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Mark Tuszynski

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentNeurosciences
Address9500 Gilman Drive #0626
La Jolla CA 92093
Phone858-534-8857
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    Collapse Research 
    Collapse Research Activities and Funding
    ShEEP request for a Zeiss LSM 880 with Airyscan confocal system
    VA IS1BX004001Jan 1, 2018 - Sep 30, 2018
    Role: Principal Investigator
    Embryonic stem cell therapy after cervical contusion SCI in NHPs
    NIH/NINDS R01NS105478Sep 25, 2017 - Jun 30, 2022
    Role: Co-Principal Investigator
    3D Printed Scaffolds for Primate Spinal Cord Injury
    NIH/NINDS R03NS104972Sep 22, 2017 - Aug 31, 2019
    Role: Principal Investigator
    The Primate Corticospinal Connectome
    NIH/NINDS R01NS104442Sep 15, 2017 - May 31, 2021
    Role: Principal Investigator
    The VA Gordon Mansfield SCI Consortium
    VA I50RX001706Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Acquisition of a Keyence BZ-X700 All-In-One Automated Imaging System
    VA IS1BX003125Jan 1, 2015 - Sep 30, 2015
    Role: Principal Investigator
    A Translational Program of BDNF Gene Delivery in Alzheimer's Disease
    NIH/NIA U01AG043416Jun 15, 2014 - May 31, 2019
    Role: Principal Investigator
    Bioengineered Scaffolds for Spinal Cord Injury
    NIH/NIBIB R01EB014986May 15, 2012 - Apr 30, 2017
    Role: Principal Investigator
    Contusive Spinal Cord Injury Model Development
    VA I01RX000434Oct 1, 2010 - Sep 30, 2012
    Role: Principal Investigator
    Combinatorial Approaches to SCI
    NIH/NINDS R01NS049881Aug 3, 2004 - Apr 30, 2010
    Role: Principal Investigator
    Plasticity and Regeneration in the Primate Spinal Cord
    NIH/NINDS R56NS042291Sep 1, 2001 - Mar 31, 2018
    Role: Principal Investigator
    Plasticity and Regeneration in the Primate Spinal Cord
    NIH/NINDS R01NS042291Sep 1, 2001 - Mar 31, 2016
    Role: Principal Investigator
    Netrins and Gene Therapy After Spinal Cord Injury
    NIH/NINDS R21NS042038Jul 15, 2001 - Jun 30, 2004
    Role: Principal Investigator
    Neurobiological Aspects of Aging
    NIH/NIA K12AG000975Apr 1, 2000 - Mar 31, 2012
    Role: Principal Investigator
    EX VIVO SCHWANN CELL GENE THERAPY FOR CNS REPAIR
    NIH/NINDS R01NS037083Dec 1, 1997 - Nov 30, 2001
    Role: Principal Investigator
    Gene Therapy for Alzheimer's Disease
    NIH/NIA P01AG010435Sep 30, 1991 - Mar 31, 2015
    Role: Principal Investigator
    CHOLINERGIC NEURONAL REGENERATION IN THE CNS
    NIH/NINDS F32NS008200Oct 21, 1987
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH/NIA P50AG005131Sep 28, 1984 - Mar 31, 2019
    Role: Co-Investigator
    California National Primate Research Center
    NIH P51RR000169Jun 1, 1975 - Apr 30, 2015
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Castle MJ, Cheng Y, Asokan A, Tuszynski MH. Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion. Sci Adv. 2018 Nov; 4(11):eaau9859. PMID: 30443600.
      View in: PubMed
    2. Kumamaru H, Lu P, Rosenzweig ES, Tuszynski MH. Activation of Intrinsic Growth State Enhances Host Axonal Regeneration into Neural Progenitor Cell Grafts. Stem Cell Reports. 2018 Aug 28. PMID: 30197116.
      View in: PubMed
    3. Kumamaru H, Kadoya K, Adler AF, Takashima Y, Graham L, Coppola G, Tuszynski MH. Generation and post-injury integration of human spinal cord neural stem cells. Nat Methods. 2018 Aug 06. PMID: 30082899.
