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    Martin Marsala

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentAnesthesiology
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-822-3805
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      Collapse Research 
      Collapse Research Activities and Funding
      Modulation of spinal neurodegenerative diseases in swine by stem cell grafting
      NIH R01OD018272Jul 1, 2015 - Apr 30, 2019
      Role: Principal Investigator
      Transgenic mice and bioinformatic tools to track astrocyte diversification insitu
      NIH/NIMH R01MH099571Jan 1, 2013 - Dec 31, 2016
      Role: Principal Investigator
      Ischemic Spasticity: Modulation by GAD65 Gene Delivery
      NIH/NINDS R01NS051644May 1, 2006 - Apr 30, 2011
      Role: Principal Investigator
      Ischemic Paraplegia: Modulation by Stem Cell Implant
      NIH/NINDS R01NS040386Dec 15, 2001 - Nov 30, 2005
      Role: Principal Investigator
      SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURY
      NIH/NINDS R01NS032794Sep 1, 1994 - Mar 31, 2003
      Role: Principal Investigator
      EXCITATORY AMINO ACIDS IN ISCHEMIC INDUCED PARAPLEGIA
      NIH/FIC F05TW004649Aug 31, 1992
      Role: Principal Investigator
      Disease mechanism in ALS and frontotemporal dementia
      NIH/NINDS R01NS027036Apr 1, 1989 - Aug 31, 2022
      Role: Co-Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Tadokoro T, Miyanohara A, Navarro M, Kamizato K, Juhas S, Juhasova J, Marsala S, Platoshyn O, Curtis E, Gabel B, Ciacci J, Lukacova N, Bimbova K, Marsala M. Subpial Adeno-associated Virus 9 (AAV9) Vector Delivery in Adult Mice. J Vis Exp. 2017 Jul 13; (125). PMID: 28745630.
        View in: PubMed
      2. Gross ET, Han S, Vemu P, Peinado CD, Marsala M, Ellies LG, Bui JD. Immunosurveillance and immunoediting in MMTV-PyMT-induced mammary oncogenesis. Oncoimmunology. 2017; 6(2):e1268310. PMID: 28344881.
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      3. Gabel BC, Curtis EI, Marsala M, Ciacci JD. A review of stem cell therapy for spinal cord injury: large animal models and the frontier in humans. World Neurosurg. 2016 Nov 19. PMID: 27876663.
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      4. Varun D, Rajaram Srinivasan G, Tsai YH, Kim HJ, Cutts J, Petty F, Merkley R, Stephanopoulos N, Dolezalova D, Marsala M, Brafman DA. A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs). Acta Biomater. 2016 Oct 27. PMID: 27989923.
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      5. Curtis E, Gabel BC, Marsala M, Ciacci JD. 172 A Phase I, Open-Label, Single-Site, Safety Study of Human Spinal Cord-Derived Neural Stem Cell Transplantation for the Treatment of Chronic Spinal Cord Injury. Neurosurgery. 2016 Aug; 63 Suppl 1:168-9. PMID: 27399451.
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      6. Miyanohara A, Kamizato K, Juhas S, Juhasova J, Navarro M, Marsala S, Lukacova N, Hruska-Plochan M, Curtis E, Gabel B, Ciacci J, Ahrens ET, Kaspar BK, Cleveland D, Marsala M. Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. Mol Ther Methods Clin Dev. 2016; 3:16046. PMID: 27462649.
        View in: PubMed
      7. Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 2016 May 4; 90(3):535-50. PMID: 27112497.
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      8. Bravo-Hernández M, Corleto JA, Barragán-Iglesias P, González-Ramírez R, Pineda-Farias JB, Felix R, Calcutt NA, Delgado-Lezama R, Marsala M, Granados-Soto V. The a5 subunit containing GABAA receptors contribute to chronic pain. Pain. 2016 Mar; 157(3):613-26. PMID: 26545088.
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      9. Corleto JA, Bravo-Hernández M, Kamizato K, Kakinohana O, Santucci C, Navarro MR, Platoshyn O, Cizkova D, Lukacova N, Taylor J, Marsala M. Thoracic 9 Spinal Transection-Induced Model of Muscle Spasticity in the Rat: A Systematic Electrophysiological and Histopathological Characterization. PLoS One. 2015; 10(12):e0144642. PMID: 26713446.
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      10. Tyleckova J, Valekova I, Zizkova M, Rakocyova M, Marsala S, Marsala M, Gadher SJ, Kovarova H. Surface N-glycoproteome patterns reveal key proteins of neuronal differentiation. J Proteomics. 2016 Jan 30; 132:13-20. PMID: 26581640.
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      11. Liu WC, Kohn J, Szwed SK, Pariser E, Sepe S, Haripal B, Oshimori N, Marsala M, Miyanohara A, Lee R. Human mutant huntingtin disrupts vocal learning in transgenic songbirds. Nat Neurosci. 2015 Nov; 18(11):1617-22. PMID: 26436900.
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      12. Kwon BK, Streijger F, Hill CE, Anderson AJ, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, Houle JD, Jakeman LB, Jeffery ND, Jones LA, Kleitman N, Kocsis J, Lu P, Magnuson DS, Marsala M, Moore SW, Mothe AJ, Oudega M, Plant GW, Rabchevsky AS, Schwab JM, Silver J, Steward O, Xu XM, Guest JD, Tetzlaff W. Large animal and primate models of spinal cord injury for the testing of novel therapies. Exp Neurol. 2015 Jul; 269:154-68. PMID: 25902036.
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      13. Israelson A, Ditsworth D, Sun S, Song S, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, Maldonado M, Bui A, Navarro M, Zhou H, Marsala M, Kaspar BK, Da Cruz S, Cleveland DW. Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1. Neuron. 2015 Apr 8; 86(1):218-32. PMID: 25801706.
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      14. Zizkova M, Sucha R, Tyleckova J, Jarkovska K, Mairychova K, Kotrcova E, Marsala M, Gadher SJ, Kovarova H. Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies. Expert Rev Proteomics. 2015 Feb; 12(1):83-95. PMID: 25363140.
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      15. Tuszynski MH, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. Neural stem cells in models of spinal cord injury. Exp Neurol. 2014 Nov; 261:494-500. PMID: 25079369.
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      16. van Gorp S, Deumens R, Leerink M, Nguyen S, Joosten EA, Marsala M. Translation of the rat thoracic contusion model; part 1-supraspinally versus spinally mediated pain-like responses and spasticity. Spinal Cord. 2014 Jul; 52(7):524-8. PMID: 24819511.
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      17. van Gorp S, Leerink M, Nguyen S, Platoshyn O, Marsala M, Joosten EA. Translation of the rat thoracic contusion model; part 2 - forward versus backward locomotion testing. Spinal Cord. 2014 Jul; 52(7):529-35. PMID: 24819507.
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      18. Dolezalova D, Hruska-Plochan M, Bjarkam CR, Sørensen JC, Cunningham M, Weingarten D, Ciacci JD, Juhas S, Juhasova J, Motlik J, Hefferan MP, Hazel T, Johe K, Carromeu C, Muotri A, Bui J, Strnadel J, Marsala M. Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies. J Comp Neurol. 2014 Aug 15; 522(12):2784-801. PMID: 24610493.
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      19. Tuszynski MH, Wang Y, Graham L, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. Neural stem cell dissemination after grafting to CNS injury sites. Cell. 2014 Jan 30; 156(3):388-9. PMID: 24485445.
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      20. Kupcova Skalnikova H, Navarro R, Marsala S, Hrabakova R, Vodicka P, Gadher SJ, Kovarova H, Marsala M. Signaling proteins in spinal parenchyma and dorsal root ganglion in rat with spinal injury-induced spasticity. J Proteomics. 2013 Oct 8; 91:41-57. PMID: 23835433.
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      21. Sevc J, Goldberg D, van Gorp S, Leerink M, Juhas S, Juhasova J, Marsala S, Hruska-Plochan M, Hefferan MP, Motlik J, Rypacek F, Machova L, Kakinohana O, Santucci C, Johe K, Lukacova N, Yamada K, Bui JD, Marsala M. Effective long-term immunosuppression in rats by subcutaneously implanted sustained-release tacrolimus pellet: effect on spinally grafted human neural precursor survival. Exp Neurol. 2013 Oct; 248:85-99. PMID: 23748136.
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      22. van Gorp S, Leerink M, Kakinohana O, Platoshyn O, Santucci C, Galik J, Joosten EA, Hruska-Plochan M, Goldberg D, Marsala S, Johe K, Ciacci JD, Marsala M. Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation. Stem Cell Res Ther. 2013; 4(3):57. PMID: 23710605.
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      23. Arnold ES, Ling SC, Huelga SC, Lagier-Tourenne C, Polymenidou M, Ditsworth D, Kordasiewicz HB, McAlonis-Downes M, Platoshyn O, Parone PA, Da Cruz S, Clutario KM, Swing D, Tessarollo L, Marsala M, Shaw CE, Yeo GW, Cleveland DW. ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):E736-45. PMID: 23382207.
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      24. Baxa M, Hruska-Plochan M, Juhas S, Vodicka P, Pavlok A, Juhasova J, Miyanohara A, Nejime T, Klima J, Macakova M, Marsala S, Weiss A, Kubickova S, Musilova P, Vrtel R, Sontag EM, Thompson LM, Schier J, Hansikova H, Howland DS, Cattaneo E, DiFiglia M, Marsala M, Motlik J. A Transgenic Minipig Model of Huntington's Disease. J Huntingtons Dis. 2013 Jan; 2(1):47-68. PMID: 25063429.
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      25. Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Tuszynski MH. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012 Sep 14; 150(6):1264-73. PMID: 22980985.
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      26. Hefferan MP, Galik J, Kakinohana O, Sekerkova G, Santucci C, Marsala S, Navarro R, Hruska-Plochan M, Johe K, Feldman E, Cleveland DW, Marsala M. Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation. PLoS One. 2012; 7(8):e42614. PMID: 22916141.
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      27. Kakinohana O, Juhasova J, Juhas S, Motlik J, Platoshyn O, Galik J, Hefferan M, Yuan SH, Vidal JG, Carson CT, van Gorp S, Goldberg D, Leerink M, Lazar P, Marsala S, Miyanohara A, Keshavarzi S, Ciacci JD, Marsala M. Survival and differentiation of human embryonic stem cell-derived neural precursors grafted spinally in spinal ischemia-injured rats or in naive immunosuppressed minipigs: a qualitative and quantitative study. Cell Transplant. 2012; 21(12):2603-19. PMID: 22889456.
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      28. Kakinohana O, Scadeng M, Corleto JA, Sevc J, Lukacova N, Marsala M. Development of AMPA receptor and GABA B receptor-sensitive spinal hyper-reflexia after spinal air embolism in rat: a systematic neurological, electrophysiological and qualitative histopathological study. Exp Neurol. 2012 Sep; 237(1):26-35. PMID: 22721766.
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      29. Da Cruz S, Parone PA, Lopes VS, Lillo C, McAlonis-Downes M, Lee SK, Vetto AP, Petrosyan S, Marsala M, Murphy AN, Williams DS, Spiegelman BM, Cleveland DW. Elevated PGC-1a activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab. 2012 May 2; 15(5):778-86. PMID: 22560226.
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      30. Xu Q, Chou B, Fitzsimmons B, Miyanohara A, Shubayev V, Santucci C, Hefferan M, Marsala M, Hua XY. In vivo gene knockdown in rat dorsal root ganglia mediated by self-complementary adeno-associated virus serotype 5 following intrathecal delivery. PLoS One. 2012; 7(3):e32581. PMID: 22403675.
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      31. Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Feb 9; 482(7384):216-20. PMID: 22278060.
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      32. Kakinohana O, Hefferan MP, Miyanohara A, Nejime T, Marsala S, Juhas S, Juhasova J, Motlik J, Kucharova K, Strnadel J, Platoshyn O, Lazar P, Galik J, Vinay L, Marsala M. Combinational spinal GAD65 gene delivery and systemic GABA-mimetic treatment for modulation of spasticity. PLoS One. 2012; 7(1):e30561. PMID: 22291989.
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      33. Navarro R, Juhas S, Keshavarzi S, Juhasova J, Motlik J, Johe K, Marsala S, Scadeng M, Lazar P, Tomori Z, Schulteis G, Beattie M, Ciacci JD, Marsala M. Chronic spinal compression model in minipigs: a systematic behavioral, qualitative, and quantitative neuropathological study. J Neurotrauma. 2012 Feb 10; 29(3):499-513. PMID: 22029501.
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      34. Hefferan MP, Johe K, Hazel T, Feldman EL, Lunn JS, Marsala M. Optimization of immunosuppressive therapy for spinal grafting of human spinal stem cells in a rat model of ALS. Cell Transplant. 2011; 20(8):1153-61. PMID: 21669047.
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      35. Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein LS, Carson CT. Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One. 2011; 6(3):e17540. PMID: 21407814.
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      36. Oshiro M, Hefferan MP, Kakinohana O, Lukacova N, Sugahara K, Yaksh TL, Marsala M. Suppression of stretch reflex activity after spinal or systemic treatment with AMPA receptor antagonist NGX424 in rats with developed baclofen tolerance. Br J Pharmacol. 2010 Nov; 161(5):976-85. PMID: 20977450.
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      37. Lunn JS, Pacut C, Backus C, Hong Y, Johe K, Hefferan M, Marsala M, Feldman EL. The pleotrophic effects of insulin-like growth factor-I on human spinal cord neural progenitor cells. Stem Cells Dev. 2010 Dec; 19(12):1983-93. PMID: 20406098.
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      38. Emre N, Vidal JG, Elia J, O'Connor ED, Paramban RI, Hefferan MP, Navarro R, Goldberg DS, Varki NM, Marsala M, Carson CT. The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers. PLoS One. 2010; 5(8):e12148. PMID: 20730054.
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      39. Usvald D, Vodicka P, Hlucilova J, Prochazka R, Motlik J, Kuchorova K, Johe K, Marsala S, Scadeng M, Kakinohana O, Navarro R, Santa M, Hefferan MP, Yaksh TL, Marsala M. Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs. Cell Transplant. 2010; 19(9):1103-22. PMID: 20412634.
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      40. Boulenguez P, Liabeuf S, Bos R, Bras H, Jean-Xavier C, Brocard C, Stil A, Darbon P, Cattaert D, Delpire E, Marsala M, Vinay L. Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury. Nat Med. 2010 Mar; 16(3):302-7. PMID: 20190766.
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      41. Marchetto MC, Yeo GW, Kainohana O, Marsala M, Gage FH, Muotri AR. Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One. 2009; 4(9):e7076. PMID: 19763270.
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      42. Lunn JS, Hefferan MP, Marsala M, Feldman EL. Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery. Growth Factors. 2009 Jun; 27(3):133-40. PMID: 19294549.
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      43. Codeluppi S, Svensson CI, Hefferan MP, Valencia F, Silldorff MD, Oshiro M, Marsala M, Pasquale EB. The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord. J Neurosci. 2009 Jan 28; 29(4):1093-104. PMID: 19176818.
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      44. Ilieva HS, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW. Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12599-604. PMID: 18719118.
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      45. Kim DH, Fitzsimmons B, Hefferan MP, Svensson CI, Wancewicz E, Monia BP, Hung G, Butler M, Marsala M, Hua XY, Yaksh TL. Inhibition of spinal cytosolic phospholipase A(2) expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia. Neuroscience. 2008 Jun 26; 154(3):1077-87. PMID: 18511207.
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      46. Lukacova N, Davidova A, Kolesar D, Kolesarova M, Schreiberova A, Lackova M, Krizanova O, Marsala M, Marsala J. The effect of N-nitro-L-arginine and aminoguanidine treatment on changes in constitutive and inducible nitric oxide synthases in the spinal cord after sciatic nerve transection. Int J Mol Med. 2008 Apr; 21(4):413-21. PMID: 18360686.
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      47. Hefferan MP, Kucharova K, Kinjo K, Kakinohana O, Sekerkova G, Nakamura S, Fuchigami T, Tomori Z, Yaksh TL, Kurtz N, Marsala M. Spinal astrocyte glutamate receptor 1 overexpression after ischemic insult facilitates behavioral signs of spasticity and rigidity. J Neurosci. 2007 Oct 17; 27(42):11179-91. PMID: 17942713.
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      48. Hedlund E, Hefferan MP, Marsala M, Isacson O. Cell therapy and stem cells in animal models of motor neuron disorders. Eur J Neurosci. 2007 Oct; 26(7):1721-37. PMID: 17897390.
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      49. Kakinohana M, Oshiro M, Saikawa S, Nakamura S, Higa T, Davison KJ, Marsala M, Sugahara K. Intravenous infusion of dexmedetomidine can prevent the degeneration of spinal ventral neurons induced by intrathecal morphine after a noninjurious interval of spinal cord ischemia in rats. Anesth Analg. 2007 Oct; 105(4):1086-93, table of contents. PMID: 17898393.
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      50. Kozak I, Bron AJ, Kucharova K, Kluchova D, Marsala M, Heichel CW, Tiffany JM. Morphologic and volumetric studies of the meibomian glands in elderly human eyelids. Cornea. 2007 Jun; 26(5):610-4. PMID: 17525661.
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      51. Marsala J, Lukácová N, Kolesár D, Sulla I, Gálik J, Marsala M. The distribution of primary nitric oxide synthase- and parvalbumin- immunoreactive afferents in the dorsal funiculus of the lumbosacral spinal cord in a dog. Cell Mol Neurobiol. 2007 Jun; 27(4):475-504. PMID: 17387607.
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      52. Jones TL, Hefferan MP, Marsala M, Sorkin LS. Low-speed subcellular fractionation method for determining noxious stimulus-evoked spinal neurokinin-1 receptor internalization. J Neurosci Methods. 2007 Mar 30; 161(1):23-31. PMID: 17083983.
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      53. Marsala J, Lukácová N, Kolesár D, Kuchárová K, Marsala M. Nitrergic proprioceptive afferents originating from quadriceps femoris muscle are related to monosynaptic Ia-motoneuron stretch reflex circuit in the dog. Cell Mol Neurobiol. 2006 Oct-Nov; 26(7-8):1387-412. PMID: 16724275.
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      54. Kakinohana O, Hefferan MP, Nakamura S, Kakinohana M, Galik J, Tomori Z, Marsala J, Yaksh TL, Marsala M. Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study. Neuroscience. 2006 Sep 1; 141(3):1569-83. PMID: 16797137.
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      55. Lukácová N, Kolesárová M, Kuchárová K, Pavel J, Kolesár D, Radonák J, Marsala M, Chalimoniuk M, Langfort J, Marsala J. The effect of a spinal cord hemisection on changes in nitric oxide synthase pools in the site of injury and in regions located far away from the injured site. Cell Mol Neurobiol. 2006 Oct-Nov; 26(7-8):1367-85. PMID: 16786429.
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      56. Kucharova K, Lukacova N, Pavel J, Radonak J, Hefferan MP, Kolesar D, Kolesarova M, Marsala M, Marsala J. Spatiotemporal alterations of the NO/NOS neuronal pools following transient abdominal aorta occlusion: morphological and biochemical studies in the rabbit. Cell Mol Neurobiol. 2006 Oct-Nov; 26(7-8):1295-310. PMID: 16786431.
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      57. Hefferan MP, Fuchigami T, Marsala M. Development of baclofen tolerance in a rat model of chronic spasticity and rigidity. Neurosci Lett. 2006 Jul 31; 403(1-2):195-200. PMID: 16716507.
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      58. Lukácová N, Kolesár D, Marsala M, Marsala J. Immunohistochemical, histochemical and radioassay analysis of nitric oxide synthase immunoreactivity in the lumbar and sacral dorsal root ganglia of the dog. Cell Mol Neurobiol. 2006 Feb; 26(1):17-44. PMID: 16633899.
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      59. Marsala M, Hefferan MP, Kakinohana O, Nakamura S, Marsala J, Tomori Z. Measurement of peripheral muscle resistance in rats with chronic ischemia-induced paraplegia or morphine-induced rigidity using a semi-automated computer-controlled muscle resistance meter. J Neurotrauma. 2005 Nov; 22(11):1348-61. PMID: 16305323.
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      60. Marsala J, Lukácová N, Sulla I, Wohlfahrt P, Marsala M. The evidence for nitric oxide synthase immunopositivity in the monosynaptic Ia-motoneuron pathway of the dog. Exp Neurol. 2005 Sep; 195(1):161-78. PMID: 15979072.
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      61. Kakinohana M, Kakinohana O, Jun JH, Marsala M, Davison KJ, Sugahara K. The activation of spinal N-methyl-D-aspartate receptors may contribute to degeneration of spinal motor neurons induced by neuraxial morphine after a noninjurious interval of spinal cord ischemia. Anesth Analg. 2005 Feb; 100(2):327-34. PMID: 15673851.
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      62. Marsala M, Kakinohana O, Hefferan MP, Cizkova D, Kinjoh K, Marsala S. Synaptogenesis and amino acid release from long term embryonic rat spinal cord neuronal culture using tissue culture inserts. J Neurosci Methods. 2005 Jan 30; 141(1):21-7. PMID: 15585285.
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      63. Marsala M, Kakinohana O, Yaksh TL, Tomori Z, Marsala S, Cizkova D. Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia. Eur J Neurosci. 2004 Nov; 20(9):2401-14. PMID: 15525281.
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      64. Kakinohana O, Cizkova D, Tomori Z, Hedlund E, Marsala S, Isacson O, Marsala M. Region-specific cell grafting into cervical and lumbar spinal cord in rat: a qualitative and quantitative stereological study. Exp Neurol. 2004 Nov; 190(1):122-32. PMID: 15473986.
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      65. Marsala J, Lukácová N, Cízková D, Lukác I, Kuchárová K, Marsala M. Premotor nitric oxide synthase immunoreactive pathway connecting lumbar segments with the ventral motor nucleus of the cervical enlargement in the dog. J Chem Neuroanat. 2004 Mar; 27(1):43-54. PMID: 15036362.
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      66. Lukácová N, Kafka J, Cízková D, Marsala M, Marsala J. The effect of cauda equina constriction on nitric oxide synthase activity. Neurochem Res. 2004 Feb; 29(2):429-39. PMID: 15002741.
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      67. Sasara T, Cizkova D, Mestril R, Galik J, Sugahara K, Marsala M. Spinal heat shock protein (70) expression: effect of spinal ischemia, hyperthermia (42 degrees C)/hypothermia (27 degrees C), NMDA receptor activation and potassium evoked depolarization on the induction. Neurochem Int. 2004 Jan; 44(1):53-64. PMID: 12963088.
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      68. Marsala M. Loop dialysis catheter: a technology for chronic spinal dialysis in a freely moving rat. Methods Mol Med. 2004; 99:99-108. PMID: 15131332.
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      69. Carmel JB, Kakinohana O, Mestril R, Young W, Marsala M, Hart RP. Mediators of ischemic preconditioning identified by microarray analysis of rat spinal cord. Exp Neurol. 2004 Jan; 185(1):81-96. PMID: 14697320.
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      70. Cizkova D, Carmel JB, Yamamoto K, Kakinohana O, Sun D, Hart RP, Marsala M. Characterization of spinal HSP72 induction and development of ischemic tolerance after spinal ischemia in rats. Exp Neurol. 2004 Jan; 185(1):97-108. PMID: 14697321.
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      71. Tokumine J, Kakinohana O, Cizkova D, Smith DW, Marsala M. Changes in spinal GDNF, BDNF, and NT-3 expression after transient spinal cord ischemia in the rat. J Neurosci Res. 2003 Nov 15; 74(4):552-61. PMID: 14598299.
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      72. Nakai K, Takenobu Y, Takimizu H, Akimaru S, Ito H, Maegawa H, Marsala M, Katsube N. Effects of orally administered OP-1206 alpha-CD with loxoprofen-Na on walking dysfunction in the rat neuropathic intermittent claudication model. Prostaglandins Leukot Essent Fatty Acids. 2003 Oct; 69(4):269-73. PMID: 12907137.
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      73. Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003 Sep; 86(6):1534-44. PMID: 12950462.
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      74. Nakai K, Takenobu Y, Takimizu H, Akimaru S, Maegawa H, Ito H, Marsala M, Katsube N. Effects of OP-1206 alpha-CD on walking dysfunction in the rat neuropathic intermittent claudication model: comparison with nifedipine, ticlopidine and cilostazol. Prostaglandins Other Lipid Mediat. 2003 Jul; 71(3-4):253-63. PMID: 14518565.
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      75. Sorkin LS, Maruyama K, Boyle DL, Yang L, Marsala M, Firestein GS. Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis. Neurosci Lett. 2003 Apr 10; 340(2):119-22. PMID: 12668251.
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      76. Kakinohana M, Marsala M, Carter C, Davison JK, Yaksh TL. Neuraxial morphine may trigger transient motor dysfunction after a noninjurious interval of spinal cord ischemia: a clinical and experimental study. Anesthesiology. 2003 Apr; 98(4):862-70. PMID: 12657847.
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      77. Ibuki T, Marsala M, Masuyama T, Yaksh TL. Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats. Br J Pharmacol. 2003 Feb; 138(4):689-97. PMID: 12598423.
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      78. Marsala J, Marsala M, Lukácová N, Ishikawa T, Cízková D. Localization and distribution patterns of nicotinamide adenine dinucleotide phosphate diaphorase exhibiting axons in the white matter of the spinal cord of the rabbit. Cell Mol Neurobiol. 2003 Feb; 23(1):57-92. PMID: 12701884.
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      79. Lukácová N, Cízková D, Krizanová O, Pavel J, Marsala M, Marsala J. Peripheral axotomy affects nicotinamide adenine dinucleotide phosphate diaphorase and nitric oxide synthases in the spinal cord of the rabbit. J Neurosci Res. 2003 Jan 15; 71(2):300-13. PMID: 12503094.
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      80. Cizkova D, Marsala J, Lukacova N, Marsala M, Jergova S, Orendacova J, Yaksh TL. Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury. Exp Brain Res. 2002 Dec; 147(4):456-63. PMID: 12444477.
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      81. Marsala J, Lukácová N, Cizková D, Kafka J, Katsube N, Kuchárová K, Marsala M. The case for the bulbospinal respiratory nitric oxide synthase-immunoreactive pathway in the dog. Exp Neurol. 2002 Sep; 177(1):115-32. PMID: 12429216.
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      82. Nakai K, Takenobu Y, Eguchi K, Takimizu H, Honjo K, Akimaru S, Maegawa H, Marsala M, Katsube N. The effects of OP-1206 alpha-CD on walking dysfunction in the rat neuropathic intermittent claudication model. Anesth Analg. 2002 Jun; 94(6):1537-41, table of contents. PMID: 12032022.
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      83. Lukácová N, Cízková D, Marsala M, Lukác I, Marsala J. The regional distribution of nitric oxide synthase activity in the spinal cord of the dog. Brain Res Bull. 2002 Jun; 58(2):173-8. PMID: 12127014.
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      84. Cízková D, Lukácová N, Marsala M, Marsala J. Neuropathic pain is associated with alterations of nitric oxide synthase immunoreactivity and catalytic activity in dorsal root ganglia and spinal dorsal horn. Brain Res Bull. 2002 Jun; 58(2):161-71. PMID: 12127013.
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      85. Lin CR, Tai MH, Cheng JT, Chou AK, Wang JJ, Tan PH, Marsala M, Yang LC. Electroporation for direct spinal gene transfer in rats. Neurosci Lett. 2002 Jan 4; 317(1):1-4. PMID: 11750982.
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      86. Ishikawa T, Marsala M, Sakabe T, Yaksh TL. Characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABA(A) receptor antagonist. Neuroscience. 2000; 95(3):781-6. PMID: 10670445.
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      87. Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, Marsala M. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc Natl Acad Sci U S A. 1999 Jul 6; 96(14):7680-6. PMID: 10393880.
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      88. Hua XY, Chen P, Marsala M, Yaksh TL. Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids. Neuroscience. 1999 Mar; 89(2):525-34. PMID: 10077333.
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      89. Kakinohana M, Taira Y, Marsala M. The effect of graded postischemic spinal cord hypothermia on neurological outcome and histopathology after transient spinal ischemia in rat. Anesthesiology. 1999 Mar; 90(3):789-98. PMID: 10078681.
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      90. Buerkle H, Marsala M, Yaksh TL. Effect of continuous spinal remifentanil infusion on behaviour and spinal glutamate release evoked by subcutaneous formalin in the rat. Br J Anaesth. 1998 Mar; 80(3):348-53. PMID: 9623437.
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      91. Hua XY, Chen P, Polgar E, Nagy I, Marsala M, Phillips E, Wollaston L, Urban L, Yaksh TL, Webb M. Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy. J Neurochem. 1998 Feb; 70(2):688-98. PMID: 9453563.
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      92. Marsala M, Galik J, Ishikawa T, Yaksh TL. Technique of selective spinal cord cooling in rat: methodology and application. J Neurosci Methods. 1997 Jun 6; 74(1):97-106. PMID: 9210579.
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      93. Khan IM, Marsala M, Printz MP, Taylor P, Yaksh TL. Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats. J Pharmacol Exp Ther. 1996 Jul; 278(1):97-106. PMID: 8764340.
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      94. Jhamandas KH, Marsala M, Ibuki T, Yaksh TL. Spinal amino acid release and precipitated withdrawal in rats chronically infused with spinal morphine. J Neurosci. 1996 Apr 15; 16(8):2758-66. PMID: 8786451.
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      95. Marsala M, Malmberg AB, Yaksh TL. The spinal loop dialysis catheter: characterization of use in the unanesthetized rat. J Neurosci Methods. 1995 Nov; 62(1-2):43-53. PMID: 8750084.
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      96. Abram SE, Marsala M, Yaksh TL. Analgesic and neurotoxic effects of intrathecal corticosteroids in rats. Anesthesiology. 1994 Nov; 81(5):1198-205. PMID: 7978478.
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      97. Marsala M, Vanicky I, Yaksh TL. Effect of graded hypothermia (27 degrees to 34 degrees C) on behavioral function, histopathology, and spinal blood flow after spinal ischemia in rat. Stroke. 1994 Oct; 25(10):2038-46. PMID: 8091450.
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