Robert Wechsler-reya

Title(s)Adjunct Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Identifying and Targeting the Drivers of Pediatric Brain Tumors
    NIH R35NS122339May 1, 2021 - Apr 30, 2029
    Role: Principal Investigator
    Optimization and Characterization of MYC Degraders for Pediatric Medulloblastoma
    NIH R61NS116191May 15, 2020 - Apr 30, 2022
    Role: Co-Principal Investigator
    Regulation of Medulloblastoma Metastasis by Emp1
    NIH R01NS096368Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Mouse models to discover new drivers of medulloblastoma
    NIH R01CA159859Apr 4, 2011 - Jan 31, 2022
    Role: Co-Principal Investigator
    Identification of a Mitogen for Neuronal Progenitors in the Embryonic Cerebellum
    NIH R03NS067362Sep 15, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Stem Cells, Progenitors, and the Origin of Medulloblastoma
    NIH R01CA122759Apr 1, 2009 - Jan 31, 2014
    Role: Principal Investigator
    Control of Medulloblastoma Migration &Survival by Unc5c
    NIH R01NS052323Jun 1, 2006 - May 31, 2011
    Role: Principal Investigator
    Control of Cerebellar Development by FGF signaling
    NIH R01MH067916Dec 17, 2003 - Nov 30, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma. Neuro Oncol. 2024 Oct 12. Gallitto M, Zhang X, De Los Santos G, Wei HJ, Fernández EC, Duan S, Sedor G, Yoh N, Kokosi D, Angel JC, Wang YF, White E, Kinslow CJ, Berg X, Tomassoni L, Zandkarimi F, Chio IIC, Canoll PD, Bruce JN, Feldstein NA, Gartrell RD, Cheng S, Garvin JH, Zacharoulis S, Wechsler-Reya RJ, Pavisic J, Califano A, Zhang Z, Wu CC. PMID: 39394920.
      View in: PubMed   Mentions:    Fields:    
    2. Thyroid hormone suppresses medulloblastoma progression through promoting terminal differentiation of tumor cells. Cancer Cell. 2024 Aug 12; 42(8):1434-1449.e5. Yang Y, Valdés-Rives SA, Liu Q, Gao T, Burudpakdee C, Li Y, Tan J, Tan Y, Koch CA, Rong Y, Houser SR, Wei S, Cai KQ, Wu J, Cheng SY, Wechsler-Reya R, Yang ZJ. PMID: 39137728.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma. Cell. 2024 Aug 22; 187(17):4733-4750.e26. Visvanathan A, Saulnier O, Chen C, Haldipur P, Orisme W, Delaidelli A, Shin S, Millman J, Bryant A, Abeysundara N, Wu X, Hendrikse LD, Patil V, Bashardanesh Z, Golser J, Livingston BG, Nakashima T, Funakoshi Y, Ong W, Rasnitsyn A, Aldinger KA, Richman CM, Van Ommeren R, Lee JJY, Ly M, Vladoiu MC, Kharas K, Balin P, Erickson AW, Fong V, Zhang J, Suárez RA, Wang H, Huang N, Pallota JG, Douglas T, Haapasalo J, Razavi F, Silvestri E, Sirbu O, Worme S, Kameda-Smith MM, Wu X, Daniels C, MichaelRaj AK, Bhaduri A, Schramek D, Suzuki H, Garzia L, Ahmed N, Kleinman CL, Stein LD, Dirks P, Dunham C, Jabado N, Rich JN, Li W, Sorensen PH, Wechsler-Reya RJ, Weiss WA, Millen KJ, Ellison DW, Dimitrov DS, Taylor MD. PMID: 38971152.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. The Virtual Child. Cancer Discov. 2024 Apr 04; 14(4):663-668. Gilbertson RJ, Behjati S, Böttcher AL, Bronner ME, Burridge M, Clausing H, Clifford H, Danaher T, Donovan LK, Drost J, Eggermont AMM, Emerson C, Flores MG, Hamerlik P, Jabado N, Jones A, Kaessmann H, Kleinman CL, Kool M, Kutscher LM, Lindberg G, Linnane E, Marioni JC, Maris JM, Monje M, Macaskill A, Niederer S, Northcott PA, Peeters E, Plieger-van Solkema W, Preußner L, Rios AC, Rippe K, Sandford P, Sgourakis NG, Shlien A, Smith P, Straathof K, Sullivan PJ, Suvà ML, Taylor MD, Thompson E, Vento-Tormo R, Wainwright BJ, Wechsler-Reya RJ, Westermann F, Winslade S, Al-Lazikani B, Pfister SM. PMID: 38571421.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Elucidation and Pharmacologic Targeting of Master Regulator Dependencies in Coexisting Diffuse Midline Glioma Subpopulations. bioRxiv. 2024 Mar 17. Fernández EC, Tomassoni L, Zhang X, Wang J, Obradovic A, Laise P, Griffin AT, Vlahos L, Minns HE, Morales DV, Simmons C, Gallitto M, Wei HJ, Martins TJ, Becker PS, Crawford JR, Tzaridis T, Wechsler-Reya RJ, Garvin J, Gartrell RD, Szalontay L, Zacharoulis S, Wu CC, Zhang Z, Califano A, Pavisic J. PMID: 38559080; PMCID: PMC10979998.
      View in: PubMed   Mentions:
    6. Just a spoonful of metformin helps the medicine go down. J Clin Invest. 2024 Mar 15; 134(6). Tzaridis T, Wechsler-Reya RJ. PMID: 38488006; PMCID: PMC10940077.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. A therapeutically targetable positive feedback loop between lnc-HLX-2-7, HLX, and MYC that promotes group 3 medulloblastoma. Cell Rep. 2024 Mar 26; 43(3):113938. Katsushima K, Joshi K, Yuan M, Romero B, Batish M, Stapleton S, Jallo G, Kolanthai E, Seal S, Saulnier O, Taylor MD, Wechsler-Reya RJ, Eberhart CG, Perera RJ. PMID: 38460130; PMCID: PMC11372658.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Thyroid Hormone Suppresses Medulloblastoma Progression Through Promoting Terminal Differentiation of Tumor Cells. bioRxiv. 2024 Feb 15. Yang Y, Valdés-Rives SA, Liu Q, Li Y, Tan J, Tan Y, Koch CA, Rong Y, Houser SR, Wei S, Cai KQ, Cheng SY, Curran T, Wechsler-Reya R, Yang ZJ. PMID: 38405864; PMCID: PMC10888774.
      View in: PubMed   Mentions:
    9. Developmental basis of SHH medulloblastoma heterogeneity. Nat Commun. 2024 Jan 08; 15(1):270. Gold MP, Ong W, Masteller AM, Ghasemi DR, Galindo JA, Park NR, Huynh NC, Donde A, Pister V, Saurez RA, Vladoiu MC, Hwang GH, Eisemann T, Donovan LK, Walker AD, Benetatos J, Dufour C, Garzia L, Segal RA, Wechsler-Reya RJ, Mesirov JP, Korshunov A, Pajtler KW, Pomeroy SL, Ayrault O, Davidson SM, Cotter JA, Taylor MD, Fraenkel E. PMID: 38191555; PMCID: PMC10774283.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4. Acta Neuropathol Commun. 2023 12 19; 11(1):203. Yuan M, Mahmud I, Katsushima K, Joshi K, Saulnier O, Pokhrel R, Lee B, Liyanage W, Kunhiraman H, Stapleton S, Gonzalez-Gomez I, Kannan RM, Eisemann T, Kolanthai E, Seal S, Garrett TJ, Abbasi S, Bockley K, Hanes J, Chapagain P, Jallo G, Wechsler-Reya RJ, Taylor MD, Eberhart CG, Ray A, Perera RJ. PMID: 38115140; PMCID: PMC10729563.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell. 2024 01 08; 42(1):1-5. Koschmann C, Al-Holou WN, Alonso MM, Anastas J, Bandopadhayay P, Barron T, Becher O, Cartaxo R, Castro MG, Chung C, Clausen M, Dang D, Doherty R, Duchatel R, Dun M, Filbin M, Franson A, Galban S, Garcia Moure M, Garton H, Gowda P, Marques JG, Hawkins C, Heath A, Hulleman E, Ji S, Jones C, Kilburn L, Kline C, Koldobskiy MA, Lim D, Lowenstein PR, Lu QR, Lum J, Mack S, Magge S, Marini B, Martin D, Marupudi N, Messinger D, Mody R, Morgan M, Mota M, Muraszko K, Mueller S, Natarajan SK, Nazarian J, Niculcea M, Nuechterlein N, Okada H, Opipari V, Pai MP, Pal S, Peterson E, Phoenix T, Prensner JR, Pun M, Raju GP, Reitman ZJ, Resnick A, Rogawski D, Saratsis A, Sbergio SG, Souweidane M, Stafford JM, Tzaridis T, Venkataraman S, Vittorio O, Wadden J, Wahl D, Wechsler-Reya RJ, Yadav VN, Zhang X, Zhang Q, Venneti S. PMID: 38039965; PMCID: PMC11067690.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. Nat Genet. 2023 Dec; 55(12):2189-2199. Chapman OS, Luebeck J, Sridhar S, Wong IT, Dixit D, Wang S, Prasad G, Rajkumar U, Pagadala MS, Larson JD, He BJ, Hung KL, Lange JT, Dehkordi SR, Chandran S, Adam M, Morgan L, Wani S, Tiwari A, Guccione C, Lin Y, Dutta A, Lo YY, Juarez E, Robinson JT, Korshunov A, Michaels JA, Cho YJ, Malicki DM, Coufal NG, Levy ML, Hobbs C, Scheuermann RH, Crawford JR, Pomeroy SL, Rich JN, Zhang X, Chang HY, Dixon JR, Bagchi A, Deshpande AJ, Carter H, Fraenkel E, Mischel PS, Wechsler-Reya RJ, Bafna V, Mesirov JP, Chavez L. PMID: 37945900; PMCID: PMC10703696.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Central Nervous System Distribution of Panobinostat in Preclinical Models to Guide Dosing for Pediatric Brain Tumors. J Pharmacol Exp Ther. 2023 12; 387(3):315-327. Zhang W, Oh JH, Zhang W, Rathi S, Larson JD, Wechsler-Reya RJ, Sirianni RW, Elmquist WF. PMID: 37827699; PMCID: PMC10658912.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    14. Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer. Cancer Cell. 2023 11 13; 41(11):1989-2005.e9. Rajbhandari N, Hamilton M, Quintero CM, Ferguson LP, Fox R, Schürch CM, Wang J, Nakamura M, Lytle NK, McDermott M, Diaz E, Pettit H, Kritzik M, Han H, Cridebring D, Wen KW, Tsai S, Goggins MG, Lowy AM, Wechsler-Reya RJ, Von Hoff DD, Newman AM, Reya T. PMID: 37802055; PMCID: PMC10836835.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    15. 3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma. Nat Commun. 2023 04 21; 14(1):2300. Okonechnikov K, Camgöz A, Chapman O, Wani S, Park DE, Hübner JM, Chakraborty A, Pagadala M, Bump R, Chandran S, Kraft K, Acuna-Hidalgo R, Reid D, Sikkink K, Mauermann M, Juarez EF, Jenseit A, Robinson JT, Pajtler KW, Milde T, Jäger N, Fiesel P, Morgan L, Sridhar S, Coufal NG, Levy M, Malicki D, Hobbs C, Kingsmore S, Nahas S, Snuderl M, Crawford J, Wechsler-Reya RJ, Davidson TB, Cotter J, Michaiel G, Fleischhack G, Mundlos S, Schmitt A, Carter H, Michealraj KA, Kumar SA, Taylor MD, Rich J, Buchholz F, Mesirov JP, Pfister SM, Ay F, Dixon JR, Kool M, Chavez L. PMID: 37085539; PMCID: PMC10121654.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. The oncogenic circular RNA circ_63706 is a potential therapeutic target in sonic hedgehog-subtype childhood medulloblastomas. Acta Neuropathol Commun. 2023 03 10; 11(1):38. Katsushima K, Pokhrel R, Mahmud I, Yuan M, Murad R, Baral P, Zhou R, Chapagain P, Garrett T, Stapleton S, Jallo G, Bettegowda C, Raabe E, Wechsler-Reya RJ, Eberhart CG, Perera RJ. PMID: 36899402; PMCID: PMC10007801.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    17. Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Nat Commun. 2023 Jan 10; 14(1):136. Kameda-Smith MM, Zhu H, Luo EC, Suk Y, Xella A, Yee B, Chokshi C, Xing S, Tan F, Fox RG, Adile AA, Bakhshinyan D, Brown K, Gwynne WD, Subapanditha M, Miletic P, Picard D, Burns I, Moffat J, Paruch K, Fleming A, Hope K, Provias JP, Remke M, Lu Y, Reya T, Venugopal C, Reimand J, Wechsler-Reya RJ, Yeo GW, Singh SK. PMID: 36627300; PMCID: PMC9832149.
      View in: PubMed   Mentions:    Fields:    
    18. N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma. Cancer Res. 2023 01 04; 83(1):130-140. Kuzuoglu-Ozturk D, Aksoy O, Schmidt C, Lea R, Larson JD, Phelps RRL, Nasholm N, Holt M, Contreras A, Huang M, Wong-Michalak S, Shao H, Wechsler-Reya R, Phillips JJ, Gestwicki JE, Ruggero D, Weiss WA. PMID: 36264168; PMCID: PMC9812901.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    19. Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma. Cancer Res. 2022 12 16; 82(24):4586-4603. Borgenvik A, Holmberg KO, Bolin S, Zhao M, Savov V, Rosén G, Hutter S, Garancher A, Rahmanto AS, Bergström T, Olsen TK, Mainwaring OJ, Sattanino D, Verbaan AD, Rusert JM, Sundström A, Bravo MB, Dang Y, Wenz AS, Richardson S, Fotaki G, Hill RM, Dubuc AM, Kalushkova A, Remke M, Cancer M, Jernberg-Wiklund H, Giraud G, Chen X, Taylor MD, Sangfelt O, Clifford SC, Schüller U, Wechsler-Reya RJ, Weishaupt H, Swartling FJ. PMID: 36219398; PMCID: PMC9755969.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    20. Safety and Efficacy of Intraventricular Immunovirotherapy with Oncolytic HSV-1 for CNS Cancers. Clin Cancer Res. 2022 12 15; 28(24):5419-5430. Kang KD, Bernstock JD, Totsch SK, Gary SE, Rocco A, Nan L, Li R, Etminan T, Han X, Beierle EA, Eisemann T, Wechsler-Reya RJ, Bae S, Whitley R, Gillespie GY, Markert JM, Friedman GK. PMID: 36239623; PMCID: PMC9771977.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    21. Current studies and future directions for medulloblastoma: A review from the pacific pediatric neuro-oncology consortium (PNOC) disease working group. Neoplasia. 2023 01; 35:100861. Cooney T, Lindsay H, Leary S, Wechsler-Reya R. PMID: 36516489; PMCID: PMC9755363.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Nat Commun. 2022 12 06; 13(1):7506. Kameda-Smith MM, Zhu H, Luo EC, Suk Y, Xella A, Yee B, Chokshi C, Xing S, Tan F, Fox RG, Adile AA, Bakhshinyan D, Brown K, Gwynne WD, Subapanditha M, Miletic P, Picard D, Burns I, Moffat J, Paruch K, Fleming A, Hope K, Provias JP, Remke M, Lu Y, Reya T, Venugopal C, Reimand J, Wechsler-Reya RJ, Yeo GW, Singh SK. PMID: 36473869; PMCID: PMC9726987.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    23. Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022 Dec; 612(7940):E12. Hendrikse LD, Haldipur P, Saulnier O, Millman J, Sjoboen AH, Erickson AW, Ong W, Gordon V, Coudière-Morrison L, Mercier AL, Shokouhian M, Suárez RA, Ly M, Borlase S, Scott DS, Vladoiu MC, Farooq H, Sirbu O, Nakashima T, Nambu S, Funakoshi Y, Bahcheli A, Diaz-Mejia JJ, Golser J, Bach K, Phuong-Bao T, Skowron P, Wang EY, Kumar SA, Balin P, Visvanathan A, Lee JJY, Ayoub R, Chen X, Chen X, Mungall KL, Luu B, Bérubé P, Wang YC, Pfister SM, Kim SK, Delattre O, Bourdeaut F, Doz F, Masliah-Planchon J, Grajkowska WA, Loukides J, Dirks P, Fèvre-Montange M, Jouvet A, French PJ, Kros JM, Zitterbart K, Bailey SD, Eberhart CG, Rao AAN, Giannini C, Olson JM, Garami M, Hauser P, Phillips JJ, Ra YS, de Torres C, Mora J, Li KKW, Ng HK, Poon WS, Pollack IF, López-Aguilar E, Gillespie GY, Van Meter TE, Shofuda T, Vibhakar R, Thompson RC, Cooper MK, Rubin JB, Kumabe T, Jung S, Lach B, Iolascon A, Ferrucci V, de Antonellis P, Zollo M, Cinalli G, Robinson S, Stearns DS, Van Meir EG, Porrati P, Finocchiaro G, Massimino M, Carlotti CG, Faria CC, Roussel MF, Boop F, Chan JA, Aldinger KA, Razavi F, Silvestri E, McLendon RE, Thompson EM, Ansari M, Garre ML, Chico F, Eguía P, Pérezpeña M, Morrissy AS, Cavalli FMG, Wu X, Daniels C, Rich JN, Jones SJM, Moore RA, Marra MA, Huang X, Reimand J, Sorensen PH, Wechsler-Reya RJ, Weiss WA, Pugh TJ, Garzia L, Kleinman CL, Stein LD, Jabado N, Malkin D, Ayrault O, Golden JA, Ellison DW, Doble B, Ramaswamy V, Werbowetski-Ogilvie TE, Suzuki H, Millen KJ, Taylor MD. PMID: 36446943; PMCID: PMC10729707.
      View in: PubMed   Mentions: 1     Fields:    
    24. Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022 09; 609(7929):1021-1028. Hendrikse LD, Haldipur P, Saulnier O, Millman J, Sjoboen AH, Erickson AW, Ong W, Gordon V, Coudière-Morrison L, Mercier AL, Shokouhian M, Suárez RA, Ly M, Borlase S, Scott DS, Vladoiu MC, Farooq H, Sirbu O, Nakashima T, Nambu S, Funakoshi Y, Bahcheli A, Diaz-Mejia JJ, Golser J, Bach K, Phuong-Bao T, Skowron P, Wang EY, Kumar SA, Balin P, Visvanathan A, Lee JJY, Ayoub R, Chen X, Chen X, Mungall KL, Luu B, Bérubé P, Wang YC, Pfister SM, Kim SK, Delattre O, Bourdeaut F, Doz F, Masliah-Planchon J, Grajkowska WA, Loukides J, Dirks P, Fèvre-Montange M, Jouvet A, French PJ, Kros JM, Zitterbart K, Bailey SD, Eberhart CG, Rao AAN, Giannini C, Olson JM, Garami M, Hauser P, Phillips JJ, Ra YS, de Torres C, Mora J, Li KKW, Ng HK, Poon WS, Pollack IF, López-Aguilar E, Gillespie GY, Van Meter TE, Shofuda T, Vibhakar R, Thompson RC, Cooper MK, Rubin JB, Kumabe T, Jung S, Lach B, Iolascon A, Ferrucci V, de Antonellis P, Zollo M, Cinalli G, Robinson S, Stearns DS, Van Meir EG, Porrati P, Finocchiaro G, Massimino M, Carlotti CG, Faria CC, Roussel MF, Boop F, Chan JA, Aldinger KA, Razavi F, Silvestri E, McLendon RE, Thompson EM, Ansari M, Garre ML, Chico F, Eguía P, Pérezpeña M, Morrissy AS, Cavalli FMG, Wu X, Daniels C, Rich JN, Jones SJM, Moore RA, Marra MA, Huang X, Reimand J, Sorensen PH, Wechsler-Reya RJ, Weiss WA, Pugh TJ, Garzia L, Kleinman CL, Stein LD, Jabado N, Malkin D, Ayrault O, Golden JA, Ellison DW, Doble B, Ramaswamy V, Werbowetski-Ogilvie TE, Suzuki H, Millen KJ, Taylor MD. PMID: 36131014; PMCID: PMC10026724.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    25. A novel serum extracellular vesicle protein signature to monitor glioblastoma tumor progression. Int J Cancer. 2023 01 15; 152(2):308-319. Tzaridis T, Weller J, Bachurski D, Shakeri F, Schaub C, Hau P, Buness A, Schlegel U, Steinbach JP, Seidel C, Goldbrunner R, Schäfer N, Wechsler-Reya RJ, Hallek M, Scheffler B, Glas M, Haeberle L, Herrlinger U, Coch C, Reiners KS, Hartmann G. PMID: 36054558.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    26. Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors. J Immunother Cancer. 2022 09; 10(9). Foster JB, Griffin C, Rokita JL, Stern A, Brimley C, Rathi K, Lane MV, Buongervino SN, Smith T, Madsen PJ, Martinez D, Delaidelli A, Sorensen PH, Wechsler-Reya RJ, Karikó K, Storm PB, Barrett DM, Resnick AC, Maris JM, Bosse KR. PMID: 36167467; PMCID: PMC9516314.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    27. Subgroup-Enriched Pathways and Kinase Signatures in Medulloblastoma Patient-Derived Xenografts. J Proteome Res. 2022 09 02; 21(9):2124-2136. Leskoske KL, Garcia-Mansfield K, Sharma R, Krishnan A, Rusert JM, Mesirov JP, Wechsler-Reya RJ, Pirrotte P. PMID: 35977718; PMCID: PMC9442791.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    28. The long non-coding RNA SPRIGHTLY and its binding partner PTBP1 regulate exon 5 skipping of SMYD3 transcripts in group 4 medulloblastomas. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac120. Lee B, Katsushima K, Pokhrel R, Yuan M, Stapleton S, Jallo G, Wechsler-Reya RJ, Eberhart CG, Ray A, Perera RJ. PMID: 36267874; PMCID: PMC9569026.
