Theodore Friedmann

Title(s)Emeritus Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Lesch-Nyhan Disease: A Model for Complex Genetic, Proteomic & Metabolic Pathways
    NIH R24DK082840Sep 30, 2008 - Aug 31, 2014
    Role: Principal Investigator
    NIH R01NS044544Apr 1, 2003 - Mar 31, 2008
    Role: Principal Investigator
    NIH R21HD039250Jul 15, 2000 - May 31, 2003
    Role: Principal Investigator
    NIH R01HL064730May 1, 2000 - Apr 30, 2005
    Role: Principal Investigator
    NIH R01DK049023Aug 1, 1995 - Jul 31, 2000
    Role: Principal Investigator
    NIH R01HL053680Sep 30, 1994 - Aug 31, 2000
    Role: Principal Investigator
    NIH R01CA058317May 1, 1992 - Apr 30, 1995
    Role: Principal Investigator
    NIH R01HL047119Apr 1, 1991 - Mar 31, 1996
    Role: Principal Investigator
    NIH P01CA051495Feb 1, 1990 - Jan 31, 1995
    Role: Principal Investigator
    NIH R01HG000309Jul 1, 1989 - Jun 30, 1995
    Role: Principal Investigator
    NIH R01GM040790Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    NIH R01HD020034Apr 1, 1985 - Mar 31, 1996
    Role: Principal Investigator
    NIH R01GM028223Aug 1, 1980 - Jul 31, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Genetic therapies, human genetic enhancement, and � eugenics? Gene Ther. 2019 09; 26(9):351-353. Friedmann T. PMID: 31273325.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    2. Gene therapy for spinomuscular atrophy: a biomedical advance, a missed opportunity for more equitable drug pricing. Gene Ther. 2017 09; 24(9):503-505. Friedmann T. PMID: 28639617.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    3. ASGCT and JSGT Joint Position Statement on Human Genomic Editing. Mol Ther. 2015 Aug; 23(8):1282. Friedmann T, Jonlin EC, King NMP, Torbett BE, Wivel NA, Kaneda Y, Sadelain M. PMID: 26227250; PMCID: PMC4817859.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    4. The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation. PLoS One. 2013; 8(10):e74967. Kang TH, Park Y, Bader JS, Friedmann T. PMID: 24130677; PMCID: PMC3794013.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    5. Evolving concepts and techniques for anti-doping. Bioanalysis. 2012 Jul; 4(13):1667-80. Friedmann T, Flenker U, Georgakopoulos C, Alsayrafi M, Sottas PE, Williams SA, Gill RD. PMID: 22831482.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    6. Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3377-82. Mastrangelo L, Kim JE, Miyanohara A, Kang TH, Friedmann T. PMID: 22331909; PMCID: PMC3295269.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    7. MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch-Nyhan disease? Hum Mol Genet. 2012 Feb 01; 21(3):609-22. Guibinga GH, Hrustanovic G, Bouic K, Jinnah HA, Friedmann T. PMID: 22042773; PMCID: PMC3259014.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    8. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11; 58(16):1715-27. Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL. PMID: 21982317; PMCID: PMC3230644.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    9. HPRT deficiency coordinately dysregulates canonical Wnt and presenilin-1 signaling: a neuro-developmental regulatory role for a housekeeping gene? PLoS One. 2011 Jan 28; 6(1):e16572. Kang TH, Guibinga GH, Jinnah HA, Friedmann T. PMID: 21305049; PMCID: PMC3030599.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    10. How close are we to gene doping? Hastings Cent Rep. 2010 Mar-Apr; 40(2):20-2. Friedmann T. PMID: 20391845.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Ethics. Gene doping and sport. Science. 2010 Feb 05; 327(5966):647-8. Friedmann T, Rabin O, Frankel MS. PMID: 20133558.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    12. A fractionation method to identify qauntitative changes in protein expression mediated by IGF-1 on the proteome of murine C2C12 myoblasts. Proteome Sci. 2009 Aug 11; 7:28. King CC, Bouic K, Friedmann T. PMID: 19664293; PMCID: PMC2732595.
      View in: PubMed   Mentions: 2  
    13. Deficiency of the housekeeping gene hypoxanthine-guanine phosphoribosyltransferase (HPRT) dysregulates neurogenesis. Mol Ther. 2010 Jan; 18(1):54-62. Guibinga GH, Hsu S, Friedmann T. PMID: 19672249; PMCID: PMC2839227.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    14. Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts. BMC Genomics. 2008 Nov 11; 9:535. Bhasker CR, Friedmann T. PMID: 19014463; PMCID: PMC2628395.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. Characterization of the gene delivery properties of baculoviral-based virosomal vectors. J Virol Methods. 2008 Mar; 148(1-2):277-82. Guibinga GH, Song S, Loring J, Friedmann T. PMID: 18207578.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Partial characterization of the proteome of the mouse striatum. Proteomics. 2007 Nov; 7(21):3867-9. Guo LT, Friedmann T, King CC. PMID: 17922512.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    17. A decade of accomplishments: gene therapy and the ASGT. Mol Ther. 2007 Sep; 15(9):1576-8. Friedmann T. PMID: 17710079.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Tissue-specific aberrations of gene expression in HPRT-deficient mice: functional complexity in a monogenic disease? Mol Ther. 2007 Aug; 15(8):1432-43. Song S, Friedmann T. PMID: 17505472.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. Baculovirus GP64-pseudotyped HIV-based lentivirus vectors are stabilized against complement inactivation by codisplay of decay accelerating factor (DAF) or of a GP64-DAF fusion protein. Mol Ther. 2005 Apr; 11(4):645-51. Guibinga GH, Friedmann T. PMID: 15771967.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    20. Lessons for the stem cell discourse from the gene therapy experience. Perspect Biol Med. 2005; 48(4):585-91. Friedmann T. PMID: 16227669.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. Clinical gene therapy: lessons from the ether dome. Mol Ther. 2004 Aug; 10(2):205-6. Friedmann T. PMID: 15294165.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Discrepant effects of culture conditions on survival and function of dopaminergic neurons. Neuroreport. 2004 Apr 29; 15(6):1025-8. Smith DW, Friedmann T. PMID: 15076727.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Ligand-modified vesicular stomatitis virus glycoprotein displays a temperature-sensitive intracellular trafficking and virus assembly phenotype. Mol Ther. 2004 Jan; 9(1):76-84. Guibinga GH, Hall FL, Gordon EM, Ruoslahti E, Friedmann T. PMID: 14741780.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    24. Gene therapy's new era: a balance of unequivocal benefit and unequivocal harm. Mol Ther. 2003 Jul; 8(1):5-7. Friedmann T. PMID: 12872762.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Cell surface heparan sulfate is a receptor for attachment of envelope protein-free retrovirus-like particles and VSV-G pseudotyped MLV-derived retrovirus vectors to target cells. Mol Ther. 2002 May; 5(5 Pt 1):538-46. Guibinga GH, Miyanohara A, Esko JD, Friedmann T. PMID: 11991744.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    26. Stanfield Rogers: insights into virus vectors and failure of an early gene therapy model. Mol Ther. 2001 Oct; 4(4):285-8. Friedmann T. PMID: 11592829.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    27. VSV-G envelope glycoprotein forms complexes with plasmid DNA and MLV retrovirus-like particles in cell-free conditions and enhances DNA transfection. Mol Ther. 2001 Sep; 4(3):232-8. Okimoto T, Friedmann T, Miyanohara A. PMID: 11545614.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    28. The evolution of public review and oversight mechanisms in human gene transfer research: joint roles of the FDA and NIH. Curr Opin Biotechnol. 2001 Jun; 12(3):304-7. Friedmann T, Noguchi P, Mickelson C. PMID: 11404110.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Gene transfer and athletics- an impending problem. Mol Ther. 2001 Jun; 3(6):819-20. Friedmann T, Koss JO. PMID: 11407894.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    30. Separable mechanisms of attachment and cell uptake during retrovirus infection. J Virol. 2000 Nov; 74(22):10790-5. Sharma S, Miyanohara A, Friedmann T. PMID: 11044124; PMCID: PMC110954.