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Alysson Muotri

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentCellular and Molecular Medicine
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-534-9320
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    Collapse Overview 
    Collapse Overview
    The complexity of the human brain, with thousands of neuronal types, permits the development of sophisticated behavioral repertoires, such as language, tool use, self-awareness, symbolic thought, cultural learning and consciousness. From such dynamic complexity emerged extraordinary technological and artistic masterpieces in a relatively short cultural history. Moreover, brain complexity has a creative purpose. Understanding what produces neuronal diversification during brain development has been a longstanding challenge for neuroscientists and may bring insights into the evolution of human cognition.
    The Muotri lab explores mobile elements as generators of diversity during neuronal differentiation. These mobile elements may be part of a conserved genetic core process responsible for evoking facilitated complex non-random phenotypical variation upon which selection may act. The lab uses animal models, neural stem cells, human and other primates’ pluripotent cells and several molecular tools to investigate fundamental mechanisms of brain development, evolution and neural disorders, including Autism Spectrum Disorders.

    Research Focus Areas:

  • Developmental Biology

  • DNA Replication and Repair

  • Genetics and Genomics

  • Gene Expression and Regulation

  • Neurodevelopment and Neurodegenerative Disease

  • Stem Cell Biology



  • Collapse Research 
    Collapse Research Activities and Funding
    Novel therapy for Fragile X syndrome
    NIH/NIMH R41MH115529Sep 15, 2017 - Jul 31, 2019
    Role: Co-Principal Investigator
    Integrative functional genomic study of pathways impacted by recurrent autism CNV
    NIH/NIMH R01MH108528Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    A human neurodevelopmental model for Williams syndrome
    NIH/NIMH R56MH109587Sep 1, 2016 - Aug 31, 2017
    Role: Principal Investigator
    Evaluating the effect of splicing mutations on isoform networks in autism
    NIH/NIMH R01MH109885May 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    A chimeric brain model to study human neurological diseases
    NIH/NIMH R21MH107771Sep 25, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
    NIH/NIMH U19MH107367Sep 21, 2015 - Jun 30, 2020
    Role: Co-Investigator
    Exosome-mediated cell-cell signaling in Rett Syndrome
    NIH/NIMH R01MH103134Sep 26, 2013 - Jul 31, 2017
    Role: Principal Investigator
    Proteogenetics of Autism Spectrum Disorders
    NIH/NIMH R01MH100175Aug 1, 2013 - Mar 31, 2021
    Role: Principal Investigator
    Modeling anorexia nervosa with human pluripotent stem cells
    NIH/NIMH R21MH093954Jan 15, 2012 - Nov 30, 2013
    Role: Principal Investigator
    The Impact of L1retrotransposition in the nervous system
    NIH/NIMH R01MH094753Aug 16, 2011 - May 31, 2016
    Role: Principal Investigator
    Modeling autism with human pluripotent cells
    NIH DP2OD006495Sep 30, 2009 - Jun 30, 2014
    Role: Principal Investigator
    Administrative Core
    NIH/NIMH U19MH-01
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Schukking M, Miranda HC, Trujillo CA, Negraes PD, Muotri AR. Direct generation of human cortical organoids from primary cells. Stem Cells Dev. 2018 Aug 24. PMID: 30142987.
      View in: PubMed
    2. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. Author Correction: Blocking Zika virus vertical transmission. Sci Rep. 2018 Jun 05; 8(1):8794. PMID: 29867187.
      View in: PubMed
    3. Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M. Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. Sci Transl Med. 2018 May 09; 10(440). PMID: 29743351.
      View in: PubMed
    4. Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH. Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2018 Apr 27. PMID: 29703932.
      View in: PubMed
    5. Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J. Paternally inherited cis-regulatory structural variants are associated with autism. Science. 2018 04 20; 360(6386):327-331. PMID: 29674594.
      View in: PubMed
    6. Muotri AR. Autism spectrum disorders: Challenges and perspectives. Dev Neurobiol. 2018 May; 78(5):431-433. PMID: 29516662.
      View in: PubMed
    7. Fernandes IR, Cruz ACP, Ferrasa A, Phan D, Herai RH, Muotri AR. Genetic variations on SETD5 underlying autistic conditions. Dev Neurobiol. 2018 May; 78(5):500-518. PMID: 29484850.
      View in: PubMed
    8. Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. Blocking Zika virus vertical transmission. Sci Rep. 2018 Jan 19; 8(1):1218. PMID: 29352135.
      View in: PubMed
    9. Chailangkarn T, Noree C, Muotri AR. The contribution of GTF2I haploinsufficiency to Williams syndrome. Mol Cell Probes. 2018 Jan 03. PMID: 29305905.
      View in: PubMed
    10. Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, de A Zanotto PM, Beltrão-Braga PCB, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Hum Mol Genet. 2018 Jan 01; 27(1):41-52. PMID: 29048558.
      View in: PubMed
    11. Suarez NA, Macia A, Muotri AR. LINE-1 retrotransposons in healthy and diseased human brain. Dev Neurobiol. 2018 May; 78(5):434-455. PMID: 29239145.
      View in: PubMed
    12. Shiryaev SA, Mesci P, Pinto A, Fernandes I, Sheets N, Shresta S, Farhy C, Huang CT, Strongin AY, Muotri AR, Terskikh AV. Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis. Sci Rep. 2017 Nov 17; 7(1):15771. PMID: 29150641.
      View in: PubMed
    13. Yoo M, Carromeu C, Kwon O, Muotri A, Schachner M. The L1 adhesion molecule normalizes neuritogenesis in Rett syndrome-derived neural precursor cells. Biochem Biophys Res Commun. 2017 12 16; 494(3-4):504-510. PMID: 29050935.
      View in: PubMed
    14. Russo FB, Freitas BC, Pignatari GC, Fernandes IR, Sebat J, Muotri AR, Beltrão-Braga PCB. Modeling the Interplay Between Neurons and Astrocytes in Autism Using Human Induced Pluripotent Stem Cells. Biol Psychiatry. 2018 Apr 01; 83(7):569-578. PMID: 29129319.
      View in: PubMed
    15. Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH. Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2017 09 28; 20(10):1427. PMID: 28949329.
      View in: PubMed
    16. Brito A, Russo FB, Muotri AR, Beltrão-Braga PCB. Autism spectrum disorders and disease modeling using stem cells. Cell Tissue Res. 2018 01; 371(1):153-160. PMID: 28918504.
      View in: PubMed
    17. Thomas CA, Tejwani L, Trujillo CA, Negraes PD, Herai RH, Mesci P, Macia A, Crow YJ, Muotri AR. Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation. Cell Stem Cell. 2017 Sep 07; 21(3):319-331.e8. PMID: 28803918.
      View in: PubMed
    18. Herai RH, Negraes PD, Muotri AR. Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA. Hum Mol Genet. 2017 07 01; 26(13):2472-2479. PMID: 28430982.
      View in: PubMed
    19. Herai RH, Negraes PD, Muotri AR. Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA. Hum Mol Genet. 2017 07 01; 26(13):2590. PMID: 28637317.
      View in: PubMed
    20. Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage FH, Boeke JD, An W. Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A. 2017 Jul 11; 114(28):E5635-E5644. PMID: 28630288.
      View in: PubMed
    21. Liang N, Trujillo CA, Negraes PD, Muotri AR, Lameu C, Ulrich H. Stem cell contributions to neurological disease modeling and personalized medicine. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 03; 80(Pt A):54-62. PMID: 28576415.
      View in: PubMed
    22. Chailangkarn T, Muotri AR. Modeling Williams syndrome with induced pluripotent stem cells. Neurogenesis (Austin). 2017; 4(1):e1283187. PMID: 28229087.
