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An in vivo neuroimmune organoid model to study human microglia phenotypes. Cell. 2023 05 11; 186(10):2111-2126.e20.
Schafer ST, Mansour AA, Schlachetzki JCM, Pena M, Ghassemzadeh S, Mitchell L, Mar A, Quang D, Stumpf S, Ortiz IS, Lana AJ, Baek C, Zaghal R, Glass CK, Nimmerjahn A, Gage FH. PMID: 37172564; PMCID: PMC10284271.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice. J Exp Med. 2023 02 06; 220(2).
Han RT, Vainchtein ID, Schlachetzki JCM, Cho FS, Dorman LC, Ahn E, Kim DK, Barron JJ, Nakao-Inoue H, Molofsky AB, Glass CK, Paz JT, Molofsky AV. PMID: 36520518; PMCID: PMC9757845.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease. Cell Stem Cell. 2022 12 01; 29(12):1637-1652.e6.
Herdy JR, Traxler L, Agarwal RK, Karbacher L, Schlachetzki JCM, Boehnke L, Zangwill D, Galasko D, Glass CK, Mertens J, Gage FH. PMID: 36459967; PMCID: PMC10093780.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
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TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron. 2023 01 18; 111(2):202-219.e7.
Gratuze M, Schlachetzki JCM, D'Oliveira Albanus R, Jain N, Novotny B, Brase L, Rodriguez L, Mansel C, Kipnis M, O'Brien S, Pasillas MP, Lee C, Manis M, Colonna M, Harari O, Glass CK, Ulrich JD, Holtzman DM. PMID: 36368315; PMCID: PMC9852006.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood. Biol Psychiatry. 2023 05 01; 93(9):770-779.
Ge YJ, Ou YN, Deng YT, Wu BS, Yang L, Zhang YR, Chen SD, Huang YY, Dong Q, Tan L, Yu JT, International FTD-Genomics Consortium. PMID: 36759259.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
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A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice. Elife. 2022 11 08; 11.
Abdel-Haq R, Schlachetzki JCM, Boktor JC, Cantu-Jungles TM, Thron T, Zhang M, Bostick JW, Khazaei T, Chilakala S, Morais LH, Humphrey G, Keshavarzian A, Katz JE, Thomson M, Knight R, Gradinaru V, Hamaker BR, Glass CK, Mazmanian SK. PMID: 36346385; PMCID: PMC9668333.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Human microglia phenotypes in the brain associated with HIV infection. Curr Opin Neurobiol. 2022 Dec; 77:102637.
Schlachetzki JCM, Zhou Y, Glass CK. PMID: 36194988.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy. J Neurosci. 2022 10 05; 42(40):7673-7688.
Battis K, Florio JB, Mante M, Lana A, Naumann I, Gauer C, Lambrecht V, Müller SJ, Cobo I, Fixsen B, Kim HY, Masliah E, Glass CK, Schlachetzki JCM, Rissman RA, Winkler J, Hoffmann A. PMID: 36333098; PMCID: PMC9546481.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning: Dementia Praecox Revisited. JAMA Psychiatry. 2022 09 01; 79(9):907-919.
Koutsouleris N, Pantelis C, Velakoulis D, McGuire P, Dwyer DB, Urquijo-Castro MF, Paul R, Dong S, Popovic D, Oeztuerk O, Kambeitz J, Salokangas RKR, Hietala J, Bertolino A, Brambilla P, Upthegrove R, Wood SJ, Lencer R, Borgwardt S, Maj C, Nöthen M, Degenhardt F, Polyakova M, Mueller K, Villringer A, Danek A, Fassbender K, Fliessbach K, Jahn H, Kornhuber J, Landwehrmeyer B, Anderl-Straub S, Prudlo J, Synofzik M, Wiltfang J, Riedl L, Diehl-Schmid J, Otto M, Meisenzahl E, Falkai P, Schroeter ML, International FTD-Genetics Consortium (IFGC), the German Frontotemporal Lobar Degeneration (FTLD) Co. PMID: 35921104; PMCID: PMC9350851.
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PubMed Mentions: Fields:
Translation:
Humans
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Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. Cell Metab. 2022 09 06; 34(9):1248-1263.e6.
