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    Lawrence Goldstein

    SchoolUniversity of California, San Diego
    DepartmentCellular and Molecular Medicine
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
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      Collapse Overview 
      Collapse Overview
      The primary goals in the Goldstein lab are to unravel how molecular motors interact with, and control the behavior of, axonal vesicles, and to relate this understanding to the molecular basis of neuronal defects in Alzheimer's Disease (AD) and Niemann Pick type C disease.

      We are taking advantage of pluripotent stem cell lines that contain known mutations that cause hereditary Alzheimer's disease, as well as Niemann Pick Type C disease. This latter disease is of interest because it directly ties cholesterol trafficking and transport to what appears to be a pediatric form of Alzheimer type dementia.

      We are also using these cell lines and animal models to probe basic mechanisms of vesicle movement and sorting in neurons, and how such mechanisms inter-relate with disease development. In a related endeavor, we are probing how genetic variation predisposes to different neuronal phenotypes and disease by developing pluripotent stem cell lines carrying genomes of people who developed sporadic Alzheimer's disease or in one case carry susceptibility elements (from Craig Venter whose diploid genome is completely sequenced and which is known to harbor Alzheimer susceptibility variants).

      To study these problems, we have collaborated with BD biosciences to develop new quantitative methods for generating and purifying neurons made from human embryonic stem cells and induced pluripotent stem cells. We have also developed quantitative methods for evaluating AD phenotypes in these cells. Finally, building upon collaborative work with the Cleveland laboratory, we are developing a potential therapy for ALS (a.k.a. Lou Gehrig's disease) by using human embryonic stem cells to generate human astrocyte progenitors, which are being tested in animal models for safety and effectiveness. We hope that this investigation will lead to clinical trials in the coming years.

      Research Focus Areas:

      Collapse Research 
      Collapse Research Activities and Funding
      Probing the molecular and cellular complexity of APP trafficking and its relationship to AD.
      NIH/NIA R56AG054013Sep 30, 2017 - Aug 31, 2018
      Role: Principal Investigator
      Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
      NIH/NIMH U19MH107367Sep 21, 2015 - Jun 30, 2020
      Role: Co-Investigator
      Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method
      NIH/NIGMS R44GM112442Sep 1, 2014 - Jun 30, 2017
      Role: Principal Investigator
      Elucidating AD genotype-phenotype relationships using genetics of human IPS cells
      NIH/NIA RF1AG048083Aug 15, 2014 - Jun 30, 2019
      Role: Principal Investigator
      Testing cell autonomy of AD phenotypes using human IPS cells
      NIH/NINDS R21NS076869May 1, 2012 - Apr 30, 2014
      Role: Principal Investigator
      Pluripotent stem cell models of sporadic Alzheimer's Disease
      NIH/NIA R21AG038849Sep 1, 2011 - Jun 30, 2013
      Role: Principal Investigator
      NIH/NHLBI U01HL107442Jul 15, 2011 - Jun 30, 2017
      Role: Principal Investigator
      Human Stem Cell Model of Niemann Pick Type C
      NIH/NINDS RC1NS068705Apr 15, 2010 - Mar 31, 2012
      Role: Principal Investigator
      Impairment of axonal transport by Amyloid precursor protein and amyloid Beta-prot
      NIH/NIA R01AG032180Sep 15, 2007 - Aug 31, 2012
      Role: Principal Investigator
      Genetic Analysis of Dendritic Targeting
      NIH/FIC R03TW005784Dec 14, 2001 - Nov 30, 2004
      Role: Principal Investigator
      Training Program in Basic and Clinical Genetics
      NIH/NIGMS T32GM008666Jul 1, 1998 - Jun 30, 2022
      Role: Principal Investigator
      NIH/NIGMS R01GM035252Aug 30, 1985 - Jul 31, 2007
      Role: Principal Investigator
      UCSD Alzheimer's Disease Research Center P50
      NIH/NIA P50AG005131Sep 28, 1984 - Mar 31, 2019
      Role: Co-Investigator
      Administrative Core
      NIH/NIMH U19MH-01
      Role: Co-Investigator

