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Subhojit Roy

Title(s)Professor, Pathology
SchoolHealth Sciences
Phone858-246-5419
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    Enabling Nanoplatforms for Targeted in vivo Delivery of CRISPR/Cas9 Ribonucleoproteins in the Brain
    NIH/NINDS UG3NS111688Sep 30, 2018 - Jul 31, 2021
    Role: Co-Principal Investigator
    A CRISPR-Cas9 screen to identify genetic modifiers of APP/BACE-1 interactions
    NIH/NIA R21AG052404Jul 15, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Trafficking and Endosomal Sorting of APP and BACE-1
    NIH/NIA R01AG048218Sep 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Slow axonal transport of cytosolic cargoes by dynamic-recruitment - a new traffic
    NIH/NINDS R01NS075233Jan 15, 2012 - May 31, 2024
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sun J, Wang L, Bao H, Premi S, Das U, Chapman ER, Roy S. Functional cooperation of a-synuclein and VAMP2 in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2019 Jun 04; 116(23):11113-11115. PMID: 31110017.
      View in: PubMed
    2. Atias M, Tevet Y, Sun J, Stavsky A, Tal S, Kahn J, Roy S, Gitler D. Synapsins regulate a-synuclein functions. Proc Natl Acad Sci U S A. 2019 Jun 04; 116(23):11116-11118. PMID: 31110014.
      View in: PubMed
    3. Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. CRISPR/Cas9 editing of APP C-terminus attenuates ß-cleavage and promotes a-cleavage. Nat Commun. 2019 01 03; 10(1):53. PMID: 30604771.
      View in: PubMed
    4. Chakrabarty N, Dubey P, Tang Y, Ganguly A, Ladt K, Leterrier C, Jung P, Roy S. Processive flow by biased polymerization mediates the slow axonal transport of actin. J Cell Biol. 2019 Jan 07; 218(1):112-124. PMID: 30401699.
      View in: PubMed
    5. Roy S. Author Correction: Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease. Nat Neurosci. 2018 Jul; 21(7):1015. PMID: 29263407.
      View in: PubMed
    6. Sun J, Roy S. The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis. Dev Neurobiol. 2018 03; 78(3):340-347. PMID: 29106038.
      View in: PubMed
    7. Leterrier C, Dubey P, Roy S. The nano-architecture of the axonal cytoskeleton. Nat Rev Neurosci. 2017 12; 18(12):713-726. PMID: 29097785.
      View in: PubMed
    8. Roy S. Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease. Nat Neurosci. 2017 10 26; 20(11):1514-1515. PMID: 29073642.
      View in: PubMed
    9. Palmeri A, Ricciarelli R, Gulisano W, Rivera D, Rebosio C, Calcagno E, Tropea MR, Conti S, Das U, Roy S, Pronzato MA, Arancio O, Fedele E, Puzzo D. Amyloid-ß Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory. J Neurosci. 2017 07 19; 37(29):6926-6937. PMID: 28626017.
      View in: PubMed
    10. Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, Gitler D, Caillol G, Leterrier C, Yates JR, Roy S. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017 07 03; 216(7):2059-2074. PMID: 28559423.
      View in: PubMed
    11. Adamowicz DH, Roy S, Salmon DP, Galasko DR, Hansen LA, Masliah E, Gage FH. Hippocampal a-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. J Neurosci. 2017 02 15; 37(7):1675-1684. PMID: 28039370.
      View in: PubMed
    12. Roy S. Dynein's Life in the Slow Lane. Neuron. 2016 06 01; 90(5):907-9. PMID: 27253442.
      View in: PubMed
    13. Roy S. Waves, rings, and trails: The scenic landscape of axonal actin. J Cell Biol. 2016 Jan 18; 212(2):131-4. PMID: 26754647.
      View in: PubMed
    14. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan; 19(1):55-64. PMID: 26642089; PMCID: PMC4782935.
    15. Tuszynski MH, Yang JH, Barba D, U HS, Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, Nagahara AH. Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease. JAMA Neurol. 2015 Oct; 72(10):1139-47. PMID: 26302439; PMCID: PMC4944824.
    16. Ladt K, Ganguly A, Roy S. Axonal actin in action: Imaging actin dynamics in neurons. Methods Cell Biol. 2016; 131:91-106. PMID: 26794509.
      View in: PubMed
    17. Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent B, Leterrier C, Roy S. A dynamic formin-dependent deep F-actin network in axons. J Cell Biol. 2015 Aug 03; 210(3):401-17. PMID: 26216902; PMCID: PMC4523607.
    18. Wang L, Das U, Scott DA, Tang Y, McLean PJ, Roy S. a-synuclein multimers cluster synaptic vesicles and attenuate recycling. Curr Biol. 2014 Oct 06; 24(19):2319-26. PMID: 25264250.
      View in: PubMed
    19. Stoner R, Chow ML, Boyle MP, Sunkin SM, Mouton PR, Roy S, Wynshaw-Boris A, Colamarino SA, Lein ES, Courchesne E. Patches of disorganization in the neocortex of children with autism. N Engl J Med. 2014 Mar 27; 370(13):1209-1219. PMID: 24670167; PMCID: PMC4499461.
    20. Ganguly A, Roy S. Using photoactivatable GFP to track axonal transport kinetics. Methods Mol Biol. 2014; 1148:203-15. PMID: 24718803.
      View in: PubMed
    21. Tang Y, Scott D, Das U, Gitler D, Ganguly A, Roy S. Fast vesicle transport is required for the slow axonal transport of synapsin. J Neurosci. 2013 Sep 25; 33(39):15362-75. PMID: 24068803; PMCID: PMC3782618.
    22. Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 07; 79(3):447-60. PMID: 23931995.
      View in: PubMed
    23. Roy S. Seeing the unseen: the hidden world of slow axonal transport. Neuroscientist. 2014 Feb; 20(1):71-81. PMID: 23912032.
      View in: PubMed
    24. Scott D, Roy S. a-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis. J Neurosci. 2012 Jul 25; 32(30):10129-35. PMID: 22836248.
      View in: PubMed
    25. Tang Y, Das U, Scott DA, Roy S. The slow axonal transport of alpha-synuclein--mechanistic commonalities amongst diverse cytosolic cargoes. Cytoskeleton (Hoboken). 2012 Jul; 69(7):506-13. PMID: 22344896; PMCID: PMC3376189.
    26. Tang Y, Scott DA, Das U, Edland SD, Radomski K, Koo EH, Roy S. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid ß-protein oligomers. Traffic. 2012 May; 13(5):681-93. PMID: 22309053.
      View in: PubMed
    27. Roy S, Yang G, Tang Y, Scott DA. A simple photoactivation and image analysis module for visualizing and analyzing axonal transport with high temporal resolution. Nat Protoc. 2011 Dec 15; 7(1):62-8. PMID: 22179592.
      View in: PubMed
    28. Scott DA, Das U, Tang Y, Roy S. Mechanistic logic underlying the axonal transport of cytosolic proteins. Neuron. 2011 May 12; 70(3):441-54. PMID: 21555071.
      View in: PubMed
    29. Scott DA, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci. 2010 Jun 16; 30(24):8083-95. PMID: 20554859; PMCID: PMC2901533.
    30. Syres K, Harrison F, Tadlock M, Jester JV, Simpson J, Roy S, Salomon DR, Cherqui S. Successful treatment of the murine model of cystinosis using bone marrow cell transplantation. Blood. 2009 Sep 17; 114(12):2542-52. PMID: 19506297.
      View in: PubMed
    31. Roy S. The paradoxical cell biology of alpha-Synucle. Results Probl Cell Differ. 2009; 48:159-72. PMID: 19582404.
      View in: PubMed
    32. Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. Cytoskeletal requirements in axonal transport of slow component-b. J Neurosci. 2008 May 14; 28(20):5248-56. PMID: 18480281.
      View in: PubMed
    33. Soper JH, Roy S, Stieber A, Lee E, Wilson RB, Trojanowski JQ, Burd CG, Lee VM. Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Mol Biol Cell. 2008 Mar; 19(3):1093-103. PMID: 18172022.
      View in: PubMed
    34. Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. Rapid and intermittent cotransport of slow component-b proteins. J Neurosci. 2007 Mar 21; 27(12):3131-8. PMID: 17376974.
      View in: PubMed
    35. Francis F, Roy S, Brady ST, Black MM. Transport of neurofilaments in growing axons requires microtubules but not actin filaments. J Neurosci Res. 2005 Feb 15; 79(4):442-50. PMID: 15635594.
      View in: PubMed