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Genetic therapies, human genetic enhancement, and … eugenics? Gene Ther. 2019 09; 26(9):351-353.
Friedmann T. PMID: 31273325.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Gene therapy for spinomuscular atrophy: a biomedical advance, a missed opportunity for more equitable drug pricing. Gene Ther. 2017 09; 24(9):503-505.
Friedmann T. PMID: 28639617.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
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ASGCT and JSGT Joint Position Statement on Human Genomic Editing. Mol Ther. 2015 Aug; 23(8):1282.
Friedmann T, Jonlin EC, King NMP, Torbett BE, Wivel NA, Kaneda Y, Sadelain M. PMID: 26227250; PMCID: PMC4817859.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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The housekeeping gene hypoxanthine guanine phosphoribosyltransferase (HPRT) regulates multiple developmental and metabolic pathways of murine embryonic stem cell neuronal differentiation. PLoS One. 2013; 8(10):e74967.
Kang TH, Park Y, Bader JS, Friedmann T. PMID: 24130677; PMCID: PMC3794013.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Evolving concepts and techniques for anti-doping. Bioanalysis. 2012 Jul; 4(13):1667-80.
Friedmann T, Flenker U, Georgakopoulos C, Alsayrafi M, Sottas PE, Williams SA, Gill RD. PMID: 22831482.
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PubMed Mentions: Fields:
Translation:
HumansPHPublic Health
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Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3377-82.
Mastrangelo L, Kim JE, Miyanohara A, Kang TH, Friedmann T. PMID: 22331909; PMCID: PMC3295269.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
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MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch-Nyhan disease? Hum Mol Genet. 2012 Feb 01; 21(3):609-22.
Guibinga GH, Hrustanovic G, Bouic K, Jinnah HA, Friedmann T. PMID: 22042773; PMCID: PMC3259014.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11; 58(16):1715-27.
Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL. PMID: 21982317; PMCID: PMC3230644.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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HPRT deficiency coordinately dysregulates canonical Wnt and presenilin-1 signaling: a neuro-developmental regulatory role for a housekeeping gene? PLoS One. 2011 Jan 28; 6(1):e16572.
Kang TH, Guibinga GH, Jinnah HA, Friedmann T. PMID: 21305049; PMCID: PMC3030599.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCells
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How close are we to gene doping? Hastings Cent Rep. 2010 Mar-Apr; 40(2):20-2.
Friedmann T. PMID: 20391845.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
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Ethics. Gene doping and sport. Science. 2010 Feb 05; 327(5966):647-8.
Friedmann T, Rabin O, Frankel MS. PMID: 20133558.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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A fractionation method to identify qauntitative changes in protein expression mediated by IGF-1 on the proteome of murine C2C12 myoblasts. Proteome Sci. 2009 Aug 11; 7:28.
King CC, Bouic K, Friedmann T. PMID: 19664293; PMCID: PMC2732595.
View in:
PubMed Mentions:
2
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Deficiency of the housekeeping gene hypoxanthine-guanine phosphoribosyltransferase (HPRT) dysregulates neurogenesis. Mol Ther. 2010 Jan; 18(1):54-62.
Guibinga GH, Hsu S, Friedmann T. PMID: 19672249; PMCID: PMC2839227.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts. BMC Genomics. 2008 Nov 11; 9:535.
Bhasker CR, Friedmann T. PMID: 19014463; PMCID: PMC2628395.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Characterization of the gene delivery properties of baculoviral-based virosomal vectors. J Virol Methods. 2008 Mar; 148(1-2):277-82.
Guibinga GH, Song S, Loring J, Friedmann T. PMID: 18207578.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Partial characterization of the proteome of the mouse striatum. Proteomics. 2007 Nov; 7(21):3867-9.
Guo LT, Friedmann T, King CC. PMID: 17922512.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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A decade of accomplishments: gene therapy and the ASGT. Mol Ther. 2007 Sep; 15(9):1576-8.
Friedmann T. PMID: 17710079.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
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Tissue-specific aberrations of gene expression in HPRT-deficient mice: functional complexity in a monogenic disease? Mol Ther. 2007 Aug; 15(8):1432-43.
