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Stuart Lipton

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentNeurosciences
Address9500 Gilman Drive #0973
La Jolla CA 92093
Phone858-657-8540
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    Collapse Research 
    Collapse Research Activities and Funding
    S-Nitrosylation-Induced Posttranslational Modification and Aberrant Cell Signaling in Sporadic Alzheimer's Disease
    NIH/NIA R01AG056259Sep 30, 2017 - May 31, 2022
    Role: Principal Investigator
    Dynamic Interactions of the S-Nitrosoproteome in Type 2 Diabetes/Metabolic Syndrome and Alzheimer?s Disease
    NIH/NIA RF1AG057409Sep 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Novel Proteomics Approach to HIV-Associated Neurocognitive Disorder & Drug Abuse
    NIH/NIDA DP1DA041722Apr 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Modeling Parkinson's Disease with Isogenic hiPSC-Derived Dopaminergic Neurons
    NIH/NINDS R01NS086890Apr 1, 2014 - Sep 30, 2019
    Role: Principal Investigator
    Transnasal Delivery of Chemokine Analogs in mouse NeuroAIDS Models
    NIH/NINDS R21NS083415Sep 30, 2013 - Aug 31, 2015
    Role: Principal Investigator
    Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    NIH/NINDS R21NS080799Sep 30, 2012 - Aug 31, 2014
    Role: Principal Investigator
    La Jolla Interdisciplinary Neuroscience Center Cores
    NIH/NINDS P30NS076411Sep 26, 2011 - Mar 31, 2017
    Role: Principal Investigator
    La Jolla-Parkinson's Disease Center Grant
    NIH/NIEHS P01ES016738Sep 15, 2008 - Jun 30, 2013
    Role: Principal Investigator
    La Jolla Interdisciplinary Neuroscience Center Cores
    NIH/NINDS P30NS057096Sep 22, 2006 - Aug 31, 2012
    Role: Principal Investigator
    Erythropoietin PLUS IGF-IN NEUROPROTECTION FROM AIDS
    NIH/NINDS R01NS047973Aug 15, 2004 - Aug 31, 2012
    Role: Principal Investigator
    S-Nitrosylation of Matrix Metalloproteinases in AIDS
    NIH/NINDS R01NS046994Jun 15, 2004 - Mar 31, 2009
    Role: Principal Investigator
    Caspase Cleavage of MEF2 Mediates Neuronal Apoptosis
    NIH/NINDS R01NS044326Aug 1, 2003 - Jul 31, 2009
    Role: Principal Investigator
    ERYTHROPOIETIN-INDUCED NEUROPROTECTION
    NIH/NINDS R01NS043242Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator
    Chemokines and Macrophages in HIV Neuronal Apoptosis
    NIH/NINDS R01NS041207Sep 28, 2001 - Jul 31, 2005
    Role: Principal Investigator
    Cellular/Molecular Pathophysiology of Intellectual and Developmental Disabilities
    NIH/NICHD P01HD029587Sep 1, 1992 - Feb 28, 2017
    Role: Principal Investigator
    AIDS-Related Neurotoxicity and Novel NMDAR Antagonists
    NIH/NEI R01EY009024Feb 1, 1991 - Apr 30, 2011
    Role: Principal Investigator
    THY-1 AND NEURITE REGENERATION BY RETINAL GANGLION CELLS
    NIH/NEI R01EY006087Sep 30, 1986 - Jun 30, 1996
    Role: Principal Investigator
    RETINAL GANGLION CELLS: ION CHANNELS &TRANSMITTERS
    NIH/NEI R01EY005477Aug 1, 1984 - Aug 31, 2012
    Role: Principal Investigator
    COMMUNICATION AND REGENERATION OF CNS NEURITES
    NIH/NINDS K07NS000879Jul 1, 1984 - Jun 30, 1990
    Role: Principal Investigator
    Neurobiology of Disease -- Teaching Workshop
    NIH/NINDS R13NS020032Aug 1, 1983 - Oct 31, 2006
    Role: Co-Principal Investigator
    DEVELOPMENTAL NEUROLOGY
    NIH/NINDS T32NS007264Jan 1, 1983 - Dec 31, 1998
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Howe JR, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ. The mouse as a model for neuropsychiatric drug development. Curr Biol. 2018 Sep 10; 28(17):R909-R914. PMID: 30205056.
      View in: PubMed
    2. Mann AP, Scodeller P, Hussain S, Braun GB, Mölder T, Toome K, Ambasudhan R, Teesalu T, Lipton SA, Ruoslahti E. Publisher Correction: Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease. Nat Commun. 2018 Mar 09; 9(1):1070. PMID: 29523838.
      View in: PubMed
    3. Ryan T, Bamm VV, Stykel MG, Coackley CL, Humphries KM, Jamieson-Williams R, Ambasudhan R, Mosser DD, Lipton SA, Harauz G, Ryan SD. Cardiolipin exposure on the outer mitochondrial membrane modulates a-synuclein. Nat Commun. 2018 02 26; 9(1):817. PMID: 29483518.
      View in: PubMed
    4. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Mar; 25(3):486-541. PMID: 29362479.
      View in: PubMed
    5. Satoh T, Lipton S. Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate. F1000Res. 2017; 6:2138. PMID: 29263788.
      View in: PubMed
    6. Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death Differ. 2018 Mar; 25(3):542-572. PMID: 29229998.
      View in: PubMed
    7. Oh CK, Sultan A, Platzer J, Dolatabadi N, Soldner F, McClatchy DB, Diedrich JK, Yates JR, Ambasudhan R, Nakamura T, Jaenisch R, Lipton SA. S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models. Cell Rep. 2017 Nov 21; 21(8):2171-2182. PMID: 29166608.
      View in: PubMed
    8. Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, Huang X, Sultan A, McKercher SR, Ambasudhan R, Xu H, Wang Y, Geschwind DH, Roberts AJ, Terskikh AV, Rissman RA, Masliah E, Lipton SA, Nakanishi N. NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism. Nat Commun. 2017 Nov 14; 8(1):1488. PMID: 29133852.
      View in: PubMed
    9. Mann AP, Scodeller P, Hussain S, Braun GB, Mölder T, Toome K, Ambasudhan R, Teesalu T, Lipton SA, Ruoslahti E. Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease. Nat Commun. 2017 Nov 10; 8(1):1403. PMID: 29123083.
