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Sara Weis

Title(s), Pathology
SchoolHealth Sciences
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-822-2488
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of VEGF-induced vascular permeability
    NIH/NHLBI F32HL069701Jan 29, 2002
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin avß5 Axis. Cell Stem Cell. 2020 Feb 06; 26(2):187-204.e10. Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038.
      View in: PubMed   Mentions: 3     Fields:    
    2. Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression. Cancer Res. 2019 10 01; 79(19):5048-5059. Wettersten HI, Weis SM, Pathria P, Von Schalscha T, Minami T, Varner JA, Cheresh DA. PMID: 31416839.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Re-thinking the preclinical development of GBM therapeutics. Oncoscience. 2018 Jan; 5(1-2):11-12. Cosset É, Weis SM, Cheresh DA. PMID: 29556513.
      View in: PubMed   Mentions:
    4. Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma. Cancer Cell. 2017 Dec 11; 32(6):856-868.e5. Cosset É, Ilmjärv S, Dutoit V, Elliott K, von Schalscha T, Camargo MF, Reiss A, Moroishi T, Seguin L, Gomez G, Moo JS, Preynat-Seauve O, Krause KH, Chneiweiss H, Sarkaria JN, Guan KL, Dietrich PY, Weis SM, Mischel PS, Cheresh DA. PMID: 29198914.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    5. Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers. Cancer Discov. 2017 12; 7(12):1464-1479. Seguin L, Camargo MF, Wettersten HI, Kato S, Desgrosellier JS, von Schalscha T, Elliott KC, Cosset E, Lesperance J, Weis SM, Cheresh DA. PMID: 28893801.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    6. MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat Commun. 2016 11 25; 7:13597. Wilson R, Espinosa-Diez C, Kanner N, Chatterjee N, Ruhl R, Hipfinger C, Advani SJ, Li J, Khan OF, Franovic A, Weis SM, Kumar S, Coussens LM, Anderson DG, Chen CC, Cheresh DA, Anand S. PMID: 27886180.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    7. Kinase-independent role for CRAF-driving tumour radioresistance via CHK2. Nat Commun. 2015 Sep 03; 6:8154. Advani SJ, Camargo MF, Seguin L, Mielgo A, Anand S, Hicks AM, Aguilera J, Franovic A, Weis SM, Cheresh DA. PMID: 26333361.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    8. Glioblastomas require integrin avß3/PAK4 signaling to escape senescence. Cancer Res. 2015 Nov 01; 75(21):4466-73. Franovic A, Elliott KC, Seguin L, Camargo MF, Weis SM, Cheresh DA. PMID: 26297735.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance. Trends Cell Biol. 2015 Apr; 25(4):234-40. Seguin L, Desgrosellier JS, Weis SM, Cheresh DA. PMID: 25572304.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansCells
    10. Targeting the Achilles' heel of drug-resistant cancer stem cells. Cell Cycle. 2014; 13(13):2017-8. Seguin L, Gozo M, Weis SM, Cheresh DA. PMID: 24906000.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. Variety in the tumor microenvironment: integrin splicing regulates stemness. Cell Stem Cell. 2014 May 01; 14(5):557-8. Seguin L, Weis SM, Cheresh DA. PMID: 24792112.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. An integrin ß3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol. 2014 May; 16(5):457-68. Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, Yebra M, Mielgo A, Lowy AM, Husain H, Cascone T, Diao L, Wang J, Wistuba II, Heymach JV, Lippman SM, Desgrosellier JS, Anand S, Weis SM, Cheresh DA. PMID: 24747441.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    13. Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J Cell Biol. 2014 Jan 20; 204(2):247-63. Jean C, Chen XL, Nam JO, Tancioni I, Uryu S, Lawson C, Ward KK, Walsh CT, Miller NL, Ghassemian M, Turowski P, Dejana E, Weis S, Cheresh DA, Schlaepfer DD. PMID: 24446483.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    14. A wake-up call for hibernating tumour cells. Nat Cell Biol. 2013 Jul; 15(7):721-3. Weis SM, Cheresh DA. PMID: 23817234.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    15. Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. J Cell Biol. 2012 Jun 25; 197(7):907-19. Lim ST, Miller NL, Chen XL, Tancioni I, Walsh CT, Lawson C, Uryu S, Weis SM, Cheresh DA, Schlaepfer DD. PMID: 22734001.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    16. EGFR-mediated carcinoma cell metastasis mediated by integrin avß5 depends on activation of c-Src and cleavage of MUC1. PLoS One. 2012; 7(5):e36753. Lau SK, Shields DJ, Murphy EA, Desgrosellier JS, Anand S, Huang M, Kato S, Lim ST, Weis SM, Stupack DG, Schlaepfer DD, Cheresh DA. PMID: 22586492.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    17. VEGF-induced vascular permeability is mediated by FAK. Dev Cell. 2012 Jan 17; 22(1):146-57. Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD. PMID: 22264731.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    18. Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane. Blood. 2012 Mar 01; 119(9):2149-58. Scheppke L, Murphy EA, Zarpellon A, Hofmann JJ, Merkulova A, Shields DJ, Weis SM, Byzova TV, Ruggeri ZM, Iruela-Arispe ML, Cheresh DA. PMID: 22134168.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    19. A MEK-independent role for CRAF in mitosis and tumor progression. Nat Med. 2011 Nov 13; 17(12):1641-5. Mielgo A, Seguin L, Huang M, Camargo MF, Anand S, Franovic A, Weis SM, Advani SJ, Murphy EA, Cheresh DA. PMID: 22081024.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    20. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med. 2011 Nov 07; 17(11):1359-70. Weis SM, Cheresh DA. PMID: 22064426.
