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Lawrence Goldstein

Title(s)Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone858-534-9702
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    Collapse Overview
    The primary goals in the Goldstein lab are to unravel how molecular motors interact with, and control the behavior of, axonal vesicles, and to relate this understanding to the molecular basis of neuronal defects in Alzheimer's Disease (AD) and Niemann Pick type C disease.

    We are taking advantage of pluripotent stem cell lines that contain known mutations that cause hereditary Alzheimer's disease, as well as Niemann Pick Type C disease. This latter disease is of interest because it directly ties cholesterol trafficking and transport to what appears to be a pediatric form of Alzheimer type dementia.

    We are also using these cell lines and animal models to probe basic mechanisms of vesicle movement and sorting in neurons, and how such mechanisms inter-relate with disease development. In a related endeavor, we are probing how genetic variation predisposes to different neuronal phenotypes and disease by developing pluripotent stem cell lines carrying genomes of people who developed sporadic Alzheimer's disease or in one case carry susceptibility elements (from Craig Venter whose diploid genome is completely sequenced and which is known to harbor Alzheimer susceptibility variants).

    To study these problems, we have collaborated with BD biosciences to develop new quantitative methods for generating and purifying neurons made from human embryonic stem cells and induced pluripotent stem cells. We have also developed quantitative methods for evaluating AD phenotypes in these cells. Finally, building upon collaborative work with the Cleveland laboratory, we are developing a potential therapy for ALS (a.k.a. Lou Gehrig's disease) by using human embryonic stem cells to generate human astrocyte progenitors, which are being tested in animal models for safety and effectiveness. We hope that this investigation will lead to clinical trials in the coming years.

    Research Focus Areas:


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    Probing the molecular and cellular complexity of APP trafficking and its relationship to AD.
    NIH/NIA R56AG054013Sep 30, 2017 - Aug 31, 2018
    Role: Principal Investigator
    Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
    NIH/NIMH U19MH107367Jul 19, 2017 - Jun 30, 2020
    Role: Co-Investigator
    Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method
    NIH/NIGMS R44GM112442Sep 1, 2014 - Jun 30, 2017
    Role: Principal Investigator
    Elucidating AD genotype-phenotype relationships using genetics of human IPS cells
    NIH/NIA RF1AG048083Aug 15, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Testing cell autonomy of AD phenotypes using human IPS cells
    NIH/NINDS R21NS076869May 1, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Pluripotent stem cell models of sporadic Alzheimer's Disease
    NIH/NIA R21AG038849Sep 1, 2011 - Jun 30, 2013
    Role: Principal Investigator
    REGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTES
    NIH/NHLBI U01HL107442Jul 15, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Human Stem Cell Model of Niemann Pick Type C
    NIH/NINDS RC1NS068705Apr 15, 2010 - Mar 31, 2012
    Role: Principal Investigator
    Impairment of axonal transport by Amyloid precursor protein and amyloid Beta-prot
    NIH/NIA R01AG032180Sep 15, 2007 - Aug 31, 2012
    Role: Principal Investigator
    Genetic Analysis of Dendritic Targeting
    NIH/FIC R03TW005784Dec 14, 2001 - Nov 30, 2004
    Role: Principal Investigator
    Training Program in Basic and Clinical Genetics
    NIH/NIGMS T32GM008666Jul 1, 1998 - Jun 30, 2022
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH/NIA P50AG005131Apr 1, 1997 - Mar 31, 2019
    Role: Co-Investigator
    GENETIC AND IMMUNOLOGIC ANALYSIS OF MICROTUBULE PROTEINS
    NIH/NIGMS R01GM035252Aug 30, 1985 - Jul 31, 2007
    Role: Principal Investigator
    Administrative Core
    NIH/NIMH U19MH-01
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Amyloid-ß-independent regulators of tau pathology in Alzheimer disease. Nat Rev Neurosci. 2020 01; 21(1):21-35. van der Kant R, Goldstein LSB, Ossenkoppele R. PMID: 31780819.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells. Nat Genet. 2019 12; 51(12):1691-1701. Almenar-Queralt A, Merkurjev D, Kim HS, Navarro M, Ma Q, Chaves RS, Allegue C, Driscoll SP, Chen AG, Kohlnhofer B, Fong LK, Woodruff G, Mackintosh C, Bohaciakova D, Hruska-Plochan M, Tadokoro T, Young JE, El Hajj N, Dittrich M, Marsala M, Goldstein LSB, Garcia-Bassets I. PMID: 31740836.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-ß in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. 2019 03 07; 24(3):363-375.e9. van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB. PMID: 30686764.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    4. Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-ß clearance in human astrocytes. J Biol Chem. 2018 07 20; 293(29):11341-11357. Fong LK, Yang MM, Dos Santos Chaves R, Reyna SM, Langness VF, Woodruff G, Roberts EA, Young JE, Goldstein LSB. PMID: 29858247.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein. Stem Cell Reports. 2018 03 13; 10(3):1046-1058. Young JE, Fong LK, Frankowski H, Petsko GA, Small SA, Goldstein LSB. PMID: 29503090.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    6. High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 04 11; 8(4):1101-1111. D'Antonio M, Woodruff G, Nathanson JL, D'Antonio-Chronowska A, Arias A, Matsui H, Williams R, Herrera C, Reyna SM, Yeo GW, Goldstein LSB, Panopoulos AD, Frazer KA. PMID: 28410643.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    7. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. Stem Cell Reports. 2017 04 11; 8(4):1086-1100. Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MKR, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans SM, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein LSB, Izpisua Belmonte JC, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA. PMID: 28410642.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    8. Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations. Cell Rep. 2016 10 11; 17(3):759-773. Woodruff G, Reyna SM, Dunlap M, Van Der Kant R, Callender JA, Young JE, Roberts EA, Goldstein LS. PMID: 27732852.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    9. Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells. Cell Stem Cell. 2015 Apr 02; 16(4):373-85. Young JE, Boulanger-Weill J, Williams DA, Woodruff G, Buen F, Revilla AC, Herrera C, Israel MA, Yuan SH, Edland SD, Goldstein LS. PMID: 25772071.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    10. A ?-secretase inhibitor, but not a ?-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. PMID: 25710492.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    11. Cellular functions of the amyloid precursor protein from development to dementia. Dev Cell. 2015 Feb 23; 32(4):502-15. van der Kant R, Goldstein LS. PMID: 25710536.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    12. Probing the secrets of Alzheimer's disease using human-induced pluripotent stem cell technology. Neurotherapeutics. 2015 Jan; 12(1):121-5. Goldstein LS, Reyna S, Woodruff G. PMID: 25534395.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Effect of potent ?-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014 Dec; 71(12):1481-9. Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. PMID: 25285942.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    14. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Mol Biol Cell. 2015 Jan 15; 26(2):205-17. Niederst ED, Reyna SM, Goldstein LS. PMID: 25392299.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    15. Characterizing the composition of molecular motors on moving axonal cargo using "cargo mapping" analysis. J Vis Exp. 2014 Oct 30; (92):e52029. Neumann S, Campbell GE, Szpankowski L, Goldstein LS, Encalada SE. PMID: 25406537.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury. Neuron. 2014 Aug 20; 83(4):789-96. Lu P, Woodruff G, Wang Y, Graham L, Hunt M, Wu D, Boehle E, Ahmad R, Poplawski G, Brock J, Goldstein LS, Tuszynski MH. PMID: 25123310.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    17. UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. J Neurosci. 2014 Feb 26; 34(9):3320-39. Almenar-Queralt A, Falzone TL, Shen Z, Lillo C, Killian RL, Arreola AS, Niederst ED, Ng KS, Kim SN, Briggs SP, Williams DS, Goldstein LS. PMID: 24573290.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    18. Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function. J Cell Sci. 2014 Apr 01; 127(Pt 7):1537-49. Otero MG, Alloatti M, Cromberg LE, Almenar-Queralt A, Encalada SE, Pozo Devoto VM, Bruno L, Goldstein LS, Falzone TL. PMID: 24522182.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    19. Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration. Annu Rev Biophys. 2014; 43:141-69. Encalada SE, Goldstein LS. PMID: 24702007.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    20. The presenilin-1 ?E9 mutation results in reduced ?-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. Cell Rep. 2013 Nov 27; 5(4):974-85. Woodruff G, Young JE, Martinez FJ, Buen F, Gore A, Kinaga J, Li Z, Yuan SH, Zhang K, Goldstein LS. PMID: 24239350.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    21. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013 Dec 06; 288(49):35222-36. Almenar-Queralt A, Kim SN, Benner C, Herrera CM, Kang DE, Garcia-Bassets I, Goldstein LS. PMID: 24145027.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila. PLoS One. 2013; 8(6):e68324. Duncan JE, Lytle NK, Zuniga A, Goldstein LS. PMID: 23840848.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    23. Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. Hum Mol Genet. 2013 Oct 01; 22(19):3828-43. Gunawardena S, Yang G, Goldstein LS. PMID: 23710041.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    24. Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. EMBO J. 2013 May 29; 32(11):1489-95. Bianco P, Barker R, Brüstle O, Cattaneo E, Clevers H, Daley GQ, De Luca M, Goldstein L, Lindvall O, Mummery C, Robey PG, Sattler de Sousa E Brito C, Smith A. PMID: 23644381.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    25. Position statement on the provision and procurement of human eggs for stem cell research. Cell Stem Cell. 2013 Mar 07; 12(3):285-91. Haimes E, Skene L, Ballantyne AJ, Caulfield T, Goldstein LS, Hyun I, Kimmelman J, Robert JS, Roxland BE, Scott CT, Solbakk JH, Sugarman J, Taylor PL, Testa G. PMID: 23472870.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Using human-induced pluripotent stem cells to model monogenic metabolic disorders of the liver. Semin Liver Dis. 2012 Nov; 32(4):298-306. Ordonez MP, Goldstein LS. PMID: 23397530.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein. Traffic. 2013 Mar; 14(3):295-308. Weaver C, Leidel C, Szpankowski L, Farley NM, Shubeita GT, Goldstein LS. PMID: 23279138.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    28. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013 Mar 07; 12(3):316-28. Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH. PMID: 23333150.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    29. ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):1041-6. Jiang Q, Crews LA, Barrett CL, Chun HJ, Court AC, Isquith JM, Zipeto MA, Goff DJ, Minden M, Sadarangani A, Rusert JM, Dao KH, Morris SR, Goldstein LS, Marra MA, Frazer KA, Jamieson CH. PMID: 23275297.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    30. New frontiers in human cell biology and medicine: can pluripotent stem cells deliver? J Cell Biol. 2012 Nov 12; 199(4):577-81. Goldstein LS. PMID: 23148231.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    31. US election: Know your representatives. Nature. 2012 Sep 27; 489(7417):494-5. Goldstein L. PMID: 23018948.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    32. An October call to arms: we are research! Mol Biol Cell. 2012 Sep; 23(17):3279-80. Goldstein LS. PMID: 22936697.
      View in: PubMed   Mentions: 1     Fields:    
    33. Alzheimer's disease in a dish: promises and challenges of human stem cell models. Hum Mol Genet. 2012 Oct 15; 21(R1):R82-9. Young JE, Goldstein LS. PMID: 22865875.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    34. Enhanced ß-secretase processing alters APP axonal transport and leads to axonal defects. Hum Mol Genet. 2012 Nov 01; 21(21):4587-601. Rodrigues EM, Weissmiller AM, Goldstein LS. PMID: 22843498.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    35. Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8582-7. Szpankowski L, Encalada SE, Goldstein LS. PMID: 22582169.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    36. Axonal transport and neurodegenerative disease: can we see the elephant? Prog Neurobiol. 2012 Dec; 99(3):186-90. Goldstein LS. PMID: 22484448.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    37. Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Hum Mol Genet. 2012 Jun 15; 21(12):2651-62. Ordonez MP, Roberts EA, Kidwell CU, Yuan SH, Plaisted WC, Goldstein LS. PMID: 22437840.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    38. Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. Mol Biol Cell. 2012 May; 23(9):1700-14. Reis GF, Yang G, Szpankowski L, Weaver C, Shah SB, Robinson JT, Hays TS, Danuser G, Goldstein LS. PMID: 22398725.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    39. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25; 482(7384):216-20. Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. PMID: 22278060.
      View in: PubMed   Mentions: 342     Fields:    Translation:HumansCells
    40. Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PLoS One. 2012; 7(1):e29755. Killian RL, Flippin JD, Herrera CM, Almenar-Queralt A, Goldstein LS. PMID: 22272245.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    41. In the trenches: lessons for scientists from California's Proposition 71 campaign. Mol Biol Cell. 2011 Nov; 22(21):3943-4. Goldstein LS. PMID: 22039069.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds. Tissue Eng Part A. 2011 Nov; 17(21-22):2583-92. DeQuach JA, Yuan SH, Goldstein LS, Christman KL. PMID: 21883047.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    43. A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. Mol Biol Cell. 2011 Nov; 22(21):4038-46. Henthorn KS, Roux MS, Herrera C, Goldstein LS. PMID: 21880894.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    44. Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges. Genome Med. 2011 Jul 27; 3(7):49. Israel MA, Goldstein LS. PMID: 21867573.
      View in: PubMed   Mentions: 8     Fields:    
    45. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar 03; 471(7336):63-7. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. PMID: 21368825.
      View in: PubMed   Mentions: 454     Fields:    Translation:HumansCells
    46. Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One. 2011 Mar 02; 6(3):e17540. Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein LS, Carson CT. PMID: 21407814.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    47. Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Cell. 2011 Feb 18; 144(4):551-65. Encalada SE, Szpankowski L, Xia CH, Goldstein LS. PMID: 21335237.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    48. Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3005-10. Kim JE, O'Sullivan ML, Sanchez CA, Hwang M, Israel MA, Brennand K, Deerinck TJ, Goldstein LS, Gage FH, Ellisman MH, Ghosh A. PMID: 21278334.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    49. Unconventional allies: interdisciplinary approaches to science policy and funding. Trends Cell Biol. 2010 Dec; 20(12):695-8. Goldstein LS. PMID: 21106464.
      View in: PubMed   Mentions: 1     Fields:    
    50. Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies. Hum Mol Genet. 2010 Nov 15; 19(22):4399-408. Falzone TL, Gunawardena S, McCleary D, Reis GF, Goldstein LS. PMID: 20817925.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    51. Patients beware: commercialized stem cell treatments on the web. Cell Stem Cell. 2010 Jul 02; 7(1):43-9. Taylor PL, Barker RA, Blume KG, Cattaneo E, Colman A, Deng H, Edgar H, Fox IJ, Gerstle C, Goldstein LS, High KA, Lyall A, Parkman R, Pitossi FJ, Prentice ED, Rooke HM, Sipp DA, Srivastava A, Stayn S, Steinberg GK, Wagers AJ, Weissman IL. PMID: 20621049.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    52. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010 Jun 01; 24(11):1106-18. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan KL. PMID: 20516196.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansAnimalsCells
    53. Why scientific details are important when novel technologies encounter law, politics, and ethics. J Law Med Ethics. 2010; 38(2):204-11. Goldstein L. PMID: 20579243.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    54. Sunday driver interacts with two distinct classes of axonal organelles. J Biol Chem. 2009 Dec 11; 284(50):34628-39. Abe N, Almenar-Queralt A, Lillo C, Shen Z, Lozach J, Briggs SP, Williams DS, Goldstein LS, Cavalli V. PMID: 19801628.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    55. Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiol Dis. 2009 Oct; 36(1):11-25. Shah SB, Nolan R, Davis E, Stokin GB, Niesman I, Canto I, Glabe C, Goldstein LS. PMID: 19497367.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    56. Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. J Neurosci. 2009 May 06; 29(18):5758-67. Falzone TL, Stokin GB, Lillo C, Rodrigues EM, Westerman EL, Williams DS, Goldstein LS. PMID: 19420244.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    57. Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J Neurosci. 2008 Dec 10; 28(50):13662-72. Her LS, Goldstein LS. PMID: 19074039.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    58. Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Hum Mol Genet. 2008 Nov 15; 17(22):3474-86. Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS. PMID: 18694898.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    59. Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7594-9. Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein LS. PMID: 18492803.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    60. Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment. Mol Biol Cell. 2007 Jun; 18(6):2081-9. Haghnia M, Cavalli V, Shah SB, Schimmelpfeng K, Brusch R, Yang G, Herrera C, Pilling A, Goldstein LS. PMID: 17360970.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    61. Ethics. The ISSCR guidelines for human embryonic stem cell research. Science. 2007 Feb 02; 315(5812):603-4. Daley GQ, Ahrlund Richter L, Auerbach JM, Benvenisty N, Charo RA, Chen G, Deng HK, Goldstein LS, Hudson KL, Hyun I, Junn SC, Love J, Lee EH, McLaren A, Mummery CL, Nakatsuji N, Racowsky C, Rooke H, Rossant J, Schöler HR, Solbakk JH, Taylor P, Trounson AO, Weissman IL, Wilmut I, Yu J, Zoloth L. PMID: 17272706.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    62. Analysis of kinesin-2 function in photoreceptor cells using synchronous Cre-loxP knockout of Kif3a with RHO-Cre. Invest Ophthalmol Vis Sci. 2006 Nov; 47(11):5039-46. Jimeno D, Feiner L, Lillo C, Teofilo K, Goldstein LS, Pierce EA, Williams DS. PMID: 17065525.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    63. The genetics of axonal transport and axonal transport disorders. PLoS Genet. 2006 Sep 29; 2(9):e124. Duncan JE, Goldstein LS. PMID: 17009871.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    64. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42. Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC. PMID: 16815330.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    65. Linking molecular motors to Alzheimer's disease. J Physiol Paris. 2006 Mar-May; 99(2-3):193-200. Stokin GB, Goldstein LS. PMID: 16459060.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    66. Axonal transport and Alzheimer's disease. Annu Rev Biochem. 2006; 75:607-27. Stokin GB, Goldstein LS. PMID: 16756504.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    67. Kinesin-2 and photoreceptor cell death: requirement of motor subunits. Exp Eye Res. 2006 Feb; 82(2):351-3. Jimeno D, Lillo C, Roberts EA, Goldstein LS, Williams DS. PMID: 16337628.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    68. Sunday Driver links axonal transport to damage signaling. J Cell Biol. 2005 Feb 28; 168(5):775-87. Cavalli V, Kujala P, Klumperman J, Goldstein LS. PMID: 15738268.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    69. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005 Feb 25; 307(5713):1282-8. Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LS. PMID: 15731448.
      View in: PubMed   Mentions: 355     Fields:    Translation:HumansAnimalsCells
    70. Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways. Arch Neurol. 2005 Jan; 62(1):46-51. Gunawardena S, Goldstein LS. PMID: 15642849.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    71. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. PMID: 15479732.
      View in: PubMed   Mentions: 223     Fields:    Translation:HumansAnimals
    72. Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Curr Opin Cell Biol. 2004 Aug; 16(4):443-50. Guzik BW, Goldstein LS. PMID: 15261678.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    73. Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. J Neurobiol. 2004 Feb 05; 58(2):258-71. Gunawardena S, Goldstein LS. PMID: 14704957.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    74. Do disorders of movement cause movement disorders and dementia? Neuron. 2003 Oct 09; 40(2):415-25. Goldstein LS. PMID: 14556718.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    75. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science. 2003 Oct 03; 302(5642):113-7. Clement AM, Nguyen MD, Roberts EA, Garcia ML, Boillée S, Rule M, McMahon AP, Doucette W, Siwek D, Ferrante RJ, Brown RH, Julien JP, Goldstein LS, Cleveland DW. PMID: 14526083.
      View in: PubMed   Mentions: 294     Fields:    Translation:HumansAnimalsCells
    76. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron. 2003 Sep 25; 40(1):25-40. Gunawardena S, Her LS, Brusch RG, Laymon RA, Niesman IR, Gordesky-Gold B, Sintasath L, Bonini NM, Goldstein LS. PMID: 14527431.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimals
    77. Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol. 2003 Apr 14; 161(1):55-66. Xia CH, Roberts EA, Her LS, Liu X, Williams DS, Cleveland DW, Goldstein LS. PMID: 12682084.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    78. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5286-91. Lin F, Hiesberger T, Cordes K, Sinclair AM, Goldstein LS, Somlo S, Igarashi P. PMID: 12672950.
      View in: PubMed   Mentions: 211     Fields:    Translation:AnimalsCells
    79. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell. 2003 Apr; 4(4):521-33. Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. PMID: 12689591.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    80. Loss of heterozygosity analysis of mouse pulmonary adenomas induced by coal tar. Environ Mol Mutagen. 2003; 41(4):300-8. Benavides F, Conti CJ, LaCava M, Flores M, Glasscock E, Sternik G, Gimenez-Conti IB, Johnston DA, Dunsford HA, Goldstein LS, Rodriguez LV. PMID: 12717785.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    81. A genetic screen for suppressors and enhancers of the Drosophila cdk1-cyclin B identifies maternal factors that regulate microtubule and microfilament stability. Genetics. 2002 Nov; 162(3):1179-95. Ji JY, Haghnia M, Trusty C, Goldstein LS, Schubiger G. PMID: 12454065.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    82. Principles of cargo attachment to cytoplasmic motor proteins. Curr Opin Cell Biol. 2002 Feb; 14(1):63-8. Kamal A, Goldstein LS. PMID: 11792546.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    83. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001 Dec 06; 414(6864):643-8. Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. PMID: 11740561.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    84. Molecular motors: from one motor many tails to one motor many tales. Trends Cell Biol. 2001 Dec; 11(12):477-82. Goldstein LS. PMID: 11719052.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    85. Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron. 2001 Nov 08; 32(3):389-401. Gunawardena S, Goldstein LS. PMID: 11709151.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    86. Polarized fluorescence microscopy of individual and many kinesin motors bound to axonemal microtubules. Biophys J. 2001 Nov; 81(5):2851-63. Peterman EJ, Sosa H, Goldstein LS, Moerner WE. PMID: 11606296.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    87. Linkers, packages and pathways: new concepts in axonal transport. Curr Opin Neurobiol. 2001 Oct; 11(5):550-7. Almenar-Queralt A, Goldstein LS. PMID: 11595487.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    88. Functional analysis of mouse kinesin motor Kif3C. Mol Cell Biol. 2001 Aug; 21(16):5306-11. Yang Z, Roberts EA, Goldstein LS. PMID: 11463814.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    89. Kinesin molecular motors: transport pathways, receptors, and human disease. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):6999-7003. Goldstein LS. PMID: 11416178.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    90. ADP-induced rocking of the kinesin motor domain revealed by single-molecule fluorescence polarization microscopy. Nat Struct Biol. 2001 Jun; 8(6):540-4. Sosa H, Peterman EJ, Moerner WE, Goldstein LS. PMID: 11373624.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    91. Functional analysis of mouse C-terminal kinesin motor KifC2. Mol Cell Biol. 2001 Apr; 21(7):2463-6. Yang Z, Roberts EA, Goldstein LS. PMID: 11259594.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    92. Transduction. When worlds collide--trafficking in JNK. Science. 2001 Mar 16; 291(5511):2102-3. Goldstein LS. PMID: 11256408.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    93. Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3. Mol Cell Biol. 2001 Feb; 21(3):765-70. Yang Z, Xia Ch, Roberts EA, Bush K, Nigam SK, Goldstein LS. PMID: 11154264.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    94. Cytoskeleton. Curr Opin Cell Biol. 2001 Feb; 13(1):17-8. Goldstein LS, Theriot JA. PMID: 11163128.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    95. Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. Cell. 2000 Nov 10; 103(4):583-94. Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS. PMID: 11106729.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    96. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron. 2000 Nov; 28(2):449-59. Kamal A, Stokin GB, Yang Z, Xia CH, Goldstein LS. PMID: 11144355.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    97. Connecting vesicle transport to the cytoskeleton. Curr Opin Cell Biol. 2000 Aug; 12(4):503-8. Kamal A, Goldstein LS. PMID: 10873823.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    98. Flying through the drosophila cytoskeletal genome. J Cell Biol. 2000 Jul 24; 150(2):F63-8. Goldstein LS, Gunawardena S. PMID: 10908588.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    99. Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Cell. 2000 Jul 21; 102(2):175-87. Marszalek JR, Liu X, Roberts EA, Chui D, Marth JD, Williams DS, Goldstein LS. PMID: 10943838.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    100. CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. J Cell Biol. 2000 Jul 10; 150(1):1-11. Yucel JK, Marszalek JD, McIntosh JR, Goldstein LS, Cleveland DW, Philp AV. PMID: 10893249.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    101. Drosophila beta spectrin functions independently of alpha spectrin to polarize the Na,K ATPase in epithelial cells. J Cell Biol. 2000 May 01; 149(3):647-56. Dubreuil RR, Wang P, Dahl S, Lee J, Goldstein LS. PMID: 10791978.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    102. Does motor protein intelligence contribute to neuronal polarity? Neuron. 2000 May; 26(2):281-2. Shah JV, Goldstein LS. PMID: 10839344.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    103. Comparative genomics of the eukaryotes. Science. 2000 Mar 24; 287(5461):2204-15. Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, Birney E, Boguski MS, Brody T, Brokstein P, Celniker SE, Chervitz SA, Coates D, Cravchik A, Gabrielian A, Galle RF, Gelbart WM, George RA, Goldstein LS, Gong F, Guan P, Harris NL, Hay BA, Hoskins RA, Li J, Li Z, Hynes RO, Jones SJ, Kuehl PM, Lemaitre B, Littleton JT, Morrison DK, Mungall C, O'Farrell PH, Pickeral OK, Shue C, Vosshall LB, Zhang J, Zhao Q, Zheng XH, Lewis S. PMID: 10731134.
      View in: PubMed   Mentions: 434     Fields:    Translation:HumansAnimalsCells
    104. Understanding the functions of kinesin-II. Biochim Biophys Acta. 2000 Mar 17; 1496(1):142-50. Marszalek JR, Goldstein LS. PMID: 10722883.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    105. Microtubule-based transport systems in neurons: the roles of kinesins and dyneins. Annu Rev Neurosci. 2000; 23:39-71. Goldstein LS, Yang Z. PMID: 10845058.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    106. Cloning and expression of kinesins from the thermophilic fungus Thermomyces lanuginosus. Protein Sci. 1999 Dec; 8(12):2705-10. Sakowicz R, Farlow S, Goldstein LS. PMID: 10631986.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    107. Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila. J Cell Biol. 1999 Nov 01; 147(3):507-18. Ray K, Perez SE, Yang Z, Xu J, Ritchings BW, Steller H, Goldstein LS. PMID: 10545496.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    108. Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. J Cell Biol. 1999 Sep 20; 146(6):1277-88. Rahman A, Kamal A, Roberts EA, Goldstein LS. PMID: 10491391.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    109. Adociasulfates 1-6, Inhibitors of Kinesin Motor Proteins from the Sponge Haliclona (aka Adocia) sp. J Org Chem. 1999 Jul 23; 64(15):5565-5570. Blackburn CL, Hopmann C, Sakowicz R, Berdelis MS, Goldstein LS, Faulkner DJ. PMID: 11674622.
      View in: PubMed   Mentions: 6     Fields:    
    110. Drosophila roadblock and Chlamydomonas LC7: a conserved family of dynein-associated proteins involved in axonal transport, flagellar motility, and mitosis. J Cell Biol. 1999 Jul 12; 146(1):165-80. Bowman AB, Patel-King RS, Benashski SE, McCaffery JM, Goldstein LS, King SM. PMID: 10402468.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    111. Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B. J Cell Biol. 1999 May 03; 145(3):469-79. Marszalek JR, Weiner JA, Farlow SJ, Chun J, Goldstein LS. PMID: 10225949.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    112. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):5043-8. Marszalek JR, Ruiz-Lozano P, Roberts E, Chien KR, Goldstein LS. PMID: 10220415.
      View in: PubMed   Mentions: 178     Fields:    Translation:AnimalsCells
    113. The road less traveled: emerging principles of kinesin motor utilization. Annu Rev Cell Dev Biol. 1999; 15:141-83. Goldstein LS, Philp AV. PMID: 10611960.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    114. Chromosomal localization reveals three kinesin heavy chain genes in mouse. Genomics. 1998 Sep 01; 52(2):209-13. Xia Ch, Rahman A, Yang Z, Goldstein LS. PMID: 9782088.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    115. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. J Biol Chem. 1998 Jun 19; 273(25):15395-403. Rahman A, Friedman DS, Goldstein LS. PMID: 9624122.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    116. Kinesin light chains are essential for axonal transport in Drosophila. J Cell Biol. 1998 Apr 20; 141(2):443-54. Gindhart JG, Desai CJ, Beushausen S, Zinn K, Goldstein LS. PMID: 9548722.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    117. A marine natural product inhibitor of kinesin motors. Science. 1998 Apr 10; 280(5361):292-5. Sakowicz R, Berdelis MS, Ray K, Blackburn CL, Hopmann C, Faulkner DJ, Goldstein LS. PMID: 9535660.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    118. Cruising along microtubule highways: how membranes move through the secretory pathway. J Cell Biol. 1998 Mar 23; 140(6):1277-80. Bloom GS, Goldstein LS. PMID: 9508761.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    119. Characterization of the KIF3C neural kinesin-like motor from mouse. Mol Biol Cell. 1998 Feb; 9(2):249-61. Yang Z, Goldstein LS. PMID: 9450952.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    120. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Cell. 1997 Oct 31; 91(3):357-66. Wood KW, Sakowicz R, Goldstein LS, Cleveland DW. PMID: 9363944.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    121. Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse. Genomics. 1997 Oct 01; 45(1):123-31. Yang Z, Hanlon DW, Marszalek JR, Goldstein LS. PMID: 9339368.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    122. Probing the kinesin-microtubule interaction. J Biol Chem. 1997 Apr 04; 272(14):9481-8. Tucker C, Goldstein LS. PMID: 9083088.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    123. Mitochondrial association of a plus end-directed microtubule motor expressed during mitosis in Drosophila. J Cell Biol. 1997 Mar 10; 136(5):1081-90. Pereira AJ, Dalby B, Stewart RJ, Doxsey SJ, Goldstein LS. PMID: 9060472.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    124. Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. Neuron. 1997 Mar; 18(3):439-51. Hanlon DW, Yang Z, Goldstein LS. PMID: 9115737.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    125. alpha-Spectrin is required for ovarian follicle monolayer integrity in Drosophila melanogaster. Development. 1997 Jan; 124(2):353-62. Lee JK, Brandin E, Branton D, Goldstein LS. PMID: 9053311.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    126. Armadillo repeats in the SpKAP115 subunit of kinesin-II. Trends Cell Biol. 1996 Nov; 6(11):415-6. Gindhart JG, Goldstein LS. PMID: 15157510.
      View in: PubMed   Mentions: 10     Fields:    
    127. Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein. J Cell Biol. 1996 Jul; 134(2):455-64. Matthies HJ, McDonald HB, Goldstein LS, Theurkauf WE. PMID: 8707829.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    128. The muscle in kinesin. Nat Struct Biol. 1996 May; 3(5):404-7. Sakowicz R, Goldstein LS. PMID: 8612068.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    129. Going mobile: microtubule motors and chromosome segregation. Proc Natl Acad Sci U S A. 1996 Mar 05; 93(5):1735-42. Barton NR, Goldstein LS. PMID: 8700828.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    130. Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell. 1996 Feb 23; 84(4):599-609. Desai CJ, Gindhart JG, Goldstein LS, Zinn K. PMID: 8598046.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    131. Tetratrico peptide repeats are present in the kinesin light chain. Trends Biochem Sci. 1996 Feb; 21(2):52-3. Gindhart JG, Goldstein LS. PMID: 8851660.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    132. Motor activity and mitotic spindle localization of the Drosophila kinesin-like protein KLP61F. Mol Biol Cell. 1995 Nov; 6(11):1563-74. Barton NR, Pereira AJ, Goldstein LS. PMID: 8589456.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    133. DNA binding and meiotic chromosomal localization of the Drosophila nod kinesin-like protein. Cell. 1995 Apr 07; 81(1):129-38. Afshar K, Barton NR, Hawley RS, Goldstein LS. PMID: 7720068.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    134. Structural features involved in force generation in the kinesin superfamily. Biophys J. 1995 Apr; 68(4 Suppl):260S-265S; discussion 265S-266S. Goldstein LS. PMID: 7787087.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    135. An inverse PCR screen for the detection of P element insertions in cloned genomic intervals in Drosophila melanogaster. Genetics. 1995 Feb; 139(2):757-66. Dalby B, Pereira AJ, Goldstein LS. PMID: 7713430.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    136. Drosophila development requires spectrin network formation. J Cell Biol. 1995 Jan; 128(1-2):71-9. Deng H, Lee JK, Goldstein LS, Branton D. PMID: 7822424.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    137. Characterization of the KLP68D kinesin-like protein in Drosophila: possible roles in axonal transport. J Cell Biol. 1994 Nov; 127(4):1041-8. Pesavento PA, Stewart RJ, Goldstein LS. PMID: 7525600.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    138. Sources of information about the fly: where to look it up. Methods Cell Biol. 1994; 44:3-12. Goldstein LS. PMID: 7707959.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    139. Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster. J Cell Biol. 1993 Dec; 123(6 Pt 2):1797-809. Lee JK, Coyne RS, Dubreuil RR, Goldstein LS, Branton D. PMID: 8276898.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    140. The kinesin-like protein KLP61F is essential for mitosis in Drosophila. J Cell Biol. 1993 Nov; 123(3):665-79. Heck MM, Pereira A, Pesavento P, Yannoni Y, Spradling AC, Goldstein LS. PMID: 8227131.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    141. The Drosophila kinesin light chain. Primary structure and interaction with kinesin heavy chain. J Biol Chem. 1993 Jun 25; 268(18):13657-66. Gauger AK, Goldstein LS. PMID: 8514798.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    142. Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5209-13. Stewart RJ, Thaler JP, Goldstein LS. PMID: 8506368.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    143. With apologies to scheherazade: tails of 1001 kinesin motors. Annu Rev Genet. 1993; 27:319-51. Goldstein LS. PMID: 8122906.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    144. Functional redundancy in mitotic force generation. J Cell Biol. 1993 Jan; 120(1):1-3. Goldstein LS. PMID: 8416980.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    145. Cell biology. New cytoskeletal liaisons. Nature. 1992 Sep 17; 359(6392):193-4. Goldstein LS, Vale RD. PMID: 1388245.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    146. Evidence that the stalk of Drosophila kinesin heavy chain is an alpha-helical coiled coil. J Cell Biol. 1992 Feb; 116(4):957-65. de Cuevas M, Tao T, Goldstein LS. PMID: 1734025.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    147. Genetic analysis of a Drosophila microtubule-associated protein. J Cell Biol. 1992 Jan; 116(2):377-83. Pereira A, Doshen J, Tanaka E, Goldstein LS. PMID: 1309812.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    148. Identification and partial characterization of six members of the kinesin superfamily in Drosophila. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8470-4. Stewart RJ, Pesavento PA, Woerpel DN, Goldstein LS. PMID: 1924306.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    149. The kinesin superfamily: tails of functional redundancy. Trends Cell Biol. 1991 Oct; 1(4):93-8. Goldstein LS. PMID: 14731795.
      View in: PubMed   Mentions: 41     Fields:    
    150. Motor proteins. A brave new world for dynein. Nature. 1991 Aug 15; 352(6336):569-70. Goldstein LS, Vale RD. PMID: 1830924.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    151. Structure, calmodulin-binding, and calcium-binding properties of recombinant alpha spectrin polypeptides. J Biol Chem. 1991 Apr 15; 266(11):7189-93. Dubreuil RR, Brandin E, Reisberg JH, Goldstein LS, Branton D. PMID: 2016322.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    152. Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis. Cell. 1991 Mar 22; 64(6):1093-102. Saxton WM, Hicks J, Goldstein LS, Raff EC. PMID: 1825937.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    153. The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor. Cell. 1990 Dec 21; 63(6):1159-65. McDonald HB, Stewart RJ, Goldstein LS. PMID: 2261638.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    154. Analysis of the primary sequence and microtubule-binding region of the Drosophila 205K MAP. J Cell Biol. 1990 Dec; 111(6 Pt 1):2563-72. Irminger-Finger I, Laymon RA, Goldstein LS. PMID: 1703540.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    155. Bead movement by single kinesin molecules studied with optical tweezers. Nature. 1990 Nov 22; 348(6299):348-52. Block SM, Goldstein LS, Schnapp BJ. PMID: 2174512.
      View in: PubMed   Mentions: 231     Fields:    Translation:Cells
    156. A kinesin-like protein required for distributive chromosome segregation in Drosophila. Cell. 1990 Sep 21; 62(6):1053-62. Zhang P, Knowles BA, Goldstein LS, Hawley RS. PMID: 2144792.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    157. Evidence that the head of kinesin is sufficient for force generation and motility in vitro. Science. 1990 Jul 06; 249(4964):42-7. Yang JT, Saxton WM, Stewart RJ, Raff EC, Goldstein LS. PMID: 2142332.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    158. Identification and characterization of a gene encoding a kinesin-like protein in Drosophila. Cell. 1990 Jun 15; 61(6):991-1000. McDonald HB, Goldstein LS. PMID: 2140958.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    159. One motor, many tails: an expanding repertoire of force-generating enzymes. Cell. 1990 Mar 23; 60(6):883-5. Vale RD, Goldstein LS. PMID: 2138513.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    160. The conditional inhibition of gene expression in cultured Drosophila cells by antisense RNA. Nucleic Acids Res. 1989 Dec 11; 17(23):9761-82. Bunch TA, Goldstein LS. PMID: 2481266.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    161. The complete sequence of Drosophila alpha-spectrin: conservation of structural domains between alpha-spectrins and alpha-actinin. J Cell Biol. 1989 Nov; 109(5):2197-205. Dubreuil RR, Byers TJ, Sillman AL, Bar-Zvi D, Goldstein LS, Branton D. PMID: 2808524.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    162. Sequence similarity of the amino-terminal domain of Drosophila beta spectrin to alpha actinin and dystrophin. J Cell Biol. 1989 Oct; 109(4 Pt 1):1633-41. Byers TJ, Husain-Chishti A, Dubreuil RR, Branton D, Goldstein LS. PMID: 2677025.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    163. Identification of globular mechanochemical heads of kinesin. Nature. 1989 Mar 23; 338(6213):355-7. Scholey JM, Heuser J, Yang JT, Goldstein LS. PMID: 2493586.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    164. A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analyses. Cell. 1989 Mar 10; 56(5):879-89. Yang JT, Laymon RA, Goldstein LS. PMID: 2522352.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    165. Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family. EMBO J. 1989 Mar; 8(3):913-22. Kiehart DP, Lutz MS, Chan D, Ketchum AS, Laymon RA, Nguyen B, Goldstein LS. PMID: 2498088.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    166. Isolation and characterization of the gene encoding the heavy chain of Drosophila kinesin. Proc Natl Acad Sci U S A. 1988 Mar; 85(6):1864-8. Yang JT, Saxton WM, Goldstein LS. PMID: 3126498.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    167. Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells. Nucleic Acids Res. 1988 Feb 11; 16(3):1043-61. Bunch TA, Grinblat Y, Goldstein LS. PMID: 3125519.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    168. Drosophilia spectrin. I. Characterization of the purified protein. J Cell Biol. 1987 Nov; 105(5):2095-102. Dubreuil R, Byers TJ, Branton D, Goldstein LS, Kiehart DP. PMID: 3680372.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    169. Drosophila spectrin. II. Conserved features of the alpha-subunit are revealed by analysis of cDNA clones and fusion proteins. J Cell Biol. 1987 Nov; 105(5):2103-10. Byers TJ, Dubreuil R, Branton D, Kiehart DP, Goldstein LS. PMID: 2824526.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    170. A microtubule-associated protein in Drosophila melanogaster: identification, characterization, and isolation of coding sequences. J Cell Biol. 1986 Jun; 102(6):2076-87. Goldstein LS, Laymon RA, McIntosh JR. PMID: 3086324.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    171. Kinetochore structure and its role in chromosome orientation during the first meiotic division in male D. melanogaster. Cell. 1981 Sep; 25(3):591-602. Goldstein LS. PMID: 6793236.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    172. Detecting mutations expressed during early development of cultured mammalian embryos. Genetics. 1979 May; 92(1 Pt 1 Suppl):s143-51. Pedersen RA, Goldstein LS. PMID: 488698.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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