Edward Koo

Title(s)Recall Faculty, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Multidisciplinary training in basic and translational Alzheimer's disease research
    NIH T32AG066596May 1, 2020 - Apr 30, 2025
    Role: Principal Investigator
    Mechanisms of abeta induced dysfunction in hippocampal neuronal circuitry
    NIH R01NS084324Apr 1, 2014 - Mar 31, 2020
    Role: Principal Investigator
    Abeta42 Altering Compounds: Mechanisms of Action
    NIH R01AG029886Aug 1, 2008 - May 31, 2009
    Role: Principal Investigator
    Synaptic damage in models of beta-amyloid associated pathology
    NIH R01AG032179Sep 15, 2007 - Aug 31, 2013
    Role: Principal Investigator
    Novel Mechanisms of NSAID Action in Alzheimer's Disease
    NIH P01AG020206Apr 1, 2002 - Jun 30, 2015
    Role: Principal Investigator
    APP INTERNALIZATION--PREREQUISITE FOR ABETA FORMATION?
    NIH K04NS001812May 1, 1996 - Apr 30, 2001
    Role: Principal Investigator
    APP Trafficking and the Pathways of A Beta Formation
    NIH R01AG012376Sep 1, 1994 - Dec 31, 2008
    Role: Principal Investigator
    Training in the Neuroplasticity of Aging
    NIH T32AG000216Sep 30, 1992 - Apr 30, 2018
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH P50AG005131Sep 28, 1984 - Mar 31, 2020
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Extracellular Vesicle-Enriched miRNA-Biomarkers Show Improved Utility for Detecting Alzheimer's Disease Dementia and Medial Temporal Atrophy. J Alzheimers Dis. 2024; 99(4):1317-1331. Chai YL, Strohm L, Zhu Y, Chia RSL, Chong JR, Suresh DD, Zhou LH, Too HP, Hilal S, Radivoyevitch T, Koo EH, Chen CP, Poplawski GHD. PMID: 38788066; PMCID: PMC11191453.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Localized APP expression results in progressive network dysfunction by disorganizing spike timing. Neuron. 2024 Jan 03; 112(1):124-140.e6. Viana da Silva S, Haberl MG, Gaur K, Patel R, Narayan G, Ledakis M, Fu ML, de Castro Vieira M, Koo EH, Leutgeb JK, Leutgeb S. PMID: 37909036; PMCID: PMC10877582.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons. iScience. 2023 Nov 17; 26(11):108152. Ho WY, Chak LL, Hor JH, Liu F, Diaz-Garcia S, Chang JC, Sanford E, Rodriguez MJ, Alagappan D, Lim SM, Cho YL, Shimizu Y, Sun AX, Tyan SH, Koo E, Kim SH, Ravits J, Ng SY, Okamura K, Ling SC. PMID: 37920668; PMCID: PMC10618709.
      View in: PubMed   Mentions: 2  
    4. APP family member dimeric complexes are formed predominantly in synaptic compartments. Cell Biosci. 2023 Aug 02; 13(1):141. Schilling S, August A, Meleux M, Conradt C, Tremmel LM, Teigler S, Adam V, Müller UC, Koo EH, Kins S, Eggert S. PMID: 37533067; PMCID: PMC10398996.
      View in: PubMed   Mentions:
    5. Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment. Cell Rep. 2023 07 25; 42(7):112774. Aow J, Huang TR, Goh YT, Sun AX, Thinakaran G, Koo EH. PMID: 37450368; PMCID: PMC10449584.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity. Acta Neuropathol Commun. 2023 06 01; 11(1):87. Schilling S, Pradhan A, Heesch A, Helbig A, Blennow K, Koch C, Bertgen L, Koo EH, Brinkmalm G, Zetterberg H, Kins S, Eggert S. PMID: 37259128; PMCID: PMC10234039.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Chronic cerebral hypoperfusion alters the CypA-EMMPRIN-gelatinase pathway: Implications for vascular dementia. J Cereb Blood Flow Metab. 2023 05; 43(5):722-735. Chai YL, Rajeev V, Poh L, Selvaraji S, Hilal S, Chen CP, Jo DG, Koo EH, Arumugam TV, Lai MK. PMID: 36537035; PMCID: PMC10108186.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    8. Enhanced cleavage of APP by co-expressed Bace1 alters the distribution of APP and its fragments in neuronal and non-neuronal cells. Mol Neurobiol. 2022 May; 59(5):3073-3090. Aow J, Huang TR, Thinakaran G, Koo EH. PMID: 35266114.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. SINgapore GERiatric intervention study to reduce physical frailty and cognitive decline (SINGER)-pilot: A feasibility study. Alzheimers Dement (N Y). 2021; 7(1):e12141. Chew KA, Xu X, Siongco P, Villaraza S, Phua AKS, Wong ZX, Chung CY, Tang N, Chew E, Henry CJ, Koo E, Chen C. PMID: 33748399; PMCID: PMC7958306.
      View in: PubMed   Mentions: 8  
    10. Machine learning classifies predictive kinematic features in a mouse model of neurodegeneration. Sci Rep. 2021 02 17; 11(1):3950. Huang R, Nikooyan AA, Xu B, Joseph MS, Damavandi HG, von Trotha N, Li L, Bhattarai A, Zadeh D, Seo Y, Liu X, Truong PA, Koo EH, Leiter JC, Lu DC. PMID: 33597593; PMCID: PMC7889656.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    11. Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits. Acta Neuropathol Commun. 2021 01 06; 9(1):9. Ho WY, Agrawal I, Tyan SH, Sanford E, Chang WT, Lim K, Ong J, Tan BSY, Moe AAK, Yu R, Wong P, Tucker-Kellogg G, Koo E, Chuang KH, Ling SC. PMID: 33407930; PMCID: PMC7789430.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    12. World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia. Alzheimers Dement. 2020 07; 16(7):1078-1094. Kivipelto M, Mangialasche F, Snyder HM, Allegri R, Andrieu S, Arai H, Baker L, Belleville S, Brodaty H, Brucki SM, Calandri I, Caramelli P, Chen C, Chertkow H, Chew E, Choi SH, Chowdhary N, Crivelli L, Torre R, Du Y, Dua T, Espeland M, Feldman HH, Hartmanis M, Hartmann T, Heffernan M, Henry CJ, Hong CH, Håkansson K, Iwatsubo T, Jeong JH, Jimenez-Maggiora G, Koo EH, Launer LJ, Lehtisalo J, Lopera F, Martínez-Lage P, Martins R, Middleton L, Molinuevo JL, Montero-Odasso M, Moon SY, Morales-Pérez K, Nitrini R, Nygaard HB, Park YK, Peltonen M, Qiu C, Quiroz YT, Raman R, Rao N, Ravindranath V, Rosenberg A, Sakurai T, Salinas RM, Scheltens P, Sevlever G, Soininen H, Sosa AL, Suemoto CK, Tainta-Cuezva M, Velilla L, Wang Y, Whitmer R, Whitmer R, Xu X, Bain LJ, Solomon A, Ngandu T, Carrillo MC. PMID: 32627328; PMCID: PMC9527644.
      View in: PubMed   Mentions: 191     Fields:    Translation:Humans
    13. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease. Cell Rep. 2020 06 30; 31(13):107839. Park G, Nhan HS, Tyan SH, Kawakatsu Y, Zhang C, Navarro M, Koo EH. PMID: 32610140; PMCID: PMC7375398.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    14. Presymptomatic Increase of an Extracellular RNA in Blood Plasma Associates with the Development of Alzheimer's Disease. Curr Biol. 2020 05 18; 30(10):1771-1782.e3. Yan Z, Zhou Z, Wu Q, Chen ZB, Koo EH, Zhong S. PMID: 32220323.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    15. PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response. J Biol Chem. 2020 01 03; 295(1):237-249. Hiramatsu N, Chiang K, Aivati C, Rodvold JJ, Lee JM, Han J, Chea L, Zanetti M, Koo EH, Lin JH. PMID: 31792031; PMCID: PMC6952592.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    16. FUS-mediated dysregulation of Sema5a, an autism-related gene, in FUS mice with hippocampus-dependent cognitive deficits. Hum Mol Genet. 2019 11 15; 28(22):3777-3791. Ho WY, Chang JC, Tyan SH, Yen YC, Lim K, Tan BSY, Ong J, Tucker-Kellogg G, Wong P, Koo E, Ling SC. PMID: 31509188.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice. Brain Behav Immun. 2019 08; 80:344-357. Kim J, Selvaraji S, Kang SW, Lee WT, Chen CL, Choi H, Koo EH, Jo DG, Leong Lim K, Lim YA, Arumugam TV. PMID: 30980950.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy. Autophagy. 2019 05; 15(5):827-842. Ho WY, Tai YK, Chang JC, Liang J, Tyan SH, Chen S, Guan JL, Zhou H, Shen HM, Koo E, Ling SC. PMID: 30669939; PMCID: PMC6526867.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    19. Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress. Hum Mol Genet. 2018 11 15; 27(22):3951-3963. Yuan SH, Hiramatsu N, Liu Q, Sun XV, Lenh D, Chan P, Chiang K, Koo EH, Kao AW, Litvan I, Lin JH. PMID: 30137327; PMCID: PMC6216228.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    20. Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke. Brain Behav Immun. 2019 01; 75:34-47. Poh L, Kang SW, Baik SH, Ng GYQ, She DT, Balaganapathy P, Dheen ST, Magnus T, Gelderblom M, Sobey CG, Koo EH, Fann DY, Arumugam TV. PMID: 30195027.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    21. Microinterventional endocapsular nucleus disassembly for phacoemulsification-free full-thickness fragmentation. J Cataract Refract Surg. 2018 Aug; 44(8):932-934. Ianchulev T, Chang DF, Koo E, MacDonald S. PMID: 30115295.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death Differ. 2018 03; 25(4):663-678. Liu C, Zhang CW, Zhou Y, Wong WQ, Lee LC, Ong WY, Yoon SO, Hong W, Fu XY, Soong TW, Koo EH, Stanton LW, Lim KL, Xiao ZC, Dawe GS. PMID: 29238071; PMCID: PMC5864187.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    23. Short Aβ peptides attenuate Aβ42 toxicity in vivo. J Exp Med. 2018 01 02; 215(1):283-301. Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, Rincon-Limas D, Fernandez-Funez P, Golde TE. PMID: 29208777; PMCID: PMC5748850.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    24. Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology. Cell Rep. 2017 Nov 28; 21(9):2614-2627. Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, Ghosh A, Yates JR. PMID: 29186695; PMCID: PMC5726791.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    25. Transcriptional regulation of APP by apoE: To boldly go where no isoform has gone before: ApoE, APP transcription and AD: Hypothesised mechanisms and existing knowledge gaps. Bioessays. 2017 09; 39(9). Lee LC, Goh MQL, Koo EH. PMID: 28731260; PMCID: PMC5647194.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    26. APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. J Neurosci. 2017 05 24; 37(21):5345-5365. Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S, Eggert S. PMID: 28450540; PMCID: PMC6596463.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    27. The Utility of Brief Cognitive Tests for Patients With Type 2 Diabetes Mellitus: A Systematic Review. J Am Med Dir Assoc. 2016 10 01; 17(10):889-95. Dong Y, Kua ZJ, Khoo EY, Koo EH, Merchant RA. PMID: 27461866.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    28. Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice. Biochem Biophys Res Commun. 2016 09 09; 478(1):286-292. Park SA, Chevallier N, Tejwani K, Hung MM, Maruyama H, Golde TE, Koo EH. PMID: 27425247.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    29. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). PLoS One. 2015; 10(12):e0144758. Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH. PMID: 26678856; PMCID: PMC4683055.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    30. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan; 19(1):55-64. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. PMID: 26642089; PMCID: PMC4782935.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    31. Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP. Front Behav Neurosci. 2015; 9:299. Nizetic D, Chen CL, Hong W, Koo EH. PMID: 26648852; PMCID: PMC4664698.
      View in: PubMed   Mentions: 4  
    32. New tricks from an old dog: Another synaptotoxic fragment from APP. Cell Res. 2015 Nov; 25(11):1185-6. Tyan SH, Koo EH. PMID: 26503171; PMCID: PMC4650427.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    33. Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans. Alzheimers Res Ther. 2015; 7(1):55. Ling IF, Golde TE, Galasko DR, Koo EH. PMID: 26244059; PMCID: PMC4523931.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    34. Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. Mol Neurodegener. 2015 Jul 14; 10:29. Jung JI, Price AR, Ladd TB, Ran Y, Park HJ, Ceballos-Diaz C, Smithson LA, Hochhaus G, Tang Y, Akula R, Ba S, Koo EH, Shapiro G, Felsenstein KM, Golde TE. PMID: 26169917; PMCID: PMC4501119.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    35. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Alzheimer's Disease Genetics Consortium, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, National Institute on Aging-Late-Onset Alzheimer’s Disease (NIA-LOAD) Family Study, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25531812; PMCID: PMC4324097.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    36. Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014 Dec; 71(12):1481-9. Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. PMID: 25285942; PMCID: PMC4374637.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    37. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Alzheimer Disease Genetics Consortium, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25199842; PMCID: PMC4314944.
      View in: PubMed   Mentions: 103     Fields:    Translation:Humans
    38. Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity. PLoS One. 2014; 9(10):e111553. Jung JI, Premraj S, Cruz PE, Ladd TB, Kwak Y, Koo EH, Felsenstein KM, Golde TE, Ran Y. PMID: 25350374; PMCID: PMC4211736.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    39. The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes. Acta Neuropathol. 2015 Jan; 129(1):1-19. Nhan HS, Chiang K, Koo EH. PMID: 25287911; PMCID: PMC4282969.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimals
    40. Neurotoxic effects of dexmedetomidine in fetal cynomolgus monkey brains. J Toxicol Sci. 2014 Apr; 39(2):251-62. Koo E, Oshodi T, Meschter C, Ebrahimnejad A, Dong G. PMID: 24646706.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    41. Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators. Biochemistry. 2014 Apr 01; 53(12):1947-57. Jung JI, Ran Y, Cruz PE, Rosario AM, Ladd TB, Kukar TL, Koo EH, Felsenstein KM, Golde TE. PMID: 24620716; PMCID: PMC3985764.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    42. Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. PLoS One. 2014; 9(1):e84349. Wilke SA, Raam T, Antonios JK, Bushong EA, Koo EH, Ellisman MH, Ghosh A. PMID: 24454724; PMCID: PMC3890281.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    43. Emerging therapeutics for Alzheimer's disease. Annu Rev Pharmacol Toxicol. 2014; 54:381-405. Chiang K, Koo EH. PMID: 24392696.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    44. The--YENPTY--domain of the amyloid precursor protein: much more than just endocytosis? Bioessays. 2013 Oct; 35(10):844. Nhan HS, Koo EH. PMID: 24078548.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    45. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci. 2013 Sep 25; 33(39):15596-602. Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo EH, Masliah E, Tuszynski MH. PMID: 24068826; PMCID: PMC3782628.
      View in: PubMed   Mentions: 82     Fields:    Translation:Animals
    46. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 07; 79(3):447-60. Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. PMID: 23931995; PMCID: PMC3741682.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    47. γ-Secretase inhibitors and modulators. Biochim Biophys Acta. 2013 Dec; 1828(12):2898-907. Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L. PMID: 23791707; PMCID: PMC3857966.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    48. Steroids as γ-secretase modulators. FASEB J. 2013 Sep; 27(9):3775-85. Jung JI, Ladd TB, Kukar T, Price AR, Moore BD, Koo EH, Golde TE, Felsenstein KM. PMID: 23716494; PMCID: PMC3752532.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    49. Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study. J Neurol Neurosurg Psychiatry. 2013 Jun; 84(6):686-92. Hilal S, Ikram MK, Saini M, Tan CS, Catindig JA, Dong YH, Lim LB, Ting EY, Koo EH, Cheung CY, Qiu A, Wong TY, Chen CL, Venketasubramanian N. PMID: 23385846.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    50. Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity. J Neurochem. 2012 Dec; 123(5):856-65. Park SS, Jung HJ, Kim YJ, Park TK, Kim C, Choi H, Mook-Jung IH, Koo EH, Park SA. PMID: 23020770.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    51. Amyloid precursor protein (APP) regulates synaptic structure and function. Mol Cell Neurosci. 2012 Aug; 51(1-2):43-52. Tyan SH, Shih AY, Walsh JJ, Maruyama H, Sarsoza F, Ku L, Eggert S, Hof PR, Koo EH, Dickstein DL. PMID: 22884903; PMCID: PMC3538857.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    52. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N, Alzheimer's Disease Genetics Consortium (ADGC), Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach T, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Crane PK, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dombroski BA, Duara R, Ellis WD, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch M, Galasko DR, Gallins PJ, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JS, Kaye JA, Kennedy N, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Myers AJ, Naj AC, Nowotny P, Parisi JE, Perl DP, Peskind E, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL. PMID: 22722634; PMCID: PMC3398432.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    53. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers. Traffic. 2012 May; 13(5):681-93. Tang Y, Scott DA, Das U, Edland SD, Radomski K, Koo EH, Roy S. PMID: 22309053; PMCID: PMC3593673.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    54. Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. Mol Cell Neurosci. 2012 Apr; 49(4):448-55. Midthune B, Tyan SH, Walsh JJ, Sarsoza F, Eggert S, Hof PR, Dickstein DL, Koo EH. PMID: 22353605; PMCID: PMC3348437.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    55. Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. FASEB J. 2012 May; 26(5):2072-83. Lakshmana MK, Hayes CD, Bennett SP, Bianchi E, Reddy KM, Koo EH, Kang DE. PMID: 22294787; PMCID: PMC3336780.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    56. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25; 482(7384):216-20. Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. PMID: 22278060; PMCID: PMC3338985.
      View in: PubMed   Mentions: 623     Fields:    Translation:HumansCells
    57. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region. J Biol Chem. 2011 Nov 18; 286(46):39804-12. Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, Golde TE. PMID: 21868378; PMCID: PMC3220543.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    58. Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein. J Biol Chem. 2011 Nov 18; 286(46):39794-803. Sagi SA, Lessard CB, Winden KD, Maruyama H, Koo JC, Weggen S, Kukar TL, Golde TE, Koo EH. PMID: 21868380; PMCID: PMC3220583.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    59. Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener. 2011 Apr 28; 6(1):27. Zheng H, Koo EH. PMID: 21527012; PMCID: PMC3098799.
      View in: PubMed   Mentions: 155     Fields:    
    60. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. PMID: 21460841; PMCID: PMC3090745.
      View in: PubMed   Mentions: 1078     Fields:    Translation:Humans
    61. Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron. 2011 Jan 27; 69(2):203-13. Golde TE, Schneider LS, Koo EH. PMID: 21262461; PMCID: PMC3058906.
      View in: PubMed   Mentions: 195     Fields:    Translation:Humans
    62. And four equals one: presenilin takes the gamma-secretase role by itself. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21236-7. Lessard CB, Wagner SL, Koo EH. PMID: 21135249; PMCID: PMC3003118.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    63. Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site. Nat Commun. 2010 Nov 30; 1:130. Uemura K, Farner KC, Hashimoto T, Nasser-Ghodsi N, Wolfe MS, Koo EH, Hyman BT, Berezovska O. PMID: 21119643; PMCID: PMC3060602.
