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An infrastructure for qualified data sharing and team science in late-stage translational spinal cord injury research. Exp Neurol. 2024 Oct 09; 114995.
Huie JR, Torres-Espin A, Sacramento J, Keller AV, Joiner WM, North R, Reinkensmeyer DJ, Rosenzweig ES, Koffler J, Tuszynski MH, Sparrey CJ, Nielson JL, Bresnahan JC, Grethe JS, Ferguson AR. PMID: 39393672.
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PubMed Mentions: Fields:
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A facilitatory role of astrocytes in axonal regeneration after acute and chronic spinal cord injury. Exp Neurol. 2024 Sep; 379:114889.
Lu P, Graham L, Tran AN, Villarta A, Koffler J, Tuszynski MH. PMID: 39019303.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Disruption of Core Stress Granule Protein Aggregates Promotes CNS Axon Regeneration. bioRxiv. 2024 Jun 08.
Sahoo PK, Hanovice N, Ward P, Agrawal M, Smith TP, SiMa H, Dulin JN, Vaughn LS, Tuszynski M, Welshhans K, Benowitz L, English A, Houle JD, Twiss JL. PMID: 38895344; PMCID: PMC11185597.
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PubMed Mentions:
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An improved method for generating human spinal cord neural stem cells. Exp Neurol. 2024 Jun; 376:114779.
Li Y, Kumamaru H, Vokes TJ, Tran AN, Shevinsky CA, Graham L, Archuleta K, Limon KR, Lu P, Blesch A, Tuszynski MH, Brock JH. PMID: 38621449.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Selective plasticity of layer 2/3 inputs onto distal forelimb controlling layer 5 corticospinal neurons with skilled grasp motor training. Cell Rep. 2024 Apr 23; 43(4):113986.
Takashima Y, Biane JS, Tuszynski MH. PMID: 38598336.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Growth Factor Gene Therapy for Alzheimer's Disease. J Alzheimers Dis. 2024; 101(s1):S433-S441.
Tuszynski MH. PMID: 39422960.
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Translation:
HumansAnimals
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Emergence of functionally aberrant and subsequent reduction of neuromuscular connectivity and improved motor performance after cervical spinal cord injury in Rhesus. Front Rehabil Sci. 2023; 4:1205456.
Wai G, Zdunowski S, Zhong H, Nielson JL, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Nout-Lomas YS, Rosenzweig ES, Beattie MS, Bresnahan JC, Tuszynski MH, Roy RR, Edgerton VR. PMID: 37378049; PMCID: PMC10291623.
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PubMed Mentions:
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Regulation of axonal regeneration after mammalian spinal cord injury. Nat Rev Mol Cell Biol. 2023 06; 24(6):396-413.
Zheng B, Tuszynski MH. PMID: 36604586.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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BDNF guides neural stem cell-derived axons to ventral interneurons and motor neurons after spinal cord injury. Exp Neurol. 2023 01; 359:114259.
Li Y, Tran A, Graham L, Brock J, Tuszynski MH, Lu P. PMID: 36309123.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Rehabilitation combined with neural progenitor cell grafts enables functional recovery in chronic spinal cord injury. JCI Insight. 2022 08 22; 7(16).
Lu P, Freria CM, Graham L, Tran AN, Villarta A, Yassin D, Huie JR, Ferguson AR, Tuszynski MH. PMID: 35993363; PMCID: PMC9462483.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Rhesus macaque versus rat divergence in the corticospinal projectome. Neuron. 2022 09 21; 110(18):2970-2983.e4.
Sinopoulou E, Rosenzweig ES, Conner JM, Gibbs D, Weinholtz CA, Weber JL, Brock JH, Nout-Lomas YS, Ovruchesky E, Takashima Y, Biane JS, Kumamaru H, Havton LA, Beattie MS, Bresnahan JC, Tuszynski MH. PMID: 35917818; PMCID: PMC9509478.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Methods for culturing adult CNS neurons reveal a CNS conditioning effect. Cell Rep Methods. 2022 07 18; 2(7):100255.
van Niekerk EA, Kawaguchi R, Marques de Freria C, Groeniger K, Marchetto MC, Dupraz S, Bradke F, Geschwind DH, Gage FH, Tuszynski MH. PMID: 35880023; PMCID: PMC9308166.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Quantifying the kinematic features of dexterous finger movements in nonhuman primates with markerless tracking. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:6110-6115.
North R, Wurr R, Macon R, Mannion C, Hyde J, Torres-Espin A, Rosenzweig ES, Ferguson AR, Tuszynski MH, Beattie MS, Bresnahan JC, Joiner WM. PMID: 34892511.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Optic Nerve Engraftment of Neural Stem Cells. Invest Ophthalmol Vis Sci. 2021 07 01; 62(9):30.
Do JL, Allahwerdy S, David RCC, Weinreb RN, Tuszynski MH, Welsbie DS. PMID: 34283208; PMCID: PMC8300061.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Experimental Treatments for Spinal Cord Injury: What you Should Know. Top Spinal Cord Inj Rehabil. 2021 Spring; 27(2):50-74.
Failli V, Kleitman N, Lammertse DP, Hsieh JTC, Steeves JD, Fawcett JW, Tuszynski MH, Curt A, Fehlings MG, Guest JD, Blight AR. PMID: 34108834; PMCID: PMC8152172.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Regeneration of Corticospinal Axons into Neural Progenitor Cell Grafts After Spinal Cord Injury. Neurosci Insights. 2020; 15:2633105520974000.
Poplawski GH, Tuszynski MH. PMID: 33283187; PMCID: PMC7691939.
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PubMed Mentions:
1
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Sexual dimorphism of detrusor function demonstrated by urodynamic studies in rhesus macaques. Sci Rep. 2020 09 30; 10(1):16170.
Biscola NP, Christe KL, Rosenzweig ES, Tuszynski MH, Havton LA. PMID: 32999325; PMCID: PMC7527962.
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PubMed Mentions:
3 Fields:
Translation:
Animals
-
Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury. Cell Stem Cell. 2020 09 03; 27(3):430-440.e5.
Ceto S, Sekiguchi KJ, Takashima Y, Nimmerjahn A, Tuszynski MH. PMID: 32758426; PMCID: PMC7484050.
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PubMed Mentions:
68 Fields:
Translation:
HumansCells
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Injured adult neurons regress to an embryonic transcriptional growth state. Nature. 2020 05; 581(7806):77-82.
Poplawski GHD, Kawaguchi R, Van Niekerk E, Lu P, Mehta N, Canete P, Lie R, Dragatsis I, Meves JM, Zheng B, Coppola G, Tuszynski MH. PMID: 32376949.
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PubMed Mentions:
110 Fields:
Translation:
AnimalsCells
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Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery. Hum Gene Ther. 2020 04; 31(7-8):415-422.
Castle MJ, Baltanás FC, Kovacs I, Nagahara AH, Barba D, Tuszynski MH. PMID: 32126838; PMCID: PMC7194314.
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PubMed Mentions:
45 Fields:
Translation:
HumansCellsCTClinical Trials
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Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury. Nat Neurosci. 2019 08; 22(8):1269-1275.
Rosenzweig ES, Salegio EA, Liang JJ, Weber JL, Weinholtz CA, Brock JH, Moseanko R, Hawbecker S, Pender R, Cruzen CL, Iaci JF, Caggiano AO, Blight AR, Haenzi B, Huie JR, Havton LA, Nout-Lomas YS, Fawcett JW, Ferguson AR, Beattie MS, Bresnahan JC, Tuszynski MH. PMID: 31235933; PMCID: PMC6693679.
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PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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Origins of Neural Progenitor Cell-Derived Axons Projecting Caudally after Spinal Cord Injury. Stem Cell Reports. 2019 07 09; 13(1):105-114.
Lu P, Gomes-Leal W, Anil S, Dobkins G, Huie JR, Ferguson AR, Graham L, Tuszynski M. PMID: 31204300; PMCID: PMC6626851.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Reorganization of Recurrent Layer 5 Corticospinal Networks Following Adult Motor Training. J Neurosci. 2019 06 12; 39(24):4684-4693.
Biane JS, Takashima Y, Scanziani M, Conner JM, Tuszynski MH. PMID: 30948479; PMCID: PMC6561695.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Regenerating Corticospinal Axons Innervate Phenotypically Appropriate Neurons within Neural Stem Cell Grafts. Cell Rep. 2019 02 26; 26(9):2329-2339.e4.
Kumamaru H, Lu P, Rosenzweig ES, Kadoya K, Tuszynski MH. PMID: 30811984; PMCID: PMC6487864.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Astrocytes migrate from human neural stem cell grafts and functionally integrate into the injured rat spinal cord. Exp Neurol. 2019 04; 314:46-57.
Lien BV, Tuszynski MH, Lu P. PMID: 30653967.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Biomimetic 3D-printed scaffolds for spinal cord injury repair. Nat Med. 2019 02; 25(2):263-269.