      View in: PubMed   Mentions: 431     Fields:    Translation:HumansCells
    21. aV integrins in angiogenesis and cancer. Cold Spring Harb Perspect Med. 2011 Sep; 1(1):a006478. Weis SM, Cheresh DA. PMID: 22229119.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    22. A Src family kinase inhibitor improves survival in experimental acute liver failure associated with elevated cerebral and circulating vascular endothelial growth factor levels. Liver Int. 2011 Sep; 31(8):1222-30. Aspinall RJ, Weis SM, Barnes L, Lutu-Fuga K, Bylund DJ, Pockros PJ, Cheresh DA. PMID: 21745297.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. Evaluation of VEGF-induced vascular permeability in mice. Methods Mol Biol. 2011; 763:403-15. Weis SM. PMID: 21874467.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med. 2010 Aug; 16(8):909-14. Anand S, Majeti BK, Acevedo LM, Murphy EA, Mukthavaram R, Scheppke L, Huang M, Shields DJ, Lindquist JN, Lapinski PE, King PD, Weis SM, Cheresh DA. PMID: 20676106.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    25. Agonizing integrin antagonists? Cancer Cell. 2009 May 05; 15(5):359-61. Weis SM, Stupack DG, Cheresh DA. PMID: 19411065.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    26. Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. Cancer Res. 2009 Feb 15; 69(4):1383-91. Ricono JM, Huang M, Barnes LA, Lau SK, Weis SM, Schlaepfer DD, Hanks SK, Cheresh DA. PMID: 19208836.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    27. Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9343-8. Murphy EA, Majeti BK, Barnes LA, Makale M, Weis SM, Lutu-Fuga K, Wrasidlo W, Cheresh DA. PMID: 18607000.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    28. Vascular permeability in cardiovascular disease and cancer. Curr Opin Hematol. 2008 May; 15(3):243-9. Weis SM. PMID: 18391792.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    29. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol. 2008 Apr 07; 181(1):43-50. Weis SM, Lim ST, Lutu-Fuga KM, Barnes LA, Chen XL, Göthert JR, Shen TL, Guan JL, Schlaepfer DD, Cheresh DA. PMID: 18391070.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    30. Robo4 counteracts VEGF signaling. Nat Med. 2008 Apr; 14(4):372-3. Acevedo LM, Weis SM, Cheresh DA. PMID: 18391935.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    31. Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor. Blood. 2008 Mar 01; 111(5):2674-80. Acevedo LM, Barillas S, Weis SM, Göthert JR, Cheresh DA. PMID: 18180379.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    32. Chapter 5. Evaluating vascular leak in vivo. Methods Enzymol. 2008; 444:99-114. Weis SM. PMID: 19007662.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    33. Evaluating integrin function in models of angiogenesis and vascular permeability. Methods Enzymol. 2007; 426:505-28. Weis SM. PMID: 17697897.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    34. Cooperation between VEGF and beta3 integrin during cardiac vascular development. Blood. 2007 Mar 01; 109(5):1962-70. Weis SM, Lindquist JN, Barnes LA, Lutu-Fuga KM, Cui J, Wood MR, Cheresh DA. PMID: 17062734.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    35. Pathophysiological consequences of VEGF-induced vascular permeability. Nature. 2005 Sep 22; 437(7058):497-504. Weis SM, Cheresh DA. PMID: 16177780.
      View in: PubMed   Mentions: 234     Fields:    Translation:HumansAnimalsCells
    36. A role for decorin in the remodeling of myocardial infarction. Matrix Biol. 2005 Jun; 24(4):313-24. Weis SM, Zimmerman SD, Shah M, Covell JW, Omens JH, Ross J, Dalton N, Jones Y, Reed CC, Iozzo RV, McCulloch AD. PMID: 15949932.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals