Armin Blesch

Title(s)Professor In Residence, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-1133-1174 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Wurzburg, Würzburg, GermanyPhD1995Genetics, Neurology

    Collapse Research 
    Collapse Research Activities and Funding
    Toll-like receptor 4 signaling in chronic neuropathic pain after SCI
    Craig H. Neilsen Foundation 543600Jan 1, 2020 - Dec 31, 2022
    Role: Principal Investigator
    Sensorimotor training and cortical mechanisms of pain after spinal cord injury
    NIH I01RX002840Nov 1, 2018 - Oct 31, 2022
    Role: Principal Investigator
    Regulatable Gene Transfer for Spinal Cord Injury
    NIH R01NS054883Apr 1, 2007 - Aug 31, 2011
    Role: Principal Investigator
    Regulatable Gene Therapy for Axonal Regeneration
    NIH R21NS046466Feb 15, 2004 - Jan 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alginate hydrogel cross-linked by Ca2+ to promote spinal cord neural stem/progenitor cell differentiation and functional recovery after a spinal cord injuryhh. Regen Biomater. 2022; 9:rbac057. Zhou J, Wu Y, Tang Z, Zou K, Chen J, Lei Z, Wan X, Liu Y, Zhang H, Wang Y, Blesch A, Lei T, Liu S. PMID: 36072264; PMCID: PMC9438746.
      View in: PubMed   Mentions: 6  
    2. Neural Stem Cells: Promoting Axonal Regeneration and Spinal Cord Connectivity. Cells. 2021 11 25; 10(12). de Freria CM, Van Niekerk E, Blesch A, Lu P. PMID: 34943804; PMCID: PMC8699545.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    3. Anisotropic Alginate Hydrogels Promote Axonal Growth across Chronic Spinal Cord Transections after Scar Removal. ACS Biomater Sci Eng. 2020 04 13; 6(4):2274-2286. Huang L, Wang Y, Zhu M, Wan X, Zhang H, Lei T, Blesch A, Liu S. PMID: 33455324.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    4. Peptides and Astroglia Improve the Regenerative Capacity of Alginate Gels in the Injured Spinal Cord. Tissue Eng Part A. 2019 04; 25(7-8):522-537. Schackel T, Kumar P, Günther M, Liu S, Brunner M, Sandner B, Puttagunta R, Müller R, Weidner N, Blesch A. PMID: 30351234.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    5. Sensorimotor Activity Partially Ameliorates Pain and Reduces Nociceptive Fiber Density in the Chronically Injured Spinal Cord. J Neurotrauma. 2018 09 15; 35(18):2222-2238. Sliwinski C, Nees TA, Puttagunta R, Weidner N, Blesch A. PMID: 29706124; PMCID: PMC6119231.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    6. Targeted tissue engineering: hydrogels with linear capillary channels for axonal regeneration after spinal cord injury. Neural Regen Res. 2018 Apr; 13(4):641-642. Liu S, Blesch A. PMID: 29722311; PMCID: PMC5950669.
      View in: PubMed   Mentions: 3  
    7. Systemic epothilone D improves hindlimb function after spinal cord contusion injury in rats. Exp Neurol. 2018 08; 306:250-259. Sandner B, Puttagunta R, Motsch M, Bradke F, Ruschel J, Blesch A, Weidner N. PMID: 29408734.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    8. Cortical electrical stimulation in female rats with a cervical spinal cord injury to promote axonal outgrowth. J Neurosci Res. 2018 05; 96(5):852-862. Jack AS, Hurd C, Forero J, Nataraj A, Fenrich K, Blesch A, Fouad K. PMID: 29239014.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    9. Depolarization and electrical stimulation enhance in vitro and in vivo sensory axon growth after spinal cord injury. Exp Neurol. 2018 02; 300:247-258. Goganau I, Sandner B, Weidner N, Fouad K, Blesch A. PMID: 29183676; PMCID: PMC5752127.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    10. Enhancing excitatory activity of somatosensory cortex alleviates neuropathic pain through regulating homeostatic plasticity. Sci Rep. 2017 10 06; 7(1):12743. Xiong W, Ping X, Ripsch MS, Chavez GSC, Hannon HE, Jiang K, Bao C, Jadhav V, Chen L, Chai Z, Ma C, Wu H, Feng J, Blesch A, White FA, Jin X. PMID: 28986567; PMCID: PMC5630599.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    11. Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury. Acta Biomater. 2017 09 15; 60:167-180. Liu S, Sandner B, Schackel T, Nicholson L, Chtarto A, Tenenbaum L, Puttagunta R, Müller R, Weidner N, Blesch A. PMID: 28735026.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    12. Neuropathic pain after spinal cord injury: the impact of sensorimotor activity. Pain. 2017 03; 158(3):371-376. Nees TA, Finnerup NB, Blesch A, Weidner N. PMID: 27941498.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    13. Human ESC-Derived Interneurons Improve Major Consequences of Spinal Cord Injury. Cell Stem Cell. 2016 10 06; 19(4):423-424. Blesch A. PMID: 27716521.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    14. Early-onset treadmill training reduces mechanical allodynia and modulates calcitonin gene-related peptide fiber density in lamina III/IV in a mouse model of spinal cord contusion injury. Pain. 2016 Mar; 157(3):687-697. Nees TA, Tappe-Theodor A, Sliwinski C, Motsch M, Rupp R, Kuner R, Weidner N, Blesch A. PMID: 26588690.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    15. A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. 2016 Mar 02; 89(5):956-70. Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. PMID: 26898779; PMCID: PMC4790095.
