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Lawrence Goldstein

Title(s)Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
Phone858-534-9702
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    Collapse Overview 
    Collapse Overview
    The primary goals in the Goldstein lab are to unravel how molecular motors interact with, and control the behavior of, axonal vesicles, and to relate this understanding to the molecular basis of neuronal defects in Alzheimer's Disease (AD) and Niemann Pick type C disease.

    We are taking advantage of pluripotent stem cell lines that contain known mutations that cause hereditary Alzheimer's disease, as well as Niemann Pick Type C disease. This latter disease is of interest because it directly ties cholesterol trafficking and transport to what appears to be a pediatric form of Alzheimer type dementia.

    We are also using these cell lines and animal models to probe basic mechanisms of vesicle movement and sorting in neurons, and how such mechanisms inter-relate with disease development. In a related endeavor, we are probing how genetic variation predisposes to different neuronal phenotypes and disease by developing pluripotent stem cell lines carrying genomes of people who developed sporadic Alzheimer's disease or in one case carry susceptibility elements (from Craig Venter whose diploid genome is completely sequenced and which is known to harbor Alzheimer susceptibility variants).

    To study these problems, we have collaborated with BD biosciences to develop new quantitative methods for generating and purifying neurons made from human embryonic stem cells and induced pluripotent stem cells. We have also developed quantitative methods for evaluating AD phenotypes in these cells. Finally, building upon collaborative work with the Cleveland laboratory, we are developing a potential therapy for ALS (a.k.a. Lou Gehrig's disease) by using human embryonic stem cells to generate human astrocyte progenitors, which are being tested in animal models for safety and effectiveness. We hope that this investigation will lead to clinical trials in the coming years.

    Research Focus Areas:


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    Collapse Research Activities and Funding
    Probing the molecular and cellular complexity of APP trafficking and its relationship to AD.
    NIH/NIA R56AG054013Sep 30, 2017 - Aug 31, 2018
    Role: Principal Investigator
    Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
    NIH/NIMH U19MH107367Sep 21, 2015 - Jun 30, 2020
    Role: Co-Investigator
    Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method
    NIH/NIGMS R44GM112442Sep 1, 2014 - Jun 30, 2017
    Role: Principal Investigator
    Elucidating AD genotype-phenotype relationships using genetics of human IPS cells
    NIH/NIA RF1AG048083Aug 15, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Testing cell autonomy of AD phenotypes using human IPS cells
    NIH/NINDS R21NS076869May 1, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Pluripotent stem cell models of sporadic Alzheimer's Disease
    NIH/NIA R21AG038849Sep 1, 2011 - Jun 30, 2013
    Role: Principal Investigator
    REGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTES
    NIH/NHLBI U01HL107442Jul 15, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Human Stem Cell Model of Niemann Pick Type C
    NIH/NINDS RC1NS068705Apr 15, 2010 - Mar 31, 2012
    Role: Principal Investigator
    Impairment of axonal transport by Amyloid precursor protein and amyloid Beta-prot
    NIH/NIA R01AG032180Sep 15, 2007 - Aug 31, 2012
    Role: Principal Investigator
    Genetic Analysis of Dendritic Targeting
    NIH/FIC R03TW005784Dec 14, 2001 - Nov 30, 2004
    Role: Principal Investigator
    Training Program in Basic and Clinical Genetics
    NIH/NIGMS T32GM008666Jul 1, 1998 - Jun 30, 2022
    Role: Principal Investigator
    GENETIC AND IMMUNOLOGIC ANALYSIS OF MICROTUBULE PROTEINS
    NIH/NIGMS R01GM035252Aug 30, 1985 - Jul 31, 2007
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH/NIA P50AG005131Sep 28, 1984 - Mar 31, 2019
    Role: Co-Investigator
    Administrative Core
    NIH/NIMH U19MH-01
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-ß in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. 2019 Mar 07; 24(3):363-375.e9. PMID: 30686764.
      View in: PubMed
    2. Fong LK, Yang MM, Dos Santos Chaves R, Reyna SM, Langness VF, Woodruff G, Roberts EA, Young JE, Goldstein LSB. Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-ß clearance in human astrocytes. J Biol Chem. 2018 07 20; 293(29):11341-11357. PMID: 29858247.
      View in: PubMed
    3. Young JE, Fong LK, Frankowski H, Petsko GA, Small SA, Goldstein LSB. Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein. Stem Cell Reports. 2018 03 13; 10(3):1046-1058. PMID: 29503090.
      View in: PubMed
    4. D'Antonio M, Woodruff G, Nathanson JL, D'Antonio-Chronowska A, Arias A, Matsui H, Williams R, Herrera C, Reyna SM, Yeo GW, Goldstein LSB, Panopoulos AD, Frazer KA. High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 04 11; 8(4):1101-1111. PMID: 28410643.
      View in: PubMed
    5. Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MKR, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans SM, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein LSB, Izpisua Belmonte JC, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. Stem Cell Reports. 2017 04 11; 8(4):1086-1100. PMID: 28410642.
      View in: PubMed
    6. Woodruff G, Reyna SM, Dunlap M, Van Der Kant R, Callender JA, Young JE, Roberts EA, Goldstein LS. Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations. Cell Rep. 2016 10 11; 17(3):759-773. PMID: 27732852.
      View in: PubMed
    7. Howe KP, Clochesy JM, Goldstein LS, Owen H. Mechanical Ventilation Antioxidant Trial. Am J Crit Care. 2015 Sep; 24(5):440-5. PMID: 26330437.
      View in: PubMed
    8. Young JE, Boulanger-Weill J, Williams DA, Woodruff G, Buen F, Revilla AC, Herrera C, Israel MA, Yuan SH, Edland SD, Goldstein LS. Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells. Cell Stem Cell. 2015 Apr 02; 16(4):373-85. PMID: 25772071.
      View in: PubMed
    9. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. A ?-secretase inhibitor, but not a ?-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. PMID: 25710492.
      View in: PubMed
    10. van der Kant R, Goldstein LS. Cellular functions of the amyloid precursor protein from development to dementia. Dev Cell. 2015 Feb 23; 32(4):502-15. PMID: 25710536.
      View in: PubMed
    11. Goldstein LS, Reyna S, Woodruff G. Probing the secrets of Alzheimer's disease using human-induced pluripotent stem cell technology. Neurotherapeutics. 2015 Jan; 12(1):121-5. PMID: 25534395; PMCID: PMC4322074.
    12. Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. Effect of potent ?-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014 Dec; 71(12):1481-9. PMID: 25285942.
      View in: PubMed
    13. Niederst ED, Reyna SM, Goldstein LS. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Mol Biol Cell. 2015 Jan 15; 26(2):205-17. PMID: 25392299; PMCID: PMC4294669.
    14. Neumann S, Campbell GE, Szpankowski L, Goldstein LS, Encalada SE. Characterizing the composition of molecular motors on moving axonal cargo using "cargo mapping" analysis. J Vis Exp. 2014 Oct 30; (92):e52029. PMID: 25406537; PMCID: PMC4353387.
    15. Lu P, Woodruff G, Wang Y, Graham L, Hunt M, Wu D, Boehle E, Ahmad R, Poplawski G, Brock J, Goldstein LS, Tuszynski MH. Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury. Neuron. 2014 Aug 20; 83(4):789-96. PMID: 25123310; PMCID: PMC4144679.
    16. Almenar-Queralt A, Falzone TL, Shen Z, Lillo C, Killian RL, Arreola AS, Niederst ED, Ng KS, Kim SN, Briggs SP, Williams DS, Goldstein LS. UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. J Neurosci. 2014 Feb 26; 34(9):3320-39. PMID: 24573290; PMCID: PMC3935090.
    17. Otero MG, Alloatti M, Cromberg LE, Almenar-Queralt A, Encalada SE, Pozo Devoto VM, Bruno L, Goldstein LS, Falzone TL. Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function. J Cell Sci. 2014 Apr 01; 127(Pt 7):1537-49. PMID: 24522182.
      View in: PubMed
    18. Encalada SE, Goldstein LS. Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration. Annu Rev Biophys. 2014; 43:141-69. PMID: 24702007.
      View in: PubMed
    19. Woodruff G, Young JE, Martinez FJ, Buen F, Gore A, Kinaga J, Li Z, Yuan SH, Zhang K, Goldstein LS. The presenilin-1 ?E9 mutation results in reduced ?-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. Cell Rep. 2013 Nov 27; 5(4):974-85. PMID: 24239350; PMCID: PMC3867011.
    20. Almenar-Queralt A, Kim SN, Benner C, Herrera CM, Kang DE, Garcia-Bassets I, Goldstein LS. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013 Dec 06; 288(49):35222-36. PMID: 24145027; PMCID: PMC3853272.
    21. Duncan JE, Lytle NK, Zuniga A, Goldstein LS. The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila. PLoS One. 2013; 8(6):e68324. PMID: 23840848.
      View in: PubMed
    22. Gunawardena S, Yang G, Goldstein LS. Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. Hum Mol Genet. 2013 Oct 01; 22(19):3828-43. PMID: 23710041; PMCID: PMC3766177.
    23. Bianco P, Barker R, Brüstle O, Cattaneo E, Clevers H, Daley GQ, De Luca M, Goldstein L, Lindvall O, Mummery C, Robey PG, Sattler de Sousa E Brito C, Smith A. Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. EMBO J. 2013 May 29; 32(11):1489-95. PMID: 23644381.
      View in: PubMed
    24. Haimes E, Skene L, Ballantyne AJ, Caulfield T, Goldstein LS, Hyun I, Kimmelman J, Robert JS, Roxland BE, Scott CT, Solbakk JH, Sugarman J, Taylor PL, Testa G. Position statement on the provision and procurement of human eggs for stem cell research. Cell Stem Cell. 2013 Mar 07; 12(3):285-91. PMID: 23472870.
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    25. Ordonez MP, Goldstein LS. Using human-induced pluripotent stem cells to model monogenic metabolic disorders of the liver. Semin Liver Dis. 2012 Nov; 32(4):298-306. PMID: 23397530.
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    26. Weaver C, Leidel C, Szpankowski L, Farley NM, Shubeita GT, Goldstein LS. Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein. Traffic. 2013 Mar; 14(3):295-308. PMID: 23279138.
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    27. Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013 Mar 07; 12(3):316-28. PMID: 23333150.
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    28. Jiang Q, Crews LA, Barrett CL, Chun HJ, Court AC, Isquith JM, Zipeto MA, Goff DJ, Minden M, Sadarangani A, Rusert JM, Dao KH, Morris SR, Goldstein LS, Marra MA, Frazer KA, Jamieson CH. ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):1041-6. PMID: 23275297; PMCID: PMC3549099.
    29. Goldstein LS. New frontiers in human cell biology and medicine: can pluripotent stem cells deliver? J Cell Biol. 2012 Nov 12; 199(4):577-81. PMID: 23148231; PMCID: PMC3494862.
    30. Goldstein L. US election: Know your representatives. Nature. 2012 Sep 27; 489(7417):494-5. PMID: 23018948.
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    31. Goldstein LS. An October call to arms: we are research! Mol Biol Cell. 2012 Sep; 23(17):3279-80. PMID: 22936697; PMCID: PMC3431937.
    32. Young JE, Goldstein LS. Alzheimer's disease in a dish: promises and challenges of human stem cell models. Hum Mol Genet. 2012 Oct 15; 21(R1):R82-9. PMID: 22865875; PMCID: PMC3459645.
    33. Rodrigues EM, Weissmiller AM, Goldstein LS. Enhanced ß-secretase processing alters APP axonal transport and leads to axonal defects. Hum Mol Genet. 2012 Nov 01; 21(21):4587-601. PMID: 22843498; PMCID: PMC3471392.
    34. Szpankowski L, Encalada SE, Goldstein LS. Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8582-7. PMID: 22582169; PMCID: PMC3365224.
    35. Goldstein LS. Axonal transport and neurodegenerative disease: can we see the elephant? Prog Neurobiol. 2012 Dec; 99(3):186-90. PMID: 22484448; PMCID: PMC3867006.
    36. Ordonez MP, Roberts EA, Kidwell CU, Yuan SH, Plaisted WC, Goldstein LS. Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Hum Mol Genet. 2012 Jun 15; 21(12):2651-62. PMID: 22437840; PMCID: PMC3363339.
    37. Reis GF, Yang G, Szpankowski L, Weaver C, Shah SB, Robinson JT, Hays TS, Danuser G, Goldstein LS. Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. Mol Biol Cell. 2012 May; 23(9):1700-14. PMID: 22398725; PMCID: PMC3338437.
    38. Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25; 482(7384):216-20. PMID: 22278060; PMCID: PMC3338985.
    39. Killian RL, Flippin JD, Herrera CM, Almenar-Queralt A, Goldstein LS. Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PLoS One. 2012; 7(1):e29755. PMID: 22272245; PMCID: PMC3260181.
    40. Goldstein LS. In the trenches: lessons for scientists from California's Proposition 71 campaign. Mol Biol Cell. 2011 Nov; 22(21):3943-4. PMID: 22039069; PMCID: PMC3204056.
    41. DeQuach JA, Yuan SH, Goldstein LS, Christman KL. Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds. Tissue Eng Part A. 2011 Nov; 17(21-22):2583-92. PMID: 21883047; PMCID: PMC3204197.
    42. Henthorn KS, Roux MS, Herrera C, Goldstein LS. A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. Mol Biol Cell. 2011 Nov; 22(21):4038-46. PMID: 21880894.
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    43. Israel MA, Goldstein LS. Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges. Genome Med. 2011 Jul 27; 3(7):49. PMID: 21867573; PMCID: PMC3221547.
    44. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar 03; 471(7336):63-7. PMID: 21368825; PMCID: PMC3074107.
    45. Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein LS, Carson CT. Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One. 2011 Mar 02; 6(3):e17540. PMID: 21407814; PMCID: PMC3047583.
    46. Encalada SE, Szpankowski L, Xia CH, Goldstein LS. Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Cell. 2011 Feb 18; 144(4):551-65. PMID: 21335237; PMCID: PMC3576050.
    47. Kim JE, O'Sullivan ML, Sanchez CA, Hwang M, Israel MA, Brennand K, Deerinck TJ, Goldstein LS, Gage FH, Ellisman MH, Ghosh A. Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3005-10. PMID: 21278334; PMCID: PMC3041068.
    48. Goldstein LS. Unconventional allies: interdisciplinary approaches to science policy and funding. Trends Cell Biol. 2010 Dec; 20(12):695-8. PMID: 21106464.
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    49. Falzone TL, Gunawardena S, McCleary D, Reis GF, Goldstein LS. Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies. Hum Mol Genet. 2010 Nov 15; 19(22):4399-408. PMID: 20817925; PMCID: PMC2957317.
    50. Taylor PL, Barker RA, Blume KG, Cattaneo E, Colman A, Deng H, Edgar H, Fox IJ, Gerstle C, Goldstein LS, High KA, Lyall A, Parkman R, Pitossi FJ, Prentice ED, Rooke HM, Sipp DA, Srivastava A, Stayn S, Steinberg GK, Wagers AJ, Weissman IL. Patients beware: commercialized stem cell treatments on the web. Cell Stem Cell. 2010 Jul 02; 7(1):43-9. PMID: 20621049.
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    51. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan KL. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010 Jun 01; 24(11):1106-18. PMID: 20516196; PMCID: PMC2878649.
    52. Goldstein L. Why scientific details are important when novel technologies encounter law, politics, and ethics. J Law Med Ethics. 2010; 38(2):204-11. PMID: 20579243.
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    53. Abe N, Almenar-Queralt A, Lillo C, Shen Z, Lozach J, Briggs SP, Williams DS, Goldstein LS, Cavalli V. Sunday driver interacts with two distinct classes of axonal organelles. J Biol Chem. 2009 Dec 11; 284(50):34628-39. PMID: 19801628; PMCID: PMC2787325.
    54. Shah SB, Nolan R, Davis E, Stokin GB, Niesman I, Canto I, Glabe C, Goldstein LS. Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiol Dis. 2009 Oct; 36(1):11-25. PMID: 19497367.
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    55. Falzone TL, Stokin GB, Lillo C, Rodrigues EM, Westerman EL, Williams DS, Goldstein LS. Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. J Neurosci. 2009 May 06; 29(18):5758-67. PMID: 19420244; PMCID: PMC3849468.
    56. Her LS, Goldstein LS. Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J Neurosci. 2008 Dec 10; 28(50):13662-72. PMID: 19074039.
      View in: PubMed
    57. Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS. Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Hum Mol Genet. 2008 Nov 15; 17(22):3474-86. PMID: 18694898; PMCID: PMC2722897.
    58. Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein LS. Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7594-9. PMID: 18492803; PMCID: PMC2396671.
    59. Haghnia M, Cavalli V, Shah SB, Schimmelpfeng K, Brusch R, Yang G, Herrera C, Pilling A, Goldstein LS. Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment. Mol Biol Cell. 2007 Jun; 18(6):2081-9. PMID: 17360970.
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    60. Daley GQ, Ahrlund Richter L, Auerbach JM, Benvenisty N, Charo RA, Chen G, Deng HK, Goldstein LS, Hudson KL, Hyun I, Junn SC, Love J, Lee EH, McLaren A, Mummery CL, Nakatsuji N, Racowsky C, Rooke H, Rossant J, Schöler HR, Solbakk JH, Taylor P, Trounson AO, Weissman IL, Wilmut I, Yu J, Zoloth L. Ethics. The ISSCR guidelines for human embryonic stem cell research. Science. 2007 Feb 02; 315(5812):603-4. PMID: 17272706.
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    61. Jimeno D, Feiner L, Lillo C, Teofilo K, Goldstein LS, Pierce EA, Williams DS. Analysis of kinesin-2 function in photoreceptor cells using synchronous Cre-loxP knockout of Kif3a with RHO-Cre. Invest Ophthalmol Vis Sci. 2006 Nov; 47(11):5039-46. PMID: 17065525; PMCID: PMC1904505.
    62. Duncan JE, Goldstein LS. The genetics of axonal transport and axonal transport disorders. PLoS Genet. 2006 Sep 29; 2(9):e124. PMID: 17009871; PMCID: PMC1584265.
    63. Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42. PMID: 16815330.
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    64. Stokin GB, Goldstein LS. Linking molecular motors to Alzheimer's disease. J Physiol Paris. 2006 Mar-May; 99(2-3):193-200. PMID: 16459060.
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    65. Stokin GB, Goldstein LS. Axonal transport and Alzheimer's disease. Annu Rev Biochem. 2006; 75:607-27. PMID: 16756504.
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    66. Jimeno D, Lillo C, Roberts EA, Goldstein LS, Williams DS. Kinesin-2 and photoreceptor cell death: requirement of motor subunits. Exp Eye Res. 2006 Feb; 82(2):351-3. PMID: 16337628.
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    67. Cavalli V, Kujala P, Klumperman J, Goldstein LS. Sunday Driver links axonal transport to damage signaling. J Cell Biol. 2005 Feb 28; 168(5):775-87. PMID: 15738268; PMCID: PMC2171809.
    68. Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LS. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005 Feb 25; 307(5713):1282-8. PMID: 15731448.
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    69. Gunawardena S, Goldstein LS. Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways. Arch Neurol. 2005 Jan; 62(1):46-51. PMID: 15642849.
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    70. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22. PMID: 15479732.
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    71. Guzik BW, Goldstein LS. Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Curr Opin Cell Biol. 2004 Aug; 16(4):443-50. PMID: 15261678.
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    72. Gunawardena S, Goldstein LS. Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. J Neurobiol. 2004 Feb 05; 58(2):258-71. PMID: 14704957.
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    73. Goldstein LS. Do disorders of movement cause movement disorders and dementia? Neuron. 2003 Oct 09; 40(2):415-25. PMID: 14556718.
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    74. Clement AM, Nguyen MD, Roberts EA, Garcia ML, Boillée S, Rule M, McMahon AP, Doucette W, Siwek D, Ferrante RJ, Brown RH, Julien JP, Goldstein LS, Cleveland DW. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science. 2003 Oct 03; 302(5642):113-7. PMID: 14526083.
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    75. Gunawardena S, Her LS, Brusch RG, Laymon RA, Niesman IR, Gordesky-Gold B, Sintasath L, Bonini NM, Goldstein LS. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron. 2003 Sep 25; 40(1):25-40. PMID: 14527431.
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    109. Bowman AB, Patel-King RS, Benashski SE, McCaffery JM, Goldstein LS, King SM. Drosophila roadblock and Chlamydomonas LC7: a conserved family of dynein-associated proteins involved in axonal transport, flagellar motility, and mitosis. J Cell Biol. 1999 Jul 12; 146(1):165-80. PMID: 10402468.
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    123. Hanlon DW, Yang Z, Goldstein LS. Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. Neuron. 1997 Mar; 18(3):439-51. PMID: 9115737.
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    126. Matthies HJ, McDonald HB, Goldstein LS, Theurkauf WE. Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein. J Cell Biol. 1996 Jul; 134(2):455-64. PMID: 8707829.
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    135. Deng H, Lee JK, Goldstein LS, Branton D. Drosophila development requires spectrin network formation. J Cell Biol. 1995 Jan; 128(1-2):71-9. PMID: 7822424.
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    164. Kiehart DP, Lutz MS, Chan D, Ketchum AS, Laymon RA, Nguyen B, Goldstein LS. Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family. EMBO J. 1989 Mar; 8(3):913-22. PMID: 2498088.
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