Traxler L, Herdy JR, Stefanoni D, Eichhorner S, Pelucchi S, Szücs A, Santagostino A, Kim Y, Agarwal RK, Schlachetzki JCM, Glass CK, Lagerwall J, Galasko D, Gage FH, D'Alessandro A, Mertens J. PMID: 35987203; PMCID: PMC9458870.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansCells
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DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages. Immunity. 2022 08 09; 55(8):1386-1401.e10.
Cobo I, Tanaka TN, Chandra Mangalhara K, Lana A, Yeang C, Han C, Schlachetzki J, Challcombe J, Fixsen BR, Sakai M, Li RZ, Fields H, Mokry M, Tsai RG, Bejar R, Prange K, de Winther M, Shadel GS, Glass CK. PMID: 35931086; PMCID: PMC9718507.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Somatic mosaicism reveals clonal distributions of neocortical development. Nature. 2022 04; 604(7907):689-696.
Breuss MW, Yang X, Schlachetzki JCM, Antaki D, Lana AJ, Xu X, Chung C, Chai G, Stanley V, Song Q, Newmeyer TF, Nguyen A, O'Brien S, Hoeksema MA, Cao B, Nott A, McEvoy-Venneri J, Pasillas MP, Barton ST, Copeland BR, Nahas S, Van Der Kraan L, Ding Y, NIMH Brain Somatic Mosaicism Network, Glass CK, Gleeson JG. PMID: 35444276; PMCID: PMC9436791.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response. Cell Rep. 2022 03 08; 38(10):110489.
Cobo I, Cheng A, Murillo-Saich J, Coras R, Torres A, Abe Y, Lana AJ, Schlachetzki J, Liu-Bryan R, Terkeltaub R, Sanchez-Lopez E, Glass CK, Guma M. PMID: 35263587; PMCID: PMC8989403.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases. Neural Regen Res. 2021 Sep; 16(9):1711-1714.
Süß P, Lana AJ, Schlachetzki JCM. PMID: 33510059; PMCID: PMC8328777.
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PubMed Mentions:
18
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Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Cell Stem Cell. 2021 09 02; 28(9):1533-1548.e6.
Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Böhnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yang L, Karbacher L, Edenhofer F, Stern S, Horvath S, Paquola ACM, Glass CK, Yuan SH, Ku M, Szücs A, Goldstein LSB, Galasko D, Gage FH. PMID: 33910058; PMCID: PMC8423435.
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PubMed Mentions:
56 Fields:
Translation:
HumansCells
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Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons. Science. 2021 04 02; 372(6537):91-94.
Reid DA, Reed PJ, Schlachetzki JCM, Nitulescu II, Chou G, Tsui EC, Jones JR, Chandran S, Lu AT, McClain CA, Ooi JH, Wang TW, Lana AJ, Linker SB, Ricciardulli AS, Lau S, Schafer ST, Horvath S, Dixon JR, Hah N, Glass CK, Gage FH. PMID: 33795458; PMCID: PMC9179101.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Nuclei isolation of multiple brain cell types for omics interrogation. Nat Protoc. 2021 03; 16(3):1629-1646.
Nott A, Schlachetzki JCM, Fixsen BR, Glass CK. PMID: 33495627; PMCID: PMC7969463.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Gene Expression Imputation Across Multiple Tissue Types Provides Insight Into the Genetic Architecture of Frontotemporal Dementia and Its Clinical Subtypes. Biol Psychiatry. 2021 04 15; 89(8):825-835.
Reus LM, Pasaniuc B, Posthuma D, Boltz T, International FTD-Genomics Consortium, Pijnenburg YAL, Ophoff RA. PMID: 33637304; PMCID: PMC8415425.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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The Joint-Brain Axis: Insights From Rheumatoid Arthritis on the Crosstalk Between Chronic Peripheral Inflammation and the Brain. Front Immunol. 2020; 11:612104.
Süß P, Rothe T, Hoffmann A, Schlachetzki JCM, Winkler J. PMID: 33362800; PMCID: PMC7758283.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Neuron. 2021 02 03; 109(3):448-460.e4.