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    31. Characterization of the dopamine defect in primary cultures of dopaminergic neurons from hypoxanthine phosphoribosyltransferase knockout mice. Mol Ther. 2000 May; 1(5 Pt 1):486-91. Smith DW, Friedmann T. PMID: 10933970.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    32. Medical ethics. Principles for human gene therapy studies. Science. 2000 Mar 24; 287(5461):2163-5. Friedmann T. PMID: 10744537.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    33. Changing roles for academia and industry in genetics and gene therapy. Mol Ther. 2000 Jan; 1(1):9-11. Friedmann T. PMID: 10933906.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Association of murine leukemia virus pol with virions, independent of Gag-Pol expression. J Virol. 1999 Nov; 73(11):9632-7. Buchschacher GL, Yu L, Murai F, Friedmann T, Miyanohara A. PMID: 10516075; PMCID: PMC113001.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    35. Bone marrow transplantation does not ameliorate the neurologic symptoms in mice deficient in hypoxanthine guanine phosphoribosyl transferase (HPRT). Metab Brain Dis. 1999 Mar; 14(1):57-65. Wojcik BE, Jinnah HA, Muller-Sieburg CE, Friedmann T. PMID: 10348314.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    36. In vitro cell-free conversion of noninfectious Moloney retrovirus particles to an infectious form by the addition of the vesicular stomatitis virus surrogate envelope G protein. J Virol. 1998 Aug; 72(8):6356-61. Abe A, Chen ST, Miyanohara A, Friedmann T. PMID: 9658075; PMCID: PMC109781.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    37. Enhanced gene transfer with fusogenic liposomes containing vesicular stomatitis virus G glycoprotein. J Virol. 1998 Jul; 72(7):6159-63. Abe A, Miyanohara A, Friedmann T. PMID: 9621082; PMCID: PMC110424.
      View in: PubMed   Mentions: 13     Fields:    
    38. Polybrene increases the efficiency of gene transfer by lipofection. Gene Ther. 1998 May; 5(5):708-11. Abe A, Miyanohara A, Friedmann T. PMID: 9797877.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    39. The road toward human gene therapy--a 25-year perspective. Ann Med. 1997 Dec; 29(6):575-7. Friedmann T. PMID: 9562527.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    40. Noninfectious virus-like particles produced by Moloney murine leukemia virus-based retrovirus packaging cells deficient in viral envelope become infectious in the presence of lipofection reagents. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10803-8. Sharma S, Murai F, Miyanohara A, Friedmann T. PMID: 9380714; PMCID: PMC23491.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    41. Overcoming the obstacles to gene therapy. Sci Am. 1997 Jun; 276(6):96-101. Friedmann T. PMID: 9163941.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    42. Adenovirus vector infection of chronic lymphocytic leukemia B cells. Blood. 1996 Dec 15; 88(12):4676-83. Cantwell MJ, Sharma S, Friedmann T, Kipps TJ. PMID: 8977261.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    43. The maturation of human gene therapy. Acta Paediatr. 1996 Nov; 85(11):1261-5. Friedmann T. PMID: 8955449.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    44. Efficient infection of a human T-cell line and of human primary peripheral blood leukocytes with a pseudotyped retrovirus vector. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11842-7. Sharma S, Cantwell M, Kipps TJ, Friedmann T. PMID: 8876225; PMCID: PMC38146.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    45. Generation of packaging cell lines for pseudotyped retroviral vectors of the G protein of vesicular stomatitis virus by using a modified tetracycline inducible system. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10057-62. Chen ST, Iida A, Guo L, Friedmann T, Yee JK. PMID: 8816750; PMCID: PMC38335.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    46. Simplified plasmid rescue of host sequences adjacent to integrated proviruses. Gene. 1996 Feb 12; 168(2):199-203. Kurdi-Haidar B, Friedmann T. PMID: 8654944.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    47. Human gene therapy--an immature genie, but certainly out of the bottle. Nat Med. 1996 Feb; 2(2):144-7. Friedmann T. PMID: 8574951.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    48. Differentiation of PC12 cells by infection with an HSV-1 vector expressing nerve growth factor. Gene Ther. 1995 Jul; 2(5):323-35. Wang MJ, Friedmann T, Johnson PA. PMID: 7671108.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    49. Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase. J Biol Chem. 1995 Mar 10; 270(10):5191-7. Benz DJ, Mol M, Ezaki M, Mori-Ito N, Zelán I, Miyanohara A, Friedmann T, Parthasarathy S, Steinberg D, Witztum JL. PMID: 7890629.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    50. Pseudotyped retroviral vectors for studies of human gene therapy. Nat Med. 1995 Mar; 1(3):275-7. Friedmann T, Yee JK. PMID: 7585046.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    51. Efficient in vivo transduction of the neonatal mouse liver with pseudotyped retroviral vectors. Gene Ther. 1995 Mar; 2(2):138-42. Miyanohara A, Yee JK, Bouic K, LaPorte P, Friedmann T. PMID: 7719930.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    52. Transduction of foreign regulatory sequences by a replication-defective herpes simplex virus type 1: the rat neuron-specific enolase promoter. Virus Res. 1995 Jan; 35(1):81-9. Roemer K, Johnson PA, Friedmann T. PMID: 7754677.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    53. Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. J Virol. 1994 Oct; 68(10):6347-62. Johnson PA, Wang MJ, Friedmann T. PMID: 8083974; PMCID: PMC237056.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    54. A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9564-8. Yee JK, Miyanohara A, LaPorte P, Bouic K, Burns JC, Friedmann T. PMID: 7937806; PMCID: PMC44853.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    55. Pantropic retroviral vector-mediated gene transfer, integration, and expression in cultured newt limb cells. Dev Biol. 1994 Sep; 165(1):285-9. Burns JC, Matsubara T, Lozinski G, Yee JK, Friedmann T, Washabaugh CH, Tsonis PA. PMID: 8088445.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    56. Gene therapy for neurological disorders. Trends Genet. 1994 Jun; 10(6):210-4. Friedmann T. PMID: 8073535.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    57. Mechanisms of action of the p53 tumor suppressor and prospects for cancer gene therapy by reconstitution of p53 function. Ann N Y Acad Sci. 1994 May 31; 716:265-80; discussion 280-2. Roemer K, Friedmann T. PMID: 8024199.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    58. Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles. Anticancer Res. 1994 May-Jun; 14(3A):1137-44. Runnebaum IB, Yee JK, Kieback DG, Sukumar S, Friedmann T. PMID: 8074464.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    59. Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. J Neurosci. 1994 Mar; 14(3 Pt 1):1164-75. Jinnah HA, Wojcik BE, Hunt M, Narang N, Lee KY, Goldstein M, Wamsley JK, Langlais PJ, Friedmann T. PMID: 7509865; PMCID: PMC6577527.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    60. High efficiency retroviral-mediated gene transduction into CD34+ cells purified from peripheral blood of breast cancer patients primed with chemotherapy and granulocyte-macrophage colony-stimulating factor. Hum Gene Ther. 1994 Feb; 5(2):203-8. Lu M, Maruyama M, Zhang N, Levine F, Friedmann T, Ho AD. PMID: 7514449.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    61. Gene therapy for disorders of the CNS. Gene Ther. 1994; 1 Suppl 1:S47-8. Friedmann T. PMID: 8542395.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    62. Replication-defective recombinant herpes simplex virus vectors. Methods Cell Biol. 1994; 43 Pt A:211-30. Johnson PA, Friedmann T. PMID: 7823863.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    63. Gene therapy. Am J Dis Child. 1993 Nov; 147(11):1167-74. Levine F, Friedmann T. PMID: 8237910.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    64. Modulation of cell proliferation and gene expression by a p53-estrogen receptor hybrid protein. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9252-6. Roemer K, Friedmann T. PMID: 8415687; PMCID: PMC47545.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    65. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc Natl Acad Sci U S A. 1993 Sep 01; 90(17):8033-7. Burns JC, Friedmann T, Driever W, Burrascano M, Yee JK. PMID: 8396259; PMCID: PMC47282.
      View in: PubMed   Mentions: 407     Fields:    Translation:HumansAnimalsCells
    66. Brain purines in a genetic mouse model of Lesch-Nyhan disease. J Neurochem. 1993 Jun; 60(6):2036-45. Jinnah HA, Page T, Friedmann T. PMID: 8492116.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    67. Gene therapy for disorders of the nervous system. Trends Biotechnol. 1993 May; 11(5):192-7. Friedmann T, Jinnah HA. PMID: 7763810.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    68. Gene therapy--a new kind of medicine. Trends Biotechnol. 1993 May; 11(5):156-9. Friedmann T. PMID: 7763803.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    69. Provirus-anchored long-range (PAL) mapping of mammalian genomes. Genomics. 1993 Feb; 15(2):305-10. Kurdi-Haidar B, Levine F, Roemer K, LaPorte P, Friedmann T. PMID: 8449495.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    70. Milestone and events in the early development of human gene therapy. Mol Genet Med. 1993; 3:1-32. Friedmann T. PMID: 8220161.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    71. Functional analysis of brain dopamine systems in a genetic mouse model of Lesch-Nyhan syndrome. J Pharmacol Exp Ther. 1992 Nov; 263(2):596-607. Jinnah HA, Langlais PJ, Friedmann T. PMID: 1432691.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    72. Approaches to gene therapy of complex multigenic diseases: cancer as a model and implications for cardiovascular disease and diabetes. Ann Med. 1992 Oct; 24(5):411-7. Friedmann T. PMID: 1418928.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    73. A brief history of gene therapy. Nat Genet. 1992 Oct; 2(2):93-8. Friedmann T. PMID: 1303270.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    74. Gene therapy of cancer through restoration of tumor-suppressor functions? Cancer. 1992 Sep 15; 70(6 Suppl):1810-7. Friedmann T. PMID: 1516033.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    75. Concepts and strategies for human gene therapy. Eur J Biochem. 1992 Sep 01; 208(2):211-25. Roemer K, Friedmann T. PMID: 1521521.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    76. Effects of choline and quiescence on Drosophila choline acetyltransferase expression and acetylcholine production by transduced rat fibroblasts. J Neurochem. 1992 Jun; 58(6):2019-29. Schinstine M, Rosenberg MB, Routledge-Ward C, Friedmann T, Gage FH. PMID: 1573390.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    77. Recombination between a herpes simplex virus type 1 vector deleted for immediate early gene 3 and the infected cell genome. J Gen Virol. 1992 Jun; 73 ( Pt 6):1553-8. Roemer K, Johnson PA, Friedmann T. PMID: 1318949.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    78. Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle. Somat Cell Mol Genet. 1992 May; 18(3):247-58. Roman M, Axelrod JH, Dai Y, Naviaux RK, Friedmann T, Verma IM. PMID: 1496420.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    79. Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1. J Virol. 1992 May; 66(5):2952-65. Johnson PA, Miyanohara A, Levine F, Cahill T, Friedmann T. PMID: 1373198; PMCID: PMC241054.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    80. Direct gene transfer to the liver with herpes simplex virus type 1 vectors: transient production of physiologically relevant levels of circulating factor IX. New Biol. 1992 Mar; 4(3):238-46. Miyanohara A, Johnson PA, Elam RL, Dai Y, Witztum JL, Verma IM, Friedmann T. PMID: 1316145.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    81. Long-term transgene expression from genetically modified hepatocytes grafted to the rat liver. New Biol. 1992 Mar; 4(3):261-7. Miyanohara A, Elam RL, Witztum JL, Friedmann T. PMID: 1581292.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    82. Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization. Mol Cell Neurosci. 1992 Feb; 3(1):64-78. Jinnah HA, Hess EJ, Wilson MC, Gage FH, Friedmann T. PMID: 19912847.
      View in: PubMed   Mentions: 11     Fields:    
    83. Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector. Brain Res Mol Brain Res. 1992 Jan; 12(1-3):95-102. Johnson PA, Yoshida K, Gage FH, Friedmann T. PMID: 1312210.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    84. Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene. Cancer Res. 1992 Jan 01; 52(1):222-6. Cheng J, Yee JK, Yeargin J, Friedmann T, Haas M. PMID: 1727382.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    85. Efficient gene expression in mammalian cells from a dicistronic transcriptional unit in an improved retroviral vector. Gene. 1991 Dec 15; 108(2):167-74. Levine F, Yee JK, Friedmann T. PMID: 1660834.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    86. Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome. Behav Neurosci. 1991 Dec; 105(6):1004-12. Jinnah HA, Gage FH, Friedmann T. PMID: 1777100.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    87. Activity of the simian virus 40 early promoter-enhancer in herpes simplex virus type 1 vectors is dependent on its position, the infected cell type, and the presence of Vmw175. J Virol. 1991 Dec; 65(12):6900-12. Roemer K, Johnson PA, Friedmann T. PMID: 1658381; PMCID: PMC250792.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    88. Gene therapy techniques. Curr Opin Biotechnol. 1991 Dec; 2(6):840-4. Levine F, Friedmann T. PMID: 1367958.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    89. Genetically modified tumor-infiltrating lymphocytes for cancer therapy. Cancer Cells. 1991 Jul; 3(7):271-4. Friedmann T. PMID: 1911040.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    90. Knock-in and knock-out. Transgenes, Development and Disease: A Keystone Symposium sponsored by Genentech and Immunex, Tamarron, CO, USA, January 12-18, 1991. New Biol. 1991 Apr; 3(4):331-5. Roemer K, Johnson PA, Friedmann T. PMID: 2065017.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    91. Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus. J Virol. 1991 Mar; 65(3):1202-7. Emi N, Friedmann T, Yee JK. PMID: 1847450; PMCID: PMC239887.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    92. Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype. J Virol. 1991 Feb; 65(2):700-10. Johnson PA, Best MG, Friedmann T, Parris DS. PMID: 1846193; PMCID: PMC239809.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    93. Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity. J Lipid Res. 1990 Dec; 31(12):2167-78. Sharkey MF, Miyanohara A, Elam RL, Friedmann T, Witztum JL. PMID: 2090710.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    94. Animal models of Lesch-Nyhan syndrome. Brain Res Bull. 1990 Sep; 25(3):467-75. Jinnah HA, Gage FH, Friedmann T. PMID: 2292045.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    95. Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK. Gene. 1990 Apr 16; 88(2):207-13. Johnson P, Friedmann T. PMID: 2347494.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    96. The human genome project--some implications of extensive "reverse genetic" medicine. Am J Hum Genet. 1990 Mar; 46(3):407-14. Friedmann T. PMID: 2309696; PMCID: PMC1683631.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    97. Grafting genetically modified cells to the brain: conceptual and technical issues. Prog Brain Res. 1990; 82:1-10. Gage FH, Fisher LJ, Jinnah HA, Rosenberg MB, Tuszynski MH, Friedmann T. PMID: 1981271.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    98. The evolving concept of gene therapy. Hum Gene Ther. 1990; 1(2):175-81. Friedmann T. PMID: 2078579.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    99. Gene therapy in the CNS: intracerebral grafting of genetically modified cells. Prog Brain Res. 1990; 86:205-17. Gage FH, Rosenberg MB, Tuszynski MH, Yoshida K, Armstrong DM, Hayes RC, Friedmann T. PMID: 2087558.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    100. Factors affecting long-term stability of Moloney murine leukemia virus-based vectors. Virology. 1989 Aug; 171(2):331-41. Xu L, Yee JK, Wolff JA, Friedmann T. PMID: 2503932.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    101. Progress toward human gene therapy. Science. 1989 Jun 16; 244(4910):1275-81. Friedmann T. PMID: 2660259.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimals
    102. Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene. Brain Res Mol Brain Res. 1989 Jun; 5(4):271-8. Shimohama S, Rosenberg MB, Fagan AM, Wolff JA, Short MP, Breakefield XO, Friedmann T, Gage FH. PMID: 2501628.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    103. Retrovirus vector-mediated gene transfer into hepatocytes. Mol Biol Med. 1989 Apr; 6(2):117-25. Friedmann T, Xu L, Wolff J, Yee JK, Miyanohara A. PMID: 2693887.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    104. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science. 1988 Dec 16; 242(4885):1563-6. Huang HJ, Yee JK, Shew JY, Chen PL, Bookstein R, Friedmann T, Lee EY, Lee WH. PMID: 3201247.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansCells
    105. Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitro. Proc Natl Acad Sci U S A. 1988 Sep; 85(17):6538-42. Miyanohara A, Sharkey MF, Witztum JL, Steinberg D, Friedmann T. PMID: 2842777; PMCID: PMC282008.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    106. Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2210-4. Bookstein R, Lee EY, To H, Young LJ, Sery TW, Hayes RC, Friedmann T, Lee WH. PMID: 2895471; PMCID: PMC279959.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    107. Applications and implications of genome related biotechnology. Basic Life Sci. 1988; 46:149-59. Friedmann T. PMID: 3223869.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    108. Grafting genetically modified cells to the brain: possibilities for the future. Neuroscience. 1987 Dec; 23(3):795-807. Gage FH, Wolff JA, Rosenberg MB, Xu L, Yee JK, Shults C, Friedmann T. PMID: 3325854.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    109. Adult mammalian hepatocyte as target cell for retroviral gene transfer: a model for gene therapy. Somat Cell Mol Genet. 1987 Jul; 13(4):423-8. Wolff JA, Yee JK, Skelly H, Moores J, Respess J, Friedmann T, Leffert H. PMID: 3484086.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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