Subhojit Roy

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    A static cell is a dead cell. Our broad interest is to explore movement in neurons – mechanisms that convey, deposit, and retain cargoes in axons, dendrites and synapses. A related interest is to manipulate trafficking-pathways for therapeutics in neurodegenerative diseases (particularly gene- and CRISPR- based therapies).
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    Pathophysiologic roles of alpha-synuclein at the synapse
    NIH R01NS111978Aug 15, 2019 - May 31, 2024
    Role: Principal Investigator
    Enabling Nanoplatforms for Targeted in vivo Delivery of CRISPR/Cas9 Ribonucleoproteins in the Brain
    NIH UH3NS111688Sep 30, 2018 - Jul 31, 2023
    Role: Co-Principal Investigator
    Enabling Nanoplatforms for Targeted in vivo Delivery of CRISPR/Cas9 Ribonucleoproteins in the Brain
    NIH UG3NS111688Sep 30, 2018 - Jul 31, 2021
    Role: Co-Principal Investigator
    A CRISPR-Cas9 screen to identify genetic modifiers of APP/BACE-1 interactions
    NIH R21AG052404Jul 15, 2016 - Mar 31, 2020
    Role: Principal Investigator
    Trafficking and Endosomal Sorting of APP and BACE-1
    NIH R01AG048218Sep 1, 2014 - Apr 30, 2021
    Role: Principal Investigator
    Molecular determinants and function of axonal actin assemblies
    NIH R01NS075233Jan 15, 2012 - May 31, 2024
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Long term rescue of Alzheimer's deficits in vivo by one-time gene-editing of App C-terminus. bioRxiv. 2024 Jun 09. Aulston BD, Gimse K, Bazick HO, Kramar EA, Pizzo DP, Parra-Rivas LA, Sun J, Branes-Guerrero K, Checka N, Bagheri N, Satyadev N, Carlson-Stevermer J, Saito T, Saido TC, Audhya A, Wood MA, Zylka MJ, Saha K, Roy S. PMID: 38895278; PMCID: PMC11185791.
      View in: PubMed   Mentions:
    2. Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration. J Neurosci. 2023 05 24; 43(21):3970-3984. Lawrence JA, Aguilar-Calvo P, Ojeda-Juárez D, Khuu H, Soldau K, Pizzo DP, Wang J, Malik A, Shay TF, Sullivan EE, Aulston B, Song SM, Callender JA, Sanchez H, Geschwind MD, Roy S, Rissman RA, Trejo J, Tanaka N, Wu C, Chen X, Patrick GN, Sigurdson CJ. PMID: 37019623; PMCID: PMC10219035.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain. 2022 04 29; 145(3):879-886. Steinkellner T, Conrad WS, Kovacs I, Rissman RA, Lee EB, Trojanowski JQ, Freyberg Z, Roy S, Luk KC, Lee VM, Hnasko TS. PMID: 35258081; PMCID: PMC9050538.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    4. Clathrin packets move in slow axonal transport and deliver functional payloads to synapses. Neuron. 2021 09 15; 109(18):2884-2901.e7. Ganguly A, Sharma R, Boyer NP, Wernert F, Phan S, Boassa D, Parra L, Das U, Caillol G, Han X, Yates JR, Ellisman MH, Leterrier C, Roy S. PMID: 34534453; PMCID: PMC8457040.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    5. The NIH Somatic Cell Genome Editing program. Nature. 2021 04; 592(7853):195-204. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J, SCGE Consortium. PMID: 33828315; PMCID: PMC8026397.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    6. Gene-based therapies for neurodegenerative diseases. Nat Neurosci. 2021 03; 24(3):297-311. Sun J, Roy S. PMID: 33526943; PMCID: PMC8394447.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    7. Finding order in slow axonal transport. Curr Opin Neurobiol. 2020 08; 63:87-94. Roy S. PMID: 32361600; PMCID: PMC7483916.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    8. Synapsins regulate α-synuclein functions. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11116-11118. Atias M, Tevet Y, Sun J, Stavsky A, Tal S, Kahn J, Roy S, Gitler D. PMID: 31110014; PMCID: PMC6561288.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    9. Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11113-11115. Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. PMID: 31110017; PMCID: PMC6561242.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    10. Proteomic Atlas of the Human Brain in Alzheimer's Disease. J Proteome Res. 2019 03 01; 18(3):1380-1391. McKetney J, Runde RM, Hebert AS, Salamat S, Roy S, Coon JJ. PMID: 30735395; PMCID: PMC6480317.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    11. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019 01 03; 10(1):53. Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. PMID: 30604771; PMCID: PMC6318289.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    12. Processive flow by biased polymerization mediates the slow axonal transport of actin. J Cell Biol. 2019 01 07; 218(1):112-124. Chakrabarty N, Dubey P, Tang Y, Ganguly A, Ladt K, Leterrier C, Jung P, Roy S. PMID: 30401699; PMCID: PMC6314539.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    13. Actin Assemblies in the Axon Shaft - some Open Questions. Curr Opin Neurobiol. 2018 08; 51:163-167. Dubey P, Jorgenson K, Roy S. PMID: 30005298; PMCID: PMC7338041.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis. Dev Neurobiol. 2018 03; 78(3):340-347. Sun J, Roy S. PMID: 29106038; PMCID: PMC7336871.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    15. The nano-architecture of the axonal cytoskeleton. Nat Rev Neurosci. 2017 12; 18(12):713-726. Leterrier C, Dubey P, Roy S. PMID: 29097785.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    16. Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease. Nat Neurosci. 2017 10 26; 20(11):1514-1515. Roy S. PMID: 29073642.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    17. Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory. J Neurosci. 2017 07 19; 37(29):6926-6937. Palmeri A, Ricciarelli R, Gulisano W, Rivera D, Rebosio C, Calcagno E, Tropea MR, Conti S, Das U, Roy S, Pronzato MA, Arancio O, Fedele E, Puzzo D. PMID: 28626017; PMCID: PMC5518421.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    18. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 07 03; 216(7):2059-2074. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR, Roy S. PMID: 28559423; PMCID: PMC5496608.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    19. Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. J Neurosci. 2017 02 15; 37(7):1675-1684. Adamowicz DH, Roy S, Salmon DP, Galasko DR, Hansen LA, Masliah E, Gage FH. PMID: 28039370; PMCID: PMC5320602.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    20. Dynein's Life in the Slow Lane. Neuron. 2016 06 01; 90(5):907-9. Roy S. PMID: 27253442.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    21. Waves, rings, and trails: The scenic landscape of axonal actin. J Cell Biol. 2016 Jan 18; 212(2):131-4. Roy S. PMID: 26754647; PMCID: PMC4738387.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    22. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan; 19(1):55-64. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. PMID: 26642089; PMCID: PMC4782935.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    23. Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease. JAMA Neurol. 2015 Oct; 72(10):1139-47. Tuszynski MH, Yang JH, Barba D, U HS, Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, Nagahara AH. PMID: 26302439; PMCID: PMC4944824.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCellsCTClinical Trials
    24. Axonal actin in action: Imaging actin dynamics in neurons. Methods Cell Biol. 2016; 131:91-106. Ladt K, Ganguly A, Roy S. PMID: 26794509; PMCID: PMC7336870.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. A dynamic formin-dependent deep F-actin network in axons. J Cell Biol. 2015 Aug 03; 210(3):401-17. Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent B, Leterrier C, Roy S. PMID: 26216902; PMCID: PMC4523607.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    26. α-synuclein multimers cluster synaptic vesicles and attenuate recycling. Curr Biol. 2014 Oct 06; 24(19):2319-26. Wang L, Das U, Scott DA, Tang Y, McLean PJ, Roy S. PMID: 25264250; PMCID: PMC4190006.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    27. Patches of disorganization in the neocortex of children with autism. N Engl J Med. 2014 Mar 27; 370(13):1209-1219. Stoner R, Chow ML, Boyle MP, Sunkin SM, Mouton PR, Roy S, Wynshaw-Boris A, Colamarino SA, Lein ES, Courchesne E. PMID: 24670167; PMCID: PMC4499461.
      View in: PubMed   Mentions: 340     Fields:    Translation:HumansCells
    28. Using photoactivatable GFP to track axonal transport kinetics. Methods Mol Biol. 2014; 1148:203-15. Ganguly A, Roy S. PMID: 24718803.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    29. Fast vesicle transport is required for the slow axonal transport of synapsin. J Neurosci. 2013 Sep 25; 33(39):15362-75. Tang Y, Scott D, Das U, Gitler D, Ganguly A, Roy S. PMID: 24068803; PMCID: PMC3782618.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    30. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 07; 79(3):447-60. Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. PMID: 23931995; PMCID: PMC3741682.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    31. Seeing the unseen: the hidden world of slow axonal transport. Neuroscientist. 2014 Feb; 20(1):71-81. Roy S. PMID: 23912032; PMCID: PMC3902140.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    32. α-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis. J Neurosci. 2012 Jul 25; 32(30):10129-35. Scott D, Roy S. PMID: 22836248; PMCID: PMC3426499.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    33. The slow axonal transport of alpha-synuclein--mechanistic commonalities amongst diverse cytosolic cargoes. Cytoskeleton (Hoboken). 2012 Jul; 69(7):506-13. Tang Y, Das U, Scott DA, Roy S. PMID: 22344896; PMCID: PMC3376189.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    34. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers. Traffic. 2012 May; 13(5):681-93. Tang Y, Scott DA, Das U, Edland SD, Radomski K, Koo EH, Roy S. PMID: 22309053; PMCID: PMC3593673.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    35. A simple photoactivation and image analysis module for visualizing and analyzing axonal transport with high temporal resolution. Nat Protoc. 2011 Dec 15; 7(1):62-8. Roy S, Yang G, Tang Y, Scott DA. PMID: 22179592; PMCID: PMC3568933.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    36. Simulated brain biopsy for diagnosing neurodegeneration using autopsy-confirmed cases. Acta Neuropathol. 2011 Dec; 122(6):737-45. Venneti S, Robinson JL, Roy S, White MT, Baccon J, Xie SX, Trojanowski JQ. PMID: 21959586; PMCID: PMC3575084.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    37. Mechanistic logic underlying the axonal transport of cytosolic proteins. Neuron. 2011 May 12; 70(3):441-54. Scott DA, Das U, Tang Y, Roy S. PMID: 21555071; PMCID: PMC3096075.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    38. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci. 2010 Jun 16; 30(24):8083-95. Scott DA, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. PMID: 20554859; PMCID: PMC2901533.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansAnimalsCells
    39. Successful treatment of the murine model of cystinosis using bone marrow cell transplantation. Blood. 2009 Sep 17; 114(12):2542-52. Syres K, Harrison F, Tadlock M, Jester JV, Simpson J, Roy S, Salomon DR, Cherqui S. PMID: 19506297.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    40. A case study of an emerging visual artist with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Neurocase. 2009 Jun; 15(3):235-47. Liu A, Werner K, Roy S, Trojanowski JQ, Morgan-Kane U, Miller BL, Rankin KP. PMID: 19274573; PMCID: PMC2829114.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    41. The paradoxical cell biology of alpha-Synucle. Results Probl Cell Differ. 2009; 48:159-72. Roy S. PMID: 19582404.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    42. Cytoskeletal requirements in axonal transport of slow component-b. J Neurosci. 2008 May 14; 28(20):5248-56. Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. PMID: 18480281; PMCID: PMC2648304.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    43. Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Mol Biol Cell. 2008 Mar; 19(3):1093-103. Soper JH, Roy S, Stieber A, Lee E, Wilson RB, Trojanowski JQ, Burd CG, Lee VM. PMID: 18172022; PMCID: PMC2262993.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    44. Rapid and intermittent cotransport of slow component-b proteins. J Neurosci. 2007 Mar 21; 27(12):3131-8. Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. PMID: 17376974; PMCID: PMC6672457.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    45. Survival and invasiveness of astrocytomas promoted by erythropoietin. J Neurosurg. 2007 Feb; 106(2):338-50. Mohyeldin A, Dalgard CL, Lu H, Mcfate T, Tait AS, Patel VC, Wong K, Rushing E, Roy S, Acs G, Verma A. PMID: 17410721.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    46. Actinomycotic brain infection: registered diffusion, perfusion MR imaging and MR spectroscopy. Neuroradiology. 2006 May; 48(5):346-50. Wang S, Wolf RL, Woo JH, Wang J, O'Rourke DM, Roy S, Melhem ER, Poptani H. PMID: 16614822.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    47. Seizures, frontal lobe mass, and remote history of periodontal abscess. Arch Pathol Lab Med. 2005 Jun; 129(6):805-6. Roy S, Ellenbogen JM. PMID: 15913436.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    48. D2-40, a novel monoclonal antibody against the M2A antigen as a marker to distinguish hemangioblastomas from renal cell carcinomas. Acta Neuropathol. 2005 May; 109(5):497-502. Roy S, Chu A, Trojanowski JQ, Zhang PJ. PMID: 15864611.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    49. Transport of neurofilaments in growing axons requires microtubules but not actin filaments. J Neurosci Res. 2005 Feb 15; 79(4):442-50. Francis F, Roy S, Brady ST, Black MM. PMID: 15635594.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    50. Axonal transport defects: a common theme in neurodegenerative diseases. Acta Neuropathol. 2005 Jan; 109(1):5-13. Roy S, Zhang B, Lee VM, Trojanowski JQ. PMID: 15645263.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimals
    51. Pathologic quiz case: a 49-year-old woman with an adrenal mass. Pancreatic tissue with nesidiodysplasia, adrenocortical adenoma, and ovarian thecal metaplasia in the adrenal gland. Arch Pathol Lab Med. 2004 Nov; 128(11):1294-6. Giorgadze TA, Roy S, Fraker DL, Brooks JS, Livolsi VA. PMID: 15504068.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
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