Dewan R, Chia R, Ding J, Hickman RA, Stein TD, Abramzon Y, Ahmed S, Sabir MS, Portley MK, Tucci A, Ibáñez K, Shankaracharya FNU, Keagle P, Rossi G, Caroppo P, Tagliavini F, Waldo ML, Johansson PM, Nilsson CF, American Genome Center (TAGC), FALS Sequencing Consortium, Genomics England Research Consortium, International ALS/FTD Genomics Consortium (iAFGC), International FTD Genetics Consortium (IFGC), International LBD Genomics Consortium (iLBDGC), NYGC ALS Consortium, PROSPECT Consortium, Rowe JB, Benussi L, Binetti G, Ghidoni R, Jabbari E, Viollet C, Glass JD, Singleton AB, Silani V, Ross OA, Ryten M, Torkamani A, Tanaka T, Ferrucci L, Resnick SM, Pickering-Brown S, Brady CB, Kowal N, Hardy JA, Van Deerlin V, Vonsattel JP, Harms MB, Morris HR, Ferrari R, Landers JE, Chiò A, Gibbs JR, Dalgard CL, Scholz SW, Traynor BJ. PMID: 33242422; PMCID: PMC7864894.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Long-term course of anterior spinal cord herniation presenting with an upper motor neuron syndrome: case report illustrating diagnostic and therapeutic implications. BMC Neurol. 2020 Aug 29; 20(1):321.
Regensburger M, Schlachetzki JCM, Klekamp J, Doerfler A, Winkler J. PMID: 32861240; PMCID: PMC7455782.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis. Sci Rep. 2020 07 22; 10(1):12184.
Gao Y, Wang T, Yu X, International FTD-Genomics Consortium (IFGC), Zhao H, Zeng P. PMID: 32699404; PMCID: PMC7376149.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta Neuropathol. 2020 05; 139(5):959-962.
van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E, DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB), Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kawalia A, Dalmasso MC, Boada M, Zettl UK, van Schoor NM, Beekman M, Allen M, Masliah E, de Munain AL, Pantelyat A, Wszolek ZK, Ross OA, Dickson DW, Graff-Radford NR, Knopman D, Rademakers R, Lemstra AW, Pijnenburg YAL, Scheltens P, Gasser T, Chinnery PF, Hemmer B, Huisman MA, Troncoso J, Moreno F, Nohr EA, Sørensen TIA, Heutink P, Sánchez-Juan P, Posthuma D, GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Clarimón J, Christensen K, Ertekin-Taner N, Scholz SW, Ramirez A, Ruiz A, Slagboom E, van der Flier WM, Holstege H. PMID: 31955222; PMCID: PMC7181435.
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PubMed Mentions: Fields:
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Author Correction: A monocyte gene expression signature in the early clinical course of Parkinson's disease. Sci Rep. 2020 Apr 07; 10(1):6261.
Schlachetzki JCM, Prots I, Tao J, Chun HB, Saijo K, Gosselin D, Winner B, Glass CK, Winkler J. PMID: 32253373; PMCID: PMC7136204.
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PubMed Mentions:
1 Fields:
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Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System. Cell Rep. 2020 03 24; 30(12):4082-4095.e6.
Süß P, Hoffmann A, Rothe T, Ouyang Z, Baum W, Staszewski O, Schett G, Prinz M, Krönke G, Glass CK, Winkler J, Schlachetzki JCM. PMID: 32209470.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron. Exp Gerontol. 2020 05; 133:110876.
Schlachetzki JCM, Toda T, Mertens J. PMID: 32068088; PMCID: PMC7086016.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Microglia in Alzheimer's Disease. Curr Alzheimer Res. 2020; 17(1):29-43.
Süß P, Schlachetzki JCM. PMID: 32048973.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science. 2019 11 29; 366(6469):1134-1139.
Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. PMID: 31727856; PMCID: PMC7028213.
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PubMed Mentions:
246 Fields:
Translation:
HumansCells
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Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity. Immunity. 2019 10 15; 51(4):655-670.e8.
Sakai M, Troutman TD, Seidman JS, Ouyang Z, Spann NJ, Abe Y, Ego KM, Bruni CM, Deng Z, Schlachetzki JCM, Nott A, Bennett H, Chang J, Vu BT, Pasillas MP, Link VM, Texari L, Heinz S, Thompson BM, McDonald JG, Geissmann F, Glass CK. PMID: 31587991; PMCID: PMC6800814.
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PubMed Mentions:
124 Fields:
Translation:
AnimalsCells
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Transient naming deficits associated with insular lesions in a patient with encephalitis. Neurocase. 2019 12; 25(6):243-250.
Marxreiter F, Utz K, Schlachetzki JCM, Seifert F, Schmidt M, Doerfler A, Schwab S, Schenk T. PMID: 31532322.
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PubMed Mentions: Fields:
Translation:
Humans
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Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia. Sci Rep. 2019 07 26; 9(1):10854.
Bonham LW, Steele NZR, Karch CM, Broce I, Geier EG, Wen NL, Momeni P, Hardy J, Miller ZA, Gorno-Tempini ML, Hess CP, Lewis P, Miller BL, Seeley WW, Manzoni C, Desikan RS, Baranzini SE, Ferrari R, Yokoyama JS, International FTD-Genomics Consortium (IFGC). PMID: 31350420; PMCID: PMC6659677.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Oligodendroglial α-synucleinopathy-driven neuroinflammation in multiple system atrophy. Brain Pathol. 2019 05; 29(3):380-396.
Hoffmann A, Ettle B, Battis K, Reiprich S, Schlachetzki JCM, Masliah E, Wegner M, Kuhlmann T, Riemenschneider MJ, Winkler J. PMID: 30444295; PMCID: PMC6850330.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nat Med. 2019 01; 25(1):152-164.
Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ, International Frontotemporal Dementia Genomics Consortium, Grossman M, Van Deerlin VM, Trojanowski JQ, Lah JJ, Levey AI, Kondou S, Geschwind DH. PMID: 30510257; PMCID: PMC6602064.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Microbiome-microglia connections via the gut-brain axis. J Exp Med. 2019 01 07; 216(1):41-59.
Abdel-Haq R, Schlachetzki JCM, Glass CK, Mazmanian SK. PMID: 30385457; PMCID: PMC6314531.
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PubMed Mentions:
145 Fields:
Translation:
HumansAnimalsCells
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A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers. Brain. 2018 10 01; 141(10):2895-2907.
Zhang M, Ferrari R, Tartaglia MC, Keith J, Surace EI, Wolf U, Sato C, Grinberg M, Liang Y, Xi Z, Dupont K, McGoldrick P, Weichert A, McKeever PM, Schneider R, McCorkindale MD, Manzoni C, Rademakers R, Graff-Radford NR, Dickson DW, Parisi JE, Boeve BF, Petersen RC, Miller BL, Seeley WW, van Swieten JC, van Rooij J, Pijnenburg Y, van der Zee J, Van Broeckhoven C, Le Ber I, Van Deerlin V, Suh E, Rohrer JD, Mead S, Graff C, Öijerstedt L, Pickering-Brown S, Rollinson S, Rossi G, Tagliavini F, Brooks WS, Dobson-Stone C, Halliday GM, Hodges JR, Piguet O, Binetti G, Benussi L, Ghidoni R, Nacmias B, Sorbi S, Bruni AC, Galimberti D, Scarpini E, Rainero I, Rubino E, Clarimon J, Lleó A, Ruiz A, Hernández I, Pastor P, Diez-Fairen M, Borroni B, Pasquier F, Deramecourt V, Lebouvier T, Perneczky R, Diehl-Schmid J, Grafman J, Huey ED, Mayeux R, Nalls MA, Hernandez D, Singleton A, Momeni P, Zeng Z, Hardy J, Robertson J, Zinman L, Rogaeva E, International FTD-Genomics Consortium (IFGC). PMID: 30252044; PMCID: PMC6158742.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Sensor-based gait analysis of individualized improvement during apomorphine titration in Parkinson's disease. J Neurol. 2018 Nov; 265(11):2656-2665.
Marxreiter F, Gaßner H, Borozdina O, Barth J, Kohl Z, Schlachetzki JCM, Thun-Hohenstein C, Volc D, Eskofier BM, Winkler J, Klucken J. PMID: 30196324.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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A monocyte gene expression signature in the early clinical course of Parkinson's disease. Sci Rep. 2018 Jul 17; 8(1):10757.
Schlachetzki JCM, Prots I, Tao J, Chun HB, Saijo K, Gosselin D, Winner B, Glass CK, Winkler J. PMID: 30018301; PMCID: PMC6050266.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. Cell Rep. 2018 05 29; 23(9):2550-2558.
Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH. PMID: 29847787; PMCID: PMC6478017.
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PubMed Mentions:
50 Fields:
Translation:
HumansCells
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Author Correction: Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS. Sci Rep. 2018 May 14; 8(1):7789.
Taskesen E, Mishra A, van der Sluis S, Ferrari R, International FTD-Genomics Consortium, Veldink JH, van Es MA, Smit AB, Posthuma D, Pijnenburg Y. PMID: 29760392; PMCID: PMC5951859.
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PubMed Mentions:
2 Fields:
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CXCR4 involvement in neurodegenerative diseases. Transl Psychiatry. 2018 04 11; 8(1):73.
Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller BL, Andreassen OA, Dale AM, Barkovich AJ, Yokoyama JS, Desikan RS, International FTD-Genomics Consortium (IFGC), International Parkinson’s Disease Genetics Consortium (IPDGC), International Genomics of Alzheimer’s Project (IGAP). PMID: 29636460; PMCID: PMC5893558.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Med. 2018 01; 15(1):e1002487.
Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, International FTD-Genomics Consortium, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, Rabinovici GD, Rosen HJ, Schellenberg GD, Franke A, Karlsen TH, Veldink JH, Ferrari R, Yokoyama JS, Miller BL, Andreassen OA, Dale AM, Desikan RS, Sugrue LP. PMID: 29315334; PMCID: PMC5760014.
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PubMed Mentions:
73 Fields:
Translation:
Humans
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Gait and Cognition in Parkinson's Disease: Cognitive Impairment Is Inadequately Reflected by Gait Performance during Dual Task. Front Neurol. 2017; 8:550.
Gaßner H, Marxreiter F, Steib S, Kohl Z, Schlachetzki JCM, Adler W, Eskofier BM, Pfeifer K, Winkler J, Klucken J. PMID: 29123499; PMCID: PMC5662548.
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PubMed Mentions:
20
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Wearable sensors objectively measure gait parameters in Parkinson's disease. PLoS One. 2017; 12(10):e0183989.
Schlachetzki JCM, Barth J, Marxreiter F, Gossler J, Kohl Z, Reinfelder S, Gassner H, Aminian K, Eskofier BM, Winkler J, Klucken J. PMID: 29020012; PMCID: PMC5636070.
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PubMed Mentions:
106 Fields:
Translation:
Humans
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Increase of Reproductive Life Span Delays Age of Onset of Parkinson's Disease. Front Neurol. 2017; 8:397.
Frentzel D, Judanin G, Borozdina O, Klucken J, Winkler J, Schlachetzki JCM. PMID: 28871235; PMCID: PMC5566617.
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PubMed Mentions:
6
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Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS. Sci Rep. 2017 08 21; 7(1):8899.
Taskesen E, Mishra A, van der Sluis S, Ferrari R, International FTD-Genomics Consortium, Veldink JH, van Es MA, Smit AB, Posthuma D, Pijnenburg Y. PMID: 28827549; PMCID: PMC5567187.
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PubMed Mentions:
11 Fields:
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An environment-dependent transcriptional network specifies human microglia identity. Science. 2017 06 23; 356(6344).
Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK. PMID: 28546318; PMCID: PMC5858585.
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PubMed Mentions:
455 Fields:
Translation:
HumansAnimalsCells
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Gene-based association studies report genetic links for clinical subtypes of frontotemporal dementia. Brain. 2017 05 01; 140(5):1437-1446.
Mishra A, Ferrari R, Heutink P, Hardy J, Pijnenburg Y, Posthuma D, International FTD-Genomics Consortium. PMID: 28387812.
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PubMed Mentions:
29 Fields:
Translation:
Humans
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Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies. Neural Plast. 2017; 2017:3851262.
Kohl Z, Schlachetzki JC, Feldewerth J, Hornauer P, Münch M, Adame A, Riemenschneider MJ, Winkler J, Masliah E. PMID: 28409032; PMCID: PMC5376461.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Fingolimod effects in neuroinflammation: Regulation of astroglial glutamate transporters? PLoS One. 2017; 12(3):e0171552.
Lee DH, Seubert S, Huhn K, Brecht L, Rötger C, Waschbisch A, Schlachetzki J, Klausmeyer A, Melms A, Wiese S, Winkler J, Linker RA. PMID: 28273090; PMCID: PMC5342171.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry. 2017 02; 88(2):152-164.
Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB, International FTD-Genomics Consortium (IFGC), , International Parkinson's Disease Genomics Consortium (IPDGC), , International Genomics of Alzheimer's Project (IGAP), , Momeni P, Schellenberg GD, Dillon WP, Sugrue LP, Hess CP, Yokoyama JS, Bonham LW, Rabinovici GD, Miller BL, Andreassen OA, Dale AM, Hardy J, Desikan RS. PMID: 27899424; PMCID: PMC5237405.
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PubMed Mentions:
56 Fields:
Translation:
Humans
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Alpha-synuclein activates BV2 microglia dependent on its aggregation state. Biochem Biophys Res Commun. 2016 Oct 28; 479(4):881-886.
Hoffmann A, Ettle B, Bruno A, Kulinich A, Hoffmann AC, von Wittgenstein J, Winkler J, Xiang W, Schlachetzki JCM. PMID: 27666480.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Combined accelerometer and EMG analysis to differentiate essential tremor from Parkinson's disease. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:672-675.
Ghassemi NH, Marxreiter F, Pasluosta CF, Kugler P, Schlachetzki J, Schramm A, Eskofier BM, Klucken J. PMID: 28268417.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Paradoxical kinesia in Parkinson's disease revisited: Anticipation of temporal constraints is critical. Neuropsychologia. 2016 06; 86:38-44.
Distler M, Schlachetzki JC, Kohl Z, Winkler J, Schenk T. PMID: 27090103.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy. Acta Neuropathol. 2016 07; 132(1):59-75.
Ettle B, Kerman BE, Valera E, Gillmann C, Schlachetzki JC, Reiprich S, Büttner C, Ekici AB, Reis A, Wegner M, Bäuerle T, Riemenschneider MJ, Masliah E, Gage FH, Winkler J. PMID: 27059609; PMCID: PMC4912450.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Distinct Effects of Chronic Dopaminergic Stimulation on Hippocampal Neurogenesis and Striatal Doublecortin Expression in Adult Mice. Front Neurosci. 2016; 10:77.
Salvi R, Steigleder T, Schlachetzki JC, Waldmann E, Schwab S, Winner B, Winkler J, Kohl Z. PMID: 27013940; PMCID: PMC4786557.
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PubMed Mentions:
15
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Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein. J Neurosci Res. 2016 Jan; 94(1):62-73.
Schlachetzki JC, Grimm T, Schlachetzki Z, Ben Abdallah NM, Ettle B, Vöhringer P, Ferger B, Winner B, Nuber S, Winkler J. PMID: 26451750.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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From sweet to sweat: Hedonic olfactory range is impaired in Parkinson's disease. Parkinsonism Relat Disord. 2016 Jan; 22:9-14.
Mrochen A, Marxreiter F, Kohl Z, Schlachetzki J, Renner B, Schenk T, Winkler J, Klucken J. PMID: 26627940.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Hippocampal structure and function are maintained despite severe innate peripheral inflammation. Brain Behav Immun. 2015 Oct; 49:156-70.
Süß P, Kalinichenko L, Baum W, Reichel M, Kornhuber J, Loskarn S, Ettle B, Distler JH, Schett G, Winkler J, Müller CP, Schlachetzki JC. PMID: 26074461.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders? Mol Neurobiol. 2016 07; 53(5):3046-3062.
Ettle B, Schlachetzki JCM, Winkler J. PMID: 25966971; PMCID: PMC4902834.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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The innate immune system in Parkinson's disease: a novel target promoting endogenous neuroregeneration. Neural Regen Res. 2015 May; 10(5):704-6.
Schlachetzki JC, Winkler J. PMID: 26109939; PMCID: PMC4468756.
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PubMed Mentions:
9
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Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity. Mol Neurodegener. 2015 Mar 11; 10:8.
Xiang W, Menges S, Schlachetzki JC, Meixner H, Hoffmann AC, Schlötzer-Schrehardt U, Becker CM, Winkler J, Klucken J. PMID: 25886189; PMCID: PMC4365527.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells. Mol Cell Neurosci. 2014 Sep; 62:68-78.
