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Gerald Shadel

Title(s)Adjunct Professor, Molecular Biology
SchoolAcademic Aff
Emailgsshadel@ucsd.edu
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    Collapse Research 
    Collapse Research Activities and Funding
    (PQ5) Mitochondrial Heterogeneity in Melanoma Tumor and Immune Responses
    NIH/NCI R01CA216101Sep 1, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Inducible Mouse Models of Mitochondrial ROS Signaling and Environmental Stress
    NIH/NIEHS R33ES025636Jul 1, 2017 - Jun 30, 2020
    Role: Principal Investigator
    Mitochondrial DNA Stress Activation of Interferon Signaling and Lupus Pathology
    NIH/NIAMS R01AR069876Mar 1, 2017 - May 31, 2022
    Role: Principal Investigator
    INDUCIBLE MOUSE MODELS OF MITOCHONDRIAL ROS SIGNALING AND ENVIRONMENTAL STRESS
    NIH/NIEHS R21ES025636May 1, 2015 - Apr 30, 2017
    Role: Principal Investigator
    Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging
    NIH/NIGMS R13GM106623Jun 11, 2013 - May 31, 2014
    Role: Principal Investigator
    Mitochondrial Dysfunction and Oxidative Stress in Ataxia Telangiectasia
    NIH/NINDS R01NS056206Jun 1, 2007 - May 31, 2013
    Role: Principal Investigator
    Epigenetic Regulation of Mitochondiral Complex II
    NIH/NCI R01CA112364Feb 1, 2005 - Dec 31, 2010
    Role: Principal Investigator
    Nuclear Control of Mitochondrial Gene Expression
    NIH/NIA R01AG047632Sep 30, 1997 - May 31, 2018
    Role: Principal Investigator
    Nuclear Control of Mitochondrial Gene Expression
    NIH/NHLBI R01HL059655Sep 30, 1997 - Jan 31, 2013
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gale M, Li Y, Cao J, Liu ZZ, Holmbeck MA, Zhang M, Lang SM, Wu L, Do Carmo M, Gupta S, Aoshima K, DiGiovanna MP, Stern DF, Rimm DL, Shadel GS, Chen X, Yan Q. Acquired resistance to HER2-targeted therapies creates vulnerability to ATP synthase inhibition. Cancer Res. 2019 Nov 05. PMID: 31690671.
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    2. Harel M, Ortenberg R, Varanasi SK, Mangalhara KC, Mardamshina M, Markovits E, Baruch EN, Tripple V, Arama-Chayoth M, Greenberg E, Shenoy A, Ayasun R, Knafo N, Xu S, Anafi L, Yanovich-Arad G, Barnabas GD, Ashkenazi S, Besser MJ, Schachter J, Bosenberg M, Shadel GS, Barshack I, Kaech SM, Markel G, Geiger T. Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. Cell. 2019 Sep 19; 179(1):236-250.e18. PMID: 31495571.
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    3. Mangalhara KC, Shadel GS. A Mitochondrial-Derived Peptide Exercises the Nuclear Option. Cell Metab. 2018 09 04; 28(3):330-331. PMID: 30184481.
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    4. Newman LE, Shadel GS. Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration. J Cell Biol. 2018 10 01; 217(10):3327-3329. PMID: 30154188.
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    5. Cox CS, McKay SE, Holmbeck MA, Christian BE, Scortea AC, Tsay AJ, Newman LE, Shadel GS. Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling. Cell Metab. 2018 11 06; 28(5):776-786.e5. PMID: 30122556.
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    6. Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q. KDM5 histone demethylases repress immune response via suppression of STING. PLoS Biol. 2018 08; 16(8):e2006134. PMID: 30080846.
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    7. Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS. Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity. Sci Signal. 2018 07 10; 11(538). PMID: 29991649.
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    8. Kuszak AJ, Espey MG, Falk MJ, Holmbeck MA, Manfredi G, Shadel GS, Vernon HJ, Zolkipli-Cunningham Z. Nutritional Interventions for Mitochondrial OXPHOS Deficiencies: Mechanisms and Model Systems. Annu Rev Pathol. 2018 01 24; 13:163-191. PMID: 29099651.
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    9. West AP, Shadel GS. Mitochondrial DNA in innate immune responses and inflammatory pathology. Nat Rev Immunol. 2017 Jun; 17(6):363-375. PMID: 28393922.
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    10. Schweppe DK, Chavez JD, Lee CF, Caudal A, Kruse SE, Stuppard R, Marcinek DJ, Shadel GS, Tian R, Bruce JE. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1732-1737. PMID: 28130547.
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    11. Oran AR, Adams CM, Zhang XY, Gennaro VJ, Pfeiffer HK, Mellert HS, Seidel HE, Mascioli K, Kaplan J, Gaballa MR, Shen C, Rigoutsos I, King MP, Cotney JL, Arnold JJ, Sharma SD, Martinez-Outschoorn UE, Vakoc CR, Chodosh LA, Thompson JE, Bradner JE, Cameron CE, Shadel GS, Eischen CM, McMahon SB. Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget. 2016 Nov 08; 7(45):72395-72414. PMID: 27590350.
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    12. Kang MJ, Shadel GS. A Mitochondrial Perspective of Chronic Obstructive Pulmonary Disease Pathogenesis. Tuberc Respir Dis (Seoul). 2016 Oct; 79(4):207-213. PMID: 27790272.
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    13. Holmbeck MA, Shadel GS. Mitochondria provide a 'complex' solution to a bacterial problem. Nat Immunol. 2016 08 19; 17(9):1009-10. PMID: 27540983.
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    14. Nouws J, Goswami AV, Bestwick M, McCann BJ, Surovtseva YV, Shadel GS. Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import. J Biol Chem. 2016 Jan 08; 291(2):989-97. PMID: 26586915.
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    15. McKay SE, Yan W, Nouws J, Thormann MJ, Raimundo N, Khan A, Santos-Sacchi J, Song L, Shadel GS. Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness. Am J Pathol. 2015 Dec; 185(12):3132-40. PMID: 26552864.
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    16. Shadel GS, Horvath TL. Mitochondrial ROS signaling in organismal homeostasis. Cell. 2015 Oct 22; 163(3):560-9. PMID: 26496603.
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    17. Camell CD, Nguyen KY, Jurczak MJ, Christian BE, Shulman GI, Shadel GS, Dixit VD. Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity. J Biol Chem. 2015 Dec 04; 290(49):29402-13. PMID: 26438821.
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    18. Kang MJ, Yoon CM, Kim BH, Lee CM, Zhou Y, Sauler M, Homer R, Dhamija A, Boffa D, West AP, Shadel GS, Ting JP, Tedrow JR, Kaminski N, Kim WJ, Lee CG, Oh YM, Elias JA. Suppression of NLRX1 in chronic obstructive pulmonary disease. J Clin Invest. 2015 Jun; 125(6):2458-62. PMID: 25938787.
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    19. Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug; 14(4):497-510. PMID: 25902704.
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    20. West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 2015 Apr 23; 520(7548):553-7. PMID: 25642965.
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    21. Thakar J, Mohanty S, West AP, Joshi SR, Ueda I, Wilson J, Meng H, Blevins TP, Tsang S, Trentalange M, Siconolfi B, Park K, Gill TM, Belshe RB, Kaech SM, Shadel GS, Kleinstein SH, Shaw AC. Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. Aging (Albany NY). 2015 Jan; 7(1):38-52. PMID: 25596819.
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    22. Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell. 2014 Dec 18; 159(7):1563-77. PMID: 25525875.
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    23. Clayton DA, Shadel GS. Purification of mitochondria by sucrose step density gradient centrifugation. Cold Spring Harb Protoc. 2014 Oct 01; 2014(10):pdb.prot080028. PMID: 25275106.
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    24. Clayton DA, Shadel GS. Isolation of mitochondria from cells and tissues. Cold Spring Harb Protoc. 2014 Oct 01; 2014(10):pdb.top074542. PMID: 25275115.
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    25. Clayton DA, Shadel GS. Isolation of mitochondria from tissue culture cells. Cold Spring Harb Protoc. 2014 Oct 01; 2014(10):pdb.prot080002. PMID: 25275104.
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    26. Clayton DA, Shadel GS. Isolation of mitochondria from animal tissue. Cold Spring Harb Protoc. 2014 Oct 01; 2014(10):pdb.prot080010. PMID: 25275105.
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    27. Nouws J, Shadel GS. microManaging mitochondrial translation. Cell. 2014 Jul 31; 158(3):477-8. PMID: 25083863.
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    28. Shadel GS. Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging. Microb Cell. 2014 Apr 23; 1(5):140-144. PMID: 28357235.
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    29. Christian BE, Shadel GS. Aging: it's SIRTainly possible to restore mitochondrial dysfunction. Curr Biol. 2014 Mar 03; 24(5):R206-8. PMID: 24602889.
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    30. Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, Lee PJ. MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 01; 306(7):L604-19. PMID: 24487387.
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    31. Schroeder EA, Shadel GS. Crosstalk between mitochondrial stress signals regulates yeast chronological lifespan. Mech Ageing Dev. 2014 Jan; 135:41-9. PMID: 24373996.
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    32. Sharma NK, Lebedeva M, Thomas T, Kovalenko OA, Stumpf JD, Shadel GS, Santos JH. Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia. DNA Repair (Amst). 2014 Jan; 13:22-31. PMID: 24342190.
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    33. Schroeder EA, Raimundo N, Shadel GS. Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metab. 2013 Jun 04; 17(6):954-64. PMID: 23747251.
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    34. Bestwick ML, Shadel GS. Accessorizing the human mitochondrial transcription machinery. Trends Biochem Sci. 2013 Jun; 38(6):283-91. PMID: 23632312.
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    35. Surovtseva YV, Shadel GS. Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis. Nucleic Acids Res. 2013 Feb 01; 41(4):2479-88. PMID: 23303773.
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    36. D'Souza AD, Parish IA, Krause DS, Kaech SM, Shadel GS. Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia. Mol Ther. 2013 Jan; 21(1):42-8. PMID: 23011031.
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    37. Longo VD, Shadel GS, Kaeberlein M, Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab. 2012 Jul 03; 16(1):18-31. PMID: 22768836.
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    38. Ocampo A, Liu J, Schroeder EA, Shadel GS, Barrientos A. Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction. Cell Metab. 2012 Jul 03; 16(1):55-67. PMID: 22768839.
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    39. Lodeiro MF, Uchida A, Bestwick M, Moustafa IM, Arnold JJ, Shadel GS, Cameron CE. Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6513-8. PMID: 22493245.
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    40. Schroeder EA, Shadel GS. Alternative mitochondrial fuel extends life span. Cell Metab. 2012 Apr 04; 15(4):417-8. PMID: 22482723.
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    41. Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS. Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness. Cell. 2012 Feb 17; 148(4):716-26. PMID: 22341444.
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    42. Woo DK, Green PD, Santos JH, D'Souza AD, Walther Z, Martin WD, Christian BE, Chandel NS, Shadel GS. Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. Am J Pathol. 2012 Jan; 180(1):24-31. PMID: 22056359.
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    43. Surovtseva YV, Shutt TE, Cotney J, Cimen H, Chen SY, Koc EC, Shadel GS. Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):17921-6. PMID: 22003127.
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    44. Liu L, Sanosaka M, Lei S, Bestwick ML, Frey JH, Surovtseva YV, Shadel GS, Cooper MP. LRP130 protein remodels mitochondria and stimulates fatty acid oxidation. J Biol Chem. 2011 Dec 02; 286(48):41253-64. PMID: 21971050.
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    45. Malarkey CS, Bestwick M, Kuhlwilm JE, Shadel GS, Churchill ME. Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA. Nucleic Acids Res. 2012 Jan; 40(2):614-24. PMID: 21948790.
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    46. Baysal BE, McKay SE, Kim YJ, Zhang Z, Alila L, Willett-Brozick JE, Pacak K, Kim TH, Shadel GS. Genomic imprinting at a boundary element flanking the SDHD locus. Hum Mol Genet. 2011 Nov 15; 20(22):4452-61. PMID: 21862453.
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    47. Raimundo N, Baysal BE, Shadel GS. Revisiting the TCA cycle: signaling to tumor formation. Trends Mol Med. 2011 Nov; 17(11):641-9. PMID: 21764377.
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    48. Pan Y, Schroeder EA, Ocampo A, Barrientos A, Shadel GS. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab. 2011 Jun 08; 13(6):668-78. PMID: 21641548.
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    49. D'Souza AD, Parish IA, McKay SE, Kaech SM, Shadel GS. Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. Am J Pathol. 2011 Jun; 178(6):2740-51. PMID: 21641396.
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    50. Chatenay-Lapointe M, Shadel GS. Repression of mitochondrial translation, respiration and a metabolic cycle-regulated gene, SLF1, by the yeast Pumilio-family protein Puf3p. PLoS One. 2011; 6(5):e20441. PMID: 21655263.
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    51. West AP, Shadel GS, Ghosh S. Mitochondria in innate immune responses. Nat Rev Immunol. 2011 Jun; 11(6):389-402. PMID: 21597473.
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    52. West AP, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P, Walsh MC, Choi Y, Shadel GS, Ghosh S. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature. 2011 Apr 28; 472(7344):476-80. PMID: 21525932.
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    53. Shutt TE, Bestwick M, Shadel GS. The core human mitochondrial transcription initiation complex: It only takes two to tango. Transcription. 2011 Mar; 2(2):55-59. PMID: 21468229.
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    54. Woo DK, Shadel GS. Mitochondrial stress signals revise an old aging theory. Cell. 2011 Jan 07; 144(1):11-2. PMID: 21215364.
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    55. Chatenay-Lapointe M, Shadel GS. Stressed-out mitochondria get MAD. Cell Metab. 2010 Dec 01; 12(6):559-60. PMID: 21109188.
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    56. Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, Rabinovitch PS, Santos JH, Petersen KF, Samuel VT, Shulman GI. Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab. 2010 Dec 01; 12(6):668-74. PMID: 21109199.
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    57. Shutt TE, Lodeiro MF, Cotney J, Cameron CE, Shadel GS. Core human mitochondrial transcription apparatus is a regulated two-component system in vitro. Proc Natl Acad Sci U S A. 2010 Jul 06; 107(27):12133-8. PMID: 20562347.
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    58. Shutt TE, Shadel GS. A compendium of human mitochondrial gene expression machinery with links to disease. Environ Mol Mutagen. 2010 Jun; 51(5):360-79. PMID: 20544879.
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    59. Shadel GS, Pan Y. Multi-faceted regulation of mitochondria by TOR. Cell Cycle. 2009 Jul 15; 8(14):2143. PMID: 19587547.
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    60. Pawar V, Jingjing L, Patel N, Kaur N, Doetsch PW, Shadel GS, Zhang H, Siede W. Checkpoint kinase phosphorylation in response to endogenous oxidative DNA damage in repair-deficient stationary-phase Saccharomyces cerevisiae. Mech Ageing Dev. 2009 Aug; 130(8):501-8. PMID: 19540258.
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    61. Crouser ED, Shao G, Julian MW, Macre JE, Shadel GS, Tridandapani S, Huang Q, Wewers MD. Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors. Crit Care Med. 2009 Jun; 37(6):2000-9. PMID: 19384205.
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    62. Suissa S, Wang Z, Poole J, Wittkopp S, Feder J, Shutt TE, Wallace DC, Shadel GS, Mishmar D. Ancient mtDNA genetic variants modulate mtDNA transcription and replication. PLoS Genet. 2009 May; 5(5):e1000474. PMID: 19424428.
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    63. Cotney J, McKay SE, Shadel GS. Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness. Hum Mol Genet. 2009 Jul 15; 18(14):2670-82. PMID: 19417006.
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    64. Raimundo N, Shadel GS. A "radical" mitochondrial view of autophagy-related pathology. Aging (Albany NY). 2009 Apr 08; 1(4):354-6. PMID: 20157522.
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    65. Tal MC, Sasai M, Lee HK, Yordy B, Shadel GS, Iwasaki A. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2770-5. PMID: 19196953.
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    66. Pan Y, Shadel GS. Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging (Albany NY). 2009 Jan 28; 1(1):131-45. PMID: 20157595.
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    67. Lebedeva MA, Eaton JS, Shadel GS. Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. Biochim Biophys Acta. 2009 May; 1787(5):328-34. PMID: 19413947.
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    68. Griffiths LM, Doudican NA, Shadel GS, Doetsch PW. Mitochondrial DNA oxidative damage and mutagenesis in Saccharomyces cerevisiae. Methods Mol Biol. 2009; 554:267-86. PMID: 19513680.
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    69. Shadel GS. Into the wild frontier of mitochondrial disease and aging. Methods. 2008 Dec; 46(4):239-40. PMID: 19027636.
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    70. Shadel GS. Debut of MitoMatters. Mitochondrion. 2008 Sep; 8(4):338. PMID: 18775517.
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    71. Bonawitz ND, Chatenay-Lapointe M, Wearn CM, Shadel GS. Expression of the rDNA-encoded mitochondrial protein Tar1p is stringently controlled and responds differentially to mitochondrial respiratory demand and dysfunction. Curr Genet. 2008 Aug; 54(2):83-94. PMID: 18622616.
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    72. Shadel GS. Expression and maintenance of mitochondrial DNA: new insights into human disease pathology. Am J Pathol. 2008 Jun; 172(6):1445-56. PMID: 18458094.
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    73. Schleicher M, Shepherd BR, Suarez Y, Fernandez-Hernando C, Yu J, Pan Y, Acevedo LM, Shadel GS, Sessa WC. Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol. 2008 Jan 14; 180(1):101-12. PMID: 18195103.
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    74. Eaton JS, Lin ZP, Sartorelli AC, Bonawitz ND, Shadel GS. Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J Clin Invest. 2007 Sep; 117(9):2723-34. PMID: 17786248.
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    75. D'Souza AD, Parikh N, Kaech SM, Shadel GS. Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation. Mitochondrion. 2007 Dec; 7(6):374-85. PMID: 17890163.
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    76. Cotney J, Wang Z, Shadel GS. Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression. Nucleic Acids Res. 2007; 35(12):4042-54. PMID: 17557812.
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    77. Lebedeva MA, Shadel GS. Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression. Cell Cycle. 2007 Aug 15; 6(16):2048-57. PMID: 17721079.
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    78. Bonawitz ND, Shadel GS. Rethinking the mitochondrial theory of aging: the role of mitochondrial gene expression in lifespan determination. Cell Cycle. 2007 Jul 01; 6(13):1574-8. PMID: 17603300.
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    79. Bonawitz ND, Chatenay-Lapointe M, Pan Y, Shadel GS. Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab. 2007 Apr; 5(4):265-77. PMID: 17403371.
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    80. Wang Z, Cotney J, Shadel GS. Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. J Biol Chem. 2007 Apr 27; 282(17):12610-8. PMID: 17337445.
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    81. Zhang H, Luo Y, Zhang W, He Y, Dai S, Zhang R, Huang Y, Bernatchez P, Giordano FJ, Shadel G, Sessa WC, Min W. Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. Am J Pathol. 2007 Mar; 170(3):1108-20. PMID: 17322393.
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    82. Shutt TE, Shadel GS. Expanding the mitochondrial interactome. Genome Biol. 2007; 8(2):203. PMID: 17319976.
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    83. Shadel GS, Seidel-Rogol BL. Diagnostic assays for defects in mtDNA replication and transcription in yeast and humans. Methods Cell Biol. 2007; 80:465-79. PMID: 17445709.
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    84. Bonawitz ND, Clayton DA, Shadel GS. Initiation and beyond: multiple functions of the human mitochondrial transcription machinery. Mol Cell. 2006 Dec 28; 24(6):813-25. PMID: 17189185.
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    85. Lin ZP, Belcourt MF, Carbone R, Eaton JS, Penketh PG, Shadel GS, Cory JG, Sartorelli AC. Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress. Biochem Pharmacol. 2007 Mar 15; 73(6):760-72. PMID: 17188250.
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    86. Cotney J, Shadel GS. Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2. J Mol Evol. 2006 Nov; 63(5):707-17. PMID: 17031457.
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    87. Bonawitz ND, Rodeheffer MS, Shadel GS. Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span. Mol Cell Biol. 2006 Jul; 26(13):4818-29. PMID: 16782871.
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    88. O'Rourke TW, Doudican NA, Zhang H, Eaton JS, Doetsch PW, Shadel GS. Differential involvement of the related DNA helicases Pif1p and Rrm3p in mtDNA point mutagenesis and stability. Gene. 2005 Jul 18; 354:86-92. PMID: 15907372.
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    89. Doudican NA, Song B, Shadel GS, Doetsch PW. Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae. Mol Cell Biol. 2005 Jun; 25(12):5196-204. PMID: 15923634.
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    90. Shadel GS. Mitochondrial DNA, aconitase 'wraps' it up. Trends Biochem Sci. 2005 Jun; 30(6):294-6. PMID: 15950872.
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    91. Taylor SD, Zhang H, Eaton JS, Rodeheffer MS, Lebedeva MA, O'rourke TW, Siede W, Shadel GS. The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae. Mol Biol Cell. 2005 Jun; 16(6):3010-8. PMID: 15829566.
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    92. Shadel GS. Coupling the mitochondrial transcription machinery to human disease. Trends Genet. 2004 Oct; 20(10):513-9. PMID: 15363906.
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    93. Shadel GS. A dual-function mitochondrial transcription factor tunes out deafness. Mol Genet Metab. 2004 May; 82(1):1-3. PMID: 15110315.
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    94. McCulloch V, Shadel GS. Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. Mol Cell Biol. 2003 Aug; 23(16):5816-24. PMID: 12897151.
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    95. Rodeheffer MS, Shadel GS. Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis. J Biol Chem. 2003 May 16; 278(20):18695-701. PMID: 12637560.
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    96. Seidel-Rogol BL, McCulloch V, Shadel GS. Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. Nat Genet. 2003 Jan; 33(1):23-4. PMID: 12496758.
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    97. Coelho PS, Bryan AC, Kumar A, Shadel GS, Snyder M. A novel mitochondrial protein, Tar1p, is encoded on the antisense strand of the nuclear 25S rDNA. Genes Dev. 2002 Nov 01; 16(21):2755-60. PMID: 12414727.
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    98. O'Rourke TW, Doudican NA, Mackereth MD, Doetsch PW, Shadel GS. Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins. Mol Cell Biol. 2002 Jun; 22(12):4086-93. PMID: 12024022.
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    99. Seidel-Rogol BL, Shadel GS. Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells. Nucleic Acids Res. 2002 May 01; 30(9):1929-34. PMID: 11972329.
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    100. McCulloch V, Seidel-Rogol BL, Shadel GS. A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. Mol Cell Biol. 2002 Feb; 22(4):1116-25. PMID: 11809803.
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    101. Bryan AC, Rodeheffer MS, Wearn CM, Shadel GS. Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression. Genetics. 2002 Jan; 160(1):75-82. PMID: 11805046.
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    102. Seidel-Rogol BL, Shadel GS. Diagnostic assays for defects in mitochondrial DNA replication and transcription in yeast and human cells. Methods Cell Biol. 2001; 65:413-27. PMID: 11381607.
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    103. Rodeheffer MS, Boone BE, Bryan AC, Shadel GS. Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem. 2001 Mar 16; 276(11):8616-22. PMID: 11118450.
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    104. Shadel GS, Buckenmeyer GA, Clayton DA, Schmitt ME. Mutational analysis of the RNA component of Saccharomyces cerevisiae RNase MRP reveals distinct nuclear phenotypes. Gene. 2000 Mar 07; 245(1):175-84. PMID: 10713458.
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    105. Devine JH, Shadel GS. Assay of autoinducer activity with luminescent Escherichia coli sensor strains harboring a modified Vibrio fischeri lux regulon. Methods Enzymol. 2000; 305:279-87. PMID: 10812607.
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    106. Shadel GS. Yeast as a model for human mtDNA replication. Am J Hum Genet. 1999 Nov; 65(5):1230-7. PMID: 10521287.
      View in: PubMed
    107. Wang Y, Shadel GS. Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):8046-51. PMID: 10393945.
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    108. Shadel GS, Clayton DA. Mitochondrial DNA maintenance in vertebrates. Annu Rev Biochem. 1997; 66:409-35. PMID: 9242913.
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    109. Sitnikov DM, Shadel GS, Baldwin TO. Autoinducer-independent mutants of the LuxR transcriptional activator exhibit differential effects on the two lux promoters of Vibrio fischeri. Mol Gen Genet. 1996 Oct 16; 252(5):622-5. PMID: 8914523.
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    110. Shadel GS, Clayton DA. Mapping promoters in displacement-loop region of vertebrate mitochondrial DNA. Methods Enzymol. 1996; 264:139-48. PMID: 8965688.
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    111. Shadel GS, Clayton DA. Isolation and characterization of vertebrate mitochondrial transcription factor A homologs. Methods Enzymol. 1996; 264:149-58. PMID: 8965689.
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    112. Carrodeguas JA, Yun S, Shadel GS, Clayton DA, Bogenhagen DF. Functional conservation of yeast mtTFB despite extensive sequence divergence. Gene Expr. 1996; 6(4):219-30. PMID: 9196077.
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    113. Dairaghi DJ, Shadel GS, Clayton DA. Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator. J Mol Biol. 1995 May 26; 249(1):11-28. PMID: 7776365.
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    114. Dairaghi DJ, Shadel GS, Clayton DA. Human mitochondrial transcription factor A and promoter spacing integrity are required for transcription initiation. Biochim Biophys Acta. 1995 May 24; 1271(1):127-34. PMID: 7599198.
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    115. Shadel GS, Clayton DA. A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct. Mol Cell Biol. 1995 Apr; 15(4):2101-8. PMID: 7891705.
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    116. Shadel GS, Clayton DA. Mitochondrial transcription initiation. Variation and conservation. J Biol Chem. 1993 Aug 05; 268(22):16083-6. PMID: 8344889.
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    117. Shadel GS, Baldwin TO. Identification of a distantly located regulatory element in the luxD gene required for negative autoregulation of the Vibrio fischeri luxR gene. J Biol Chem. 1992 Apr 15; 267(11):7690-5. PMID: 1560004.
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    118. Shadel GS, Baldwin TO. Positive autoregulation of the Vibrio fischeri luxR gene. LuxR and autoinducer activate cAMP-catabolite gene activator protein complex-independent and -dependent luxR transcription. J Biol Chem. 1992 Apr 15; 267(11):7696-702. PMID: 1373136.
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    119. Shadel GS, Baldwin TO. The Vibrio fischeri LuxR protein is capable of bidirectional stimulation of transcription and both positive and negative regulation of the luxR gene. J Bacteriol. 1991 Jan; 173(2):568-74. PMID: 1987152.
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    120. Shadel GS, Young R, Baldwin TO. Use of regulated cell lysis in a lethal genetic selection in Escherichia coli: identification of the autoinducer-binding region of the LuxR protein from Vibrio fischeri ATCC 7744. J Bacteriol. 1990 Jul; 172(7):3980-7. PMID: 2141835.
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    121. Shadel GS, Devine JH, Baldwin TO. Control of the lux regulon of Vibrio fischeri. J Biolumin Chemilumin. 1990 Apr-Jun; 5(2):99-106. PMID: 2186599.
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    122. Devine JH, Shadel GS, Baldwin TO. Identification of the operator of the lux regulon from the Vibrio fischeri strain ATCC7744. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):5688-92. PMID: 2762291.
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    123. Baldwin TO, Devine JH, Heckel RC, Lin JW, Shadel GS. The complete nucleotide sequence of the lux regulon of Vibrio fischeri and the luxABN region of Photobacterium leiognathi and the mechanism of control of bacterial bioluminescence. J Biolumin Chemilumin. 1989 Jul; 4(1):326-41. PMID: 2801220.
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