Song S, Friedmann T. PMID: 17505472.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Baculovirus GP64-pseudotyped HIV-based lentivirus vectors are stabilized against complement inactivation by codisplay of decay accelerating factor (DAF) or of a GP64-DAF fusion protein. Mol Ther. 2005 Apr; 11(4):645-51.
Guibinga GH, Friedmann T. PMID: 15771967.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Lessons for the stem cell discourse from the gene therapy experience. Perspect Biol Med. 2005; 48(4):585-91.
Friedmann T. PMID: 16227669.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
Clinical gene therapy: lessons from the ether dome. Mol Ther. 2004 Aug; 10(2):205-6.
Friedmann T. PMID: 15294165.
View in:
PubMed Mentions: Fields:
Translation:
Humans
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Discrepant effects of culture conditions on survival and function of dopaminergic neurons. Neuroreport. 2004 Apr 29; 15(6):1025-8.
Smith DW, Friedmann T. PMID: 15076727.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Ligand-modified vesicular stomatitis virus glycoprotein displays a temperature-sensitive intracellular trafficking and virus assembly phenotype. Mol Ther. 2004 Jan; 9(1):76-84.
Guibinga GH, Hall FL, Gordon EM, Ruoslahti E, Friedmann T. PMID: 14741780.
View in:
PubMed Mentions:
15 Fields:
Translation:
Cells
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Gene therapy's new era: a balance of unequivocal benefit and unequivocal harm. Mol Ther. 2003 Jul; 8(1):5-7.
Friedmann T. PMID: 12872762.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
Cell surface heparan sulfate is a receptor for attachment of envelope protein-free retrovirus-like particles and VSV-G pseudotyped MLV-derived retrovirus vectors to target cells. Mol Ther. 2002 May; 5(5 Pt 1):538-46.
Guibinga GH, Miyanohara A, Esko JD, Friedmann T. PMID: 11991744.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Stanfield Rogers: insights into virus vectors and failure of an early gene therapy model. Mol Ther. 2001 Oct; 4(4):285-8.
Friedmann T. PMID: 11592829.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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VSV-G envelope glycoprotein forms complexes with plasmid DNA and MLV retrovirus-like particles in cell-free conditions and enhances DNA transfection. Mol Ther. 2001 Sep; 4(3):232-8.
Okimoto T, Friedmann T, Miyanohara A. PMID: 11545614.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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The evolution of public review and oversight mechanisms in human gene transfer research: joint roles of the FDA and NIH. Curr Opin Biotechnol. 2001 Jun; 12(3):304-7.
Friedmann T, Noguchi P, Mickelson C. PMID: 11404110.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
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Gene transfer and athletics- an impending problem. Mol Ther. 2001 Jun; 3(6):819-20.
Friedmann T, Koss JO. PMID: 11407894.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
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Separable mechanisms of attachment and cell uptake during retrovirus infection. J Virol. 2000 Nov; 74(22):10790-5.
Sharma S, Miyanohara A, Friedmann T. PMID: 11044124; PMCID: PMC110954.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Characterization of the dopamine defect in primary cultures of dopaminergic neurons from hypoxanthine phosphoribosyltransferase knockout mice. Mol Ther. 2000 May; 1(5 Pt 1):486-91.
Smith DW, Friedmann T. PMID: 10933970.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Medical ethics. Principles for human gene therapy studies. Science. 2000 Mar 24; 287(5461):2163-5.
Friedmann T. PMID: 10744537.
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PubMed Mentions:
3 Fields:
Translation:
Humans
-
Changing roles for academia and industry in genetics and gene therapy. Mol Ther. 2000 Jan; 1(1):9-11.
Friedmann T. PMID: 10933906.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Association of murine leukemia virus pol with virions, independent of Gag-Pol expression. J Virol. 1999 Nov; 73(11):9632-7.
Buchschacher GL, Yu L, Murai F, Friedmann T, Miyanohara A. PMID: 10516075; PMCID: PMC113001.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Bone marrow transplantation does not ameliorate the neurologic symptoms in mice deficient in hypoxanthine guanine phosphoribosyl transferase (HPRT). Metab Brain Dis. 1999 Mar; 14(1):57-65.
Wojcik BE, Jinnah HA, Muller-Sieburg CE, Friedmann T. PMID: 10348314.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
In vitro cell-free conversion of noninfectious Moloney retrovirus particles to an infectious form by the addition of the vesicular stomatitis virus surrogate envelope G protein. J Virol. 1998 Aug; 72(8):6356-61.
Abe A, Chen ST, Miyanohara A, Friedmann T. PMID: 9658075; PMCID: PMC109781.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Enhanced gene transfer with fusogenic liposomes containing vesicular stomatitis virus G glycoprotein. J Virol. 1998 Jul; 72(7):6159-63.
Abe A, Miyanohara A, Friedmann T. PMID: 9621082; PMCID: PMC110424.
View in:
PubMed Mentions:
14 Fields:
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Polybrene increases the efficiency of gene transfer by lipofection. Gene Ther. 1998 May; 5(5):708-11.
Abe A, Miyanohara A, Friedmann T. PMID: 9797877.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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The road toward human gene therapy--a 25-year perspective. Ann Med. 1997 Dec; 29(6):575-7.
Friedmann T. PMID: 9562527.
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PubMed Mentions: Fields:
Translation:
Humans
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Noninfectious virus-like particles produced by Moloney murine leukemia virus-based retrovirus packaging cells deficient in viral envelope become infectious in the presence of lipofection reagents. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10803-8.
Sharma S, Murai F, Miyanohara A, Friedmann T. PMID: 9380714; PMCID: PMC23491.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Overcoming the obstacles to gene therapy. Sci Am. 1997 Jun; 276(6):96-101.
Friedmann T. PMID: 9163941.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Adenovirus vector infection of chronic lymphocytic leukemia B cells. Blood. 1996 Dec 15; 88(12):4676-83.
Cantwell MJ, Sharma S, Friedmann T, Kipps TJ. PMID: 8977261.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCells
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The maturation of human gene therapy. Acta Paediatr. 1996 Nov; 85(11):1261-5.
Friedmann T. PMID: 8955449.
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
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Efficient infection of a human T-cell line and of human primary peripheral blood leukocytes with a pseudotyped retrovirus vector. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11842-7.
Sharma S, Cantwell M, Kipps TJ, Friedmann T. PMID: 8876225; PMCID: PMC38146.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Generation of packaging cell lines for pseudotyped retroviral vectors of the G protein of vesicular stomatitis virus by using a modified tetracycline inducible system. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10057-62.
Chen ST, Iida A, Guo L, Friedmann T, Yee JK. PMID: 8816750; PMCID: PMC38335.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Simplified plasmid rescue of host sequences adjacent to integrated proviruses. Gene. 1996 Feb 12; 168(2):199-203.
Kurdi-Haidar B, Friedmann T. PMID: 8654944.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Human gene therapy--an immature genie, but certainly out of the bottle. Nat Med. 1996 Feb; 2(2):144-7.
Friedmann T. PMID: 8574951.
View in:
PubMed Mentions:
13 Fields:
Translation:
Humans
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Differentiation of PC12 cells by infection with an HSV-1 vector expressing nerve growth factor. Gene Ther. 1995 Jul; 2(5):323-35.
Wang MJ, Friedmann T, Johnson PA. PMID: 7671108.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase. J Biol Chem. 1995 Mar 10; 270(10):5191-7.
Benz DJ, Mol M, Ezaki M, Mori-Ito N, Zelán I, Miyanohara A, Friedmann T, Parthasarathy S, Steinberg D, Witztum JL. PMID: 7890629.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Pseudotyped retroviral vectors for studies of human gene therapy. Nat Med. 1995 Mar; 1(3):275-7.
Friedmann T, Yee JK. PMID: 7585046.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Efficient in vivo transduction of the neonatal mouse liver with pseudotyped retroviral vectors. Gene Ther. 1995 Mar; 2(2):138-42.
Miyanohara A, Yee JK, Bouic K, LaPorte P, Friedmann T. PMID: 7719930.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Transduction of foreign regulatory sequences by a replication-defective herpes simplex virus type 1: the rat neuron-specific enolase promoter. Virus Res. 1995 Jan; 35(1):81-9.
Roemer K, Johnson PA, Friedmann T. PMID: 7754677.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. J Virol. 1994 Oct; 68(10):6347-62.
Johnson PA, Wang MJ, Friedmann T. PMID: 8083974; PMCID: PMC237056.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9564-8.
Yee JK, Miyanohara A, LaPorte P, Bouic K, Burns JC, Friedmann T. PMID: 7937806; PMCID: PMC44853.
View in:
PubMed Mentions:
193 Fields:
Translation:
HumansAnimalsCells
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Pantropic retroviral vector-mediated gene transfer, integration, and expression in cultured newt limb cells. Dev Biol. 1994 Sep; 165(1):285-9.
Burns JC, Matsubara T, Lozinski G, Yee JK, Friedmann T, Washabaugh CH, Tsonis PA. PMID: 8088445.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Gene therapy for neurological disorders. Trends Genet. 1994 Jun; 10(6):210-4.
Friedmann T. PMID: 8073535.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Mechanisms of action of the p53 tumor suppressor and prospects for cancer gene therapy by reconstitution of p53 function. Ann N Y Acad Sci. 1994 May 31; 716:265-80; discussion 280-2.
Roemer K, Friedmann T. PMID: 8024199.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles. Anticancer Res. 1994 May-Jun; 14(3A):1137-44.
Runnebaum IB, Yee JK, Kieback DG, Sukumar S, Friedmann T. PMID: 8074464.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. J Neurosci. 1994 Mar; 14(3 Pt 1):1164-75.
Jinnah HA, Wojcik BE, Hunt M, Narang N, Lee KY, Goldstein M, Wamsley JK, Langlais PJ, Friedmann T. PMID: 7509865; PMCID: PMC6577527.
View in:
PubMed Mentions:
43 Fields:
Translation:
Animals
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High efficiency retroviral-mediated gene transduction into CD34+ cells purified from peripheral blood of breast cancer patients primed with chemotherapy and granulocyte-macrophage colony-stimulating factor. Hum Gene Ther. 1994 Feb; 5(2):203-8.
Lu M, Maruyama M, Zhang N, Levine F, Friedmann T, Ho AD. PMID: 7514449.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Replication-defective recombinant herpes simplex virus vectors. Methods Cell Biol. 1994; 43 Pt A:211-30.
Johnson PA, Friedmann T. PMID: 7823863.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Gene therapy for disorders of the CNS. Gene Ther. 1994; 1 Suppl 1:S47-8.
Friedmann T. PMID: 8542395.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Gene therapy. Am J Dis Child. 1993 Nov; 147(11):1167-74.
Levine F, Friedmann T. PMID: 8237910.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Modulation of cell proliferation and gene expression by a p53-estrogen receptor hybrid protein. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9252-6.
Roemer K, Friedmann T. PMID: 8415687; PMCID: PMC47545.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc Natl Acad Sci U S A. 1993 Sep 01; 90(17):8033-7.
Burns JC, Friedmann T, Driever W, Burrascano M, Yee JK. PMID: 8396259; PMCID: PMC47282.
View in:
PubMed Mentions:
407 Fields:
Translation:
HumansAnimalsCells
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Brain purines in a genetic mouse model of Lesch-Nyhan disease. J Neurochem. 1993 Jun; 60(6):2036-45.
Jinnah HA, Page T, Friedmann T. PMID: 8492116.
View in:
PubMed Mentions:
17 Fields:
Translation:
Animals
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Gene therapy--a new kind of medicine. Trends Biotechnol. 1993 May; 11(5):156-9.
Friedmann T. PMID: 7763803.
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PubMed Mentions: Fields:
Translation:
Humans
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Gene therapy for disorders of the nervous system. Trends Biotechnol. 1993 May; 11(5):192-7.
Friedmann T, Jinnah HA. PMID: 7763810.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Provirus-anchored long-range (PAL) mapping of mammalian genomes. Genomics. 1993 Feb; 15(2):305-10.
Kurdi-Haidar B, Levine F, Roemer K, LaPorte P, Friedmann T. PMID: 8449495.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Milestone and events in the early development of human gene therapy. Mol Genet Med. 1993; 3:1-32.
Friedmann T. PMID: 8220161.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Functional analysis of brain dopamine systems in a genetic mouse model of Lesch-Nyhan syndrome. J Pharmacol Exp Ther. 1992 Nov; 263(2):596-607.
Jinnah HA, Langlais PJ, Friedmann T. PMID: 1432691.
View in:
PubMed Mentions:
24 Fields:
Translation:
Animals
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A brief history of gene therapy. Nat Genet. 1992 Oct; 2(2):93-8.
Friedmann T. PMID: 1303270.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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Approaches to gene therapy of complex multigenic diseases: cancer as a model and implications for cardiovascular disease and diabetes. Ann Med. 1992 Oct; 24(5):411-7.
Friedmann T. PMID: 1418928.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Gene therapy of cancer through restoration of tumor-suppressor functions? Cancer. 1992 Sep 15; 70(6 Suppl):1810-7.
Friedmann T. PMID: 1516033.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Concepts and strategies for human gene therapy. Eur J Biochem. 1992 Sep 01; 208(2):211-25.
Roemer K, Friedmann T. PMID: 1521521.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Effects of choline and quiescence on Drosophila choline acetyltransferase expression and acetylcholine production by transduced rat fibroblasts. J Neurochem. 1992 Jun; 58(6):2019-29.
Schinstine M, Rosenberg MB, Routledge-Ward C, Friedmann T, Gage FH. PMID: 1573390.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Recombination between a herpes simplex virus type 1 vector deleted for immediate early gene 3 and the infected cell genome. J Gen Virol. 1992 Jun; 73 ( Pt 6):1553-8.
Roemer K, Johnson PA, Friedmann T. PMID: 1318949.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle. Somat Cell Mol Genet. 1992 May; 18(3):247-58.
Roman M, Axelrod JH, Dai Y, Naviaux RK, Friedmann T, Verma IM. PMID: 1496420.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1. J Virol. 1992 May; 66(5):2952-65.
Johnson PA, Miyanohara A, Levine F, Cahill T, Friedmann T. PMID: 1373198; PMCID: PMC241054.
View in:
PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Direct gene transfer to the liver with herpes simplex virus type 1 vectors: transient production of physiologically relevant levels of circulating factor IX. New Biol. 1992 Mar; 4(3):238-46.
Miyanohara A, Johnson PA, Elam RL, Dai Y, Witztum JL, Verma IM, Friedmann T. PMID: 1316145.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Long-term transgene expression from genetically modified hepatocytes grafted to the rat liver. New Biol. 1992 Mar; 4(3):261-7.
Miyanohara A, Elam RL, Witztum JL, Friedmann T. PMID: 1581292.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization. Mol Cell Neurosci. 1992 Feb; 3(1):64-78.
Jinnah HA, Hess EJ, Wilson MC, Gage FH, Friedmann T. PMID: 19912847.
View in:
PubMed Mentions:
10 Fields:
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Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene. Cancer Res. 1992 Jan 01; 52(1):222-6.
Cheng J, Yee JK, Yeargin J, Friedmann T, Haas M. PMID: 1727382.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector. Brain Res Mol Brain Res. 1992 Jan; 12(1-3):95-102.
Johnson PA, Yoshida K, Gage FH, Friedmann T. PMID: 1312210.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Efficient gene expression in mammalian cells from a dicistronic transcriptional unit in an improved retroviral vector. Gene. 1991 Dec 15; 108(2):167-74.
Levine F, Yee JK, Friedmann T. PMID: 1660834.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Gene therapy techniques. Curr Opin Biotechnol. 1991 Dec; 2(6):840-4.
Levine F, Friedmann T. PMID: 1367958.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Activity of the simian virus 40 early promoter-enhancer in herpes simplex virus type 1 vectors is dependent on its position, the infected cell type, and the presence of Vmw175. J Virol. 1991 Dec; 65(12):6900-12.
Roemer K, Johnson PA, Friedmann T. PMID: 1658381; PMCID: PMC250792.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome. Behav Neurosci. 1991 Dec; 105(6):1004-12.
Jinnah HA, Gage FH, Friedmann T. PMID: 1777100.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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Genetically modified tumor-infiltrating lymphocytes for cancer therapy. Cancer Cells. 1991 Jul; 3(7):271-4.
Friedmann T. PMID: 1911040.
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HumansCells
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Knock-in and knock-out. Transgenes, Development and Disease: A Keystone Symposium sponsored by Genentech and Immunex, Tamarron, CO, USA, January 12-18, 1991. New Biol. 1991 Apr; 3(4):331-5.
Roemer K, Johnson PA, Friedmann T. PMID: 2065017.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus. J Virol. 1991 Mar; 65(3):1202-7.
Emi N, Friedmann T, Yee JK. PMID: 1847450; PMCID: PMC239887.
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PubMed Mentions:
95 Fields:
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HumansAnimalsCells
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Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype. J Virol. 1991 Feb; 65(2):700-10.
Johnson PA, Best MG, Friedmann T, Parris DS. PMID: 1846193; PMCID: PMC239809.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity. J Lipid Res. 1990 Dec; 31(12):2167-78.
Sharkey MF, Miyanohara A, Elam RL, Friedmann T, Witztum JL. PMID: 2090710.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Animal models of Lesch-Nyhan syndrome. Brain Res Bull. 1990 Sep; 25(3):467-75.
Jinnah HA, Gage FH, Friedmann T. PMID: 2292045.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK. Gene. 1990 Apr 16; 88(2):207-13.
Johnson P, Friedmann T. PMID: 2347494.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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The human genome project--some implications of extensive "reverse genetic" medicine. Am J Hum Genet. 1990 Mar; 46(3):407-14.
Friedmann T. PMID: 2309696; PMCID: PMC1683631.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Gene therapy in the CNS: intracerebral grafting of genetically modified cells. Prog Brain Res. 1990; 86:205-17.
Gage FH, Rosenberg MB, Tuszynski MH, Yoshida K, Armstrong DM, Hayes RC, Friedmann T. PMID: 2087558.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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The evolving concept of gene therapy. Hum Gene Ther. 1990; 1(2):175-81.
Friedmann T. PMID: 2078579.
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Humans
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Grafting genetically modified cells to the brain: conceptual and technical issues. Prog Brain Res. 1990; 82:1-10.
Gage FH, Fisher LJ, Jinnah HA, Rosenberg MB, Tuszynski MH, Friedmann T. PMID: 1981271.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Factors affecting long-term stability of Moloney murine leukemia virus-based vectors. Virology. 1989 Aug; 171(2):331-41.
Xu L, Yee JK, Wolff JA, Friedmann T. PMID: 2503932.
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PubMed Mentions:
36 Fields:
Translation:
Cells
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Progress toward human gene therapy. Science. 1989 Jun 16; 244(4910):1275-81.
Friedmann T. PMID: 2660259.
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PubMed Mentions:
70 Fields:
Translation:
HumansAnimals
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Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene. Brain Res Mol Brain Res. 1989 Jun; 5(4):271-8.
Shimohama S, Rosenberg MB, Fagan AM, Wolff JA, Short MP, Breakefield XO, Friedmann T, Gage FH. PMID: 2501628.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Retrovirus vector-mediated gene transfer into hepatocytes. Mol Biol Med. 1989 Apr; 6(2):117-25.
Friedmann T, Xu L, Wolff J, Yee JK, Miyanohara A. PMID: 2693887.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science. 1988 Dec 16; 242(4885):1563-6.
Huang HJ, Yee JK, Shew JY, Chen PL, Bookstein R, Friedmann T, Lee EY, Lee WH. PMID: 3201247.
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PubMed Mentions:
185 Fields:
Translation:
HumansCells
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Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitro. Proc Natl Acad Sci U S A. 1988 Sep; 85(17):6538-42.
Miyanohara A, Sharkey MF, Witztum JL, Steinberg D, Friedmann T. PMID: 2842777; PMCID: PMC282008.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2210-4.
Bookstein R, Lee EY, To H, Young LJ, Sery TW, Hayes RC, Friedmann T, Lee WH. PMID: 2895471; PMCID: PMC279959.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Applications and implications of genome related biotechnology. Basic Life Sci. 1988; 46:149-59.
Friedmann T. PMID: 3223869.
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HumansCells
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Grafting genetically modified cells to the brain: possibilities for the future. Neuroscience. 1987 Dec; 23(3):795-807.
Gage FH, Wolff JA, Rosenberg MB, Xu L, Yee JK, Shults C, Friedmann T. PMID: 3325854.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Adult mammalian hepatocyte as target cell for retroviral gene transfer: a model for gene therapy. Somat Cell Mol Genet. 1987 Jul; 13(4):423-8.
Wolff JA, Yee JK, Skelly H, Moores J, Respess J, Friedmann T, Leffert H. PMID: 3484086.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells