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    Edward Koo

    TitleRecall Faculty
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0691
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Mechanisms of abeta induced dysfunction in hippocampal neuronal circuitry
      NIH/NINDS R01NS084324Apr 1, 2014 - Mar 31, 2019
      Role: Principal Investigator
      Abeta42 Altering Compounds: Mechanisms of Action
      NIH/NIA R01AG029886Aug 1, 2008 - May 31, 2009
      Role: Principal Investigator
      Synaptic damage in models of beta-amyloid associated pathology
      NIH/NIA R01AG032179Sep 15, 2007 - Aug 31, 2013
      Role: Principal Investigator
      Novel Mechanisms of NSAID Action in Alzheimer's Disease
      NIH/NIA P01AG020206Apr 1, 2002 - Jun 30, 2014
      Role: Principal Investigator
      NIH/NINDS K04NS001812May 1, 1996 - Apr 30, 2001
      Role: Principal Investigator
      APP Trafficking and the Pathways of A Beta Formation
      NIH/NIA R01AG012376Sep 1, 1994 - Dec 31, 2008
      Role: Principal Investigator
      Training in the Neuroplasticity of Aging
      NIH/NIA T32AG000216Sep 30, 1992 - Apr 30, 2017
      Role: Principal Investigator
      UCSD Alzheimer's Disease Research Center P50
      NIH/NIA P50AG005131Sep 28, 1984 - Mar 31, 2019
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Park SA, Chevallier N, Tejwani K, Hung MM, Maruyama H, Golde TE, Koo E. Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice. Biochem Biophys Res Commun. 2016 Sep 09; 478(1):286-292. PMID: 27425247.
        View in: PubMed
      2. Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo E. ?-Secretase Modulators and APH1 Isoforms Modulate ?-Secretase Cleavage but Not Position of e-Cleavage of the Amyloid Precursor Protein (APP). PLoS One. 2015; 10(12):e0144758. PMID: 26678856; PMCID: PMC4683055.
      3. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo E, Roy S. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan; 19(1):55-64. PMID: 26642089; PMCID: PMC4782935.
      4. Nizetic D, Chen CL, Hong W, Koo E. Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP. Front Behav Neurosci. 2015; 9:299. PMID: 26648852; PMCID: PMC4664698.
      5. Ling IF, Golde TE, Galasko DR, Koo E. Modulation of Aß42 in vivo by ?-secretase modulator in primates and humans. Alzheimers Res Ther. 2015; 7(1):55. PMID: 26244059; PMCID: PMC4523931.
      6. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo E, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. PMID: 25531812; PMCID: PMC4324097.
      7. Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo E, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. Effect of potent ?-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014 Dec; 71(12):1481-9. PMID: 25285942; PMCID: PMC4374637.
      8. Jung JI, Premraj S, Cruz PE, Ladd TB, Kwak Y, Koo E, Felsenstein KM, Golde TE, Ran Y. Independent relationship between amyloid precursor protein (APP) dimerization and ?-secretase processivity. PLoS One. 2014; 9(10):e111553. PMID: 25350374; PMCID: PMC4211736.
      9. Nhan HS, Chiang K, Koo E. The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes. Acta Neuropathol. 2015 Jan; 129(1):1-19. PMID: 25287911; PMCID: PMC4282969.
      10. Wilke SA, Raam T, Antonios JK, Bushong EA, Koo E, Ellisman MH, Ghosh A. Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. PLoS One. 2014; 9(1):e84349. PMID: 24454724; PMCID: PMC3890281.
      11. Chiang K, Koo E. Emerging therapeutics for Alzheimer's disease. Annu Rev Pharmacol Toxicol. 2014; 54:381-405. PMID: 24392696.
        View in: PubMed
      12. Nhan HS, Koo E. The--YENPTY--domain of the amyloid precursor protein: much more than just endocytosis? Bioessays. 2013 Oct; 35(10):844. PMID: 24078548.
        View in: PubMed
      13. Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo E, Masliah E, Tuszynski MH. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci. 2013 Sep 25; 33(39):15596-602. PMID: 24068826; PMCID: PMC3782628.
      14. Das U, Scott DA, Ganguly A, Koo E, Tang Y, Roy S. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 07; 79(3):447-60. PMID: 23931995; PMCID: PMC3741682.
      15. Golde TE, Koo E, Felsenstein KM, Osborne BA, Miele L. ?-Secretase inhibitors and modulators. Biochim Biophys Acta. 2013 Dec; 1828(12):2898-907. PMID: 23791707; PMCID: PMC3857966.
      16. Park SS, Jung HJ, Kim YJ, Park TK, Kim C, Choi H, Mook-Jung IH, Koo E, Park SA. Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity. J Neurochem. 2012 Dec; 123(5):856-65. PMID: 23020770.
        View in: PubMed
      17. Tyan SH, Shih AY, Walsh JJ, Maruyama H, Sarsoza F, Ku L, Eggert S, Hof PR, Koo E, Dickstein DL. Amyloid precursor protein (APP) regulates synaptic structure and function. Mol Cell Neurosci. 2012 Aug; 51(1-2):43-52. PMID: 22884903; PMCID: PMC3538857.
      18. Tang Y, Scott DA, Das U, Edland SD, Radomski K, Koo E, Roy S. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid ß-protein oligomers. Traffic. 2012 May; 13(5):681-93. PMID: 22309053; PMCID: PMC3593673.
      19. Midthune B, Tyan SH, Walsh JJ, Sarsoza F, Eggert S, Hof PR, Dickstein DL, Koo E. Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. Mol Cell Neurosci. 2012 Apr; 49(4):448-55. PMID: 22353605; PMCID: PMC3348437.
      20. Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo E, Golde TE. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid ß peptide length: support for a sequential model of ?-secretase intramembrane proteolysis and regulation by the amyloid ß precursor protein (APP) juxtamembrane region. J Biol Chem. 2011 Nov 18; 286(46):39804-12. PMID: 21868378; PMCID: PMC3220543.
      21. Sagi SA, Lessard CB, Winden KD, Maruyama H, Koo JC, Weggen S, Kukar TL, Golde TE, Koo E. Substrate sequence influences ?-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein. J Biol Chem. 2011 Nov 18; 286(46):39794-803. PMID: 21868380; PMCID: PMC3220583.
      22. Zheng H, Koo E. Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener. 2011 Apr 28; 6(1):27. PMID: 21527012; PMCID: PMC3098799.
      23. Golde TE, Schneider LS, Koo E. Anti-aß therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron. 2011 Jan 27; 69(2):203-13. PMID: 21262461; PMCID: PMC3058906.
      24. Lessard CB, Wagner SL, Koo E. And four equals one: presenilin takes the gamma-secretase role by itself. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21236-7. PMID: 21135249; PMCID: PMC3003118.
      25. Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo E, Heneka M, Weggen S, Pietrzik CU. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem. 2009 Dec; 111(6):1369-82. PMID: 19804379.
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      26. Lakshmana MK, Chung JY, Wickramarachchi S, Tak E, Bianchi E, Koo E, Kang DE. A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation. FASEB J. 2010 Jan; 24(1):119-27. PMID: 19729516; PMCID: PMC2797034.
      27. Park SA, Shaked GM, Bredesen DE, Koo E. Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):450-5. PMID: 19679105; PMCID: PMC2838490.
      28. Eggert S, Midthune B, Cottrell B, Koo E. Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production. J Biol Chem. 2009 Oct 16; 284(42):28943-52. PMID: 19596858; PMCID: PMC2781440.
      29. Lakshmana MK, Yoon IS, Chen E, Bianchi E, Koo E, Kang DE. Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation. J Biol Chem. 2009 May 01; 284(18):11863-72. PMID: 19251705; PMCID: PMC2673255.
      30. Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo E, Geschwind D, Masliah E, Chiba AA, Tuszynski MH. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009 Mar; 15(3):331-7. PMID: 19198615; PMCID: PMC2838375.
      31. Kummer MP, Maruyama H, Huelsmann C, Baches S, Weggen S, Koo E. Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase. J Biol Chem. 2009 Jan 23; 284(4):2296-306. PMID: 19047044; PMCID: PMC2629115.
      32. Thinakaran G, Koo E. Amyloid precursor protein trafficking, processing, and function. J Biol Chem. 2008 Oct 31; 283(44):29615-9. PMID: 18650430; PMCID: PMC2573065.
      33. Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo E, Golde TE. Substrate-targeting gamma-secretase modulators. Nature. 2008 Jun 12; 453(7197):925-9. PMID: 18548070; PMCID: PMC2678541.
      34. Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo E, Weggen S. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. J Biol Chem. 2008 Jun 20; 283(25):17049-54. PMID: 18426795.
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      35. Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo E, Bredesen DE. C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis. 2008 Feb; 13(1):1-16. PMID: 18334752; PMCID: PMC2818039.
      36. Galasko DR, Graff-Radford N, May S, Hendrix S, Cottrell BA, Sagi SA, Mather G, Laughlin M, Zavitz KH, Swabb E, Golde TE, Murphy MP, Koo E. Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Dis Assoc Disord. 2007 Oct-Dec; 21(4):292-9. PMID: 18090435.
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      37. Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo E, Golde TE, Nicolle MM. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 2007 Jul 24; 8:54. PMID: 17650315; PMCID: PMC1948891.
      38. Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo E, Pietrzik CU, Baumann K, Weggen S. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. J Biol Chem. 2007 Aug 24; 282(34):24504-13. PMID: 17573346.