      View in: PubMed   Mentions: 7  
    29. Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression. Commun Biol. 2022 07 14; 5(1):697. Zagozewski J, Borlase S, Guppy BJ, Coudière-Morrison L, Shahriary GM, Gordon V, Liang L, Cheng S, Porter CJ, Kelley R, Hawkins C, Chan JA, Liang Y, Gong J, Nör C, Saulnier O, Wechsler-Reya RJ, Ramaswamy V, Werbowetski-Ogilvie TE. PMID: 35835937; PMCID: PMC9283517.
      View in: PubMed   Mentions: 10  Translation:HumansAnimals
    30. Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma. Genes Dev. 2022 05 01; 36(9-10):514-532. Eisemann T, Wechsler-Reya RJ. PMID: 35680424; PMCID: PMC9186392.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    31. Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development. Cell Death Differ. 2022 08; 29(8):1596-1610. Li Q, Han Z, Singh N, Terré B, Fame RM, Arif U, Page TD, Zahran T, Abdeltawab A, Huang Y, Cao P, Wang J, Lu H, Lidov HGW, Surendran K, Wu L, Virga JQ, Zhao YT, Schüller U, Wechsler-Reya RJ, Lehtinen MK, Roy S, Liu Z, Stracker TH, Zhao H. PMID: 35322202; PMCID: PMC9345885.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    32. Conventional Therapies Deplete Brain-Infiltrating Adaptive Immune Cells in a Mouse Model of Group 3 Medulloblastoma Implicating Myeloid Cells as Favorable Immunotherapy Targets. Front Immunol. 2022; 13:837013. Abbas Z, George C, Ancliffe M, Howlett M, Jones AC, Kuchibhotla M, Wechsler-Reya RJ, Gottardo NG, Endersby R. PMID: 35309309; PMCID: PMC8928748.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    33. Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma. Neuro Oncol. 2022 02 01; 24(2):273-286. Riemondy KA, Venkataraman S, Willard N, Nellan A, Sanford B, Griesinger AM, Amani V, Mitra S, Hankinson TC, Handler MH, Sill M, Ocasio J, Weir SJ, Malawsky DS, Gershon TR, Garancher A, Wechsler-Reya RJ, Hesselberth JR, Foreman NK, Donson AM, Vibhakar R. PMID: 34077540; PMCID: PMC8804892.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
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    118. Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2973-8. Fogarty MP, Emmenegger BA, Grasfeder LL, Oliver TG, Wechsler-Reya RJ. PMID: 17299056; PMCID: PMC1815291.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    119. Hit 'em where they live: targeting the cancer stem cell niche. Cancer Cell. 2007 Jan; 11(1):3-5. Yang ZJ, Wechsler-Reya RJ. PMID: 17222787.