      View in: PubMed
    4. Poplawski GHD, Lie R, Hunt M, Kumamaru H, Kawaguchi R, Lu P, Schäfer MKE, Woodruff G, Robinson J, Canete P, Dulin JN, Geoffroy CG, Menzel L, Zheng B, Coppola G, Tuszynski MH. Adult rat myelin enhances axonal outgrowth from neural stem cells. Sci Transl Med. 2018 May 23; 10(442). PMID: 29794059.
      View in: PubMed
    5. Rafii MS, Tuszynski MH, Thomas RG, Barba D, Brewer JB, Rissman RA, Siffert J, Aisen PS. Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2018 Mar 26. PMID: 29582053.
      View in: PubMed
    6. Nagahara AH, Wilson BR, Ivasyk I, Kovacs I, Rawalji S, Bringas JR, Pivirotto PJ, Sebastian WS, Samaranch L, Bankiewicz KS, Tuszynski MH. MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates. Gene Ther. 2018 Mar 13. PMID: 29535375.
      View in: PubMed
    7. Brock JH, Graham L, Staufenberg E, Im S, Tuszynski MH. Rodent Neural Progenitor Cells Support Functional Recovery after Cervical Spinal Cord Contusion. J Neurotrauma. 2018 May 01; 35(9):1069-1078. PMID: 29279015.
      View in: PubMed
    8. Rosenzweig ES, Brock JH, Lu P, Kumamaru H, Salegio EA, Kadoya K, Weber JL, Liang JJ, Moseanko R, Hawbecker S, Huie JR, Havton LA, Nout-Lomas YS, Ferguson AR, Beattie MS, Bresnahan JC, Tuszynski MH. Restorative effects of human neural stem cell grafts on the primate spinal cord. Nat Med. 2018 May; 24(4):484-490. PMID: 29480894.
      View in: PubMed
    9. Zuidema JM, Kumeria T, Kim D, Kang J, Wang J, Hollett G, Zhang X, Roberts DS, Chan N, Dowling C, Blanco-Suarez E, Allen NJ, Tuszynski MH, Sailor MJ. Oriented Nanofibrous Polymer Scaffolds Containing Protein-Loaded Porous Silicon Generated by Spray Nebulization. Adv Mater. 2018 Mar; 30(12):e1706785. PMID: 29363828.
      View in: PubMed
    10. Dulin JN, Adler AF, Kumamaru H, Poplawski GHD, Lee-Kubli C, Strobl H, Gibbs D, Kadoya K, Fawcett JW, Lu P, Tuszynski MH. Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts. Nat Commun. 2018 01 08; 9(1):84. PMID: 29311559.
      View in: PubMed
    11. Shahriari D, Shibayama M, Lynam DA, Wolf KJ, Kubota G, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS. Peripheral nerve growth within a hydrogel microchannel scaffold supported by a kink-resistant conduit. J Biomed Mater Res A. 2017 Dec; 105(12):3392-3399. PMID: 28804998.
      View in: PubMed
    12. Lu P, Ceto S, Wang Y, Graham L, Wu D, Kumamaru H, Staufenberg E, Tuszynski MH. Prolonged human neural stem cell maturation supports recovery in injured rodent CNS. J Clin Invest. 2017 Sep 01; 127(9):3287-3299. PMID: 28825600.
      View in: PubMed
    13. Hunt M, Lu P, Tuszynski MH. Myelination of axons emerging from neural progenitor grafts after spinal cord injury. Exp Neurol. 2017 10; 296:69-73. PMID: 28698030.
      View in: PubMed
    14. Adler AF, Lee-Kubli C, Kumamaru H, Kadoya K, Tuszynski MH. Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury. Stem Cell Reports. 2017 06 06; 8(6):1525-1533. PMID: 28479302.
      View in: PubMed
    15. Lu P, Tuszynski MH. Introduction to neuroscience letters special issue: "Plasticity and regeneration after spinal cord injury". Neurosci Lett. 2017 06 23; 652:1-2. PMID: 28432027.
      View in: PubMed
    16. Shahriari D, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS. Hierarchically Ordered Porous and High-Volume Polycaprolactone Microchannel Scaffolds Enhanced Axon Growth in Transected Spinal Cords. Tissue Eng Part A. 2017 05; 23(9-10):415-425. PMID: 28107810.
      View in: PubMed
    17. Hollis Ii ER, Kadoya K, Hirsch M, Samulski RJ, Tuszynski MH. Efficient Retrograde Neuronal Transduction Utilizing Self-complementary AAV1. Mol Ther. 2008 Feb; 16(2):296-301. PMID: 28178539.
      View in: PubMed
    18. Gao M, Lu P, Lynam D, Bednark B, Campana WM, Sakamoto J, Tuszynski M. BDNF gene delivery within and beyond templated agarose multi-channel guidance scaffolds enhances peripheral nerve regeneration. J Neural Eng. 2016 Dec; 13(6):066011. PMID: 27762235.
      View in: PubMed
    19. Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time. Nature. 2016 06 02; 534(7605):115-8. PMID: 27251287.
      View in: PubMed
    20. Kadoya K, Lu P, Nguyen K, Lee-Kubli C, Kumamaru H, Yao L, Knackert J, Poplawski G, Dulin JN, Strobl H, Takashima Y, Biane J, Conner J, Zhang SC, Tuszynski MH. Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration. Nat Med. 2016 05; 22(5):479-87. PMID: 27019328; PMCID: PMC4860037.
    21. Biane JS, Takashima Y, Scanziani M, Conner JM, Tuszynski MH. Thalamocortical Projections onto Behaviorally Relevant Neurons Exhibit Plasticity during Adult Motor Learning. Neuron. 2016 Mar 16; 89(6):1173-1179. PMID: 26948893; PMCID: PMC4795975 [Available on 03/16/17].
    22. Wang L, Conner JM, Nagahara AH, Tuszynski MH. Rehabilitation drives enhancement of neuronal structure in functionally relevant neuronal subsets. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):2750-5. PMID: 26903653; PMCID: PMC4790976.
    23. Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. 2016 Mar 02; 89(5):956-70. PMID: 26898779; PMCID: PMC4790095 [Available on 03/02/17].
    24. Lee-Kubli CA, Ingves M, Henry KW, Shiao R, Collyer E, Tuszynski MH, Campana WM. Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury. Exp Neurol. 2016 Apr; 278:91-104. PMID: 26808661.
      View in: PubMed
    25. Salegio EA, Bresnahan JC, Sparrey CJ, Camisa W, Fischer J, Leasure J, Buckley J, Nout-Lomas YS, Rosenzweig ES, Moseanko R, Strand S, Hawbecker S, Lemoy MJ, Haefeli J, Ma X, Nielson JL, Edgerton VR, Ferguson AR, Tuszynski MH, Beattie MS. A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta). J Neurotrauma. 2016 Mar 01; 33(5):439-59. PMID: 26788611; PMCID: PMC4799702.
    26. van Niekerk EA, Tuszynski MH, Lu P, Dulin JN. Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury. Mol Cell Proteomics. 2016 Feb; 15(2):394-408. PMID: 26695766; PMCID: PMC4739663 [Available on 02/01/17].
    27. Brock JH, Graham L, Staufenberg E, Collyer E, Koffler J, Tuszynski MH. Bone Marrow Stromal Cell Intraspinal Transplants Fail to Improve Motor Outcomes in a Severe Model of Spinal Cord Injury. J Neurotrauma. 2016 Jun 15; 33(12):1103-14. PMID: 26414795; PMCID: PMC4904236 [Available on 06/15/17].
    28. Shahriari D, Koffler J, Lynam DA, Tuszynski MH, Sakamoto JS. Characterizing the degradation of alginate hydrogel for use in multilumen scaffolds for spinal cord repair. J Biomed Mater Res A. 2016 Mar; 104(3):611-619. PMID: 26488452.
      View in: PubMed
    29. Dulin JN, Antunes-Martins A, Chandran V, Costigan M, Lerch JK, Willis DE, Tuszynski MH. Transcriptomic Approaches to Neural Repair. J Neurosci. 2015 Oct 14; 35(41):13860-7. PMID: 26468186; PMCID: PMC4604224.
    30. Tuszynski MH, Yang JH, Barba D, U HS, Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, Nagahara AH. Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease. JAMA Neurol. 2015 Oct; 72(10):1139-47. PMID: 26302439; PMCID: PMC4944824.
    31. Friedli L, Rosenzweig ES, Barraud Q, Schubert M, Dominici N, Awai L, Nielson JL, Musienko P, Nout-Lomas Y, Zhong H, Zdunowski S, Roy RR, Strand SC, van den Brand R, Havton LA, Beattie MS, Bresnahan JC, Bézard E, Bloch J, Edgerton VR, Ferguson AR, Curt A, Tuszynski MH, Courtine G. Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates. Sci Transl Med. 2015 Aug 26; 7(302):302ra134. PMID: 26311729.
      View in: PubMed
    32. Biane JS, Scanziani M, Tuszynski MH, Conner JM. Motor cortex maturation is associated with reductions in recurrent connectivity among functional subpopulations and increases in intrinsic excitability. J Neurosci. 2015 Mar 18; 35(11):4719-28. PMID: 25788688; PMCID: PMC4363396.
    33. Lynam DA, Shahriari D, Wolf KJ, Angart PA, Koffler J, Tuszynski MH, Chan C, Walton P, Sakamoto J. Brain derived neurotrophic factor release from layer-by-layer coated agarose nerve guidance scaffolds. Acta Biomater. 2015 May; 18:128-31. PMID: 25712385.
      View in: PubMed
    34. Ramanathan DS, Conner JM, Anilkumar AA, Tuszynski MH. Cholinergic systems are essential for late-stage maturation and refinement of motor cortical circuits. J Neurophysiol. 2015 Mar 01; 113(5):1585-97. PMID: 25505106; PMCID: PMC4346727.
    35. Nielson JL, Haefeli J, Salegio EA, Liu AW, Guandique CF, Stück ED, Hawbecker S, Moseanko R, Strand SC, Zdunowski S, Brock JH, Roy RR, Rosenzweig ES, Nout-Lomas YS, Courtine G, Havton LA, Steward O, Reggie Edgerton V, Tuszynski MH, Beattie MS, Bresnahan JC, Ferguson AR. Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury. Brain Res. 2015 Sep 04; 1619:124-38. PMID: 25451131; PMCID: PMC4418964.
    36. Biane J, Conner JM, Tuszynski MH. Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex. Front Cell Neurosci. 2014; 8:220. PMID: 25147503; PMCID: PMC4124705.
    37. Lu P, Woodruff G, Wang Y, Graham L, Hunt M, Wu D, Boehle E, Ahmad R, Poplawski G, Brock J, Goldstein LS, Tuszynski MH. Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury. Neuron. 2014 Aug 20; 83(4):789-96. PMID: 25123310; PMCID: PMC4144679.
    38. Nielson JL, Guandique CF, Liu AW, Burke DA, Lash AT, Moseanko R, Hawbecker S, Strand SC, Zdunowski S, Irvine KA, Brock JH, Nout-Lomas YS, Gensel JC, Anderson KD, Segal MR, Rosenzweig ES, Magnuson DS, Whittemore SR, McTigue DM, Popovich PG, Rabchevsky AG, Scheff SW, Steward O, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC, Ferguson AR. Development of a database for translational spinal cord injury research. J Neurotrauma. 2014 Nov 01; 31(21):1789-99. PMID: 25077610; PMCID: PMC4186058.
    39. Tuszynski MH, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. Neural stem cells in models of spinal cord injury. Exp Neurol. 2014 Nov; 261:494-500. PMID: 25079369.
      View in: PubMed
    40. Lu P, Graham L, Wang Y, Wu D, Tuszynski M. Promotion of survival and differentiation of neural stem cells with fibrin and growth factor cocktails after severe spinal cord injury. J Vis Exp. 2014 Jul 27; (89):e50641. PMID: 25145787; PMCID: PMC4435462.
    41. Lu P, Kadoya K, Tuszynski MH. Axonal growth and connectivity from neural stem cell grafts in models of spinal cord injury. Curr Opin Neurobiol. 2014 Aug; 27:103-9. PMID: 24709371.