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      39. Yoon IS, Chen E, Busse T, Repetto E, Lakshmana MK, Koo E, Kang DE. Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway. FASEB J. 2007 Sep; 21(11):2742-52. PMID: 17463224.
        View in: PubMed
      40. Calabrese B, Shaked GM, Tabarean IV, Braga J, Koo E, Halpain S. Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein. Mol Cell Neurosci. 2007 Jun; 35(2):183-93. PMID: 17368908; PMCID: PMC2268524.
      41. Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo E, Heinemann SF. Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J Neurosci. 2006 Dec 27; 26(52):13428-36. PMID: 17192425.
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      42. Zheng H, Koo E. The amyloid precursor protein: beyond amyloid. Mol Neurodegener. 2006 Jul 03; 1:5. PMID: 16930452; PMCID: PMC1538601.
      43. Schroeder BE, Koo E. To think or not to think: synaptic activity and Abeta release. Neuron. 2005 Dec 22; 48(6):873-5. PMID: 16364890.
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      44. Cottrell BA, Galvan V, Banwait S, Gorostiza O, Lombardo CR, Williams T, Schilling B, Peel A, Gibson B, Koo E, Link CD, Bredesen DE. A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol. 2005 Aug; 58(2):277-89. PMID: 16049941; PMCID: PMC1847583.
      45. Kang DE, Yoon IS, Repetto E, Busse T, Yermian N, Ie L, Koo E. Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. J Biol Chem. 2005 Sep 09; 280(36):31537-47. PMID: 16014629.
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      46. Chevallier NL, Soriano S, Kang DE, Masliah E, Hu G, Koo E. Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. Am J Pathol. 2005 Jul; 167(1):151-9. PMID: 15972961; PMCID: PMC1603433.
      47. Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo E, Hyman BT, Pietrzik CU, Berezovska O. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem. 2005 Jul 22; 280(29):27303-9. PMID: 15917251.
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      48. Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo E, Golde TE. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nat Med. 2005 May; 11(5):545-50. PMID: 15834426.
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      49. Yoon IS, Pietrzik CU, Kang DE, Koo E. Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. J Biol Chem. 2005 May 20; 280(20):20140-7. PMID: 15772078.
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      50. Sodhi CP, Rampalli S, Perez RG, Koo E, Quinn B, Gottardi-Littell NR. The endocytotic pathway is required for increased A beta 42 secretion during apoptosis. Brain Res Mol Brain Res. 2004 Sep 28; 128(2):201-11. PMID: 15363895.
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      51. Koo E, Kopan R. Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat Med. 2004 Jul; 10 Suppl:S26-33. PMID: 15272268.
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      52. Pietrzik CU, Yoon IS, Jaeger S, Busse T, Weggen S, Koo E. FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci. 2004 Apr 28; 24(17):4259-65. PMID: 15115822.
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      53. Lu DC, Shaked GM, Masliah E, Bredesen DE, Koo E. Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Ann Neurol. 2003 Dec; 54(6):781-9. PMID: 14681887.
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      54. Lu DC, Soriano S, Bredesen DE, Koo E. Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem. 2003 Nov; 87(3):733-41. PMID: 14535955.
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      55. Sagi SA, Weggen S, Eriksen J, Golde TE, Koo E. The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production. J Biol Chem. 2003 Aug 22; 278(34):31825-30. PMID: 12805355.
        View in: PubMed
      56. Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo E. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem. 2003 Aug 22; 278(34):31831-7. PMID: 12805356.
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      57. Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Golde TE, Koo E. Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem. 2003 Aug 15; 278(33):30748-54. PMID: 12777371.
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      58. Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo E, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y. Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. J Biol Chem. 2003 Jul 04; 278(27):24294-301. PMID: 12707272.
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      59. Koo E. The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog? Traffic. 2002 Nov; 3(11):763-70. PMID: 12383342.
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      60. Pietrzik CU, Busse T, Merriam DE, Weggen S, Koo E. The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO J. 2002 Nov 01; 21(21):5691-700. PMID: 12411487; PMCID: PMC131065.
      61. Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo E, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis. 2002 Oct; 11(1):64-82. PMID: 12460547.
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      62. Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo E. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell. 2002 Sep 20; 110(6):751-62. PMID: 12297048.
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      63. Baek SH, Ohgi KA, Rose DW, Koo E, Glass CK, Rosenfeld MG. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell. 2002 Jul 12; 110(1):55-67. PMID: 12150997.
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      64. Galvan V, Chen S, Lu D, Logvinova A, Goldsmith P, Koo E, Bredesen DE. Caspase cleavage of members of the amyloid precursor family of proteins. J Neurochem. 2002 Jul; 82(2):283-94. PMID: 12124429.
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      65. Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo E, Zheng H. The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8760-5. PMID: 12070348; PMCID: PMC124372.