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    120. Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol Cell Biol. 2006 Oct; 26(20):7550-60. Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG. PMID: 16908539; PMCID: PMC1636865.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    121. The neurobiology of neurooncology. Ann Neurol. 2006 Jul; 60(1):3-11. Read TA, Hegedus B, Wechsler-Reya R, Gutmann DH. PMID: 16802285.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    122. Morphing into cancer: the role of developmental signaling pathways in brain tumor formation. J Neurobiol. 2005 Sep 15; 64(4):458-75. Fogarty MP, Kessler JD, Wechsler-Reya RJ. PMID: 16041741.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    123. Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci. 2005 Jun; 8(6):723-9. Lee A, Kessler JD, Read TA, Kaiser C, Corbeil D, Huttner WB, Johnson JE, Wechsler-Reya RJ. PMID: 15908947; PMCID: PMC2377345.
      View in: PubMed   Mentions: 200     Fields:    Translation:AnimalsCells
    124. Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. Development. 2005 May; 132(10):2425-39. Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM, Wechsler-Reya RJ. PMID: 15843415.
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    125. Getting at the root and stem of brain tumors. Neuron. 2004 Jun 24; 42(6):885-8. Oliver TG, Wechsler-Reya RJ. PMID: 15207233.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    126. Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7331-6. Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP, Wechsler-Reya RJ. PMID: 12777630; PMCID: PMC165875.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    127. Analysis of gene expression in the normal and malignant cerebellum. Recent Prog Horm Res. 2003; 58:227-48. Wechsler-Reya RJ. PMID: 12795421.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    128. Caught in the matrix: how vitronectin controls neuronal differentiation. Trends Neurosci. 2001 Dec; 24(12):680-2. Wechsler-Reya RJ. PMID: 11718852.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    129. The developmental biology of brain tumors. Annu Rev Neurosci. 2001; 24:385-428. Wechsler-Reya R, Scott MP. PMID: 11283316.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimals
    130. Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. Genes Chromosomes Cancer. 2000 May; 28(1):77-81. Zurawel RH, Allen C, Wechsler-Reya R, Scott MP, Raffel C. PMID: 10738305.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    131. Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity. Int J Cancer. 2000 Feb 01; 85(3):376-83. Ge K, Duhadaway J, Sakamuro D, Wechsler-Reya R, Reynolds C, Prendergast GC. PMID: 10652430.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    132. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron. 1999 Jan; 22(1):103-14. Wechsler-Reya RJ, Scott MP. PMID: 10027293.
      View in: PubMed   Mentions: 568     Fields:    Translation:AnimalsCells
    133. A role for the putative tumor suppressor Bin1 in muscle cell differentiation. Mol Cell Biol. 1998 Jan; 18(1):566-75. Wechsler-Reya RJ, Elliott KJ, Prendergast GC. PMID: 9418903; PMCID: PMC121524.
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    134. Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. J Biol Chem. 1997 Dec 12; 272(50):31453-8. Wechsler-Reya R, Sakamuro D, Zhang J, Duhadaway J, Prendergast GC. PMID: 9395479.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    135. The putative tumor suppressor BIN1 is a short-lived nuclear phosphoprotein, the localization of which is altered in malignant cells. Cancer Res. 1997 Aug 01; 57(15):3258-63. Wechsler-Reya R, Elliott K, Herlyn M, Prendergast GC. PMID: 9242458.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    136. Retinal development: communication helps you see the light. Curr Biol. 1997 Jul 01; 7(7):R433-6. Wechsler-Reya RJ, Barres BA. PMID: 9210366.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    137. Lipopolysaccharide prevents apoptosis and induces responsiveness to antigen receptor cross-linking in immature B cells. Immunology. 1996 Nov; 89(3):356-62. Wechsler-Reya RJ, Monroe JG. PMID: 8958047; PMCID: PMC1456554.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    138. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet. 1996 Sep; 14(1):69-77. Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC. PMID: 8782822.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    139. Immature stage B cells enter but do not progress beyond the early G1 phase of the cell cycle in response to antigen receptor signaling. J Immunol. 1996 Jun 15; 156(12):4562-9. Carman JA, Wechsler-Reya RJ, Monroe JG. PMID: 8648097.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    140. Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors. Cancer Res. 1996 Jun 01; 56(11):2626-32. Prendergast GC, Davide JP, Lebowitz PF, Wechsler-Reya R, Kohl NE. PMID: 8653708.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    141. The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. Genomics. 1996 Apr 15; 33(2):329-31. Negorev D, Riethman H, Wechsler-Reya R, Sakamuro D, Prendergast GC, Simon D. PMID: 8725406.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
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