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William Mobley

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentNeurosciences
Address9500 Gilman Drive #0752
La Jolla CA 92093
Phone858-534-9434
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    Collapse Research 
    Collapse Research Activities and Funding
    Treating with Gamma-Secretase Modulators to Prevent Neurodegeneration in Mouse Models of Down Syndrome and Alzheimer Disease
    NIH/NIA R01AG055523May 1, 2018 - Jan 31, 2023
    Role: Principal Investigator
    From Structure to Therapy: The TRiC Chaperonin Network in Huntington's Disease
    NIH/NINDS P01NS092525Apr 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    Genetic Basis of Failed Cognition in Young and Aged Mouse Models of Trisomy 21
    NIH/NINDS R01NS066072Sep 30, 2010 - Jul 31, 2015
    Role: Principal Investigator
    2009 Neurotrophic Factors Gordon Research Conference
    NIH/NINDS R13NS065502Apr 1, 2009 - Mar 31, 2010
    Role: Principal Investigator
    Disrupted Transport of NGF-TrKA Signaling in Mouse Models of Down Syndrome
    NIH/NINDS R01NS055371May 7, 2007 - Apr 30, 2012
    Role: Principal Investigator
    Training in Translational Develomental Neuroscience
    NIH/NINDS K12NS049648Aug 15, 2004 - Jun 30, 2010
    Role: Principal Investigator
    University of California, San Diego Neuroscience Microscopy Imaging Core
    NIH/NINDS P30NS047101Sep 30, 2003 - Nov 30, 2021
    Role: Principal Investigator
    MAPPING DS RELATED CNS PHENOTYPES
    NIH/NINDS R01NS038869Mar 1, 1999 - Feb 28, 2005
    Role: Principal Investigator
    NGF SIGNALING IN MODELS OF AGE RELATED NEURODEGENERATION
    NIH/NIA R01AG016999Sep 15, 1998 - Aug 31, 2005
    Role: Principal Investigator
    Alzheimer's Disease Cooperative Study
    NIH/NIA U19AG010483Jul 1, 1997 - Feb 28, 2018
    Role: Principal Investigator
    Translating discoveries in neurological diseases of infancy and childhood
    NIH/NINDS K12NS001692Jul 1, 1993 - Jun 30, 2019
    Role: Principal Investigator
    NEUROTROPHIC FACTOR THERAPY FOR ALZHEIMERS DISEASE
    NIH/NIA R01AG010672Sep 29, 1991 - Jun 30, 1997
    Role: Principal Investigator
    Scientific Review and Evaluation Award - NST Committee
    NIH/NINDS U09NS030469Jul 1, 1991 - Aug 31, 2006
    Role: Principal Investigator
    Nerve Growth Factor-Mechanisms for Signal Transduction
    NIH/NINDS R01NS024054Jul 1, 1986 - Sep 30, 2009
    Role: Principal Investigator
    NERVE GROWTH FACTOR--EFFECTS ON DEVELOPING CNS NEURONS
    NIH/NINDS K08NS001015Jul 1, 1985 - Jun 30, 1988
    Role: Principal Investigator
    3 D Electron Microscopy of Macromolecules
    NIH P41RR002250Mar 1, 1985 - Dec 31, 2014
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. TRiC enhances retrograde axonal transport by modulating tau phosphorylation. Traffic. 2018 Aug 17. PMID: 30120810.
      View in: PubMed
    2. Jiang X, Xiao H, Segal R, Mobley WC, Park H. Trends in Readmission Rates, Hospital Charges, and Mortality for Patients With Chronic Obstructive Pulmonary Disease (COPD) in Florida From 2009 to 2014. Clin Ther. 2018 Apr; 40(4):613-626.e1. PMID: 29609879.
      View in: PubMed
    3. Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn ML, Maloney MT, Mobley WC, Levine JD, Wu C. Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception. J Neurosci. 2018 Apr 04; 38(14):3394-3413. PMID: 29483280.
      View in: PubMed
    4. Chen XQ, Sawa M, Mobley WC. Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome. Free Radic Biol Med. 2018 Jan; 114:52-61. PMID: 29031834.
      View in: PubMed
    5. Bradshaw RA, Mobley W, Rush RA. Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series. Int J Mol Sci. 2017 May 26; 18(6). PMID: 28587118.
      View in: PubMed
    6. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. Pharmacological and Toxicological Properties of the Potent Oral ?-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 Jul; 362(1):31-44. PMID: 28416568.
      View in: PubMed
    7. Kleschevnikov AM, Yu J, Kim J, Lysenko LV, Zeng Z, Yu YE, Mobley WC. Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2017 Jul; 103:1-10. PMID: 28342823.
      View in: PubMed
    8. Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC. PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2017; 60(2):439-450. PMID: 28946567.
