Robert Wechsler-Reya
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Title(s) | Adjunct Professor, Pediatrics |
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School | Health Sciences |
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Address | 9500 Gilman Drive #0831 La Jolla CA 92093
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vCard | Download vCard |
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Research Bibliographic
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Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab002.
Chan TSY, Picard D, Hawkins CE, Lu M, Pfister S, Korshunov A, Roussel MF, Wechsler-Reya RJ, Henkin J, Bouffet E, Huang A. PMID: 33629064.
View in: PubMed Mentions:
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Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma. Sci Transl Med. 2021 Jan 20; 13(577).
Endersby R, Whitehouse J, Pribnow A, Kuchibhotla M, Hii H, Carline B, Gande S, Stripay J, Ancliffe M, Howlett M, Schoep T, George C, Andradas C, Dyer P, Schluck M, Patterson B, Tacheva-Gigorova SK, Cooper MN, Robinson G, Stewart C, Pfister SM, Kool M, Milde T, Gajjar A, Johns T, Wechsler-Reya RJ, Roussel MF, Gottardo NG. PMID: 33472956.
View in: PubMed Mentions: 1 Fields:
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Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor. Mol Ther Oncolytics. 2021 Mar 26; 20:265-276.
Dash RC, Wen J, Zaino AM, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 33614910.
View in: PubMed Mentions:
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Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma. Cancer Res. 2020 Dec 01; 80(23):5393-5407.
Rusert JM, Juarez EF, Brabetz S, Jensen J, Garancher A, Chau LQ, Tacheva-Grigorova SK, Wahab S, Udaka YT, Finlay D, Seker-Cin H, Reardon B, Gröbner S, Serrano J, Ecker J, Qi L, Kogiso M, Du Y, Baxter PA, Henderson JJ, Berens ME, Vuori K, Milde T, Cho YJ, Li XN, Olson JM, Reyes I, Snuderl M, Wong TC, Dimmock DP, Nahas SA, Malicki D, Crawford JR, Levy ML, Van Allen EM, Pfister SM, Tamayo P, Kool M, Mesirov JP, Wechsler-Reya RJ. PMID: 33046443.
View in: PubMed Mentions: Fields:
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Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma. Neuro Oncol. 2020 Aug 21.
Ecker J, Thatikonda V, Sigismondo G, Selt F, Valinciute G, Oehme I, Müller C, Buhl JL, Ridinger J, Usta D, Qin N, van Tilburg CM, Herold-Mende C, Remke M, Sahm F, Westermann F, Kool M, Wechsler-Reya RJ, Chavez L, Krijgsveld J, Jäger N, Pfister SM, Witt O, Milde T. PMID: 32822486.
View in: PubMed Mentions: Fields:
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NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma. Cell Rep. 2020 06 23; 31(12):107782.
Cheng Y, Liao S, Xu G, Hu J, Guo D, Du F, Contreras A, Cai KQ, Peri S, Wang Y, Corney DC, Noronha AM, Chau LQ, Zhou G, Wiest DL, Bellacosa A, Wechsler-Reya RJ, Zhao Y, Yang ZJ. PMID: 32579914.
View in: PubMed Mentions: 1 Fields:
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Characterization of G-CSF receptor expression in medulloblastoma. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa062.
Paul MR, Huo Y, Liu A, Lesperance J, Garancher A, Wechsler-Reya RJ, Zage PE. PMID: 32642714.
View in: PubMed Mentions:
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Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma. Nat Neurosci. 2020 07; 23(7):842-853.
Garancher A, Suzuki H, Haricharan S, Chau LQ, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, Cavalli FMG, Farooq H, Ramaswamy V, Jones SJM, Moore RA, Mungall AJ, Ma Y, Thiessen N, Li Y, Morcavallo A, Qi L, Kogiso M, Du Y, Baxter P, Henderson JJ, Crawford JR, Levy ML, Olson JM, Cho YJ, Deshpande AJ, Li XN, Chesler L, Marra MA, Wajant H, Becher OJ, Bradley LM, Ware CF, Taylor MD, Wechsler-Reya RJ. PMID: 32424282.
View in: PubMed Mentions: 2 Fields: Translation: Animals
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Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin avß5 Axis. Cell Stem Cell. 2020 02 06; 26(2):187-204.e10.
Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038.
