Robert Wechsler-reya

Title(s)Adjunct Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Identifying and Targeting the Drivers of Pediatric Brain Tumors
    NIH R35NS122339May 1, 2021 - Apr 30, 2029
    Role: Principal Investigator
    Optimization and Characterization of MYC Degraders for Pediatric Medulloblastoma
    NIH R61NS116191May 15, 2020 - Apr 30, 2022
    Role: Co-Principal Investigator
    Regulation of Medulloblastoma Metastasis by Emp1
    NIH R01NS096368Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Mouse models to discover new drivers of medulloblastoma
    NIH R01CA159859Apr 4, 2011 - Jan 31, 2022
    Role: Co-Principal Investigator
    Identification of a Mitogen for Neuronal Progenitors in the Embryonic Cerebellum
    NIH R03NS067362Sep 15, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Stem Cells, Progenitors, and the Origin of Medulloblastoma
    NIH R01CA122759Apr 1, 2009 - Jan 31, 2014
    Role: Principal Investigator
    Control of Medulloblastoma Migration &Survival by Unc5c
    NIH R01NS052323Jun 1, 2006 - May 31, 2011
    Role: Principal Investigator
    Control of Cerebellar Development by FGF signaling
    NIH R01MH067916Dec 17, 2003 - Nov 30, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression. Commun Biol. 2022 07 14; 5(1):697. Zagozewski J, Borlase S, Guppy BJ, Coudière-Morrison L, Shahriary GM, Gordon V, Liang L, Cheng S, Porter CJ, Kelley R, Hawkins C, Chan JA, Liang Y, Gong J, Nör C, Saulnier O, Wechsler-Reya RJ, Ramaswamy V, Werbowetski-Ogilvie TE. PMID: 35835937; PMCID: PMC9283517.
      View in: PubMed   Mentions: Translation:HumansAnimals
    2. Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma. Genes Dev. 2022 05 01; 36(9-10):514-532. Eisemann T, Wechsler-Reya RJ. PMID: 35680424; PMCID: PMC9186392.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development. Cell Death Differ. 2022 08; 29(8):1596-1610. Li Q, Han Z, Singh N, Terré B, Fame RM, Arif U, Page TD, Zahran T, Abdeltawab A, Huang Y, Cao P, Wang J, Lu H, Lidov HGW, Surendran K, Wu L, Virga JQ, Zhao YT, Schüller U, Wechsler-Reya RJ, Lehtinen MK, Roy S, Liu Z, Stracker TH, Zhao H. PMID: 35322202; PMCID: PMC9345885.
      View in: PubMed   Mentions:    Fields:    
    4. Conventional Therapies Deplete Brain-Infiltrating Adaptive Immune Cells in a Mouse Model of Group 3 Medulloblastoma Implicating Myeloid Cells as Favorable Immunotherapy Targets. Front Immunol. 2022; 13:837013. Abbas Z, George C, Ancliffe M, Howlett M, Jones AC, Kuchibhotla M, Wechsler-Reya RJ, Gottardo NG, Endersby R. PMID: 35309309; PMCID: PMC8928748.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma. Neuro Oncol. 2022 02 01; 24(2):273-286. Riemondy KA, Venkataraman S, Willard N, Nellan A, Sanford B, Griesinger AM, Amani V, Mitra S, Hankinson TC, Handler MH, Sill M, Ocasio J, Weir SJ, Malawsky DS, Gershon TR, Garancher A, Wechsler-Reya RJ, Hesselberth JR, Foreman NK, Donson AM, Vibhakar R. PMID: 34077540; PMCID: PMC8804892.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    6. The current landscape of immunotherapy for pediatric brain tumors. Nat Cancer. 2022 01; 3(1):11-24. Hwang EI, Sayour EJ, Flores CT, Grant G, Wechsler-Reya R, Hoang-Minh LB, Kieran MW, Salcido J, Prins RM, Figg JW, Platten M, Candelario KM, Hale PG, Blatt JE, Governale LS, Okada H, Mitchell DA, Pollack IF. PMID: 35121998.