      View in: PubMed   Mentions: 174     Fields:    Translation:AnimalsCells
    16. Cell-seeded alginate hydrogel scaffolds promote directed linear axonal regeneration in the injured rat spinal cord. Acta Biomater. 2015 Nov; 27:140-150. Günther MI, Weidner N, Müller R, Blesch A. PMID: 26348141.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    17. AngleJ: A new tool for the automated measurement of neurite growth orientation in tissue sections. J Neurosci Methods. 2015 Aug 15; 251:143-50. Günther MI, Günther M, Schneiders M, Rupp R, Blesch A. PMID: 26051555.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    18. Large animal and primate models of spinal cord injury for the testing of novel therapies. Exp Neurol. 2015 Jul; 269:154-68. Kwon BK, Streijger F, Hill CE, Anderson AJ, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, Houle JD, Jakeman LB, Jeffery ND, Jones LA, Kleitman N, Kocsis J, Lu P, Magnuson DS, Marsala M, Moore SW, Mothe AJ, Oudega M, Plant GW, Rabchevsky AS, Schwab JM, Silver J, Steward O, Xu XM, Guest JD, Tetzlaff W. PMID: 25902036.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    19. Axonal amphoterin mRNA is regulated by translational control and enhances axon outgrowth. J Neurosci. 2015 Apr 08; 35(14):5693-706. Merianda TT, Coleman J, Kim HH, Kumar Sahoo P, Gomes C, Brito-Vargas P, Rauvala H, Blesch A, Yoo S, Twiss JL. PMID: 25855182; PMCID: PMC4388927.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    20. Limited Functional Effects of Subacute Syngeneic Bone Marrow Stromal Cell Transplantation After Rat Spinal Cord Contusion Injury. Cell Transplant. 2016; 25(1):125-39. Sandner B, Ciatipis M, Motsch M, Soljanik I, Weidner N, Blesch A. PMID: 25812176.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    21. Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science. 2015 Apr 17; 348(6232):347-52. Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F. PMID: 25765066; PMCID: PMC4445125.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    22. A radio-telemetric system to monitor cardiovascular function in rats with spinal cord transection and embryonic neural stem cell grafts. J Vis Exp. 2014 Oct 07; (92):e51914. Hou S, Blesch A, Lu P. PMID: 25350486; PMCID: PMC4841300.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. [Novel aspects of diagnostics and therapy of spinal cord diseases]. Nervenarzt. 2014 Aug; 85(8):946-54. Rupp R, Blesch A, Schad L, Draganski B, Weidner N. PMID: 25001239.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Neural stem cells in models of spinal cord injury. Exp Neurol. 2014 Nov; 261:494-500. Tuszynski MH, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. PMID: 25079369.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Thoracic rat spinal cord contusion injury induces remote spinal gliogenesis but not neurogenesis or gliogenesis in the brain. PLoS One. 2014; 9(7):e102896. Franz S, Ciatipis M, Pfeifer K, Kierdorf B, Sandner B, Bogdahn U, Blesch A, Winner B, Weidner N. PMID: 25050623; PMCID: PMC4106835.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    26. Neural stem cell dissemination after grafting to CNS injury sites. Cell. 2014 Jan 30; 156(3):388-9. Tuszynski MH, Wang Y, Graham L, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Lu P. PMID: 24485445.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    27. Long-term viral brain-derived neurotrophic factor delivery promotes spasticity in rats with a cervical spinal cord hemisection. Front Neurol. 2013; 4:187. Fouad K, Bennett DJ, Vavrek R, Blesch A. PMID: 24312075; PMCID: PMC3832889.
      View in: PubMed   Mentions: 32  
    28. Partial restoration of cardiovascular function by embryonic neural stem cell grafts after complete spinal cord transection. J Neurosci. 2013 Oct 23; 33(43):17138-49. Hou S, Tom VJ, Graham L, Lu P, Blesch A. PMID: 24155317; PMCID: PMC3807033.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    29. Demonstrating efficacy in preclinical studies of cellular therapies for spinal cord injury - how much is enough? Exp Neurol. 2013 Oct; 248:30-44. Kwon BK, Soril LJ, Bacon M, Beattie MS, Blesch A, Bresnahan JC, Bunge MB, Dunlop SA, Fehlings MG, Ferguson AR, Hill CE, Karimi-Abdolrezaee S, Lu P, McDonald JW, Müller HW, Oudega M, Rosenzweig ES, Reier PJ, Silver J, Sykova E, Xu XM, Guest JD, Tetzlaff W. PMID: 23727091.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    30. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Stem Cell Res. 2013 Sep; 11(2):758-71. Sandner B, Rivera FJ, Caioni M, Nicholson L, Eckstein V, Bogdahn U, Aigner L, Blesch A, Weidner N. PMID: 23770801.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    31. Characterization of supraspinal vasomotor pathways and autonomic dysreflexia after spinal cord injury in F344 rats. Auton Neurosci. 2013 Jun; 176(1-2):54-63. Hou S, Lu P, Blesch A. PMID: 23466042.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    32. Axonal transport of neural membrane protein 35 mRNA increases axon growth. J Cell Sci. 2013 Jan 01; 126(Pt 1):90-102. Merianda TT, Vuppalanchi D, Yoo S, Blesch A, Twiss JL. PMID: 23097042; PMCID: PMC3603513.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    33. Dependence of regenerated sensory axons on continuous neurotrophin-3 delivery. J Neurosci. 2012 Sep 19; 32(38):13206-20. Hou S, Nicholson L, van Niekerk E, Motsch M, Blesch A. PMID: 22993437; PMCID: PMC3513675.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    34. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012 Sep 14; 150(6):1264-73. Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Tuszynski MH. PMID: 22980985; PMCID: PMC3445432.
      View in: PubMed   Mentions: 390     Fields:    Translation:HumansAnimalsCells
    35. BDNF: the career of a multifaceted neurotrophin in spinal cord injury. Exp Neurol. 2012 Dec; 238(2):254-64. Weishaupt N, Blesch A, Fouad K. PMID: 22982152.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    36. Intrahippocampal transplantation of mesenchymal stromal cells promotes neuroplasticity. Cytotherapy. 2012 Oct; 14(9):1041-53. Coquery N, Blesch A, Stroh A, Fernández-Klett F, Klein J, Winter C, Priller J. PMID: 22762522.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    37. Motor axonal regeneration after partial and complete spinal cord transection. J Neurosci. 2012 Jun 13; 32(24):8208-18. Lu P, Blesch A, Graham L, Wang Y, Samara R, Banos K, Haringer V, Havton L, Weishaupt N, Bennett D, Fouad K, Tuszynski MH. PMID: 22699902; PMCID: PMC3407545.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    38. Neurotrophic factors in combinatorial approaches for spinal cord regeneration. Cell Tissue Res. 2012 Jul; 349(1):27-37. McCall J, Weidner N, Blesch A. PMID: 22526621; PMCID: PMC3376183.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    39. Neural stem cells for spinal cord repair. Cell Tissue Res. 2012 Jul; 349(1):349-62. Sandner B, Prang P, Rivera FJ, Aigner L, Blesch A, Weidner N. PMID: 22388657.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    40. Optimization of adult sensory neuron electroporation to study mechanisms of neurite growth. Front Mol Neurosci. 2012; 5:11. McCall J, Nicholson L, Weidner N, Blesch A. PMID: 22347167; PMCID: PMC3274834.
      View in: PubMed   Mentions: 7  
    41. Axonal transcription factors signal retrogradely in lesioned peripheral nerve. EMBO J. 2012 Mar 21; 31(6):1350-63. Ben-Yaakov K, Dagan SY, Segal-Ruder Y, Shalem O, Vuppalanchi D, Willis DE, Yudin D, Rishal I, Rother F, Bader M, Blesch A, Pilpel Y, Twiss JL, Fainzilber M. PMID: 22246183; PMCID: PMC3321171.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    42. Gene therapy, neurotrophic factors and spinal cord regeneration. Handb Clin Neurol. 2012; 109:563-74. Blesch A, Fischer I, Tuszynski MH. PMID: 23098737.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    43. Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: superiority to camp-mediated effects. Exp Neurol. 2012 May; 235(1):162-73. Blesch A, Lu P, Tsukada S, Alto LT, Roet K, Coppola G, Geschwind D, Tuszynski MH. PMID: 22227059; PMCID: PMC3334479.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    44. Gene therapy approaches to enhancing plasticity and regeneration after spinal cord injury. Exp Neurol. 2012 May; 235(1):62-9. Franz S, Weidner N, Blesch A. PMID: 21281633; PMCID: PMC3116048.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    45. TNF: a key neuroinflammatory mediator of neurotoxicity and neurodegeneration in models of Parkinson's disease. Adv Exp Med Biol. 2011; 691:539-40. McCoy MK, Ruhn KA, Blesch A, Tansey MG. PMID: 21153359.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    46. Effects of cavernous nerve reconstruction on expression of nitric oxide synthase isoforms in rats. BJU Int. 2010 Dec; 106(11):1726-31. Schlenker B, Matiasek K, Saur D, Gratzke C, Bauer RM, Herouy Y, Arndt C, Blesch A, Hartung R, Stief CG, Weidner N, May F. PMID: 20438559.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    47. Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease. Mol Ther. 2011 Jan; 19(1):46-52. Harms AS, Barnum CJ, Ruhn KA, Varghese S, Treviño I, Blesch A, Tansey MG. PMID: 20959812; PMCID: PMC3017447.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    48. Local and remote growth factor effects after primate spinal cord injury. J Neurosci. 2010 Jul 21; 30(29):9728-37. Brock JH, Rosenzweig ES, Blesch A, Moseanko R, Havton LA, Edgerton VR, Tuszynski MH. PMID: 20660255; PMCID: PMC2927098.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    49. Regeneration of long-tract axons through sites of spinal cord injury using templated agarose scaffolds. Biomaterials. 2010 Sep; 31(26):6719-29. Gros T, Sakamoto JS, Blesch A, Havton LA, Tuszynski MH. PMID: 20619785.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    50. Promoting directional axon growth from neural progenitors grafted into the injured spinal cord. J Neurosci Res. 2010 May 01; 88(6):1182-92. Bonner JF, Blesch A, Neuhuber B, Fischer I. PMID: 19908250; PMCID: PMC2844860.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    51. Conserved 3'-untranslated region sequences direct subcellular localization of chaperone protein mRNAs in neurons. J Biol Chem. 2010 Jun 04; 285(23):18025-38. Vuppalanchi D, Coleman J, Yoo S, Merianda TT, Yadhati AG, Hossain J, Blesch A, Willis DE, Twiss JL. PMID: 20308067; PMCID: PMC2878564.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    52. A dual promoter lentiviral vector for the in vivo evaluation of gene therapeutic approaches to axon regeneration after spinal cord injury. Gene Ther. 2010 May; 17(5):577-91. Löw K, Blesch A, Herrmann J, Tuszynski MH. PMID: 20200564.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    53. Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron. 2009 Oct 29; 64(2):165-72. Kadoya K, Tsukada S, Lu P, Coppola G, Geschwind D, Filbin MT, Blesch A, Tuszynski MH. PMID: 19874785; PMCID: PMC2773653.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    54. A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth. J Neurosci Res. 2009 Sep; 87(12):2624-31. Alfa RW, Tuszynski MH, Blesch A. PMID: 19405107; PMCID: PMC2854653.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    55. Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nat Neurosci. 2009 Sep; 12(9):1106-13. Alto LT, Havton LA, Conner JM, Hollis ER, Blesch A, Tuszynski MH. PMID: 19648914; PMCID: PMC2753201.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    56. Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7215-20. Hollis ER, Jamshidi P, Löw K, Blesch A, Tuszynski MH. PMID: 19359495; PMCID: PMC2678459.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    57. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis. 2009 Apr; 34(1):163-77. McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. PMID: 19320056; PMCID: PMC2948857.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    58. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009 Mar; 15(3):331-7. Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA, Tuszynski MH. PMID: 19198615; PMCID: PMC2838375.
      View in: PubMed   Mentions: 443     Fields:    Translation:Animals
    59. Spinal cord injury: plasticity, regeneration and the challenge of translational drug development. Trends Neurosci. 2009 Jan; 32(1):41-7. Blesch A, Tuszynski MH. PMID: 18977039.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimals
    60. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Exp Neurol. 2009 Jan; 215(1):153-9. Nagahara AH, Bernot T, Moseanko R, Brignolo L, Blesch A, Conner JM, Ramirez A, Gasmi M, Tuszynski MH. PMID: 19013154; PMCID: PMC2632603.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    61. IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury. Exp Neurol. 2009 Jan; 215(1):53-9. Hollis ER, Lu P, Blesch A, Tuszynski MH. PMID: 18938163; PMCID: PMC2632606.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    62. Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats. Mol Ther. 2008 Sep; 16(9):1572-9. McCoy MK, Ruhn KA, Martinez TN, McAlpine FE, Blesch A, Tansey MG. PMID: 18628756; PMCID: PMC2670754.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    63. GDNF-transduced Schwann cell grafts enhance regeneration of erectile nerves. Eur Urol. 2008 Nov; 54(5):1179-87. May F, Matiasek K, Vroemen M, Caspers C, Mrva T, Arndt C, Schlenker B, Gais P, Brill T, Buchner A, Blesch A, Hartung R, Stief C, Gansbacher B, Weidner N. PMID: 18313832.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    64. Progress and prospects: gene therapy clinical trials (part 2). Gene Ther. 2007 Nov; 14(22):1555-63. Alton E, Ferrari S, Griesenbach U, Aiuti A, Bachoud-Lévi AC, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA, Leen AM, Lemoine NR, McNeish IA, Meneguzzi G, Peschanski M, Roncarolo MG, Strayer DS, Tuszynski MH, Waxman DJ, Wilson JM. PMID: 17984995.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    65. Transient growth factor delivery sustains regenerated axons after spinal cord injury. J Neurosci. 2007 Sep 26; 27(39):10535-45. Blesch A, Tuszynski MH. PMID: 17898225; PMCID: PMC6673161.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    66. Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury. Spine (Phila Pa 1976). 2007 May 15; 32(11):1164-73. Kwon BK, Liu J, Lam C, Plunet W, Oschipok LW, Hauswirth W, Di Polo A, Blesch A, Tetzlaff W. PMID: 17495772.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    67. A neurovascular niche for neurogenesis after stroke. J Neurosci. 2006 Dec 13; 26(50):13007-16. Ohab JJ, Fleming S, Blesch A, Carmichael ST. PMID: 17167090; PMCID: PMC6674957.
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    68. Neurotrophic factors in neurodegeneration. Brain Pathol. 2006 Oct; 16(4):295-303. Blesch A. PMID: 17107599; PMCID: PMC8095767.
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    69. Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord. J Neurosci. 2006 Sep 20; 26(38):9713-21. Taylor L, Jones L, Tuszynski MH, Blesch A. PMID: 16988042; PMCID: PMC6674461.
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    70. Murine and HIV-based retroviral vectors for in vitro and in vivo gene transfer. Methods Mol Med. 2006; 129:241-54. Alfa RW, Blesch A. PMID: 17085815.
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    71. Nerve replacement strategies for cavernous nerves. Eur Urol. 2005 Sep; 48(3):372-8. May F, Vroemen M, Matiasek K, Henke J, Brill T, Lehmer A, Apprich M, Erhardt W, Schoeler S, Paul R, Blesch A, Hartung R, Gansbacher B, Weidner N. PMID: 15964126.
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    72. Loss of gene expression in lentivirus- and retrovirus-transduced neural progenitor cells is correlated to migration and differentiation in the adult spinal cord. Exp Neurol. 2005 Sep; 195(1):127-39. Vroemen M, Weidner N, Blesch A. PMID: 15921683.
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    73. Recommended guidelines for studies of human subjects with spinal cord injury. Spinal Cord. 2005 Aug; 43(8):453-8. Anderson DK, Beattie M, Blesch A, Bresnahan J, Bunge M, Dietrich D, Dietz V, Dobkin B, Fawcett J, Fehlings M, Fischer I, Grossman R, Guest J, Hagg T, Hall ED, Houle J, Kleitman N, McDonald J, Murray M, Privat A, Reier P, Steeves J, Steward O, Tetzlaff W, Tuszynski MH, Waxman SG, Whittemore S, Wolpaw J, Young W, Zheng B. PMID: 15824756.
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    74. Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons. Mol Ther. 2005 Jun; 11(6):916-25. Blesch A, Conner J, Pfeifer A, Gasmi M, Ramirez A, Britton W, Alfa R, Verma I, Tuszynski MH. PMID: 15922962.
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    75. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med. 2005 May; 11(5):551-5. Tuszynski MH, Thal L, Pay M, Salmon DP, U HS, Bakay R, Patel P, Blesch A, Vahlsing HL, Ho G, Tong G, Potkin SG, Fallon J, Hansen L, Mufson EJ, Kordower JH, Gall C, Conner J. PMID: 15852017.
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    76. Axonal responses to cellularly delivered NT-4/5 after spinal cord injury. Mol Cell Neurosci. 2004 Oct; 27(2):190-201. Blesch A, Yang H, Weidner N, Hoang A, Otero D. PMID: 15485774.
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    77. Adult neural progenitor cells provide a permissive guiding substrate for corticospinal axon growth following spinal cord injury. Eur J Neurosci. 2004 Oct; 20(7):1695-704. Pfeifer K, Vroemen M, Blesch A, Weidner N. PMID: 15379990.
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    78. [Tissue engineering of erectile nerves]. Urologe A. 2004 Oct; 43(10):1242-8. May F, Weidner N, Matiasek K, Vroemen M, Mrva T, Caspers C, Henke J, Brill T, Lehmer A, Blesch A, Erhardt W, Gänsbacher B, Hartung R. PMID: 15549162.
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    79. Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact? J Neurosci Res. 2004 Jul 15; 77(2):174-91. Lu P, Blesch A, Tuszynski MH. PMID: 15211585.
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    80. Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury. Yonsei Med J. 2004 Jun 30; 45 Suppl:28-31. Blesch A, Tuszynski MH. PMID: 15250047.
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    81. Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer. Methods. 2004 Jun; 33(2):164-72. Blesch A. PMID: 15121171.
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    82. Nucleus hears axon's pain. Nat Med. 2004 Mar; 10(3):236-7. Blesch A, Tuszynski MH. PMID: 14991043.
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    83. Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease. Prog Brain Res. 2004; 146:441-9. Tuszynski MH, Blesch A. PMID: 14699979.
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    84. Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. J Comp Neurol. 2003 Dec 15; 467(3):403-17. Blesch A, Tuszynski MH. PMID: 14608602.
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    85. NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection. Exp Neurol. 2003 May; 181(1):47-56. Tuszynski MH, Grill R, Jones LL, Brant A, Blesch A, Löw K, Lacroix S, Lu P. PMID: 12710933.
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    86. Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP) [corrected]. J Invest Dermatol. 2002 Sep; 119(3):562-9. Hau P, Wise P, Bosserhoff AK, Blesch A, Jachimczak P, Tschertner I, Bogdahn U, Apfel R. PMID: 12230496.
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    87. Nerve growth factor gene therapy for Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):207. Tuszynski MH, Thal L, U HS, Pay MM, Blesch A, Conner J, Vahlsing HL. PMID: 12212782.
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    88. Spontaneous and augmented growth of axons in the primate spinal cord: effects of local injury and nerve growth factor-secreting cell grafts. J Comp Neurol. 2002 Jul 15; 449(1):88-101. Tuszynski MH, Grill R, Jones LL, McKay HM, Blesch A. PMID: 12115695.
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    89. Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res Bull. 2002 Apr; 57(6):833-8. Blesch A, Lu P, Tuszynski MH. PMID: 12031281.
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    90. Melanoma-inhibiting activity (MIA/CD-RAP) is expressed in a variety of malignant tumors of mainly neuroectodermal origin. Anticancer Res. 2002 Mar-Apr; 22(2A):577-83. Hau P, Apfel R, Wiese P, Tschertner I, Blesch A, Bogdahn U. PMID: 12014625.
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    91. Therapeutic potential of nervous system growth factors for neurodegenerative disease. Expert Rev Neurother. 2002 Jan; 2(1):89-96. Merrill DA, Blesch A, Tuszynski MH. PMID: 19811018.
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    92. GDNF gene delivery to injured adult CNS motor neurons promotes axonal growth, expression of the trophic neuropeptide CGRP, and cellular protection. J Comp Neurol. 2001 Aug 06; 436(4):399-410. Blesch A, Tuszynski MH. PMID: 11447585.
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    93. Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons. J Comp Neurol. 2001 Aug 06; 436(4):456-70. Lu P, Blesch A, Tuszynski MH. PMID: 11447589.
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    94. Modulation of neuronal survival and axonal growth in vivo by tetracycline-regulated neurotrophin expression. Gene Ther. 2001 Jun; 8(12):954-60. Blesch A, Conner JM, Tuszynski MH. PMID: 11426336.
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    95. Delivery of neurotrophic factors to neuronal targets: toward gene therapy in the CNS. Drug News Perspect. 2000 Jun; 13(5):269-80. Blesch A. PMID: 12937641.
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    96. Neurite outgrowth can be modulated in vitro using a tetracycline-repressible gene therapy vector expressing human nerve growth factor. J Neurosci Res. 2000 Feb 01; 59(3):402-9. Blesch A, Uy HS, Diergardt N, Tuszynski MH. PMID: 10679776.
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    97. Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1. J Comp Neurol. 1999 Nov 01; 413(4):495-506. Weidner N, Blesch A, Grill RJ, Tuszynski MH. PMID: 10495438.
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    98. Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury. J Neurosci. 1999 May 01; 19(9):3556-66. Blesch A, Uy HS, Grill RJ, Cheng JG, Patterson PH, Tuszynski MH. PMID: 10212315; PMCID: PMC6782234.
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    99. Neurotrophin gene therapy in CNS models of trauma and degeneration. Prog Brain Res. 1998; 117:473-84. Blesch A, Grill RJ, Tuszynski MH. PMID: 9932426.
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    100. Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells. Exp Neurol. 1997 Dec; 148(2):444-52. Grill RJ, Blesch A, Tuszynski MH. PMID: 9417824.
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    101. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci. 1997 Jul 15; 17(14):5560-72. Grill R, Murai K, Blesch A, Gage FH, Tuszynski MH. PMID: 9204937; PMCID: PMC6793805.
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    102. Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cord. Cell Transplant. 1997 May-Jun; 6(3):361-8. Tuszynski MH, Murai K, Blesch A, Grill R, Miller I. PMID: 9171168.
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    103. Assignment of the human melanoma inhibitory activity gene (MIA) to 19q13.32-q13.33 by fluorescence in situ hybridization (FISH). Genomics. 1996 Jul 01; 35(1):265-7. Koehler MR, Bosserhoff A, von Beust G, Bauer A, Blesch A, Buettner R, Schlegel J, Bogdahn U, Schmid M. PMID: 8661134.
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    104. Transforming growth factor-beta-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides. Int J Cancer. 1996 Jan 26; 65(3):332-7. Jachimczak P, Hessdörfer B, Fabel-Schulte K, Wismeth C, Brysch W, Schlingensiepen KH, Bauer A, Blesch A, Bogdahn U. PMID: 8575854.
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    105. Transforming growth factor-beta-mediated regulation of human peripheral blood mononuclear cell proliferation as detected with phosphorothioate antisense oligodeoxynucleotides. Cell Immunol. 1995 Oct 01; 165(1):125-33. Jachimczak P, Fabel-Schulte K, Hessdörfer B, Brysch W, Schlingensiepen KH, Blesch A, Bogdahn U. PMID: 7671316.
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    106. Ex vivo gene therapy for Alzheimer's disease and spinal cord injury. Clin Neurosci. 1995-1996; 3(5):268-74. Blesch A, Tuszynski M. PMID: 8914793.
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    107. Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. Cancer Res. 1994 Nov 01; 54(21):5695-701. Blesch A, Bosserhoff AK, Apfel R, Behl C, Hessdoerfer B, Schmitt A, Jachimczak P, Lottspeich F, Buettner R, Bogdahn U. PMID: 7923218.
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