Ettle B, Reiprich S, Deusser J, Schlachetzki JC, Xiang W, Prots I, Masliah E, Winner B, Wegner M, Winkler J. PMID: 25019582; PMCID: PMC4170075.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Frontotemporal dementia and its subtypes: a genome-wide association study. Lancet Neurol. 2014 Jul; 13(7):686-99.
Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JB, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, Hernández I, Ruiz A, Boada M, Borroni B, Padovani A, Cruchaga C, Cairns NJ, Benussi L, Binetti G, Ghidoni R, Forloni G, Galimberti D, Fenoglio C, Serpente M, Scarpini E, Clarimón J, Lleó A, Blesa R, Waldö ML, Nilsson K, Nilsson C, Mackenzie IR, Hsiung GY, Mann DM, Grafman J, Morris CM, Attems J, Griffiths TD, McKeith IG, Thomas AJ, Pietrini P, Huey ED, Wassermann EM, Baborie A, Jaros E, Tierney MC, Pastor P, Razquin C, Ortega-Cubero S, Alonso E, Perneczky R, Diehl-Schmid J, Alexopoulos P, Kurz A, Rainero I, Rubino E, Pinessi L, Rogaeva E, St George-Hyslop P, Rossi G, Tagliavini F, Giaccone G, Rowe JB, Schlachetzki JC, Uphill J, Collinge J, Mead S, Danek A, Van Deerlin VM, Grossman M, Trojanowski JQ, van der Zee J, Deschamps W, Van Langenhove T, Cruts M, Van Broeckhoven C, Cappa SF, Le Ber I, Hannequin D, Golfier V, Vercelletto M, Brice A, Nacmias B, Sorbi S, Bagnoli S, Piaceri I, Nielsen JE, Hjermind LE, Riemenschneider M, Mayhaus M, Ibach B, Gasparoni G, Pichler S, Gu W, Rossor MN, Fox NC, Warren JD, Spillantini MG, Morris HR, Rizzu P, Heutink P, Snowden JS, Rollinson S, Richardson A, Gerhard A, Bruni AC, Maletta R, Frangipane F, Cupidi C, Bernardi L, Anfossi M, Gallo M, Conidi ME, Smirne N, Rademakers R, Baker M, Dickson DW, Graff-Radford NR, Petersen RC, Knopman D, Josephs KA, Boeve BF, Parisi JE, Seeley WW, Miller BL, Karydas AM, Rosen H, van Swieten JC, Dopper EG, Seelaar H, Pijnenburg YA, Scheltens P, Logroscino G, Capozzo R, Novelli V, Puca AA, Franceschi M, Postiglione A, Milan G, Sorrentino P, Kristiansen M, Chiang HH, Graff C, Pasquier F, Rollin A, Deramecourt V, Lebert F, Kapogiannis D, Ferrucci L, Pickering-Brown S, Singleton AB, Hardy J, Momeni P. PMID: 24943344; PMCID: PMC4112126.
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PubMed Mentions:
149 Fields:
Translation:
Humans
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Intracerebroventricular administration of nerve growth factor induces gliogenesis in sensory ganglia, dorsal root, and within the dorsal root entry zone. Biomed Res Int. 2014; 2014:704259.
Schlachetzki JC, Pizzo DP, Morrissette DA, Winkler J. PMID: 24738070; PMCID: PMC3971563.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Increased tyrosine hydroxylase expression accompanied by glial changes within the non-lesioned hemisphere in the 6-hydroxydopamine model of Parkinson's disease. Restor Neurol Neurosci. 2014; 32(4):447-62.
Schlachetzki JC, Marxreiter F, Regensburger M, Kulinich A, Winner B, Winkler J. PMID: 24604006.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Granulocyte colony-stimulating factor does not promote neurogenesis after experimental intracerebral haemorrhage. Int J Stroke. 2014 Aug; 9(6):783-8.
Kallmünzer B, Tauchi M, Schlachetzki JC, Machold K, Schmidt A, Winkler J, Schwab S, Kollmar R. PMID: 24920160.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Unbiased and mobile gait analysis detects motor impairment in Parkinson's disease. PLoS One. 2013; 8(2):e56956.
Klucken J, Barth J, Kugler P, Schlachetzki J, Henze T, Marxreiter F, Kohl Z, Steidl R, Hornegger J, Eskofier B, Winkler J. PMID: 23431395; PMCID: PMC3576377.
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PubMed Mentions:
57 Fields:
Translation:
Humans
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Oxidative stress-induced posttranslational modifications of alpha-synuclein: specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity. Mol Cell Neurosci. 2013 May; 54:71-83.
Xiang W, Schlachetzki JC, Helling S, Bussmann JC, Berlinghof M, Schäffer TE, Marcus K, Winkler J, Klucken J, Becker CM. PMID: 23369945.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Studying neurodegenerative diseases in culture models. Braz J Psychiatry. 2013; 35 Suppl 2:S92-100.
Schlachetzki JC, Saliba SW, Oliveira AC. PMID: 24271231.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Automatic recognition of Parkinson's disease using surface electromyography during standardized gait tests. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:5781-4.
Kugler P, Jaremenko C, Schlachetzki J, Winkler J, Klucken J, Eskofier B. PMID: 24111052.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia. J Neuroinflammation. 2012 Jan 03; 9:2.
de Oliveira AC, Candelario-Jalil E, Langbein J, Wendeburg L, Bhatia HS, Schlachetzki JC, Biber K, Fiebich BL. PMID: 22214188; PMCID: PMC3283507.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Minocycline reduces prostaglandin E synthase expression and 8-isoprostane formation in LPS-activated primary rat microglia. Immunopharmacol Immunotoxicol. 2011 Sep; 33(3):576-80.
Silva Bastos LF, Pinheiro de Oliveira AC, Magnus Schlachetzki JC, Fiebich BL. PMID: 21226556.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Hand hygiene seems to be sufficient for prevention of MRSA transmission on a closed psychiatric ward. J Hosp Infect. 2010 Aug; 75(4):334-5.
Ebner W, Schlachetzki J, Schneider C, Dettenkofer M, Langosch JM. PMID: 20338668.
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PubMed Mentions: Fields:
Translation:
HumansCellsPHPublic Health
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Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia. J Neuroinflammation. 2010 Jan 11; 7:2.
Schlachetzki JC, Fiebich BL, Haake E, de Oliveira AC, Candelario-Jalil E, Heneka MT, Hüll M. PMID: 20064241; PMCID: PMC2819253.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Microglial activation in Alzheimer's disease. Curr Alzheimer Res. 2009 Dec; 6(6):554-63.
Schlachetzki JC, Hüll M. PMID: 19747160.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Frequency of progranulin mutations in a German cohort of 79 frontotemporal dementia patients. J Neurol. 2009 Dec; 256(12):2043-51.
Schlachetzki JC, Schmidtke K, Beckervordersandforth J, Borozdin W, Wilhelm C, Hüll M, Kohlhase J. PMID: 19618231.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Both systemic and local application of granulocyte-colony stimulating factor (G-CSF) is neuroprotective after retinal ganglion cell axotomy. BMC Neurosci. 2009 May 14; 10:49.
Frank T, Schlachetzki JC, Göricke B, Meuer K, Rohde G, Dietz GP, Bähr M, Schneider A, Weishaupt JH. PMID: 19442279; PMCID: PMC2691410.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Aripiprazole induced hypersexuality in a 24-year-old female patient with schizoaffective disorder? J Clin Psychopharmacol. 2008 Oct; 28(5):567-8.
Schlachetzki JC, Langosch JM. PMID: 18794655.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Hematopoietic cytokines--on the verge of conquering neurology. Curr Mol Med. 2007 Mar; 7(2):157-70.
Tönges L, Schlachetzki JC, Weishaupt JH, Bähr M. PMID: 17346168.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease. J Neurochem. 2006 May; 97(3):675-86.
Meuer K, Pitzer C, Teismann P, Krüger C, Göricke B, Laage R, Lingor P, Peters K, Schlachetzki JC, Kobayashi K, Dietz GP, Weber D, Ferger B, Schäbitz WR, Bach A, Schulz JB, Bähr M, Schneider A, Weishaupt JH. PMID: 16573658.
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PubMed Mentions:
51 Fields:
Translation:
AnimalsCells
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Varicella zoster virus cerebellitis in a 66-year-old patient without herpes zoster. Lancet. 2006 Jan 14; 367(9505):182.
Ratzka P, Schlachetzki JC, Bähr M, Nau R. PMID: 16413882.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells