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Robert Wechsler-Reya

Title(s)Adjunct Professor, Pediatrics
SchoolHealth Sciences
Address9500 Gilman Drive #0831
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Optimization and Characterization of MYC Degraders for Pediatric Medulloblastoma
    NIH R61NS116191May 15, 2020 - Apr 30, 2022
    Role: Co-Principal Investigator
    Mouse models to discover new drivers of medulloblastoma
    NIH R01CA159859Feb 1, 2017 - Mar 31, 2016
    Role: Co-Principal Investigator
    Regulation of Medulloblastoma Metastasis by Emp1
    NIH R01NS096368Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Identification of a Mitogen for Neuronal Progenitors in the Embryonic Cerebellum
    NIH R03NS067362Sep 15, 2009 - Oct 31, 2010
    Role: Principal Investigator
    Stem Cells, Progenitors, and the Origin of Medulloblastoma
    NIH R01CA122759Apr 1, 2009 - Nov 30, 2010
    Role: Principal Investigator
    Control of Medulloblastoma Migration &Survival by Unc5c
    NIH R01NS052323Jun 1, 2006 - Nov 30, 2010
    Role: Principal Investigator
    Control of Cerebellar Development by FGF signaling
    NIH R01MH067916Dec 17, 2003 - Nov 30, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab002. Chan TSY, Picard D, Hawkins CE, Lu M, Pfister S, Korshunov A, Roussel MF, Wechsler-Reya RJ, Henkin J, Bouffet E, Huang A. PMID: 33629064.
      View in: PubMed   Mentions:
    2. Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma. Sci Transl Med. 2021 Jan 20; 13(577). Endersby R, Whitehouse J, Pribnow A, Kuchibhotla M, Hii H, Carline B, Gande S, Stripay J, Ancliffe M, Howlett M, Schoep T, George C, Andradas C, Dyer P, Schluck M, Patterson B, Tacheva-Gigorova SK, Cooper MN, Robinson G, Stewart C, Pfister SM, Kool M, Milde T, Gajjar A, Johns T, Wechsler-Reya RJ, Roussel MF, Gottardo NG. PMID: 33472956.
      View in: PubMed   Mentions: 1     Fields:    
    3. Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor. Mol Ther Oncolytics. 2021 Mar 26; 20:265-276. Dash RC, Wen J, Zaino AM, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 33614910.
      View in: PubMed   Mentions:
    4. Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma. Cancer Res. 2020 Dec 01; 80(23):5393-5407. Rusert JM, Juarez EF, Brabetz S, Jensen J, Garancher A, Chau LQ, Tacheva-Grigorova SK, Wahab S, Udaka YT, Finlay D, Seker-Cin H, Reardon B, Gröbner S, Serrano J, Ecker J, Qi L, Kogiso M, Du Y, Baxter PA, Henderson JJ, Berens ME, Vuori K, Milde T, Cho YJ, Li XN, Olson JM, Reyes I, Snuderl M, Wong TC, Dimmock DP, Nahas SA, Malicki D, Crawford JR, Levy ML, Van Allen EM, Pfister SM, Tamayo P, Kool M, Mesirov JP, Wechsler-Reya RJ. PMID: 33046443.
      View in: PubMed   Mentions:    Fields:    
    5. Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma. Neuro Oncol. 2020 Aug 21. Ecker J, Thatikonda V, Sigismondo G, Selt F, Valinciute G, Oehme I, Müller C, Buhl JL, Ridinger J, Usta D, Qin N, van Tilburg CM, Herold-Mende C, Remke M, Sahm F, Westermann F, Kool M, Wechsler-Reya RJ, Chavez L, Krijgsveld J, Jäger N, Pfister SM, Witt O, Milde T. PMID: 32822486.
      View in: PubMed   Mentions:    Fields:    
    6. NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma. Cell Rep. 2020 06 23; 31(12):107782. Cheng Y, Liao S, Xu G, Hu J, Guo D, Du F, Contreras A, Cai KQ, Peri S, Wang Y, Corney DC, Noronha AM, Chau LQ, Zhou G, Wiest DL, Bellacosa A, Wechsler-Reya RJ, Zhao Y, Yang ZJ. PMID: 32579914.
      View in: PubMed   Mentions: 1     Fields:    
    7. Characterization of G-CSF receptor expression in medulloblastoma. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa062. Paul MR, Huo Y, Liu A, Lesperance J, Garancher A, Wechsler-Reya RJ, Zage PE. PMID: 32642714.
      View in: PubMed   Mentions:
    8. Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma. Nat Neurosci. 2020 07; 23(7):842-853. Garancher A, Suzuki H, Haricharan S, Chau LQ, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, Cavalli FMG, Farooq H, Ramaswamy V, Jones SJM, Moore RA, Mungall AJ, Ma Y, Thiessen N, Li Y, Morcavallo A, Qi L, Kogiso M, Du Y, Baxter P, Henderson JJ, Crawford JR, Levy ML, Olson JM, Cho YJ, Deshpande AJ, Li XN, Chesler L, Marra MA, Wajant H, Becher OJ, Bradley LM, Ware CF, Taylor MD, Wechsler-Reya RJ. PMID: 32424282.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    9. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin avß5 Axis. Cell Stem Cell. 2020 02 06; 26(2):187-204.e10. Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038.
      View in: PubMed   Mentions: 9     Fields:    
    10. Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy. Cell Stem Cell. 2019 Dec 05; 25(6):855-870.e11. Cancer M, Hutter S, Holmberg KO, Rosén G, Sundström A, Tailor J, Bergström T, Garancher A, Essand M, Wechsler-Reya RJ, Falk A, Weishaupt H, Swartling FJ. PMID: 31786016.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Biallelic loss of GNAS in a patient with pediatric medulloblastoma. Cold Spring Harb Mol Case Stud. 2019 10; 5(5). Tokita MJ, Nahas S, Briggs B, Malicki DM, Mesirov JP, Reyes IAC, Farnaes L, Levy ML, Kingsmore SF, Dimmock D, Crawford JR, Wechsler-Reya RJ. PMID: 31624069.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature. 2019 10; 574(7780):707-711. Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Jouvet A, Fèvre-Montange M, Garrè ML, Nageswara Rao AA, Giannini C, Kros JM, French PJ, Jabado N, Ng HK, Poon WS, Eberhart CG, Pollack IF, Olson JM, Weiss WA, Kumabe T, López-Aguilar E, Lach B, Massimino M, Van Meir EG, Rubin JB, Vibhakar R, Chambless LB, Kijima N, Klekner A, Bognár L, Chan JA, Faria CC, Ragoussis J, Pfister SM, Goldenberg A, Wechsler-Reya RJ, Bailey SD, Garzia L, Morrissy AS, Marra MA, Huang X, Malkin D, Ayrault O, Ramaswamy V, Puente XS, Calarco JA, Stein L, Taylor MD. PMID: 31664194.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    13. Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. PLoS One. 2019; 14(9):e0214901. Chahal KK, Li J, Kufareva I, Parle M, Durden DL, Wechsler-Reya RJ, Chen CC, Abagyan R. PMID: 31539380.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice. Sci Rep. 2019 08 29; 9(1):12587. Householder KT, Dharmaraj S, Sandberg DI, Wechsler-Reya RJ, Sirianni RW. PMID: 31467368.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    15. Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. 2019 08; 572(7767):74-79. Hovestadt V, Smith KS, Bihannic L, Filbin MG, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, Phoenix TN, Hadley JL, Tong Y, Houston J, Ashmun RA, DeCuypere M, Sharma T, Flasch D, Silkov A, Ligon KL, Pomeroy SL, Rivera MN, Rozenblatt-Rosen O, Rusert JM, Wechsler-Reya RJ, Li XN, Peyrl A, Gojo J, Kirchhofer D, Lötsch D, Czech T, Dorfer C, Haberler C, Geyeregger R, Halfmann A, Gawad C, Easton J, Pfister SM, Regev A, Gajjar A, Orr BA, Slavc I, Robinson GW, Bernstein BE, Suvà ML, Northcott PA. PMID: 31341285.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    16. Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors. J Med Chem. 2019 04 25; 62(8):3873-3885. Pace JR, Teske KA, Chau LQ, Dash RC, Zaino AM, Wechsler-Reya RJ, Hadden MK. PMID: 30896941.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma. Cancer Res. 2019 05 01; 79(9):2208-2219. Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, Malkin D, Ellison DW, VandenBerg SR, Eberhart CG, Sears RC, Roussel MF, Gilbertson RJ, Wechsler-Reya RJ. PMID: 30885981.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors. Cancer Res. 2019 03 01; 79(5):905-917. Beckmann PJ, Larson JD, Larsson AT, Ostergaard JP, Wagner S, Rahrmann EP, Shamsan GA, Otto GM, Williams RL, Wang J, Lee C, Tschida BR, Das P, Dubuc AM, Moriarity BS, Picard D, Wu X, Rodriguez FJ, Rosemarie Q, Krebs RD, Molan AM, Demer AM, Frees MM, Rizzardi AE, Schmechel SC, Eberhart CG, Jenkins RB, Wechsler-Reya RJ, Odde DJ, Huang A, Taylor MD, Sarver AL, Largaespada DA. PMID: 30674530.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    19. Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Nat Commun. 2019 01 18; 10(1):332. Lee C, Rudneva VA, Erkek S, Zapatka M, Chau LQ, Tacheva-Grigorova SK, Garancher A, Rusert JM, Aksoy O, Lea R, Mohammad HP, Wang J, Weiss WA, Grimes HL, Pfister SM, Northcott PA, Wechsler-Reya RJ. PMID: 30659187.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism. Clin Cancer Res. 2019 04 01; 25(7):2305-2313. Prabhu VV, Madhukar NS, Gilvary C, Kline CLB, Oster S, El-Deiry WS, Elemento O, Doherty F, VanEngelenburg A, Durrant J, Tarapore RS, Deacon S, Charter N, Jung J, Park DM, Gilbert MR, Rusert J, Wechsler-Reya R, Arrillaga-Romany I, Batchelor TT, Wen PY, Oster W, Allen JE. PMID: 30559168.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    21. Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors. Eur J Med Chem. 2019 Feb 01; 163:320-332. Teske KA, Dash RC, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 30529635.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    22. Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling. Eur J Med Chem. 2019 Jan 15; 162:495-506. Maschinot CA, Chau LQ, Wechsler-Reya RJ, Hadden MK. PMID: 30471551.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    23. Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun. 2018 11 02; 9(1):4651. Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH. PMID: 30389946.
      View in: PubMed   Mentions:    Fields:    
    24. Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nat Commun. 2018 10 08; 9(1):4121. Kahn SA, Wang X, Nitta RT, Gholamin S, Theruvath J, Hutter G, Azad TD, Wadi L, Bolin S, Ramaswamy V, Esparza R, Liu KW, Edwards M, Swartling FJ, Sahoo D, Li G, Wechsler-Reya RJ, Reimand J, Cho YJ, Taylor MD, Weissman IL, Mitra SS, Cheshier SH. PMID: 30297829.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    25. Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma. Sci Signal. 2018 09 11; 11(547). Purzner T, Purzner J, Buckstaff T, Cozza G, Gholamin S, Rusert JM, Hartl TA, Sanders J, Conley N, Ge X, Langan M, Ramaswamy V, Ellis L, Litzenburger U, Bolin S, Theruvath J, Nitta R, Qi L, Li XN, Li G, Taylor MD, Wechsler-Reya RJ, Pinna LA, Cho YJ, Fuller MT, Elias JE, Scott MP. PMID: 30206138.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    26. Publisher Correction: N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci. 2018 Aug; 21(8):1139. PMID: 29880878.
      View in: PubMed   Mentions: 1     Fields:    
    27. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018 05 31; 173(6):1549. Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD. PMID: 29856958.
