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Robert Wechsler-Reya

Title(s)Adjunct Professor, Pediatrics
SchoolHealth Sciences
Address9500 Gilman Drive #0831
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Identifying and Targeting the Drivers of Pediatric Brain Tumors
    NIH R35NS122339May 1, 2021 - Apr 30, 2029
    Role: Principal Investigator
    Optimization and Characterization of MYC Degraders for Pediatric Medulloblastoma
    NIH R61NS116191May 15, 2020 - Apr 30, 2022
    Role: Co-Principal Investigator
    Regulation of Medulloblastoma Metastasis by Emp1
    NIH R01NS096368Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Mouse models to discover new drivers of medulloblastoma
    NIH R01CA159859Apr 4, 2011 - Jan 31, 2022
    Role: Co-Principal Investigator
    Identification of a Mitogen for Neuronal Progenitors in the Embryonic Cerebellum
    NIH R03NS067362Sep 15, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Stem Cells, Progenitors, and the Origin of Medulloblastoma
    NIH R01CA122759Apr 1, 2009 - Jan 31, 2014
    Role: Principal Investigator
    Control of Medulloblastoma Migration &Survival by Unc5c
    NIH R01NS052323Jun 1, 2006 - May 31, 2011
    Role: Principal Investigator
    Control of Cerebellar Development by FGF signaling
    NIH R01MH067916Dec 17, 2003 - Nov 30, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neoplastic and immune single cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma. Neuro Oncol. 2021 Jun 02. Riemondy KA, Venkataraman S, Willard N, Nellan A, Sanford B, Griesinger AM, Amani V, Mitra S, Hankinson TC, Handler MH, Sill M, Ocasio J, Weir SJ, Malawsky DS, Gershon TR, Garancher A, Wechsler-Reya RJ, Hesselberth JR, Foreman NK, Donson AM, Vibhakar R. PMID: 34077540.
      View in: PubMed   Mentions:
    2. Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth. Commun Biol. 2021 May 11; 4(1):552. Qiu R, Wu J, Gudenas B, Northcott PA, Wechsler-Reya RJ, Lu Q. PMID: 33976373.
      View in: PubMed   Mentions:
    3. The long noncoding RNA lnc-HLX-2-7 is oncogenic in Group 3 medulloblastomas. Neuro Oncol. 2021 Apr 12; 23(4):572-585. Katsushima K, Lee B, Kunhiraman H, Zhong C, Murad R, Yin J, Liu B, Garancher A, Gonzalez-Gomez I, Monforte HL, Stapleton S, Vibhakar R, Bettegowda C, Wechsler-Reya RJ, Jallo G, Raabe E, Eberhart CG, Perera RJ. PMID: 33844835.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. A JAK/STAT-MEDIATED INFLAMMATORY SIGNALING CASCADE DRIVES ONCOGENESIS IN AF10-REARRANGED AML. Blood. 2021 Mar 09. Chen BR, Deshpande A, Barbosa KO, Kleppe M, Lei X, Yeddula N, Sánchez Vela P, Campos AR, Wechsler-Reya RJ, Bagchi A, Meshinchi S, Eaves CJ, Jeremias I, Haferlach T, Frank DA, Ronai ZA, Chanda S, Armstrong SA, Adams P, Levine RL, Deshpande A. PMID: 33690798.
      View in: PubMed   Mentions:    Fields:    
    5. Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab002. Chan TSY, Picard D, Hawkins CE, Lu M, Pfister S, Korshunov A, Roussel MF, Wechsler-Reya RJ, Henkin J, Bouffet E, Huang A. PMID: 33629064.
      View in: PubMed   Mentions:
    6. Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma. Sci Transl Med. 2021 Jan 20; 13(577). Endersby R, Whitehouse J, Pribnow A, Kuchibhotla M, Hii H, Carline B, Gande S, Stripay J, Ancliffe M, Howlett M, Schoep T, George C, Andradas C, Dyer P, Schluck M, Patterson B, Tacheva-Gigorova SK, Cooper MN, Robinson G, Stewart C, Pfister SM, Kool M, Milde T, Gajjar A, Johns T, Wechsler-Reya RJ, Roussel MF, Gottardo NG. PMID: 33472956.
      View in: PubMed   Mentions: 1     Fields:    
    7. Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor. Mol Ther Oncolytics. 2021 Mar 26; 20:265-276. Dash RC, Wen J, Zaino AM, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 33614910.
      View in: PubMed   Mentions:
    8. Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma. Cancer Res. 2020 Dec 01; 80(23):5393-5407. Rusert JM, Juarez EF, Brabetz S, Jensen J, Garancher A, Chau LQ, Tacheva-Grigorova SK, Wahab S, Udaka YT, Finlay D, Seker-Cin H, Reardon B, Gröbner S, Serrano J, Ecker J, Qi L, Kogiso M, Du Y, Baxter PA, Henderson JJ, Berens ME, Vuori K, Milde T, Cho YJ, Li XN, Olson JM, Reyes I, Snuderl M, Wong TC, Dimmock DP, Nahas SA, Malicki D, Crawford JR, Levy ML, Van Allen EM, Pfister SM, Tamayo P, Kool M, Mesirov JP, Wechsler-Reya RJ. PMID: 33046443.
      View in: PubMed   Mentions:    Fields:    
    9. Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma. Neuro Oncol. 2020 Aug 21. Ecker J, Thatikonda V, Sigismondo G, Selt F, Valinciute G, Oehme I, Müller C, Buhl JL, Ridinger J, Usta D, Qin N, van Tilburg CM, Herold-Mende C, Remke M, Sahm F, Westermann F, Kool M, Wechsler-Reya RJ, Chavez L, Krijgsveld J, Jäger N, Pfister SM, Witt O, Milde T. PMID: 32822486.
      View in: PubMed   Mentions:    Fields:    
    10. NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma. Cell Rep. 2020 06 23; 31(12):107782. Cheng Y, Liao S, Xu G, Hu J, Guo D, Du F, Contreras A, Cai KQ, Peri S, Wang Y, Corney DC, Noronha AM, Chau LQ, Zhou G, Wiest DL, Bellacosa A, Wechsler-Reya RJ, Zhao Y, Yang ZJ. PMID: 32579914.
      View in: PubMed   Mentions: 1     Fields:    
    11. Characterization of G-CSF receptor expression in medulloblastoma. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa062. Paul MR, Huo Y, Liu A, Lesperance J, Garancher A, Wechsler-Reya RJ, Zage PE. PMID: 32642714.
      View in: PubMed   Mentions:
    12. Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma. Nat Neurosci. 2020 07; 23(7):842-853. Garancher A, Suzuki H, Haricharan S, Chau LQ, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, Cavalli FMG, Farooq H, Ramaswamy V, Jones SJM, Moore RA, Mungall AJ, Ma Y, Thiessen N, Li Y, Morcavallo A, Qi L, Kogiso M, Du Y, Baxter P, Henderson JJ, Crawford JR, Levy ML, Olson JM, Cho YJ, Deshpande AJ, Li XN, Chesler L, Marra MA, Wajant H, Becher OJ, Bradley LM, Ware CF, Taylor MD, Wechsler-Reya RJ. PMID: 32424282.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin avß5 Axis. Cell Stem Cell. 2020 02 06; 26(2):187-204.e10. Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038.
      View in: PubMed   Mentions: 9     Fields:    
    14. Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy. Cell Stem Cell. 2019 Dec 05; 25(6):855-870.e11. Cancer M, Hutter S, Holmberg KO, Rosén G, Sundström A, Tailor J, Bergström T, Garancher A, Essand M, Wechsler-Reya RJ, Falk A, Weishaupt H, Swartling FJ. PMID: 31786016.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. Biallelic loss of GNAS in a patient with pediatric medulloblastoma. Cold Spring Harb Mol Case Stud. 2019 10; 5(5). Tokita MJ, Nahas S, Briggs B, Malicki DM, Mesirov JP, Reyes IAC, Farnaes L, Levy ML, Kingsmore SF, Dimmock D, Crawford JR, Wechsler-Reya RJ. PMID: 31624069.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature. 2019 10; 574(7780):707-711. Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Jouvet A, Fèvre-Montange M, Garrè ML, Nageswara Rao AA, Giannini C, Kros JM, French PJ, Jabado N, Ng HK, Poon WS, Eberhart CG, Pollack IF, Olson JM, Weiss WA, Kumabe T, López-Aguilar E, Lach B, Massimino M, Van Meir EG, Rubin JB, Vibhakar R, Chambless LB, Kijima N, Klekner A, Bognár L, Chan JA, Faria CC, Ragoussis J, Pfister SM, Goldenberg A, Wechsler-Reya RJ, Bailey SD, Garzia L, Morrissy AS, Marra MA, Huang X, Malkin D, Ayrault O, Ramaswamy V, Puente XS, Calarco JA, Stein L, Taylor MD. PMID: 31664194.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    17. Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. PLoS One. 2019; 14(9):e0214901. Chahal KK, Li J, Kufareva I, Parle M, Durden DL, Wechsler-Reya RJ, Chen CC, Abagyan R. PMID: 31539380.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice. Sci Rep. 2019 08 29; 9(1):12587. Householder KT, Dharmaraj S, Sandberg DI, Wechsler-Reya RJ, Sirianni RW. PMID: 31467368.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    19. Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. 2019 08; 572(7767):74-79. Hovestadt V, Smith KS, Bihannic L, Filbin MG, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, Phoenix TN, Hadley JL, Tong Y, Houston J, Ashmun RA, DeCuypere M, Sharma T, Flasch D, Silkov A, Ligon KL, Pomeroy SL, Rivera MN, Rozenblatt-Rosen O, Rusert JM, Wechsler-Reya RJ, Li XN, Peyrl A, Gojo J, Kirchhofer D, Lötsch D, Czech T, Dorfer C, Haberler C, Geyeregger R, Halfmann A, Gawad C, Easton J, Pfister SM, Regev A, Gajjar A, Orr BA, Slavc I, Robinson GW, Bernstein BE, Suvà ML, Northcott PA. PMID: 31341285.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    20. Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors. J Med Chem. 2019 04 25; 62(8):3873-3885. Pace JR, Teske KA, Chau LQ, Dash RC, Zaino AM, Wechsler-Reya RJ, Hadden MK. PMID: 30896941.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    21. Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma. Cancer Res. 2019 05 01; 79(9):2208-2219. Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, Malkin D, Ellison DW, VandenBerg SR, Eberhart CG, Sears RC, Roussel MF, Gilbertson RJ, Wechsler-Reya RJ. PMID: 30885981.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    22. Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors. Cancer Res. 2019 03 01; 79(5):905-917. Beckmann PJ, Larson JD, Larsson AT, Ostergaard JP, Wagner S, Rahrmann EP, Shamsan GA, Otto GM, Williams RL, Wang J, Lee C, Tschida BR, Das P, Dubuc AM, Moriarity BS, Picard D, Wu X, Rodriguez FJ, Rosemarie Q, Krebs RD, Molan AM, Demer AM, Frees MM, Rizzardi AE, Schmechel SC, Eberhart CG, Jenkins RB, Wechsler-Reya RJ, Odde DJ, Huang A, Taylor MD, Sarver AL, Largaespada DA. PMID: 30674530.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    23. Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Nat Commun. 2019 01 18; 10(1):332. Lee C, Rudneva VA, Erkek S, Zapatka M, Chau LQ, Tacheva-Grigorova SK, Garancher A, Rusert JM, Aksoy O, Lea R, Mohammad HP, Wang J, Weiss WA, Grimes HL, Pfister SM, Northcott PA, Wechsler-Reya RJ. PMID: 30659187.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism. Clin Cancer Res. 2019 04 01; 25(7):2305-2313. Prabhu VV, Madhukar NS, Gilvary C, Kline CLB, Oster S, El-Deiry WS, Elemento O, Doherty F, VanEngelenburg A, Durrant J, Tarapore RS, Deacon S, Charter N, Jung J, Park DM, Gilbert MR, Rusert J, Wechsler-Reya R, Arrillaga-Romany I, Batchelor TT, Wen PY, Oster W, Allen JE. PMID: 30559168.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    25. Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors. Eur J Med Chem. 2019 Feb 01; 163:320-332. Teske KA, Dash RC, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 30529635.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    26. Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. Eur J Med Chem. 2019 Jan 15; 162:495-506. Maschinot CA, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 30471551.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    27. Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun. 2018 11 02; 9(1):4651. Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH. PMID: 30389946.
      View in: PubMed   Mentions:    Fields:    
    28. Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun. 2018 10 08; 9(1):4121. Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH. PMID: 30297829.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    29. Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma. Sci Signal. 2018 09 11; 11(547). Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, Theruvath J, Nitta R, Qi L, Li XN, Li G, Taylor MD, Wechsler-Reya RJ, Pinna LA, Cho YJ, Fuller MT, Elias JE, Scott MP. PMID: 30206138.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    30. Publisher Correction: N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci. 2018 Aug; 21(8):1139. Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC. PMID: 29880878.
      View in: PubMed   Mentions: 1     Fields:    
    31. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018 05 31; 173(6):1549. Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD. PMID: 29856958.
      View in: PubMed   Mentions: 7     Fields:    
    32. Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies. Annu Rev Neurosci. 2018 07 08; 41:207-232. Wang J, Garancher A, Ramaswamy V, Wechsler-Reya RJ. PMID: 29641939.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    33. NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma. Cancer Cell. 2018 03 12; 33(3):435-449.e6. Garancher A, Lin CY, Morabito M, Richer W, Rocques N, Larcher M, Bihannic L, Smith K, Miquel C, Leboucher S, Herath NI, Dupuy F, Varlet P, Haberler C, Walczak C, El Tayara N, Volk A, Puget S, Doz F, Delattre O, Druillennec S, Ayrault O, Wechsler-Reya RJ, Eychène A, Bourdeaut F, Northcott PA, Pouponnot C. PMID: 29533784.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    34. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018 02 22; 172(5):1050-1062.e14. Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD. PMID: 29474906.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    35. N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci. 2018 02; 21(2):195-206. Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya RJ, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao JC. PMID: 29335608.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    36. PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. Cancer Res. 2017 11 01; 77(21):e62-e66. Meehan TF, Conte N, Goldstein T, Inghirami G, Murakami MA, Brabetz S, Gu Z, Wiser JA, Dunn P, Begley DA, Krupke DM, Bertotti A, Bruna A, Brush MH, Byrne AT, Caldas C, Christie AL, Clark DA, Dowst H, Dry JR, Doroshow JH, Duchamp O, Evrard YA, Ferretti S, Frese KK, Goodwin NC, Greenawalt D, Haendel MA, Hermans E, Houghton PJ, Jonkers J, Kemper K, Khor TO, Lewis MT, Lloyd KCK, Mason J, Medico E, Neuhauser SB, Olson JM, Peeper DS, Rueda OM, Seong JK, Trusolino L, Vinolo E, Wechsler-Reya RJ, Weinstock DM, Welm A, Weroha SJ, Amant F, Pfister SM, Kool M, Parkinson H, Butte AJ, Bult CJ. PMID: 29092942.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    37. Brain Tumor Stem Cells Remain in Play. J Clin Oncol. 2017 07 20; 35(21):2428-2431. Parada LF, Dirks PB, Wechsler-Reya RJ. PMID: 28640710.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    38. Molecular mechanisms and therapeutic targets in pediatric brain tumors. Sci Signal. 2017 Mar 14; 10(470). Liu KW, Pajtler KW, Worst BC, Pfister SM, Wechsler-Reya RJ. PMID: 28292958.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    39. Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo. J Control Release. 2017 05 10; 253:172-182. Medina DX, Householder KT, Ceton R, Kovalik T, Heffernan JM, Shankar RV, Bowser RP, Wechsler-Reya RJ, Sirianni RW. PMID: 28263836.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    40. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. PMID: 28178237.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    41. MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. Cancer Cell. 2017 02 13; 31(2):270-285. Mollaoglu G, Guthrie MR, Böhm S, Brägelmann J, Can I, Ballieu PM, Marx A, George J, Heinen C, Chalishazar MD, Cheng H, Ireland AS, Denning KE, Mukhopadhyay A, Vahrenkamp JM, Berrett KC, Mosbruger TL, Wang J, Kohan JL, Salama ME, Witt BL, Peifer M, Thomas RK, Gertz J, Johnson JE, Gazdar AF, Wechsler-Reya RJ, Sos ML, Oliver TG. PMID: 28089889.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimals
    42. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic. J Med Chem. 2016 04 28; 59(8):3635-49. Pace JR, DeBerardinis AM, Sail V, Tacheva-Grigorova SK, Chan KA, Tran R, Raccuia DS, Wechsler-Reya RJ, Hadden MK. PMID: 27014922.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    43. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nat Cell Biol. 2016 Apr; 18(4):418-30. Li L, Grausam KB, Wang J, Lun MP, Ohli J, Lidov HG, Calicchio ML, Zeng E, Salisbury JL, Wechsler-Reya RJ, Lehtinen MK, Schüller U, Zhao H. PMID: 26999738.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    44. HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma. Cancer Cell. 2016 Mar 14; 29(3):311-323. Pei Y, Liu KW, Wang J, Garancher A, Tao R, Esparza LA, Maier DL, Udaka YT, Murad N, Morrissy S, Seker-Cin H, Brabetz S, Qi L, Kogiso M, Schubert S, Olson JM, Cho YJ, Li XN, Crawford JR, Levy ML, Kool M, Pfister SM, Taylor MD, Wechsler-Reya RJ. PMID: 26977882.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
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    92. The developmental biology of brain tumors. Annu Rev Neurosci. 2001; 24:385-428. Wechsler-Reya R, Scott MP. PMID: 11283316.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimals
    93. Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. Genes Chromosomes Cancer. 2000 May; 28(1):77-81. Zurawel RH, Allen C, Wechsler-Reya R, Scott MP, Raffel C. PMID: 10738305.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    94. Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity. Int J Cancer. 2000 Feb 01; 85(3):376-83. Ge K, Duhadaway J, Sakamuro D, Wechsler-Reya R, Reynolds C, Prendergast GC. PMID: 10652430.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    95. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron. 1999 Jan; 22(1):103-14. Wechsler-Reya RJ, Scott MP. PMID: 10027293.
      View in: PubMed   Mentions: 451     Fields:    Translation:AnimalsCells
    96. A role for the putative tumor suppressor Bin1 in muscle cell differentiation. Mol Cell Biol. 1998 Jan; 18(1):566-75. Wechsler-Reya RJ, Elliott KJ, Prendergast GC. PMID: 9418903.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    97. Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. J Biol Chem. 1997 Dec 12; 272(50):31453-8. Wechsler-Reya R, Sakamuro D, Zhang J, Duhadaway J, Prendergast GC. PMID: 9395479.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    98. The putative tumor suppressor BIN1 is a short-lived nuclear phosphoprotein, the localization of which is altered in malignant cells. Cancer Res. 1997 Aug 01; 57(15):3258-63. Wechsler-Reya R, Elliott K, Herlyn M, Prendergast GC. PMID: 9242458.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    99. Retinal development: communication helps you see the light. Curr Biol. 1997 Jul 01; 7(7):R433-6. Wechsler-Reya RJ, Barres BA. PMID: 9210366.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    100. Lipopolysaccharide prevents apoptosis and induces responsiveness to antigen receptor cross-linking in immature B cells. Immunology. 1996 Nov; 89(3):356-62. Wechsler-Reya RJ, Monroe JG. PMID: 8958047.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    101. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet. 1996 Sep; 14(1):69-77. Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC. PMID: 8782822.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    102. Immature stage B cells enter but do not progress beyond the early G1 phase of the cell cycle in response to antigen receptor signaling. J Immunol. 1996 Jun 15; 156(12):4562-9. Carman JA, Wechsler-Reya RJ, Monroe JG. PMID: 8648097.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    103. Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors. Cancer Res. 1996 Jun 01; 56(11):2626-32. Prendergast GC, Davide JP, Lebowitz PF, Wechsler-Reya R, Kohl NE. PMID: 8653708.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    104. The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. Genomics. 1996 Apr 15; 33(2):329-31. Negorev D, Riethman H, Wechsler-Reya R, Sakamuro D, Prendergast GC, Simon D. PMID: 8725406.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
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