Koffler J, Zhu W, Qu X, Platoshyn O, Dulin JN, Brock J, Graham L, Lu P, Sakamoto J, Marsala M, Chen S, Tuszynski MH. PMID: 30643285; PMCID: PMC6559945.
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PubMed Mentions:
203 Fields:
Translation:
HumansAnimalsCells
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Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion. Sci Adv. 2018 11; 4(11):eaau9859.
Castle MJ, Cheng Y, Asokan A, Tuszynski MH. PMID: 30443600; PMCID: PMC6235539.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Activation of Intrinsic Growth State Enhances Host Axonal Regeneration into Neural Progenitor Cell Grafts. Stem Cell Reports. 2018 10 09; 11(4):861-868.
Kumamaru H, Lu P, Rosenzweig ES, Tuszynski MH. PMID: 30197116; PMCID: PMC6178188.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Generation and post-injury integration of human spinal cord neural stem cells. Nat Methods. 2018 09; 15(9):723-731.
Kumamaru H, Kadoya K, Adler AF, Takashima Y, Graham L, Coppola G, Tuszynski MH. PMID: 30082899.
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PubMed Mentions:
79 Fields:
Translation:
HumansCells
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Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2018 07 01; 75(7):834-841.
Rafii MS, Tuszynski MH, Thomas RG, Barba D, Brewer JB, Rissman RA, Siffert J, Aisen PS, AAV2-NGF Study Team. PMID: 29582053; PMCID: PMC5885277.
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PubMed Mentions:
87 Fields:
Translation:
HumansCells
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Adult rat myelin enhances axonal outgrowth from neural stem cells. Sci Transl Med. 2018 05 23; 10(442).
Poplawski GHD, Lie R, Hunt M, Kumamaru H, Kawaguchi R, Lu P, Schäfer MKE, Woodruff G, Robinson J, Canete P, Dulin JN, Geoffroy CG, Menzel L, Zheng B, Coppola G, Tuszynski MH. PMID: 29794059; PMCID: PMC8377986.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Microstructure and in vivo characterization of multi-channel nerve guidance scaffolds. Biomed Mater. 2018 04 25; 13(4):044104.
Pawelec KM, Koffler J, Shahriari D, Galvan A, Tuszynski MH, Sakamoto J. PMID: 29411711.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates. Gene Ther. 2018 04; 25(2):104-114.
Nagahara AH, Wilson BR, Ivasyk I, Kovacs I, Rawalji S, Bringas JR, Pivirotto PJ, Sebastian WS, Samaranch L, Bankiewicz KS, Tuszynski MH. PMID: 29535375; PMCID: PMC5924461.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Rodent Neural Progenitor Cells Support Functional Recovery after Cervical Spinal Cord Contusion. J Neurotrauma. 2018 05 01; 35(9):1069-1078.
Brock JH, Graham L, Staufenberg E, Im S, Tuszynski MH. PMID: 29279015; PMCID: PMC5908429.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Restorative effects of human neural stem cell grafts on the primate spinal cord. Nat Med. 2018 05; 24(4):484-490.
Rosenzweig ES, Brock JH, Lu P, Kumamaru H, Salegio EA, Kadoya K, Weber JL, Liang JJ, Moseanko R, Hawbecker S, Huie JR, Havton LA, Nout-Lomas YS, Ferguson AR, Beattie MS, Bresnahan JC, Tuszynski MH. PMID: 29480894; PMCID: PMC5922761.
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PubMed Mentions:
163 Fields:
Translation:
HumansAnimalsCells
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Oriented Nanofibrous Polymer Scaffolds Containing Protein-Loaded Porous Silicon Generated by Spray Nebulization. Adv Mater. 2018 Mar; 30(12):e1706785.
Zuidema JM, Kumeria T, Kim D, Kang J, Wang J, Hollett G, Zhang X, Roberts DS, Chan N, Dowling C, Blanco-Suarez E, Allen NJ, Tuszynski MH, Sailor MJ. PMID: 29363828; PMCID: PMC6475500.
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PubMed Mentions:
14 Fields:
Translation:
Animals
-
Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts. Nat Commun. 2018 01 08; 9(1):84.
Dulin JN, Adler AF, Kumamaru H, Poplawski GHD, Lee-Kubli C, Strobl H, Gibbs D, Kadoya K, Fawcett JW, Lu P, Tuszynski MH. PMID: 29311559; PMCID: PMC5758751.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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Enhanced axonal transport: A novel form of "plasticity" after primate and rodent spinal cord injury. Exp Neurol. 2018 03; 301(Pt A):59-69.
Brock JH, Rosenzweig ES, Yang H, Tuszynski MH. PMID: 29277625; PMCID: PMC7291621.
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PubMed Mentions: Fields:
Translation:
Animals
-
Peripheral nerve growth within a hydrogel microchannel scaffold supported by a kink-resistant conduit. J Biomed Mater Res A. 2017 Dec; 105(12):3392-3399.
Shahriari D, Shibayama M, Lynam DA, Wolf KJ, Kubota G, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS. PMID: 28804998; PMCID: PMC6611669.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Prolonged human neural stem cell maturation supports recovery in injured rodent CNS. J Clin Invest. 2017 Sep 01; 127(9):3287-3299.
Lu P, Ceto S, Wang Y, Graham L, Wu D, Kumamaru H, Staufenberg E, Tuszynski MH. PMID: 28825600; PMCID: PMC5669577.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Myelination of axons emerging from neural progenitor grafts after spinal cord injury. Exp Neurol. 2017 10; 296:69-73.
Hunt M, Lu P, Tuszynski MH. PMID: 28698030.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury. Stem Cell Reports. 2017 06 06; 8(6):1525-1533.
Adler AF, Lee-Kubli C, Kumamaru H, Kadoya K, Tuszynski MH. PMID: 28479302; PMCID: PMC5469919.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
Introduction to neuroscience letters special issue: "Plasticity and regeneration after spinal cord injury". Neurosci Lett. 2017 06 23; 652:1-2.
Lu P, Tuszynski MH. PMID: 28432027.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Hierarchically Ordered Porous and High-Volume Polycaprolactone Microchannel Scaffolds Enhanced Axon Growth in Transected Spinal Cords. Tissue Eng Part A. 2017 05; 23(9-10):415-425.
Shahriari D, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS. PMID: 28107810; PMCID: PMC5444512.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Efficient Retrograde Neuronal Transduction Utilizing Self-complementary AAV1. Mol Ther. 2008 Feb; 16(2):296-301.
Hollis Ii ER, Kadoya K, Hirsch M, Samulski RJ, Tuszynski MH. PMID: 28178539.
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PubMed Mentions:
1 Fields:
-
BDNF gene delivery within and beyond templated agarose multi-channel guidance scaffolds enhances peripheral nerve regeneration. J Neural Eng. 2016 12; 13(6):066011.
Gao M, Lu P, Lynam D, Bednark B, Campana WM, Sakamoto J, Tuszynski M. PMID: 27762235.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
-
A shared neural ensemble links distinct contextual memories encoded close in time. Nature. 2016 06 02; 534(7605):115-8.
Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. PMID: 27251287; PMCID: PMC5063500.
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PubMed Mentions:
422 Fields:
Translation:
AnimalsCells
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Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration. Nat Med. 2016 05; 22(5):479-87.
Kadoya K, Lu P, Nguyen K, Lee-Kubli C, Kumamaru H, Yao L, Knackert J, Poplawski G, Dulin JN, Strobl H, Takashima Y, Biane J, Conner J, Zhang SC, Tuszynski MH. PMID: 27019328; PMCID: PMC4860037.
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PubMed Mentions:
176 Fields:
Translation:
HumansAnimalsCells
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Thalamocortical Projections onto Behaviorally Relevant Neurons Exhibit Plasticity during Adult Motor Learning. Neuron. 2016 Mar 16; 89(6):1173-1179.
Biane JS, Takashima Y, Scanziani M, Conner JM, Tuszynski MH. PMID: 26948893; PMCID: PMC4795975.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
Rehabilitation drives enhancement of neuronal structure in functionally relevant neuronal subsets. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2750-5.
Wang L, Conner JM, Nagahara AH, Tuszynski MH. PMID: 26903653; PMCID: PMC4790976.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. 2016 Mar 02; 89(5):956-70.
Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. PMID: 26898779; PMCID: PMC4790095.
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PubMed Mentions:
184 Fields:
Translation:
AnimalsCells
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Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury. Exp Neurol. 2016 Apr; 278:91-104.
Lee-Kubli CA, Ingves M, Henry KW, Shiao R, Collyer E, Tuszynski MH, Campana WM. PMID: 26808661.
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PubMed Mentions:
26 Fields:
Translation:
Animals
-
A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta). J Neurotrauma. 2016 Mar 01; 33(5):439-59.
