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Mark Mayford

Title(s)Adjunct Professor, Neurosciences
SchoolHealth Sciences
Phone858-822-5177
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    Collapse Research 
    Collapse Research Activities and Funding
    Activity Based Taggin of Neurons
    NIH/NIDA R01DA035657Sep 30, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Transgenic Probes of Active Circuits
    NIH/NIDA R01DA028300Sep 1, 2009 - Aug 31, 2014
    Role: Principal Investigator
    CBP Acetyltransferase Function in Addictive Behavior
    NIH/NIDA R03DA022268Sep 25, 2006 - Aug 31, 2008
    Role: Principal Investigator
    Anatomical Tracing of Activated Brain Circuits
    NIH/NIMH R21MH070020Dec 1, 2003 - Nov 30, 2007
    Role: Principal Investigator
    Genetic Screen For Oxidative Resistance in Mice
    NIH/NIA R03AG020377Feb 1, 2002 - Jan 31, 2003
    Role: Principal Investigator
    Regulated Genetics Studies of Memory Formation
    NIH/NIMH R01MH057368Jul 1, 1997 - Jan 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. de Sousa AF, Cowansage KK, Zutshi I, Cardozo LM, Yoo EJ, Leutgeb S, Mayford M. Optogenetic reactivation of memory ensembles in the retrosplenial cortex induces systems consolidation. Proc Natl Acad Sci U S A. 2019 Apr 23; 116(17):8576-8581. PMID: 30877252.
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    2. Corches A, Hiroto A, Bailey TW, Speigel JH, Pastore J, Mayford M, Korzus E. Differential fear conditioning generates prefrontal neural ensembles of safety signals. Behav Brain Res. 2019 03 15; 360:169-184. PMID: 30502356.
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    3. Groves A, Kihara Y, Jonnalagadda D, Rivera R, Kennedy G, Mayford M, Chun J. A Functionally Defined In Vivo Astrocyte Population Identified by c-Fos Activation in a Mouse Model of Multiple Sclerosis Modulated by S1P Signaling: Immediate-Early Astrocytes (ieAstrocytes). eNeuro. 2018 Sep-Oct; 5(5). PMID: 30255127.
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    4. Suto N, Laque A, De Ness GL, Wagner GE, Watry D, Kerr T, Koya E, Mayford MR, Hope BT, Weiss F. Distinct memory engrams in the infralimbic cortex of rats control opposing environmental actions on a learned behavior. Elife. 2016 12 10; 5. PMID: 27938664.
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    5. Sanders J, Mayford M. Chronic fluoxetine dissociates contextual from auditory fear memory. Neurosci Lett. 2016 Oct 06; 632:152-6. PMID: 27592057.
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    6. Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time. Nature. 2016 06 02; 534(7605):115-8. PMID: 27251287.
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    7. Mayford M, Reijmers L. Exploring Memory Representations with Activity-Based Genetics. Cold Spring Harb Perspect Biol. 2015 Dec 18; 8(3):a021832. PMID: 26684182.
      View in: PubMed
    8. Ben-Yakov A, Dudai Y, Mayford MR. Memory Retrieval in Mice and Men. Cold Spring Harb Perspect Biol. 2015 Oct 05; 7(12). PMID: 26438596.
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    9. Drane L, Ainsley JA, Mayford MR, Reijmers LG. A transgenic mouse line for collecting ribosome-bound mRNA using the tetracycline transactivator system. Front Mol Neurosci. 2014; 7:82. PMID: 25400545.
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    10. Cowansage KK, Shuman T, Dillingham BC, Chang A, Golshani P, Mayford M. Direct reactivation of a coherent neocortical memory of context. Neuron. 2014 Oct 22; 84(2):432-41. PMID: 25308330.
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    11. Kandel ER, Dudai Y, Mayford MR. The molecular and systems biology of memory. Cell. 2014 Mar 27; 157(1):163-86. PMID: 24679534.
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    12. Mayford M. The search for a hippocampal engram. Philos Trans R Soc Lond B Biol Sci. 2014 Jan 05; 369(1633):20130161. PMID: 24298162.
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    13. Sando R, Baumgaertel K, Pieraut S, Torabi-Rander N, Wandless TJ, Mayford M, Maximov A. Inducible control of gene expression with destabilized Cre. Nat Methods. 2013 Nov; 10(11):1085-8. PMID: 24056874.
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    14. Sanders J, Mayford M, Jeste D. Empathic fear responses in mice are triggered by recognition of a shared experience. PLoS One. 2013; 8(9):e74609. PMID: 24058601.
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    15. Rowland DC, Weible AP, Wickersham IR, Wu H, Mayford M, Witter MP, Kentros CG. Transgenically targeted rabies virus demonstrates a major monosynaptic projection from hippocampal area CA2 to medial entorhinal layer II neurons. J Neurosci. 2013 Sep 11; 33(37):14889-98. PMID: 24027288.
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    16. Deng W, Mayford M, Gage FH. Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice. Elife. 2013 Mar 20; 2:e00312. PMID: 23538967.
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    17. Sanders J, Cowansage K, Baumgärtel K, Mayford M. Elimination of dendritic spines with long-term memory is specific to active circuits. J Neurosci. 2012 Sep 05; 32(36):12570-8. PMID: 22956846.
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    18. Garner A, Mayford M. New approaches to neural circuits in behavior. Learn Mem. 2012 Aug 16; 19(9):385-90. PMID: 22904369.
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    19. Mayford M. Navigating uncertain waters. Nat Neurosci. 2012 Jul 26; 15(8):1056-7. PMID: 22837031.
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    20. Mayford M, Siegelbaum SA, Kandel ER. Synapses and memory storage. Cold Spring Harb Perspect Biol. 2012 Jun 01; 4(6). PMID: 22496389.
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    21. Kourrich S, Klug JR, Mayford M, Thomas MJ. AMPAR-independent effect of striatal aCaMKII promotes the sensitization of cocaine reward. J Neurosci. 2012 May 09; 32(19):6578-86. PMID: 22573680.
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    22. Garner AR, Rowland DC, Hwang SY, Baumgaertel K, Roth BL, Kentros C, Mayford M. Generation of a synthetic memory trace. Science. 2012 Mar 23; 335(6075):1513-6. PMID: 22442487.
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    23. Takahashi N, Kitamura K, Matsuo N, Mayford M, Kano M, Matsuki N, Ikegaya Y. Locally synchronized synaptic inputs. Science. 2012 Jan 20; 335(6066):353-6. PMID: 22267814.
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    24. Tayler KK, Lowry E, Tanaka K, Levy B, Reijmers L, Mayford M, Wiltgen BJ. Characterization of NMDAR-Independent Learning in the Hippocampus. Front Behav Neurosci. 2011; 5:28. PMID: 21629769.
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    25. Bibb JA, Mayford MR, Tsien JZ, Alberini CM. Cognition enhancement strategies. J Neurosci. 2010 Nov 10; 30(45):14987-92. PMID: 21068302.
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    26. Reijmers L, Mayford M. Genetic control of active neural circuits. Front Mol Neurosci. 2009; 2:27. PMID: 20057936.
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    27. Barros CS, Calabrese B, Chamero P, Roberts AJ, Korzus E, Lloyd K, Stowers L, Mayford M, Halpain S, Müller U. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4507-12. PMID: 19240213.
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    28. Matsuo N, Reijmers L, Mayford M. Spine-type-specific recruitment of newly synthesized AMPA receptors with learning. Science. 2008 Feb 22; 319(5866):1104-7. PMID: 18292343.
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    29. Reijmers LG, Perkins BL, Matsuo N, Mayford M. Localization of a stable neural correlate of associative memory. Science. 2007 Aug 31; 317(5842):1230-3. PMID: 17761885.
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    30. Li KW, Miller S, Klychnikov O, Loos M, Stahl-Zeng J, Spijker S, Mayford M, Smit AB. Quantitative proteomics and protein network analysis of hippocampal synapses of CaMKIIalpha mutant mice. J Proteome Res. 2007 Aug; 6(8):3127-33. PMID: 17625814.
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    31. Mayford M. Protein kinase signaling in synaptic plasticity and memory. Curr Opin Neurobiol. 2007 Jun; 17(3):313-7. PMID: 17499495.
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    32. Nagaoka-Yasuda R, Matsuo N, Perkins B, Limbaeck-Stokin K, Mayford M. An RNAi-based genetic screen for oxidative stress resistance reveals retinol saturase as a mediator of stress resistance. Free Radic Biol Med. 2007 Sep 01; 43(5):781-8. PMID: 17664141.
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    33. Wiltgen BJ, Law M, Ostlund S, Mayford M, Balleine BW. The influence of Pavlovian cues on instrumental performance is mediated by CaMKII activity in the striatum. Eur J Neurosci. 2007 Apr; 25(8):2491-7. PMID: 17445244.
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    34. Yasuda M, Mayford MR. CaMKII activation in the entorhinal cortex disrupts previously encoded spatial memory. Neuron. 2006 Apr 20; 50(2):309-18. PMID: 16630840.
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    35. Reijmers LG, Coats JK, Pletcher MT, Wiltshire T, Tarantino LM, Mayford M. A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Learn Mem. 2006 Mar-Apr; 13(2):143-9. PMID: 16585790.
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    36. Colvis CM, Pollock JD, Goodman RH, Impey S, Dunn J, Mandel G, Champagne FA, Mayford M, Korzus E, Kumar A, Renthal W, Theobald DE, Nestler EJ. Epigenetic mechanisms and gene networks in the nervous system. J Neurosci. 2005 Nov 09; 25(45):10379-89. PMID: 16280577.
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    37. Limbäck-Stokin K, Korzus E, Nagaoka-Yasuda R, Mayford M. Nuclear calcium/calmodulin regulates memory consolidation. J Neurosci. 2004 Dec 01; 24(48):10858-67. PMID: 15574736.
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    38. Korzus E, Rosenfeld MG, Mayford M. CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron. 2004 Jun 24; 42(6):961-72. PMID: 15207240.
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    39. Miller S, Yasuda M, Coats JK, Jones Y, Martone ME, Mayford M. Disruption of dendritic translation of CaMKIIalpha impairs stabilization of synaptic plasticity and memory consolidation. Neuron. 2002 Oct 24; 36(3):507-19. PMID: 12408852.
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    40. Bejar R, Yasuda R, Krugers H, Hood K, Mayford M. Transgenic calmodulin-dependent protein kinase II activation: dose-dependent effects on synaptic plasticity, learning, and memory. J Neurosci. 2002 Jul 01; 22(13):5719-26. PMID: 12097524.
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    41. Glazewski S, Bejar R, Mayford M, Fox K. The effect of autonomous alpha-CaMKII expression on sensory responses and experience-dependent plasticity in mouse barrel cortex. Neuropharmacology. 2001 Nov; 41(6):771-8. PMID: 11640932.
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    42. Krestel HE, Mayford M, Seeburg PH, Sprengel R. A GFP-equipped bidirectional expression module well suited for monitoring tetracycline-regulated gene expression in mouse. Nucleic Acids Res. 2001 Apr 01; 29(7):E39. PMID: 11266574.
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    43. Lumsden A, Chapman S, Schubert F, Toole L, Mayford M, Hamann S, Reber PJ, Häusser M, Murthy VN, Wood JN, Liman ER, Filbin MT, Qiu J, Ashe J, Chafee M, Goodwin S, Kyriacou B, Kempermann G, Winkler J. Neurobiology. Curr Opin Neurobiol. 2001 Feb; 11(1):1-9. PMID: 11179863.
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    44. Sandberg R, Yasuda R, Pankratz DG, Carter TA, Del Rio JA, Wodicka L, Mayford M, Lockhart DJ, Barlow C. Regional and strain-specific gene expression mapping in the adult mouse brain. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):11038-43. PMID: 11005875.
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    45. Wiedenmayer CP, Myers MM, Mayford M, Barr GA. Olfactory based spatial learning in neonatal mice and its dependence on CaMKII. Neuroreport. 2000 Apr 07; 11(5):1051-5. PMID: 10790881.
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    46. Mayford M, Kandel ER. Genetic approaches to memory storage. Trends Genet. 1999 Nov; 15(11):463-70. PMID: 10529810.
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    47. Miller S, Mayford M. Cellular and molecular mechanisms of memory: the LTP connection. Curr Opin Genet Dev. 1999 Jun; 9(3):333-7. PMID: 10377283.
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    48. Mansuy IM, Winder DG, Moallem TM, Osman M, Mayford M, Hawkins RD, Kandel ER. Inducible and reversible gene expression with the rtTA system for the study of memory. Neuron. 1998 Aug; 21(2):257-65. PMID: 9728905.
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    49. Mansuy IM, Mayford M, Jacob B, Kandel ER, Bach ME. Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell. 1998 Jan 09; 92(1):39-49. PMID: 9489698.
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    50. Mayford M, Mansuy IM, Muller RU, Kandel ER. Memory and behavior: a second generation of genetically modified mice. Curr Biol. 1997 Sep 01; 7(9):R580-9. PMID: 9285710.
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    51. Kojima N, Wang J, Mansuy IM, Grant SG, Mayford M, Kandel ER. Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4761-5. PMID: 9114065.
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    52. Rotenberg A, Mayford M, Hawkins RD, Kandel ER, Muller RU. Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus. Cell. 1996 Dec 27; 87(7):1351-61. PMID: 8980240.
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    53. Tsien JZ, Chen DF, Gerber D, Tom C, Mercer EH, Anderson DJ, Mayford M, Kandel ER, Tonegawa S. Subregion- and cell type-restricted gene knockout in mouse brain. Cell. 1996 Dec 27; 87(7):1317-26. PMID: 8980237.
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    54. Mayford M, Bach ME, Huang YY, Wang L, Hawkins RD, Kandel ER. Control of memory formation through regulated expression of a CaMKII transgene. Science. 1996 Dec 06; 274(5293):1678-83. PMID: 8939850.
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    55. Mayford M, Baranes D, Podsypanina K, Kandel ER. The 3'-untranslated region of CaMKII alpha is a cis-acting signal for the localization and translation of mRNA in dendrites. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13250-5. PMID: 8917577.
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    56. Mayford M, Bach ME, Kandel E. CaMKII function in the nervous system explored from a genetic perspective. Cold Spring Harb Symp Quant Biol. 1996; 61:219-24. PMID: 9246450.
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    57. Mayford M, Wang J, Kandel ER, O'Dell TJ. CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell. 1995 Jun 16; 81(6):891-904. PMID: 7781066.
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    58. Bach ME, Hawkins RD, Osman M, Kandel ER, Mayford M. Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell. 1995 Jun 16; 81(6):905-15. PMID: 7781067.
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    59. Mayford M, Abel T, Kandel ER. Transgenic approaches to cognition. Curr Opin Neurobiol. 1995 Apr; 5(2):141-8. PMID: 7620300.
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    60. Mayford M, Barzilai A, Keller F, Schacher S, Kandel ER. Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia. Science. 1992 May 01; 256(5057):638-44. PMID: 1585176.
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    61. Mayford M, Weisblum B. The ermC leader peptide: amino acid alterations leading to differential efficiency of induction by macrolide-lincosamide-streptogramin B antibiotics. J Bacteriol. 1990 Jul; 172(7):3772-9. PMID: 2113911.
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    62. Schacher S, Glanzman D, Barzilai A, Dash P, Grant SG, Keller F, Mayford M, Kandel ER. Long-term facilitation in Aplysia: persistent phosphorylation and structural changes. Cold Spring Harb Symp Quant Biol. 1990; 55:187-202. PMID: 1966763.
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    63. Mayford M, Weisblum B. Conformational alterations in the ermC transcript in vivo during induction. EMBO J. 1989 Dec 20; 8(13):4307-14. PMID: 2480236.
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    64. Mayford M, Weisblum B. ermC leader peptide. Amino acid sequence critical for induction by translational attenuation. J Mol Biol. 1989 Mar 05; 206(1):69-79. PMID: 2467989.
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    65. Mayford M, Weisblum B. Messenger RNA from Staphylococcus aureus that specifies macrolide-lincosamide-streptogramin resistance. Demonstration of its conformations and of the leader peptide it encodes. J Mol Biol. 1985 Oct 20; 185(4):769-80. PMID: 2414456.
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