated Bolus or Continuous Intrathecal Infusion of Morphine on Spinal Mass Formation in the Dog. Neuromodulation. 2019 Oct; 22(7):790-798. Hildebrand KR, Page LM, Billstrom TM, Steinauer JJ, Eddinger KA, Arjomand S, Yaksh TL. PMID: 31124198.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. Unilateral Epidural Targeting of Resiniferatoxin Induces Bilateral Neurolysis of Spinal Nociceptive Afferents. Pain Med. 2019 05 01; 20(5):897-906. Unger MD, Pleticha J, Steinauer J, Kanwar R, Diehn F, LaVallee KT, Banck MS, Jones B, Yaksh TL, Maus TP, Beutler AS. PMID: 30590777.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    12. Characterization of Analgesic Actions of the Chronic Intrathecal Infusion of H-Dmt-D-Arg-Phe-Lys-NH2 in Rat. Neuromodulation. 2019 Oct; 22(7):781-789. Kokubu S, Eddinger KA, Yamaguchi S, Huerta-Esquivel LL, Schiller PW, Yaksh TL. PMID: 30794333.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. Letter to Editor re: "Unique Intradural Inflammatory Mass Containing Precipitated Morphine" by Kim et al. Pain Pract. 2019 04; 19(4):456. Yaksh TL. PMID: 30614650.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery. Scand J Pain. 2019 01 28; 19(1):193-206. Kokubu S, Eddinger KA, Nguyen TM, Huerta-Esquivel LL, Yamaguchi S, Schiller PW, Yaksh TL. PMID: 30367811.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    15. Role of Toll-like receptor 4 signaling in mast cell-mediated migraine pain pathway. Mol Pain. 2019 Jan-Dec; 15:1744806919867842. Ramachandran R, Wang Z, Saavedra C, DiNardo A, Corr M, Powell SB, Yaksh TL. PMID: 31342858.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Botulinum toxin blocks mast cells and prevents rosacea like inflammation. J Dermatol Sci. 2019 Jan; 93(1):58-64. Choi JE, Werbel T, Wang Z, Wu CC, Yaksh TL, Di Nardo A. PMID: 30658871.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Spinal Exparel®-an extended duration of preclinical study needed. Br J Anaesth. 2019 03; 122(3):298-300. Eisenach JC, Yaksh TL. PMID: 30770045.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    18. Development of New Analgesics: An Answer to Opioid Epidemic. Trends Pharmacol Sci. 2018 12; 39(12):1000-1002. Yaksh TL, Hunt MA, Dos Santos GG. PMID: 30454767.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    19. Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats. Pain. 2018 Dec; 159(12):2620-2629. Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. PMID: 30130298.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Neuraxial TNF and IFN-beta co-modulate persistent allodynia in arthritic mice. Brain Behav Immun. 2019 02; 76:151-158. Woller SA, Ocheltree C, Wong SY, Bui A, Fujita Y, Gonçalves Dos Santos G, Yaksh TL, Corr M. PMID: 30465880.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    21. Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome. Mol Pain. 2018 Jan-Dec; 14:1744806918815005. Shubayev VI, Strongin AY, Yaksh TL. PMID: 30392459.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    22. Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states. Pain. 2018 Oct; 159(10):1908-1915. Bruno K, Woller SA, Miller YI, Yaksh TL, Wallace M, Beaton G, Chakravarthy K. PMID: 29889119.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    23. Transition to chronic pain: opportunities for novel therapeutics. Nat Rev Neurosci. 2018 07; 19(7):383-384. Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH. PMID: 29765159.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    24. Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States. Cell Rep. 2018 05 29; 23(9):2667-2677. Woller SA, Choi SH, An EJ, Low H, Schneider DA, Ramachandran R, Kim J, Bae YS, Sviridov D, Corr M, Yaksh TL, Miller YI. PMID: 29847797.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    25. Complexity of systems and actions underlying neurogenic inflammation. Semin Immunopathol. 2018 05; 40(3):225-228. Yaksh TL, Di Nardo A. PMID: 29779134.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    26. Rapid continuous 3D printing of customizable peripheral nerve guidance conduits. Mater Today (Kidlington). 2018 Nov; 21(9):951-959. Zhu W, Tringale KR, Woller SA, You S, Johnson S, Shen H, Schimelman J, Whitney M, Steinauer J, Xu W, Yaksh TL, Nguyen QT, Chen S. PMID: 31156331.
      View in: PubMed   Mentions:
    27. A Study and Review of Effects of Botulinum Toxins on Mast Cell Dependent and Independent Pruritus. Toxins (Basel). 2018 03 23; 10(4). Ramachandran R, Marino MJ, Paul S, Wang Z, Mascarenhas NL, Pellett S, Johnson EA, DiNardo A, Yaksh TL. PMID: 29570628.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    28. Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation. Semin Immunopathol. 2018 May; 40(3):237-247. Sorkin LS, Eddinger KA, Woller SA, Yaksh TL. PMID: 29423889.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    29. An overview of pathways encoding nociception. Clin Exp Rheumatol. 2018 Jan-Feb; 36(1):172. Woller SA, Eddinger KA, Corr M, Yaksh TL. PMID: 29461960.
      View in: PubMed   Mentions: 4     Fields:    
    30. Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular. Int J Toxicol. 2018 Jan/Feb; 37(1):4-27. Emami A, Tepper J, Short B, Yaksh TL, Bendele AM, Ramani T, Cisternas AF, Chang JH, Mellon RD. PMID: 29264927.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. Target engagement and histopathology of neuraxial resiniferatoxin in dog. Vet Anaesth Analg. 2018 Mar; 45(2):212-226. Hockman TM, Cisternas AF, Jones B, Butt MT, Osborn KG, Steinauer JJ, Malkmus SA, Yaksh TL. PMID: 29361418.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    32. Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics. Anesth Analg. 2017 11; 125(5):1714-1732. Knezevic NN, Yekkirala A, Yaksh TL. PMID: 29049116.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    33. Effects of opioid and nonopioid analgesics on canine wheal formation and cultured human mast cell degranulation. Toxicol Appl Pharmacol. 2018 01 01; 338:54-64. Schmidt-Rondon E, Wang Z, Malkmus SA, Di Nardo A, Hildebrand K, Page L, Yaksh TL. PMID: 29111148.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    34. An overview of pathways encoding nociception. Clin Exp Rheumatol. 2017 Sep-Oct; 35 Suppl 107(5):40-46. Woller SA, Eddinger KA, Corr M, Yaksh TL. PMID: 28967373.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    35. Editor's Highlight: Formulation and Toxicology Evaluation of the Intrathecal AYX1 DNA-Decoy in Sprague Dawley Rats. Toxicol Sci. 2017 09 01; 159(1):76-85. Mamet J, Yeomans DC, Yaksh TL, Manning DC, Harris S. PMID: 28903493.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    36. Modeling Spinal Intrathecal Drug Distribution: The Challenge of Defining and Predicting Cerebrospinal Fluid Dynamics. Anesth Analg. 2017 05; 124(5):1403-1406. Bert RJ, Hayek SM, Yaksh TL. PMID: 28426585.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 10; 18(10):1184-1196. Yaksh TL, Schwarcz R, Snodgrass HR. PMID: 28428091.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    38. Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model. Scand J Pain. 2017 07; 16:1-9. Rijsdijk M, Agalave NM, van Wijck AJM, Kalkman CJ, Ramachandran R, Baharpoor A, Svensson CI, Yaksh TL. PMID: 28850381.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    39. The Polyanalgesic Consensus Conference (PACC): Recommendations for Intrathecal Drug Delivery: Guidance for Improving Safety and Mitigating Risks. Neuromodulation. 2017 Feb; 20(2):155-176. Deer TR, Pope JE, Hayek SM, Lamer TJ, Veizi IE, Erdek M, Wallace MS, Grider JS, Levy RM, Prager J, Rosen SM, Saulino M, Yaksh TL, De Andrés JA, Abejon Gonzalez D, Vesper J, Schu S, Simpson B, Mekhail N. PMID: 28042914.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    40. The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines. Neuromodulation. 2017 02; 20(2):96-132. Deer TR, Pope JE, Hayek SM, Bux A, Buchser E, Eldabe S, De Andrés JA, Erdek M, Patin D, Grider JS, Doleys DM, Jacobs MS, Yaksh TL, Poree L, Wallace MS, Prager J, Rauck R, DeLeon O, Diwan S, Falowski SM, Gazelka HM, Kim P, Leong M, Levy RM, McDowell G, McRoberts P, Naidu R, Narouze S, Perruchoud C, Rosen SM, Rosenberg WS, Saulino M, Staats P, Stearns LJ, Willis D, Krames E, Huntoon M, Mekhail N. PMID: 28042904.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    41. Pharmacology, pharmacokinetics, and metabolism of the DNA-decoy AYX1 for the prevention of acute and chronic post-surgical pain. Mol Pain. 2017 01; 13:1744806917703112. Mamet J, Harris S, Klukinov M, Yeomans DC, Donahue RR, Taylor BK, Eddinger K, Yaksh T, Manning DC. PMID: 28394696.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    42. Current and Future Issues in the Development of Spinal Agents for the Management of Pain. Curr Neuropharmacol. 