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MKR, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans SM, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein L, Izpisua Belmonte JC, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. Stem Cell Reports. 2017 Apr 11; 8(4):1086-1100. PMID: 28410642.
        View in: PubMed
      2. D'Antonio M, Woodruff G, Nathanson JL, D'Antonio-Chronowska A, Arias A, Matsui H, Williams R, Herrera C, Reyna SM, Yeo GW, Goldstein L, Panopoulos AD, Frazer KA. High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Apr 04. PMID: 28392217.
        View in: PubMed
      3. Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MK, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans SM, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein L, Izpisua Belmonte JC, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. Stem Cell Reports. 2017 Apr 03. PMID: 28392216.
        View in: PubMed
      4. Woodruff G, Reyna SM, Dunlap M, Van Der Kant R, Callender JA, Young JE, Roberts EA, Goldstein L. Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations. Cell Rep. 2016 Oct 11; 17(3):759-773. PMID: 27732852.
        View in: PubMed
      5. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein L, Tanzi RE, Wagner SL, Mobley WC, Wu C. A ?-secretase inhibitor, but not a ?-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. PMID: 25710492; PMCID: PMC4339551.
      6. van der Kant R, Goldstein L. Cellular functions of the amyloid precursor protein from development to dementia. Dev Cell. 2015 Feb 23; 32(4):502-15. PMID: 25710536.
        View in: PubMed
      7. Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein L, Wagner SL, Yuan SH. Effect of potent ?-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014 Dec; 71(12):1481-9. PMID: 25285942; PMCID: PMC4374637.
      8. Niederst ED, Reyna SM, Goldstein L. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Mol Biol Cell. 2015 Jan 15; 26(2):205-17. PMID: 25392299; PMCID: PMC4294669.
      9. Neumann S, Campbell GE, Szpankowski L, Goldstein L, Encalada SE. Characterizing the composition of molecular motors on moving axonal cargo using "cargo mapping" analysis. J Vis Exp. 2014 Oct 30; (92):e52029. PMID: 25406537; PMCID: PMC4353387.
      10. Almenar-Queralt A, Falzone TL, Shen Z, Lillo C, Killian RL, Arreola AS, Niederst ED, Ng KS, Kim SN, Briggs SP, Williams DS, Goldstein L. UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. J Neurosci. 2014 Feb 26; 34(9):3320-39. PMID: 24573290; PMCID: PMC3935090.
      11. Encalada SE, Goldstein L. Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration. Annu Rev Biophys. 2014; 43:141-69. PMID: 24702007.
        View in: PubMed
      12. Gunawardena S, Yang G, Goldstein L. Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. Hum Mol Genet. 2013 Oct 01; 22(19):3828-43. PMID: 23710041; PMCID: PMC3766177.
      13. Ordonez MP, Goldstein L. Using human-induced pluripotent stem cells to model monogenic metabolic disorders of the liver. Semin Liver Dis. 2012 Nov; 32(4):298-306. PMID: 23397530.
        View in: PubMed
      14. Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein L, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013 Mar 07; 12(3):316-28. PMID: 23333150; PMCID: PMC3968867.
      15. Goldstein L. New frontiers in human cell biology and medicine: can pluripotent stem cells deliver? J Cell Biol. 2012 Nov 12; 199(4):577-81. PMID: 23148231; PMCID: PMC3494862.
      16. Goldstein L. US election: Know your representatives. Nature. 2012 Sep 27; 489(7417):494-5. PMID: 23018948.
        View in: PubMed
      17. Goldstein L. An October call to arms: we are research! Mol Biol Cell. 2012 Sep; 23(17):3279-80. PMID: 22936697; PMCID: PMC3431937.
      18. Young JE, Goldstein L. Alzheimer's disease in a dish: promises and challenges of human stem cell models. Hum Mol Genet. 2012 Oct 15; 21(R1):R82-9. PMID: 22865875; PMCID: PMC3459645.
      19. Rodrigues EM, Weissmiller AM, Goldstein L. Enhanced ß-secretase processing alters APP axonal transport and leads to axonal defects. Hum Mol Genet. 2012 Nov 01; 21(21):4587-601. PMID: 22843498; PMCID: PMC3471392.
      20. Szpankowski L, Encalada SE, Goldstein L. Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8582-7. PMID: 22582169; PMCID: PMC3365224.
      21. Goldstein L. Axonal transport and neurodegenerative disease: can we see the elephant? Prog Neurobiol. 2012 Dec; 99(3):186-90. PMID: 22484448; PMCID: PMC3867006.
      22. Ordonez MP, Roberts EA, Kidwell CU, Yuan SH, Plaisted WC, Goldstein L. Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Hum Mol Genet. 2012 Jun 15; 21(12):2651-62. PMID: 22437840; PMCID: PMC3363339.
      23. Reis GF, Yang G, Szpankowski L, Weaver C, Shah SB, Robinson JT, Hays TS, Danuser G, Goldstein L. Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. Mol Biol Cell. 2012 May; 23(9):1700-14. PMID: 22398725; PMCID: PMC3338437.
      24. Killian RL, Flippin JD, Herrera CM, Almenar-Queralt A, Goldstein L. Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PLoS One. 2012; 7(1):e29755. PMID: 22272245; PMCID: PMC3260181.
      25. Goldstein L. In the trenches: lessons for scientists from California's Proposition 71 campaign. Mol Biol Cell. 2011 Nov; 22(21):3943-4. PMID: 22039069; PMCID: PMC3204056.
      26. DeQuach JA, Yuan SH, Goldstein L, Christman KL. Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds. Tissue Eng Part A. 2011 Nov; 17(21-22):2583-92. PMID: 21883047; PMCID: PMC3204197.
      27. Henthorn KS, Roux MS, Herrera C, Goldstein L. A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. Mol Biol Cell. 2011 Nov; 22(21):4038-46. PMID: 21880894; PMCID: PMC3204066.
      28. Israel MA, Goldstein L. Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges. Genome Med. 2011 Jul 27; 3(7):49. PMID: 21867573; PMCID: PMC3221547.
      29. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein L, Zhang K. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar 03; 471(7336):63-7. PMID: 21368825; PMCID: PMC3074107.
      30. Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein L, Carson CT. Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One. 2011 Mar 02; 6(3):e17540. PMID: 21407814; PMCID: PMC3047583.
      31. Encalada SE, Szpankowski L, Xia CH, Goldstein L. Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Cell. 2011 Feb 18; 144(4):551-65. PMID: 21335237; PMCID: PMC3576050.
      32. Kim JE, O'Sullivan ML, Sanchez CA, Hwang M, Israel MA, Brennand K, Deerinck TJ, Goldstein L, Gage FH, Ellisman MH, Ghosh A. Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3005-10. PMID: 21278334; PMCID: PMC3041068.
      33. Goldstein L. Unconventional allies: interdisciplinary approaches to science policy and funding. Trends Cell Biol. 2010 Dec; 20(12):695-8. PMID: 21106464.
        View in: PubMed
      34. Falzone TL, Gunawardena S, McCleary D, Reis GF, Goldstein L. Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies. Hum Mol Genet. 2010 Nov 15; 19(22):4399-408. PMID: 20817925; PMCID: PMC2957317.
      35. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein L, Abujarour R, Ding S, Guan KL. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010 Jun 01; 24(11):1106-18. PMID: 20516196; PMCID: PMC2878649.
      36. Abe N, Almenar-Queralt A, Lillo C, Shen Z, Lozach J, Briggs SP, Williams DS, Goldstein L, Cavalli V. Sunday driver interacts with two distinct classes of axonal organelles. J Biol Chem. 2009 Dec 11; 284(50):34628-39. PMID: 19801628; PMCID: PMC2787325.
      37. Shah SB, Nolan R, Davis E, Stokin GB, Niesman I, Canto I, Glabe C, Goldstein L. Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiol Dis. 2009 Oct; 36(1):11-25. PMID: 19497367.
        View in: PubMed
      38. Falzone TL, Stokin GB, Lillo C, Rodrigues EM, Westerman EL, Williams DS, Goldstein L. Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. J Neurosci. 2009 May 06; 29(18):5758-67. PMID: 19420244; PMCID: PMC3849468.
      39. Her LS, Goldstein L. Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J Neurosci. 2008 Dec 10; 28(50):13662-72. PMID: 19074039.
        View in: PubMed
      40. Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein L. Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Hum Mol Genet. 2008 Nov 15; 17(22):3474-86. PMID: 18694898; PMCID: PMC2722897.
      41. Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein L. Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7594-9. PMID: 18492803; PMCID: PMC2396671.
      42. Haghnia M, Cavalli V, Shah SB, Schimmelpfeng K, Brusch R, Yang G, Herrera C, Pilling A, Goldstein L. Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment. Mol Biol Cell. 2007 Jun; 18(6):2081-9. PMID: 17360970; PMCID: PMC1877108.