Salegio EA, Bresnahan JC, Sparrey CJ, Camisa W, Fischer J, Leasure J, Buckley J, Nout-Lomas YS, Rosenzweig ES, Moseanko R, Strand S, Hawbecker S, Lemoy MJ, Haefeli J, Ma X, Nielson JL, Edgerton VR, Ferguson AR, Tuszynski MH, Beattie MS. PMID: 26788611; PMCID: PMC4799702.
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PubMed Mentions:
19 Fields:
Translation:
Animals
-
Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury. Mol Cell Proteomics. 2016 Feb; 15(2):394-408.
van Niekerk EA, Tuszynski MH, Lu P, Dulin JN. PMID: 26695766; PMCID: PMC4739663.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury. J Neurotrauma. 2016 06 15; 33(12):1103-14.
Brock JH, Graham L, Staufenberg E, Collyer E, Koffler J, Tuszynski MH. PMID: 26414795; PMCID: PMC4904236.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
Characterizing the degradation of alginate hydrogel for use in multilumen scaffolds for spinal cord repair. J Biomed Mater Res A. 2016 03; 104(3):611-619.
Shahriari D, Koffler J, Lynam DA, Tuszynski MH, Sakamoto JS. PMID: 26488452.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Transcriptomic Approaches to Neural Repair. J Neurosci. 2015 Oct 14; 35(41):13860-7.
Dulin JN, Antunes-Martins A, Chandran V, Costigan M, Lerch JK, Willis DE, Tuszynski MH. PMID: 26468186; PMCID: PMC4604224.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease. JAMA Neurol. 2015 Oct; 72(10):1139-47.
Tuszynski MH, Yang JH, Barba D, U HS, Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, Nagahara AH. PMID: 26302439; PMCID: PMC4944824.
View in:
PubMed Mentions:
133 Fields:
Translation:
HumansCellsCTClinical Trials
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Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates. Sci Transl Med. 2015 Aug 26; 7(302):302ra134.
Friedli L, Rosenzweig ES, Barraud Q, Schubert M, Dominici N, Awai L, Nielson JL, Musienko P, Nout-Lomas Y, Zhong H, Zdunowski S, Roy RR, Strand SC, van den Brand R, Havton LA, Beattie MS, Bresnahan JC, Bézard E, Bloch J, Edgerton VR, Ferguson AR, Curt A, Tuszynski MH, Courtine G. PMID: 26311729; PMCID: PMC5669362.
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PubMed Mentions:
84 Fields:
Translation:
HumansAnimals
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Motor cortex maturation is associated with reductions in recurrent connectivity among functional subpopulations and increases in intrinsic excitability. J Neurosci. 2015 Mar 18; 35(11):4719-28.
Biane JS, Scanziani M, Tuszynski MH, Conner JM. PMID: 25788688; PMCID: PMC4363396.
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PubMed Mentions:
18 Fields:
Translation:
Animals
-
Brain derived neurotrophic factor release from layer-by-layer coated agarose nerve guidance scaffolds. Acta Biomater. 2015 May; 18:128-31.
Lynam DA, Shahriari D, Wolf KJ, Angart PA, Koffler J, Tuszynski MH, Chan C, Walton P, Sakamoto J. PMID: 25712385.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Cholinergic systems are essential for late-stage maturation and refinement of motor cortical circuits. J Neurophysiol. 2015 Mar 01; 113(5):1585-97.
Ramanathan DS, Conner JM, Anilkumar AA, Tuszynski MH. PMID: 25505106; PMCID: PMC4346727.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury. Brain Res. 2015 Sep 04; 1619:124-38.
Nielson JL, Haefeli J, Salegio EA, Liu AW, Guandique CF, Stück ED, Hawbecker S, Moseanko R, Strand SC, Zdunowski S, Brock JH, Roy RR, Rosenzweig ES, Nout-Lomas YS, Courtine G, Havton LA, Steward O, Reggie Edgerton V, Tuszynski MH, Beattie MS, Bresnahan JC, Ferguson AR. PMID: 25451131; PMCID: PMC4418964.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
-
Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex. Front Cell Neurosci. 2014; 8:220.
Biane J, Conner JM, Tuszynski MH. PMID: 25147503; PMCID: PMC4124705.
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PubMed Mentions:
22
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Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury. Neuron. 2014 Aug 20; 83(4):789-96.
Lu P, Woodruff G, Wang Y, Graham L, Hunt M, Wu D, Boehle E, Ahmad R, Poplawski G, Brock J, Goldstein LS, Tuszynski MH. PMID: 25123310; PMCID: PMC4144679.
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PubMed Mentions:
173 Fields:
Translation:
HumansAnimalsCells
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Development of a database for translational spinal cord injury research. J Neurotrauma. 2014 Nov 01; 31(21):1789-99.
Nielson JL, Guandique CF, Liu AW, Burke DA, Lash AT, Moseanko R, Hawbecker S, Strand SC, Zdunowski S, Irvine KA, Brock JH, Nout-Lomas YS, Gensel JC, Anderson KD, Segal MR, Rosenzweig ES, Magnuson DS, Whittemore SR, McTigue DM, Popovich PG, Rabchevsky AG, Scheff SW, Steward O, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC, Ferguson AR. PMID: 25077610; PMCID: PMC4186058.
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PubMed Mentions:
28 Fields:
Translation:
Animals
-
Neural stem cells in models of spinal cord injury. Exp Neurol. 2014 Nov; 261:494-500.
Tuszynski MH, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. PMID: 25079369.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Promotion of survival and differentiation of neural stem cells with fibrin and growth factor cocktails after severe spinal cord injury. J Vis Exp. 2014 Jul 27; (89):e50641.
Lu P, Graham L, Wang Y, Wu D, Tuszynski M. PMID: 25145787; PMCID: PMC4435462.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Axonal growth and connectivity from neural stem cell grafts in models of spinal cord injury. Curr Opin Neurobiol. 2014 Aug; 27:103-9.
Lu P, Kadoya K, Tuszynski MH. PMID: 24709371.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Neural stem cell dissemination after grafting to CNS injury sites. Cell. 2014 Jan 30; 156(3):388-9.
Tuszynski MH, Wang Y, Graham L, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. PMID: 24485445.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
-
Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci. 2013 Sep 25; 33(39):15596-602.
Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo EH, Masliah E, Tuszynski MH. PMID: 24068826; PMCID: PMC3782628.
View in:
PubMed Mentions:
80 Fields:
Translation:
Animals
-
SnoN facilitates axonal regeneration after spinal cord injury. PLoS One. 2013; 8(8):e71906.
Do JL, Bonni A, Tuszynski MH. PMID: 23936531; PMCID: PMC3732222.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration. J Biol Chem. 2013 Sep 13; 288(37):26557-68.
Yoon C, Van Niekerk EA, Henry K, Ishikawa T, Orita S, Tuszynski MH, Campana WM. PMID: 23867460; PMCID: PMC3772203.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection. Biomaterials. 2013 Feb; 34(5):1529-36.
Gao M, Lu P, Bednark B, Lynam D, Conner JM, Sakamoto J, Tuszynski MH. PMID: 23182350; PMCID: PMC3518618.
View in:
PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
-
Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012 Sep 14; 150(6):1264-73.
Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Tuszynski MH. PMID: 22980985; PMCID: PMC3445432.
View in:
PubMed Mentions:
403 Fields:
Translation:
HumansAnimalsCells
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JNK3 perpetuates metabolic stress induced by Aβ peptides. Neuron. 2012 Sep 06; 75(5):824-37.
Yoon SO, Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski MH, Huang K. PMID: 22958823; PMCID: PMC3438522.
View in:
PubMed Mentions:
107 Fields:
Translation:
HumansAnimals
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Motor axonal regeneration after partial and complete spinal cord transection. J Neurosci. 2012 Jun 13; 32(24):8208-18.
Lu P, Blesch A, Graham L, Wang Y, Samara R, Banos K, Haringer V, Havton L, Weishaupt N, Bennett D, Fouad K, Tuszynski MH. PMID: 22699902; PMCID: PMC3407545.
View in:
PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
-
Concepts and methods for the study of axonal regeneration in the CNS. Neuron. 2012 Jun 07; 74(5):777-91.
Tuszynski MH, Steward O. PMID: 22681683; PMCID: PMC3387806.
View in:
PubMed Mentions:
138 Fields:
Translation:
HumansAnimalsCells
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Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury. Neurotherapeutics. 2012 Apr; 9(2):380-92.
Nout YS, Rosenzweig ES, Brock JH, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Courtine G, Ferguson AR, Edgerton VR, Beattie MS, Bresnahan JC, Tuszynski MH. PMID: 22427157; PMCID: PMC3337011.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansAnimals
-
Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey. Neurorehabil Neural Repair. 2012 Jul-Aug; 26(6):556-69.
Nout YS, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Zhong H, Rosenzweig ES, Brock JH, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC. PMID: 22331214; PMCID: PMC3468651.