      View in: PubMed
    9. Xing Z, Li Y, Pao A, Bennett AS, Tycko B, Mobley WC, Yu YE. Mouse-based genetic modeling and analysis of Down syndrome. Br Med Bull. 2016 Dec; 120(1):111-122. PMID: 27789459.
      View in: PubMed
    10. Mojabi FS, Fahimi A, Moghadam S, Moghadam S, Windy McNerneny M, Ponnusamy R, Kleschevnikov A, Mobley WC, Salehi A. GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App. Hippocampus. 2016 12; 26(12):1641-1654. PMID: 27701794.
      View in: PubMed
    11. Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC. TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5655-64. PMID: 27601642.
      View in: PubMed
    12. Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman RA, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS. Dissociation of Down syndrome and Alzheimer's disease effects with imaging. Alzheimers Dement (N Y). 2016 Jun; 2(2):69-81. PMID: 28642933.
      View in: PubMed
    13. Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to ß-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genet. 2016 May; 12(5):e1006033. PMID: 27195491; PMCID: PMC4873152.
    14. Xu W, Weissmiller AM, White JA, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest. 2016 May 02; 126(5):1815-33. PMID: 27064279; PMCID: PMC4855914.
    15. Ballard C, Mobley W, Hardy J, Williams G, Corbett A. Dementia in Down's syndrome. Lancet Neurol. 2016 May; 15(6):622-36. PMID: 27302127.
      View in: PubMed
    16. Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SK, Linke GR, Maloney MT, Hickman DT, Reis P, Granet A, Mlaki D, Lopez-Deber MP, Do L, Singhal N, Masliah E, Pearn ML, Pfeifer A, Muhs A, Mobley WC. An Anti-ß-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. PLoS One. 2016; 11(3):e0152471. PMID: 27023444; PMCID: PMC4811554.
    17. Jiang X, Liu C, Yu T, Zhang L, Meng K, Xing Z, Belichenko PV, Kleschevnikov AM, Pao A, Peresie J, Wie S, Mobley WC, Yu YE. Genetic dissection of the Down syndrome critical region. Hum Mol Genet. 2015 Nov 15; 24(22):6540-51. PMID: 26374847; PMCID: PMC4614710 [Available on 11/15/16].
    18. Rafii MS, Wishnek H, Brewer JB, Donohue MC, Ness S, Mobley WC, Aisen PS, Rissman RA. The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci. 2015; 9:239. PMID: 26441570; PMCID: PMC4568340.
    19. Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, St George-Hyslop P, Masliah E, Fraser P, Xu H. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 2015 Sep 02; 87(5):963-75. PMID: 26335643.
      View in: PubMed
    20. Belichenko PV, Kleschevnikov AM, Becker A, Wagner GE, Lysenko LV, Yu YE, Mobley WC. Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues. PLoS One. 2015; 10(7):e0134861. PMID: 26230397; PMCID: PMC4521889.
    21. Do LH, Mobley WC, Singhal N. Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome. F1000Res. 2015; 4:269. PMID: 26664707.
      View in: PubMed
    22. Do L, Mobley W. Single Figure Publications: Towards a novel alternative format for scholarly communication. F1000Res. 2015; 4:268. PMID: 27506233; PMCID: PMC4786890.
    23. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. A ?-secretase inhibitor, but not a ?-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. PMID: 25710492; PMCID: PMC4339551.
    24. Selfridge A, Hyun N, Chiang CC, Reyna SM, Weissmiller AM, Shi LZ, Preece D, Mobley WC, Berns MW. Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy. Neurophotonics. 2015 Jan; 2(1):015006. PMID: 26157985; PMCID: PMC4487718.
    25. Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimers Dement. 2015 Jun; 11(6):700-9. PMID: 25510383; PMCID: PMC4817997.
    26. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimers Dement. 2014 Oct; 10(5 Suppl):S430-52. PMID: 25341459.
      View in: PubMed
    27. Zhao X, Zhou Y, Weissmiller AM, Pearn ML, Mobley WC, Wu C. Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. J Vis Exp. 2014 Sep 15; (91):51899. PMID: 25286194; PMCID: PMC4828072.
    28. Shahmoradian SH, Galiano MR, Wu C, Chen S, Rasband MN, Mobley WC, Chiu W. Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. J Vis Exp. 2014 Feb 12; (84):e50783. PMID: 24561719; PMCID: PMC4089403.
    29. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species. Biochemistry. 2014 Feb 04; 53(4):702-13. PMID: 24401146; PMCID: PMC3929337.
    30. Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Oct 16; 80(2):270-4. PMID: 24139032.