      43. Jimeno D, Feiner L, Lillo C, Teofilo K, Goldstein L, Pierce EA, Williams DS. Analysis of kinesin-2 function in photoreceptor cells using synchronous Cre-loxP knockout of Kif3a with RHO-Cre. Invest Ophthalmol Vis Sci. 2006 Nov; 47(11):5039-46. PMID: 17065525; PMCID: PMC1904505.
      44. Duncan JE, Goldstein L. The genetics of axonal transport and axonal transport disorders. PLoS Genet. 2006 Sep 29; 2(9):e124. PMID: 17009871; PMCID: PMC1584265.
      45. Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein L, Mobley WC. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42. PMID: 16815330.
        View in: PubMed
      46. Stokin GB, Goldstein L. Linking molecular motors to Alzheimer's disease. J Physiol Paris. 2006 Mar-May; 99(2-3):193-200. PMID: 16459060.
        View in: PubMed
      47. Stokin GB, Goldstein L. Axonal transport and Alzheimer's disease. Annu Rev Biochem. 2006; 75:607-27. PMID: 16756504.
        View in: PubMed
      48. Jimeno D, Lillo C, Roberts EA, Goldstein L, Williams DS. Kinesin-2 and photoreceptor cell death: requirement of motor subunits. Exp Eye Res. 2006 Feb; 82(2):351-3. PMID: 16337628.
        View in: PubMed
      49. Cavalli V, Kujala P, Klumperman J, Goldstein L. Sunday Driver links axonal transport to damage signaling. J Cell Biol. 2005 Feb 28; 168(5):775-87. PMID: 15738268; PMCID: PMC2171809.
      50. Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein L. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005 Feb 25; 307(5713):1282-8. PMID: 15731448.
        View in: PubMed
      51. Gunawardena S, Goldstein L. Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways. Arch Neurol. 2005 Jan; 62(1):46-51. PMID: 15642849.
        View in: PubMed
      52. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein L, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22. PMID: 15479732; PMCID: PMC2041940.
      53. Guzik BW, Goldstein L. Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Curr Opin Cell Biol. 2004 Aug; 16(4):443-50. PMID: 15261678.
        View in: PubMed
      54. Gunawardena S, Goldstein L. Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. J Neurobiol. 2004 Feb 05; 58(2):258-71. PMID: 14704957.
        View in: PubMed
      55. Goldstein L. Do disorders of movement cause movement disorders and dementia? Neuron. 2003 Oct 09; 40(2):415-25. PMID: 14556718.
        View in: PubMed
      56. Gunawardena S, Her LS, Brusch RG, Laymon RA, Niesman IR, Gordesky-Gold B, Sintasath L, Bonini NM, Goldstein L. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron. 2003 Sep 25; 40(1):25-40. PMID: 14527431.
        View in: PubMed
      57. Xia CH, Roberts EA, Her LS, Liu X, Williams DS, Cleveland DW, Goldstein L. Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol. 2003 Apr 14; 161(1):55-66. PMID: 12682084; PMCID: PMC2172877.
      58. Lin F, Hiesberger T, Cordes K, Sinclair AM, Goldstein L, Somlo S, Igarashi P. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5286-91. PMID: 12672950; PMCID: PMC154337.
      59. Chang L, Jones Y, Ellisman MH, Goldstein L, Karin M. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell. 2003 Apr; 4(4):521-33. PMID: 12689591.
        View in: PubMed
      60. Kamal A, Goldstein L. Principles of cargo attachment to cytoplasmic motor proteins. Curr Opin Cell Biol. 2002 Feb; 14(1):63-8. PMID: 11792546.
        View in: PubMed
      61. Goldstein L. Molecular motors: from one motor many tails to one motor many tales. Trends Cell Biol. 2001 Dec; 11(12):477-82. PMID: 11719052.
        View in: PubMed
      62. Goldstein L. Kinesin molecular motors: transport pathways, receptors, and human disease. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):6999-7003. PMID: 11416178; PMCID: PMC34613.
      63. Goldstein L. Transduction. When worlds collide--trafficking in JNK. Science. 2001 Mar 16; 291(5511):2102-3. PMID: 11256408.
        View in: PubMed
      64. Goldstein L, Gunawardena S. Flying through the drosophila cytoskeletal genome. J Cell Biol. 2000 Jul 24; 150(2):F63-8. PMID: 10908588; PMCID: PMC2180230.
      65. Goldstein L, Yang Z. Microtubule-based transport systems in neurons: the roles of kinesins and dyneins. Annu Rev Neurosci. 2000; 23:39-71. PMID: 10845058.
        View in: PubMed
      66. Goldstein L, Philp AV. The road less traveled: emerging principles of kinesin motor utilization. Annu Rev Cell Dev Biol. 1999; 15:141-83. PMID: 10611960.
        View in: PubMed
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