      View in: PubMed
    23. de Souza JS, Carromeu C, Torres LB, Araujo BH, Cugola FR, Maciel RM, Muotri AR, Giannocco G. IGF1 neuronal response in the absence of MECP2 is dependent on TRalpha 3. Hum Mol Genet. 2017 01 15; 26(2):270-281. PMID: 28007906.
      View in: PubMed
    24. Griesi-Oliveira K, Suzuki AM, Muotri AR. TRPC Channels and Mental Disorders. Adv Exp Med Biol. 2017; 976:137-148. PMID: 28508319.
      View in: PubMed
    25. Macia A, Widmann TJ, Heras SR, Ayllon V, Sanchez L, Benkaddour-Boumzaouad M, Muñoz-Lopez M, Rubio A, Amador-Cubero S, Blanco-Jimenez E, Garcia-Castro J, Menendez P, Ng P, Muotri AR, Goodier JL, Garcia-Perez JL. Engineered LINE-1 retrotransposition in nondividing human neurons. Genome Res. 2017 03; 27(3):335-348. PMID: 27965292.
      View in: PubMed
    26. Langley GR, Adcock IM, Busquet F, Crofton KM, Csernok E, Giese C, Heinonen T, Herrmann K, Hofmann-Apitius M, Landesmann B, Marshall LJ, McIvor E, Muotri AR, Noor F, Schutte K, Seidle T, van de Stolpe A, Van Esch H, Willett C, Woszczek G. Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations. Drug Discov Today. 2017 02; 22(2):327-339. PMID: 27989722.
      View in: PubMed
    27. Yao H, Azad P, Zhao HW, Wang J, Poulsen O, Freitas BC, Muotri AR, Haddad GG. The Na+/HCO3- co-transporter is protective during ischemia in astrocytes. Neuroscience. 2016 Dec 17; 339:329-337. PMID: 27717805.
      View in: PubMed
    28. Erwin JA, Paquola AC, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FI, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH. L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2016 12; 19(12):1583-1591. PMID: 27618310.
      View in: PubMed
    29. Pillat MM, Lameu C, Trujillo CA, Glaser T, Cappellari AR, Negraes PD, Battastini AM, Schwindt TT, Muotri AR, Ulrich H. Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation. J Cell Sci. 2016 09 15; 129(18):3437-48. PMID: 27528403.
      View in: PubMed
    30. Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MC, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard MC, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage FH, Bellugi U, Halgren E, Semendeferi K, Muotri AR. A human neurodevelopmental model for Williams syndrome. Nature. 2016 08 18; 536(7616):338-43. PMID: 27509850.
      View in: PubMed
    31. Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Mol Psychiatry. 2017 Jun; 22(6):820-835. PMID: 27378147.
      View in: PubMed
    32. Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S, Polonio CM, Cunha I, Freitas CL, Brandão WN, Rossato C, Andrade DG, Faria Dde P, Garcez AT, Buchpigel CA, Braconi CT, Mendes E, Sall AA, Zanotto PM, Peron JP, Muotri AR, Beltrão-Braga PC. The Brazilian Zika virus strain causes birth defects in experimental models. Nature. 2016 06 09; 534(7606):267-71. PMID: 27279226.
      View in: PubMed
    33. Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J. Frequency and Complexity of De Novo Structural Mutation in Autism. Am J Hum Genet. 2016 Apr 07; 98(4):667-79. PMID: 27018473.
      View in: PubMed
    34. Wang Y, Jones-Tabah J, Chakravarty P, Stewart A, Muotri A, Laposa RR, Svejstrup JQ. Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation. Cell Rep. 2016 Mar 22; 14(11):2554-61. PMID: 26972010; PMCID: PMC4806223.
    35. Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A. Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3185-90. PMID: 26944080; PMCID: PMC4812712.
    36. Beltrão-Braga PC, Muotri AR. Modeling autism spectrum disorders with human neurons. Brain Res. 2017 02 01; 1656:49-54. PMID: 26854137.
