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Subhojit Roy

Title(s)Professor, Pathology
SchoolHealth Sciences
Address9500 Gilman Drive #0626
La Jolla CA 92093
Phone858-246-5419
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    Pathophysiologic roles of alpha-synuclein at the synapse
    NIH/NINDS R01NS111978Aug 15, 2019 - May 31, 2024
    Role: Principal Investigator
    Enabling Nanoplatforms for Targeted in vivo Delivery of CRISPR/Cas9 Ribonucleoproteins in the Brain
    NIH/NINDS UG3NS111688Sep 30, 2018 - Jul 31, 2021
    Role: Co-Principal Investigator
    Trafficking and Endosomal Sorting of APP and BACE-1
    NIH/NIA R01AG048218Aug 11, 2016 - Apr 30, 2019
    Role: Principal Investigator
    A CRISPR-Cas9 screen to identify genetic modifiers of APP/BACE-1 interactions
    NIH/NIA R21AG052404Jul 15, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Slow axonal transport of cytosolic cargoes by dynamic-recruitment - a new traffic
    NIH/NINDS R01NS075233Jan 15, 2012 - May 31, 2024
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Finding order in slow axonal transport. Curr Opin Neurobiol. 2020 Apr 30; 63:87-94. Roy S. PMID: 32361600.
      View in: PubMed   Mentions:    Fields:    
    2. Synapsins regulate a-synuclein functions. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11116-11118. Atias M, Tevet Y, Sun J, Stavsky A, Tal S, Kahn J, Roy S, Gitler D. PMID: 31110014.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    3. Functional cooperation of a-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11113-11115. Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. PMID: 31110017.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    4. CRISPR/Cas9 editing of APP C-terminus attenuates ß-cleavage and promotes a-cleavage. Nat Commun. 2019 01 03; 10(1):53. Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. PMID: 30604771.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Processive flow by biased polymerization mediates the slow axonal transport of actin. J Cell Biol. 2019 01 07; 218(1):112-124. Chakrabarty N, Dubey P, Tang Y, Ganguly A, Ladt K, Leterrier C, Jung P, Roy S. PMID: 30401699.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Actin Assemblies in the Axon Shaft - some Open Questions. Curr Opin Neurobiol. 2018 08; 51:163-167. Dubey P, Jorgenson K, Roy S. PMID: 30005298.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Author Correction: Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease. Nat Neurosci. 2018 Jul; 21(7):1015. Roy S. PMID: 29263407.
      View in: PubMed   Mentions:    Fields:    
    8. The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis. Dev Neurobiol. 2018 03; 78(3):340-347. Sun J, Roy S. PMID: 29106038.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    9. The nano-architecture of the axonal cytoskeleton. Nat Rev Neurosci. 2017 12; 18(12):713-726. Leterrier C, Dubey P, Roy S. PMID: 29097785.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease. Nat Neurosci. 2017 10 26; 20(11):1514-1515. Roy S. PMID: 29073642.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Amyloid-ß Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory. J Neurosci. 2017 07 19; 37(29):6926-6937. Palmeri A, Ricciarelli R, Gulisano W, Rivera D, Rebosio C, Calcagno E, Tropea MR, Conti S, Das U, Roy S, Pronzato MA, Arancio O, Fedele E, Puzzo D. PMID: 28626017.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    12. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 07 03; 216(7):2059-2074. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR, Roy S. PMID: 28559423.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Hippocampal a-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. J Neurosci. 2017 02 15; 37(7):1675-1684. Adamowicz DH, Roy S, Salmon DP, Galasko DR, Hansen LA, Masliah E, Gage FH. PMID: 28039370.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    14. Dynein's Life in the Slow Lane. Neuron. 2016 06 01; 90(5):907-9. Roy S. PMID: 27253442.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    15. Waves, rings, and trails: The scenic landscape of axonal actin. J Cell Biol. 2016 Jan 18; 212(2):131-4. Roy S. PMID: 26754647.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    16. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan; 19(1):55-64. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. PMID: 26642089.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    17. Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease. JAMA Neurol. 2015 Oct; 72(10):1139-47. Tuszynski MH, Yang JH, Barba D, U HS, Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, Nagahara AH. PMID: 26302439.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCellsCTClinical Trials
    18. Axonal actin in action: Imaging actin dynamics in neurons. Methods Cell Biol. 2016; 131:91-106. Ladt K, Ganguly A, Roy S. PMID: 26794509.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    19. A dynamic formin-dependent deep F-actin network in axons. J Cell Biol. 2015 Aug 03; 210(3):401-17. Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent B, Leterrier C, Roy S. PMID: 26216902.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    20. a-synuclein multimers cluster synaptic vesicles and attenuate recycling. Curr Biol. 2014 Oct 06; 24(19):2319-26. Wang L, Das U, Scott DA, Tang Y, McLean PJ, Roy S. PMID: 25264250.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    21. Patches of disorganization in the neocortex of children with autism. N Engl J Med. 2014 Mar 27; 370(13):1209-1219. Stoner R, Chow ML, Boyle MP, Sunkin SM, Mouton PR, Roy S, Wynshaw-Boris A, Colamarino SA, Lein ES, Courchesne E. PMID: 24670167.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansCells
    22. Using photoactivatable GFP to track axonal transport kinetics. Methods Mol Biol. 2014; 1148:203-15. Ganguly A, Roy S. PMID: 24718803.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Fast vesicle transport is required for the slow axonal transport of synapsin. J Neurosci. 2013 Sep 25; 33(39):15362-75. Tang Y, Scott D, Das U, Gitler D, Ganguly A, Roy S. PMID: 24068803.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    24. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 07; 79(3):447-60. Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. PMID: 23931995.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    25. Seeing the unseen: the hidden world of slow axonal transport. Neuroscientist. 2014 Feb; 20(1):71-81. Roy S. PMID: 23912032.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    26. a-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis. J Neurosci. 2012 Jul 25; 32(30):10129-35. Scott D, Roy S. PMID: 22836248.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    27. The slow axonal transport of alpha-synuclein--mechanistic commonalities amongst diverse cytosolic cargoes. Cytoskeleton (Hoboken). 2012 Jul; 69(7):506-13. Tang Y, Das U, Scott DA, Roy S. PMID: 22344896.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    28. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid ß-protein oligomers. Traffic. 2012 May; 13(5):681-93. Tang Y, Scott DA, Das U, Edland SD, Radomski K, Koo EH, Roy S. PMID: 22309053.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    29. A simple photoactivation and image analysis module for visualizing and analyzing axonal transport with high temporal resolution. Nat Protoc. 2011 Dec 15; 7(1):62-8. Roy S, Yang G, Tang Y, Scott DA. PMID: 22179592.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    30. Mechanistic logic underlying the axonal transport of cytosolic proteins. Neuron. 2011 May 12; 70(3):441-54. Scott DA, Das U, Tang Y, Roy S. PMID: 21555071.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    31. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci. 2010 Jun 16; 30(24):8083-95. Scott DA, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. PMID: 20554859.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    32. Successful treatment of the murine model of cystinosis using bone marrow cell transplantation. Blood. 2009 Sep 17; 114(12):2542-52. Syres K, Harrison F, Tadlock M, Jester JV, Simpson J, Roy S, Salomon DR, Cherqui S. PMID: 19506297.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    33. The paradoxical cell biology of alpha-Synucle. Results Probl Cell Differ. 2009; 48:159-72. Roy S. PMID: 19582404.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    34. Cytoskeletal requirements in axonal transport of slow component-b. J Neurosci. 2008 May 14; 28(20):5248-56. Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. PMID: 18480281.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    35. Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Mol Biol Cell. 2008 Mar; 19(3):1093-103. Soper JH, Roy S, Stieber A, Lee E, Wilson RB, Trojanowski JQ, Burd CG, Lee VM. PMID: 18172022.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    36. Rapid and intermittent cotransport of slow component-b proteins. J Neurosci. 2007 Mar 21; 27(12):3131-8. Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. PMID: 17376974.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    37. Transport of neurofilaments in growing axons requires microtubules but not actin filaments. J Neurosci Res. 2005 Feb 15; 79(4):442-50. Francis F, Roy S, Brady ST, Black MM. PMID: 15635594.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
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