Joseph Ciacci

Title(s)Professor Of Clinical, Neurological Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Dr. Ciacci is the Principal Investigator on several Clinical Trials for Spinal Cord Injury, and Dr. Ciacci is a Clinical Trial Expert in the Sanford Stem Cell Clinical Center Alpha Clinic.

    Dr. Ciacci's primary clinical interests are spinal cord injury, tumors of the spine and brain, and complex spinal reconstruction.

    Dr. Ciacci has extensive experience with neuro-oncology of the spine and brain. He has completed neuro-oncology fellowships at UCLA and the National Institutes of Health.

    Dr. Ciacci was on the faculty at the Johns Hopkins School of Medicine for 9 years prior to joining the faculty at UC San Diego. Dr. Ciacci has been Visiting Professor and has given lectures throughout the United States and Internationally.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Characterizing the frequency, morbidity, and types of traumatic brain injuries after the Mexico-San Diego border wall extension: a retrospective cohort review. J Neurosurg. 2023 Feb 17; 1-6. Tenorio A, Brandel MG, Produturi GR, McCann CP, Wali AR, Bravo J, Godat LN, Doucet JJ, Costantini TW, Santiago-Dieppa DR, Ciacci JD. PMID: 36806495.
      View in: PubMed   Mentions:    Fields:    
    2. Derivation of Sendai-Virus-Reprogrammed Human iPSCs-Neuronal Precursors: In Vitro and In Vivo Post-grafting Safety Characterization. Cell Transplant. 2023 Jan-Dec; 32:9636897231163232. Shigyo M, Kobayashi Y, Platoshyn O, Marsala S, Kato T, Takamura N, Yoshida K, Kishino A, Bravo-Hernandez M, Juhas S, Juhasova J, Studenovska H, Proks V, Ciacci JD, Marsala M. PMID: 36959733; PMCID: PMC10041596.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Expandable Sendai-Virus-Reprogrammed Human iPSC-Neuronal Precursors: In Vivo Post-Grafting Safety Characterization in Rats and Adult Pig. Cell Transplant. 2023 Jan-Dec; 32:9636897221107009. Kobayashi Y, Shigyo M, Platoshyn O, Marsala S, Kato T, Takamura N, Yoshida K, Kishino A, Bravo-Hernandez M, Juhas S, Juhasova J, Studenovska H, Proks V, Driscoll SP, Glenn TD, Pfaff SL, Ciacci JD, Marsala M. PMID: 37088987; PMCID: PMC10134149.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Intradermal and Intramuscular Bupivacaine Reduces Opioid Use Following Noninstrumented Spine Surgery. World Neurosurg. 2023 Feb; 170:e716-e723. Cleary DR, Tan H, Ciacci J. PMID: 36442775.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. The impact of the Mexico-San Diego border wall extension on spine injuries: a retrospective cohort review. J Travel Med. 2022 11 04; 29(7). Tenorio A, Brandel MG, Produturi GR, McCann CP, Doucet JJ, Costantini TW, Ciacci JD. PMID: 36165623.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Constructing 2D maps of human spinal cord activity and isolating the functional midline with high-density microelectrode arrays. Sci Transl Med. 2022 09 28; 14(664):eabq4744. Russman SM, Cleary DR, Tchoe Y, Bourhis AM, Stedelin B, Martin J, Brown EC, Zhang X, Kawamoto A, Ryu WHA, Raslan AM, Ciacci JD, Dayeh SA. PMID: 36170445; PMCID: PMC9650777.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Precision spinal gene delivery-induced functional switch in nociceptive neurons reverses neuropathic pain. Mol Ther. 2022 08 03; 30(8):2722-2745. Tadokoro T, Bravo-Hernandez M, Agashkov K, Kobayashi Y, Platoshyn O, Navarro M, Marsala S, Miyanohara A, Yoshizumi T, Shigyo M, Krotov V, Juhas S, Juhasova J, Nguyen D, Kupcova Skalnikova H, Motlik J, Studenovska H, Proks V, Reddy R, Driscoll SP, Glenn TD, Kemthong T, Malaivijitnond S, Tomori Z, Vanicky I, Kakinohana M, Pfaff SL, Ciacci J, Belan P, Marsala M. PMID: 35524407; PMCID: PMC9372322.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Traumatic rupture of thoracic epidural capillary hemangioma resulting in acute neurologic deficit: illustrative case. J Neurosurg Case Lessons. 2021 Nov 22; 2(21):CASE21309. Kidwell RL, Stone LE, Goodwill V, Ciacci JD. PMID: 36060424; PMCID: PMC9435546.
      View in: PubMed   Mentions:
    9. Review of operative considerations in spinal cord stem cell therapy. World J Stem Cells. 2021 Feb 26; 13(2):168-176. Upadhyayula PS, Martin JR, Rennert RC, Ciacci JD. PMID: 33708345; PMCID: PMC7933987.
      View in: PubMed   Mentions: 3  
    10. Basal impulses: findings from the last twenty years on impulsivity and reward pathways using deep brain stimulation. J Neurosurg Sci. 2020 Dec; 64(6):544-551. Upadhyayula PS, Rennert RC, Martin JR, Yue JK, Yang J, Gillis-Buck EM, Sidhu N, Cheung CK, Lee AT, Hoshide RR, Ciacci JD. PMID: 32972108.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    11. Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS. Nat Med. 2020 01; 26(1):118-130. Bravo-Hernandez M, Tadokoro T, Navarro MR, Platoshyn O, Kobayashi Y, Marsala S, Miyanohara A, Juhas S, Juhasova J, Skalnikova H, Tomori Z, Vanicky I, Studenovska H, Proks V, Chen P, Govea-Perez N, Ditsworth D, Ciacci JD, Gao S, Zhu W, Ahrens ET, Driscoll SP, Glenn TD, McAlonis-Downes M, Da Cruz S, Pfaff SL, Kaspar BK, Cleveland DW, Marsala M. PMID: 31873312; PMCID: PMC8171115.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    12. Spinal parenchymal occupation by neural stem cells after subpial delivery in adult immunodeficient rats. Stem Cells Transl Med. 2020 02; 9(2):177-188. Marsala M, Kamizato K, Tadokoro T, Navarro M, Juhas S, Juhasova J, Marsala S, Studenovska H, Proks V, Hazel T, Johe K, Kakinohana M, Driscoll S, Glenn T, Pfaff S, Ciacci J. PMID: 31800978; PMCID: PMC6988771.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. Neurosurgical Management of a Thoracic Dorsal Arachnoid Web: Case Illustration. Cureus. 2019 Jun 19; 11(6):e4945. Wali AR, Birk HS, Martin J, Santiago-Dieppa DR, Ciacci J. PMID: 31453019; PMCID: PMC6701917.
      View in: PubMed   Mentions: 3  
    14. Immunosuppressive mechanisms for stem cell transplant survival in spinal cord injury. Neurosurg Focus. 2019 03 01; 46(3):E9. Antonios JP, Farah GJ, Cleary DR, Martin JR, Ciacci JD, Pham MH. PMID: 30835678.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. Anterior Versus Transforaminal Lumbar Interbody Fusion: Perioperative Risk Factors and 30-Day Outcomes. Int J Spine Surg. 2018 Oct; 12(5):533-542. Upadhyayula PS, Curtis EI, Yue JK, Sidhu N, Ciacci JD. PMID: 30364718; PMCID: PMC6198636.
      View in: PubMed   Mentions: 6  
    16. A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury. Cell Stem Cell. 2018 Jun 01; 22(6):941-950.e6. Curtis E, Martin JR, Gabel B, Sidhu N, Rzesiewicz TK, Mandeville R, Van Gorp S, Leerink M, Tadokoro T, Marsala S, Jamieson C, Marsala M, Ciacci JD. PMID: 29859175.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    17. Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. Sci Transl Med. 2018 05 09; 10(440). Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M. PMID: 29743351.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    18. The Current State of Rural Neurosurgical Practice: An International Perspective. J Neurosci Rural Pract. 2018 Jan-Mar; 9(1):123-131. Upadhyayula PS, Yue JK, Yang J, Birk HS, Ciacci JD. PMID: 29456356; PMCID: PMC5812136.
      View in: PubMed   Mentions: 10  
    19. Subacute Sclerosing Panencephalitis of the Brainstem as a Clinical Entity. Med Sci (Basel). 2017 Nov 07; 5(4). Upadhyayula PS, Yang J, Yue JK, Ciacci JD. PMID: 29112137; PMCID: PMC5753655.
      View in: PubMed   Mentions: 2     Fields:    
    20. Subpial Adeno-associated Virus 9 (AAV9) Vector Delivery in Adult Mice. J Vis Exp. 2017 07 13; (125). Tadokoro T, Miyanohara A, Navarro M, Kamizato K, Juhas S, Juhasova J, Marsala S, Platoshyn O, Curtis E, Gabel B, Ciacci J, Lukacova N, Bimbova K, Marsala M. PMID: 28745630; PMCID: PMC5612300.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    21. Risk factors for 30-day outcomes in elective anterior versus posterior cervical fusion: A matched cohort analysis. J Craniovertebr Junction Spine. 2017 Jul-Sep; 8(3):222-230. Yue JK, Upadhyayula PS, Deng H, Sing DC, Ciacci JD. PMID: 29021673; PMCID: PMC5634108.
      View in: PubMed   Mentions: 4  
    22. A matched cohort comparison of cervical disc arthroplasty versus anterior cervical discectomy and fusion: Evaluating perioperative outcomes. J Clin Neurosci. 2017 Sep; 43:235-239. Upadhyayula PS, Yue JK, Curtis EI, Hoshide R, Ciacci JD. PMID: 28511972.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Lateral mass screw stimulation thresholds in posterior cervical instrumentation surgery: a predictor of medial deviation. J Neurosurg Spine. 2017 Mar; 26(3):346-352. Wilson B, Curtis E, Hirshman B, Oygar A, Chen K, Gabel BC, Vaida F, Allison DW, Ciacci JD. PMID: 27935447; PMCID: PMC5485827.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Elective laminectomy and excision of the thoracic spine neoplasm: an evaluation of early outcomes. J Neurosurg Sci. 2019 Feb; 63(1):1-10. Upadhyayula PS, Yue JK, Curtis EI, Ciacci JD. PMID: 27879953.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. A Review of Stem Cell Therapy for Spinal Cord Injury: Large Animal Models and the Frontier in Humans. World Neurosurg. 2017 Feb; 98:438-443. Gabel BC, Curtis EI, Marsala M, Ciacci JD. PMID: 27876663.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    26. Depression After Spinal Surgery: A Comparative Analysis of the California Outcomes Database. Mayo Clin Proc. 2017 Jan; 92(1):88-97. Wilson BR, Tringale KR, Hirshman BR, Zhou T, Umlauf A, Taylor WR, Ciacci JD, Carter BS, Chen CC. PMID: 27836112; PMCID: PMC5426910.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    27. Intraspinal Pathology Associated With Pediatric Scoliosis: A Ten-year Review Analyzing the Effect of Neurosurgery on Scoliosis Curve Progression. Spine (Phila Pa 1976). 2016 Oct 15; 41(20):1600-1605. Jankowski PP, Bastrom T, Ciacci JD, Yaszay B, Levy ML, Newton PO. PMID: 26967125.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    28. Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. Mol Ther Methods Clin Dev. 2016; 3:16046. Miyanohara A, Kamizato K, Juhas S, Juhasova J, Navarro M, Marsala S, Lukacova N, Hruska-Plochan M, Curtis E, Gabel B, Ciacci J, Ahrens ET, Kaspar BK, Cleveland D, Marsala M. PMID: 27462649; PMCID: PMC4943453.
      View in: PubMed   Mentions: 16  
    29. The role of surgery for treatment of low back pain: insights from the randomized controlled Spine Patient Outcomes Research Trials. Surg Neurol Int. 2016; 7:38. Abraham P, Rennert RC, Martin JR, Ciacci J, Taylor W, Resnick D, Kasper E, Chen CC. PMID: 27127703; PMCID: PMC4838923.
      View in: PubMed   Mentions: 4  
    30. Thirty-Day Perioperative Outcomes in Spinal Fusion by Specialty Within the NSQIP Database. Spine (Phila Pa 1976). 2015 Jul 15; 40(14):1122-31. McCutcheon BA, Ciacci JD, Marcus LP, Noorbakhsh A, Gonda DD, McCafferty R, Taylor W, Chen CC, Carter BS, Chang DC. PMID: 25202939.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    31. Traumatic L5 Posterolateral Spondyloptosis: A Case Report and Review of the Literature. Cureus. 2015 Jun; 7(6):e277. Gabel BC, Curtis E, Gonda D, Ciacci J. PMID: 26180701; PMCID: PMC4494538.
      View in: PubMed   Mentions: 7  
    32. Pituitary tumor apoplexy in adolescents. World Neurosurg. 2015 Apr; 83(4):644-51. Jankowski PP, Crawford JR, Khanna P, Malicki DM, Ciacci JD, Levy ML. PMID: 25527883.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    33. Endometriosis of the conus medullaris causing cyclic radiculopathy. J Neurosurg Spine. 2014 Nov; 21(5):799-804. Steinberg JA, Gonda DD, Muller K, Ciacci JD. PMID: 25192376.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    34. Direct pressure on a pseudomeningocele resulting in intraoperative cerebral ischemia. Can J Anaesth. 2014 Jul; 61(7):656-9. Drummond JC, Ciacci JD, Lee RR. PMID: 24744102.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies. J Comp Neurol. 2014 Aug 15; 522(12):2784-801. Dolezalova D, Hruska-Plochan M, Bjarkam CR, Sørensen JC, Cunningham M, Weingarten D, Ciacci JD, Juhas S, Juhasova J, Motlik J, Hefferan MP, Hazel T, Johe K, Carromeu C, Muotri A, Bui J, Strnadel J, Marsala M. PMID: 24610493.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    36. A single institutional experience of conversion of non-tunneled to tunneled hemodialysis catheters: a comparison to de novo placement. Int Urol Nephrol. 2013 Dec; 45(6):1753-9. Bajaj SK, Ciacci J, Kirsch M, Ebersole JD. PMID: 23877664.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation. Stem Cell Res Ther. 2013 May 28; 4(3):57. van Gorp S, Leerink M, Kakinohana O, Platoshyn O, Santucci C, Galik J, Joosten EA, Hruska-Plochan M, Goldberg D, Marsala S, Johe K, Ciacci JD, Marsala M. PMID: 23710605; PMCID: PMC3706882.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    38. Survival and differentiation of human embryonic stem cell-derived neural precursors grafted spinally in spinal ischemia-injured rats or in naive immunosuppressed minipigs: a qualitative and quantitative study. Cell Transplant. 2012; 21(12):2603-19. Kakinohana O, Juhasova J, Juhas S, Motlik J, Platoshyn O, Galik J, Hefferan M, Yuan SH, Vidal JG, Carson CT, van Gorp S, Goldberg D, Leerink M, Lazar P, Marsala S, Miyanohara A, Keshavarzi S, Ciacci JD, Marsala M. PMID: 22889456.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    39. Chronic spinal compression model in minipigs: a systematic behavioral, qualitative, and quantitative neuropathological study. J Neurotrauma. 2012 Feb 10; 29(3):499-513. Navarro R, Juhas S, Keshavarzi S, Juhasova J, Motlik J, Johe K, Marsala S, Scadeng M, Lazar P, Tomori Z, Schulteis G, Beattie M, Ciacci JD, Marsala M. PMID: 22029501; PMCID: PMC3278823.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    40. Malignancies of the spinal cord. Adv Exp Med Biol. 2012; 760:101-13. Waters JD, Peran EM, Ciacci J. PMID: 23281516.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    41. HIF-1α potentiates mesenchymal stem cell mediated osteogenesis by coupling to angiogenesis. Neurosurgery. 2011 Oct; 69(4):N13-4. Jandial R, Chen MY, Ciacci J. PMID: 21900801.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    42. Expandable titanium cages for thoracolumbar vertebral body replacement: initial clinical experience and review of the literature. Am J Orthop (Belle Mead NJ). 2011 Mar; 40(3):E35-9. Keshavarzi S, Newman CB, Ciacci JD, Aryan HE. PMID: 21720606.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    43. Reluctant hydrocephalus. Neuropathology. 2010 Jun; 30(3):299-301. Keshavarzi S, Masoumi H, Jankowski P, Macdougall M, Lulic D, Hansen L, Ciacci JD. PMID: 20113401.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. Single-isocenter frameless intensity-modulated stereotactic radiosurgery for simultaneous treatment of multiple brain metastases: clinical experience. Int J Radiat Oncol Biol Phys. 2010 Sep 01; 78(1):91-7. Nath SK, Lawson JD, Simpson DR, Vanderspek L, Wang JZ, Alksne JF, Ciacci J, Mundt AJ, Murphy KT. PMID: 20096509.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    45. Stem cells in the treatment of stroke. Adv Exp Med Biol. 2010; 671:105-16. Urbaniak Hunter K, Yarbrough C, Ciacci J. PMID: 20455499.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    46. Gene- and cell-based approaches for neurodegenerative disease. Adv Exp Med Biol. 2010; 671:117-30. Urbaniak Hunter K, Yarbrough C, Ciacci J. PMID: 20455500.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    47. Stem cell horizons in intervertebral disc degeneration. Stem Cells Cloning. 2009 Jan 20; 1:31-9. Ciacci J, Ho A, Ames CP, Jandial R. PMID: 24198503; PMCID: PMC3781689.
      View in: PubMed   Mentions: 2  
    48. Lymphoma of the central nervous system in AIDS. Semin Neurol. 1999; 19(2):213-21. Ciacci JD, Tellez C, VonRoenn J, Levy RM. PMID: 10718542.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    49. Brainstem tethering in Dandy-Walker syndrome: a complication of cystoperitoneal shunting. Case report. J Neurosurg. 1995 Dec; 83(6):1072-4. Liu JC, Ciacci JD, George TM. PMID: 7490623.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    50. Clinical trial of Serratia marcescens extract and radiation therapy in patients with malignant astrocytoma. J Clin Oncol. 1993 Sep; 11(9):1746-50. Black KL, Ciacci JD, Ammirati M, Selch MT, Becker DP. PMID: 8394880.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsCTClinical Trials
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