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Theodore Friedmann

Title(s)Professor, Pediatrics
SchoolHealth Sciences
Phone858-534-4268
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    Collapse Research 
    Collapse Research Activities and Funding
    Lesch-Nyhan Disease: A Model for Complex Genetic, Proteomic &Metabolic Pathways
    NIH/NIDDK R24DK082840Sep 30, 2008 - Aug 31, 2014
    Role: Principal Investigator
    GENETIC ABBERATIONS IN HPRT DEFICIENCY
    NIH/NINDS R01NS044544Apr 1, 2003 - Mar 31, 2008
    Role: Principal Investigator
    ARRAY SCREENING FOR LESCH NYHAN DISEASE
    NIH/NICHD R21HD039250Jul 15, 2000 - May 31, 2003
    Role: Principal Investigator
    GENE TRANSFER TO THE VASCULAR ENDOTHELIUM
    NIH/NHLBI R01HL064730May 1, 2000 - Apr 30, 2005
    Role: Principal Investigator
    GENE THERAPY OF HYPERCHOLESTEROLEMIA
    NIH/NIDDK R01DK049023Aug 1, 1995 - Jul 31, 2000
    Role: Principal Investigator
    RETROVIRAL VECTOR BASED GENE THERAPY FOR HEMOPHILIA B
    NIH/NHLBI R01HL053680Sep 30, 1994 - Aug 31, 2000
    Role: Principal Investigator
    GENE TRANSFER FOR SUPPRESSION OF THE TUMOR PHENOTYPE
    NIH/NCI R01CA058317May 1, 1992 - Apr 30, 1995
    Role: Principal Investigator
    TRANSDUCTION OF AIRWAY EPITHELIA BY RETROVIRAL VECTORS
    NIH/NHLBI R01HL047119Apr 1, 1991 - Mar 31, 1996
    Role: Principal Investigator
    CANCER SUPPRESSION BY THE RETINOBLASTOMA GENE
    NIH/NCI P01CA051495Feb 1, 1990 - Jan 31, 1995
    Role: Principal Investigator
    PHYSICAL MAP OF THE HUMAN X CHROMOSOME
    NIH/NHGRI R01HG000309Jul 1, 1989 - Jun 30, 1995
    Role: Principal Investigator
    PHYSICAL MAP OF THE HUMAN X CHROMOSOME
    NIH/NIGMS R01GM040790Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    MODELS FOR CNS GENE THERAPY
    NIH/NICHD R01HD020034Apr 1, 1985 - Mar 31, 1996
    Role: Principal Investigator
    THE HUMAN HPRT GENE AND X CHROMOSOME ORGANIZATION
    NIH/NIGMS R01GM028223Aug 1, 1980 - Jul 31, 1987
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Friedmann T. Genetic therapies, human genetic enhancement, and … eugenics? Gene Ther. 2019 Jul 04. PMID: 31273325.
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    2. Adashi EY, Caplan AL, Capron A, Chapman AR, Cho M, Clayton EW, Cohen IG, Cook-Deegan R, Faden RR, Friedmann T, Gostin LO, Greely HT, Johnston J, Juengst E, King PA, Knowles LP, Lyerly AD, McGuire AL, Moreno JD, Rothenberg K, Truog RD, Walters L. In support of mitochondrial replacement therapy. Nat Med. 2019 06; 25(6):870-871. PMID: 31160819.
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    3. Friedmann T. Gene therapy for spinomuscular atrophy: a biomedical advance, a missed opportunity for more equitable drug pricing. Gene Ther. 2017 09; 24(9):503-505. PMID: 28639617.
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    4. Wang G, Karanikolou A, Verdouka I, Friedmann T, Pitsiladis Y. Next Generation "Omics" Approaches in the "Fight" against Blood Doping. Med Sport Sci. 2017; 62:119-128. PMID: 28571016.
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    5. Friedmann T. Happy Anniversary. Mol Ther. 2007 Jun; 15(6):1035-1036. PMID: 28182920.
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    6. Friedmann T. An ASGCT Perspective on the National Academies Genome Editing Summit. Mol Ther. 2016 Feb; 24(1):1-2. PMID: 26854182; PMCID: PMC4754555 [Available on 02/01/17].
    7. Friedmann T, Jonlin EC, King NMP, Torbett BE, Wivel NA, Kaneda Y, Sadelain M. ASGCT and JSGT Joint Position Statement on Human Genomic Editing. Mol Ther. 2015 Aug; 23(8):1282. PMID: 26227250; PMCID: PMC4817859.