      View in: PubMed
    10. Nakamura T, Lipton SA. 'SNO'-Storms Compromise Protein Activity and Mitochondrial Metabolism in Neurodegenerative Disorders. Trends Endocrinol Metab. 2017 12; 28(12):879-892. PMID: 29097102.
      View in: PubMed
    11. Nagar S, Trudler D, McKercher SR, Piña-Crespo J, Nakanishi N, Okamoto SI, Lipton SA. Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency. Invest Ophthalmol Vis Sci. 2017 07 01; 58(9):3741-3749. PMID: 28738418.
      View in: PubMed
    12. Nagar S, Noveral SM, Trudler D, Lopez KM, McKercher SR, Han X, Yates JR, Piña-Crespo JC, Nakanishi N, Satoh T, Okamoto SI, Lipton SA. MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress. Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E4048-E4056. PMID: 28461502.
      View in: PubMed
    13. Lipton SA, Rezaie T, Nutter A, Lopez KM, Parker J, Kosaka K, Satoh T, McKercher SR, Masliah E, Nakanishi N. Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models. Cell Death Dis. 2016 12 01; 7(12):e2499. PMID: 27906174.
      View in: PubMed
    14. Sunico CR, Sultan A, Nakamura T, Dolatabadi N, Parker J, Shan B, Han X, Yates JR, Masliah E, Ambasudhan R, Nakanishi N, Lipton SA. Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):E7564-E7571. PMID: 27821734.
      View in: PubMed
    15. Singec I, Crain AM, Hou J, Tobe BTD, Talantova M, Winquist AA, Doctor KS, Choy J, Huang X, La Monaca E, Horn DM, Wolf DA, Lipton SA, Gutierrez GJ, Brill LM, Snyder EY. Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling. Stem Cell Reports. 2016 09 13; 7(3):527-542. PMID: 27569059.
      View in: PubMed
    16. Macrez R, Stys PK, Vivien D, Lipton SA, Docagne F. Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities. Lancet Neurol. 2016 Sep; 15(10):1089-102. PMID: 27571160.
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    17. Eichmann C, Tzitzilonis C, Nakamura T, Kwiatkowski W, Maslennikov I, Choe S, Lipton SA, Riek R. S-Nitrosylation Induces Structural and Dynamical Changes in a Rhodanese Family Protein. J Mol Biol. 2016 09 25; 428(19):3737-51. PMID: 27473602.
      View in: PubMed
    18. Sanz-Blasco S, Piña-Crespo JC, Zhang X, McKercher SR, Lipton SA. Levetiracetam inhibits oligomeric Aß-induced glutamate release from human astrocytes. Neuroreport. 2016 06 15; 27(9):705-9. PMID: 27183239; PMCID: PMC4874889 [Available on 06/15/17].
    19. Lipton SA, Nordstedt C. Partnering with Big Pharma-What Academics Need to Know. Cell. 2016 Apr 21; 165(3):512-5. PMID: 27104971.
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    20. Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016 Feb 15; 6:20831. PMID: 26877209; PMCID: PMC4753484.
    21. Takahashi H, Xia P, Cui J, Talantova M, Bodhinathan K, Li W, Saleem S, Holland EA, Tong G, Piña-Crespo J, Zhang D, Nakanishi N, Larrick JW, McKercher SR, Nakamura T, Wang Y, Lipton SA. Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease. Sci Rep. 2016 Feb 12; 6:20750. PMID: 26867695; PMCID: PMC4751459.
    22. Akhtar MW, Sanz-Blasco S, Dolatabadi N, Parker J, Chon K, Lee MS, Soussou W, McKercher SR, Ambasudhan R, Nakamura T, Lipton SA. Elevated glucose and oligomeric ß-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nat Commun. 2016 Jan 08; 7:10242. PMID: 26743041; PMCID: PMC4729876.
    23. Nakamura T, Lipton SA. Protein S-Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases. Trends Pharmacol Sci. 2016 Jan; 37(1):73-84. PMID: 26707925.
      View in: PubMed
    24. Chen S, Cui J, Jiang T, Olson ES, Cai QY, Yang M, Wu W, Guthrie JM, Robertson JD, Lipton SA, Ma L, Tsien RY, Gu Z. Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke. J Cereb Blood Flow Metab. 2017 Jan; 37(1):188-200. PMID: 26681768.
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    25. Takahashi H, Xia P, Cui J, Talantova M, Bodhinathan K, Li W, Saleem S, Holland EA, Tong G, Piña-Crespo J, Zhang D, Nakanishi N, Larrick JW, McKercher SR, Nakamura T, Wang Y, Lipton SA. Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease. Sci Rep. 2015 Oct 19; 5:14781. PMID: 26477507; PMCID: PMC4609936.
    26. Nakato R, Ohkubo Y, Konishi A, Shibata M, Kaneko Y, Iwawaki T, Nakamura T, Lipton SA, Uehara T. Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress. Sci Rep. 2015 Oct 08; 5:14812. PMID: 26446798; PMCID: PMC4597200.
    27. Nakanishi N, Kang YJ, Tu S, McKercher SR, Masliah E, Lipton SA. Differential Effects of Pharmacologic and Genetic Modulation of NMDA Receptor Activity on HIV/gp120-Induced Neuronal Damage in an In Vivo Mouse Model. J Mol Neurosci. 2016 Jan; 58(1):59-65. PMID: 26374431; PMCID: PMC4821006.
    28. Satoh T, Stalder R, McKercher SR, Williamson RE, Roth GP, Lipton SA. Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules is Regulated by Electrochemical Oxidation Potential. ASN Neuro. 2015 Jul-Aug; 7(4). PMID: 26243592; PMCID: PMC4550314.
    29. Kim KS, Song YS, Jin J, Joe JH, So BI, Park JY, Fang CH, Kim MJ, Cho YH, Hwang S, Ro YS, Kim H, Ahn YH, Sung HJ, Sung JJ, Park SH, Lipton SA. Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat. Mol Cell Endocrinol. 2015 Oct 15; 414:64-72. PMID: 26190836.
      View in: PubMed
    30. Nakamura T, Lipton SA. Nitrosative Stress in the Nervous System: Guidelines for Designing Experimental Strategies to Study Protein S-Nitrosylation. Neurochem Res. 2016 Mar; 41(3):510-4. PMID: 26118537; PMCID: PMC4695327.