View in:
PubMed Mentions:
19 Fields:
Translation:
Animals
-
Frontiers of spinal cord and spine repair: experimental approaches for repair of spinal cord injury. Adv Exp Med Biol. 2012; 760:1-15.
Yoon C, Tuszynski MH. PMID: 23281510.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
-
Gene therapy, neurotrophic factors and spinal cord regeneration. Handb Clin Neurol. 2012; 109:563-74.
Blesch A, Fischer I, Tuszynski MH. PMID: 23098737.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
-
Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: superiority to camp-mediated effects. Exp Neurol. 2012 May; 235(1):162-73.
Blesch A, Lu P, Tsukada S, Alto LT, Roet K, Coppola G, Geschwind D, Tuszynski MH. PMID: 22227059; PMCID: PMC3334479.
View in:
PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
-
Neurotrophins: potential therapeutic tools for the treatment of spinal cord injury. Neurotherapeutics. 2011 Oct; 8(4):694-703.
Hollis ER, Tuszynski MH. PMID: 21904786; PMCID: PMC3250295.
View in:
PubMed Mentions:
27 Fields:
Translation:
Humans
-
Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov. 2011 Mar; 10(3):209-19.
Nagahara AH, Tuszynski MH. PMID: 21358740.
View in:
PubMed Mentions:
366 Fields:
Translation:
HumansAnimals
-
Time controlled release of arabinofuranosylcytosine (Ara-C) from agarose hydrogels using layer-by-layer assembly: an in vitro study. J Biomater Sci Polym Ed. 2012; 23(1-4):439-63.
Mehrotra S, Lynam D, Liu C, Shahriari D, Lee I, Tuszynski M, Sakamoto J, Chan C. PMID: 21294967; PMCID: PMC3873741.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Structural plasticity within highly specific neuronal populations identifies a unique parcellation of motor learning in the adult brain. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2545-50.
Wang L, Conner JM, Rickert J, Tuszynski MH. PMID: 21257908; PMCID: PMC3038698.
View in:
PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
-
Unconstrained three-dimensional reaching in rhesus monkeys. Exp Brain Res. 2011 Mar; 209(1):35-50.
Jindrich DL, Courtine G, Liu JJ, McKay HL, Moseanko R, Bernot TJ, Roy RR, Zhong H, Tuszynski MH, Reggie Edgerton V. PMID: 21170707; PMCID: PMC3035773.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nat Neurosci. 2010 Dec; 13(12):1505-10.
Rosenzweig ES, Courtine G, Jindrich DL, Brock JH, Ferguson AR, Strand SC, Nout YS, Roy RR, Miller DM, Beattie MS, Havton LA, Bresnahan JC, Edgerton VR, Tuszynski MH. PMID: 21076427; PMCID: PMC3144760.
View in:
PubMed Mentions:
182 Fields:
Translation:
Animals
-
Local and remote growth factor effects after primate spinal cord injury. J Neurosci. 2010 Jul 21; 30(29):9728-37.
Brock JH, Rosenzweig ES, Blesch A, Moseanko R, Havton LA, Edgerton VR, Tuszynski MH. PMID: 20660255; PMCID: PMC2927098.
View in:
PubMed Mentions:
51 Fields:
Translation:
AnimalsCells
-
Regeneration of long-tract axons through sites of spinal cord injury using templated agarose scaffolds. Biomaterials. 2010 Sep; 31(26):6719-29.
Gros T, Sakamoto JS, Blesch A, Havton LA, Tuszynski MH. PMID: 20619785.
View in:
PubMed Mentions:
67 Fields:
Translation:
AnimalsCells
-
Guidance molecules in axon regeneration. Cold Spring Harb Perspect Biol. 2010 Jul; 2(7):a001867.
Giger RJ, Hollis ER, Tuszynski MH. PMID: 20519341; PMCID: PMC2890195.
View in:
PubMed Mentions:
150 Fields:
Translation:
AnimalsCells
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Transient demyelination increases the efficiency of retrograde AAV transduction. Mol Ther. 2010 Aug; 18(8):1496-500.
Hollis ER, Jamshidi P, Lorenzana AO, Lee JK, Gray SJ, Samulski RJ, Zheng B, Tuszynski MH. PMID: 20502445; PMCID: PMC2927074.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
-
A dual promoter lentiviral vector for the in vivo evaluation of gene therapeutic approaches to axon regeneration after spinal cord injury. Gene Ther. 2010 May; 17(5):577-91.
Löw K, Blesch A, Herrmann J, Tuszynski MH. PMID: 20200564.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Unique contributions of distinct cholinergic projections to motor cortical plasticity and learning. Cereb Cortex. 2010 Nov; 20(11):2739-48.
Conner JM, Kulczycki M, Tuszynski MH. PMID: 20181623; PMCID: PMC2951849.
View in:
PubMed Mentions:
44 Fields:
Translation:
Animals
-
Time Controlled Protein Release from Layer-by-Layer Assembled Multilayer Functionalized Agarose Hydrogels. Adv Funct Mater. 2010 Jan 22; 20(2):247-258.
Mehrotra S, Lynam D, Maloney R, Pawelec KM, Tuszynski MH, Lee I, Chan C, Sakamoto J. PMID: 20200599; PMCID: PMC2830720.
View in:
PubMed Mentions:
26
-
Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron. 2009 Oct 29; 64(2):165-72.
Kadoya K, Tsukada S, Lu P, Coppola G, Geschwind D, Filbin MT, Blesch A, Tuszynski MH. PMID: 19874785; PMCID: PMC2773653.
View in:
PubMed Mentions:
104 Fields:
Translation:
AnimalsCells
-
NGF is essential for hippocampal plasticity and learning. J Neurosci. 2009 Sep 02; 29(35):10883-9.
Conner JM, Franks KM, Titterness AK, Russell K, Merrill DA, Christie BR, Sejnowski TJ, Tuszynski MH. PMID: 19726646; PMCID: PMC2765804.
View in:
PubMed Mentions:
78 Fields:
Translation:
AnimalsCells
-
A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth. J Neurosci Res. 2009 Sep; 87(12):2624-31.
Alfa RW, Tuszynski MH, Blesch A. PMID: 19405107; PMCID: PMC2854653.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nat Neurosci. 2009 Sep; 12(9):1106-13.
Alto LT, Havton LA, Conner JM, Hollis ER, Blesch A, Tuszynski MH. PMID: 19648914; PMCID: PMC2753201.
View in:
PubMed Mentions:
95 Fields:
Translation:
AnimalsCells
-
The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity. J Neurosci. 2009 May 06; 29(18):5992-6000.
Ramanathan D, Tuszynski MH, Conner JM. PMID: 19420265; PMCID: PMC6665226.
View in:
PubMed Mentions:
50 Fields:
Translation:
Animals
-
Position statement on the sale of unproven cellular therapies for spinal cord injury: the international campaign for cures of spinal cord injury paralysis. Spinal Cord. 2009 Sep; 47(9):713-4.
Blight A, Curt A, Ditunno JF, Dobkin B, Ellaway P, Fawcett J, Fehlings M, Grossman RG, Lammertse DP, Privat A, Steeves J, Tuszynski M, Kalichman M, Guest JD. PMID: 19417762.
View in:
PubMed Mentions:
13 Fields:
Translation:
Humans
-
Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7215-20.
Hollis ER, Jamshidi P, Löw K, Blesch A, Tuszynski MH. PMID: 19359495; PMCID: PMC2678459.
View in:
PubMed Mentions:
71 Fields:
Translation:
AnimalsCells
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Association of early experience with neurodegeneration in aged primates. Neurobiol Aging. 2011 Jan; 32(1):151-6.
Merrill DA, Masliah E, Roberts JA, McKay H, Kordower JH, Mufson EJ, Tuszynski MH. PMID: 19321231; PMCID: PMC4210191.
View in:
PubMed Mentions:
8 Fields:
Translation:
Animals
-
Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys. J Comp Neurol. 2009 Mar 10; 513(2):151-63.
Rosenzweig ES, Brock JH, Culbertson MD, Lu P, Moseanko R, Edgerton VR, Havton LA, Tuszynski MH. PMID: 19125408; PMCID: PMC2706096.
View in:
PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009 Mar; 15(3):331-7.
Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA, Tuszynski MH. PMID: 19198615; PMCID: PMC2838375.
View in:
PubMed Mentions:
454 Fields:
Translation:
Animals
-
Spinal cord injury: plasticity, regeneration and the challenge of translational drug development. Trends Neurosci. 2009 Jan; 32(1):41-7.
Blesch A, Tuszynski MH. PMID: 18977039.
View in:
PubMed Mentions:
93 Fields:
Translation:
HumansAnimals
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Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Exp Neurol. 2009 Jan; 215(1):153-9.
Nagahara AH, Bernot T, Moseanko R, Brignolo L, Blesch A, Conner JM, Ramirez A, Gasmi M, Tuszynski MH. PMID: 19013154; PMCID: PMC2632603.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury. Exp Neurol. 2009 Jan; 215(1):53-9.
Hollis ER, Lu P, Blesch A, Tuszynski MH. PMID: 18938163; PMCID: PMC2632606.
View in:
PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
-
Age-related cognitive deficits in rhesus monkeys mirror human deficits on an automated test battery. Neurobiol Aging. 2010 Jun; 31(6):1020-31.
Nagahara AH, Bernot T, Tuszynski MH. PMID: 18760505; PMCID: PMC2876823.
View in:
PubMed Mentions:
55 Fields:
Translation:
Animals
-
Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Mol Ther. 2008 Oct; 16(10):1737-44.
Herzog CD, Dass B, Gasmi M, Bakay R, Stansell JE, Tuszynski M, Bankiewicz K, Chen EY, Chu Y, Bishop K, Kordower JH, Bartus RT. PMID: 18728639.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimers Dement. 2008 May; 4(3):156-63.
Khachaturian ZS, Petersen RC, Gauthier S, Buckholtz N, Corey-Bloom JP, Evans B, Fillit H, Foster N, Greenberg B, Grundman M, Sano M, Simpkins J, Schneider LS, Weiner MW, Galasko D, Hyman B, Kuller L, Schenk D, Snyder S, Thomas RG, Tuszynski MH, Vellas B, Wurtman RJ, Snyder PJ, Frank RA, Albert M, Doody R, Ferris S, Kaye J, Koo E, Morrison-Bogorad M, Reisberg B, Salmon DP, Gilman S, Mohs R, Aisen PS, Breitner JC, Cummings JL, Kawas C, Phelps C, Poirier J, Sabbagh M, Touchon J, Khachaturian AS, Bain LJ. PMID: 18631960; PMCID: PMC2544623.
View in:
PubMed Mentions:
12 Fields:
Translation:
Humans
-
Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons. Exp Neurol. 2008 Jun; 211(2):574-84.
Bishop KM, Hofer EK, Mehta A, Ramirez A, Sun L, Tuszynski M, Bartus RT. PMID: 18439998; PMCID: PMC2709503.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Netrin-1 is a novel myelin-associated inhibitor to axon growth. J Neurosci. 2008 Jan 30; 28(5):1099-108.
Löw K, Culbertson M, Bradke F, Tessier-Lavigne M, Tuszynski MH. PMID: 18234888; PMCID: PMC6671394.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Efficient retrograde neuronal transduction utilizing self-complementary AAV1. Mol Ther. 2008 Feb; 16(2):296-301.
Hollis ER, Kadoya K, Hirsch M, Samulski RJ, Tuszynski MH. PMID: 18223548.
View in:
PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
-
Progress and prospects: gene therapy clinical trials (part 2). Gene Ther. 2007 Nov; 14(22):1555-63.
Alton E, Ferrari S, Griesenbach U, Aiuti A, Bachoud-Lévi AC, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA, Leen AM, Lemoine NR, McNeish IA, Meneguzzi G, Peschanski M, Roncarolo MG, Strayer DS, Tuszynski MH, Waxman DJ, Wilson JM. PMID: 17984995.
View in:
PubMed Mentions:
23 Fields:
Translation:
Humans
-
Rebuilding the brain: resurgence of fetal grafting. Nat Neurosci. 2007 Oct; 10(10):1229-30.
Tuszynski MH. PMID: 17893715.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
Transient growth factor delivery sustains regenerated axons after spinal cord injury. J Neurosci. 2007 Sep 26; 27(39):10535-45.
Blesch A, Tuszynski MH. PMID: 17898225; PMCID: PMC6673161.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Growth factors and combinatorial therapies for CNS regeneration. Exp Neurol. 2008 Feb; 209(2):313-20.
Lu P, Tuszynski MH. PMID: 17927983; PMCID: PMC2408882.
View in:
PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Nerve growth factor gene delivery: animal models to clinical trials. Dev Neurobiol. 2007 Aug; 67(9):1204-15.
Tuszynski MH. PMID: 17514712.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
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Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys. Mov Disord. 2007 Jun 15; 22(8):1124-32.
Herzog CD, Dass B, Holden JE, Stansell J, Gasmi M, Tuszynski MH, Bartus RT, Kordower JH. PMID: 17443702.
View in:
PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
-
Nerve growth factor gene therapy in Alzheimer disease. Alzheimer Dis Assoc Disord. 2007 Apr-Jun; 21(2):179-89.
Tuszynski MH. PMID: 17545746.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansAnimals
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Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point. Parkinsonism Relat Disord. 2007; 13 Suppl 3:S469-77.
Bartus RT, Herzog CD, Bishop K, Ostrove JM, Tuszynski M, Kordower JH, Gasmi M. PMID: 18267286.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP Panel: clinical trial inclusion/exclusion criteria and ethics. Spinal Cord. 2007 Mar; 45(3):222-31.
Tuszynski MH, Steeves JD, Fawcett JW, Lammertse D, Kalichman M, Rask C, Curt A, Ditunno JF, Fehlings MG, Guest JD, Ellaway PH, Kleitman N, Bartlett PF, Blight AR, Dietz V, Dobkin BH, Grossman R, Privat A, International Campaign for Cures of Spinal Cord Injury Paralysis. PMID: 17179971.
View in:
PubMed Mentions:
67 Fields:
Translation:
Humans
-
Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures. Spinal Cord. 2007 Mar; 45(3):206-21.
Steeves JD, Lammertse D, Curt A, Fawcett JW, Tuszynski MH, Ditunno JF, Ellaway PH, Fehlings MG, Guest JD, Kleitman N, Bartlett PF, Blight AR, Dietz V, Dobkin BH, Grossman R, Short D, Nakamura M, Coleman WP, Gaviria M, Privat A, International Campaign for Cures of Spinal Cord Injury Paralysis. PMID: 17179972.
View in:
PubMed Mentions:
141 Fields:
Translation:
Humans
-
Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design. Spinal Cord. 2007 Mar; 45(3):232-42.
Lammertse D, Tuszynski MH, Steeves JD, Curt A, Fawcett JW, Rask C, Ditunno JF, Fehlings MG, Guest JD, Ellaway PH, Kleitman N, Blight AR, Dobkin BH, Grossman R, Katoh H, Privat A, Kalichman M, International Campaign for Cures of Spinal Cord Injury Paralysis. PMID: 17179970; PMCID: PMC4106695.
View in:
PubMed Mentions:
65 Fields:
Translation:
Humans
-
Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord. 2007 Mar; 45(3):190-205.
Fawcett JW, Curt A, Steeves JD, Coleman WP, Tuszynski MH, Lammertse D, Bartlett PF, Blight AR, Dietz V, Ditunno J, Dobkin BH, Havton LA, Ellaway PH, Fehlings MG, Privat A, Grossman R, Guest JD, Kleitman N, Nakamura M, Gaviria M, Short D. PMID: 17179973.
View in:
PubMed Mentions:
323 Fields:
Translation:
Humans
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Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF. J Comp Neurol. 2006 Dec 01; 499(4):603-12.
Blurton-Jones M, Tuszynski MH. PMID: 17029253.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Challenges to the report of Nogo antibody effects in primates. Nat Med. 2006 Nov; 12(11):1231-2; author reply 1232-3.
Tuszynski M. PMID: 17088880.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury. J Neurosci. 2006 Oct 25; 26(43):11120-30.
Lu P, Yang H, Culbertson M, Graham L, Roskams AJ, Tuszynski MH. PMID: 17065452; PMCID: PMC6674649.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Axon regeneration through scars and into sites of chronic spinal cord injury. Exp Neurol. 2007 Jan; 203(1):8-21.
Lu P, Jones LL, Tuszynski MH. PMID: 17014846.
View in:
PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
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Templated agarose scaffolds support linear axonal regeneration. Tissue Eng. 2006 Oct; 12(10):2777-87.
Stokols S, Sakamoto J, Breckon C, Holt T, Weiss J, Tuszynski MH. PMID: 17518647.
View in:
PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
-
Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord. J Neurosci. 2006 Sep 20; 26(38):9713-21.
Taylor L, Jones L, Tuszynski MH, Blesch A. PMID: 16988042; PMCID: PMC6674461.
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PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
-
A form of motor cortical plasticity that correlates with recovery of function after brain injury. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11370-5.
Ramanathan D, Conner JM, Tuszynski MH. PMID: 16837575; PMCID: PMC1544093.
View in:
PubMed Mentions:
109 Fields:
Translation:
Animals
-
Clinical trials in spinal cord injury. J Neurotrauma. 2006 Mar-Apr; 23(3-4):586-93.
Blight AR, Tuszynski MH. PMID: 16629639.
View in:
PubMed Mentions:
16 Fields:
Translation:
Humans
-
Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. J Neurosci. 2006 Feb 22; 26(8):2157-66.
Yang H, Lu P, McKay HM, Bernot T, Keirstead H, Steward O, Gage FH, Edgerton VR, Tuszynski MH. PMID: 16495442; PMCID: PMC6674802.
View in:
PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
-
Freeze-dried agarose scaffolds with uniaxial channels stimulate and guide linear axonal growth following spinal cord injury. Biomaterials. 2006 Jan; 27(3):443-51.
Stokols S, Tuszynski MH. PMID: 16099032.
View in:
PubMed Mentions:
89 Fields:
Translation:
AnimalsCells
-
Recommended guidelines for studies of human subjects with spinal cord injury. Spinal Cord. 2005 Aug; 43(8):453-8.
Anderson DK, Beattie M, Blesch A, Bresnahan J, Bunge M, Dietrich D, Dietz V, Dobkin B, Fawcett J, Fehlings M, Fischer I, Grossman R, Guest J, Hagg T, Hall ED, Houle J, Kleitman N, McDonald J, Murray M, Privat A, Reier P, Steeves J, Steward O, Tetzlaff W, Tuszynski MH, Waxman SG, Whittemore S, Wolpaw J, Young W, Zheng B. PMID: 15824756.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
-
Performance of locomotion and foot grasping following a unilateral thoracic corticospinal tract lesion in monkeys (Macaca mulatta). Brain. 2005 Oct; 128(Pt 10):2338-58.
Courtine G, Roy RR, Raven J, Hodgson J, McKay H, Yang H, Zhong H, Tuszynski MH, Edgerton VR. PMID: 16049043.
View in:
PubMed Mentions:
50 Fields:
Translation:
Animals
-
Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons. Mol Ther. 2005 Jun; 11(6):916-25.
Blesch A, Conner J, Pfeifer A, Gasmi M, Ramirez A, Britton W, Alfa R, Verma I, Tuszynski MH. PMID: 15922962.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
Can bone marrow-derived stem cells differentiate into functional neurons? Exp Neurol. 2005 Jun; 193(2):273-8.
Lu P, Tuszynski MH. PMID: 15869931.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med. 2005 May; 11(5):551-5.
Tuszynski MH, Thal L, Pay M, Salmon DP, U HS, Bakay R, Patel P, Blesch A, Vahlsing HL, Ho G, Tong G, Potkin SG, Fallon J, Hansen L, Mufson EJ, Kordower JH, Gall C, Conner J. PMID: 15852017.
View in:
PubMed Mentions:
307 Fields:
Translation:
HumansCellsCTClinical Trials
-
The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury. Neuron. 2005 Apr 21; 46(2):173-9.
Conner JM, Chiba AA, Tuszynski MH. PMID: 15848797.
View in:
PubMed Mentions:
118 Fields:
Translation:
Animals
-
BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol. 2005 Feb; 191(2):344-60.
Lu P, Jones LL, Tuszynski MH. PMID: 15649491.
View in:
PubMed Mentions:
124 Fields:
Translation:
AnimalsCells
-
Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus). J Neurophysiol. 2005 Jun; 93(6):3127-45.
Courtine G, Roy RR, Hodgson J, McKay H, Raven J, Zhong H, Yang H, Tuszynski MH, Edgerton VR. PMID: 15647397.
View in:
PubMed Mentions:
52 Fields:
Translation:
Animals
-
New strategies for CNS repair. Ernst Schering Res Found Workshop. 2005; (53):1-10.
Tuszynski MH. PMID: 16315605.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury. Biomaterials. 2004 Dec; 25(27):5839-46.
Stokols S, Tuszynski MH. PMID: 15172496.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
-
Report of international clinical trials workshop on spinal cord injury February 20-21, 2004, Vancouver, Canada. Spinal Cord. 2004 Oct; 42(10):591-7.
Steeves J, Fawcett J, Tuszynski M. PMID: 15303119.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
-
Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact? J Neurosci Res. 2004 Jul 15; 77(2):174-91.
Lu P, Blesch A, Tuszynski MH. PMID: 15211585.
View in:
PubMed Mentions:
109 Fields:
Translation:
HumansAnimalsCells
-
Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J Neurosci. 2004 Jul 14; 24(28):6402-9.
Lu P, Yang H, Jones LL, Filbin MT, Tuszynski MH. PMID: 15254096; PMCID: PMC6729552.
View in:
PubMed Mentions:
114 Fields:
Translation:
AnimalsCells
-
Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury. Yonsei Med J. 2004 Jun 30; 45 Suppl:28-31.
Blesch A, Tuszynski MH. PMID: 15250047.
View in:
PubMed Mentions:
6 Fields:
Translation:
Humans
-
Stem cells: cross-talk and developmental programs. Philos Trans R Soc Lond B Biol Sci. 2004 May 29; 359(1445):823-37.
Imitola J, Park KI, Teng YD, Nisim S, Lachyankar M, Ourednik J, Mueller FJ, Yiou R, Atala A, Sidman RL, Tuszynski M, Khoury SJ, Snyder EY. PMID: 15293810; PMCID: PMC1693371.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCells
-
Bilateral corticospinal projections arise from each motor cortex in the macaque monkey: a quantitative study. J Comp Neurol. 2004 May 24; 473(2):147-61.
Lacroix S, Havton LA, McKay H, Yang H, Brant A, Roberts J, Tuszynski MH. PMID: 15101086.
View in:
PubMed Mentions:
71 Fields:
Translation:
Animals
-
The ageless question--what accounts for age-related cognitive decline? Sci Aging Knowledge Environ. 2004 May 12; 2004(19):pe20.
Nagahara A, Tuszynski MH. PMID: 15141075.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J Neurosci. 2004 May 05; 24(18):4373-81.
Smith DE, Rapp PR, McKay HM, Roberts JA, Tuszynski MH. PMID: 15128851; PMCID: PMC6729447.
View in:
PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
-
Nucleus hears axon's pain. Nat Med. 2004 Mar; 10(3):236-7.
Blesch A, Tuszynski MH. PMID: 14991043.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression. J Comp Neurol. 2004 Jan 12; 468(3):347-60.
Blurton-Jones M, Kuan PN, Tuszynski MH. PMID: 14681930.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease. Prog Brain Res. 2004; 146:441-9.
Tuszynski MH, Blesch A. PMID: 14699979.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
-
Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. J Comp Neurol. 2003 Dec 15; 467(3):403-17.
Blesch A, Tuszynski MH. PMID: 14608602.
View in:
PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
-
Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration. Exp Neurol. 2003 Nov; 184(1):97-113.
Tobias CA, Shumsky JS, Shibata M, Tuszynski MH, Fischer I, Tessler A, Murray M. PMID: 14637084.
View in:
PubMed Mentions:
74 Fields:
Translation:
AnimalsCells
-
Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition. J Neurosci. 2003 Oct 15; 23(28):9276-88.
Jones LL, Sajed D, Tuszynski MH. PMID: 14561854; PMCID: PMC6740563.
View in:
PubMed Mentions:
109 Fields:
Translation:
AnimalsCells
-
The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol. 2003 Aug; 182(2):399-411.
Jones LL, Margolis RU, Tuszynski MH. PMID: 12895450.
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PubMed Mentions:
218 Fields:
Translation:
AnimalsCells
-
Gene therapy for neurological disease. Expert Opin Biol Ther. 2003 Aug; 3(5):815-28.
Tuszynski MH. PMID: 12880381.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron. 2003 Jun 05; 38(5):819-29.
Conner JM, Culberson A, Packowski C, Chiba AA, Tuszynski MH. PMID: 12797965.
View in:
PubMed Mentions:
147 Fields:
Translation:
AnimalsCells
-
Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol. 2003 Jun; 181(2):115-29.
Lu P, Jones LL, Snyder EY, Tuszynski MH. PMID: 12781986.
View in:
PubMed Mentions:
298 Fields:
Translation:
HumansAnimalsCells
-
NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection. Exp Neurol. 2003 May; 181(1):47-56.
Tuszynski MH, Grill R, Jones LL, Brant A, Blesch A, Löw K, Lacroix S, Lu P. PMID: 12710933.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
-
Hippocampal cell genesis does not correlate with spatial learning ability in aged rats. J Comp Neurol. 2003 Apr 28; 459(2):201-7.
Merrill DA, Karim R, Darraq M, Chiba AA, Tuszynski MH. PMID: 12640670.
View in:
PubMed Mentions:
45 Fields:
Translation:
Animals
-
Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth. J Comp Neurol. 2002 Dec 16; 454(3):213-28.
Lacroix S, Chang L, Rose-John S, Tuszynski MH. PMID: 12442313.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
-
Growth factor gene therapy for Alzheimer disease. Neurosurg Focus. 2002 Nov 15; 13(5):e5.
