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    Stuart Lipton

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentNeurosciences
    Address9500 Gilman Drive #0973
    CA La Jolla 92093
    Phone858-657-8540
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      Collapse Research 
      Collapse Research Activities and Funding
      S-Nitrosylation-Induced Posttranslational Modification and Aberrant Cell Signaling in Sporadic Alzheimer's Disease
      NIH/NIA R01AG056259Sep 30, 2017 - May 31, 2022
      Role: Principal Investigator
      Dynamic Interactions of the S-Nitrosoproteome in Type 2 Diabetes/Metabolic Syndrome and Alzheimer?s Disease
      NIH/NIA RF1AG057409Sep 15, 2017 - Apr 30, 2022
      Role: Principal Investigator
      Novel Proteomics Approach to HIV-Associated Neurocognitive Disorder & Drug Abuse
      NIH/NIDA DP1DA041722Apr 1, 2016 - Feb 28, 2021
      Role: Principal Investigator
      Modeling Parkinson's Disease with Isogenic hiPSC-Derived Dopaminergic Neurons
      NIH/NINDS R01NS086890Apr 1, 2014 - Jun 30, 2019
      Role: Principal Investigator
      Transnasal Delivery of Chemokine Analogs in mouse NeuroAIDS Models
      NIH/NINDS R21NS083415Sep 30, 2013 - Aug 31, 2015
      Role: Principal Investigator
      Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
      NIH/NINDS R21NS080799Sep 30, 2012 - Aug 31, 2014
      Role: Principal Investigator
      La Jolla Interdisciplinary Neuroscience Center Cores
      NIH/NINDS P30NS076411Sep 26, 2011 - Mar 31, 2017
      Role: Principal Investigator
      La Jolla-Parkinson's Disease Center Grant
      NIH/NIEHS P01ES016738Sep 15, 2008 - Jun 30, 2013
      Role: Principal Investigator
      La Jolla Interdisciplinary Neuroscience Center Cores
      NIH/NINDS P30NS057096Sep 22, 2006 - Aug 31, 2012
      Role: Principal Investigator
      Erythropoietin PLUS IGF-IN NEUROPROTECTION FROM AIDS
      NIH/NINDS R01NS047973Aug 15, 2004 - Aug 31, 2012
      Role: Principal Investigator
      S-Nitrosylation of Matrix Metalloproteinases in AIDS
      NIH/NINDS R01NS046994Jun 15, 2004 - Mar 31, 2009
      Role: Principal Investigator
      Caspase Cleavage of MEF2 Mediates Neuronal Apoptosis
      NIH/NINDS R01NS044326Aug 1, 2003 - Jul 31, 2009
      Role: Principal Investigator
      ERYTHROPOIETIN-INDUCED NEUROPROTECTION
      NIH/NINDS R01NS043242Jul 1, 2002 - Jun 30, 2007
      Role: Principal Investigator
      Chemokines and Macrophages in HIV Neuronal Apoptosis
      NIH/NINDS R01NS041207Sep 28, 2001 - Jul 31, 2005
      Role: Principal Investigator
      Cellular/Molecular Pathophysiology of Intellectual and Developmental Disabilities
      NIH/NICHD P01HD029587Sep 1, 1992 - Feb 28, 2017
      Role: Principal Investigator
      AIDS-Related Neurotoxicity and Novel NMDAR Antagonists
      NIH/NEI R01EY009024Feb 1, 1991 - Apr 30, 2011
      Role: Principal Investigator
      THY-1 AND NEURITE REGENERATION BY RETINAL GANGLION CELLS
      NIH/NEI R01EY006087Sep 30, 1986 - Jun 30, 1996
      Role: Principal Investigator
      RETINAL GANGLION CELLS: ION CHANNELS &TRANSMITTERS
      NIH/NEI R01EY005477Aug 1, 1984 - Aug 31, 2012
      Role: Principal Investigator
      COMMUNICATION AND REGENERATION OF CNS NEURITES
      NIH/NINDS K07NS000879Jul 1, 1984 - Jun 30, 1990
      Role: Principal Investigator
      Neurobiology of Disease -- Teaching Workshop
      NIH/NINDS R13NS020032Aug 1, 1983 - Oct 31, 2006
      Role: Co-Principal Investigator
      DEVELOPMENTAL NEUROLOGY
      NIH/NINDS T32NS007264Jan 1, 1983 - Dec 31, 1998
      Role: Co-Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Nagar S, Trudler D, McKercher SR, Piña-Crespo J, Nakanishi N, Okamoto SI, Lipton S. Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency. Invest Ophthalmol Vis Sci. 2017 Jul 01; 58(9):3741-3749. PMID: 28738418.
        View in: PubMed
      2. Nagar S, Noveral SM, Trudler D, Lopez KM, McKercher SR, Han X, Yates JR, Piña-Crespo JC, Nakanishi N, Satoh T, Okamoto SI, Lipton S. MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress. Proc Natl Acad Sci U S A. 2017 May 16; 114(20):E4048-E4056. PMID: 28461502.
        View in: PubMed
      3. Lipton S, Rezaie T, Nutter A, Lopez KM, Parker J, Kosaka K, Satoh T, McKercher SR, Masliah E, Nakanishi N. Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models. Cell Death Dis. 2016 Dec 01; 7(12):e2499. PMID: 27906174.
        View in: PubMed
      4. Sunico CR, Sultan A, Nakamura T, Dolatabadi N, Parker J, Shan B, Han X, Yates JR, Masliah E, Ambasudhan R, Nakanishi N, Lipton S. Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons. Proc Natl Acad Sci U S A. 2016 Nov 22; 113(47):E7564-E7571. PMID: 27821734.
        View in: PubMed
      5. Singec I, Crain AM, Hou J, Tobe BTD, Talantova M, Winquist AA, Doctor KS, Choy J, Huang X, La Monaca E, Horn DM, Wolf DA, Lipton S, Gutierrez GJ, Brill LM, Snyder EY. Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling. Stem Cell Reports. 2016 Sep 13; 7(3):527-542. PMID: 27569059.
        View in: PubMed
      6. Sanz-Blasco S, Piña-Crespo JC, Zhang X, McKercher SR, Lipton S. Levetiracetam inhibits oligomeric Aß-induced glutamate release from human astrocytes. Neuroreport. 2016 Jun 15; 27(9):705-9. PMID: 27183239; PMCID: PMC4874889 [Available on 06/15/17].
      7. Lipton S, Nordstedt C. Partnering with Big Pharma-What Academics Need to Know. Cell. 2016 Apr 21; 165(3):512-5. PMID: 27104971.
        View in: PubMed
      8. Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton S, Pilz RB, Boss GR. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016 Feb 15; 6:20831. PMID: 26877209; PMCID: PMC4753484.
      9. Akhtar MW, Sanz-Blasco S, Dolatabadi N, Parker J, Chon K, Lee MS, Soussou W, McKercher SR, Ambasudhan R, Nakamura T, Lipton S. Elevated glucose and oligomeric ß-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nat Commun. 2016 Jan 08; 7:10242. PMID: 26743041; PMCID: PMC4729876.
      10. Nakamura T, Lipton S. Protein S-Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases. Trends Pharmacol Sci. 2016 Jan; 37(1):73-84. PMID: 26707925; PMCID: PMC4698225 [Available on 01/01/17].
      11. Takahashi H, Xia P, Cui J, Talantova M, Bodhinathan K, Li W, Saleem S, Holland EA, Tong G, Piña-Crespo J, Zhang D, Nakanishi N, Larrick JW, McKercher SR, Nakamura T, Wang Y, Lipton S. Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease. Sci Rep. 2015 Oct 19; 5:14781. PMID: 26477507; PMCID: PMC4609936.
      12. Nakanishi N, Kang YJ, Tu S, McKercher SR, Masliah E, Lipton S. Differential Effects of Pharmacologic and Genetic Modulation of NMDA Receptor Activity on HIV/gp120-Induced Neuronal Damage in an In Vivo Mouse Model. J Mol Neurosci. 2016 Jan; 58(1):59-65. PMID: 26374431; PMCID: PMC4821006.
      13. Satoh T, Stalder R, McKercher SR, Williamson RE, Roth GP, Lipton S. Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules is Regulated by Electrochemical Oxidation Potential. ASN Neuro. 2015 Jul-Aug; 7(4). PMID: 26243592; PMCID: PMC4550314.
      14. Nakamura T, Lipton S. Nitrosative Stress in the Nervous System: Guidelines for Designing Experimental Strategies to Study Protein S-Nitrosylation. Neurochem Res. 2016 Mar; 41(3):510-4. PMID: 26118537; PMCID: PMC4695327.
      15. Nakamura T, Prikhodko OA, Pirie E, Nagar S, Akhtar MW, Oh CK, McKercher SR, Ambasudhan R, Okamoto S, Lipton S. Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases. Neurobiol Dis. 2015 Dec; 84:99-108. PMID: 25796565; PMCID: PMC4575233 [Available on 12/01/16].
      16. Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T, Ambasudhan R, McKercher SR, Masliah E, Lipton S. Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid. J Neurochem. 2015 Jun; 133(6):898-908. PMID: 25692407; PMCID: PMC4465065.
      17. Chan SF, Huang X, McKercher SR, Zaidi R, Okamoto SI, Nakanishi N, Lipton S. Transcriptional profiling of MEF2-regulated genes in human neural progenitor cells derived from embryonic stem cells. Genom Data. 2015 Mar 01; 3:24-27. PMID: 25485232.
        View in: PubMed
      18. Okamoto S, Lipton S. S-Nitrosylation in neurogenesis and neuronal development. Biochim Biophys Acta. 2015 Aug; 1850(8):1588-93. PMID: 25527866; PMCID: PMC4441575.
      19. Tu S, Okamoto S, Lipton S, Xu H. Oligomeric Aß-induced synaptic dysfunction in Alzheimer's disease. Mol Neurodegener. 2014 Nov 14; 9:48. PMID: 25394486; PMCID: PMC4237769.
      20. Lipton S, Stevens CF. Stephen F. Heinemann: 1939-2014. Cell. 2014 Oct 09; 159(2):231-2. PMID: 25436266.
        View in: PubMed
      21. Okamoto S, Nakamura T, Cieplak P, Chan SF, Kalashnikova E, Liao L, Saleem S, Han X, Clemente A, Nutter A, Sances S, Brechtel C, Haus D, Haun F, Sanz-Blasco S, Huang X, Li H, Zaremba JD, Cui J, Gu Z, Nikzad R, Harrop A, McKercher SR, Godzik A, Yates JR, Lipton S. S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death. Cell Rep. 2014 Jul 10; 8(1):217-28. PMID: 25001280; PMCID: PMC4114155.
      22. Ambasudhan R, Dolatabadi N, Nutter A, Masliah E, Mckercher SR, Lipton S. Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells. J Comp Neurol. 2014 Aug 15; 522(12):2845-56. PMID: 24756727; PMCID: PMC4388243.
      23. Molokanova E, Akhtar MW, Sanz-Blasco S, Tu S, Piña-Crespo JC, McKercher SR, Lipton S. Differential effects of synaptic and extrasynaptic NMDA receptors on Aß-induced nitric oxide production in cerebrocortical neurons. J Neurosci. 2014 Apr 02; 34(14):5023-8. PMID: 24695719; PMCID: PMC3972726.
      24. Chan SF, Sances S, Brill LM, Okamoto S, Zaidi R, McKercher SR, Akhtar MW, Nakanishi N, Lipton S. ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage. J Neurosci. 2014 Mar 26; 34(13):4640-53. PMID: 24672010; PMCID: PMC3965787.
      25. Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, McKercher SR, Cho YS, Lipton S, Kim J, Ding S. Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Res. 2014 Jan; 24(1):126-9. PMID: 24296783; PMCID: PMC3879704.
      26. Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, Zhang Y, Han X, Nakamura T, Masliah E, Yates JR, Nakanishi N, Andreyev AY, Okamoto S, Jaenisch R, Ambasudhan R, Lipton S. Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1a transcription. Cell. 2013 Dec 05; 155(6):1351-64. PMID: 24290359; PMCID: PMC4028128.
      27. Satoh T, McKercher SR, Lipton S. Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic Biol Med. 2014 Jan; 66:45-57. PMID: 24262357.
        View in: PubMed
      28. Nakanishi N, Ryan SD, Zhang X, Khan A, Holland T, Cho EG, Huang X, Liao FF, Xu H, Lipton S, Tu S. Synaptic protein a1-takusan mitigates amyloid-ß-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. J Neurosci. 2013 Aug 28; 33(35):14170-83. PMID: 23986251; PMCID: PMC3756761.
      29. Sunico CR, Nakamura T, Rockenstein E, Mante M, Adame A, Chan SF, Newmeyer TF, Masliah E, Nakanishi N, Lipton S. S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease. Mol Neurodegener. 2013 Aug 28; 8:29. PMID: 23985028; PMCID: PMC3765907.
      30. Satoh T, McKercher SR, Lipton S. Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic Biol Med. 2013 Dec; 65:645-57. PMID: 23892355; PMCID: PMC3859717.
      31. Haun F, Nakamura T, Shiu AD, Cho DH, Tsunemi T, Holland EA, La Spada AR, Lipton S. S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease. Antioxid Redox Signal. 2013 Oct 10; 19(11):1173-84. PMID: 23641925; PMCID: PMC3785802.
      32. Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton S. Aß induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):E2518-27. PMID: 23776240; PMCID: PMC3704025.
      33. Nakamura T, Tu S, Akhtar MW, Sunico CR, Okamoto S, Lipton S. Aberrant protein s-nitrosylation in neurodegenerative diseases. Neuron. 2013 May 22; 78(4):596-614. PMID: 23719160; PMCID: PMC3712898.
      34. Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton S, Hong W, Xu H. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr; 19(4):473-80. PMID: 23524343; PMCID: PMC3911880.
      35. Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton S. S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3137-42. PMID: 23382182; PMCID: PMC3581884.
      36. Haun F, Nakamura T, Lipton S. Dysfunctional Mitochondrial Dynamics in the Pathophysiology of Neurodegenerative Diseases. J Cell Death. 2013; 6:27-35. PMID: 24587691.
        View in: PubMed
      37. Rezaie T, McKercher SR, Kosaka K, Seki M, Wheeler L, Viswanath V, Chun T, Joshi R, Valencia M, Sasaki S, Tozawa T, Satoh T, Lipton S. Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2012 Nov 27; 53(12):7847-54. PMID: 23081978; PMCID: PMC3508754.
      38. Piña-Crespo JC, Talantova M, Cho EG, Soussou W, Dolatabadi N, Ryan SD, Ambasudhan R, McKercher S, Deisseroth K, Lipton S. High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons. J Neurosci. 2012 Nov 07; 32(45):15837-42. PMID: 23136422; PMCID: PMC3513396.
      39. Akhtar MW, Sunico CR, Nakamura T, Lipton S. Redox Regulation of Protein Function via Cysteine S-Nitrosylation and Its Relevance to Neurodegenerative Diseases. Int J Cell Biol. 2012; 2012:463756. PMID: 22956959; PMCID: PMC3431077.
      40. Qu J, Nakamura T, Holland EA, McKercher SR, Lipton S. S-nitrosylation of Cdk5: potential implications in amyloid-ß-related neurotoxicity in Alzheimer disease. Prion. 2012 Sep-Oct; 6(4):364-70. PMID: 22874667; PMCID: PMC3609065.
      41. Nakamura T, Lipton S. Emerging role of protein-protein transnitrosylation in cell signaling pathways. Antioxid Redox Signal. 2013 Jan 20; 18(3):239-49. PMID: 22657837; PMCID: PMC3518546.
      42. Nakamura T, Cho DH, Lipton S. Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases. Exp Neurol. 2012 Nov; 238(1):12-21. PMID: 22771760; PMCID: PMC3645978.
      43. Banerjee S, Liao L, Russo R, Nakamura T, McKercher SR, Okamoto S, Haun F, Nikzad R, Zaidi R, Holland E, Eroshkin A, Yates JR, Lipton S. Isobaric tagging-based quantification by mass spectrometry of differentially regulated proteins in synaptosomes of HIV/gp120 transgenic mice: implications for HIV-associated neurodegeneration. Exp Neurol. 2012 Aug; 236(2):298-306. PMID: 22575597; PMCID: PMC3392539.
      44. Cho EG, Zaremba JD, McKercher SR, Talantova M, Tu S, Masliah E, Chan SF, Nakanishi N, Terskikh A, Lipton S. MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model. PLoS One. 2011; 6(8):e24027. PMID: 21901155; PMCID: PMC3162026.
      45. Qu J, Nakamura T, Cao G, Holland EA, McKercher SR, Lipton S. S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14330-5. PMID: 21844361; PMCID: PMC3161554.
      46. Ambasudhan R, Talantova M, Coleman R, Yuan X, Zhu S, Lipton S, Ding S. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell. 2011 Aug 05; 9(2):113-8. PMID: 21802386; PMCID: PMC4567246.
      47. Li W, Sun W, Zhang Y, Wei W, Ambasudhan R, Xia P, Talantova M, Lin T, Kim J, Wang X, Kim WR, Lipton S, Zhang K, Ding S. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8299-304. PMID: 21525408; PMCID: PMC3100988.
      48. Kim J, Efe JA, Zhu S, Talantova M, Yuan X, Wang S, Lipton S, Zhang K, Ding S. Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7838-43. PMID: 21521790; PMCID: PMC3093517.
      49. Nakamura T, Lipton S. S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Antioxid Redox Signal. 2011 Apr 15; 14(8):1479-92. PMID: 20812868; PMCID: PMC3061195.
      50. Krajewska M, Xu L, Xu W, Krajewski S, Kress CL, Cui J, Yang L, Irie F, Yamaguchi Y, Lipton S, Reed JC. Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury. Brain Res. 2011 Jan 25; 1370:227-37. PMID: 21075086; PMCID: PMC3019258.
      51. Nakamura T, Lipton S. Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases. Apoptosis. 2010 Nov; 15(11):1354-63. PMID: 20177970; PMCID: PMC2978885.
      52. Kang YJ, Digicaylioglu M, Russo R, Kaul M, Achim CL, Fletcher L, Masliah E, Lipton S. Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders. Ann Neurol. 2010 Sep; 68(3):342-52. PMID: 20818790; PMCID: PMC3733362.
      53. Piña-Crespo JC, Talantova M, Micu I, States B, Chen HS, Tu S, Nakanishi N, Tong G, Zhang D, Heinemann SF, Zamponi GW, Stys PK, Lipton S. Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits. J Neurosci. 2010 Aug 25; 30(34):11501-5. PMID: 20739572; PMCID: PMC2941801.
      54. Xia P, Chen HS, Zhang D, Lipton S. Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses. J Neurosci. 2010 Aug 18; 30(33):11246-50. PMID: 20720132; PMCID: PMC2932667.
      55. Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR, Lipton S. Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Mol Cell. 2010 Jul 30; 39(2):184-95. PMID: 20670888; PMCID: PMC2924818.
      56. Cho DH, Nakamura T, Lipton S. Mitochondrial dynamics in cell death and neurodegeneration. Cell Mol Life Sci. 2010 Oct; 67(20):3435-47. PMID: 20577776.
        View in: PubMed
      57. Nakamura T, Cieplak P, Cho DH, Godzik A, Lipton S. S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration. Mitochondrion. 2010 Aug; 10(5):573-8. PMID: 20447471; PMCID: PMC2918703.
      58. Nakamura T, Lipton S. Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies. Cell Calcium. 2010 Feb; 47(2):190-7. PMID: 20060165; PMCID: PMC2875138.
      59. Okamoto S, Pouladi MA, Talantova M, Yao D, Xia P, Ehrnhoefer DE, Zaidi R, Clemente A, Kaul M, Graham RK, Zhang D, Vincent Chen HS, Tong G, Hayden MR, Lipton S. Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat Med. 2009 Dec; 15(12):1407-13. PMID: 19915593; PMCID: PMC2789858.
      60. Seki M, Soussou W, Manabe S, Lipton S. Protection of retinal ganglion cells by caspase substrate-binding peptide IQACRG from N-methyl-D-aspartate receptor-mediated excitotoxicity. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):1198-207. PMID: 19815732; PMCID: PMC2868456.
      61. Nakamura T, Lipton S. According to GOSPEL: filling in the GAP(DH) of NO-mediated neurotoxicity. Neuron. 2009 Jul 16; 63(1):3-6. PMID: 19607786.
        View in: PubMed
      62. Nakanishi N, Tu S, Shin Y, Cui J, Kurokawa T, Zhang D, Chen HS, Tong G, Lipton S. Neuroprotection by the NR3A subunit of the NMDA receptor. J Neurosci. 2009 Apr 22; 29(16):5260-5. PMID: 19386922; PMCID: PMC2703294.
      63. Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton S. S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science. 2009 Apr 03; 324(5923):102-5. PMID: 19342591; PMCID: PMC2823371.
      64. Nakamura T, Lipton S. Cell death: protein misfolding and neurodegenerative diseases. Apoptosis. 2009 Apr; 14(4):455-68. PMID: 19130231.
        View in: PubMed
      65. Li H, Radford JC, Ragusa MJ, Shea KL, McKercher SR, Zaremba JD, Soussou W, Nie Z, Kang YJ, Nakanishi N, Okamoto S, Roberts AJ, Schwarz JJ, Lipton S. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9397-402. PMID: 18599437; PMCID: PMC2453715.
      66. Li Z, McKercher SR, Cui J, Nie Z, Soussou W, Roberts AJ, Sallmen T, Lipton JH, Talantova M, Okamoto S, Lipton S. Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. J Neurosci. 2008 Jun 25; 28(26):6557-68. PMID: 18579729; PMCID: PMC2679693.
      67. Seki M, Lipton S. Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma. Prog Brain Res. 2008; 173:495-510. PMID: 18929130.
        View in: PubMed
      68. Nakamura T, Lipton S. Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases. Antioxid Redox Signal. 2008 Jan; 10(1):87-101. PMID: 17961071.
        View in: PubMed
      69. Fang J, Nakamura T, Cho DH, Gu Z, Lipton S. S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18742-7. PMID: 18003920; PMCID: PMC2141847.
      70. Tong G, Takahashi H, Tu S, Shin Y, Talantova M, Zago W, Xia P, Nie Z, Goetz T, Zhang D, Lipton S, Nakanishi N. Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons. J Neurophysiol. 2008 Jan; 99(1):122-32. PMID: 18003876; PMCID: PMC4586267.
      71. Alirezaei M, Watry DD, Flynn CF, Kiosses WB, Masliah E, Williams BR, Kaul M, Lipton S, Fox HS. Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. J Neurosci. 2007 Oct 10; 27(41):11047-55. PMID: 17928446.
        View in: PubMed
      72. Lipton S. Pathologically activated therapeutics for neuroprotection. Nat Rev Neurosci. 2007 Oct; 8(10):803-8. PMID: 17882256.
        View in: PubMed
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