    31. Yang B, Qu M, Wang R, Chatterton JE, Liu XB, Zhu B, Narisawa S, Millan JL, Nakanishi N, Swoboda K, Lipton SA, Zhang D. The critical role of membralin in postnatal motor neuron survival and disease. Elife. 2015 May 15; 4. PMID: 25977983; PMCID: PMC4460860.
    32. Nakamura T, Prikhodko OA, Pirie E, Nagar S, Akhtar MW, Oh CK, McKercher SR, Ambasudhan R, Okamoto S, Lipton SA. Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases. Neurobiol Dis. 2015 Dec; 84:99-108. PMID: 25796565; PMCID: PMC4575233 [Available on 12/01/16].
    33. Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T, Ambasudhan R, McKercher SR, Masliah E, Lipton SA. Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid. J Neurochem. 2015 Jun; 133(6):898-908. PMID: 25692407; PMCID: PMC4465065.
    34. Chan SF, Huang X, McKercher SR, Zaidi R, Okamoto SI, Nakanishi N, Lipton SA. Transcriptional profiling of MEF2-regulated genes in human neural progenitor cells derived from embryonic stem cells. Genom Data. 2015 Mar 01; 3:24-27. PMID: 25485232.
      View in: PubMed
    35. Shimizu H, Koyama T, Yamada S, Lipton SA, Satoh T. Zonarol, a sesquiterpene from the brown algae Dictyopteris undulata, provides neuroprotection by activating the Nrf2/ARE pathway. Biochem Biophys Res Commun. 2015 Feb 20; 457(4):718-22. PMID: 25623531; PMCID: PMC4577281.
    36. Okamoto S, Lipton SA. S-Nitrosylation in neurogenesis and neuronal development. Biochim Biophys Acta. 2015 Aug; 1850(8):1588-93. PMID: 25527866; PMCID: PMC4441575.
    37. Tu S, Okamoto S, Lipton SA, Xu H. Oligomeric Aß-induced synaptic dysfunction in Alzheimer's disease. Mol Neurodegener. 2014 Nov 14; 9:48. PMID: 25394486; PMCID: PMC4237769.
    38. Choi MS, Nakamura T, Cho SJ, Han X, Holland EA, Qu J, Petsko GA, Yates JR, Liddington RC, Lipton SA. Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models. J Neurosci. 2014 Nov 05; 34(45):15123-31. PMID: 25378175; PMCID: PMC4220036.
    39. Lipton SA, Stevens CF. Stephen F. Heinemann: 1939-2014. Cell. 2014 Oct 09; 159(2):231-2. PMID: 25436266.
      View in: PubMed
    40. Okamoto S, Nakamura T, Cieplak P, Chan SF, Kalashnikova E, Liao L, Saleem S, Han X, Clemente A, Nutter A, Sances S, Brechtel C, Haus D, Haun F, Sanz-Blasco S, Huang X, Li H, Zaremba JD, Cui J, Gu Z, Nikzad R, Harrop A, McKercher SR, Godzik A, Yates JR, Lipton SA. S-nitrosylation-mediated redox transcriptional switch modulates neurogenesis and neuronal cell death. Cell Rep. 2014 Jul 10; 8(1):217-28. PMID: 25001280; PMCID: PMC4114155.
    41. Ambasudhan R, Dolatabadi N, Nutter A, Masliah E, Mckercher SR, Lipton SA. Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells. J Comp Neurol. 2014 Aug 15; 522(12):2845-56. PMID: 24756727; PMCID: PMC4388243.
    42. Molokanova E, Akhtar MW, Sanz-Blasco S, Tu S, Piña-Crespo JC, McKercher SR, Lipton SA. Differential effects of synaptic and extrasynaptic NMDA receptors on Aß-induced nitric oxide production in cerebrocortical neurons. J Neurosci. 2014 Apr 02; 34(14):5023-8. PMID: 24695719; PMCID: PMC3972726.
    43. Chan SF, Sances S, Brill LM, Okamoto S, Zaidi R, McKercher SR, Akhtar MW, Nakanishi N, Lipton SA. ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage. J Neurosci. 2014 Mar 26; 34(13):4640-53. PMID: 24672010; PMCID: PMC3965787.
    44. Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, McKercher SR, Cho YS, Lipton SA, Kim J, Ding S. Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Res. 2014 Jan; 24(1):126-9. PMID: 24296783; PMCID: PMC3879704.
    45. Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, Zhang Y, Han X, Nakamura T, Masliah E, Yates JR, Nakanishi N, Andreyev AY, Okamoto S, Jaenisch R, Ambasudhan R, Lipton SA. Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1a transcription. Cell. 2013 Dec 05; 155(6):1351-64. PMID: 24290359; PMCID: PMC4028128.
    46. Satoh T, McKercher SR, Lipton SA. Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic Biol Med. 2014 Jan; 66:45-57. PMID: 24262357.
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    47. Jeon GS, Nakamura T, Lee JS, Choi WJ, Ahn SW, Lee KW, Sung JJ, Lipton SA. Potential effect of S-nitrosylated protein disulfide isomerase on mutant SOD1 aggregation and neuronal cell death in amyotrophic lateral sclerosis. Mol Neurobiol. 2014 Apr; 49(2):796-807. PMID: 24091828.
      View in: PubMed
    48. Nakanishi N, Ryan SD, Zhang X, Khan A, Holland T, Cho EG, Huang X, Liao FF, Xu H, Lipton SA, Tu S. Synaptic protein a1-takusan mitigates amyloid-ß-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. J Neurosci. 2013 Aug 28; 33(35):14170-83. PMID: 23986251; PMCID: PMC3756761.
    49. Sunico CR, Nakamura T, Rockenstein E, Mante M, Adame A, Chan SF, Newmeyer TF, Masliah E, Nakanishi N, Lipton SA. S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease. Mol Neurodegener. 2013 Aug 28; 8:29. PMID: 23985028; PMCID: PMC3765907.
    50. Satoh T, McKercher SR, Lipton SA. Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. Free Radic Biol Med. 2013 Dec; 65:645-57. PMID: 23892355; PMCID: PMC3859717.
    51. Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, Alberch J, Wesseling JF, Pérez-Otaño I. Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Nat Med. 2013 Aug; 19(8):1030-8. PMID: 23852340; PMCID: PMC3936794.
    52. Haun F, Nakamura T, Shiu AD, Cho DH, Tsunemi T, Holland EA, La Spada AR, Lipton SA. S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease. Antioxid Redox Signal. 2013 Oct 10; 19(11):1173-84. PMID: 23641925; PMCID: PMC3785802.
    53. Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA. Aß induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):E2518-27. PMID: 23776240; PMCID: PMC3704025.
    54. Nakamura T, Tu S, Akhtar MW, Sunico CR, Okamoto S, Lipton SA. Aberrant protein s-nitrosylation in neurodegenerative diseases. Neuron. 2013 May 22; 78(4):596-614. PMID: 23719160; PMCID: PMC3712898.
    55. Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr; 19(4):473-80. PMID: 23524343; PMCID: PMC3911880.
    56. Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton SA. S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3137-42. PMID: 23382182; PMCID: PMC3581884.
    57. Haun F, Nakamura T, Lipton SA. Dysfunctional Mitochondrial Dynamics in the Pathophysiology of Neurodegenerative Diseases. J Cell Death. 2013; 6:27-35. PMID: 24587691.
      View in: PubMed
    58. Rezaie T, McKercher SR, Kosaka K, Seki M, Wheeler L, Viswanath V, Chun T, Joshi R, Valencia M, Sasaki S, Tozawa T, Satoh T, Lipton SA. Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2012 Nov 27; 53(12):7847-54. PMID: 23081978; PMCID: PMC3508754.
    59. Piña-Crespo JC, Talantova M, Cho EG, Soussou W, Dolatabadi N, Ryan SD, Ambasudhan R, McKercher S, Deisseroth K, Lipton SA. High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons. J Neurosci. 2012 Nov 07; 32(45):15837-42. PMID: 23136422; PMCID: PMC3513396.
    60. Akhtar MW, Sunico CR, Nakamura T, Lipton SA. Redox Regulation of Protein Function via Cysteine S-Nitrosylation and Its Relevance to Neurodegenerative Diseases. Int J Cell Biol. 2012; 2012:463756. PMID: 22956959; PMCID: PMC3431077.
    61. Qu J, Nakamura T, Holland EA, McKercher SR, Lipton SA. S-nitrosylation of Cdk5: potential implications in amyloid-ß-related neurotoxicity in Alzheimer disease. Prion. 2012 Sep-Oct; 6(4):364-70. PMID: 22874667; PMCID: PMC3609065.
    62. Henson MA, Larsen RS, Lawson SN, Pérez-Otaño I, Nakanishi N, Lipton SA, Philpot BD. Genetic deletion of NR3A accelerates glutamatergic synapse maturation. PLoS One. 2012; 7(8):e42327. PMID: 22870318; PMCID: PMC3411625.
    63. Nakamura T, Lipton SA. Emerging role of protein-protein transnitrosylation in cell signaling pathways. Antioxid Redox Signal. 2013 Jan 20; 18(3):239-49. PMID: 22657837; PMCID: PMC3518546.
    64. Nakamura T, Cho DH, Lipton SA. Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases. Exp Neurol. 2012 Nov; 238(1):12-21. PMID: 22771760; PMCID: PMC3645978.
    65. Banerjee S, Liao L, Russo R, Nakamura T, McKercher SR, Okamoto S, Haun F, Nikzad R, Zaidi R, Holland E, Eroshkin A, Yates JR, Lipton SA. Isobaric tagging-based quantification by mass spectrometry of differentially regulated proteins in synaptosomes of HIV/gp120 transgenic mice: implications for HIV-associated neurodegeneration. Exp Neurol. 2012 Aug; 236(2):298-306. PMID: 22575597; PMCID: PMC3392539.
    66. You H, Tsutsui S, Hameed S, Kannanayakal TJ, Chen L, Xia P, Engbers JD, Lipton SA, Stys PK, Zamponi GW. Aß neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1737-42. PMID: 22307640; PMCID: PMC3277185.
    67. Satoh T, Rezaie T, Seki M, Sunico CR, Tabuchi T, Kitagawa T, Yanagitai M, Senzaki M, Kosegawa C, Taira H, McKercher SR, Hoffman JK, Roth GP, Lipton SA. Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes. J Neurochem. 2011 Nov; 119(3):569-78. PMID: 21883218; PMCID: PMC4580255.
    68. Cho EG, Zaremba JD, McKercher SR, Talantova M, Tu S, Masliah E, Chan SF, Nakanishi N, Terskikh A, Lipton SA. MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model. PLoS One. 2011; 6(8):e24027. PMID: 21901155.
      View in: PubMed
    69. Qu J, Nakamura T, Cao G, Holland EA, McKercher SR, Lipton SA. S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14330-5. PMID: 21844361; PMCID: PMC3161554.
    70. Ambasudhan R, Talantova M, Coleman R, Yuan X, Zhu S, Lipton SA, Ding S. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell. 2011 Aug 05; 9(2):113-8. PMID: 21802386; PMCID: PMC4567246.
    71. Numajiri N, Takasawa K, Nishiya T, Tanaka H, Ohno K, Hayakawa W, Asada M, Matsuda H, Azumi K, Kamata H, Nakamura T, Hara H, Minami M, Lipton SA, Uehara T. On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN). Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10349-54. PMID: 21646525; PMCID: PMC3121815.
    72. Meng F, Yao D, Shi Y, Kabakoff J, Wu W, Reicher J, Ma Y, Moosmann B, Masliah E, Lipton SA, Gu Z. Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation. Mol Neurodegener. 2011 May 19; 6:34. PMID: 21595948; PMCID: PMC3120712.
    73. Li W, Sun W, Zhang Y, Wei W, Ambasudhan R, Xia P, Talantova M, Lin T, Kim J, Wang X, Kim WR, Lipton SA, Zhang K, Ding S. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8299-304. PMID: 21525408; PMCID: PMC3100988.
    74. Kim J, Efe JA, Zhu S, Talantova M, Yuan X, Wang S, Lipton SA, Zhang K, Ding S. Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7838-43. PMID: 21521790; PMCID: PMC3093517.
    75. Hardingham GE, Lipton SA. Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes. Antioxid Redox Signal. 2011 Apr 15; 14(8):1421-4. PMID: 20977364.
      View in: PubMed
    76. Larsen RS, Corlew RJ, Henson MA, Roberts AC, Mishina M, Watanabe M, Lipton SA, Nakanishi N, Pérez-Otaño I, Weinberg RJ, Philpot BD. NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity. Nat Neurosci. 2011 Mar; 14(3):338-44. PMID: 21297630; PMCID: PMC3474337.
    77. Nakamura T, Lipton SA. S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Antioxid Redox Signal. 2011 Apr 15; 14(8):1479-92. PMID: 20812868; PMCID: PMC3061195.
    78. Krajewska M, Xu L, Xu W, Krajewski S, Kress CL, Cui J, Yang L, Irie F, Yamaguchi Y, Lipton SA, Reed JC. Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury. Brain Res. 2011 Jan 25; 1370:227-37. PMID: 21075086; PMCID: PMC3019258.
    79. Kwak YD, Ma T, Diao S, Zhang X, Chen Y, Hsu J, Lipton SA, Masliah E, Xu H, Liao FF. NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Mol Neurodegener. 2010 Nov 10; 5:49. PMID: 21067594; PMCID: PMC2992530.
    80. Nakamura T, Lipton SA. Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases. Apoptosis. 2010 Nov; 15(11):1354-63. PMID: 20177970; PMCID: PMC2978885.
    81. Kang YJ, Digicaylioglu M, Russo R, Kaul M, Achim CL, Fletcher L, Masliah E, Lipton SA. Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders. Ann Neurol. 2010 Sep; 68(3):342-52. PMID: 20818790; PMCID: PMC3733362.
    82. Piña-Crespo JC, Talantova M, Micu I, States B, Chen HS, Tu S, Nakanishi N, Tong G, Zhang D, Heinemann SF, Zamponi GW, Stys PK, Lipton SA. Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits. J Neurosci. 2010 Aug 25; 30(34):11501-5. PMID: 20739572; PMCID: PMC2941801.
    83. Xia P, Chen HS, Zhang D, Lipton SA. Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses. J Neurosci. 2010 Aug 18; 30(33):11246-50. PMID: 20720132; PMCID: PMC2932667.
    84. Xia K, Xiong H, Shin Y, Wang D, Deerinck T, Takahashi H, Ellisman MH, Lipton SA, Tong G, Descalzi G, Zhang D, Zhuo M, Zhang Z. Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety. Mol Brain. 2010 Aug 02; 3:23. PMID: 20678225; PMCID: PMC2927585.
    85. Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR, Lipton SA. Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Mol Cell. 2010 Jul 30; 39(2):184-95. PMID: 20670888; PMCID: PMC2924818.
    86. Cho DH, Nakamura T, Lipton SA. Mitochondrial dynamics in cell death and neurodegeneration. Cell Mol Life Sci. 2010 Oct; 67(20):3435-47. PMID: 20577776.
      View in: PubMed
    87. Ghezzi P, Bernaudin M, Bernaudinb M, Bianchi R, Bianchic R, Blomgren K, Brines M, Campana W, Cavaletti G, Cerami A, Chopp M, Coleman T, Digicaylioglu M, Ehrenreich H, Erbayraktar S, Erbayraktar Z, Gassmann M, Genc S, Gokmen N, Grasso G, Juul S, Lipton SA, Hand CC, Latini R, Lauria G, Leist M, Newton SS, Petit E, Probert L, Sfacteria A, Siren AL, Talan M, Thiemermann C, Westenbrink D, Yaqoob M, Zhu C. Erythropoietin: not just about erythropoiesis. Lancet. 2010 Jun 19; 375(9732):2142. PMID: 20609950; PMCID: PMC4894326.
    88. Nakamura T, Cieplak P, Cho DH, Godzik A, Lipton SA. S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration. Mitochondrion. 2010 Aug; 10(5):573-8. PMID: 20447471; PMCID: PMC2918703.
    89. Gu Z, Nakamura T, Lipton SA. Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Mol Neurobiol. 2010 Jun; 41(2-3):55-72. PMID: 20333559; PMCID: PMC4586261.
    90. Nakamura T, Lipton SA. Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies. Cell Calcium. 2010 Feb; 47(2):190-7. PMID: 20060165; PMCID: PMC2875138.
    91. Zhao LC, Yang B, Wang R, Lipton SA, Zhang D. Type C botulinum toxin causes degeneration of motoneurons in vivo. Neuroreport. 2010 Jan 06; 21(1):14-18. PMID: 19907349; PMCID: PMC4351749.
    92. Zhao Y, Navia BA, Marra CM, Singer EJ, Chang L, Berger J, Ellis RJ, Kolson DL, Simpson D, Miller EN, Lipton SA, Evans SR, Schifitto G. Memantine for AIDS dementia complex: open-label report of ACTG 301. HIV Clin Trials. 2010 Jan-Feb; 11(1):59-67. PMID: 20400412; PMCID: PMC2981797.
    93. Okamoto S, Pouladi MA, Talantova M, Yao D, Xia P, Ehrnhoefer DE, Zaidi R, Clemente A, Kaul M, Graham RK, Zhang D, Vincent Chen HS, Tong G, Hayden MR, Lipton SA. Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat Med. 2009 Dec; 15(12):1407-13. PMID: 19915593; PMCID: PMC2789858.
    94. Seki M, Soussou W, Manabe S, Lipton SA. Protection of retinal ganglion cells by caspase substrate-binding peptide IQACRG from N-methyl-D-aspartate receptor-mediated excitotoxicity. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):1198-207. PMID: 19815732; PMCID: PMC2868456.
    95. Nakamura T, Lipton SA. According to GOSPEL: filling in the GAP(DH) of NO-mediated neurotoxicity. Neuron. 2009 Jul 16; 63(1):3-6. PMID: 19607786.
      View in: PubMed
    96. Fletcher L, Kohli S, Sprague SM, Scranton RA, Lipton SA, Parra A, Jimenez DF, Digicaylioglu M. Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory investigation. J Neurosurg. 2009 Jul; 111(1):164-70. PMID: 19284235.
      View in: PubMed
    97. Nakanishi N, Tu S, Shin Y, Cui J, Kurokawa T, Zhang D, Chen HS, Tong G, Lipton SA. Neuroprotection by the NR3A subunit of the NMDA receptor. J Neurosci. 2009 Apr 22; 29(16):5260-5. PMID: 19386922; PMCID: PMC2703294.
    98. Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA. S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science. 2009 Apr 03; 324(5923):102-5. PMID: 19342591; PMCID: PMC2823371.
    99. Nakamura T, Lipton SA. Cell death: protein misfolding and neurodegenerative diseases. Apoptosis. 2009 Apr; 14(4):455-68. PMID: 19130231.
      View in: PubMed
    100. Lipton SA, Li H, Zaremba JD, McKercher SR, Cui J, Kang YJ, Nie Z, Soussou W, Talantova M, Okamoto S, Nakanishi N. Autistic phenotype from MEF2C knockout cells. Science. 2009 Jan 09; 323(5911):208. PMID: 19131610.
      View in: PubMed
    101. Li H, Radford JC, Ragusa MJ, Shea KL, McKercher SR, Zaremba JD, Soussou W, Nie Z, Kang YJ, Nakanishi N, Okamoto S, Roberts AJ, Schwarz JJ, Lipton SA. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9397-402. PMID: 18599437; PMCID: PMC2453715.
    102. Li Z, McKercher SR, Cui J, Nie Z, Soussou W, Roberts AJ, Sallmen T, Lipton JH, Talantova M, Okamoto S, Lipton SA. Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. J Neurosci. 2008 Jun 25; 28(26):6557-68. PMID: 18579729; PMCID: PMC2679693.
    103. Lipton SA. NMDA receptor activity regulates transcription of antioxidant pathways. Nat Neurosci. 2008 Apr; 11(4):381-2. PMID: 18368041.
      View in: PubMed
    104. Seki M, Lipton SA. Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma. Prog Brain Res. 2008; 173:495-510. PMID: 18929130.
      View in: PubMed
    105. Nakamura T, Lipton SA. Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases. Antioxid Redox Signal. 2008 Jan; 10(1):87-101. PMID: 17961071.
      View in: PubMed
    106. Tong G, Takahashi H, Tu S, Shin Y, Talantova M, Zago W, Xia P, Nie Z, Goetz T, Zhang D, Lipton SA, Nakanishi N. Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons. J Neurophysiol. 2008 Jan; 99(1):122-32. PMID: 18003876; PMCID: PMC4586267.
    107. Fang J, Nakamura T, Cho DH, Gu Z, Lipton SA. S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18742-7. PMID: 18003920; PMCID: PMC2141847.
    108. Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, Kitajima C, Cui J, Kamins J, Okamoto S, Izumi M, Shirasawa T, Lipton SA. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem. 2008 Feb; 104(4):1116-31. PMID: 17995931; PMCID: PMC4566957.
    109. Stys PK, Lipton SA. White matter NMDA receptors: an unexpected new therapeutic target? Trends Pharmacol Sci. 2007 Nov; 28(11):561-6. PMID: 17961731.
      View in: PubMed
    110. Alirezaei M, Watry DD, Flynn CF, Kiosses WB, Masliah E, Williams BR, Kaul M, Lipton SA, Fox HS. Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. J Neurosci. 2007 Oct 10; 27(41):11047-55. PMID: 17928446.
      View in: PubMed
    111. Lipton SA. Pathologically activated therapeutics for neuroprotection. Nat Rev Neurosci. 2007 Oct; 8(10):803-8. PMID: 17882256.
      View in: PubMed
    112. Schifitto G, Navia BA, Yiannoutsos CT, Marra CM, Chang L, Ernst T, Jarvik JG, Miller EN, Singer EJ, Ellis RJ, Kolson DL, Simpson D, Nath A, Berger J, Shriver SL, Millar LL, Colquhoun D, Lenkinski R, Gonzalez RG, Lipton SA. Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study. AIDS. 2007 Sep 12; 21(14):1877-86. PMID: 17721095.
      View in: PubMed
    113. Nakagomi S, Barsoum MJ, Bossy-Wetzel E, Sütterlin C, Malhotra V, Lipton SA. A Golgi fragmentation pathway in neurodegeneration. Neurobiol Dis. 2008 Feb; 29(2):221-31. PMID: 17964175.
      View in: PubMed
    114. Okamoto S, Kang YJ, Brechtel CW, Siviglia E, Russo R, Clemente A, Harrop A, McKercher S, Kaul M, Lipton SA. HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest. Cell Stem Cell. 2007 Aug 16; 1(2):230-6. PMID: 18371353.
      View in: PubMed
    115. Tu S, Shin Y, Zago WM, States BA, Eroshkin A, Lipton SA, Tong GG, Nakanishi N. Takusan: a large gene family that regulates synaptic activity. Neuron. 2007 Jul 05; 55(1):69-85. PMID: 17610818; PMCID: PMC2902460.
    116. Redmond DE, Bjugstad KB, Teng YD, Ourednik V, Ourednik J, Wakeman DR, Parsons XH, Gonzalez R, Blanchard BC, Kim SU, Gu Z, Lipton SA, Markakis EA, Roth RH, Elsworth JD, Sladek JR, Sidman RL, Snyder EY. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12175-80. PMID: 17586681; PMCID: PMC1896134.
    117. Lipton SA. Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation. Curr Drug Targets. 2007 May; 8(5):621-32. PMID: 17504105.
      View in: PubMed
    118. Nakamura T, Gu Z, Lipton SA. Contribution of glutamatergic signaling to nitrosative stress-induced protein misfolding in normal brain aging and neurodegenerative diseases. Aging Cell. 2007 Jun; 6(3):351-9. PMID: 17388798.
      View in: PubMed
    119. Lee JP, Jeyakumar M, Gonzalez R, Takahashi H, Lee PJ, Baek RC, Clark D, Rose H, Fu G, Clarke J, McKercher S, Meerloo J, Muller FJ, Park KI, Butters TD, Dwek RA, Schwartz P, Tong G, Wenger D, Lipton SA, Seyfried TN, Platt FM, Snyder EY. Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat Med. 2007 Apr; 13(4):439-47. PMID: 17351625.
      View in: PubMed
    120. Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang YW. Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. J Biol Chem. 2007 Apr 13; 282(15):10873-80. PMID: 17303576.
      View in: PubMed
    121. Choi WT, Kaul M, Kumar S, Wang J, Kumar IM, Dong CZ, An J, Lipton SA, Huang Z. Neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (SMM) chemokines. J Biol Chem. 2007 Mar 09; 282(10):7154-63. PMID: 17218311.
      View in: PubMed
    122. Takahashi H, Shin Y, Cho SJ, Zago WM, Nakamura T, Gu Z, Ma Y, Furukawa H, Liddington R, Zhang D, Tong G, Chen HS, Lipton SA. Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif. Neuron. 2007 Jan 04; 53(1):53-64. PMID: 17196530; PMCID: PMC1855274.
    123. Lipton SA, Gu Z, Nakamura T. Inflammatory mediators leading to protein misfolding and uncompetitive/fast off-rate drug therapy for neurodegenerative disorders. Int Rev Neurobiol. 2007; 82:1-27. PMID: 17678953.
      View in: PubMed
    124. Wada A, Takahashi H, Lipton SA, Chen HS. NR3A modulates the outer vestibule of the "NMDA" receptor channel. J Neurosci. 2006 Dec 20; 26(51):13156-66. PMID: 17182766.
      View in: PubMed
    125. Satoh T, Lipton SA. Redox regulation of neuronal survival mediated by electrophilic compounds. Trends Neurosci. 2007 Jan; 30(1):37-45. PMID: 17137643.
      View in: PubMed
    126. Awobuluyi M, Yang J, Ye Y, Chatterton JE, Godzik A, Lipton SA, Zhang D. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors. Mol Pharmacol. 2007 Jan; 71(1):112-22. PMID: 17047094.
      View in: PubMed
    127. Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gräber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, Ellisman MH, Perkins GA, Bossy-Wetzel E. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J. 2006 Aug 23; 25(16):3900-11. PMID: 16874299; PMCID: PMC1553198.
    128. Kaul M, Lipton SA. Mechanisms of neuronal injury and death in HIV-1 associated dementia. Curr HIV Res. 2006 Jul; 4(3):307-18. PMID: 16842083.
      View in: PubMed
    129. Wang Y, Eu J, Washburn M, Gong T, Chen HS, James WL, Lipton SA, Stamler JS, Went GT, Porter S. The pharmacology of aminoadamantane nitrates. Curr Alzheimer Res. 2006 Jul; 3(3):201-4. PMID: 16842096.
      View in: PubMed
    130. Chen HS, Lipton SA. The chemical biology of clinically tolerated NMDA receptor antagonists. J Neurochem. 2006 Jun; 97(6):1611-26. PMID: 16805772.
      View in: PubMed
    131. Kaul M, Lipton SA. Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS. J Neuroimmune Pharmacol. 2006 Jun; 1(2):138-51. PMID: 18040780.
      View in: PubMed
    132. Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature. 2006 May 25; 441(7092):513-7. PMID: 16724068.
      View in: PubMed
    133. Sheng G, Chang GQ, Lin JY, Yu ZX, Fang ZH, Rong J, Lipton SA, Li SH, Tong G, Leibowitz SF, Li XJ. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nat Med. 2006 May; 12(5):526-33. PMID: 16604089.
      View in: PubMed
    134. Lipton SA. NMDA receptors, glial cells, and clinical medicine. Neuron. 2006 Apr 06; 50(1):9-11. PMID: 16600850.
      View in: PubMed
    135. Lipton SA. Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat Rev Drug Discov. 2006 Feb; 5(2):160-70. PMID: 16424917.
      View in: PubMed
    136. Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF. Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. J Neurosci. 2005 Dec 14; 25(50):11542-52. PMID: 16354912.
      View in: PubMed
    137. Manabe S, Gu Z, Lipton SA. Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4747-53. PMID: 16303975.
      View in: PubMed
    138. Ju WK, Misaka T, Kushnareva Y, Nakagomi S, Agarwal N, Kubo Y, Lipton SA, Bossy-Wetzel E. OPA1 expression in the normal rat retina and optic nerve. J Comp Neurol. 2005 Jul 18; 488(1):1-10. PMID: 15912498; PMCID: PMC1350956.
    139. Gu Z, Cui J, Brown S, Fridman R, Mobashery S, Strongin AY, Lipton SA. A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J Neurosci. 2005 Jul 06; 25(27):6401-8. PMID: 16000631.
      View in: PubMed
    140. Lipton SA, Nakamura T, Yao D, Shi ZQ, Uehara T, Gu Z. Comment on "S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function". Science. 2005 Jun 24; 308(5730):1870; author reply 1870. PMID: 15976289.
      View in: PubMed
    141. Lipton SA, Chen HS. Paradigm shift in NMDA receptor drug development. Expert Opin Ther Targets. 2005 Jun; 9(3):427-9. PMID: 15948664.
      View in: PubMed
    142. Chen HS, Lipton SA. Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels. J Pharmacol Exp Ther. 2005 Sep; 314(3):961-71. PMID: 15901795.
      View in: PubMed
    143. Brody SA, Nakanishi N, Tu S, Lipton SA, Geyer MA. A developmental influence of the N-methyl-D-aspartate receptor NR3A subunit on prepulse inhibition of startle. Biol Psychiatry. 2005 May 15; 57(10):1147-52. PMID: 15866554.
      View in: PubMed
    144. Helton R, Cui J, Scheel JR, Ellison JA, Ames C, Gibson C, Blouw B, Ouyang L, Dragatsis I, Zeitlin S, Johnson RS, Lipton SA, Barlow C. Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. J Neurosci. 2005 Apr 20; 25(16):4099-107. PMID: 15843612.
      View in: PubMed
    145. Lipton SA. The molecular basis of memantine action in Alzheimer's disease and other neurologic disorders: low-affinity, uncompetitive antagonism. Curr Alzheimer Res. 2005 Apr; 2(2):155-65. PMID: 15974913.
      View in: PubMed
    146. Lipton SA. Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders. J Alzheimers Dis. 2004 Dec; 6(6 Suppl):S61-74. PMID: 15665416.
      View in: PubMed
    147. Chae HJ, Kim HR, Xu C, Bailly-Maitre B, Krajewska M, Krajewski S, Banares S, Cui J, Digicaylioglu M, Ke N, Kitada S, Monosov E, Thomas M, Kress CL, Babendure JR, Tsien RY, Lipton SA, Reed JC. BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol Cell. 2004 Aug 13; 15(3):355-66. PMID: 15304216.
      View in: PubMed
    148. Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA. Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10810-4. PMID: 15252205; PMCID: PMC490016.
    149. Bossy-Wetzel E, Schwarzenbacher R, Lipton SA. Molecular pathways to neurodegeneration. Nat Med. 2004 Jul; 10 Suppl:S2-9. PMID: 15272266.
      View in: PubMed
    150. Digicaylioglu M, Garden G, Timberlake S, Fletcher L, Lipton SA. Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9855-60. PMID: 15210945; PMCID: PMC470763.
    151. Lipton SA. Erythropoietin for neurologic protection and diabetic neuropathy. N Engl J Med. 2004 Jun 10; 350(24):2516-7. PMID: 15190146.
      View in: PubMed
    152. Digicaylioglu M, Kaul M, Fletcher L, Dowen R, Lipton SA. Erythropoietin protects cerebrocortical neurons from HIV-1/gp120-induced damage. Neuroreport. 2004 Apr 09; 15(5):761-3. PMID: 15073510.
      View in: PubMed
    153. Lipton SA. Sporadic ALS: blame it on the editor. Nat Med. 2004 Apr; 10(4):347. PMID: 15057227.
      View in: PubMed
    154. Lipton SA. Turning down, but not off. Nature. 2004 Apr 01; 428(6982):473. PMID: 15057811.
      View in: PubMed
    155. Bossy-Wetzel E, Talantova MV, Lee WD, Schölzke MN, Harrop A, Mathews E, Götz T, Han J, Ellisman MH, Perkins GA, Lipton SA. Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron. 2004 Feb 05; 41(3):351-65. PMID: 14766175.
      View in: PubMed
    156. Kaul M, Lipton SA. Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond. J Neurovirol. 2004; 10 Suppl 1:97-101. PMID: 14982746.
      View in: PubMed
    157. Lipton SA. Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults. NeuroRx. 2004 Jan; 1(1):101-10. PMID: 15717010.
      View in: PubMed
    158. Bossy-Wetzel E, Barsoum MJ, Godzik A, Schwarzenbacher R, Lipton SA. Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol. 2003 Dec; 15(6):706-16. PMID: 14644195.
      View in: PubMed
    159. Awobuluyi M, Lipton SA, Sucher NJ. Translationally distinct populations of NMDA receptor subunit NR1 mRNA in the developing rat brain. J Neurochem. 2003 Dec; 87(5):1066-75. PMID: 14622087.
      View in: PubMed
    160. Sucher NJ, Kohler K, Tenneti L, Wong HK, Gründer T, Fauser S, Wheeler-Schilling T, Nakanishi N, Lipton SA, Guenther E. N-methyl-D-aspartate receptor subunit NR3A in the retina: developmental expression, cellular localization, and functional aspects. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4451-6. PMID: 14507892.
      View in: PubMed
    161. Kermer P, Digicaylioglu MH, Kaul M, Zapata JM, Krajewska M, Stenner-Liewen F, Takayama S, Krajewski S, Lipton SA, Reed JC. BAG1 over-expression in brain protects against stroke. Brain Pathol. 2003 Oct; 13(4):495-506. PMID: 14655755.
      View in: PubMed
    162. Cui J, Ma YP, Lipton SA, Pan ZH. Glycine receptors and glycinergic synaptic input at the axon terminals of mammalian retinal rod bipolar cells. J Physiol. 2003 Dec 15; 553(Pt 3):895-909. PMID: 14514876; PMCID: PMC2343622.
    163. Fan X, Molotkov A, Manabe S, Donmoyer CM, Deltour L, Foglio MH, Cuenca AE, Blaner WS, Lipton SA, Duester G. Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina. Mol Cell Biol. 2003 Jul; 23(13):4637-48. PMID: 12808103; PMCID: PMC164835.
    164. Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J Biol Chem. 2003 Sep 05; 278(36):34641-53. PMID: 12819203.
      View in: PubMed
    165. Itano N, Okamoto S, Zhang D, Lipton SA, Ruoslahti E. Cell spreading controls endoplasmic and nuclear calcium: a physical gene regulation pathway from the cell surface to the nucleus. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5181-6. PMID: 12702768; PMCID: PMC154319.
    166. Lipton SA. Possible role for memantine in protecting retinal ganglion cells from glaucomatous damage. Surv Ophthalmol. 2003 Apr; 48 Suppl 1:S38-46. PMID: 12852433.
      View in: PubMed
    167. Manabe S, Lipton SA. Divergent NMDA signals leading to proapoptotic and antiapoptotic pathways in the rat retina. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):385-92. PMID: 12506100.
      View in: PubMed
    168. Okamoto S, Sherman K, Bai G, Lipton SA. Effect of the ubiquitous transcription factors, SP1 and MAZ, on NMDA receptor subunit type 1 (NR1) expression during neuronal differentiation. Brain Res Mol Brain Res. 2002 Nov 15; 107(2):89-96. PMID: 12425938.
      View in: PubMed
    169. Lipton SA, Bossy-Wetzel E. Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Cell. 2002 Oct 18; 111(2):147-50. PMID: 12408857.
      View in: PubMed
    170. Wong HK, Liu XB, Matos MF, Chan SF, Pérez-Otaño I, Boysen M, Cui J, Nakanishi N, Trimmer JS, Jones EG, Lipton SA, Sucher NJ. Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain. J Comp Neurol. 2002 Sep 02; 450(4):303-17. PMID: 12209845.
      View in: PubMed
    171. Lipton SA, Choi YB, Takahashi H, Zhang D, Li W, Godzik A, Bankston LA. Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation. Trends Neurosci. 2002 Sep; 25(9):474-80. PMID: 12183209.
      View in: PubMed
    172. Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, Lipton SA. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science. 2002 Aug 16; 297(5584):1186-90. PMID: 12183632.
      View in: PubMed
    173. Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J Neurosci. 2002 May 15; 22(10):4015-24. PMID: 12019321.
      View in: PubMed
    174. Sasaki YF, Rothe T, Premkumar LS, Das S, Cui J, Talantova MV, Wong HK, Gong X, Chan SF, Zhang D, Nakanishi N, Sucher NJ, Lipton SA. Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons. J Neurophysiol. 2002 Apr; 87(4):2052-63. PMID: 11929923.
      View in: PubMed
    175. Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA. Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3974-9. PMID: 11904443; PMCID: PMC122633.
    176. Chatterton JE, Awobuluyi M, Premkumar LS, Takahashi H, Talantova M, Shin Y, Cui J, Tu S, Sevarino KA, Nakanishi N, Tong G, Lipton SA, Zhang D. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature. 2002 Feb 14; 415(6873):793-8. PMID: 11823786.
      View in: PubMed
    177. Gillessen T, Budd SL, Lipton SA. Excitatory amino acid neurotoxicity. Adv Exp Med Biol. 2002; 513:3-40. PMID: 12575816.
      View in: PubMed
    178. Lipton SA. 7-Chlorokynurenate Ameliorates Neuronal Injury Mediated by HIV Envelope Protein gp120 in Rodent Retinal Cultures. Eur J Neurosci. 1992; 4(12):1411-1415. PMID: 12106405.
      View in: PubMed
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