      View in: PubMed
    42. Tuszynski MH, Wang Y, Graham L, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. Neural stem cell dissemination after grafting to CNS injury sites. Cell. 2014 Jan 30; 156(3):388-9. PMID: 24485445.
      View in: PubMed
    43. Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo EH, Masliah E, Tuszynski MH. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci. 2013 Sep 25; 33(39):15596-602. PMID: 24068826; PMCID: PMC3782628.
    44. Do JL, Bonni A, Tuszynski MH. SnoN facilitates axonal regeneration after spinal cord injury. PLoS One. 2013; 8(8):e71906. PMID: 23936531; PMCID: PMC3732222.
    45. Yoon C, Van Niekerk EA, Henry K, Ishikawa T, Orita S, Tuszynski MH, Campana WM. Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration. J Biol Chem. 2013 Sep 13; 288(37):26557-68. PMID: 23867460; PMCID: PMC3772203.
    46. Ommaya AK, Adams KM, Allman RM, Collins EG, Cooper RA, Dixon CE, Fishman PS, Henry JA, Kardon R, Kerns RD, Kupersmith J, Lo A, Macko R, McArdle R, McGlinchey RE, McNeil MR, O'Toole TP, Peckham PH, Tuszynski MH, Waxman SG, Wittenberg GF. Guest editorial: Opportunities in rehabilitation research. J Rehabil Res Dev. 2013; 50(6):vii-xxxii. PMID: 24203548; PMCID: PMC4599704.
    47. Gao M, Lu P, Bednark B, Lynam D, Conner JM, Sakamoto J, Tuszynski MH. Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection. Biomaterials. 2013 Feb; 34(5):1529-36. PMID: 23182350; PMCID: PMC3518618.
    48. Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Tuszynski MH. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012 Sep 14; 150(6):1264-73. PMID: 22980985; PMCID: PMC3445432.
    49. Yoon SO, Park DJ, Ryu JC, Ozer HG, Tep C, Shin YJ, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski MH, Huang K. JNK3 perpetuates metabolic stress induced by Aß peptides. Neuron. 2012 Sep 06; 75(5):824-37. PMID: 22958823; PMCID: PMC3438522.
    50. Lu P, Blesch A, Graham L, Wang Y, Samara R, Banos K, Haringer V, Havton L, Weishaupt N, Bennett D, Fouad K, Tuszynski MH. Motor axonal regeneration after partial and complete spinal cord transection. J Neurosci. 2012 Jun 13; 32(24):8208-18. PMID: 22699902; PMCID: PMC3407545.
    51. Tuszynski MH, Steward O. Concepts and methods for the study of axonal regeneration in the CNS. Neuron. 2012 Jun 07; 74(5):777-91. PMID: 22681683; PMCID: PMC3387806.
    52. Nout YS, Rosenzweig ES, Brock JH, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Courtine G, Ferguson AR, Edgerton VR, Beattie MS, Bresnahan JC, Tuszynski MH. Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury. Neurotherapeutics. 2012 Apr; 9(2):380-92. PMID: 22427157; PMCID: PMC3337011.
    53. Nout YS, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Zhong H, Rosenzweig ES, Brock JH, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC. Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey. Neurorehabil Neural Repair. 2012 Jul-Aug; 26(6):556-69. PMID: 22331214; PMCID: PMC3468651.
    54. Blesch A, Fischer I, Tuszynski MH. Gene therapy, neurotrophic factors and spinal cord regeneration. Handb Clin Neurol. 2012; 109:563-74. PMID: 23098737.
      View in: PubMed
    55. Yoon C, Tuszynski MH. Frontiers of spinal cord and spine repair: experimental approaches for repair of spinal cord injury. Adv Exp Med Biol. 2012; 760:1-15. PMID: 23281510.
      View in: PubMed
    56. Blesch A, Lu P, Tsukada S, Alto LT, Roet K, Coppola G, Geschwind D, Tuszynski MH. Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: superiority to camp-mediated effects. Exp Neurol. 2012 May; 235(1):162-73. PMID: 22227059; PMCID: PMC3334479.
    57. Hollis ER, Tuszynski MH. Neurotrophins: potential therapeutic tools for the treatment of spinal cord injury. Neurotherapeutics. 2011 Oct; 8(4):694-703. PMID: 21904786; PMCID: PMC3250295.
    58. Nagahara AH, Tuszynski MH. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov. 2011 Mar; 10(3):209-19. PMID: 21358740.
      View in: PubMed
    59. Mehrotra S, Lynam D, Liu C, Shahriari D, Lee I, Tuszynski M, Sakamoto J, Chan C. Time controlled release of arabinofuranosylcytosine (Ara-C) from agarose hydrogels using layer-by-layer assembly: an in vitro study. J Biomater Sci Polym Ed. 2012; 23(1-4):439-63. PMID: 21294967; PMCID: PMC3873741.
    60. Wang L, Conner JM, Rickert J, Tuszynski MH. Structural plasticity within highly specific neuronal populations identifies a unique parcellation of motor learning in the adult brain. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2545-50. PMID: 21257908; PMCID: PMC3038698.
    61. Jindrich DL, Courtine G, Liu JJ, McKay HL, Moseanko R, Bernot TJ, Roy RR, Zhong H, Tuszynski MH, Reggie Edgerton V. Unconstrained three-dimensional reaching in rhesus monkeys. Exp Brain Res. 2011 Mar; 209(1):35-50. PMID: 21170707; PMCID: PMC3035773.
    62. Rosenzweig ES, Courtine G, Jindrich DL, Brock JH, Ferguson AR, Strand SC, Nout YS, Roy RR, Miller DM, Beattie MS, Havton LA, Bresnahan JC, Edgerton VR, Tuszynski MH. Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nat Neurosci. 2010 Dec; 13(12):1505-10. PMID: 21076427; PMCID: PMC3144760.
    63. Brock JH, Rosenzweig ES, Blesch A, Moseanko R, Havton LA, Edgerton VR, Tuszynski MH. Local and remote growth factor effects after primate spinal cord injury. J Neurosci. 2010 Jul 21; 30(29):9728-37. PMID: 20660255; PMCID: PMC2927098.
    64. Gros T, Sakamoto JS, Blesch A, Havton LA, Tuszynski MH. Regeneration of long-tract axons through sites of spinal cord injury using templated agarose scaffolds. Biomaterials. 2010 Sep; 31(26):6719-29. PMID: 20619785.
      View in: PubMed
    65. Giger RJ, Hollis ER, Tuszynski MH. Guidance molecules in axon regeneration. Cold Spring Harb Perspect Biol. 2010 Jul; 2(7):a001867. PMID: 20519341; PMCID: PMC2890195.
    66. Hollis ER, Jamshidi P, Lorenzana AO, Lee JK, Gray SJ, Samulski RJ, Zheng B, Tuszynski MH. Transient demyelination increases the efficiency of retrograde AAV transduction. Mol Ther. 2010 Aug; 18(8):1496-500. PMID: 20502445; PMCID: PMC2927074.
    67. Mehrotra S, Lynam D, Maloney R, Pawelec KM, Tuszynski MH, Lee I, Chan C, Sakamoto J. Time Controlled Protein Release from Layer-by-Layer Assembled Multilayer Functionalized Agarose Hydrogels. Adv Funct Mater. 2010 Jan 22; 20(2):247-258. PMID: 20200599.
      View in: PubMed
    68. Kadoya K, Tsukada S, Lu P, Coppola G, Geschwind D, Filbin MT, Blesch A, Tuszynski MH. Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron. 2009 Oct 29; 64(2):165-72. PMID: 19874785; PMCID: PMC2773653.
    69. Conner JM, Franks KM, Titterness AK, Russell K, Merrill DA, Christie BR, Sejnowski TJ, Tuszynski MH. NGF is essential for hippocampal plasticity and learning. J Neurosci. 2009 Sep 02; 29(35):10883-9. PMID: 19726646; PMCID: PMC2765804.
    70. Alfa RW, Tuszynski MH, Blesch A. A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth. J Neurosci Res. 2009 Sep; 87(12):2624-31. PMID: 19405107; PMCID: PMC2854653.
    71. Alto LT, Havton LA, Conner JM, Hollis ER, Blesch A, Tuszynski MH. Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nat Neurosci. 2009 Sep; 12(9):1106-13. PMID: 19648914; PMCID: PMC2753201.
    72. Ramanathan D, Tuszynski MH, Conner JM. The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity. J Neurosci. 2009 May 06; 29(18):5992-6000. PMID: 19420265.
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    73. Hollis ER, Jamshidi P, Löw K, Blesch A, Tuszynski MH. Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7215-20. PMID: 19359495; PMCID: PMC2678459.
    74. Merrill DA, Masliah E, Roberts JA, McKay H, Kordower JH, Mufson EJ, Tuszynski MH. Association of early experience with neurodegeneration in aged primates. Neurobiol Aging. 2011 Jan; 32(1):151-6. PMID: 19321231; PMCID: PMC4210191.
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    93. Blurton-Jones M, Tuszynski MH. Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF. J Comp Neurol. 2006 Dec 01; 499(4):603-12. PMID: 17029253.
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    96. Lu P, Jones LL, Tuszynski MH. Axon regeneration through scars and into sites of chronic spinal cord injury. Exp Neurol. 2007 Jan; 203(1):8-21. PMID: 17014846.
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    97. Stokols S, Sakamoto J, Breckon C, Holt T, Weiss J, Tuszynski MH. Templated agarose scaffolds support linear axonal regeneration. Tissue Eng. 2006 Oct; 12(10):2777-87. PMID: 17518647.
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    107. Courtine G, Roy RR, Hodgson J, McKay H, Raven J, Zhong H, Yang H, Tuszynski MH, Edgerton VR. Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus). J Neurophysiol. 2005 Jun; 93(6):3127-45. PMID: 15647397.
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    111. Lu P, Yang H, Jones LL, Filbin MT, Tuszynski MH. Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J Neurosci. 2004 Jul 14; 24(28):6402-9. PMID: 15254096.
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    113. Imitola J, Park KI, Teng YD, Nisim S, Lachyankar M, Ourednik J, Mueller FJ, Yiou R, Atala A, Sidman RL, Tuszynski M, Khoury SJ, Snyder EY. Stem cells: cross-talk and developmental programs. Philos Trans R Soc Lond B Biol Sci. 2004 May 29; 359(1445):823-37. PMID: 15293810; PMCID: PMC1693371.
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    115. Nagahara A, Tuszynski MH. The ageless question--what accounts for age-related cognitive decline? Sci Aging Knowledge Environ. 2004 May 12; 2004(19):pe20. PMID: 15141075.
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    116. Smith DE, Rapp PR, McKay HM, Roberts JA, Tuszynski MH. Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J Neurosci. 2004 May 05; 24(18):4373-81. PMID: 15128851.
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    117. Blesch A, Tuszynski MH. Nucleus hears axon's pain. Nat Med. 2004 Mar; 10(3):236-7. PMID: 14991043.
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    119. Blesch A, Tuszynski MH. Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. J Comp Neurol. 2003 Dec 15; 467(3):403-17. PMID: 14608602.
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    120. Jones LL, Sajed D, Tuszynski MH. Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition. J Neurosci. 2003 Oct 15; 23(28):9276-88. PMID: 14561854.
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    121. Jones LL, Margolis RU, Tuszynski MH. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol. 2003 Aug; 182(2):399-411. PMID: 12895450.
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    123. Conner JM, Culberson A, Packowski C, Chiba AA, Tuszynski MH. Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron. 2003 Jun 05; 38(5):819-29. PMID: 12797965.
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    125. Merrill DA, Karim R, Darraq M, Chiba AA, Tuszynski MH. Hippocampal cell genesis does not correlate with spatial learning ability in aged rats. J Comp Neurol. 2003 Apr 28; 459(2):201-7. PMID: 12640670.
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    126. Lacroix S, Chang L, Rose-John S, Tuszynski MH. Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth. J Comp Neurol. 2002 Dec 16; 454(3):213-28. PMID: 12442313.
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    128. Blurton-Jones M, Tuszynski MH. Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats. J Comp Neurol. 2002 Oct 21; 452(3):276-87. PMID: 12353223.
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    134. Jones LL, Yamaguchi Y, Stallcup WB, Tuszynski MH. NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci. 2002 Apr 01; 22(7):2792-803. PMID: 11923444.
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