      View in: PubMed   Mentions: 7     Fields:    
    28. Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies. Annu Rev Neurosci. 2018 07 08; 41:207-232. PMID: 29641939.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    29. NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma. Cancer Cell. 2018 03 12; 33(3):435-449.e6. PMID: 29533784.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018 02 22; 172(5):1050-1062.e14. Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD. PMID: 29474906.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    31. N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci. 2018 02; 21(2):195-206. PMID: 29335608.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    32. PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. Cancer Res. 2017 11 01; 77(21):e62-e66. PMID: 29092942.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    33. Brain Tumor Stem Cells Remain in Play. J Clin Oncol. 2017 07 20; 35(21):2428-2431. PMID: 28640710.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    34. Molecular mechanisms and therapeutic targets in pediatric brain tumors. Sci Signal. 2017 Mar 14; 10(470). PMID: 28292958.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    35. Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo. J Control Release. 2017 05 10; 253:172-182. PMID: 28263836.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    36. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature. 2017 03 02; 543(7643):122-125. PMID: 28178237.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    37. MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. Cancer Cell. 2017 02 13; 31(2):270-285. PMID: 28089889.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimals
    38. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic. J Med Chem. 2016 04 28; 59(8):3635-49. PMID: 27014922.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    39. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nat Cell Biol. 2016 Apr; 18(4):418-30. PMID: 26999738.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    40. HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma. Cancer Cell. 2016 Mar 14; 29(3):311-323. PMID: 26977882.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    41. Divergent clonal selection dominates medulloblastoma at recurrence. Nature. 2016 Jan 21; 529(7586):351-7. PMID: 26760213.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    42. Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer. Cancer Res. 2015 Dec 15; 75(24):5176-5186. PMID: 26627009.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    43. Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma. Clin Cancer Res. 2016 Feb 01; 22(3):582-95. PMID: 26405194.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    44. Proteomic profiling of high risk medulloblastoma reveals functional biology. Oncotarget. 2015 Jun 10; 6(16):14584-95. PMID: 25970789.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    45. Cancer. For pediatric glioma, leave no histone unturned. Science. 2014 Dec 19; 346(6216):1458-9. PMID: 25525232.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    46. Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development. PLoS One. 2014; 9(12):e114433. PMID: 25493560.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    47. SnapShot: Medulloblastoma. Cancer Cell. 2014 Dec 08; 26(6):940-940.e1. PMID: 25490452.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    48. Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. Oncogene. 2015 Jul; 34(29):3770-9. PMID: 25241898.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    49. The G protein a subunit Gas is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nat Med. 2014 Sep; 20(9):1035-42. PMID: 25150496.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    50. Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat Med. 2014 Jul; 20(7):732-40. PMID: 24973920.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    51. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature. 2014 Jul 24; 511(7510):428-34. PMID: 25043047.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    52. Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature. 2014 Jun 26; 510(7506):537-41. PMID: 24847876.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    53. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell. 2014 Mar 17; 25(3):393-405. PMID: 24651015.
      View in: PubMed   Mentions: 205     Fields:    Translation:HumansAnimalsCells
    54. Cytogenetic prognostication within medulloblastoma subgroups. J Clin Oncol. 2014 Mar 20; 32(9):886-96. PMID: 24493713.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    55. Independently specified Atoh1 domains define novel developmental compartments in rhombomere 1. Development. 2014 Jan; 141(2):389-98. PMID: 24381197.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    56. BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer Res. 2014 Feb 15; 20(4):912-25. PMID: 24297863.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    57. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. Acta Neuropathol. 2013 Dec; 126(6):917-29. PMID: 24174164.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    58. A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity. Nat Neurosci. 2013 Dec; 16(12):1737-44. PMID: 24141309.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    59. Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases. Cancer Res. 2013 Oct 15; 73(20):6310-22. PMID: 24067506.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    60. The role of stem cells and progenitors in the genesis of medulloblastoma. Exp Neurol. 2014 Oct; 260:69-73. PMID: 23178582.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    61. Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma. Oncogene. 2013 Aug 29; 32(35):4181-8. PMID: 23045271.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    62. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 2012 Aug 02; 488(7409):49-56. PMID: 22832581.
      View in: PubMed   Mentions: 293     Fields:    Translation:HumansCells
    63. Review: personalized mice: modelling the molecular heterogeneity of medulloblastoma. Neuropathol Appl Neurobiol. 2012 Jun; 38(3):228-40. PMID: 22070547.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    64. Matching mice to malignancy: molecular subgroups and models of medulloblastoma. Childs Nerv Syst. 2012 Apr; 28(4):521-32. PMID: 22315164.
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    65. WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development. 2012 May; 139(10):1724-33. PMID: 22461560.
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    66. An animal model of MYC-driven medulloblastoma. Cancer Cell. 2012 Feb 14; 21(2):155-67. PMID: 22340590.
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    67. Spheres without influence: dissociating in vitro self-renewal from tumorigenic potential in glioma. Cancer Cell. 2012 Jan 17; 21(1):1-3. PMID: 22264781.
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    68. CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma. Cancer Res. 2012 Jan 01; 72(1):122-32. PMID: 22052462.
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    69. A malignant oligarchy: progenitors govern the behavior of oligodendrogliomas. Cancer Cell. 2010 Dec 14; 18(6):546-7. Pei Y, Wechsler-Reya RJ. PMID: 21156279.
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    70. Subtypes of medulloblastoma have distinct developmental origins. Nature. 2010 Dec 23; 468(7327):1095-9. Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ. PMID: 21150899.
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    71. Defining future directions in spinal cord tumor research: proceedings from the National Institutes of Health workshop. J Neurosurg Spine. 2010 Feb; 12(2):117-21. Claus EB, Abdel-Wahab M, Burger PC, Engelhard HH, Ellison DW, Gaiano N, Gutmann DH, Heck DA, Holland EC, Jallo GI, Kruchko C, Kun LE, Maria BL, Rumboldt Z, Seminara D, Spinella GM, Stophel L, Wechsler-Reya R, Wrensch M, Gilbertson RJ. PMID: 20121344.
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    72. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell. 2009 Feb 03; 15(2):135-47. Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, Febbo PG, Wechsler-Reya RJ. PMID: 19185848.
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    73. N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. Genes Dev. 2009 Jan 15; 23(2):157-70. Kessler JD, Hasegawa H, Brun SN, Emmenegger BA, Yang ZJ, Dutton JW, Wang F, Wechsler-Reya RJ. PMID: 19171780.
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    74. Stem cells and the origin and propagation of brain tumors. J Child Neurol. 2008 Oct; 23(10):1172-8. Emmenegger BA, Wechsler-Reya RJ. PMID: 18952583.
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    75. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell. 2008 Aug 12; 14(2):135-45. Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ, Wechsler-Reya RJ. PMID: 18691548.
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    76. Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20820-5. Johnson CE, Huang YY, Parrish AB, Smith MI, Vaughn AE, Zhang Q, Wright KM, Van Dyke T, Wechsler-Reya RJ, Kornbluth S, Deshmukh M. PMID: 18093951.
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    77. Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2973-8. Fogarty MP, Emmenegger BA, Grasfeder LL, Oliver TG, Wechsler-Reya RJ. PMID: 17299056.
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    78. Hit 'em where they live: targeting the cancer stem cell niche. Cancer Cell. 2007 Jan; 11(1):3-5. Yang ZJ, Wechsler-Reya RJ. PMID: 17222787.
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    79. Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol Cell Biol. 2006 Oct; 26(20):7550-60. Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG. PMID: 16908539.
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    80. The neurobiology of neurooncology. Ann Neurol. 2006 Jul; 60(1):3-11. Read TA, Hegedus B, Wechsler-Reya R, Gutmann DH. PMID: 16802285.
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    81. Morphing into cancer: the role of developmental signaling pathways in brain tumor formation. J Neurobiol. 2005 Sep 15; 64(4):458-75. Fogarty MP, Kessler JD, Wechsler-Reya RJ. PMID: 16041741.
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    82. Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci. 2005 Jun; 8(6):723-9. Lee A, Kessler JD, Read TA, Kaiser C, Corbeil D, Huttner WB, Johnson JE, Wechsler-Reya RJ. PMID: 15908947.
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    83. Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. Development. 2005 May; 132(10):2425-39. Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM, Wechsler-Reya RJ. PMID: 15843415.
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    84. Getting at the root and stem of brain tumors. Neuron. 2004 Jun 24; 42(6):885-8. Oliver TG, Wechsler-Reya RJ. PMID: 15207233.
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    85. Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7331-6. Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP, Wechsler-Reya RJ. PMID: 12777630.
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    86. Analysis of gene expression in the normal and malignant cerebellum. Recent Prog Horm Res. 2003; 58:227-48. Wechsler-Reya RJ. PMID: 12795421.
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    87. Caught in the matrix: how vitronectin controls neuronal differentiation. Trends Neurosci. 2001 Dec; 24(12):680-2. Wechsler-Reya RJ. PMID: 11718852.
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    88. The developmental biology of brain tumors. Annu Rev Neurosci. 2001; 24:385-428. Wechsler-Reya R, Scott MP. PMID: 11283316.
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    89. Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. Genes Chromosomes Cancer. 2000 May; 28(1):77-81. Zurawel RH, Allen C, Wechsler-Reya R, Scott MP, Raffel C. PMID: 10738305.
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    90. Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity. Int J Cancer. 2000 Feb 01; 85(3):376-83. Ge K, Duhadaway J, Sakamuro D, Wechsler-Reya R, Reynolds C, Prendergast GC. PMID: 10652430.
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    91. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron. 1999 Jan; 22(1):103-14. Wechsler-Reya RJ, Scott MP. PMID: 10027293.
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    92. A role for the putative tumor suppressor Bin1 in muscle cell differentiation. Mol Cell Biol. 1998 Jan; 18(1):566-75. Wechsler-Reya RJ, Elliott KJ, Prendergast GC. PMID: 9418903.
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    93. Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. J Biol Chem. 1997 Dec 12; 272(50):31453-8. Wechsler-Reya R, Sakamuro D, Zhang J, Duhadaway J, Prendergast GC. PMID: 9395479.
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    94. The putative tumor suppressor BIN1 is a short-lived nuclear phosphoprotein, the localization of which is altered in malignant cells. Cancer Res. 1997 Aug 01; 57(15):3258-63. Wechsler-Reya R, Elliott K, Herlyn M, Prendergast GC. PMID: 9242458.
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    95. Retinal development: communication helps you see the light. Curr Biol. 1997 Jul 01; 7(7):R433-6. Wechsler-Reya RJ, Barres BA. PMID: 9210366.
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    96. Lipopolysaccharide prevents apoptosis and induces responsiveness to antigen receptor cross-linking in immature B cells. Immunology. 1996 Nov; 89(3):356-62. Wechsler-Reya RJ, Monroe JG. PMID: 8958047.
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    97. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet. 1996 Sep; 14(1):69-77. Sakamuro D, Elliott KJ, Wechsler-Reya R, Prendergast GC. PMID: 8782822.
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    98. Immature stage B cells enter but do not progress beyond the early G1 phase of the cell cycle in response to antigen receptor signaling. J Immunol. 1996 Jun 15; 156(12):4562-9. Carman JA, Wechsler-Reya RJ, Monroe JG. PMID: 8648097.
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    99. Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors. Cancer Res. 1996 Jun 01; 56(11):2626-32. Prendergast GC, Davide JP, Lebowitz PF, Wechsler-Reya R, Kohl NE. PMID: 8653708.
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    100. The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. Genomics. 1996 Apr 15; 33(2):329-31. Negorev D, Riethman H, Wechsler-Reya R, Sakamuro D, Prendergast GC, Simon D. PMID: 8725406.
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