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Miriam Scadeng

TitleAssociate Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentRadiology
Address9500 Gilman Drive #0677
La Jolla CA 92093
Phone858-822-0549
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    Collapse Biography 
    Collapse Education and Training
    University of LondonFellowshipGreat Ormond Street Hospital for Sick Children
    University of CambridgeRadiologyAddenbrooke’s Hospital
    University of CambridgeM.D.Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Quantitative MRI of Pulmonary VEGF Expression
    NIH/NCRR R21RR021919Jun 18, 2007 - May 31, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. York JM, Scadeng M, McCracken KG, Milsom WK. Respiratory mechanics and morphology of Tibetan and Andean high-altitude geese with divergent life histories. J Exp Biol. 2018 Jan 10; 221(Pt 1). PMID: 29180602.
      View in: PubMed
    2. Wright AK, Theilmann RJ, Ridgway SH, Scadeng M. Diffusion tractography reveals pervasive asymmetry of cerebral white matter tracts in the bottlenose dolphin (Tursiops truncatus). Brain Struct Funct. 2018 May; 223(4):1697-1711. PMID: 29189908.
      View in: PubMed
    3. Smith ZM, Krizay E, Sá RC, Li ET, Scadeng M, Powell FL, Dubowitz DJ. Evidence from high-altitude acclimatization for an integrated cerebrovascular and ventilatory hypercapnic response but different responses to hypoxia. J Appl Physiol (1985). 2017 12 01; 123(6):1477-1486. PMID: 28705997.
      View in: PubMed
    4. Rich B, Scadeng M, Yamaguchi M, Wagner PD, Breen EC. Skeletal myofiber vascular endothelial growth factor is required for the exercise training-induced increase in dentate gyrus neuronal precursor cells. J Physiol. 2017 Sep 01; 595(17):5931-5943. PMID: 28597506.
      View in: PubMed
    5. Tsigelny IF, Mukthavaram R, Kouznetsova VL, Chao Y, Babic I, Nurmemmedov E, Pastorino S, Jiang P, Calligaris D, Agar N, Scadeng M, Pingle SC, Wrasidlo W, Makale MT, Kesari S. Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma. Oncotarget. 2017 Apr 04; 8(14):22370-22384. PMID: 26517684.
      View in: PubMed
    6. Breen EC, Scadeng M, Lai NC, Murray F, Bigby TD. Functional magnetic resonance imaging for in vivo quantification of pulmonary hypertension in the Sugen 5416/hypoxia mouse. Exp Physiol. 2017 03 01; 102(3):347-353. PMID: 27897352.
      View in: PubMed
    7. Sumbria RK, Grigoryan MM, Vasilevko V, Krasieva TB, Scadeng M, Dvornikova AK, Paganini-Hill A, Kim R, Cribbs DH, Fisher MJ. A murine model of inflammation-induced cerebral microbleeds. J Neuroinflammation. 2016 08 30; 13(1):218. PMID: 27577728.
      View in: PubMed
    8. Eddinger KA, Rondon ES, Shubayev VI, Grafe MR, Scadeng M, Hildebrand KR, Page LM, Malkmus SA, Steinauer JJ, Yaksh TL. Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation. Anesthesiology. 2016 08; 125(2):378-94. PMID: 27272672.
      View in: PubMed
    9. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. PMID: 27281208; PMCID: PMC4998062 [Available on 12/16/16].
    10. Wright A, Scadeng M, Stec D, Dubowitz R, Ridgway S, Leger JS. Neuroanatomy of the killer whale (Orcinus orca): a magnetic resonance imaging investigation of structure with insights on function and evolution. Brain Struct Funct. 2017 01; 222(1):417-436. PMID: 27119362.
      View in: PubMed
    11. McKenna BS, Brown GG, Archibald S, Scadeng M, Bussell R, Kesby JP, Markou A, Soontornniyomkij V, Achim C, Semenova S. Microstructural changes to the brain of mice after methamphetamine exposure as identified with diffusion tensor imaging. Psychiatry Res Neuroimaging. 2016 Mar 30; 249:27-37. PMID: 27000304.
      View in: PubMed
    12. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. PMID: 26748707; PMCID: PMC4831919.
    13. Li Y, Huang Y, Wang Z, Carniato F, Xie Y, Patterson JP, Thompson MP, Andolina CM, Ditri TB, Millstone JE, Figueroa JS, Rinehart JD, Scadeng M, Botta M, Gianneschi NC. Polycatechol Nanoparticle MRI Contrast Agents. Small. 2016 Feb 03; 12(5):668-77. PMID: 26681255.
      View in: PubMed
    14. Kesby JP, Kim JJ, Scadeng M, Woods G, Kado DM, Olefsky JM, Jeste DV, Achim CL, Semenova S. Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet. PLoS One. 2015; 10(10):e0140034. PMID: 26448649; PMCID: PMC4598128.
    15. Kirscher L, Deán-Ben XL, Scadeng M, Zaremba A, Zhang Q, Kober C, Fehm TF, Razansky D, Ntziachristos V, Stritzker J, Szalay AA. Doxycycline Inducible Melanogenic Vaccinia Virus as Theranostic Anti-Cancer Agent. Theranostics. 2015; 5(10):1045-57. PMID: 26199644; PMCID: PMC4508495.
    16. Danil K, St Leger JA, Dennison S, Bernaldo de Quirós Y, Scadeng M, Nilson E, Beaulieu N. Clostridium perfringens septicemia in a long-beaked common dolphin Delphinus capensis: an etiology of gas bubble accumulation in cetaceans. Dis Aquat Organ. 2014 Oct 16; 111(3):183-90. PMID: 25320031.
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    17. Darquenne C, Borja MG, Oakes JM, Breen EC, Olfert IM, Scadeng M, Prisk GK. Increase in relative deposition of fine particles in the rat lung periphery in the absence of gravity. J Appl Physiol (1985). 2014 Oct 15; 117(8):880-6. PMID: 25170069; PMCID: PMC4199993.
    18. Oakes JM, Breen EC, Scadeng M, Tchantchou GS, Darquenne C. MRI-based measurements of aerosol deposition in the lung of healthy and elastase-treated rats. J Appl Physiol (1985). 2014 Jun 15; 116(12):1561-8. PMID: 24790020; PMCID: PMC4064380.
    19. Masuda T, Fu Y, Eguchi A, Czogalla J, Rose MA, Kuczkowski A, Gerasimova M, Feldstein AE, Scadeng M, Vallon V. Dipeptidyl peptidase IV inhibitor lowers PPAR? agonist-induced body weight gain by affecting food intake, fat mass, and beige/brown fat but not fluid retention. Am J Physiol Endocrinol Metab. 2014 Feb 15; 306(4):E388-98. PMID: 24347054; PMCID: PMC3923087.
    20. Lindsey JD, Grob SR, Scadeng M, Duong-Polk K, Weinreb RN. Ocular integrity following manganese labeling of the visual system for MRI. Magn Reson Imaging. 2013 Jul; 31(6):865-74. PMID: 23541073.
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    21. Yaksh TL, Allen JW, Veesart SL, Horais KA, Malkmus SA, Scadeng M, Steinauer JJ, Rossi SS. Role of meningeal mast cells in intrathecal morphine-evoked granuloma formation. Anesthesiology. 2013 Mar; 118(3):664-78. PMID: 23426209; PMCID: PMC3788115.
    22. Stritzker J, Kirscher L, Scadeng M, Deliolanis NC, Morscher S, Symvoulidis P, Schaefer K, Zhang Q, Buckel L, Hess M, Donat U, Bradley WG, Ntziachristos V, Szalay AA. Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3316-20. PMID: 23401518; PMCID: PMC3587225.
    23. Oakes JM, Scadeng M, Breen EC, Prisk GK, Darquenne C. Regional distribution of aerosol deposition in rat lungs using magnetic resonance imaging. Ann Biomed Eng. 2013 May; 41(5):967-78. PMID: 23354670; PMCID: PMC3625510.
    24. Hunt JS, Theilmann RJ, Smith ZM, Scadeng M, Dubowitz DJ. Cerebral diffusion and T(2): MRI predictors of acute mountain sickness during sustained high-altitude hypoxia. J Cereb Blood Flow Metab. 2013 Mar; 33(3):372-80. PMID: 23211961; PMCID: PMC3587813.
    25. Smith ZM, Krizay E, Guo J, Shin DD, Scadeng M, Dubowitz DJ. Sustained high-altitude hypoxia increases cerebral oxygen metabolism. J Appl Physiol (1985). 2013 Jan 01; 114(1):11-8. PMID: 23019310; PMCID: PMC3544513.
    26. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. PMID: 22958918; PMCID: PMC3687365.
    27. Kakinohana O, Scadeng M, Corleto JA, Sevc J, Lukacova N, Marsala M. Development of AMPA receptor and GABA B receptor-sensitive spinal hyper-reflexia after spinal air embolism in rat: a systematic neurological, electrophysiological and qualitative histopathological study. Exp Neurol. 2012 Sep; 237(1):26-35. PMID: 22721766; PMCID: PMC3430717.
    28. Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky JM. G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest. 2012 Jul; 122(7):2444-53. PMID: 22653059; PMCID: PMC3386820.
    29. Oakes JM, Scadeng M, Breen EC, Marsden AL, Darquenne C. Rat airway morphometry measured from in situ MRI-based geometric models. J Appl Physiol (1985). 2012 Jun; 112(11):1921-31. PMID: 22461437; PMCID: PMC3379152.
    30. Navarro R, Juhas S, Keshavarzi S, Juhasova J, Motlik J, Johe K, Marsala S, Scadeng M, Lazar P, Tomori Z, Schulteis G, Beattie M, Ciacci JD, Marsala M. Chronic spinal compression model in minipigs: a systematic behavioral, qualitative, and quantitative neuropathological study. J Neurotrauma. 2012 Feb 10; 29(3):499-513. PMID: 22029501; PMCID: PMC3278823.
    31. Dubowitz DJ, Scadeng M. A frameless stereotaxic MRI technique for macaque neuroscience studies. Open Neuroimag J. 2011; 5:198-205. PMID: 22253662; PMCID: PMC3257065.
    32. Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM. Adipocyte NCoR knockout decreases PPAR? phosphorylation and enhances PPAR? activity and insulin sensitivity. Cell. 2011 Nov 11; 147(4):815-26. PMID: 22078880; PMCID: PMC3783197.
    33. Hill PJ, Stritzker J, Scadeng M, Geissinger U, Haddad D, Basse-Lüsebrink TC, Gbureck U, Jakob P, Szalay AA. Magnetic resonance imaging of tumors colonized with bacterial ferritin-expressing Escherichia coli. PLoS One. 2011; 6(10):e25409. PMID: 21984917; PMCID: PMC3184983.
    34. Kinsella JM, Ananda S, Andrew JS, Grondek JF, Chien MP, Scadeng M, Gianneschi NC, Ruoslahti E, Sailor MJ. Enhanced magnetic resonance contrast of Fe3O4 nanoparticles trapped in a porous silicon nanoparticle host. Adv Mater. 2011 Sep 22; 23(36):H248-53. PMID: 21842475; PMCID: PMC3548421.
    35. Tian P, Teng IC, May LD, Kurz R, Lu K, Scadeng M, Hillman EM, De Crespigny AJ, D'Arceuil HE, Mandeville JB, Marota JJ, Rosen BR, Liu TT, Boas DA, Buxton RB, Dale AM, Devor A. Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15246-51. PMID: 20696904; PMCID: PMC2930564.
    36. Erten A, Wrasidlo W, Scadeng M, Esener S, Hoffman RM, Bouvet M, Makale M. Magnetic resonance and fluorescence imaging of doxorubicin-loaded nanoparticles using a novel in vivo model. Nanomedicine. 2010 Dec; 6(6):797-807. PMID: 20599526; PMCID: PMC2980586.
    37. Usvald D, Vodicka P, Hlucilova J, Prochazka R, Motlik J, Kuchorova K, Johe K, Marsala S, Scadeng M, Kakinohana O, Navarro R, Santa M, Hefferan MP, Yaksh TL, Marsala M. Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immunosuppressed minipigs. Cell Transplant. 2010; 19(9):1103-22. PMID: 20412634.
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    38. Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, Scadeng M, Tsien RY. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4311-6. PMID: 20160077; PMCID: PMC2840175.
    39. Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4317-22. PMID: 20160097; PMCID: PMC2840114.
    40. Michiue H, Eguchi A, Scadeng M, Dowdy SF. Induction of in vivo synthetic lethal RNAi responses to treat glioblastoma. Cancer Biol Ther. 2009 Dec; 8(23):2306-13. PMID: 19901546.
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    41. Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson RS. The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest. 2009 Nov; 119(11):3373-83. PMID: 19809162.
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    42. Marumoto T, Tashiro A, Friedmann-Morvinski D, Scadeng M, Soda Y, Gage FH, Verma IM. Development of a novel mouse glioma model using lentiviral vectors. Nat Med. 2009 Jan; 15(1):110-6. PMID: 19122659; PMCID: PMC2671237.
    43. Rossiter HB, Scadeng M, Tang K, Wagner PD, Breen EC. Doxycycline treatment prevents alveolar destruction in VEGF-deficient mouse lung. J Cell Biochem. 2008 May 15; 104(2):525-35. PMID: 18181212.
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    44. Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S. Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol. 2008 May; 172(5):1312-24. PMID: 18403587; PMCID: PMC2329840.
    45. Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky JM, Karin M. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007 Nov; 6(5):386-97. PMID: 17983584.
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    46. Wei S, Scadeng M, Yamashita DD, Pollack H, Faridi O, Tran B, Shuler C, Yen S. Manipulating the mandibular distraction site at different stages of consolidation. J Oral Maxillofac Surg. 2007 May; 65(5):840-6. PMID: 17448830.
      View in: PubMed
    47. Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky JM. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007 Apr; 13(4):455-62. PMID: 17351624.
      View in: PubMed
    48. Lindsey JD, Scadeng M, Dubowitz DJ, Crowston JG, Weinreb RN. Magnetic resonance imaging of the visual system in vivo: transsynaptic illumination of V1 and V2 visual cortex. Neuroimage. 2007 Feb 15; 34(4):1619-26. PMID: 17204432.
      View in: PubMed
    49. Scadeng M, Rossiter HB, Dubowitz DJ, Breen EC. High-resolution three-dimensional magnetic resonance imaging of mouse lung in situ. Invest Radiol. 2007 Jan; 42(1):50-7. PMID: 17213749.
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    50. Ridgway S, Houser D, Finneran J, Carder D, Keogh M, Van Bonn W, Smith C, Scadeng M, Dubowitz D, Mattrey R, Hoh C. Functional imaging of dolphin brain metabolism and blood flow. J Exp Biol. 2006 Aug; 209(Pt 15):2902-10. PMID: 16857874.
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    51. Ghugre NR, Martin M, Scadeng M, Ruffins S, Hiltner T, Pautler R, Waters C, Readhead C, Jacobs R, Wood JC. Superiority of 3D wavelet-packet denoising in MR microscopy. Magn Reson Imaging. 2003 Oct; 21(8):913-21. PMID: 14599542.
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    52. Sohara Y, Shimada H, Scadeng M, Pollack H, Yamada S, Ye W, Reynolds CP, DeClerck YA. Lytic bone lesions in human neuroblastoma xenograft involve osteoclast recruitment and are inhibited by bisphosphonate. Cancer Res. 2003 Jun 15; 63(12):3026-31. PMID: 12810621.
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