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Karen Pierce

Title(s)Professor In Residence, Neurosciences
SchoolHealth Sciences
Phone858-534-6919
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    Discovering Eye Tracking Biomarkers of ASD with Diagnostic and Prognostic Power
    NIH/NIMH R01MH118879Feb 1, 2019 - Nov 30, 2023
    Role: Principal Investigator
    Discovering Neural Biomarkers of Language and Social Development in ASD Toddlers
    NIH/NIDCD R01DC016385Sep 1, 2017 - Aug 31, 2022
    Role: Co-Principal Investigator
    Detection of ASD at the 1st birthday as standard of care: The Get SET Early Model
    NIH/NIMH R01MH104446Aug 25, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Early Identification of ASD: Translating Eye Tracking into Practice
    NIH/NIMH R01MH080134Dec 17, 2007 - May 31, 2018
    Role: Principal Investigator
    Biomarkers of Autism at 12 months: From Brain Overgrowth to Genes
    NIH/NIMH P50MH081755Aug 6, 2007 - Jun 30, 2014
    Role: Co-Investigator
    SOCIAL PERCEPTION IN AUTISM: A FMRI INVESTIGATION
    NIH/NIMH K01MH001814Dec 10, 1999 - Jul 31, 2006
    Role: Principal Investigator
    SOCIAL PERCEPTION AND ATTENTION IN AUTISM
    NIH/NIMH F32MH011298Mar 1, 1996
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wolraich ML, Hagan JF, Allan C, Chan E, Davison D, Earls M, Evans SW, Flinn SK, Froehlich T, Frost J, Holbrook JR, Lehmann CU, Lessin HR, Okechukwu K, Pierce KL, Winner JD, Zurhellen W. Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents. Pediatrics. 2019 Oct; 144(4). PMID: 31570648.
      View in: PubMed
    2. Gazestani VH, Pramparo T, Nalabolu S, Kellman BP, Murray S, Lopez L, Pierce K, Courchesne E, Lewis NE. A perturbed gene network containing PI3K-AKT, RAS-ERK and WNT-ß-catenin pathways in leukocytes is linked to ASD genetics and symptom severity. Nat Neurosci. 2019 Oct; 22(10):1624-1634. PMID: 31551593.
      View in: PubMed
    3. Pierce K, Gazestani VH, Bacon E, Barnes CC, Cha D, Nalabolu S, Lopez L, Moore A, Pence-Stophaeros S, Courchesne E. Evaluation of the Diagnostic Stability of the Early Autism Spectrum Disorder Phenotype in the General Population Starting at 12 Months. JAMA Pediatr. 2019 Apr 29. PMID: 31034004.
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    4. Kwon MK, Moore A, Barnes CC, Cha D, Pierce K. Typical Levels of Eye-Region Fixation in Toddlers With ASD Across Multiple Contexts. J Am Acad Child Adolesc Psychiatry. 2019 Mar 06. PMID: 30851395.
      View in: PubMed
    5. Lombardo MV, Pramparo T, Gazestani V, Warrier V, Bethlehem RAI, Carter Barnes C, Lopez L, Lewis NE, Eyler L, Pierce K, Courchesne E. Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes. Nat Neurosci. 2018 Dec; 21(12):1680-1688. PMID: 30482947.
      View in: PubMed
    6. Courchesne E, Pramparo T, Gazestani VH, Lombardo MV, Pierce K, Lewis NE. The ASD Living Biology: from cell proliferation to clinical phenotype. Mol Psychiatry. 2019 01; 24(1):88-107. PMID: 29934544.
      View in: PubMed
    7. Bacon EC, Osuna S, Courchesne E, Pierce K. Naturalistic language sampling to characterize the language abilities of 3-year-olds with autism spectrum disorder. Autism. 2018 May 01; 1362361318766241. PMID: 29754501.
      View in: PubMed
    8. Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J. Paternally inherited cis-regulatory structural variants are associated with autism. Science. 2018 04 20; 360(6386):327-331. PMID: 29674594.
      View in: PubMed
    9. Broder Fingert S, Carter A, Pierce K, Stone WL, Wetherby A, Scheldrick C, Smith C, Bacon E, James SN, Ibañez L, Feinberg E. Implementing systems-based innovations to improve access to early screening, diagnosis, and treatment services for children with autism spectrum disorder: An Autism Spectrum Disorder Pediatric, Early Detection, Engagement, and Services network study. Autism. 2019 Apr; 23(3):653-664. PMID: 29633852.