      View in: PubMed   Mentions: 26     Fields:    
    64. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem. 2009 Dec; 111(6):1369-82. Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU. PMID: 19804379.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    65. A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation. FASEB J. 2010 Jan; 24(1):119-27. Lakshmana MK, Chung JY, Wickramarachchi S, Tak E, Bianchi E, Koo EH, Kang DE. PMID: 19729516; PMCID: PMC2797034.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    66. Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):450-5. Park SA, Shaked GM, Bredesen DE, Koo EH. PMID: 19679105; PMCID: PMC2838490.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    67. Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production. J Biol Chem. 2009 Oct 16; 284(42):28943-52. Eggert S, Midthune B, Cottrell B, Koo EH. PMID: 19596858; PMCID: PMC2781440.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    68. Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation. J Biol Chem. 2009 May 01; 284(18):11863-72. Lakshmana MK, Yoon IS, Chen E, Bianchi E, Koo EH, Kang DE. PMID: 19251705; PMCID: PMC2673255.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    69. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009 Mar; 15(3):331-7. Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA, Tuszynski MH. PMID: 19198615; PMCID: PMC2838375.
      View in: PubMed   Mentions: 456     Fields:    Translation:Animals
    70. Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase. J Biol Chem. 2009 Jan 23; 284(4):2296-306. Kummer MP, Maruyama H, Huelsmann C, Baches S, Weggen S, Koo EH. PMID: 19047044; PMCID: PMC2629115.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    71. Amyloid precursor protein trafficking, processing, and function. J Biol Chem. 2008 Oct 31; 283(44):29615-9. Thinakaran G, Koo EH. PMID: 18650430; PMCID: PMC2573065.
      View in: PubMed   Mentions: 524     Fields:    Translation:HumansAnimalsCells
    72. Substrate-targeting gamma-secretase modulators. Nature. 2008 Jun 12; 453(7197):925-9. Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. PMID: 18548070; PMCID: PMC2678541.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    73. A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimers Dement. 2008 May; 4(3):156-63. Khachaturian ZS, Petersen RC, Gauthier S, Buckholtz N, Corey-Bloom JP, Evans B, Fillit H, Foster N, Greenberg B, Grundman M, Sano M, Simpkins J, Schneider LS, Weiner MW, Galasko D, Hyman B, Kuller L, Schenk D, Snyder S, Thomas RG, Tuszynski MH, Vellas B, Wurtman RJ, Snyder PJ, Frank RA, Albert M, Doody R, Ferris S, Kaye J, Koo E, Morrison-Bogorad M, Reisberg B, Salmon DP, Gilman S, Mohs R, Aisen PS, Breitner JC, Cummings JL, Kawas C, Phelps C, Poirier J, Sabbagh M, Touchon J, Khachaturian AS, Bain LJ. PMID: 18631960; PMCID: PMC2544623.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    74. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. J Biol Chem. 2008 Jun 20; 283(25):17049-54. Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S. PMID: 18426795.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    75. C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis. 2008 Feb; 13(1):1-16. Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EH, Bredesen DE. PMID: 18334752; PMCID: PMC2818039.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    76. Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Dis Assoc Disord. 2007 Oct-Dec; 21(4):292-9. Galasko DR, Graff-Radford N, May S, Hendrix S, Cottrell BA, Sagi SA, Mather G, Laughlin M, Zavitz KH, Swabb E, Golde TE, Murphy MP, Koo EH. PMID: 18090435.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCTClinical Trials
    77. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 2007 Jul 24; 8:54. Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM. PMID: 17650315; PMCID: PMC1948891.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    78. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. J Biol Chem. 2007 Aug 24; 282(34):24504-13. Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S. PMID: 17573346.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    79. Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway. FASEB J. 2007 Sep; 21(11):2742-52. Yoon IS, Chen E, Busse T, Repetto E, Lakshmana MK, Koo EH, Kang DE. PMID: 17463224.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    80. Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein. Mol Cell Neurosci. 2007 Jun; 35(2):183-93. Calabrese B, Shaked GM, Tabarean IV, Braga J, Koo EH, Halpain S. PMID: 17368908; PMCID: PMC2268524.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    81. Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J Neurosci. 2006 Dec 27; 26(52):13428-36. Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo EH, Heinemann SF. PMID: 17192425; PMCID: PMC6674728.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    82. The amyloid precursor protein: beyond amyloid. Mol Neurodegener. 2006 Jul 03; 1:5. Zheng H, Koo EH. PMID: 16930452; PMCID: PMC1538601.