2017; 15(2):232-259. Yaksh TL, Fisher CJ, Hockman TM, Wiese AJ. PMID: 26861470.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    43. Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain. Brain Behav Immun. 2017 Feb; 60:282-292. Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi SK, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev VI. PMID: 27833045.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    44. Ethical Concerns Regarding Human Study. CNS Neurosci Ther. 2016 10; 22(10):866. Eisenach JC, Yaksh TL. PMID: 27577599.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Primary Hydromorphone-Related Intrathecal Catheter Tip Granulomas: Is There a Role for Dose and Concentration? Neuromodulation. 2016 Oct; 19(7):760-769. Veizi IE, Hayek SM, Hanes M, Galica R, Katta S, Yaksh T. PMID: 27505059.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    46. Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation. Anesthesiology. 2016 08; 125(2):378-94. Eddinger KA, Rondon ES, Shubayev VI, Grafe MR, Scadeng M, Hildebrand KR, Page LM, Malkmus SA, Steinauer JJ, Yaksh TL. PMID: 27272672.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    47. Role of myelin auto-antigens in pain: a female connection. Neural Regen Res. 2016 Jun; 11(6):890-1. Shubayev VI, Strongin AY, Yaksh TL. PMID: 27482203.
      View in: PubMed   Mentions:
    48. Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt. Eur J Neurosci. 2016 07; 44(1):1714-22. Sikandar S, Gustavsson Y, Marino MJ, Dickenson AH, Yaksh TL, Sorkin LS, Ramachandran R. PMID: 27108664.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid. Cannabis Cannabinoid Res. 2016; 1(1):102-112. Merrick J, Lane B, Sebree T, Yaksh T, O'Neill C, Banks SL. PMID: 28861485.
      View in: PubMed   Mentions:
    50. Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state. Brain Behav Immun. 2016 08; 56:271-80. Woller SA, Ravula SB, Tucci FC, Beaton G, Corr M, Isseroff RR, Soulika AM, Chigbrow M, Eddinger KA, Yaksh TL. PMID: 27044335.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    51. Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia. Brain Behav Immun. 2016 Aug; 56:378-89. Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev VI. PMID: 26970355.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    52. The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annu Rev Pharmacol Toxicol. 2016; 56:511-33. Podvin S, Yaksh T, Hook V. PMID: 26738478.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    53. Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models. Scand J Pain. 2016 01; 10:90-102. Rijsdijk M, Svensson CI, Wijck AJ, Kalkman CJ, Yaksh TL. PMID: 28361779.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    54. Current status and future directions of botulinum neurotoxins for targeting pain processing. Toxins (Basel). 2015 Nov 04; 7(11):4519-63. Pellett S, Yaksh TL, Ramachandran R. PMID: 26556371.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    55. The effects of intraplantar and intrathecal botulinum toxin type B on tactile allodynia in mono and polyneuropathy in the mouse. Anesth Analg. 2015 Jul; 121(1):229-38. Park HJ, Marino MJ, Rondon ES, Xu Q, Yaksh TL. PMID: 26039418.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    56. The search for novel analgesics: targets and mechanisms. F1000Prime Rep. 2015; 7:56. Yaksh TL, Woller SA, Ramachandran R, Sorkin LS. PMID: 26097729.
      View in: PubMed   Mentions:
    57. Botulinum toxin in migraine: Role of transport in trigemino-somatic and trigemino-vascular afferents. Neurobiol Dis. 2015 Jul; 79:111-22. Ramachandran R, Lam C, Yaksh TL. PMID: 25958249.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    58. Therapeutic use of botulinum toxin in migraine: mechanisms of action. Br J Pharmacol. 2014 Sep; 171(18):4177-92. PMID: 24819339.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    59. The effects of glucocorticoids on neuropathic pain: a review with emphasis on intrathecal methylprednisolone acetate delivery. Anesth Analg. 2014 May; 118(5):1097-112. PMID: 24781577.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
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    109. Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase. Anesth Analg. 2010 Aug; 111(2):554-60. Matsui T, Svensson CI, Hirata Y, Mizobata K, Hua XY, Yaksh TL. PMID: 20610553.
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    110. Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome. Anesthesiology. 2010 Jul; 113(1):147-59. Walker SM, Westin BD, Deumens R, Grafe M, Yaksh TL. PMID: 20526188.
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    114. Role of spinal cyclooxygenase in human postoperative and chronic pain. Anesthesiology. 2010 May; 112(5):1225-33. Eisenach JC, Curry R, Rauck R, Pan P, Yaksh TL. PMID: 20395820.
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    115. Effects of intrathecal ketorolac on human experimental pain. Anesthesiology. 2010 May; 112(5):1216-24. Eisenach JC, Curry R, Tong C, Houle TT, Yaksh TL. PMID: 20395821.
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    116. Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs. Cell Transplant. 2010; 19(9):1103-22. Usvald D, Vodicka P, Hlucilova J, Prochazka R, Motlik J, Kuchorova K, Johe K, Marsala S, Scadeng M, Kakinohana O, Navarro R, Santa M, Hefferan MP, Yaksh TL, Marsala M. PMID: 20412634.
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    121. [Vacuoles: a hollow threat?]. Can J Anaesth. 2010 Mar; 57(3):195-200. Yaksh TL. PMID: 20054677.
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    123. Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. Neurosci Lett. 2010 Feb 05; 470(1):6-9. Park P, Schachter S, Yaksh T. PMID: 20026382.
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    124. Behavioral models of pain states evoked by physical injury to the peripheral nerve. Neurotherapeutics. 2009 Oct; 6(4):609-19. Sorkin LS, Yaksh TL. PMID: 19789066.
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    125. Randomized, double-blind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica. Anesthesiology. 2009 May; 110(5):1116-26. Cohen SP, Bogduk N, Dragovich A, Buckenmaier CC, Griffith S, Kurihara C, Raymond J, Richter PJ, Williams N, Yaksh TL. PMID: 19387178.
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    127. Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology. 2009 Apr; 136(4):1339-48, e1-2. Bradesi S, Svensson CI, Steinauer J, Pothoulakis C, Yaksh TL, Mayer EA. PMID: 19249394.
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    128. Spinal antinociceptive action of loperamide is mediated by opioid receptors in the formalin test in rats. Neurosci Lett. 2008 Dec 31; 448(3):260-2. Ray SB, Yaksh TL. PMID: 18973791.
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    129. Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain. Pharmacol Biochem Behav. 2008 Oct; 90(4):664-75. Svensson CI, Medicherla S, Malkmus S, Jiang Y, Ma JY, Kerr I, Brainin-Mattos J, Powell HC, Luo ZD, Chakravarty S, Dugar S, Higgins LS, Protter AA, Yaksh TL. PMID: 18584857.
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    130. Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12599-604. Ilieva HS, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW. PMID: 18719118.
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    132. Acetaminophen prevents hyperalgesia in central pain cascade. Neurosci Lett. 2008 Sep 05; 442(1):50-3. Crawley B, Saito O, Malkmus S, Fitzsimmons B, Hua XY, Yaksh TL. PMID: 18601979.
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    133. The effect of acupuncture duration on analgesia and peripheral sensory thresholds. BMC Complement Altern Med. 2008 May 01; 8:18. Leung AY, Kim SJ, Schulteis G, Yaksh T. PMID: 18452622.
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    135. Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. Neuropharmacology. 2008 Feb; 54(2):269-79. Khan IM, Wart CV, Singletary EA, Stanislaus S, Deerinck T, Yaksh TL, Printz MP. PMID: 18037142.
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    145. The electrophysiology of de qi sensations. J Altern Complement Med. 2006 Oct; 12(8):743-50. Leung AY, Park J, Schulteis G, Duann JR, Yaksh T. PMID: 17034280.
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    146. Time course and role of morphine dose and concentration in intrathecal granuloma formation in dogs: a combined magnetic resonance imaging and histopathology investigation. Anesthesiology. 2006 Sep; 105(3):581-9. Allen JW, Horais KA, Tozier NA, Wegner K, Corbeil JA, Mattrey RF, Rossi SS, Yaksh TL. PMID: 16931993.
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    149. Covariance among age, spinal p38 MAP kinase activation and allodynia. J Pain. 2006 May; 7(5):337-45. Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin LS. PMID: 16632323.
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    150. Cancer-related bone pain is attenuated by a systemically available delta-opioid receptor agonist. Pain. 2006 May; 122(1-2):174-81. Brainin-Mattos J, Smith ND, Malkmus S, Rew Y, Goodman M, Taulane J, Yaksh TL. PMID: 16545911.
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    151. Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs. Toxicol Sci. 2006 May; 91(1):286-98. Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL. PMID: 16500924.
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    152. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur J Neurosci. 2006 Feb; 23(3):627-36. Shi TJ, Hua XY, Lu X, Malkmus S, Kinney J, Holmberg K, Wirz S, Ceccatelli S, Yaksh T, Bartfai T, Hökfelt T. PMID: 16487144.
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    153. Calcium channels as therapeutic targets in neuropathic pain. J Pain. 2006 Jan; 7(1 Suppl 1):S13-30. Yaksh TL. PMID: 16426997.
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    154. Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia. Eur J Neurosci. 2005 Nov; 22(10):2431-40. Hua XY, Svensson CI, Matsui T, Fitzsimmons B, Yaksh TL, Webb M. PMID: 16307586.
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    155. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. J Pharmacol Exp Ther. 2006 Jan; 316(1):466-75. Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA. PMID: 16203828.
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    156. Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. Neuropeptides. 2005 Oct; 39(5):485-94. Svensson CI, Hua XY, Powell HC, Lai J, Porreca F, Yaksh TL. PMID: 16176831.
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    157. Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain. 2005 Nov; 118(1-2):112-24. Nielsen CK, Lewis RJ, Alewood D, Drinkwater R, Palant E, Patterson M, Yaksh TL, McCumber D, Smith MT. PMID: 16154696.
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    158. Unexpected pain in a dog: aberration or worthy of a citation? Agree to disagree. Lab Anim (NY). 2005 Sep; 34(8):19. Torchia M, Yaksh T. PMID: 16136070.
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    159. The effect of Ting point (tendinomuscular meridians) electroacupuncture on thermal pain: a model for studying the neuronal mechanism of acupuncture analgesia. J Altern Complement Med. 2005 Aug; 11(4):653-61. Leung A, Khadivi B, Duann JR, Cho ZH, Yaksh T. PMID: 16131289.
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    160. Qualitative and quantitative characterization of the thermal grill. Pain. 2005 Jul; 116(1-2):26-32. Leung AY, Wallace MS, Schulteis G, Yaksh TL. PMID: 15935558.
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    161. Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence. J Pharmacol Exp Ther. 2005 Sep; 314(3):1362-9. Gu G, Kondo I, Hua XY, Yaksh TL. PMID: 15908510.
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    162. Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. J Neurosci. 2005 Apr 06; 25(14):3651-60. Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL. PMID: 15814796.
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    163. Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. Br J Pharmacol. 2005 Apr; 144(7):940-52. Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. PMID: 15685208.
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    164. Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. J Neurochem. 2005 Mar; 92(6):1508-20. Svensson CI, Fitzsimmons B, Azizi S, Powell HC, Hua XY, Yaksh TL. PMID: 15748168.
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    165. Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia. Eur J Neurosci. 2004 Nov; 20(9):2401-14. Marsala M, Kakinohana O, Yaksh TL, Tomori Z, Marsala S, Cizkova D. PMID: 15525281.
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    166. Ablation of primary afferent terminals reduces nicotinic receptor expression and the nociceptive responses to nicotinic agonists in the spinal cord. J Neurocytol. 2004 Sep; 33(5):543-56. Khan IM, Wennerholm M, Singletary E, Polston K, Zhang L, Deerinck T, Yaksh TL, Taylor P. PMID: 15906161.
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    167. A preclinical post laminectomy rat model mimics the human post laminectomy syndrome. J Neurosci Methods. 2004 Aug 30; 137(2):283-9. Massie JB, Huang B, Malkmus S, Yaksh TL, Kim CW, Garfin SR, Akeson WH. PMID: 15262072.
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    168. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10470-5. Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J. PMID: 15240875.
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    169. Intrathecal protease-activated receptor stimulation produces thermal hyperalgesia through spinal cyclooxygenase activity. J Pharmacol Exp Ther. 2004 Oct; 311(1):356-63. Koetzner L, Gregory JA, Yaksh TL. PMID: 15175421.
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    170. Preclinical insights into the implementation of intrathecal midazolam: a cautionary tale. Anesth Analg. 2004 Jun; 98(6):1509-11. Yaksh TL, Allen JW. PMID: 15155298.
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    171. The use of intrathecal midazolam in humans: a case study of process. Anesth Analg. 2004 Jun; 98(6):1536-45, table of contents. Yaksh TL, Allen JW. PMID: 15155302.
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    172. Intrathecal ketorolac in dogs and rats. Toxicol Sci. 2004 Aug; 80(2):322-34. Yaksh TL, Horais KA, Tozier N, Rathbun M, Richter P, Rossi S, Grafe M, Tong C, Meschter C, Cline JM, Eisenach J. PMID: 15141096.
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    173. Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia. J Neurosci. 2004 Mar 17; 24(11):2727-32. Ghilardi JR, Svensson CI, Rogers SD, Yaksh TL, Mantyh PW. PMID: 15028765.
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    174. Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. J Neurosci. 2004 Feb 11; 24(6):1451-8. Koetzner L, Hua XY, Lai J, Porreca F, Yaksh T. PMID: 14960618.
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    175. Intrathecal but not intravenous opioids release adenosine from the spinal cord. J Pain. 2004 Feb; 5(1):64-8. Eisenach JC, Hood DD, Curry R, Sawynok J, Yaksh TL, Li X. PMID: 14975380.
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    176. Tissue injury models of persistent nociception in rats. Methods Mol Med. 2004; 99:25-34. Allen JW, Yaksh TL. PMID: 15131326.
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    177. Intrathecal catheterization and drug delivery in the rat. Methods Mol Med. 2004; 99:109-21. Malkmus SA, Yaksh TL. PMID: 15131333.
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    178. Assessment of acute thermal nociception in laboratory animals. Methods Mol Med. 2004; 99:11-23. Allen JW, Yaksh TL. PMID: 15131325.
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    179. Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Exp Neurol. 2004 Jan; 185(1):160-8. Schäfers M, Marziniak M, Sorkin LS, Yaksh TL, Sommer C. PMID: 14697327.
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    180. Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways. J Comp Neurol. 2003 Dec 01; 467(1):44-59. Khan I, Osaka H, Stanislaus S, Calvo RM, Deerinck T, Yaksh TL, Taylor P. PMID: 14574679.
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    181. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther. 2004 Feb; 308(2):574-82. Hua XY, Hayes CS, Hofer A, Fitzsimmons B, Kilk K, Langel U, Bartfai T, Yaksh TL. PMID: 14610237.
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    182. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003 Sep; 86(6):1534-44. Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. PMID: 12950462.
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    183. Preclinical work leading to the development of spinal analgesia. Anesthesiology. 2003 Jul; 99(1):224-5. Yaksh TL. PMID: 12826864.
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    184. Chronically infused intrathecal morphine in dogs. Anesthesiology. 2003 Jul; 99(1):174-87. Yaksh TL, Horais KA, Tozier NA, Allen JW, Rathbun M, Rossi SS, Sommer C, Meschter C, Richter PJ, Hildebrand KR. PMID: 12826858.
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    185. A double-lumen intrathecal catheter for studies of modulation of spinal opiate tolerance. J Neurosci Methods. 2003 Jun 30; 126(2):165-73. Hayes CS, Mulkmus SA, Cizkova D, Yaksh TL, Hua XY. PMID: 12814841.
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    186. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosci. 2003 Jun 15; 23(12):5031-40. South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage FH, Yaksh TL, Woolf CJ, Heinemann SF, Inturrisi CE. PMID: 12832526.
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    187. Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia. Neuroreport. 2003 Jun 11; 14(8):1153-7. Svensson CI, Hua XY, Protter AA, Powell HC, Yaksh TL. PMID: 12821799.
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    188. Neuraxial morphine may trigger transient motor dysfunction after a noninjurious interval of spinal cord ischemia: a clinical and experimental study. Anesthesiology. 2003 Apr; 98(4):862-70. Kakinohana M, Marsala M, Carter C, Davison JK, Yaksh TL. PMID: 12657847.
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    189. Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci. 2003 Apr 01; 23(7):3028-38. Schäfers M, Lee DH, Brors D, Yaksh TL, Sorkin LS. PMID: 12684490.
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    190. Rapid quantification of the non-competitive NMDA antagonist MK-801 in canine cerebrospinal fluid and plasma by capillary gas chromatography-nitrogen phosphorus detection. J Pharm Biomed Anal. 2003 Feb 26; 31(2):243-50. Rossi S, Yaksh T. PMID: 12609663.
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    191. Systemic and spinal analgesic activity of a delta-opioid-selective lanthionine enkephalin analog. J Pharmacol Exp Ther. 2003 Feb; 304(2):827-32. Svensson CI, Rew Y, Malkmus S, Schiller PW, Taulane JP, Goodman M, Yaksh TL. PMID: 12538839.