      View in: PubMed
    10. Moore A, Wozniak M, Yousef A, Barnes CC, Cha D, Courchesne E, Pierce K. The geometric preference subtype in ASD: identifying a consistent, early-emerging phenomenon through eye tracking. Mol Autism. 2018; 9:19. PMID: 29581878.
      View in: PubMed
    11. Bacon EC, Courchesne E, Barnes CC, Cha D, Pence S, Schreibman L, Stahmer AC, Pierce K. Rethinking the idea of late autism spectrum disorder onset. Dev Psychopathol. 2018 05; 30(2):553-569. PMID: 28803559.
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    12. Geisheker MR, Heymann G, Wang T, Coe BP, Turner TN, Stessman HAF, Hoekzema K, Kvarnung M, Shaw M, Friend K, Liebelt J, Barnett C, Thompson EM, Haan E, Guo H, Anderlid BM, Nordgren A, Lindstrand A, Vandeweyer G, Alberti A, Avola E, Vinci M, Giusto S, Pramparo T, Pierce K, Nalabolu S, Michaelson JJ, Sedlacek Z, Santen GWE, Peeters H, Hakonarson H, Courchesne E, Romano C, Kooy RF, Bernier RA, Nordenskjöld M, Gecz J, Xia K, Zweifel LS, Eichler EE. Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains. Nat Neurosci. 2017 Aug; 20(8):1043-1051. PMID: 28628100.
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    13. Stessman HA, Xiong B, Coe BP, Wang T, Hoekzema K, Fenckova M, Kvarnung M, Gerdts J, Trinh S, Cosemans N, Vives L, Lin J, Turner TN, Santen G, Ruivenkamp C, Kriek M, van Haeringen A, Aten E, Friend K, Liebelt J, Barnett C, Haan E, Shaw M, Gecz J, Anderlid BM, Nordgren A, Lindstrand A, Schwartz C, Kooy RF, Vandeweyer G, Helsmoortel C, Romano C, Alberti A, Vinci M, Avola E, Giusto S, Courchesne E, Pramparo T, Pierce K, Nalabolu S, Amaral DG, Scheffer IE, Delatycki MB, Lockhart PJ, Hormozdiari F, Harich B, Castells-Nobau A, Xia K, Peeters H, Nordenskjöld M, Schenck A, Bernier RA, Eichler EE. Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases. Nat Genet. 2017 Apr; 49(4):515-526. PMID: 28191889.
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    14. Fingher N, Dinstein I, Ben-Shachar M, Haar S, Dale AM, Eyler L, Pierce K, Courchesne E. Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers. Cortex. 2017 12; 97:291-305. PMID: 28202133.
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    15. Pierce K, Courchesne E, Bacon E. To Screen or Not to Screen Universally for Autism is not the Question: Why the Task Force Got It Wrong. J Pediatr. 2016 09; 176:182-94. PMID: 27421956.
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    16. Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Mol Psychiatry. 2017 06; 22(6):820-835. PMID: 27378147.
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    17. Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J. Frequency and Complexity of De Novo Structural Mutation in Autism. Am J Hum Genet. 2016 Apr 07; 98(4):667-79. PMID: 27018473.
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    18. Pramparo T, Lombardo MV, Campbell K, Barnes CC, Marinero S, Solso S, Young J, Mayo M, Dale A, Ahrens-Barbeau C, Murray SS, Lopez L, Lewis N, Pierce K, Courchesne E. Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers. Mol Syst Biol. 2015 Dec 14; 11(12):841. PMID: 26668231.
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    19. Zwaigenbaum L, Bauman ML, Fein D, Pierce K, Buie T, Davis PA, Newschaffer C, Robins DL, Wetherby A, Choueiri R, Kasari C, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Carter A, Granpeesheh D, Mailloux Z, Smith Roley S, Wagner S. Early Screening of Autism Spectrum Disorder: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S41-59. PMID: 26430169.
      View in: PubMed
    20. Zwaigenbaum L, Bauman ML, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Choueiri R, Fein D, Kasari C, Pierce K, Buie T, Carter A, Davis PA, Granpeesheh D, Mailloux Z, Newschaffer C, Robins D, Roley SS, Wagner S, Wetherby A. Early Identification of Autism Spectrum Disorder: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S10-40. PMID: 26430168.
      View in: PubMed
    21. Zwaigenbaum L, Bauman ML, Choueiri R, Kasari C, Carter A, Granpeesheh D, Mailloux Z, Smith Roley S, Wagner S, Fein D, Pierce K, Buie T, Davis PA, Newschaffer C, Robins D, Wetherby A, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR. Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research. Pediatrics. 2015 Oct; 136 Suppl 1:S60-81. PMID: 26430170.
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    22. Zwaigenbaum L, Bauman ML, Choueiri R, Fein D, Kasari C, Pierce K, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MR, Buie T, Carter A, Davis PA, Granpeesheh D, Mailloux Z, Newschaffer C, Robins D, Smith Roley S, Wagner S, Wetherby A. Early Identification and Interventions for Autism Spectrum Disorder: Executive Summary. Pediatrics. 2015 Oct; 136 Suppl 1:S1-9. PMID: 26430167.
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    23. Solso S, Xu R, Proudfoot J, Hagler DJ, Campbell K, Venkatraman V, Carter Barnes C, Ahrens-Barbeau C, Pierce K, Dale A, Eyler L, Courchesne E. Diffusion Tensor Imaging Provides Evidence of Possible Axonal Overconnectivity in Frontal Lobes in Autism Spectrum Disorder Toddlers. Biol Psychiatry. 2016 Apr 15; 79(8):676-84. PMID: 26300272.
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    24. Pierce K, Marinero S, Hazin R, McKenna B, Barnes CC, Malige A. Eye Tracking Reveals Abnormal Visual Preference for Geometric Images as an Early Biomarker of an Autism Spectrum Disorder Subtype Associated With Increased Symptom Severity. Biol Psychiatry. 2016 Apr 15; 79(8):657-66. PMID: 25981170.
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    25. Lombardo MV, Pierce K, Eyler LT, Carter Barnes C, Ahrens-Barbeau C, Solso S, Campbell K, Courchesne E. Different functional neural substrates for good and poor language outcome in autism. Neuron. 2015 Apr 22; 86(2):567-77. PMID: 25864635.
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    26. Pramparo T, Pierce K, Lombardo MV, Carter Barnes C, Marinero S, Ahrens-Barbeau C, Murray SS, Lopez L, Xu R, Courchesne E. Prediction of autism by translation and immune/inflammation coexpressed genes in toddlers from pediatric community practices. JAMA Psychiatry. 2015 Apr; 72(4):386-94. PMID: 25739104.
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    27. Woods D, Wolraich M, Pierce K, DiMarco L, Muller N, Sachdeva R. Considerations and evidence for an ADHD outcome measure. Acad Pediatr. 2014 Sep-Oct; 14(5 Suppl):S54-60. PMID: 25169459.
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    28. Bacon EC, Dufek S, Schreibman L, Stahmer AC, Pierce K, Courchesne E. Measuring outcome in an early intervention program for toddlers with autism spectrum disorder: use of a curriculum-based assessment. Autism Res Treat. 2014; 2014:964704. PMID: 24711926.
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    29. Glatt SJ, Tsuang MT, Winn M, Chandler SD, Collins M, Lopez L, Weinfeld M, Carter C, Schork N, Pierce K, Courchesne E. Blood-based gene expression signatures of infants and toddlers with autism. J Am Acad Child Adolesc Psychiatry. 2012 Sep; 51(9):934-44.e2. PMID: 22917206.
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    30. Eyler LT, Pierce K, Courchesne E. A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism. Brain. 2012 Mar; 135(Pt 3):949-60. PMID: 22350062.
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    31. Courchesne E, Mouton PR, Calhoun ME, Semendeferi K, Ahrens-Barbeau C, Hallet MJ, Barnes CC, Pierce K. Neuron number and size in prefrontal cortex of children with autism. JAMA. 2011 Nov 09; 306(18):2001-10. PMID: 22068992.
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    32. Pierce K. Treatment of attention-deficit/hyperactivity disorder. Pediatr Ann. 2011 Nov; 40(11):556-62. PMID: 22066507.
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    33. Wolraich M, Brown L, Brown RT, DuPaul G, Earls M, Feldman HM, Ganiats TG, Kaplanek B, Meyer B, Perrin J, Pierce K, Reiff M, Stein MT, Visser S. ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics. 2011 Nov; 128(5):1007-22. PMID: 22003063.
      View in: PubMed
    34. Dinstein I, Pierce K, Eyler L, Solso S, Malach R, Behrmann M, Courchesne E. Disrupted neural synchronization in toddlers with autism. Neuron. 2011 Jun 23; 70(6):1218-25. PMID: 21689606.
      View in: PubMed
    35. Pierce K, Carter C, Weinfeld M, Desmond J, Hazin R, Bjork R, Gallagher N. Detecting, studying, and treating autism early: the one-year well-baby check-up approach. J Pediatr. 2011 Sep; 159(3):458-465.e1-6. PMID: 21524759.
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    36. Pierce K. Early functional brain development in autism and the promise of sleep fMRI. Brain Res. 2011 Mar 22; 1380:162-74. PMID: 20869953.
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    37. Pierce K, Conant D, Hazin R, Stoner R, Desmond J. Preference for geometric patterns early in life as a risk factor for autism. Arch Gen Psychiatry. 2011 Jan; 68(1):101-9. PMID: 20819977.
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    38. Schumann CM, Bloss CS, Barnes CC, Wideman GM, Carper RA, Akshoomoff N, Pierce K, Hagler D, Schork N, Lord C, Courchesne E. Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism. J Neurosci. 2010 Mar 24; 30(12):4419-27. PMID: 20335478.
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    39. Pierce K, Glatt SJ, Liptak GS, McIntyre LL. The power and promise of identifying autism early: insights from the search for clinical and biological markers. Ann Clin Psychiatry. 2009 Jul-Sep; 21(3):132-47. PMID: 19758535.
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    40. Luyster R, Gotham K, Guthrie W, Coffing M, Petrak R, Pierce K, Bishop S, Esler A, Hus V, Oti R, Richler J, Risi S, Lord C. The Autism Diagnostic Observation Schedule-toddler module: a new module of a standardized diagnostic measure for autism spectrum disorders. J Autism Dev Disord. 2009 Sep; 39(9):1305-20. PMID: 19415479.
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    41. Pierce K, Redcay E. Fusiform function in children with an autism spectrum disorder is a matter of "who". Biol Psychiatry. 2008 Oct 01; 64(7):552-60. PMID: 18621359.
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    42. Courchesne E, Pierce K, Schumann CM, Redcay E, Buckwalter JA, Kennedy DP, Morgan J. Mapping early brain development in autism. Neuron. 2007 Oct 25; 56(2):399-413. PMID: 17964254.
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    43. Brown RT, Amler RW, Freeman WS, Perrin JM, Stein MT, Feldman HM, Pierce K, Wolraich ML. Treatment of attention-deficit/hyperactivity disorder: overview of the evidence. Pediatrics. 2005 Jun; 115(6):e749-57. PMID: 15930203.
      View in: PubMed
    44. Courchesne E, Pierce K. Brain overgrowth in autism during a critical time in development: implications for frontal pyramidal neuron and interneuron development and connectivity. Int J Dev Neurosci. 2005 Apr-May; 23(2-3):153-70. PMID: 15749242.
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    45. Courchesne E, Pierce K. Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection. Curr Opin Neurobiol. 2005 Apr; 15(2):225-30. PMID: 15831407.
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    46. Teder-Sälejärvi WA, Pierce KL, Courchesne E, Hillyard SA. Auditory spatial localization and attention deficits in autistic adults. Brain Res Cogn Brain Res. 2005 May; 23(2-3):221-34. PMID: 15820630.
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    47. Pierce K, Haist F, Sedaghat F, Courchesne E. The brain response to personally familiar faces in autism: findings of fusiform activity and beyond. Brain. 2004 Dec; 127(Pt 12):2703-16. PMID: 15319275.
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    48. Müller RA, Kleinhans N, Kemmotsu N, Pierce K, Courchesne E. Abnormal variability and distribution of functional maps in autism: an FMRI study of visuomotor learning. Am J Psychiatry. 2003 Oct; 160(10):1847-62. PMID: 14514501.
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    49. Müller RA, Kleinhans N, Pierce K, Kemmotsu N, Courchesne E. Functional MRI of motor sequence acquisition: effects of learning stage and performance. Brain Res Cogn Brain Res. 2002 Aug; 14(2):277-93. PMID: 12067701.
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    50. Akshoomoff N, Pierce K, Courchesne E. The neurobiological basis of autism from a developmental perspective. Dev Psychopathol. 2002; 14(3):613-34. PMID: 12349876.
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    51. Luttrell LM, Roudabush FL, Choy EW, Miller WE, Field ME, Pierce KL, Lefkowitz RJ. Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2449-54. PMID: 11226259.
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    52. Sherer M, Pierce KL, Paredes S, Kisacky KL, Ingersoll B, Schreibman L. Enhancing conversation skills in children with autism via video technology. Which is better, "self" or "other" as a model? Behav Modif. 2001 Jan; 25(1):140-58. PMID: 11151482.
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    53. Cao W, Luttrell LM, Medvedev AV, Pierce KL, Daniel KW, Dixon TM, Lefkowitz RJ, Collins S. Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. J Biol Chem. 2000 Dec 08; 275(49):38131-4. PMID: 11013230.
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    54. Pierce KL, Schreibman L. Teaching daily living skills to children with autism in unsupervised settings through pictorial self-management. J Appl Behav Anal. 1994; 27(3):471-81. PMID: 7928790.
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