      View in: PubMed   Mentions: 159     Fields:    
    83. To think or not to think: synaptic activity and Abeta release. Neuron. 2005 Dec 22; 48(6):873-5. Schroeder BE, Koo EH. PMID: 16364890.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    84. Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. J Neurochem. 2006 Jan; 96(2):355-65. Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S. PMID: 16300630.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    85. A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol. 2005 Aug; 58(2):277-89. Cottrell BA, Galvan V, Banwait S, Gorostiza O, Lombardo CR, Williams T, Schilling B, Peel A, Gibson B, Koo EH, Link CD, Bredesen DE. PMID: 16049941; PMCID: PMC1847583.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    86. Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. J Biol Chem. 2005 Sep 09; 280(36):31537-47. Kang DE, Yoon IS, Repetto E, Busse T, Yermian N, Ie L, Koo EH. PMID: 16014629.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    87. Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. Am J Pathol. 2005 Jul; 167(1):151-9. Chevallier NL, Soriano S, Kang DE, Masliah E, Hu G, Koo EH. PMID: 15972961; PMCID: PMC1603433.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    88. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem. 2005 Jul 22; 280(29):27303-9. Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O. PMID: 15917251.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    89. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nat Med. 2005 May; 11(5):545-50. Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE. PMID: 15834426.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    90. Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. J Biol Chem. 2005 May 20; 280(20):20140-7. Yoon IS, Pietrzik CU, Kang DE, Koo EH. PMID: 15772078.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    91. The endocytotic pathway is required for increased A beta 42 secretion during apoptosis. Brain Res Mol Brain Res. 2004 Sep 28; 128(2):201-11. Sodhi CP, Rampalli S, Perez RG, Koo EH, Quinn B, Gottardi-Littell NR. PMID: 15363895.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    92. Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat Med. 2004 Jul; 10 Suppl:S26-33. Koo EH, Kopan R. PMID: 15272268.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    93. FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci. 2004 Apr 28; 24(17):4259-65. Pietrzik CU, Yoon IS, Jaeger S, Busse T, Weggen S, Koo EH. PMID: 15115822; PMCID: PMC6729272.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    94. Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Ann Neurol. 2003 Dec; 54(6):781-9. Lu DC, Shaked GM, Masliah E, Bredesen DE, Koo EH. PMID: 14681887.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    95. Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem. 2003 Nov; 87(3):733-41. Lu DC, Soriano S, Bredesen DE, Koo EH. PMID: 14535955.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    96. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest. 2003 Aug; 112(3):440-9. Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE. PMID: 12897211; PMCID: PMC166298.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansAnimalsCells
    97. The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production. J Biol Chem. 2003 Aug 22; 278(34):31825-30. Sagi SA, Weggen S, Eriksen J, Golde TE, Koo EH. PMID: 12805355.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    98. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem. 2003 Aug 22; 278(34):31831-7. Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo EH. PMID: 12805356.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    99. Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem. 2003 Aug 15; 278(33):30748-54. Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Golde TE, Koo EH. PMID: 12777371.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    100. Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. J Biol Chem. 2003 Jul 04; 278(27):24294-301. Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y. PMID: 12707272.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    101. The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog? Traffic. 2002 Nov; 3(11):763-70. Koo EH. PMID: 12383342.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    102. The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO J. 2002 Nov 01; 21(21):5691-700. Pietrzik CU, Busse T, Merriam DE, Weggen S, Koo EH. PMID: 12411487; PMCID: PMC131065.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    103. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis. 2002 Oct; 11(1):64-82. Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. PMID: 12460547.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    104. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell. 2002 Sep 20; 110(6):751-62. Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo EH. PMID: 12297048.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    105. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell. 2002 Jul 12; 110(1):55-67. Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG. PMID: 12150997.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansAnimalsCells
    106. Caspase cleavage of members of the amyloid precursor family of proteins. J Neurochem. 2002 Jul; 82(2):283-94. Galvan V, Chen S, Lu D, Logvinova A, Goldsmith P, Koo EH, Bredesen DE. PMID: 12124429.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    107. The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8760-5. Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H. PMID: 12070348; PMCID: PMC124372.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
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