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    192. Epidural ketamine in healthy children--what's the point? Anesth Analg. 2003 Feb; 96(2):626; author reply 626-7. Eisenach JC, Yaksh TL. PMID: 12538224.
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    193. Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats. Br J Pharmacol. 2003 Feb; 138(4):689-97. Ibuki T, Marsala M, Masuyama T, Yaksh TL. PMID: 12598423.
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    194. Effects of chronic intrathecal infusion of a partial differential opioid agonist in dogs. Toxicol Sci. 2003 Feb; 71(2):263-75. Horais K, Hruby V, Rossi S, Cizkova D, Meschter C, Dorr R, Yaksh TL. PMID: 12563112.
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    195. Inflammatory masses associated with intrathecal drug infusion: a review of preclinical evidence and human data. Pain Med. 2002 Dec; 3(4):300-12. Yaksh TL, Hassenbusch S, Burchiel K, Hildebrand KR, Page LM, Coffey RJ. PMID: 15099235.
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    196. Safety in numbers: how do we study toxicity of spinal analgesics? Anesthesiology. 2002 Nov; 97(5):1047-9. Eisenach JC, Yaksh TL. PMID: 12411784.
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    197. Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness. Physiol Genomics. 2002 Oct 29; 11(2):65-72. Khan IM, Singletary E, Alemayehu A, Stanislaus S, Printz MP, Yaksh TL, Taylor P. PMID: 12388796.
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    198. Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain. Pain. 2002 Oct; 99(3):397-406. Luger NM, Sabino MAC, Schwei MJ, Mach DB, Pomonis JD, Keyser CP, Rathbun M, Clohisy DR, Honore P, Yaksh TL, Mantyh PW. PMID: 12406514.
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    199. Phase I safety assessment of intrathecal ketorolac. Pain. 2002 Oct; 99(3):599-604. Eisenach JC, Curry R, Hood DD, Yaksh TL. PMID: 12406536.
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    200. Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury. Exp Brain Res. 2002 Dec; 147(4):456-63. Cizkova D, Marsala J, Lukacova N, Marsala M, Jergova S, Orendacova J, Yaksh TL. PMID: 12444477.
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    201. Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands. J Med Chem. 2002 Aug 15; 45(17):3746-54. Rew Y, Malkmus S, Svensson C, Yaksh TL, Chung NN, Schiller PW, Cassel JA, DeHaven RN, Taulane JP, Goodman M. PMID: 12166947.
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    202. Rapid quantification of the delta-opioid receptor selective enkephalin DPDPE in canine cerebrospinal fluid by liquid chromatography--mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 25; 772(1):73-9. Rossi S, Yaksh T. PMID: 12016017.
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    203. Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury. Anesth Analg. 2002 Apr; 94(4):968-74, table of contents. Nozaki-Taguchi N, Yaksh TL. PMID: 11916806.
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    204. Pharmacology of spinal glutamatergic receptors in post-thermal injury-evoked tactile allodynia and thermal hyperalgesia. Anesthesiology. 2002 Mar; 96(3):617-26. Nozaki-Taguchi N, Yaksh TL. PMID: 11873037.
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    205. Anterograde transport of tumor necrosis factor-alpha in the intact and injured rat sciatic nerve. J Neurosci. 2002 Jan 15; 22(2):536-45. Schäfers M, Geis C, Brors D, Yaksh TL, Sommer C. PMID: 11784800.
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    206. Future advances in pain pharmacology: what does the present say about the future? Proc West Pharmacol Soc. 2002; 45:211-8. Yaksh TL. PMID: 12434582.
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    207. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annu Rev Pharmacol Toxicol. 2002; 42:553-83. Svensson CI, Yaksh TL. PMID: 11807183.
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    208. Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia. J Clin Pharmacol. 2002 Jan; 42(1):70-80. Wallace MS, Ridgeway B, Leung A, Schulteis G, Yaksh TL. PMID: 11808827.
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    209. Effects of continuous lumbar intrathecal infusion of leptin in rats on weight regulation. Neuroscience. 2002; 110(4):703-10. Yaksh TL, Scott B, LeBel CL. PMID: 11934477.
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    210. The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. J Neurosci. 2001 Aug 15; 21(16):5847-53. Yaksh TL, Dirig DM, Conway CM, Svensson C, Luo ZD, Isakson PC. PMID: 11487607.
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    211. Vincristine-induced allodynia in the rat. Pain. 2001 Jul; 93(1):69-76. Nozaki-Taguchi N, Chaplan SR, Higuera ES, Ajakwe RC, Yaksh TL. PMID: 11406340.
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    212. An automated flinch detecting system for use in the formalin nociceptive bioassay. J Appl Physiol (1985). 2001 Jun; 90(6):2386-402. Yaksh TL, Ozaki G, McCumber D, Rathbun M, Svensson C, Malkmus S, Yaksh MC. PMID: 11356806.
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    213. Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion. Pain. 2000 Apr; 85(3):395-404. Granados-Soto V, Kalcheva I, Hua XY, Newton A, Yaksh TL. PMID: 10781912.
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    214. Regulation of spinal nociceptive processing: where we went when we wandered onto the path marked by the gate. Pain. 1999 Aug; Suppl 6:S149-52. Yaksh TL. PMID: 10491984.
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    215. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):7680-6. Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, Marsala M. PMID: 10393880.
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    216. Pharmacokinetics and efficacy of epidurally delivered sustained-release encapsulated morphine in dogs. Anesthesiology. 1999 May; 90(5):1402-12. Yaksh TL, Provencher JC, Rathbun ML, Kohn FR. PMID: 10319789.
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    217. Mechanism of action of nonsteroidal anti-inflammatory drugs. Cancer Invest. 1998; 16(7):509-27. Yaksh TL, Dirig DM, Malmberg AB. PMID: 9774958.
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    218. Computer-controlled lidocaine infusion for the evaluation of neuropathic pain after peripheral nerve injury. Pain. 1996 Jul; 66(1):69-77. Wallace MS, Dyck JB, Rossi SS, Yaksh TL. PMID: 8857633.
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    219. Differential right shifts in the dose-response curve for intrathecal morphine and sufentanil as a function of stimulus intensity. Pain. 1995 Sep; 62(3):321-8. Dirig DM, Yaksh TL. PMID: 8657432.
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    220. Effect of continuous intrathecal infusion of omega-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain. 1995 Jan; 60(1):83-90. Malmberg AB, Yaksh TL. PMID: 7715945.
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    221. Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. Pain. 1994 Sep; 58(3):413-420. Calcutt NA, Malmberg AB, Yamamoto T, Yaksh TL. PMID: 7838591.
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    222. Effects of colchicine applied to the peripheral nerve on the thermal hyperalgesia evoked with chronic nerve constriction. Pain. 1993 Nov; 55(2):227-33. Yamamoto T, Yaksh TL. PMID: 7508592.
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    223. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain. 1993 Sep; 54(3):291-300. Malmberg AB, Yaksh TL. PMID: 8233543.
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    224. Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801. Pain. 1993 Jul; 54(1):79-84. Yamamoto T, Yaksh TL. PMID: 8378105.
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    225. Effects of intrathecal capsaicin and an NK-1 antagonist, CP,96-345, on the thermal hyperalgesia observed following unilateral constriction of the sciatic nerve in the rat. Pain. 1992 Dec; 51(3):329-34. Yamamoto T, Yaksh TL. PMID: 1337198.
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    226. Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists. Pain. 1992 Apr; 49(1):121-8. Yamamoto T, Yaksh TL. PMID: 1594273.
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    227. Leakage of fluid after epidural injection. Pain. 1991 Mar; 44(3):325. Yaksh TL. PMID: 2052401.
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    228. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain. 1989 Apr; 37(1):111-23. Yaksh TL. PMID: 2542867.
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    229. Retrospective consideration of the doses of morphine given intrathecally by chronic infusion in 163 patients by 19 physicians. Pain. 1987 Nov; 31(2):211-23. Yaksh TL, Onofrio BM. PMID: 3431881.
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    230. The analgesic efficacy of intrathecal D-Ala2-D-Leu5-enkephalin in cancer patients with chronic pain. Pain. 1985 Nov; 23(3):213-21. Moulin DE, Max MB, Kaiko RF, Inturrisi CE, Maggard J, Yaksh TL, Foley KM. PMID: 3906516.
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    231. Spinal cord monoamines modulate the antinociceptive effects of vaginal stimulation in rats. Pain. 1983 Jun; 16(2):155-66. Steinman JL, Komisaruk BR, Yaksh TL, Tyce GM. PMID: 6877846.
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    232. Peripheral and central substrates involved in the rostrad transmission of nociceptive information. Pain. 1982 May; 13(1):1-85. Yaksh TL, Hammond DL. PMID: 6287384.
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