Tuszynski MH, U HS, Alksne J, Bakay RA, Pay MM, Merrill D, Thal LJ. PMID: 15769074.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
-
Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats. J Comp Neurol. 2002 Oct 21; 452(3):276-87.
Blurton-Jones M, Tuszynski MH. PMID: 12353223.
View in:
PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
-
Nerve growth factor gene therapy for Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):207.
Tuszynski MH, Thal L, U HS, Pay MM, Blesch A, Conner J, Vahlsing HL. PMID: 12212782.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCTClinical Trials
-
Spontaneous and augmented growth of axons in the primate spinal cord: effects of local injury and nerve growth factor-secreting cell grafts. J Comp Neurol. 2002 Jul 15; 449(1):88-101.
Tuszynski MH, Grill R, Jones LL, McKay HM, Blesch A. PMID: 12115695.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
-
Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors. J Neurosci. 2002 Jun 01; 22(11):4611-24.
Jones LL, Tuszynski MH. PMID: 12040068; PMCID: PMC6758783.
View in:
PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
-
Growth-factor gene therapy for neurodegenerative disorders. Lancet Neurol. 2002 May; 1(1):51-7.
Tuszynski MH. PMID: 12849545.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimals
-
Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res Bull. 2002 Apr; 57(6):833-8.
Blesch A, Lu P, Tuszynski MH. PMID: 12031281.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
-
NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci. 2002 Apr 01; 22(7):2792-803.
Jones LL, Yamaguchi Y, Stallcup WB, Tuszynski MH. PMID: 11923444; PMCID: PMC6758310.
View in:
PubMed Mentions:
179 Fields:
Translation:
AnimalsCells
-
New strategies in neural repair. Prog Brain Res. 2002; 138:401-9.
Tuszynski MH, Conner J, Blesch A, Smith D, Merrill DA, Vahlsing HL. PMID: 12432780.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
Therapeutic potential of nervous system growth factors for neurodegenerative disease. Expert Rev Neurother. 2002 Jan; 2(1):89-96.
Merrill DA, Blesch A, Tuszynski MH. PMID: 19811018.
View in:
PubMed Mentions: Fields:
-
Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury. Prog Brain Res. 2002; 137:415-23.
Blesch A, Tuszynski MH. PMID: 12440384.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Spontaneous plasticity in the injured spinal cord-implications for repair strategies. Mol Psychiatry. 2002; 7(1):9-11.
Weidner N, Tuszynski MH. PMID: 11803438.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
-
Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats. J Comp Neurol. 2001 Oct 01; 438(4):445-56.
Merrill DA, Chiba AA, Tuszynski MH. PMID: 11559900.
View in:
PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
-
Chronic intrathecal infusions after spinal cord injury cause scarring and compression. Microsc Res Tech. 2001 Sep 01; 54(5):317-24.
Jones LL, Tuszynski MH. PMID: 11514988.
View in:
PubMed Mentions:
34 Fields:
Translation:
Animals
-
GDNF gene delivery to injured adult CNS motor neurons promotes axonal growth, expression of the trophic neuropeptide CGRP, and cellular protection. J Comp Neurol. 2001 Aug 06; 436(4):399-410.
Blesch A, Tuszynski MH. PMID: 11447585.
View in:
PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
-
Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons. J Comp Neurol. 2001 Aug 06; 436(4):456-70.
Lu P, Blesch A, Tuszynski MH. PMID: 11447589.
View in:
PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
-
Modulation of neuronal survival and axonal growth in vivo by tetracycline-regulated neurotrophin expression. Gene Ther. 2001 Jun; 8(12):954-60.
Blesch A, Conner JM, Tuszynski MH. PMID: 11426336.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury. J Physiol. 2001 May 15; 533(Pt 1):83-9.
Jones LL, Oudega M, Bunge MB, Tuszynski MH. PMID: 11351016; PMCID: PMC2278599.
View in:
PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
-
Reactive astrocytes express estrogen receptors in the injured primate brain. J Comp Neurol. 2001 Apr 23; 433(1):115-23.
Blurton-Jones M, Tuszynski MH. PMID: 11283953.
View in:
PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
-
Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3513-8.
Weidner N, Ner A, Salimi N, Tuszynski MH. PMID: 11248109; PMCID: PMC30684.
View in:
PubMed Mentions:
197 Fields:
Translation:
AnimalsCells
-
Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1941-6.
Conner JM, Darracq MA, Roberts J, Tuszynski MH. PMID: 11172055; PMCID: PMC29361.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
-
Continuous intrathecal fluid infusions elevate nerve growth factor levels and prevent functional deficits after spinal cord ischemia. Brain Res. 2000 Nov 17; 883(2):178-83.
Bowes M, Tuszynski MH, Conner J, Zivin JA. PMID: 11074046.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
-
Intraparenchymal NGF infusions rescue degenerating cholinergic neurons. Cell Transplant. 2000 Sep-Oct; 9(5):629-36.
Tuszynski MH. PMID: 11144960.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Proceedings of the Meeting of the American Society for Neural Transplantation and Repair (ASNTR), 1999. Cell Transplant. 2000 Sep; 9(5):565-566.
Tuszynski MH. PMID: 28880660.
View in:
PubMed Mentions: Fields:
-
Conservation of neuron number and size in entorhinal cortex layers II, III, and V/VI of aged primates. J Comp Neurol. 2000 Jul 03; 422(3):396-401.
Merrill DA, Roberts JA, Tuszynski MH. PMID: 10861515.
View in:
PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
-
Neurite outgrowth can be modulated in vitro using a tetracycline-repressible gene therapy vector expressing human nerve growth factor. J Neurosci Res. 2000 Feb 01; 59(3):402-9.
Blesch A, Uy HS, Diergardt N, Tuszynski MH. PMID: 10679776.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Neurotrophic factors and gene therapy in spinal cord injury. Neurorehabil Neural Repair. 2000; 14(4):265-75.
Lacroix S, Tuszynski MH. PMID: 11402877.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
-
Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1. J Comp Neurol. 1999 Nov 01; 413(4):495-506.
Weidner N, Blesch A, Grill RJ, Tuszynski MH. PMID: 10495438.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
-
Elimination of basal lamina and the collagen "scar" after spinal cord injury fails to augment corticospinal tract regeneration. Exp Neurol. 1999 Nov; 160(1):40-50.
Weidner N, Grill RJ, Tuszynski MH. PMID: 10630189.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10893-8.
Smith DE, Roberts J, Gage FH, Tuszynski MH. PMID: 10485922; PMCID: PMC17979.
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PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
-
Human spinal cord retains substantial structural mass in chronic stages after injury. J Neurotrauma. 1999 Jun; 16(6):523-31.
Tuszynski MH, Gabriel K, Gerhardt K, Szollar S. PMID: 10391368.
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PubMed Mentions:
14 Fields:
Translation:
Humans
-
Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury. J Neurosci. 1999 May 01; 19(9):3556-66.
Blesch A, Uy HS, Grill RJ, Cheng JG, Patterson PH, Tuszynski MH. PMID: 10212315; PMCID: PMC6782234.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
-
Estrogen receptor immunoreactivity in the adult primate brain: neuronal distribution and association with p75, trkA, and choline acetyltransferase. J Comp Neurol. 1999 Mar 22; 405(4):529-42.
Blurton-Jones MM, Roberts JA, Tuszynski MH. PMID: 10098943.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
Recovery of locomotion after experimental spinal cord injury: axonal regeneration or modulation of intrinsic spinal cord walking circuitry? J Spinal Cord Med. 1999; 22(2):143.
Tuszynski M, Edgerton R, Dobkin B. PMID: 10826273.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Targeted intraparenchymal delivery of human NGF by gene transfer to the primate basal forebrain for 3 months does not accelerate beta-amyloid plaque deposition. Exp Neurol. 1998 Dec; 154(2):573-82.
Tuszynski MH, Smith DE, Roberts J, McKay H, Mufson E. PMID: 9878192.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
-
Grafts of genetically modified Schwann cells to the spinal cord: survival, axon growth, and myelination. Cell Transplant. 1998 Mar-Apr; 7(2):187-96.
Tuszynski MH, Weidner N, McCormack M, Miller I, Powell H, Conner J. PMID: 9588600.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
-
Neurotrophin gene therapy in CNS models of trauma and degeneration. Prog Brain Res. 1998; 117:473-84.
Blesch A, Grill RJ, Tuszynski MH. PMID: 9932426.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
-
Gene therapy for nervous system disease. Ann N Y Acad Sci. 1997 Dec 19; 835:1-11.
Tuszynski MH. PMID: 9616757.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
-
Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells. Exp Neurol. 1997 Dec; 148(2):444-52.
Grill RJ, Blesch A, Tuszynski MH. PMID: 9417824.
View in:
PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
-
Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci. 1997 Jul 15; 17(14):5560-72.
Grill R, Murai K, Blesch A, Gage FH, Tuszynski MH. PMID: 9204937; PMCID: PMC6793805.
View in:
PubMed Mentions:
132 Fields:
Translation:
AnimalsCells
-
Cerebral glucose metabolism and memory in aged rhesus macaques. Neurobiol Aging. 1997 Jul-Aug; 18(4):437-43.
Eberling JL, Roberts JA, Rapp PR, Tuszynski MH, Jagust WJ. PMID: 9330976.
View in:
PubMed Mentions:
11 Fields:
Translation:
Animals
-
Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cord. Cell Transplant. 1997 May-Jun; 6(3):361-8.
Tuszynski MH, Murai K, Blesch A, Grill R, Miller I. PMID: 9171168.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
-
Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor. Ann Neurol. 1997 Jan; 41(1):82-93.
Winkler J, Ramirez GA, Kuhn HG, Peterson DA, Day-Lollini PA, Stewart GR, Tuszynski MH, Gage FH, Thal LJ. PMID: 9005869.
View in:
PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
-
A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neurology. 1996 Sep; 47(3):705-11.
Thal LJ, Carta A, Clarke WR, Ferris SH, Friedland RP, Petersen RC, Pettegrew JW, Pfeiffer E, Raskind MA, Sano M, Tuszynski MH, Woolson RF. PMID: 8797468.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansCTClinical Trials
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Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Ther. 1996 Apr; 3(4):305-14.
Tuszynski MH, Roberts J, Senut MC, U HS, Gage FH. PMID: 8732162.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons. Neuroscience. 1996 Apr; 71(3):761-71.
Tuszynski MH, Mafong E, Meyer S. PMID: 8867048.
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PubMed Mentions:
18 Fields:
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AnimalsCells
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Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord. Cell Transplant. 1996 Mar-Apr; 5(2):191-204.
Nakahara Y, Gage FH, Tuszynski MH. PMID: 8689031.
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PubMed Mentions:
30 Fields:
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HumansAnimalsCells
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Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury. Exp Neurol. 1996 Jan; 137(1):157-73.
Tuszynski MH, Gabriel K, Gage FH, Suhr S, Meyer S, Rosetti A. PMID: 8566208.
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PubMed Mentions:
50 Fields:
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AnimalsCells
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Somatic gene therapy for nervous system disease. Ciba Found Symp. 1996; 196:85-94; discussion 94-7.
Tuszynski MH, Gage FH. PMID: 8866129.
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HumansAnimals
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Regional differences in responsiveness of adult CNS axons to grafts of cells expressing human neurotrophin 3. Exp Neurol. 1995 Sep; 135(1):36-55.
Senut MC, Tuszynski MH, Raymon HK, Suhr ST, Liou NH, Jones KR, Reichardt LF, Gage FH. PMID: 7556552.
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PubMed Mentions:
9 Fields:
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HumansAnimalsCells
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Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4621-5.
Tuszynski MH, Gage FH. PMID: 7753852; PMCID: PMC41996.
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PubMed Mentions:
19 Fields:
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AnimalsCells
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Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy. Mol Neurobiol. 1995 Apr-Jun; 10(2-3):151-67.
Tuszynski MH, Gage FH. PMID: 7576305.
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PubMed Mentions:
9 Fields:
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AnimalsCells
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Ex vivo gene therapy for Alzheimer's disease and spinal cord injury. Clin Neurosci. 1995-1996; 3(5):268-74.
Blesch A, Tuszynski M. PMID: 8914793.
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PubMed Mentions:
6 Fields:
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HumansAnimalsCells
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Somatic gene transfer to the adult primate central nervous system: in vitro and in vivo characterization of cells genetically modified to secrete nerve growth factor. Neurobiol Dis. 1994 Nov; 1(1-2):67-78.
Tuszynski MH, Senut MC, Ray J, Roberts J. PMID: 9216988.
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PubMed Mentions:
5 Fields:
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AnimalsCells
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Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Exp Neurol. 1994 Mar; 126(1):1-14.
Tuszynski MH, Peterson DA, Ray J, Baird A, Nakahara Y, Gage FH. PMID: 8157119.
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PubMed Mentions:
40 Fields:
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HumansAnimalsCells
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Neurotrophic factors and diseases of the nervous system. Ann Neurol. 1994; 35 Suppl:S9-12.
Tuszynski MH, Gage FH. PMID: 8185304.
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PubMed Mentions:
3 Fields:
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HumansAnimals
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Ataxia in epidural spinal cord compression. Neurology. 1992 Nov; 42(11):2193-5.
Hainline B, Tuszynski MH, Posner JB. PMID: 1436534.
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PubMed Mentions:
5 Fields:
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Humans
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Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain. Ann Neurol. 1991 Nov; 30(5):625-36.
Tuszynski MH, Sang H, Yoshida K, Gage FH. PMID: 1763889.
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PubMed Mentions:
28 Fields:
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AnimalsCells
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In vivo assay of neuron-specific effects of nerve growth factor. Methods Enzymol. 1991; 198:35-48.
Tuszynski MH, Gage FH. PMID: 1857228.
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AnimalsCells
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Nerve growth factor function in the central nervous system. Curr Top Microbiol Immunol. 1991; 165:71-93.
Gage FH, Tuszynski MH, Chen KS, Fagan AM, Higgins GA. PMID: 2032465.
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PubMed Mentions:
4 Fields:
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AnimalsCells
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Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration. J Neurosci. 1990 Nov; 10(11):3604-14.
Tuszynski MH, U HS, Amaral DG, Gage FH. PMID: 2230949; PMCID: PMC6570113.
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PubMed Mentions:
54 Fields:
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AnimalsCells
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Human beta nerve growth factor obtained from a baculovirus expression system has potent in vitro and in vivo neurotrophic activity. Exp Neurol. 1990 Oct; 110(1):11-24.
Barnett J, Baecker P, Routledge-Ward C, Bursztyn-Pettegrew H, Chow J, Nguyen B, Bach C, Chan H, Tuszynski MH, Yoshida K, et al. PMID: 2209779.
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PubMed Mentions:
9 Fields:
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HumansAnimalsCells
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Basal forebrain cell loss following fimbria/fornix transection. Brain Res. 1990 Feb 05; 508(2):241-8.
Tuszynski MH, Armstrong DM, Gage FH. PMID: 2306615.
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PubMed Mentions:
8 Fields:
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AnimalsCells
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Grafting genetically modified cells to the brain: conceptual and technical issues. Prog Brain Res. 1990; 82:1-10.
Gage FH, Fisher LJ, Jinnah HA, Rosenberg MB, Tuszynski MH, Friedmann T. PMID: 1981271.
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PubMed Mentions:
2 Fields:
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HumansAnimalsCells
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Gene therapy in the CNS: intracerebral grafting of genetically modified cells. Prog Brain Res. 1990; 86:205-17.
Gage FH, Rosenberg MB, Tuszynski MH, Yoshida K, Armstrong DM, Hayes RC, Friedmann T. PMID: 2087558.
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PubMed Mentions:
5 Fields:
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AnimalsCells
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Nerve growth factor infusions combined with fetal hippocampal grafts enhance reconstruction of the lesioned septohippocampal projection. Neuroscience. 1990; 36(1):33-44.
Tuszynski MH, Buzsaki G, Gage FH. PMID: 1699159.
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PubMed Mentions:
6 Fields:
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AnimalsCells
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Potential use of neurotrophic agents in the treatment of neurodegenerative disorders. Acta Neurobiol Exp (Wars). 1990; 50(4-5):311-22.
Tuszynski MH, Gage FH. PMID: 2130651.
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PubMed Mentions:
3 Fields:
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HumansAnimals
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Role of neurotrophic factors in Alzheimer's disease. Neurobiol Aging. 1989 Sep-Oct; 10(5):545-6; discussion 552-3.
Chen KS, Tuszynski MH, Gage FH. PMID: 2812224.
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PubMed Mentions:
2 Fields:
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Humans
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Delivery of neuroactive compounds to the brain: potential utility of genetically modified cells. Neurobiol Aging. 1989 Sep-Oct; 10(5):644-5; discussion 648-50.
Tuszynski MH, Jinnah HA, Gage FH. PMID: 2812247.
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Humans
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Survival, growth and function of damaged cholinergic neurons. EXS. 1989; 57:259-74.
Gage FH, Tuszynski MH, Chen KS, Armstrong D, Buzsáki G. PMID: 2533097.
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PubMed Mentions:
3 Translation:
AnimalsCells
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Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression. Science. 1988 Dec 16; 242(4885):1575-8.
Rosenberg MB, Friedmann T, Robertson RC, Tuszynski M, Wolff JA, Breakefield XO, Gage FH. PMID: 3201248.
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PubMed Mentions:
51 Fields:
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AnimalsCells
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Ischemic thalamic aphasia with pathologic confirmation. Neurology. 1988 May; 38(5):800-2.
Tuszynski MH, Petito CK. PMID: 3362379.
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PubMed Mentions:
6 Fields:
Translation:
Humans