    8. Kang TH, Friedmann T. Alzheimer's disease shares gene expression aberrations with purinergic dysregulation of HPRT deficiency (Lesch-Nyhan disease). Neurosci Lett. 2015 Mar 17; 590:35-9. PMID: 25636690.
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    9. Kang TH, Park Y, Bader JS, Friedmann T. The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation. PLoS One. 2013; 8(10):e74967. PMID: 24130677.
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    10. Friedmann T, Flenker U, Georgakopoulos C, Alsayrafi M, Sottas PE, Williams SA, Gill RD. Evolving concepts and techniques for anti-doping. Bioanalysis. 2012 Jul; 4(13):1667-80. PMID: 22831482.
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    11. Corrigan-Curay J, Cohen-Haguenauer O, O'Reilly M, Ross SR, Fan H, Rosenberg N, Somia N, King N, Friedmann T, Dunbar C, Aiuti A, Naldini L, Baum C, von Kalle C, Kiem HP, Montini E, Bushman F, Sorrentino BP, Carrondo M, Malech H, Gahrton G, Shapiro R, Wolff L, Rosenthal E, Jambou R, Zaia J, Kohn DB. Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy. Mol Ther. 2012 Jun; 20(6):1084-94. PMID: 22652996; PMCID: PMC3369284.
    12. Mastrangelo L, Kim JE, Miyanohara A, Kang TH, Friedmann T. Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3377-82. PMID: 22331909; PMCID: PMC3295269.
    13. Friedmann T. The successful clinical use of viral vectors for human gene therapy. Preface. Methods Enzymol. 2012; 507:xvii-xx. PMID: 22365783.
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    14. Guibinga GH, Hrustanovic G, Bouic K, Jinnah HA, Friedmann T. MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch-Nyhan disease? Hum Mol Genet. 2012 Feb 01; 21(3):609-22. PMID: 22042773; PMCID: PMC3259014.
    15. Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11; 58(16):1715-27. PMID: 21982317; PMCID: PMC3230644.
    16. Kang TH, Guibinga GH, Jinnah HA, Friedmann T. HPRT deficiency coordinately dysregulates canonical Wnt and presenilin-1 signaling: a neuro-developmental regulatory role for a housekeeping gene? PLoS One. 2011 Jan 28; 6(1):e16572. PMID: 21305049.
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    17. Guibinga GH, Friedmann T. Preparation of pseudotyped lentiviral vectors resistant to inactivation by serum complement. Cold Spring Harb Protoc. 2010 Jul 01; 2010(7):pdb.prot5420. PMID: 20647353.
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    18. Friedmann T. How close are we to gene doping? Hastings Cent Rep. 2010 Mar-Apr; 40(2):20-2. PMID: 20391845.
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    19. Friedmann T, Rabin O, Frankel MS. Ethics. Gene doping and sport. Science. 2010 Feb 05; 327(5966):647-8. PMID: 20133558.
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    20. King CC, Bouic K, Friedmann T. A fractionation method to identify qauntitative changes in protein expression mediated by IGF-1 on the proteome of murine C2C12 myoblasts. Proteome Sci. 2009 Aug 11; 7:28. PMID: 19664293; PMCID: PMC2732595.
    21. Guibinga GH, Hsu S, Friedmann T. Deficiency of the housekeeping gene hypoxanthine-guanine phosphoribosyltransferase (HPRT) dysregulates neurogenesis. Mol Ther. 2010 Jan; 18(1):54-62. PMID: 19672249; PMCID: PMC2839227.
    22. Nienhuis A, Friedmann T. An integrated funding mechanism for clinical trials in human gene therapy. Mol Ther. 2009 Jul; 17(7):1117-8. PMID: 19564863; PMCID: PMC2835213.
    23. Bhasker CR, Friedmann T. Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts. BMC Genomics. 2008 Nov 11; 9:535. PMID: 19014463; PMCID: PMC2628395.
    24. Friedmann T. The ASGT and ethical codes for clinical research. Mol Ther. 2008 Oct; 16(10):1643-4. PMID: 18813316.
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    25. Guibinga GH, Song S, Loring J, Friedmann T. Characterization of the gene delivery properties of baculoviral-based virosomal vectors. J Virol Methods. 2008 Mar; 148(1-2):277-82. PMID: 18207578.
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    26. Friedmann T. A new serious adverse event in a gene therapy study. Mol Ther. 2007 Nov; 15(11):1899-900. PMID: 17948042.
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    27. Guo LT, Friedmann T, King CC. Partial characterization of the proteome of the mouse striatum. Proteomics. 2007 Nov; 7(21):3867-9. PMID: 17922512.
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    28. Friedmann T. A decade of accomplishments: gene therapy and the ASGT. Mol Ther. 2007 Sep; 15(9):1576-8. PMID: 17710079.
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    29. Song S, Friedmann T. Tissue-specific aberrations of gene expression in HPRT-deficient mice: functional complexity in a monogenic disease? Mol Ther. 2007 Aug; 15(8):1432-43. PMID: 17505472.
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    30. Schneider AJ, Friedmann T. Gene doping in sports: the science and ethics of genetically modified athletes. Adv Genet. 2006; 51:1-110. PMID: 16504745.
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    31. Guibinga GH, Friedmann T. Baculovirus GP64-pseudotyped HIV-based lentivirus vectors are stabilized against complement inactivation by codisplay of decay accelerating factor (DAF) or of a GP64-DAF fusion protein. Mol Ther. 2005 Apr; 11(4):645-51. PMID: 15771967.
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    32. Friedmann T. Lessons for the stem cell discourse from the gene therapy experience. Perspect Biol Med. 2005; 48(4):585-91. PMID: 16227669.
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    33. Friedmann T. Clinical gene therapy: lessons from the ether dome. Mol Ther. 2004 Aug; 10(2):205-6. PMID: 15294165.
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    34. Smith DW, Friedmann T. Discrepant effects of culture conditions on survival and function of dopaminergic neurons. Neuroreport. 2004 Apr 29; 15(6):1025-8. PMID: 15076727.
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    35. Guibinga GH, Hall FL, Gordon EM, Ruoslahti E, Friedmann T. Ligand-modified vesicular stomatitis virus glycoprotein displays a temperature-sensitive intracellular trafficking and virus assembly phenotype. Mol Ther. 2004 Jan; 9(1):76-84. PMID: 14741780.
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    36. Friedmann T. Plus ça change... Mol Ther. 2003 Nov; 8(5):701. PMID: 14632022.
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    37. Friedmann T. Gene therapy's new era: a balance of unequivocal benefit and unequivocal harm. Mol Ther. 2003 Jul; 8(1):5-7. PMID: 12872762.
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    38. Guibinga GH, Miyanohara A, Esko JD, Friedmann T. Cell surface heparan sulfate is a receptor for attachment of envelope protein-free retrovirus-like particles and VSV-G pseudotyped MLV-derived retrovirus vectors to target cells. Mol Ther. 2002 May; 5(5 Pt 1):538-46. PMID: 11991744.
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    39. Visser JE, Smith DW, Moy SS, Breese GR, Friedmann T, Rothstein JD, Jinnah HA. Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. Brain Res Dev Brain Res. 2002 Feb 28; 133(2):127-39. PMID: 11882343.
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    40. Friedmann T. Stanfield Rogers: insights into virus vectors and failure of an early gene therapy model. Mol Ther. 2001 Oct; 4(4):285-8. PMID: 11592829.
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    41. Okimoto T, Friedmann T, Miyanohara A. VSV-G envelope glycoprotein forms complexes with plasmid DNA and MLV retrovirus-like particles in cell-free conditions and enhances DNA transfection. Mol Ther. 2001 Sep; 4(3):232-8. PMID: 11545614.
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    42. Friedmann T, Noguchi P, Mickelson C. The evolution of public review and oversight mechanisms in human gene transfer research: joint roles of the FDA and NIH. Curr Opin Biotechnol. 2001 Jun; 12(3):304-7. PMID: 11404110.
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    43. Friedmann T, Koss JO. Gene transfer and athletics- an impending problem. Mol Ther. 2001 Jun; 3(6):819-20. PMID: 11407894.
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    44. Sharma S, Miyanohara A, Friedmann T. Separable mechanisms of attachment and cell uptake during retrovirus infection. J Virol. 2000 Nov; 74(22):10790-5. PMID: 11044124.
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    45. Smith DW, Friedmann T. Characterization of the dopamine defect in primary cultures of dopaminergic neurons from hypoxanthine phosphoribosyltransferase knockout mice. Mol Ther. 2000 May; 1(5 Pt 1):486-91. PMID: 10933970.