      View in: PubMed
    31. Zhang L, Meng K, Jiang X, Liu C, Pao A, Belichenko PV, Kleschevnikov AM, Josselyn S, Liang P, Ye P, Mobley WC, Yu YE. Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. Hum Mol Genet. 2014 Feb 01; 23(3):578-89. PMID: 24041763; PMCID: PMC3888256.
    32. Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr; 19(4):473-80. PMID: 23524343; PMCID: PMC3911880.
    33. Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA. Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry. 2013 May 10; 19(20):6398-408. PMID: 23526661; PMCID: PMC3875175.
    34. Decourt B, Mobley W, Reiman E, Shah RJ, Sabbagh MN. Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome. J Alzheimers Dis Parkinsonism. 2013 Mar 20; Suppl 7:002. PMID: 24782952.
      View in: PubMed
    35. Zhang H, Petit GH, Gaughwin PM, Hansen C, Ranganathan S, Zuo X, Smith R, Roybon L, Brundin P, Mobley WC, Li JY. NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease. J Huntingtons Dis. 2013; 2(1):69-82. PMID: 25063430.
      View in: PubMed
    36. Ruparelia A, Pearn ML, Mobley WC. Aging and intellectual disability: insights from mouse models of Down syndrome. Dev Disabil Res Rev. 2013; 18(1):43-50. PMID: 23949828.
      View in: PubMed
    37. Wagner SL, Tanzi RE, Mobley WC, Galasko D. Potential use of ?-secretase modulators in the treatment of Alzheimer disease. Arch Neurol. 2012 Oct; 69(10):1255-8. PMID: 22801784; PMCID: PMC3747667.
    38. Kleschevnikov AM, Belichenko PV, Faizi M, Jacobs LF, Htun K, Shamloo M, Mobley WC. Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. J Neurosci. 2012 Jul 04; 32(27):9217-27. PMID: 22764230; PMCID: PMC3411326.
    39. Ruparelia A, Pearn ML, Mobley WC. Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. Curr Opin Neurobiol. 2012 Oct; 22(5):880-6. PMID: 22658745; PMCID: PMC3434300.
    40. Zhang L, Fu D, Belichenko PV, Liu C, Kleschevnikov AM, Pao A, Liang P, Clapcote SJ, Mobley WC, Yu YE. Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. Bioeng Bugs. 2012 Jan 01; 3(1):8-12. PMID: 22126738; PMCID: PMC3329253.
    41. Mobley W, N Rosenberg R. The evolution of academic neurology: new information will bring new meaning. Arch Neurol. 2012 Mar; 69(3):308-14. PMID: 22083800.
      View in: PubMed
    42. Kleschevnikov AM, Belichenko PV, Gall J, George L, Nosheny R, Maloney MT, Salehi A, Mobley WC. Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2012 Feb; 45(2):683-91. PMID: 22062771; PMCID: PMC3259223.
    43. Liu C, Belichenko PV, Zhang L, Fu D, Kleschevnikov AM, Baldini A, Antonarakis SE, Mobley WC, Yu YE. Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci. 2011; 33(5):404-13. PMID: 21865664; PMCID: PMC3254039.
    44. Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis EA. Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator. Org Lett. 2011 Sep 02; 13(17):4554-7. PMID: 21812392; PMCID: PMC3163030.
    45. Faizi M, Bader PL, Tun C, Encarnacion A, Kleschevnikov A, Belichenko P, Saw N, Priestley M, Tsien RW, Mobley WC, Shamloo M. Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of ß1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis. 2011 Aug; 43(2):397-413. PMID: 21527343; PMCID: PMC3539757.
    46. Rissman RA, Mobley WC. Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem. 2011 May; 117(4):613-22. PMID: 21388375; PMCID: PMC3127285.
    47. Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, Liu B, Baldini A, Mobley WC, Yu YE. Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res. 2010 Dec 17; 1366:162-71. PMID: 20932954; PMCID: PMC3027718.
    48. Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 09; 67(5):769-80. PMID: 20826309; PMCID: PMC2947312.
    49. Yu T, Clapcote SJ, Li Z, Liu C, Pao A, Bechard AR, Carattini-Rivera S, Matsui S, Roder JC, Baldini A, Mobley WC, Bradley A, Yu YE. Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mamm Genome. 2010 Jun; 21(5-6):258-67. PMID: 20512340; PMCID: PMC3023176.
    50. Tamaki SJ, Jacobs Y, Dohse M, Capela A, Cooper JD, Reitsma M, He D, Tushinski R, Belichenko PV, Salehi A, Mobley W, Gage FH, Huhn S, Tsukamoto AS, Weissman IL, Uchida N. Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 2009 Sep 04; 5(3):310-9. PMID: 19733542.
      View in: PubMed
    51. Mégarbané A, Ravel A, Mircher C, Sturtz F, Grattau Y, Rethoré MO, Delabar JM, Mobley WC. The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome. Genet Med. 2009 Sep; 11(9):611-6. PMID: 19636252.
      View in: PubMed
    52. Belichenko PV, Wright EE, Belichenko NP, Masliah E, Li HH, Mobley WC, Francke U. Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. J Comp Neurol. 2009 May 20; 514(3):240-58. PMID: 19296534.
      View in: PubMed
    53. Belichenko NP, Belichenko PV, Kleschevnikov AM, Salehi A, Reeves RH, Mobley WC. The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci. 2009 May 06; 29(18):5938-48. PMID: 19420260; PMCID: PMC3849469.
    54. Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC. Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. J Comp Neurol. 2009 Feb 01; 512(4):453-66. PMID: 19034952.
      View in: PubMed
    55. Belichenko NP, Belichenko PV, Mobley WC. Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation. Neurobiol Dis. 2009 Apr; 34(1):71-7. PMID: 19167498.
      View in: PubMed
    56. Wu C, Cui B, He L, Chen L, Mobley WC. The coming of age of axonal neurotrophin signaling endosomes. J Proteomics. 2009 Feb 15; 72(1):46-55. PMID: 19028611; PMCID: PMC2677075.
    57. Wan J, Cheung AY, Fu WY, Wu C, Zhang M, Mobley WC, Cheung ZH, Ip NY. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. J Neurosci. 2008 Sep 03; 28(36):9002-12. PMID: 18768694.
      View in: PubMed
    58. Belichenko NP, Belichenko PV, Li HH, Mobley WC, Francke U. Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. J Comp Neurol. 2008 May 01; 508(1):184-95. PMID: 18306326.
      View in: PubMed
    59. Eaton DL, Daroff RB, Autrup H, Bridges J, Buffler P, Costa LG, Coyle J, McKhann G, Mobley WC, Nadel L, Neubert D, Schulte-Hermann R, Spencer PS. Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit Rev Toxicol. 2008; 38 Suppl 2:1-125. PMID: 18726789.
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    60. Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ. Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. Traffic. 2008 Feb; 9(2):215-29. PMID: 18034774; PMCID: PMC3810297.
    61. Belichenko PV, Kleschevnikov AM, Salehi A, Epstein CJ, Mobley WC. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol. 2007 Oct 01; 504(4):329-45. PMID: 17663443.
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    62. Wu C, Ramirez A, Cui B, Ding J, Delcroix JD, Valletta JS, Liu JJ, Yang Y, Chu S, Mobley WC. A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Traffic. 2007 Nov; 8(11):1503-20. PMID: 17822405.
      View in: PubMed
    63. Cui B, Wu C, Chen L, Ramirez A, Bearer EL, Li WP, Mobley WC, Chu S. One at a time, live tracking of NGF axonal transport using quantum dots. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13666-71. PMID: 17698956; PMCID: PMC1959439.
    64. Colas D, Valletta JS, Takimoto-Kimura R, Nishino S, Fujiki N, Mobley WC, Mignot E. Sleep and EEG features in genetic models of Down syndrome. Neurobiol Dis. 2008 Apr; 30(1):1-7. PMID: 18282758; PMCID: PMC4689324.
    65. Liu JJ, Ding J, Wu C, Bhagavatula P, Cui B, Chu S, Mobley WC, Yang Y. Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2223-8. PMID: 17287360; PMCID: PMC1892971.
    66. Salehi A, Faizi M, Belichenko PV, Mobley WC. Using mouse models to explore genotype-phenotype relationship in Down syndrome. Ment Retard Dev Disabil Res Rev. 2007; 13(3):207-14. PMID: 17910089.
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    67. Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42. PMID: 16815330.
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    68. Miyamoto Y, Yamauchi J, Tanoue A, Wu C, Mobley WC. TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10444-10449. PMID: 16801538.
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    69. Ding J, Allen E, Wang W, Valle A, Wu C, Nardine T, Cui B, Yi J, Taylor A, Jeon NL, Chu S, So Y, Vogel H, Tolwani R, Mobley W, Yang Y. Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. Hum Mol Genet. 2006 May 01; 15(9):1451-63. PMID: 16565160.
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    70. Villar AJ, Belichenko PV, Gillespie AM, Kozy HM, Mobley WC, Epstein CJ. Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm Genome. 2005 Feb; 16(2):79-90. PMID: 15859352.
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    71. Howe CL, Mobley WC. Long-distance retrograde neurotrophic signaling. Curr Opin Neurobiol. 2005 Feb; 15(1):40-8. PMID: 15721743.
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    72. Belichenko PV, Masliah E, Kleschevnikov AM, Villar AJ, Epstein CJ, Salehi A, Mobley WC. Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. J Comp Neurol. 2004 Dec 13; 480(3):281-98. PMID: 15515178.
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