Stuart Lipton

Title(s)Associate Physician Diplomate, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Leadership in AD/ADRD Drug Discovery
    NIH R35AG071734Sep 1, 2021 - Aug 31, 2026
    Role: Principal Investigator
    Pro-Electrophilic Drugs PEDs for Alzheimer's Disease
    NIH R56AG065372Sep 15, 2020 - May 31, 2022
    Role: Principal Investigator
    S-Nitrosylation-Induced Posttranslational Modification and Aberrant Cell Signaling in Sporadic Alzheimer's Disease
    NIH R01AG056259Sep 30, 2017 - May 31, 2022
    Role: Principal Investigator
    Dynamic Interactions of the S-Nitrosoproteome in Type 2 Diabetes/Metabolic Syndrome and Alzheimer?s Disease
    NIH RF1AG057409Sep 15, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Novel Proteomics Approach to HIV-Associated Neurocognitive Disorder & Drug Abuse
    NIH DP1DA041722Apr 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Modeling Parkinson's Disease with Isogenic hiPSC-Derived Dopaminergic Neurons
    NIH R01NS086890Apr 1, 2014 - Jun 30, 2020
    Role: Principal Investigator
    Transnasal Delivery of Chemokine Analogs in mouse NeuroAIDS Models
    NIH R21NS083415Sep 30, 2013 - Aug 31, 2015
    Role: Principal Investigator
    Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    NIH R21NS080799Sep 30, 2012 - Aug 31, 2015
    Role: Principal Investigator
    La Jolla Interdisciplinary Neuroscience Center Cores
    NIH P30NS076411Sep 26, 2011 - Mar 31, 2018
    Role: Principal Investigator
    La Jolla-Parkinson's Disease Center Grant
    NIH P01ES016738Sep 15, 2008 - Jun 30, 2013
    Role: Principal Investigator
    La Jolla Interdisciplinary Neuroscience Center Cores
    NIH P30NS057096Sep 22, 2006 - Aug 31, 2012
    Role: Principal Investigator
    Erythropoietin PLUS IGF-IN NEUROPROTECTION FROM AIDS
    NIH R01NS047973Aug 15, 2004 - Aug 31, 2012
    Role: Principal Investigator
    S-Nitrosylation of Matrix Metalloproteinases in AIDS
    NIH R01NS046994Jun 15, 2004 - Mar 31, 2009
    Role: Principal Investigator
    Caspase Cleavage of MEF2 Mediates Neuronal Apoptosis
    NIH R01NS044326Aug 1, 2003 - Jul 31, 2009
    Role: Principal Investigator
    ERYTHROPOIETIN-INDUCED NEUROPROTECTION
    NIH R01NS043242Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator
    Chemokines and Macrophages in HIV Neuronal Apoptosis
    NIH R01NS041207Sep 28, 2001 - Jul 31, 2005
    Role: Principal Investigator
    Cellular/Molecular Pathophysiology of Intellectual and Developmental Disabilities
    NIH P01HD029587Sep 1, 1992 - Feb 28, 2018
    Role: Principal Investigator
    AIDS-Related Neurotoxicity and Novel NMDAR Antagonists
    NIH R01EY009024Feb 1, 1991 - Apr 30, 2011
    Role: Principal Investigator
    THY-1 AND NEURITE REGENERATION BY RETINAL GANGLION CELLS
    NIH R01EY006087Sep 30, 1986 - Jun 30, 1996
    Role: Principal Investigator
    RETINAL GANGLION CELLS: ION CHANNELS &TRANSMITTERS
    NIH R01EY005477Aug 1, 1984 - Aug 31, 2012
    Role: Principal Investigator
    COMMUNICATION AND REGENERATION OF CNS NEURITES
    NIH K07NS000879Jul 1, 1984 - Jun 30, 1990
    Role: Principal Investigator
    Neurobiology of Disease -- Teaching Workshop
    NIH R13NS020032Aug 1, 1983 - Oct 31, 2006
    Role: Co-Principal Investigator
    DEVELOPMENTAL NEUROLOGY
    NIH T32NS007264Jan 1, 1983 - Dec 31, 1998
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Metabolic Bypass Rescues Aberrant S-nitrosylation-Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons. Adv Sci (Weinh). 2024 Mar; 11(12):e2306469. Andreyev AY, Yang H, Doulias PT, Dolatabadi N, Zhang X, Luevanos M, Blanco M, Baal C, Putra I, Nakamura T, Ischiropoulos H, Tannenbaum SR, Lipton SA. PMID: 38235614; PMCID: PMC10966553.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. Enzymatic and non-enzymatic transnitrosylation: "SCAN"ning the SNO-proteome. Mol Cell. 2024 Jan 18; 84(2):191-193. Nakamura T, Lipton SA. PMID: 38242098.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Reply to: Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection. Nat Chem Biol. 2023 Nov; 19(11):1306-1308. Oh CK, Piña-Crespo J, Talantova M, Carnevale LN, Stoneham C, Lewinski M, Guatelli J, Lipton SA. PMID: 37798355.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression. Neuropharmacology. 2023 Dec 15; 241:109729. Tse WS, Pochwat B, Szewczyk B, Misztak P, Bobula B, Tokarski K, Worch R, Czarnota-Bojarska M, Lipton SA, Zareba-Koziol M, Bijata M, Wlodarczyk J. PMID: 37797736.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons. Cell Chem Biol. 2023 08 17; 30(8):965-975.e6. Doulias PT, Yang H, Andreyev AY, Dolatabadi N, Scott H, K Raspur C, Patel PR, Nakamura T, Tannenbaum SR, Ischiropoulos H, Lipton SA. PMID: 37478858; PMCID: PMC10530441.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. 2023 05; 30(5):1097-1154. Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JHM, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CMP, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L. PMID: 37100955; PMCID: PMC10130819.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    7. Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis. Nat Commun. 2023 02 04; 14(1):621. Okuda K, Nakahara K, Ito A, Iijima Y, Nomura R, Kumar A, Fujikawa K, Adachi K, Shimada Y, Fujio S, Yamamoto R, Takasugi N, Onuma K, Osaki M, Okada F, Ukegawa T, Takeuchi Y, Yasui N, Yamashita A, Marusawa H, Matsushita Y, Katagiri T, Shibata T, Uchida K, Niu SY, Lang NB, Nakamura T, Zhang KYJ, Lipton SA, Uehara T. PMID: 36739439; PMCID: PMC9899281.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Aberrant protein S-nitrosylation contributes to hyperexcitability-induced synaptic damage in Alzheimer's disease: Mechanistic insights and potential therapies. Front Neural Circuits. 2023; 17:1099467. Ghatak S, Nakamura T, Lipton SA. PMID: 36817649; PMCID: PMC9932935.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Mechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S-nitrosylation of C3. Sci Adv. 2022 12 14; 8(50):eade0764. Yang H, Oh CK, Amal H, Wishnok JS, Lewis S, Schahrer E, Trudler D, Nakamura T, Tannenbaum SR, Lipton SA. PMID: 36516243; PMCID: PMC9750152.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    10. Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. EMBO J. 2022 11 17; 41(22):e111952. Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-Gonzalez C, Sabusap CM, Bermedo-Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi SP, Lipton SA, Kennedy BK, Henriquez JP, Cárdenas JC, Plate L, Palacios AG, Hetz C. PMID: 36314651; PMCID: PMC9670206.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    11. Hidden networks of aberrant protein transnitrosylation contribute to synapse loss in Alzheimer's disease. Free Radic Biol Med. 2022 11 20; 193(Pt 1):171-176. Lipton SA. PMID: 36243209.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection. Nat Chem Biol. 2023 03; 19(3):275-283. Oh CK, Nakamura T, Beutler N, Zhang X, Piña-Crespo J, Talantova M, Ghatak S, Trudler D, Carnevale LN, McKercher SR, Bakowski MA, Diedrich JK, Roberts AJ, Woods AK, Chi V, Gupta AK, Rosenfeld MA, Kearns FL, Casalino L, Shaabani N, Liu H, Wilson IA, Amaro RE, Burton DR, Yates JR, Becker C, Rogers TF, Chatterjee AK, Lipton SA. PMID: 36175661; PMCID: PMC10127945.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    13. Towards development of disease-modifying therapy for Alzheimer's disease using redox chemical biology pathways. Curr Opin Pharmacol. 2022 10; 66:102267. Lipton SA. PMID: 35870288; PMCID: PMC9509422.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. Inhibition of autophagic flux by S-nitrosylation of SQSTM1/p62 promotes neuronal secretion and cell-to-cell transmission of SNCA/α-synuclein in Parkinson disease and Lewy body dementia. Autophagy Rep. 2022; 1(1):223-225. Oh CK, Nakamura T, Lipton SA. PMID: 38098743; PMCID: PMC10721282.
      View in: PubMed   Mentions:
    15. S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders. Cell Death Differ. 2022 11; 29(11):2137-2150. Kim KR, Cho EJ, Eom JW, Oh SS, Nakamura T, Oh CK, Lipton SA, Kim YH. PMID: 35462559; PMCID: PMC9613756.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    16. Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection. bioRxiv. 2022 Apr 05. Oh CK, Nakamura T, Beutler N, Zhang X, Piña-Crespo J, Talantova M, Ghatak S, Trudler D, Carnevale LN, McKercher SR, Bakowski MA, Diedrich JK, Roberts AJ, Woods AK, Chi V, Gupta AK, Rosenfeld MA, Kearns FL, Casalino L, Shaabani N, Liu H, Wilson IA, Amaro RE, Burton DR, Yates JR, Becker C, Rogers TF, Chatterjee AK, Lipton SA. PMID: 35411336; PMCID: PMC8996617.
      View in: PubMed   Mentions:
    17. S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia. J Neurosci. 2022 04 06; 42(14):3011-3024. Oh CK, Dolatabadi N, Cieplak P, Diaz-Meco MT, Moscat J, Nolan JP, Nakamura T, Lipton SA. PMID: 35169022; PMCID: PMC8985870.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    18. Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome. Antioxidants (Basel). 2022 Jan 06; 11(1). Satoh T, Trudler D, Oh CK, Lipton SA. PMID: 35052628; PMCID: PMC8772720.
      View in: PubMed   Mentions: 29  
    19. Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases. Int J Mol Sci. 2021 Jul 30; 22(15). Trudler D, Ghatak S, Lipton SA. PMID: 34360966; PMCID: PMC8347370.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    20. Protein S-nitrosylation and oxidation contribute to protein misfolding in neurodegeneration. Free Radic Biol Med. 2021 08 20; 172:562-577. Nakamura T, Oh CK, Zhang X, Lipton SA. PMID: 34224817; PMCID: PMC8579830.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    21. Protein Transnitrosylation Signaling Networks Contribute to Inflammaging and Neurodegenerative Disorders. Antioxid Redox Signal. 2021 09 01; 35(7):531-550. Nakamura T, Oh CK, Zhang X, Tannenbaum SR, Lipton SA. PMID: 33957758; PMCID: PMC8388249.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    22. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021 07 13; 54(7):1463-1477.e11. Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E. PMID: 34115964; PMCID: PMC8189765.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    23. Correction to: TCA cycle metabolic compromise due to an aberrant S‑nitrosoproteome in HIV‑associated neurocognitive disorder with methamphetamine use. J Neurovirol. 2021 Jun; 27(3):379. Doulias PT, Nakamura T, Scott H, McKercher SR, Sultan A, Deal A, Albertolle M, Ischiropoulos H, Lipton SA. PMID: 33942273.
      View in: PubMed   Mentions:    Fields:    
    24. TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use. J Neurovirol. 2021 06; 27(3):367-378. Doulias PT, Nakamura T, Scott H, McKercher SR, Sultan A, Deal A, Albertolle M, Ischiropoulos H, Lipton SA. PMID: 33876414; PMCID: PMC8477648.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    25. Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proc Natl Acad Sci U S A. 2021 04 13; 118(15). Trudler D, Nazor KL, Eisele YS, Grabauskas T, Dolatabadi N, Parker J, Sultan A, Zhong Z, Goodwin MS, Levites Y, Golde TE, Kelly JW, Sierks MR, Schork NJ, Karin M, Ambasudhan R, Lipton SA. PMID: 33833060; PMCID: PMC8054017.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    26. S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD. Proc Natl Acad Sci U S A. 2021 03 16; 118(11). Pirie E, Oh CK, Zhang X, Han X, Cieplak P, Scott HR, Deal AK, Ghatak S, Martinez FJ, Yeo GW, Yates JR, Nakamura T, Lipton SA. PMID: 33692125; PMCID: PMC7980404.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    27. α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss. J Neurosci. 2021 03 10; 41(10):2264-2273. Trudler D, Sanz-Blasco S, Eisele YS, Ghatak S, Bodhinathan K, Akhtar MW, Lynch WP, Piña-Crespo JC, Talantova M, Kelly JW, Lipton SA. PMID: 33483428; PMCID: PMC8018774.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    28. Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer's disease. Science. 2021 01 15; 371(6526). Nakamura T, Oh CK, Liao L, Zhang X, Lopez KM, Gibbs D, Deal AK, Scott HR, Spencer B, Masliah E, Rissman RA, Yates JR, Lipton SA. PMID: 33273062; PMCID: PMC8091809.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    29. Novel Therapeutic Approach for Excitatory/Inhibitory Imbalance in Neurodevelopmental and Neurodegenerative Diseases. Annu Rev Pharmacol Toxicol. 2021 01 06; 61:701-721. Ghatak S, Talantova M, McKercher SR, Lipton SA. PMID: 32997602.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    30. NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models. Mol Psychiatry. 2021 10; 26(10):5751-5765. Ghatak S, Dolatabadi N, Gao R, Wu Y, Scott H, Trudler D, Sultan A, Ambasudhan R, Nakamura T, Masliah E, Talantova M, Voytek B, Lipton SA. PMID: 32467645; PMCID: PMC7704704.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    31. Nitric Oxide-Dependent Protein Post-Translational Modifications Impair Mitochondrial Function and Metabolism to Contribute to Neurodegenerative Diseases. Antioxid Redox Signal. 2020 04 20; 32(12):817-833. Nakamura T, Lipton SA. PMID: 31657228; PMCID: PMC7074890.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    32. Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls. Elife. 2019 11 29; 8. Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA. PMID: 31782729; PMCID: PMC6905854.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    33. NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model. Neurobiol Dis. 2019 07; 127:390-397. Okamoto SI, Prikhodko O, Pina-Crespo J, Adame A, McKercher SR, Brill LM, Nakanishi N, Oh CK, Nakamura T, Masliah E, Lipton SA. PMID: 30928642; PMCID: PMC6760869.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    34. Novel Direct Conversion of Microglia to Neurons. Trends Mol Med. 2019 02; 25(2):72-74. Trudler D, Lipton SA. PMID: 30611669; PMCID: PMC6384091.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    35. The mouse as a model for neuropsychiatric drug development. Curr Biol. 2018 09 10; 28(17):R909-R914. Howe JR, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ. PMID: 30205056; PMCID: PMC8163022.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    36. Publisher Correction: Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease. Nat Commun. 2018 03 09; 9(1):1070. Mann AP, Scodeller P, Hussain S, Braun GB, Mölder T, Toome K, Ambasudhan R, Teesalu T, Lipton SA, Ruoslahti E. PMID: 29523838; PMCID: PMC5844894.
      View in: PubMed   Mentions:    Fields:    
    37. Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nat Commun. 2018 02 26; 9(1):817. Ryan T, Bamm VV, Stykel MG, Coackley CL, Humphries KM, Jamieson-Williams R, Ambasudhan R, Mosser DD, Lipton SA, Harauz G, Ryan SD. PMID: 29483518; PMCID: PMC5827019.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
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    161. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J. 2006 Aug 23; 25(16):3900-11. Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gräber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, Ellisman MH, Perkins GA, Bossy-Wetzel E. PMID: 16874299; PMCID: PMC1553198.
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    162. Mechanisms of neuronal injury and death in HIV-1 associated dementia. Curr HIV Res. 2006 Jul; 4(3):307-18. Kaul M, Lipton SA. PMID: 16842083.
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    163. The pharmacology of aminoadamantane nitrates. Curr Alzheimer Res. 2006 Jul; 3(3):201-4. Wang Y, Eu J, Washburn M, Gong T, Chen HS, James WL, Lipton SA, Stamler JS, Went GT, Porter S. PMID: 16842096.
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    164. The chemical biology of clinically tolerated NMDA receptor antagonists. J Neurochem. 2006 Jun; 97(6):1611-26. Chen HS, Lipton SA. PMID: 16805772.
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    165. Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS. J Neuroimmune Pharmacol. 2006 Jun; 1(2):138-51. Kaul M, Lipton SA. PMID: 18040780.
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    166. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature. 2006 May 25; 441(7092):513-7. Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA. PMID: 16724068.
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    167. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nat Med. 2006 May; 12(5):526-33. Sheng G, Chang GQ, Lin JY, Yu ZX, Fang ZH, Rong J, Lipton SA, Li SH, Tong G, Leibowitz SF, Li XJ. PMID: 16604089.
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    168. NMDA receptors, glial cells, and clinical medicine. Neuron. 2006 Apr 06; 50(1):9-11. Lipton SA. PMID: 16600850.
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    169. Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat Rev Drug Discov. 2006 Feb; 5(2):160-70. Lipton SA. PMID: 16424917.
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    170. Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. J Neurosci. 2005 Dec 14; 25(50):11542-52. Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF. PMID: 16354912; PMCID: PMC6726015.
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    171. Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4747-53. Manabe S, Gu Z, Lipton SA. PMID: 16303975.
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    172. OPA1 expression in the normal rat retina and optic nerve. J Comp Neurol. 2005 Jul 18; 488(1):1-10. Ju WK, Misaka T, Kushnareva Y, Nakagomi S, Agarwal N, Kubo Y, Lipton SA, Bossy-Wetzel E. PMID: 15912498; PMCID: PMC1350956.
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    173. A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J Neurosci. 2005 Jul 06; 25(27):6401-8. Gu Z, Cui J, Brown S, Fridman R, Mobashery S, Strongin AY, Lipton SA. PMID: 16000631; PMCID: PMC6725288.
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    174. Comment on "S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function". Science. 2005 Jun 24; 308(5730):1870; author reply 1870. Lipton SA, Nakamura T, Yao D, Shi ZQ, Uehara T, Gu Z. PMID: 15976289.
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    175. Paradigm shift in NMDA receptor drug development. Expert Opin Ther Targets. 2005 Jun; 9(3):427-9. Lipton SA, Chen HS. PMID: 15948664.
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    176. Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels. J Pharmacol Exp Ther. 2005 Sep; 314(3):961-71. Chen HS, Lipton SA. PMID: 15901795.
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    177. A developmental influence of the N-methyl-D-aspartate receptor NR3A subunit on prepulse inhibition of startle. Biol Psychiatry. 2005 May 15; 57(10):1147-52. Brody SA, Nakanishi N, Tu S, Lipton SA, Geyer MA. PMID: 15866554.
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    178. Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. J Neurosci. 2005 Apr 20; 25(16):4099-107. Helton R, Cui J, Scheel JR, Ellison JA, Ames C, Gibson C, Blouw B, Ouyang L, Dragatsis I, Zeitlin S, Johnson RS, Lipton SA, Barlow C. PMID: 15843612; PMCID: PMC6724950.
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    179. The molecular basis of memantine action in Alzheimer's disease and other neurologic disorders: low-affinity, uncompetitive antagonism. Curr Alzheimer Res. 2005 Apr; 2(2):155-65. Lipton SA. PMID: 15974913.
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    180. Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders. J Alzheimers Dis. 2004 Dec; 6(6 Suppl):S61-74. Lipton SA. PMID: 15665416.
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    181. BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol Cell. 2004 Aug 13; 15(3):355-66. Chae HJ, Kim HR, Xu C, Bailly-Maitre B, Krajewska M, Krajewski S, Banares S, Cui J, Digicaylioglu M, Ke N, Kitada S, Monosov E, Thomas M, Kress CL, Babendure JR, Tsien RY, Lipton SA, Reed JC. PMID: 15304216.
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    182. Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10810-4. Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA. PMID: 15252205; PMCID: PMC490016.
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    183. Molecular pathways to neurodegeneration. Nat Med. 2004 Jul; 10 Suppl:S2-9. Bossy-Wetzel E, Schwarzenbacher R, Lipton SA. PMID: 15272266.
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    184. Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9855-60. Digicaylioglu M, Garden G, Timberlake S, Fletcher L, Lipton SA. PMID: 15210945; PMCID: PMC470763.
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    185. Erythropoietin for neurologic protection and diabetic neuropathy. N Engl J Med. 2004 Jun 10; 350(24):2516-7. Lipton SA. PMID: 15190146.
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    186. Erythropoietin protects cerebrocortical neurons from HIV-1/gp120-induced damage. Neuroreport. 2004 Apr 09; 15(5):761-3. Digicaylioglu M, Kaul M, Fletcher L, Dowen R, Lipton SA. PMID: 15073510.
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    187. Sporadic ALS: blame it on the editor. Nat Med. 2004 Apr; 10(4):347. Lipton SA. PMID: 15057227.
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    188. Turning down, but not off. Nature. 2004 Apr 01; 428(6982):473. Lipton SA. PMID: 15057811.
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    189. Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron. 2004 Feb 05; 41(3):351-65. Bossy-Wetzel E, Talantova MV, Lee WD, Schölzke MN, Harrop A, Mathews E, Götz T, Han J, Ellisman MH, Perkins GA, Lipton SA. PMID: 14766175.
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    190. Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond. J Neurovirol. 2004; 10 Suppl 1:97-101. Kaul M, Lipton SA. PMID: 14982746.
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    191. Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults. NeuroRx. 2004 Jan; 1(1):101-10. Lipton SA. PMID: 15717010; PMCID: PMC534915.
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    192. Translationally distinct populations of NMDA receptor subunit NR1 mRNA in the developing rat brain. J Neurochem. 2003 Dec; 87(5):1066-75. Awobuluyi M, Lipton SA, Sucher NJ. PMID: 14622087.
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    193. Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol. 2003 Dec; 15(6):706-16. Bossy-Wetzel E, Barsoum MJ, Godzik A, Schwarzenbacher R, Lipton SA. PMID: 14644195.
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    194. BAG1 over-expression in brain protects against stroke. Brain Pathol. 2003 Oct; 13(4):495-506. Kermer P, Digicaylioglu MH, Kaul M, Zapata JM, Krajewska M, Stenner-Liewen F, Takayama S, Krajewski S, Lipton SA, Reed JC. PMID: 14655755; PMCID: PMC8096046.
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    195. N-methyl-D-aspartate receptor subunit NR3A in the retina: developmental expression, cellular localization, and functional aspects. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4451-6. Sucher NJ, Kohler K, Tenneti L, Wong HK, Gründer T, Fauser S, Wheeler-Schilling T, Nakanishi N, Lipton SA, Guenther E. PMID: 14507892.
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    196. Glycine receptors and glycinergic synaptic input at the axon terminals of mammalian retinal rod bipolar cells. J Physiol. 2003 Dec 15; 553(Pt 3):895-909. Cui J, Ma YP, Lipton SA, Pan ZH. PMID: 14514876; PMCID: PMC2343622.
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    197. Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina. Mol Cell Biol. 2003 Jul; 23(13):4637-48. Fan X, Molotkov A, Manabe S, Donmoyer CM, Deltour L, Foglio MH, Cuenca AE, Blaner WS, Lipton SA, Duester G. PMID: 12808103; PMCID: PMC164835.
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    198. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J Biol Chem. 2003 Sep 05; 278(36):34641-53. Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS. PMID: 12819203.
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    199. Cell spreading controls endoplasmic and nuclear calcium: a physical gene regulation pathway from the cell surface to the nucleus. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5181-6. Itano N, Okamoto S, Zhang D, Lipton SA, Ruoslahti E. PMID: 12702768; PMCID: PMC154319.
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    200. Possible role for memantine in protecting retinal ganglion cells from glaucomatous damage. Surv Ophthalmol. 2003 Apr; 48 Suppl 1:S38-46. Lipton SA. PMID: 12852433.
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    201. Divergent NMDA signals leading to proapoptotic and antiapoptotic pathways in the rat retina. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):385-92. Manabe S, Lipton SA. PMID: 12506100.
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    202. Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Cell. 2002 Oct 18; 111(2):147-50. Lipton SA, Bossy-Wetzel E. PMID: 12408857.
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    203. Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain. J Comp Neurol. 2002 Sep 02; 450(4):303-17. Wong HK, Liu XB, Matos MF, Chan SF, Pérez-Otaño I, Boysen M, Cui J, Nakanishi N, Trimmer JS, Jones EG, Lipton SA, Sucher NJ. PMID: 12209845.
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    204. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J Neurosci. 2002 May 15; 22(10):4015-24. Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA. PMID: 12019321; PMCID: PMC6757636.
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    205. Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons. J Neurophysiol. 2002 Apr; 87(4):2052-63. Sasaki YF, Rothe T, Premkumar LS, Das S, Cui J, Talantova MV, Wong HK, Gong X, Chan SF, Zhang D, Nakanishi N, Sucher NJ, Lipton SA. PMID: 11929923.
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    206. Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3974-9. Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA. PMID: 11904443; PMCID: PMC122633.
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    207. Excitatory amino acid neurotoxicity. Adv Exp Med Biol. 2002; 513:3-40. Gillessen T, Budd SL, Lipton SA. PMID: 12575816.
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    208. 7-Chlorokynurenate Ameliorates Neuronal Injury Mediated by HIV Envelope Protein gp120 in Rodent Retinal Cultures. Eur J Neurosci. 1992; 4(12):1411-1415. Lipton SA. PMID: 12106405.
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