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    46. Friedmann T. Medical ethics. Principles for human gene therapy studies. Science. 2000 Mar 24; 287(5461):2163-5. PMID: 10744537.
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    47. Friedmann T. Changing roles for academia and industry in genetics and gene therapy. Mol Ther. 2000 Jan; 1(1):9-11. PMID: 10933906.
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    48. Buchschacher GL, Yu L, Murai F, Friedmann T, Miyanohara A. Association of murine leukemia virus pol with virions, independent of Gag-Pol expression. J Virol. 1999 Nov; 73(11):9632-7. PMID: 10516075.
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    49. Wojcik BE, Jinnah HA, Muller-Sieburg CE, Friedmann T. Bone marrow transplantation does not ameliorate the neurologic symptoms in mice deficient in hypoxanthine guanine phosphoribosyl transferase (HPRT). Metab Brain Dis. 1999 Mar; 14(1):57-65. PMID: 10348314.
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    50. Abe A, Chen ST, Miyanohara A, Friedmann T. In vitro cell-free conversion of noninfectious Moloney retrovirus particles to an infectious form by the addition of the vesicular stomatitis virus surrogate envelope G protein. J Virol. 1998 Aug; 72(8):6356-61. PMID: 9658075.
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    51. Abe A, Miyanohara A, Friedmann T. Enhanced gene transfer with fusogenic liposomes containing vesicular stomatitis virus G glycoprotein. J Virol. 1998 Jul; 72(7):6159-63. PMID: 9621082.
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    52. Abe A, Miyanohara A, Friedmann T. Polybrene increases the efficiency of gene transfer by lipofection. Gene Ther. 1998 May; 5(5):708-11. PMID: 9797877.
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    53. Friedmann T. The road toward human gene therapy--a 25-year perspective. Ann Med. 1997 Dec; 29(6):575-7. PMID: 9562527.
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    54. Sharma S, Murai F, Miyanohara A, Friedmann T. Noninfectious virus-like particles produced by Moloney murine leukemia virus-based retrovirus packaging cells deficient in viral envelope become infectious in the presence of lipofection reagents. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10803-8. PMID: 9380714.
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    55. Friedmann T. Overcoming the obstacles to gene therapy. Sci Am. 1997 Jun; 276(6):96-101. PMID: 9163941.
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    56. Cantwell MJ, Sharma S, Friedmann T, Kipps TJ. Adenovirus vector infection of chronic lymphocytic leukemia B cells. Blood. 1996 Dec 15; 88(12):4676-83. PMID: 8977261.
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    57. Friedmann T. The maturation of human gene therapy. Acta Paediatr. 1996 Nov; 85(11):1261-5. PMID: 8955449.
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    58. Sharma S, Cantwell M, Kipps TJ, Friedmann T. Efficient infection of a human T-cell line and of human primary peripheral blood leukocytes with a pseudotyped retrovirus vector. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11842-7. PMID: 8876225.
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    59. Chen ST, Iida A, Guo L, Friedmann T, Yee JK. Generation of packaging cell lines for pseudotyped retroviral vectors of the G protein of vesicular stomatitis virus by using a modified tetracycline inducible system. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10057-62. PMID: 8816750.
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    60. Kurdi-Haidar B, Friedmann T. Simplified plasmid rescue of host sequences adjacent to integrated proviruses. Gene. 1996 Feb 12; 168(2):199-203. PMID: 8654944.
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    61. Friedmann T. Human gene therapy--an immature genie, but certainly out of the bottle. Nat Med. 1996 Feb; 2(2):144-7. PMID: 8574951.
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    62. Wang MJ, Friedmann T, Johnson PA. Differentiation of PC12 cells by infection with an HSV-1 vector expressing nerve growth factor. Gene Ther. 1995 Jul; 2(5):323-35. PMID: 7671108.
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    63. Benz DJ, Mol M, Ezaki M, Mori-Ito N, Zelán I, Miyanohara A, Friedmann T, Parthasarathy S, Steinberg D, Witztum JL. Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase. J Biol Chem. 1995 Mar 10; 270(10):5191-7. PMID: 7890629.
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    64. Miyanohara A, Yee JK, Bouic K, LaPorte P, Friedmann T. Efficient in vivo transduction of the neonatal mouse liver with pseudotyped retroviral vectors. Gene Ther. 1995 Mar; 2(2):138-42. PMID: 7719930.