      View in: PubMed
    37. de Melo JT, de Souza Timoteo AR, Lajus TB, Brandão JA, de Souza-Pinto NC, Menck CF, Campalans A, Radicella JP, Vessoni AT, Muotri AR, Agnez-Lima LF. XPC deficiency is related to APE1 and OGG1 expression and function. Mutat Res. 2016 Feb-Mar; 784-785:25-33. PMID: 26811994.
      View in: PubMed
    38. Vessoni AT, Herai RH, Karpiak JV, Leal AM, Trujillo CA, Quinet A, Agnez Lima LF, Menck CF, Muotri AR. Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony. Hum Mol Genet. 2016 Apr 01; 25(7):1271-80. PMID: 26755826.
      View in: PubMed
    39. Tang X, Kim J, Zhou L, Wengert E, Zhang L, Wu Z, Carromeu C, Muotri AR, Marchetto MC, Gage FH, Chen G. KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):751-6. PMID: 26733678; PMCID: PMC4725523.
    40. Muotri AR. L1 Retrotransposition in Neural Progenitor Cells. Methods Mol Biol. 2016; 1400:157-63. PMID: 26895053.
      View in: PubMed
    41. Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 08; 5(6):933-945. PMID: 26610635.
      View in: PubMed
    42. Langley G, Austin CP, Balapure AK, Birnbaum LS, Bucher JR, Fentem J, Fitzpatrick SC, Fowle JR, Kavlock RJ, Kitano H, Lidbury BA, Muotri AR, Peng SQ, Sakharov D, Seidle T, Trez T, Tonevitsky A, van de Stolpe A, Whelan M, Willett C. Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research. Environ Health Perspect. 2015 Nov; 123(11):A268-72. PMID: 26523530; PMCID: PMC4629751.
    43. Moszczynska A, Flack A, Qiu P, Muotri AR, Killinger BA. Neurotoxic Methamphetamine Doses Increase LINE-1 Expression in the Neurogenic Zones of the Adult Rat Brain. Sci Rep. 2015 Oct 14; 5:14356. PMID: 26463126; PMCID: PMC4604469.
    44. Melo US, Macedo-Souza LI, Figueiredo T, Muotri AR, Gleeson JG, Coux G, Armas P, Calcaterra NB, Kitajima JP, Amorim S, Olávio TR, Griesi-Oliveira K, Coatti GC, Rocha CR, Martins-Pinheiro M, Menck CF, Zaki MS, Kok F, Zatz M, Santos S. Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome. Hum Mol Genet. 2015 Dec 15; 24(24):6877-85. PMID: 26385635.
      View in: PubMed
    45. Acab A, Muotri AR. The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment. Neurotherapeutics. 2015 Jul; 12(3):534-45. PMID: 25851569; PMCID: PMC4489954.
    46. Marinho PA, Chailangkarn T, Muotri AR. Systematic optimization of human pluripotent stem cells media using Design of Experiments. Sci Rep. 2015 May 05; 5:9834. PMID: 25940691; PMCID: PMC4419516.
    47. Muotri AR. The Human Model: Changing Focus on Autism Research. Biol Psychiatry. 2016 Apr 15; 79(8):642-9. PMID: 25861701; PMCID: PMC4573784 [Available on 04/15/17].
    48. Cortes CJ, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri AR, Garden GA, La Spada AR. Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nat Neurosci. 2014 Sep; 17(9):1180-9. PMID: 25108912; PMCID: PMC4180729.
    49. Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage FH, Kosik KS, Geschwind DH. A quantitative framework to evaluate modeling of cortical development by neural stem cells. Neuron. 2014 Jul 02; 83(1):69-86. PMID: 24991955; PMCID: PMC4277209.
    50. Herai RR, Stefanacci L, Hrvoj-Mihic B, Chailangkarn T, Hanson K, Semendeferi K, Muotri AR. Micro RNA detection in long-term fixed tissue of cortical glutamatergic pyramidal neurons after targeted laser-capture neuroanatomical microdissection. J Neurosci Methods. 2014 Sep 30; 235:76-82. PMID: 24992573.
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    51. Dolezalova D, Hruska-Plochan M, Bjarkam CR, Sørensen JC, Cunningham M, Weingarten D, Ciacci JD, Juhas S, Juhasova J, Motlik J, Hefferan MP, Hazel T, Johe K, Carromeu C, Muotri A, Bui J, Strnadel J, Marsala M. Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies. J Comp Neurol. 2014 Aug 15; 522(12):2784-801. PMID: 24610493.
      View in: PubMed
    52. Hrvoj-Mihic B, Bienvenu T, Stefanacci L, Muotri AR, Semendeferi K. Evolution, development, and plasticity of the human brain: from molecules to bones. Front Hum Neurosci. 2013 Oct 30; 7:707. PMID: 24194709; PMCID: PMC3812990.
    53. Marchetto MCN, Narvaiza I, Denli AM, Benner C, Lazzarini TA, Nathanson JL, Paquola ACM, Desai KN, Herai RH, Weitzman MD, Yeo GW, Muotri AR, Gage FH. Differential L1 regulation in pluripotent stem cells of humans and apes. Nature. 2013 Nov 28; 503(7477):525-529. PMID: 24153179; PMCID: PMC4064720.
    54. Hrvoj-Mihic B, Marchetto MC, Gage FH, Semendeferi K, Muotri AR. Novel tools, classic techniques: evolutionary studies using primate pluripotent stem cells. Biol Psychiatry. 2014 Jun 15; 75(12):929-35. PMID: 24041506.
      View in: PubMed
    55. Yoshioka N, Gros E, Li HR, Kumar S, Deacon DC, Maron C, Muotri AR, Chi NC, Fu XD, Yu BD, Dowdy SF. Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013 Aug 01; 13(2):246-54. PMID: 23910086; PMCID: PMC3845961.
    56. Tang X, Zhou L, Wagner AM, Marchetto MC, Muotri AR, Gage FH, Chen G. Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. Stem Cell Res. 2013 Sep; 11(2):743-57. PMID: 23759711; PMCID: PMC3979966.
    57. Lovatel GA, Elsner VR, Bertoldi K, Vanzella C, Moysés Fdos S, Vizuete A, Spindler C, Cechinel LR, Netto CA, Muotri AR, Siqueira IR. Treadmill exercise induces age-related changes in aversive memory, neuroinflammatory and epigenetic processes in the rat hippocampus. Neurobiol Learn Mem. 2013 Mar; 101:94-102. PMID: 23357282.
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    58. Elsner VR, Lovatel GA, Moysés F, Bertoldi K, Spindler C, Cechinel LR, Muotri AR, Siqueira IR. Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary study. Exp Gerontol. 2013 Feb; 48(2):136-9. PMID: 23201423; PMCID: PMC4405233.
    59. Trujillo CA, Negraes PD, Schwindt TT, Lameu C, Carromeu C, Muotri AR, Pesquero JB, Cerqueira DM, Pillat MM, de Souza HD, Turaça LT, Abreu JG, Ulrich H. Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. J Biol Chem. 2012 Dec 28; 287(53):44046-61. PMID: 23132855; PMCID: PMC3531721.
    60. Freitas BC, Trujillo CA, Carromeu C, Yusupova M, Herai RH, Muotri AR. Stem cells and modeling of autism spectrum disorders. Exp Neurol. 2014 Oct; 260:33-43. PMID: 23036599; PMCID: PMC3568448.
    61. Miranda HC, Herai RH, Thomé CH, Gomes GG, Panepucci RA, Orellana MD, Covas DT, Muotri AR, Greene LJ, Faça VM. A quantitative proteomic and transcriptomic comparison of human mesenchymal stem cells from bone marrow and umbilical cord vein. Proteomics. 2012 Aug; 12(17):2607-17. PMID: 22778083.
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    62. Chailangkarn T, Acab A, Muotri AR. Modeling neurodevelopmental disorders using human neurons. Curr Opin Neurobiol. 2012 Oct; 22(5):785-90. PMID: 22717528; PMCID: PMC3587787.
    63. Andrade LN, Nathanson JL, Yeo GW, Menck CF, Muotri AR. Evidence for premature aging due to oxidative stress in iPSCs from Cockayne syndrome. Hum Mol Genet. 2012 Sep 01; 21(17):3825-34. PMID: 22661500; PMCID: PMC3412382.
    64. Gage FH, Muotri AR. What makes each brain unique. Sci Am. 2012 Mar; 306(3):26-31. PMID: 22375319.
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    65. Vessoni AT, Muotri AR, Okamoto OK. Autophagy in stem cell maintenance and differentiation. Stem Cells Dev. 2012 Mar 01; 21(4):513-20. PMID: 22066548.
      View in: PubMed
    66. Thomas CA, Muotri AR. LINE-1: creators of neuronal diversity. Front Biosci (Elite Ed). 2012 Jan 01; 4:1663-8. PMID: 22201983.
      View in: PubMed
    67. Thomas CA, Paquola AC, Muotri AR. LINE-1 retrotransposition in the nervous system. Annu Rev Cell Dev Biol. 2012; 28:555-73. PMID: 23057747.
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    68. Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Macia A, Moran JV, Gage FH. Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20382-7. PMID: 22159035; PMCID: PMC3251057.
    69. Ming GL, Brüstle O, Muotri A, Studer L, Wernig M, Christian KM. Cellular reprogramming: recent advances in modeling neurological diseases. J Neurosci. 2011 Nov 09; 31(45):16070-5. PMID: 22072658; PMCID: PMC3236609.
    70. Mitne-Neto M, Machado-Costa M, Marchetto MC, Bengtson MH, Joazeiro CA, Tsuda H, Bellen HJ, Silva HC, Oliveira AS, Lazar M, Muotri AR, Zatz M. Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. Hum Mol Genet. 2011 Sep 15; 20(18):3642-52. PMID: 21685205; PMCID: PMC3159551.
    71. Felfly H, Xue J, Zambon AC, Muotri A, Zhou D, Haddad GG. Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R727-45. PMID: 21677276; PMCID: PMC3174756.
    72. Beltrão-Braga PC, Pignatari GC, Maiorka PC, Oliveira NA, Lizier NF, Wenceslau CV, Miglino MA, Muotri AR, Kerkis I. Feeder-free derivation of induced pluripotent stem cells from human immature dental pulp stem cells. Cell Transplant. 2011; 20(11-12):1707-19. PMID: 21457612.
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    73. Massirer KB, Carromeu C, Griesi-Oliveira K, Muotri AR. Maintenance and differentiation of neural stem cells. Wiley Interdiscip Rev Syst Biol Med. 2011 Jan-Feb; 3(1):107-14. PMID: 21061307.
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    74. Felfly H, Zambon AC, Xue J, Muotri A, Zhou D, Snyder EY, Haddad GG. Severe Hypoxia: Consequences to Neural Stem Cells and Neurons. J Neurol Res. 2011; 1(5). PMID: 24348887.
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    75. Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, Gage FH. L1 retrotransposition in neurons is modulated by MeCP2. Nature. 2010 Nov 18; 468(7322):443-6. PMID: 21085180; PMCID: PMC3059197.
    76. Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell. 2010 Nov 12; 143(4):527-39. PMID: 21074045; PMCID: PMC3003590.
    77. Felfly H, Muotri A, Yao H, Haddad GG. Hematopoietic stem cell transplantation protects mice from lethal stroke. Exp Neurol. 2010 Oct; 225(2):284-93. PMID: 20547154; PMCID: PMC2963425.
    78. Acu ID, Liu T, Suino-Powell K, Mooney SM, D'Assoro AB, Rowland N, Muotri AR, Correa RG, Niu Y, Kumar R, Salisbury JL. Coordination of centrosome homeostasis and DNA repair is intact in MCF-7 and disrupted in MDA-MB 231 breast cancer cells. Cancer Res. 2010 Apr 15; 70(8):3320-8. PMID: 20388771; PMCID: PMC3851324.
    79. Secco M, Moreira YB, Zucconi E, Vieira NM, Jazedje T, Muotri AR, Okamoto OK, Verjovski-Almeida S, Zatz M. Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood. Stem Cell Rev. 2009 Dec; 5(4):387-401. PMID: 20058202; PMCID: PMC2803263.
    80. Muotri AR, Zhao C, Marchetto MC, Gage FH. Environmental influence on L1 retrotransposons in the adult hippocampus. Hippocampus. 2009 Oct; 19(10):1002-7. PMID: 19771587; PMCID: PMC2758700.
    81. Marchetto MC, Yeo GW, Kainohana O, Marsala M, Gage FH, Muotri AR. Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One. 2009 Sep 18; 4(9):e7076. PMID: 19763270; PMCID: PMC2741600.
    82. Kuwabara T, Hsieh J, Muotri A, Yeo G, Warashina M, Lie DC, Moore L, Nakashima K, Asashima M, Gage FH. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci. 2009 Sep; 12(9):1097-105. PMID: 19701198; PMCID: PMC2764260.
    83. Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell. 2008 Dec 04; 3(6):649-57. PMID: 19041781.
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    84. Muotri AR. Modeling epilepsy with pluripotent human cells. Epilepsy Behav. 2009 Jan; 14 Suppl 1:81-5. PMID: 18845273.
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    85. Leite RA, Marchetto MC, Muotri AR, Vasconcelos Dde M, de Oliveira ZN, Machado MC, Menck CF. Identification of XP complementation groups by recombinant adenovirus carrying DNA repair genes. J Invest Dermatol. 2009 Feb; 129(2):502-6. PMID: 18685619.
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    86. Yeo GW, Coufal N, Aigner S, Winner B, Scolnick JA, Marchetto MC, Muotri AR, Carson C, Gage FH. Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. Hum Mol Genet. 2008 Apr 15; 17(R1):R67-75. PMID: 18632700.
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    87. Secco M, Zucconi E, Vieira NM, Fogaça LL, Cerqueira A, Carvalho MD, Jazedje T, Okamoto OK, Muotri AR, Zatz M. Mesenchymal stem cells from umbilical cord: do not discard the cord! Neuromuscul Disord. 2008 Jan; 18(1):17-8. PMID: 18155523.
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    88. Cezar GG, Quam JA, Smith AM, Rosa GJ, Piekarczyk MS, Brown JF, Gage FH, Muotri AR. Identification of small molecules from human embryonic stem cells using metabolomics. Stem Cells Dev. 2007 Dec; 16(6):869-82. PMID: 18042039.
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    89. Armelini MG, Lima-Bessa KM, Marchetto MC, Muotri AR, Chiganças V, Leite RA, Carvalho H, Menck CF. Exploring DNA damage responses in human cells with recombinant adenoviral vectors. Hum Exp Toxicol. 2007 Nov; 26(11):899-906. PMID: 18042584.
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    90. Muotri AR, Marchetto MC, Coufal NG, Gage FH. The necessary junk: new functions for transposable elements. Hum Mol Genet. 2007 Oct 15; 16 Spec No. 2:R159-67. PMID: 17911158.
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    91. Secco M, Zucconi E, Vieira NM, Fogaça LL, Cerqueira A, Carvalho MD, Jazedje T, Okamoto OK, Muotri AR, Zatz M. Multipotent stem cells from umbilical cord: cord is richer than blood! Stem Cells. 2008 Jan; 26(1):146-50. PMID: 17932423.
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    92. Yeo GW, Xu X, Liang TY, Muotri AR, Carson CT, Coufal NG, Gage FH. Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol. 2007 Oct; 3(10):1951-67. PMID: 17967047; PMCID: PMC2041973.
    93. Garcia-Perez JL, Marchetto MC, Muotri AR, Coufal NG, Gage FH, O'Shea KS, Moran JV. LINE-1 retrotransposition in human embryonic stem cells. Hum Mol Genet. 2007 Jul 01; 16(13):1569-77. PMID: 17468180.
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    94. Muotri AR, Gage FH. Generation of neuronal variability and complexity. Nature. 2006 Jun 29; 441(7097):1087-93. PMID: 16810244.
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    95. Marchetto MC, Correa RG, Menck CF, Muotri AR. Functional lentiviral vectors for xeroderma pigmentosum gene therapy. J Biotechnol. 2006 Dec 01; 126(4):424-30. PMID: 16857285.
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    96. Muotri AR, Bottero V, Tergaonkar V, Correa RG. UV-mediated NF-kappaB activation is abolished in deficient XPC/D primary fibroblasts. Cell Cycle. 2006 May; 5(10):1085-9. PMID: 16721051.
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    97. Becker C, Lacchini S, Muotri AR, da Silva GJ, Castelli JB, Vassallo PF, Menck CF, Krieger JE. Skeletal muscle cells expressing VEGF induce capillary formation and reduce cardiac injury in rats. Int J Cardiol. 2006 Nov 18; 113(3):348-54. PMID: 16675047.
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    98. Alisch RS, Garcia-Perez JL, Muotri AR, Gage FH, Moran JV. Unconventional translation of mammalian LINE-1 retrotransposons. Genes Dev. 2006 Jan 15; 20(2):210-24. PMID: 16418485; PMCID: PMC1356112.
    99. Cao X, Yeo G, Muotri AR, Kuwabara T, Gage FH. Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci. 2006; 29:77-103. PMID: 16776580.
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    100. Muotri AR, Nakashima K, Toni N, Sandler VM, Gage FH. Development of functional human embryonic stem cell-derived neurons in mouse brain. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18644-8. PMID: 16352714; PMCID: PMC1317971.
    101. Muotri AR, Chu VT, Marchetto MC, Deng W, Moran JV, Gage FH. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature. 2005 Jun 16; 435(7044):903-10. PMID: 15959507.
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    102. Lilley CE, Carson CT, Muotri AR, Gage FH, Weitzman MD. DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A. 2005 Apr 19; 102(16):5844-9. PMID: 15824307; PMCID: PMC556126.
    103. Armelini MG, Muotri AR, Marchetto MC, de Lima-Bessa KM, Sarasin A, Menck CF. Restoring DNA repair capacity of cells from three distinct diseases by XPD gene-recombinant adenovirus. Cancer Gene Ther. 2005 Apr; 12(4):389-96. PMID: 15650764.
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    104. Martin MJ, Muotri A, Gage F, Varki A. Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat Med. 2005 Feb; 11(2):228-32. PMID: 15685172.
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    105. Marchetto MC, Muotri AR, Burns DK, Friedberg EC, Menck CF. Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17759-64. PMID: 15598745; PMCID: PMC539722.
    106. Muotri AR, Gage FH. Vibrating in the background. Nat Genet. 2003 Nov; 35(3):205-7. PMID: 14593403.
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    107. Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR, Summers RG, Chun J, Lee KF, Gage FH. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6777-82. PMID: 12748381; PMCID: PMC164523.
    108. Muotri AR, Marchetto MC, Zerbini LF, Libermann TA, Ventura AM, Sarasin A, Menck CF. Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer. Hum Gene Ther. 2002 Oct 10; 13(15):1833-44. PMID: 12396616.
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    109. Muotri AR, Marchetto MC, Suzuki MF, Okazaki K, Lotfi CF, Brumatti G, Amarante-Mendes GP, Menck CF. Low amounts of the DNA repair XPA protein are sufficient to recover UV-resistance. Carcinogenesis. 2002 Jun; 23(6):1039-46. PMID: 12082027.
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