      View in: PubMed   Mentions: 1  Translation:Humans
    7. Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases. Sci Transl Med. 2022 01 05; 14(626):eabf3917. Dixit D, Prager BC, Gimple RC, Miller TE, Wu Q, Yomtoubian S, Kidwell RL, Lv D, Zhao L, Qiu Z, Zhang G, Lee D, Park DE, Wechsler-Reya RJ, Wang X, Bao S, Rich JN. PMID: 34985972.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma. Nat Neurosci. 2022 01; 25(1):127. Garancher A, Suzuki H, Haricharan S, Chau LQ, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, Cavalli FMG, Farooq H, Ramaswamy V, Jones SJM, Moore RA, Mungall AJ, Ma Y, Thiessen N, Li Y, Morcavallo A, Qi L, Kogiso M, Du Y, Baxter P, Henderson JJ, Crawford JR, Levy ML, Olson JM, Cho YJ, Deshpande AJ, Li XN, Chesler L, Marra MA, Wajant H, Becher OJ, Bradley LM, Ware CF, Taylor MD, Wechsler-Reya RJ. PMID: 34907396; PMCID: PMC8787865.
      View in: PubMed   Mentions:    Fields:    
    9. Integrated genome and tissue engineering enables screening of cancer vulnerabilities in physiologically relevant perfusable ex vivo cultures. Biomaterials. 2022 01; 280:121276. Hu M, Lei XY, Larson JD, McAlonis M, Ford K, McDonald D, Mach K, Rusert JM, Wechsler-Reya RJ, Mali P. PMID: 34890975; PMCID: PMC9328412.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. KITlow Cells Mediate Imatinib Resistance in Gastrointestinal Stromal Tumor. Mol Cancer Ther. 2021 10; 20(10):2035-2048. Banerjee S, Yoon H, Ting S, Tang CM, Yebra M, Wenzel AT, Yeerna H, Mesirov JP, Wechsler-Reya RJ, Tamayo P, Sicklick JK. PMID: 34376580; PMCID: PMC8492542.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML. Blood. 2021 06 17; 137(24):3403-3415. Chen BR, Deshpande A, Barbosa K, Kleppe M, Lei X, Yeddula N, Vela PS, Campos AR, Wechsler-Reya RJ, Bagchi A, Meshinchi S, Eaves C, Jeremias I, Haferlach T, Frank DA, Ronai Z, Chanda S, Armstrong SA, Adams PD, Levine RL, Deshpande AJ. PMID: 33690798; PMCID: PMC8212510.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth. Commun Biol. 2021 05 11; 4(1):552. Qiu R, Wu J, Gudenas B, Northcott PA, Wechsler-Reya RJ, Lu Q. PMID: 33976373; PMCID: PMC8113472.
      View in: PubMed   Mentions: 1  Translation:AnimalsCells
    13. The long noncoding RNA lnc-HLX-2-7 is oncogenic in Group 3 medulloblastomas. Neuro Oncol. 2021 04 12; 23(4):572-585. Katsushima K, Lee B, Kunhiraman H, Zhong C, Murad R, Yin J, Liu B, Garancher A, Gonzalez-Gomez I, Monforte HL, Stapleton S, Vibhakar R, Bettegowda C, Wechsler-Reya RJ, Jallo G, Raabe E, Eberhart CG, Perera RJ. PMID: 33844835; PMCID: PMC8041340.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma. Neuro Oncol. 2021 02 25; 23(2):226-239. Ecker J, Thatikonda V, Sigismondo G, Selt F, Valinciute G, Oehme I, Müller C, Buhl JL, Ridinger J, Usta D, Qin N, van Tilburg CM, Herold-Mende C, Remke M, Sahm F, Westermann F, Kool M, Wechsler-Reya RJ, Chavez L, Krijgsveld J, Jäger N, Pfister SM, Witt O, Milde T. PMID: 32822486; PMCID: PMC7906057.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab002. Chan TSY, Picard D, Hawkins CE, Lu M, Pfister S, Korshunov A, Roussel MF, Wechsler-Reya RJ, Henkin J, Bouffet E, Huang A. PMID: 33629064; PMCID: PMC7890793.
      View in: PubMed   Mentions: 1  
    16. Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma. Sci Transl Med. 2021 01 20; 13(577). Endersby R, Whitehouse J, Pribnow A, Kuchibhotla M, Hii H, Carline B, Gande S, Stripay J, Ancliffe M, Howlett M, Schoep T, George C, Andradas C, Dyer P, Schluck M, Patterson B, Tacheva-Gigorova SK, Cooper MN, Robinson G, Stewart C, Pfister SM, Kool M, Milde T, Gajjar A, Johns T, Wechsler-Reya RJ, Roussel MF, Gottardo NG. PMID: 33472956; PMCID: PMC8994821.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    17. Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor. Mol Ther Oncolytics. 2021 Mar 26; 20:265-276. Dash RC, Wen J, Zaino AM, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 33614910; PMCID: PMC7873571.
      View in: PubMed   Mentions: 3  
    18. Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma. Cancer Res. 2020 12 01; 80(23):5393-5407. Rusert JM, Juarez EF, Brabetz S, Jensen J, Garancher A, Chau LQ, Tacheva-Grigorova SK, Wahab S, Udaka YT, Finlay D, Seker-Cin H, Reardon B, Gröbner S, Serrano J, Ecker J, Qi L, Kogiso M, Du Y, Baxter PA, Henderson JJ, Berens ME, Vuori K, Milde T, Cho YJ, Li XN, Olson JM, Reyes I, Snuderl M, Wong TC, Dimmock DP, Nahas SA, Malicki D, Crawford JR, Levy ML, Van Allen EM, Pfister SM, Tamayo P, Kool M, Mesirov JP, Wechsler-Reya RJ. PMID: 33046443; PMCID: PMC7718387.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma. Cell Rep. 2020 06 23; 31(12):107782. Cheng Y, Liao S, Xu G, Hu J, Guo D, Du F, Contreras A, Cai KQ, Peri S, Wang Y, Corney DC, Noronha AM, Chau LQ, Zhou G, Wiest DL, Bellacosa A, Wechsler-Reya RJ, Zhao Y, Yang ZJ. PMID: 32579914; PMCID: PMC7357167.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. Characterization of G-CSF receptor expression in medulloblastoma. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa062. Paul MR, Huo Y, Liu A, Lesperance J, Garancher A, Wechsler-Reya RJ, Zage PE. PMID: 32642714; PMCID: PMC7316203.
      View in: PubMed   Mentions: 3  
    21. Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma. Nat Neurosci. 2020 07; 23(7):842-853. Garancher A, Suzuki H, Haricharan S, Chau LQ, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, Cavalli FMG, Farooq H, Ramaswamy V, Jones SJM, Moore RA, Mungall AJ, Ma Y, Thiessen N, Li Y, Morcavallo A, Qi L, Kogiso M, Du Y, Baxter P, Henderson JJ, Crawford JR, Levy ML, Olson JM, Cho YJ, Deshpande AJ, Li XN, Chesler L, Marra MA, Wajant H, Becher OJ, Bradley LM, Ware CF, Taylor MD, Wechsler-Reya RJ. PMID: 32424282; PMCID: PMC7456619.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    22. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis. Cell Stem Cell. 2020 02 06; 26(2):187-204.e10. Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    23. Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy. Cell Stem Cell. 2019 Dec 05; 25(6):855-870.e11. Cancer M, Hutter S, Holmberg KO, Rosén G, Sundström A, Tailor J, Bergström T, Garancher A, Essand M, Wechsler-Reya RJ, Falk A, Weishaupt H, Swartling FJ. PMID: 31786016; PMCID: PMC6900751.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    24. Biallelic loss of GNAS in a patient with pediatric medulloblastoma. Cold Spring Harb Mol Case Stud. 2019 10; 5(5). Tokita MJ, Nahas S, Briggs B, Malicki DM, Mesirov JP, Reyes IAC, Farnaes L, Levy ML, Kingsmore SF, Dimmock D, Crawford JR, Wechsler-Reya RJ. PMID: 31624069; PMCID: PMC6824258.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature. 2019 10; 574(7780):707-711. Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Jouvet A, Fèvre-Montange M, Garrè ML, Nageswara Rao AA, Giannini C, Kros JM, French PJ, Jabado N, Ng HK, Poon WS, Eberhart CG, Pollack IF, Olson JM, Weiss WA, Kumabe T, López-Aguilar E, Lach B, Massimino M, Van Meir EG, Rubin JB, Vibhakar R, Chambless LB, Kijima N, Klekner A, Bognár L, Chan JA, Faria CC, Ragoussis J, Pfister SM, Goldenberg A, Wechsler-Reya RJ, Bailey SD, Garzia L, Morrissy AS, Marra MA, Huang X, Malkin D, Ayrault O, Ramaswamy V, Puente XS, Calarco JA, Stein L, Taylor MD. PMID: 31664194; PMCID: PMC7141958.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    26. Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. PLoS One. 2019; 14(9):e0214901. Chahal KK, Li J, Kufareva I, Parle M, Durden DL, Wechsler-Reya RJ, Chen CC, Abagyan R. PMID: 31539380; PMCID: PMC6754133.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    27. Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice. Sci Rep. 2019 08 29; 9(1):12587. Householder KT, Dharmaraj S, Sandberg DI, Wechsler-Reya RJ, Sirianni RW. PMID: 31467368; PMCID: PMC6715675.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    28. Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. 2019 08; 572(7767):74-79. Hovestadt V, Smith KS, Bihannic L, Filbin MG, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, Phoenix TN, Hadley JL, Tong Y, Houston J, Ashmun RA, DeCuypere M, Sharma T, Flasch D, Silkov A, Ligon KL, Pomeroy SL, Rivera MN, Rozenblatt-Rosen O, Rusert JM, Wechsler-Reya RJ, Li XN, Peyrl A, Gojo J, Kirchhofer D, Lötsch D, Czech T, Dorfer C, Haberler C, Geyeregger R, Halfmann A, Gawad C, Easton J, Pfister SM, Regev A, Gajjar A, Orr BA, Slavc I, Robinson GW, Bernstein BE, Suvà ML, Northcott PA. PMID: 31341285; PMCID: PMC6754173.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    29. Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors. J Med Chem. 2019 04 25; 62(8):3873-3885. Pace JR, Teske KA, Chau LQ, Dash RC, Zaino AM, Wechsler-Reya RJ, Hadden MK. PMID: 30896941; PMCID: PMC7450990.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    30. Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma. Cancer Res. 2019 05 01; 79(9):2208-2219. Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, Malkin D, Ellison DW, VandenBerg SR, Eberhart CG, Sears RC, Roussel MF, Gilbertson RJ, Wechsler-Reya RJ. PMID: 30885981; PMCID: PMC6497574.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    31. Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors. Cancer Res. 2019 03 01; 79(5):905-917. Beckmann PJ, Larson JD, Larsson AT, Ostergaard JP, Wagner S, Rahrmann EP, Shamsan GA, Otto GM, Williams RL, Wang J, Lee C, Tschida BR, Das P, Dubuc AM, Moriarity BS, Picard D, Wu X, Rodriguez FJ, Rosemarie Q, Krebs RD, Molan AM, Demer AM, Frees MM, Rizzardi AE, Schmechel SC, Eberhart CG, Jenkins RB, Wechsler-Reya RJ, Odde DJ, Huang A, Taylor MD, Sarver AL, Largaespada DA. PMID: 30674530; PMCID: PMC6397665.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Nat Commun. 2019 01 18; 10(1):332. Lee C, Rudneva VA, Erkek S, Zapatka M, Chau LQ, Tacheva-Grigorova SK, Garancher A, Rusert JM, Aksoy O, Lea R, Mohammad HP, Wang J, Weiss WA, Grimes HL, Pfister SM, Northcott PA, Wechsler-Reya RJ. PMID: 30659187; PMCID: PMC6338772.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    33. Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism. Clin Cancer Res. 2019 04 01; 25(7):2305-2313. Prabhu VV, Madhukar NS, Gilvary C, Kline CLB, Oster S, El-Deiry WS, Elemento O, Doherty F, VanEngelenburg A, Durrant J, Tarapore RS, Deacon S, Charter N, Jung J, Park DM, Gilbert MR, Rusert J, Wechsler-Reya R, Arrillaga-Romany I, Batchelor TT, Wen PY, Oster W, Allen JE. PMID: 30559168; PMCID: PMC7259201.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    34. Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors. Eur J Med Chem. 2019 Feb 01; 163:320-332. Teske KA, Dash RC, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 30529635; PMCID: PMC6358021.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    35. Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. Eur J Med Chem. 2019 Jan 15; 162:495-506. Maschinot CA, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 30471551.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    36. Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun. 2018 11 02; 9(1):4651. Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH. PMID: 30389946; PMCID: PMC6214967.
      View in: PubMed   Mentions:    Fields:    
    37. Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun. 2018 10 08; 9(1):4121. Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH. PMID: 30297829; PMCID: PMC6175869.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    38. Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma. Sci Signal. 2018 09 11; 11(547). Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, Theruvath J, Nitta R, Qi L, Li XN, Li G, Taylor MD, Wechsler-Reya RJ, Pinna LA, Cho YJ, Fuller MT, Elias JE, Scott MP. PMID: 30206138; PMCID: PMC6475502.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    39. Publisher Correction: N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci. 2018 Aug; 21(8):1139. Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC. PMID: 29880878.
      View in: PubMed   Mentions: 3     Fields:    
    40. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018 05 31; 173(6):1549. Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD. PMID: 29856958.
      View in: PubMed   Mentions: 15     Fields:    
    41. Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies. Annu Rev Neurosci. 2018 07 08; 41:207-232. Wang J, Garancher A, Ramaswamy V, Wechsler-Reya RJ. PMID: 29641939.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    42. NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma. Cancer Cell. 2018 03 12; 33(3):435-449.e6. Garancher A, Lin CY, Morabito M, Richer W, Rocques N, Larcher M, Bihannic L, Smith K, Miquel C, Leboucher S, Herath NI, Dupuy F, Varlet P, Haberler C, Walczak C, El Tayara N, Volk A, Puget S, Doz F, Delattre O, Druillennec S, Ayrault O, Wechsler-Reya RJ, Eychène A, Bourdeaut F, Northcott PA, Pouponnot C. PMID: 29533784; PMCID: PMC6368680.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
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    80. Spheres without influence: dissociating in vitro self-renewal from tumorigenic potential in glioma. Cancer Cell. 2012 Jan 17; 21(1):1-3. Read TA, Wechsler-Reya RJ. PMID: 22264781.
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    81. CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma. Cancer Res. 2012 Jan 01; 72(1):122-32. Sengupta R, Dubuc A, Ward S, Yang L, Northcott P, Woerner BM, Kroll K, Luo J, Taylor MD, Wechsler-Reya RJ, Rubin JB. PMID: 22052462; PMCID: PMC3520097.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    82. A malignant oligarchy: progenitors govern the behavior of oligodendrogliomas. Cancer Cell. 2010 Dec 14; 18(6):546-7. Pei Y, Wechsler-Reya RJ. PMID: 21156279; PMCID: PMC3012268.
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    83. Subtypes of medulloblastoma have distinct developmental origins. Nature. 2010 Dec 23; 468(7327):1095-9. Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ. PMID: 21150899; PMCID: PMC3059767.
      View in: PubMed   Mentions: 362     Fields:    Translation:HumansAnimals
    84. Defining future directions in spinal cord tumor research: proceedings from the National Institutes of Health workshop. J Neurosurg Spine. 2010 Feb; 12(2):117-21. Claus EB, Abdel-Wahab M, Burger PC, Engelhard HH, Ellison DW, Gaiano N, Gutmann DH, Heck DA, Holland EC, Jallo GI, Kruchko C, Kun LE, Maria BL, Rumboldt Z, Seminara D, Spinella GM, Stophel L, Wechsler-Reya R, Wrensch M, Gilbertson RJ. PMID: 20121344; PMCID: PMC3193276.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    85. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell. 2009 Feb 03; 15(2):135-47. Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, Febbo PG, Wechsler-Reya RJ. PMID: 19185848; PMCID: PMC2664097.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    86. N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. Genes Dev. 2009 Jan 15; 23(2):157-70. Kessler JD, Hasegawa H, Brun SN, Emmenegger BA, Yang ZJ, Dutton JW, Wang F, Wechsler-Reya RJ. PMID: 19171780; PMCID: PMC2648542.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    87. Stem cells and the origin and propagation of brain tumors. J Child Neurol. 2008 Oct; 23(10):1172-8. Emmenegger BA, Wechsler-Reya RJ. PMID: 18952583; PMCID: PMC3674560.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    88. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell. 2008 Aug 12; 14(2):135-45. Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ, Wechsler-Reya RJ. PMID: 18691548; PMCID: PMC2538687.
      View in: PubMed   Mentions: 329     Fields:    Translation:HumansAnimalsCells
    89. Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20820-5. Johnson CE, Huang YY, Parrish AB, Smith MI, Vaughn AE, Zhang Q, Wright KM, Van Dyke T, Wechsler-Reya RJ, Kornbluth S, Deshmukh M. PMID: 18093951; PMCID: PMC2409225.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    90. Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2973-8. Fogarty MP, Emmenegger BA, Grasfeder LL, Oliver TG, Wechsler-Reya RJ. PMID: 17299056; PMCID: PMC1815291.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    91. Hit 'em where they live: targeting the cancer stem cell niche. Cancer Cell. 2007 Jan; 11(1):3-5. Yang ZJ, Wechsler-Reya RJ. PMID: 17222787.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    92. Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol Cell Biol. 2006 Oct; 26(20):7550-60. Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG. PMID: 16908539; PMCID: PMC1636865.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    93. The neurobiology of neurooncology. Ann Neurol. 2006 Jul; 60(1):3-11. Read TA, Hegedus B, Wechsler-Reya R, Gutmann DH. PMID: 16802285.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    94. Morphing into cancer: the role of developmental signaling pathways in brain tumor formation. J Neurobiol. 2005 Sep 15; 64(4):458-75. Fogarty MP, Kessler JD, Wechsler-Reya RJ. PMID: 16041741.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    95. Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci. 2005 Jun; 8(6):723-9. Lee A, Kessler JD, Read TA, Kaiser C, Corbeil D, Huttner WB, Johnson JE, Wechsler-Reya RJ. PMID: 15908947; PMCID: PMC2377345.
      View in: PubMed   Mentions: 193     Fields:    Translation:AnimalsCells
    96. Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. Development. 2005 May; 132(10):2425-39. Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM, Wechsler-Reya RJ. PMID: 15843415.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    97. Getting at the root and stem of brain tumors. Neuron. 2004 Jun 24; 42(6):885-8. Oliver TG, Wechsler-Reya RJ. PMID: 15207233.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    98. Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7331-6. Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP, Wechsler-Reya RJ. PMID: 12777630; PMCID: PMC165875.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    99. Analysis of gene expression in the normal and malignant cerebellum. Recent Prog Horm Res. 2003; 58:227-48. Wechsler-Reya RJ. PMID: 12795421.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    100. Caught in the matrix: how vitronectin controls neuronal differentiation. Trends Neurosci. 2001 Dec; 24(12):680-2. Wechsler-Reya RJ. PMID: 11718852.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    101. The developmental biology of brain tumors. Annu Rev Neurosci. 2001; 24:385-428. Wechsler-Reya R, Scott MP. PMID: 11283316.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimals
    102. Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. Genes Chromosomes Cancer. 2000 May; 28(1):77-81. Zurawel RH, Allen C, Wechsler-Reya R, Scott MP, Raffel C. PMID: 10738305.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    103. Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity. Int J Cancer. 2000 Feb 01; 85(3):376-83. Ge K, Duhadaway J, Sakamuro D, Wechsler-Reya R, Reynolds C, Prendergast GC. PMID: 10652430.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    104. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron. 1999 Jan; 22(1):103-14. Wechsler-Reya RJ, Scott MP. PMID: 10027293.
      View in: PubMed   Mentions: 532     Fields:    Translation:AnimalsCells
    105. A role for the putative tumor suppressor Bin1 in muscle cell differentiation. Mol Cell Biol. 1998 Jan; 18(1):566-75. Wechsler-Reya RJ, Elliott KJ, Prendergast GC. PMID: 9418903; PMCID: PMC121524.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    106. Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. J Biol Chem. 1997 Dec 12; 272(50):31453-8. Wechsler-Reya R, Sakamuro D, Zhang J, Duhadaway J, Prendergast GC. PMID: 9395479.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    107. The putative tumor suppressor BIN1 is a short-lived nuclear phosphoprotein, the localization of which is altered in malignant cells. Cancer Res. 1997 Aug 01; 57(15):3258-63. Wechsler-Reya R, Elliott K, Herlyn M, Prendergast GC. PMID: 9242458.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    108. Retinal development: communication helps you see the light. Curr Biol. 1997 Jul 01; 7(7):R433-6. Wechsler-Reya RJ, Barres BA. PMID: 9210366.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    109. Lipopolysaccharide prevents apoptosis and induces responsiveness to antigen receptor cross-linking in immature B cells. Immunology. 1996 Nov; 89(3):356-62. Wechsler-Reya RJ, Monroe JG. PMID: 8958047; PMCID: PMC1456554.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    110. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet. 1996 Sep; 14(1):69-77. Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC. PMID: 8782822.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    111. Immature stage B cells enter but do not progress beyond the early G1 phase of the cell cycle in response to antigen receptor signaling. J Immunol. 1996 Jun 15; 156(12):4562-9. Carman JA, Wechsler-Reya RJ, Monroe JG. PMID: 8648097.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    112. Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors. Cancer Res. 1996 Jun 01; 56(11):2626-32. Prendergast GC, Davide JP, Lebowitz PF, Wechsler-Reya R, Kohl NE. PMID: 8653708.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    113. The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. Genomics. 1996 Apr 15; 33(2):329-31. Negorev D, Riethman H, Wechsler-Reya R, Sakamuro D, Prendergast GC, Simon D. PMID: 8725406.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
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