View in: PubMed Mentions: 9 Fields:
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Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy. Cell Stem Cell. 2019 Dec 05; 25(6):855-870.e11.
Cancer M, Hutter S, Holmberg KO, Rosén G, Sundström A, Tailor J, Bergström T, Garancher A, Essand M, Wechsler-Reya RJ, Falk A, Weishaupt H, Swartling FJ. PMID: 31786016.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Biallelic loss of GNAS in a patient with pediatric medulloblastoma. Cold Spring Harb Mol Case Stud. 2019 10; 5(5).
Tokita MJ, Nahas S, Briggs B, Malicki DM, Mesirov JP, Reyes IAC, Farnaes L, Levy ML, Kingsmore SF, Dimmock D, Crawford JR, Wechsler-Reya RJ. PMID: 31624069.
View in: PubMed Mentions: Fields: Translation: Humans
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Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature. 2019 10; 574(7780):707-711.
Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Jouvet A, Fèvre-Montange M, Garrè ML, Nageswara Rao AA, Giannini C, Kros JM, French PJ, Jabado N, Ng HK, Poon WS, Eberhart CG, Pollack IF, Olson JM, Weiss WA, Kumabe T, López-Aguilar E, Lach B, Massimino M, Van Meir EG, Rubin JB, Vibhakar R, Chambless LB, Kijima N, Klekner A, Bognár L, Chan JA, Faria CC, Ragoussis J, Pfister SM, Goldenberg A, Wechsler-Reya RJ, Bailey SD, Garzia L, Morrissy AS, Marra MA, Huang X, Malkin D, Ayrault O, Ramaswamy V, Puente XS, Calarco JA, Stein L, Taylor MD. PMID: 31664194.
View in: PubMed Mentions: 15 Fields: Translation: HumansCells
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Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. PLoS One. 2019; 14(9):e0214901.
Chahal KK, Li J, Kufareva I, Parle M, Durden DL, Wechsler-Reya RJ, Chen CC, Abagyan R. PMID: 31539380.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice. Sci Rep. 2019 08 29; 9(1):12587.
Householder KT, Dharmaraj S, Sandberg DI, Wechsler-Reya RJ, Sirianni RW. PMID: 31467368.
View in: PubMed Mentions: 8 Fields: Translation: Animals
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Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. 2019 08; 572(7767):74-79.
Hovestadt V, Smith KS, Bihannic L, Filbin MG, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, Phoenix TN, Hadley JL, Tong Y, Houston J, Ashmun RA, DeCuypere M, Sharma T, Flasch D, Silkov A, Ligon KL, Pomeroy SL, Rivera MN, Rozenblatt-Rosen O, Rusert JM, Wechsler-Reya RJ, Li XN, Peyrl A, Gojo J, Kirchhofer D, Lötsch D, Czech T, Dorfer C, Haberler C, Geyeregger R, Halfmann A, Gawad C, Easton J, Pfister SM, Regev A, Gajjar A, Orr BA, Slavc I, Robinson GW, Bernstein BE, Suvà ML, Northcott PA. PMID: 31341285.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimalsCells
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Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors. J Med Chem. 2019 04 25; 62(8):3873-3885.
Pace JR, Teske KA, Chau LQ, Dash RC, Zaino AM, Wechsler-Reya RJ, Hadden MK. PMID: 30896941.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma. Cancer Res. 2019 05 01; 79(9):2208-2219.
Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, Malkin D, Ellison DW, VandenBerg SR, Eberhart CG, Sears RC, Roussel MF, Gilbertson RJ, Wechsler-Reya RJ. PMID: 30885981.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors. Cancer Res. 2019 03 01; 79(5):905-917.
Beckmann PJ, Larson JD, Larsson AT, Ostergaard JP, Wagner S, Rahrmann EP, Shamsan GA, Otto GM, Williams RL, Wang J, Lee C, Tschida BR, Das P, Dubuc AM, Moriarity BS, Picard D, Wu X, Rodriguez FJ, Rosemarie Q, Krebs RD, Molan AM, Demer AM, Frees MM, Rizzardi AE, Schmechel SC, Eberhart CG, Jenkins RB, Wechsler-Reya RJ, Odde DJ, Huang A, Taylor MD, Sarver AL, Largaespada DA. PMID: 30674530.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Nat Commun. 2019 01 18; 10(1):332.
Lee C, Rudneva VA, Erkek S, Zapatka M, Chau LQ, Tacheva-Grigorova SK, Garancher A, Rusert JM, Aksoy O, Lea R, Mohammad HP, Wang J, Weiss WA, Grimes HL, Pfister SM, Northcott PA, Wechsler-Reya RJ. PMID: 30659187.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism. Clin Cancer Res. 2019 04 01; 25(7):2305-2313.
Prabhu VV, Madhukar NS, Gilvary C, Kline CLB, Oster S, El-Deiry WS, Elemento O, Doherty F, VanEngelenburg A, Durrant J, Tarapore RS, Deacon S, Charter N, Jung J, Park DM, Gilbert MR, Rusert J, Wechsler-Reya R, Arrillaga-Romany I, Batchelor TT, Wen PY, Oster W, Allen JE. PMID: 30559168.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors. Eur J Med Chem. 2019 Feb 01; 163:320-332.
Teske KA, Dash RC, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 30529635.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. Eur J Med Chem. 2019 Jan 15; 162:495-506.
Maschinot CA, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 30471551.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun. 2018 11 02; 9(1):4651.
Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH. PMID: 30389946.
View in: PubMed Mentions: Fields:
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Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun. 2018 10 08; 9(1):4121.
Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH. PMID: 30297829.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma. Sci Signal. 2018 09 11; 11(547).
Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, Theruvath J, Nitta R, Qi L, Li XN, Li G, Taylor MD, Wechsler-Reya RJ, Pinna LA, Cho YJ, Fuller MT, Elias JE, Scott MP. PMID: 30206138.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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Publisher Correction: N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci. 2018 Aug; 21(8):1139.
PMID: 29880878.
View in: PubMed Mentions: 1 Fields:
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A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018 05 31; 173(6):1549.
Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD. PMID: 29856958.
View in: PubMed Mentions: 7 Fields:
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Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies. Annu Rev Neurosci. 2018 07 08; 41:207-232.
PMID: 29641939.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimals
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NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma. Cancer Cell. 2018 03 12; 33(3):435-449.e6.
PMID: 29533784.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018 02 22; 172(5):1050-1062.e14.
Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD. PMID: 29474906.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci. 2018 02; 21(2):195-206.
PMID: 29335608.
View in: PubMed Mentions: 51 Fields: Translation: AnimalsCells
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PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. Cancer Res. 2017 11 01; 77(21):e62-e66.
PMID: 29092942.
View in: PubMed Mentions: 19 Fields: Translation: HumansAnimals
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Brain Tumor Stem Cells Remain in Play. J Clin Oncol. 2017 07 20; 35(21):2428-2431.
PMID: 28640710.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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Molecular mechanisms and therapeutic targets in pediatric brain tumors. Sci Signal. 2017 Mar 14; 10(470).
PMID: 28292958.
View in: PubMed Mentions: 16 Fields: Translation: HumansCells
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Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo. J Control Release. 2017 05 10; 253:172-182.
PMID: 28263836.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125.
PMID: 28178237.
View in: PubMed Mentions: 89 Fields: Translation: HumansCells
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MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. Cancer Cell. 2017 02 13; 31(2):270-285.
PMID: 28089889.
View in: PubMed Mentions: 79 Fields: Translation: HumansAnimals
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Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic. J Med Chem. 2016 04 28; 59(8):3635-49.
PMID: 27014922.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nat Cell Biol. 2016 Apr; 18(4):418-30.
PMID: 26999738.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimalsCells
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HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma. Cancer Cell. 2016 Mar 14; 29(3):311-323.
PMID: 26977882.
View in: PubMed Mentions: 55 Fields: Translation: HumansAnimals
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Divergent clonal selection dominates medulloblastoma at recurrence. Nature. 2016 Jan 21; 529(7586):351-7.
PMID: 26760213.
View in: PubMed Mentions: 80 Fields: Translation: HumansAnimalsCells
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Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer. Cancer Res. 2015 Dec 15; 75(24):5176-5186.
PMID: 26627009.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimals
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Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma. Clin Cancer Res. 2016 Feb 01; 22(3):582-95.
PMID: 26405194.
View in: PubMed Mentions: 26 Fields: Translation: AnimalsCells
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Proteomic profiling of high risk medulloblastoma reveals functional biology. Oncotarget. 2015 Jun 10; 6(16):14584-95.
PMID: 25970789.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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Cancer. For pediatric glioma, leave no histone unturned. Science. 2014 Dec 19; 346(6216):1458-9.
PMID: 25525232.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development. PLoS One. 2014; 9(12):e114433.
PMID: 25493560.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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SnapShot: Medulloblastoma. Cancer Cell. 2014 Dec 08; 26(6):940-940.e1.
PMID: 25490452.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimals
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Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. Oncogene. 2015 Jul; 34(29):3770-9.
PMID: 25241898.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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The G protein a subunit Gas is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nat Med. 2014 Sep; 20(9):1035-42.
PMID: 25150496.
View in: PubMed Mentions: 50 Fields: Translation: HumansCells
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Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat Med. 2014 Jul; 20(7):732-40.
PMID: 24973920.
View in: PubMed Mentions: 95 Fields: Translation: AnimalsCells
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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature. 2014 Jul 24; 511(7510):428-34.
PMID: 25043047.
View in: PubMed Mentions: 133 Fields: Translation: HumansAnimalsCells
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Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature. 2014 Jun 26; 510(7506):537-41.
PMID: 24847876.
View in: PubMed Mentions: 138 Fields: Translation: HumansAnimalsCells
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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell. 2014 Mar 17; 25(3):393-405.
PMID: 24651015.
View in: PubMed Mentions: 205 Fields: Translation: HumansAnimalsCells
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Cytogenetic prognostication within medulloblastoma subgroups. J Clin Oncol. 2014 Mar 20; 32(9):886-96.
PMID: 24493713.
View in: PubMed Mentions: 79 Fields: Translation: HumansCells
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Independently specified Atoh1 domains define novel developmental compartments in rhombomere 1. Development. 2014 Jan; 141(2):389-98.
PMID: 24381197.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer Res. 2014 Feb 15; 20(4):912-25.
PMID: 24297863.
View in: PubMed Mentions: 115 Fields: Translation: HumansAnimalsCells
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TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. Acta Neuropathol. 2013 Dec; 126(6):917-29.
PMID: 24174164.
View in: PubMed Mentions: 59 Fields: Translation: HumansCells
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A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity. Nat Neurosci. 2013 Dec; 16(12):1737-44.
PMID: 24141309.
View in: PubMed Mentions: 39 Fields: Translation: HumansAnimalsCells
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Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases. Cancer Res. 2013 Oct 15; 73(20):6310-22.
PMID: 24067506.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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The role of stem cells and progenitors in the genesis of medulloblastoma. Exp Neurol. 2014 Oct; 260:69-73.
PMID: 23178582.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma. Oncogene. 2013 Aug 29; 32(35):4181-8.
PMID: 23045271.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 2012 Aug 02; 488(7409):49-56.
PMID: 22832581.
View in: PubMed Mentions: 293 Fields: Translation: HumansCells
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Review: personalized mice: modelling the molecular heterogeneity of medulloblastoma. Neuropathol Appl Neurobiol. 2012 Jun; 38(3):228-40.
PMID: 22070547.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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Matching mice to malignancy: molecular subgroups and models of medulloblastoma. Childs Nerv Syst. 2012 Apr; 28(4):521-32.
PMID: 22315164.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimals
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WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development. 2012 May; 139(10):1724-33.
PMID: 22461560.
View in: PubMed Mentions: 42 Fields: Translation: AnimalsCells
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An animal model of MYC-driven medulloblastoma. Cancer Cell. 2012 Feb 14; 21(2):155-67.
PMID: 22340590.
View in: PubMed Mentions: 115 Fields: Translation: AnimalsCells
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Spheres without influence: dissociating in vitro self-renewal from tumorigenic potential in glioma. Cancer Cell. 2012 Jan 17; 21(1):1-3.
PMID: 22264781.
View in: PubMed Mentions: 5 Fields:
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CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma. Cancer Res. 2012 Jan 01; 72(1):122-32.
PMID: 22052462.
View in: PubMed Mentions: 23 Fields: Translation: Animals
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A malignant oligarchy: progenitors govern the behavior of oligodendrogliomas. Cancer Cell. 2010 Dec 14; 18(6):546-7.
Pei Y, Wechsler-Reya RJ. PMID: 21156279.
View in: PubMed Mentions: 3 Fields:
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Subtypes of medulloblastoma have distinct developmental origins. Nature. 2010 Dec 23; 468(7327):1095-9.
Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ. PMID: 21150899.
View in: PubMed Mentions: 283 Fields: Translation: HumansAnimals
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Defining future directions in spinal cord tumor research: proceedings from the National Institutes of Health workshop. J Neurosurg Spine. 2010 Feb; 12(2):117-21.
Claus EB, Abdel-Wahab M, Burger PC, Engelhard HH, Ellison DW, Gaiano N, Gutmann DH, Heck DA, Holland EC, Jallo GI, Kruchko C, Kun LE, Maria BL, Rumboldt Z, Seminara D, Spinella GM, Stophel L, Wechsler-Reya R, Wrensch M, Gilbertson RJ. PMID: 20121344.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimals
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Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell. 2009 Feb 03; 15(2):135-47.
Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, Febbo PG, Wechsler-Reya RJ. PMID: 19185848.
View in: PubMed Mentions: 136 Fields: Translation: HumansAnimalsCells
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N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. Genes Dev. 2009 Jan 15; 23(2):157-70.
Kessler JD, Hasegawa H, Brun SN, Emmenegger BA, Yang ZJ, Dutton JW, Wang F, Wechsler-Reya RJ. PMID: 19171780.
View in: PubMed Mentions: 36 Fields: Translation: AnimalsCells
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Stem cells and the origin and propagation of brain tumors. J Child Neurol. 2008 Oct; 23(10):1172-8.
Emmenegger BA, Wechsler-Reya RJ. PMID: 18952583.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell. 2008 Aug 12; 14(2):135-45.
Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ, Wechsler-Reya RJ. PMID: 18691548.
View in: PubMed Mentions: 265 Fields: Translation: HumansAnimalsCells
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Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20820-5.
Johnson CE, Huang YY, Parrish AB, Smith MI, Vaughn AE, Zhang Q, Wright KM, Van Dyke T, Wechsler-Reya RJ, Kornbluth S, Deshmukh M. PMID: 18093951.
View in: PubMed Mentions: 22 Fields: Translation: HumansCells
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Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2973-8.
Fogarty MP, Emmenegger BA, Grasfeder LL, Oliver TG, Wechsler-Reya RJ. PMID: 17299056.
View in: PubMed Mentions: 51 Fields: Translation: HumansAnimalsCells
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Hit 'em where they live: targeting the cancer stem cell niche. Cancer Cell. 2007 Jan; 11(1):3-5.
Yang ZJ, Wechsler-Reya RJ. PMID: 17222787.
View in: PubMed Mentions: 36 Fields: Translation: HumansAnimalsCells
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Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol Cell Biol. 2006 Oct; 26(20):7550-60.
Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG. PMID: 16908539.
View in: PubMed Mentions: 51 Fields: Translation: HumansAnimalsCells
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The neurobiology of neurooncology. Ann Neurol. 2006 Jul; 60(1):3-11.
Read TA, Hegedus B, Wechsler-Reya R, Gutmann DH. PMID: 16802285.
View in: PubMed Mentions: 15 Fields: Translation: Humans
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Morphing into cancer: the role of developmental signaling pathways in brain tumor formation. J Neurobiol. 2005 Sep 15; 64(4):458-75.
Fogarty MP, Kessler JD, Wechsler-Reya RJ. PMID: 16041741.
View in: PubMed Mentions: 35 Fields: Translation: HumansAnimalsCells
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Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci. 2005 Jun; 8(6):723-9.
Lee A, Kessler JD, Read TA, Kaiser C, Corbeil D, Huttner WB, Johnson JE, Wechsler-Reya RJ. PMID: 15908947.
View in: PubMed Mentions: 166 Fields: Translation: AnimalsCells
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Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. Development. 2005 May; 132(10):2425-39.
Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM, Wechsler-Reya RJ. PMID: 15843415.
View in: PubMed Mentions: 100 Fields: Translation: AnimalsCells
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Getting at the root and stem of brain tumors. Neuron. 2004 Jun 24; 42(6):885-8.
Oliver TG, Wechsler-Reya RJ. PMID: 15207233.
View in: PubMed Mentions: 18 Fields: Translation: HumansAnimalsCells
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Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7331-6.
Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP, Wechsler-Reya RJ. PMID: 12777630.
View in: PubMed Mentions: 127 Fields: Translation: AnimalsCells
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Analysis of gene expression in the normal and malignant cerebellum. Recent Prog Horm Res. 2003; 58:227-48.
Wechsler-Reya RJ. PMID: 12795421.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Caught in the matrix: how vitronectin controls neuronal differentiation. Trends Neurosci. 2001 Dec; 24(12):680-2.
Wechsler-Reya RJ. PMID: 11718852.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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The developmental biology of brain tumors. Annu Rev Neurosci. 2001; 24:385-428.
Wechsler-Reya R, Scott MP. PMID: 11283316.
View in: PubMed Mentions: 140 Fields: Translation: HumansAnimals
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Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. Genes Chromosomes Cancer. 2000 May; 28(1):77-81.
Zurawel RH, Allen C, Wechsler-Reya R, Scott MP, Raffel C. PMID: 10738305.
View in: PubMed Mentions: 41 Fields: Translation: Animals
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Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity. Int J Cancer. 2000 Feb 01; 85(3):376-83.
Ge K, Duhadaway J, Sakamuro D, Wechsler-Reya R, Reynolds C, Prendergast GC. PMID: 10652430.
View in: PubMed Mentions: 23 Fields: Translation: HumansCells
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Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron. 1999 Jan; 22(1):103-14.
Wechsler-Reya RJ, Scott MP. PMID: 10027293.
View in: PubMed Mentions: 449 Fields: Translation: AnimalsCells
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A role for the putative tumor suppressor Bin1 in muscle cell differentiation. Mol Cell Biol. 1998 Jan; 18(1):566-75.
Wechsler-Reya RJ, Elliott KJ, Prendergast GC. PMID: 9418903.
View in: PubMed Mentions: 40 Fields: Translation: HumansAnimalsCells
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Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. J Biol Chem. 1997 Dec 12; 272(50):31453-8.
Wechsler-Reya R, Sakamuro D, Zhang J, Duhadaway J, Prendergast GC. PMID: 9395479.
View in: PubMed Mentions: 42 Fields: Translation: HumansAnimalsCells
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The putative tumor suppressor BIN1 is a short-lived nuclear phosphoprotein, the localization of which is altered in malignant cells. Cancer Res. 1997 Aug 01; 57(15):3258-63.
Wechsler-Reya R, Elliott K, Herlyn M, Prendergast GC. PMID: 9242458.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Retinal development: communication helps you see the light. Curr Biol. 1997 Jul 01; 7(7):R433-6.
Wechsler-Reya RJ, Barres BA. PMID: 9210366.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Lipopolysaccharide prevents apoptosis and induces responsiveness to antigen receptor cross-linking in immature B cells. Immunology. 1996 Nov; 89(3):356-62.
Wechsler-Reya RJ, Monroe JG. PMID: 8958047.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet. 1996 Sep; 14(1):69-77.
Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC. PMID: 8782822.
View in: PubMed Mentions: 97 Fields: Translation: HumansAnimalsCells
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Immature stage B cells enter but do not progress beyond the early G1 phase of the cell cycle in response to antigen receptor signaling. J Immunol. 1996 Jun 15; 156(12):4562-9.
Carman JA, Wechsler-Reya RJ, Monroe JG. PMID: 8648097.
View in: PubMed Mentions: 15 Fields: Translation: AnimalsCells
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Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors. Cancer Res. 1996 Jun 01; 56(11):2626-32.
Prendergast GC, Davide JP, Lebowitz PF, Wechsler-Reya R, Kohl NE. PMID: 8653708.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. Genomics. 1996 Apr 15; 33(2):329-31.
Negorev D, Riethman H, Wechsler-Reya R, Sakamuro D, Prendergast GC, Simon D. PMID: 8725406.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
This graph shows the total number of publications by year. To see the data as text, click here.
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Year | Publications |
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1996 | 5 | 1997 | 3 | 1998 | 1 | 1999 | 1 | 2000 | 2 | 2001 | 2 | 2003 | 2 | 2004 | 1 | 2005 | 3 | 2006 | 2 | 2007 | 3 | 2008 | 2 | 2009 | 2 | 2010 | 3 | 2011 | 1 | 2012 | 8 | 2013 | 4 | 2014 | 11 | 2015 | 3 | 2016 | 4 | 2017 | 6 | 2018 | 12 | 2019 | 10 | 2020 | 6 | 2021 | 3 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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