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    65. Friedmann T, Yee JK. Pseudotyped retroviral vectors for studies of human gene therapy. Nat Med. 1995 Mar; 1(3):275-7. PMID: 7585046.
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    66. Roemer K, Johnson PA, Friedmann T. Transduction of foreign regulatory sequences by a replication-defective herpes simplex virus type 1: the rat neuron-specific enolase promoter. Virus Res. 1995 Jan; 35(1):81-9. PMID: 7754677.
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    67. Johnson PA, Wang MJ, Friedmann T. Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. J Virol. 1994 Oct; 68(10):6347-62. PMID: 8083974.
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    68. Yee JK, Miyanohara A, LaPorte P, Bouic K, Burns JC, Friedmann T. A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9564-8. PMID: 7937806.
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    69. Burns JC, Matsubara T, Lozinski G, Yee JK, Friedmann T, Washabaugh CH, Tsonis PA. Pantropic retroviral vector-mediated gene transfer, integration, and expression in cultured newt limb cells. Dev Biol. 1994 Sep; 165(1):285-9. PMID: 8088445.
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    70. Friedmann T. Gene therapy for neurological disorders. Trends Genet. 1994 Jun; 10(6):210-4. PMID: 8073535.
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    71. Roemer K, Friedmann T. Mechanisms of action of the p53 tumor suppressor and prospects for cancer gene therapy by reconstitution of p53 function. Ann N Y Acad Sci. 1994 May 31; 716:265-80; discussion 280-2. PMID: 8024199.
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    72. Runnebaum IB, Yee JK, Kieback DG, Sukumar S, Friedmann T. Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles. Anticancer Res. 1994 May-Jun; 14(3A):1137-44. PMID: 8074464.
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    73. Jinnah HA, Wojcik BE, Hunt M, Narang N, Lee KY, Goldstein M, Wamsley JK, Langlais PJ, Friedmann T. Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. J Neurosci. 1994 Mar; 14(3 Pt 1):1164-75. PMID: 7509865.
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    74. Lu M, Maruyama M, Zhang N, Levine F, Friedmann T, Ho AD. High efficiency retroviral-mediated gene transduction into CD34+ cells purified from peripheral blood of breast cancer patients primed with chemotherapy and granulocyte-macrophage colony-stimulating factor. Hum Gene Ther. 1994 Feb; 5(2):203-8. PMID: 7514449.
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    75. Johnson PA, Friedmann T. Replication-defective recombinant herpes simplex virus vectors. Methods Cell Biol. 1994; 43 Pt A:211-30. PMID: 7823863.
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    76. Friedmann T. Gene therapy for disorders of the CNS. Gene Ther. 1994; 1 Suppl 1:S47-8. PMID: 8542395.
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    77. Levine F, Friedmann T. Gene therapy. Am J Dis Child. 1993 Nov; 147(11):1167-74. PMID: 8237910.
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    78. Roemer K, Friedmann T. Modulation of cell proliferation and gene expression by a p53-estrogen receptor hybrid protein. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9252-6. PMID: 8415687.
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    79. Burns JC, Friedmann T, Driever W, Burrascano M, Yee JK. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc Natl Acad Sci U S A. 1993 Sep 01; 90(17):8033-7. PMID: 8396259.
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    80. Jinnah HA, Page T, Friedmann T. Brain purines in a genetic mouse model of Lesch-Nyhan disease. J Neurochem. 1993 Jun; 60(6):2036-45. PMID: 8492116.
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    81. Friedmann T, Jinnah HA. Gene therapy for disorders of the nervous system. Trends Biotechnol. 1993 May; 11(5):192-7. PMID: 7763810.
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    82. Friedmann T. Gene therapy--a new kind of medicine. Trends Biotechnol. 1993 May; 11(5):156-9. PMID: 7763803.
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    83. Kurdi-Haidar B, Levine F, Roemer K, LaPorte P, Friedmann T. Provirus-anchored long-range (PAL) mapping of mammalian genomes. Genomics. 1993 Feb; 15(2):305-10. PMID: 8449495.
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    84. Friedmann T. Milestone and events in the early development of human gene therapy. Mol Genet Med. 1993; 3:1-32. PMID: 8220161.
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    85. Jinnah HA, Langlais PJ, Friedmann T. Functional analysis of brain dopamine systems in a genetic mouse model of Lesch-Nyhan syndrome. J Pharmacol Exp Ther. 1992 Nov; 263(2):596-607. PMID: 1432691.
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    86. Friedmann T. Approaches to gene therapy of complex multigenic diseases: cancer as a model and implications for cardiovascular disease and diabetes. Ann Med. 1992 Oct; 24(5):411-7. PMID: 1418928.
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    87. Friedmann T. A brief history of gene therapy. Nat Genet. 1992 Oct; 2(2):93-8. PMID: 1303270.
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    88. Friedmann T. Gene therapy of cancer through restoration of tumor-suppressor functions? Cancer. 1992 Sep 15; 70(6 Suppl):1810-7. PMID: 1516033.
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    89. Roemer K, Friedmann T. Concepts and strategies for human gene therapy. Eur J Biochem. 1992 Sep 01; 208(2):211-25. PMID: 1521521.
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    90. Roemer K, Johnson PA, Friedmann T. Recombination between a herpes simplex virus type 1 vector deleted for immediate early gene 3 and the infected cell genome. J Gen Virol. 1992 Jun; 73 ( Pt 6):1553-8. PMID: 1318949.
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    91. Schinstine M, Rosenberg MB, Routledge-Ward C, Friedmann T, Gage FH. Effects of choline and quiescence on Drosophila choline acetyltransferase expression and acetylcholine production by transduced rat fibroblasts. J Neurochem. 1992 Jun; 58(6):2019-29. PMID: 1573390.
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    92. Roman M, Axelrod JH, Dai Y, Naviaux RK, Friedmann T, Verma IM. Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle. Somat Cell Mol Genet. 1992 May; 18(3):247-58. PMID: 1496420.
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    93. Johnson PA, Miyanohara A, Levine F, Cahill T, Friedmann T. Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1. J Virol. 1992 May; 66(5):2952-65. PMID: 1373198.
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    94. Miyanohara A, Johnson PA, Elam RL, Dai Y, Witztum JL, Verma IM, Friedmann T. Direct gene transfer to the liver with herpes simplex virus type 1 vectors: transient production of physiologically relevant levels of circulating factor IX. New Biol. 1992 Mar; 4(3):238-46. PMID: 1316145.
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    95. Miyanohara A, Elam RL, Witztum JL, Friedmann T. Long-term transgene expression from genetically modified hepatocytes grafted to the rat liver. New Biol. 1992 Mar; 4(3):261-7. PMID: 1581292.
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    96. Jinnah HA, Hess EJ, Wilson MC, Gage FH, Friedmann T. Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization. Mol Cell Neurosci. 1992 Feb; 3(1):64-78. PMID: 19912847.
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    97. Johnson PA, Yoshida K, Gage FH, Friedmann T. Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector. Brain Res Mol Brain Res. 1992 Jan; 12(1-3):95-102. PMID: 1312210.
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    98. Cheng J, Yee JK, Yeargin J, Friedmann T, Haas M. Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene. Cancer Res. 1992 Jan 01; 52(1):222-6. PMID: 1727382.
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    99. Levine F, Yee JK, Friedmann T. Efficient gene expression in mammalian cells from a dicistronic transcriptional unit in an improved retroviral vector. Gene. 1991 Dec 15; 108(2):167-74. PMID: 1660834.
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    100. Jinnah HA, Gage FH, Friedmann T. Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome. Behav Neurosci. 1991 Dec; 105(6):1004-12. PMID: 1777100.
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    101. Roemer K, Johnson PA, Friedmann T. Activity of the simian virus 40 early promoter-enhancer in herpes simplex virus type 1 vectors is dependent on its position, the infected cell type, and the presence of Vmw175. J Virol. 1991 Dec; 65(12):6900-12. PMID: 1658381.
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    102. Levine F, Friedmann T. Gene therapy techniques. Curr Opin Biotechnol. 1991 Dec; 2(6):840-4. PMID: 1367958.
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    103. Friedmann T. Genetically modified tumor-infiltrating lymphocytes for cancer therapy. Cancer Cells. 1991 Jul; 3(7):271-4. PMID: 1911040.
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    104. Roemer K, Johnson PA, Friedmann T. Knock-in and knock-out. Transgenes, Development and Disease: A Keystone Symposium sponsored by Genentech and Immunex, Tamarron, CO, USA, January 12-18, 1991. New Biol. 1991 Apr; 3(4):331-5. PMID: 2065017.
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    105. Emi N, Friedmann T, Yee JK. Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus. J Virol. 1991 Mar; 65(3):1202-7. PMID: 1847450.
      View in: PubMed
    106. Johnson PA, Best MG, Friedmann T, Parris DS. Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype. J Virol. 1991 Feb; 65(2):700-10. PMID: 1846193.
      View in: PubMed
    107. Sharkey MF, Miyanohara A, Elam RL, Friedmann T, Witztum JL. Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity. J Lipid Res. 1990 Dec; 31(12):2167-78. PMID: 2090710.
      View in: PubMed
    108. Jinnah HA, Gage FH, Friedmann T. Animal models of Lesch-Nyhan syndrome. Brain Res Bull. 1990 Sep; 25(3):467-75. PMID: 2292045.
      View in: PubMed
    109. Johnson P, Friedmann T. Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK. Gene. 1990 Apr 16; 88(2):207-13. PMID: 2347494.
      View in: PubMed
    110. Friedmann T. The human genome project--some implications of extensive "reverse genetic" medicine. Am J Hum Genet. 1990 Mar; 46(3):407-14. PMID: 2309696.
      View in: PubMed
    111. Friedmann T. The evolving concept of gene therapy. Hum Gene Ther. 1990; 1(2):175-81. PMID: 2078579.
      View in: PubMed
    112. Gage FH, Fisher LJ, Jinnah HA, Rosenberg MB, Tuszynski MH, Friedmann T. Grafting genetically modified cells to the brain: conceptual and technical issues. Prog Brain Res. 1990; 82:1-10. PMID: 1981271.
      View in: PubMed
    113. Gage FH, Rosenberg MB, Tuszynski MH, Yoshida K, Armstrong DM, Hayes RC, Friedmann T. Gene therapy in the CNS: intracerebral grafting of genetically modified cells. Prog Brain Res. 1990; 86:205-17. PMID: 2087558.
      View in: PubMed
    114. Xu L, Yee JK, Wolff JA, Friedmann T. Factors affecting long-term stability of Moloney murine leukemia virus-based vectors. Virology. 1989 Aug; 171(2):331-41. PMID: 2503932.
      View in: PubMed
    115. Friedmann T. Progress toward human gene therapy. Science. 1989 Jun 16; 244(4910):1275-81. PMID: 2660259.
      View in: PubMed
    116. Shimohama S, Rosenberg MB, Fagan AM, Wolff JA, Short MP, Breakefield XO, Friedmann T, Gage FH. Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene. Brain Res Mol Brain Res. 1989 Jun; 5(4):271-8. PMID: 2501628.
      View in: PubMed
    117. Friedmann T, Xu L, Wolff J, Yee JK, Miyanohara A. Retrovirus vector-mediated gene transfer into hepatocytes. Mol Biol Med. 1989 Apr; 6(2):117-25. PMID: 2693887.
      View in: PubMed
    118. Huang HJ, Yee JK, Shew JY, Chen PL, Bookstein R, Friedmann T, Lee EY, Lee WH. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science. 1988 Dec 16; 242(4885):1563-6. PMID: 3201247.
      View in: PubMed
    119. Miyanohara A, Sharkey MF, Witztum JL, Steinberg D, Friedmann T. Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitro. Proc Natl Acad Sci U S A. 1988 Sep; 85(17):6538-42. PMID: 2842777.
      View in: PubMed
    120. Bookstein R, Lee EY, To H, Young LJ, Sery TW, Hayes RC, Friedmann T, Lee WH. Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2210-4. PMID: 2895471.
      View in: PubMed
    121. Friedmann T. Applications and implications of genome related biotechnology. Basic Life Sci. 1988; 46:149-59. PMID: 3223869.
      View in: PubMed
    122. Gage FH, Wolff JA, Rosenberg MB, Xu L, Yee JK, Shults C, Friedmann T. Grafting genetically modified cells to the brain: possibilities for the future. Neuroscience. 1987 Dec; 23(3):795-807. PMID: 3325854.
      View in: PubMed
    123. Wolff JA, Yee JK, Skelly H, Moores J, Respess J, Friedmann T, Leffert H. Adult mammalian hepatocyte as target cell for retroviral gene transfer: a model for gene therapy. Somat Cell Mol Genet. 1987 Jul; 13(4):423-8. PMID: 3484086.
      View in: PubMed