Lawrence Goldstein

Title(s)Emeritus Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview 
    Collapse Overview
    The primary goals in the Goldstein lab are to unravel how molecular motors interact with, and control the behavior of, axonal vesicles, and to relate this understanding to the molecular basis of neuronal defects in Alzheimer's Disease (AD) and Niemann Pick type C disease.

    We are taking advantage of pluripotent stem cell lines that contain known mutations that cause hereditary Alzheimer's disease, as well as Niemann Pick Type C disease. This latter disease is of interest because it directly ties cholesterol trafficking and transport to what appears to be a pediatric form of Alzheimer type dementia.

    We are also using these cell lines and animal models to probe basic mechanisms of vesicle movement and sorting in neurons, and how such mechanisms inter-relate with disease development. In a related endeavor, we are probing how genetic variation predisposes to different neuronal phenotypes and disease by developing pluripotent stem cell lines carrying genomes of people who developed sporadic Alzheimer's disease or in one case carry susceptibility elements (from Craig Venter whose diploid genome is completely sequenced and which is known to harbor Alzheimer susceptibility variants).

    To study these problems, we have collaborated with BD biosciences to develop new quantitative methods for generating and purifying neurons made from human embryonic stem cells and induced pluripotent stem cells. We have also developed quantitative methods for evaluating AD phenotypes in these cells. Finally, building upon collaborative work with the Cleveland laboratory, we are developing a potential therapy for ALS (a.k.a. Lou Gehrig's disease) by using human embryonic stem cells to generate human astrocyte progenitors, which are being tested in animal models for safety and effectiveness. We hope that this investigation will lead to clinical trials in the coming years.

    Research Focus Areas:


    Collapse Research 
    Collapse Research Activities and Funding
    Probing the molecular and cellular complexity of APP trafficking and its relationship to AD.
    NIH R56AG054013Sep 30, 2017 - Aug 31, 2018
    Role: Principal Investigator
    Collaboration on preclinical autism cellular assays, biosignatures, and network analyses (Copacabana)
    NIH U19MH107367Sep 21, 2015 - Jun 30, 2021
    Role: Co-Investigator
    Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method
    NIH R44GM112442Sep 1, 2014 - Jun 30, 2017
    Role: Principal Investigator
    Elucidating AD genotype-phenotype relationships using genetics of human IPS cells
    NIH RF1AG048083Aug 15, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Testing cell autonomy of AD phenotypes using human IPS cells
    NIH R21NS076869May 1, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Pluripotent stem cell models of sporadic Alzheimer's Disease
    NIH R21AG038849Sep 1, 2011 - Jun 30, 2013
    Role: Principal Investigator
    REGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTES
    NIH U01HL107442Jul 15, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Human Stem Cell Model of Niemann Pick Type C
    NIH RC1NS068705Apr 15, 2010 - Mar 31, 2012
    Role: Principal Investigator
    Impairment of axonal transport by Amyloid precursor protein and amyloid Beta-prot
    NIH R01AG032180Sep 15, 2007 - Aug 31, 2012
    Role: Principal Investigator
    Genetic Analysis of Dendritic Targeting
    NIH R03TW005784Dec 14, 2001 - Nov 30, 2004
    Role: Principal Investigator
    Training Program in Basic and Clinical Genetics
    NIH T32GM008666Jul 1, 1998 - Jun 30, 2022
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH P50AG005131Apr 1, 1997 - Mar 31, 2020
    Role: Co-Investigator
    GENETIC AND IMMUNOLOGIC ANALYSIS OF MICROTUBULE PROTEINS
    NIH R01GM035252Aug 30, 1985 - Jul 31, 2007
    Role: Principal Investigator
    Administrative Core
    NIH/NIMH U19MH-01
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Cell Stem Cell. 2021 Apr 21. Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Böhnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yang L, Karbacher L, Edenhofer F, Stern S, Horvath S, Paquola ACM, Glass CK, Yuan SH, Ku M, Szücs A, Goldstein LSB, Galasko D, Gage FH. PMID: 33910058.
      View in: PubMed   Mentions:    Fields:    
    2. Stem cells on the ballot. Science. 2021 01 15; 371(6526):215. Goldstein LSB, Klein RN. PMID: 33446531.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Balancing Scientific Advice with Political Realities during the Campaign to Pass California's Ballot Proposition 14. Cell Stem Cell. 2021 01 07; 28(1):12-16. Goldstein LSB. PMID: 33417866.
      View in: PubMed   Mentions:    Fields:    
    4. Cholesterol-lowering drugs reduce APP processing to Aß by inducing APP dimerization. Mol Biol Cell. 2021 02 01; 32(3):247-259. Langness VF, van der Kant R, Das U, Wang L, Chaves RDS, Goldstein LSB. PMID: 33296223.
      View in: PubMed   Mentions: 1     Fields:    
    5. The cellular machinery of post-endocytic APP trafficking in Alzheimer's disease: A future target for therapeutic intervention? Prog Mol Biol Transl Sci. 2021; 177:109-122. Goldstein LSB, Das U. PMID: 33453937.
      View in: PubMed   Mentions:    Fields:    
    6. Amyloid-ß-independent regulators of tau pathology in Alzheimer disease. Nat Rev Neurosci. 2020 01; 21(1):21-35. van der Kant R, Goldstein LSB, Ossenkoppele R. PMID: 31780819.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    7. Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells. Nat Genet. 2019 12; 51(12):1691-1701. Almenar-Queralt A, Merkurjev D, Kim HS, Navarro M, Ma Q, Chaves RS, Allegue C, Driscoll SP, Chen AG, Kohlnhofer B, Fong LK, Woodruff G, Mackintosh C, Bohaciakova D, Hruska-Plochan M, Tadokoro T, Young JE, El Hajj N, Dittrich M, Marsala M, Goldstein LSB, Garcia-Bassets I. PMID: 31740836.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    8. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-ß in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. 2019 03 07; 24(3):363-375.e9. van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB. PMID: 30686764.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    9. Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-ß clearance in human astrocytes. J Biol Chem. 2018 07 20; 293(29):11341-11357. Fong LK, Yang MM, Dos Santos Chaves R, Reyna SM, Langness VF, Woodruff G, Roberts EA, Young JE, Goldstein LSB. PMID: 29858247.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    10. Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein. Stem Cell Reports. 2018 03 13; 10(3):1046-1058. Young JE, Fong LK, Frankowski H, Petsko GA, Small SA, Goldstein LSB. PMID: 29503090.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    11. High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 04 11; 8(4):1101-1111. D'Antonio M, Woodruff G, Nathanson JL, D'Antonio-Chronowska A, Arias A, Matsui H, Williams R, Herrera C, Reyna SM, Yeo GW, Goldstein LSB, Panopoulos AD, Frazer KA. PMID: 28410643.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    12. iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. Stem Cell Reports. 2017 04 11; 8(4):1086-1100. Panopoulos AD, D'Antonio M, Benaglio P, Williams R, Hashem SI, Schuldt BM, DeBoever C, Arias AD, Garcia M, Nelson BC, Harismendy O, Jakubosky DA, Donovan MKR, Greenwald WW, Farnam K, Cook M, Borja V, Miller CA, Grinstein JD, Drees F, Okubo J, Diffenderfer KE, Hishida Y, Modesto V, Dargitz CT, Feiring R, Zhao C, Aguirre A, McGarry TJ, Matsui H, Li H, Reyna J, Rao F, O'Connor DT, Yeo GW, Evans SM, Chi NC, Jepsen K, Nariai N, Müller FJ, Goldstein LSB, Izpisua Belmonte JC, Adler E, Loring JF, Berggren WT, D'Antonio-Chronowska A, Smith EN, Frazer KA. PMID: 28410642.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    13. Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations. Cell Rep. 2016 10 11; 17(3):759-773. Woodruff G, Reyna SM, Dunlap M, Van Der Kant R, Callender JA, Young JE, Roberts EA, Goldstein LS. PMID: 27732852.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    14. Mechanical Ventilation Antioxidant Trial. Am J Crit Care. 2015 Sep; 24(5):440-5. Howe KP, Clochesy JM, Goldstein LS, Owen H. PMID: 26330437.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    15. Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells. Cell Stem Cell. 2015 Apr 02; 16(4):373-85. Young JE, Boulanger-Weill J, Williams DA, Woodruff G, Buen F, Revilla AC, Herrera C, Israel MA, Yuan SH, Edland SD, Goldstein LS. PMID: 25772071.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    16. A ?-secretase inhibitor, but not a ?-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. PMID: 25710492.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    17. Cellular functions of the amyloid precursor protein from development to dementia. Dev Cell. 2015 Feb 23; 32(4):502-15. van der Kant R, Goldstein LS. PMID: 25710536.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    18. Probing the secrets of Alzheimer's disease using human-induced pluripotent stem cell technology. Neurotherapeutics. 2015 Jan; 12(1):121-5. Goldstein LS, Reyna S, Woodruff G. PMID: 25534395.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. Effect of potent ?-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014 Dec; 71(12):1481-9. Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. PMID: 25285942.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    20. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Mol Biol Cell. 2015 Jan 15; 26(2):205-17. Niederst ED, Reyna SM, Goldstein LS. PMID: 25392299.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    21. Characterizing the composition of molecular motors on moving axonal cargo using "cargo mapping" analysis. J Vis Exp. 2014 Oct 30; (92):e52029. Neumann S, Campbell GE, Szpankowski L, Goldstein LS, Encalada SE. PMID: 25406537.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury. Neuron. 2014 Aug 20; 83(4):789-96. Lu P, Woodruff G, Wang Y, Graham L, Hunt M, Wu D, Boehle E, Ahmad R, Poplawski G, Brock J, Goldstein LS, Tuszynski MH. PMID: 25123310.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    23. UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. J Neurosci. 2014 Feb 26; 34(9):3320-39. Almenar-Queralt A, Falzone TL, Shen Z, Lillo C, Killian RL, Arreola AS, Niederst ED, Ng KS, Kim SN, Briggs SP, Williams DS, Goldstein LS. PMID: 24573290.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    24. Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function. J Cell Sci. 2014 Apr 01; 127(Pt 7):1537-49. Otero MG, Alloatti M, Cromberg LE, Almenar-Queralt A, Encalada SE, Pozo Devoto VM, Bruno L, Goldstein LS, Falzone TL. PMID: 24522182.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    25. Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration. Annu Rev Biophys. 2014; 43:141-69. Encalada SE, Goldstein LS. PMID: 24702007.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    26. The presenilin-1 ?E9 mutation results in reduced ?-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. Cell Rep. 2013 Nov 27; 5(4):974-85. Woodruff G, Young JE, Martinez FJ, Buen F, Gore A, Kinaga J, Li Z, Yuan SH, Zhang K, Goldstein LS. PMID: 24239350.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    27. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013 Dec 06; 288(49):35222-36. Almenar-Queralt A, Kim SN, Benner C, Herrera CM, Kang DE, Garcia-Bassets I, Goldstein LS. PMID: 24145027.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    28. The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila. PLoS One. 2013; 8(6):e68324. Duncan JE, Lytle NK, Zuniga A, Goldstein LS. PMID: 23840848.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    29. Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. Hum Mol Genet. 2013 Oct 01; 22(19):3828-43. Gunawardena S, Yang G, Goldstein LS. PMID: 23710041.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    30. Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. EMBO J. 2013 May 29; 32(11):1489-95. Bianco P, Barker R, Brüstle O, Cattaneo E, Clevers H, Daley GQ, De Luca M, Goldstein L, Lindvall O, Mummery C, Robey PG, Sattler de Sousa E Brito C, Smith A. PMID: 23644381.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    31. Position statement on the provision and procurement of human eggs for stem cell research. Cell Stem Cell. 2013 Mar 07; 12(3):285-91. Haimes E, Skene L, Ballantyne AJ, Caulfield T, Goldstein LS, Hyun I, Kimmelman J, Robert JS, Roxland BE, Scott CT, Solbakk JH, Sugarman J, Taylor PL, Testa G, ISSCR . PMID: 23472870.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    32. Using human-induced pluripotent stem cells to model monogenic metabolic disorders of the liver. Semin Liver Dis. 2012 Nov; 32(4):298-306. Ordonez MP, Goldstein LS. PMID: 23397530.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    33. Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein. Traffic. 2013 Mar; 14(3):295-308. Weaver C, Leidel C, Szpankowski L, Farley NM, Shubeita GT, Goldstein LS. PMID: 23279138.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    34. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 2013 Mar 07; 12(3):316-28. Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH. PMID: 23333150.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    35. ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):1041-6. Jiang Q, Crews LA, Barrett CL, Chun HJ, Court AC, Isquith JM, Zipeto MA, Goff DJ, Minden M, Sadarangani A, Rusert JM, Dao KH, Morris SR, Goldstein LS, Marra MA, Frazer KA, Jamieson CH. PMID: 23275297.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    36. New frontiers in human cell biology and medicine: can pluripotent stem cells deliver? J Cell Biol. 2012 Nov 12; 199(4):577-81. Goldstein LS. PMID: 23148231.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    37. US election: Know your representatives. Nature. 2012 Sep 27; 489(7417):494-5. Goldstein L. PMID: 23018948.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    38. An October call to arms: we are research! Mol Biol Cell. 2012 Sep; 23(17):3279-80. Goldstein LS. PMID: 22936697.
      View in: PubMed   Mentions: 1     Fields:    
    39. Alzheimer's disease in a dish: promises and challenges of human stem cell models. Hum Mol Genet. 2012 Oct 15; 21(R1):R82-9. Young JE, Goldstein LS. PMID: 22865875.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    40. Enhanced ß-secretase processing alters APP axonal transport and leads to axonal defects. Hum Mol Genet. 2012 Nov 01; 21(21):4587-601. Rodrigues EM, Weissmiller AM, Goldstein LS. PMID: 22843498.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    41. Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8582-7. Szpankowski L, Encalada SE, Goldstein LS. PMID: 22582169.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    42. Axonal transport and neurodegenerative disease: can we see the elephant? Prog Neurobiol. 2012 Dec; 99(3):186-90. Goldstein LS. PMID: 22484448.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    43. Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Hum Mol Genet. 2012 Jun 15; 21(12):2651-62. Ordonez MP, Roberts EA, Kidwell CU, Yuan SH, Plaisted WC, Goldstein LS. PMID: 22437840.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    44. Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. Mol Biol Cell. 2012 May; 23(9):1700-14. Reis GF, Yang G, Szpankowski L, Weaver C, Shah SB, Robinson JT, Hays TS, Danuser G, Goldstein LS. PMID: 22398725.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    45. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25; 482(7384):216-20. Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. PMID: 22278060.
      View in: PubMed   Mentions: 441     Fields:    Translation:HumansCells
    46. Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PLoS One. 2012; 7(1):e29755. Killian RL, Flippin JD, Herrera CM, Almenar-Queralt A, Goldstein LS. PMID: 22272245.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    47. In the trenches: lessons for scientists from California's Proposition 71 campaign. Mol Biol Cell. 2011 Nov; 22(21):3943-4. Goldstein LS. PMID: 22039069.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    48. Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds. Tissue Eng Part A. 2011 Nov; 17(21-22):2583-92. DeQuach JA, Yuan SH, Goldstein LS, Christman KL. PMID: 21883047.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    49. A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. Mol Biol Cell. 2011 Nov; 22(21):4038-46. Henthorn KS, Roux MS, Herrera C, Goldstein LS. PMID: 21880894.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    50. Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges. Genome Med. 2011 Jul 27; 3(7):49. Israel MA, Goldstein LS. PMID: 21867573.
      View in: PubMed   Mentions: 9     Fields:    
    51. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar 03; 471(7336):63-7. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. PMID: 21368825.
      View in: PubMed   Mentions: 521     Fields:    Translation:HumansCells
    52. Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One. 2011 Mar 02; 6(3):e17540. Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein LS, Carson CT. PMID: 21407814.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansAnimalsCells
    53. Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Cell. 2011 Feb 18; 144(4):551-65. Encalada SE, Szpankowski L, Xia CH, Goldstein LS. PMID: 21335237.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    54. Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3005-10. Kim JE, O'Sullivan ML, Sanchez CA, Hwang M, Israel MA, Brennand K, Deerinck TJ, Goldstein LS, Gage FH, Ellisman MH, Ghosh A. PMID: 21278334.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    55. Unconventional allies: interdisciplinary approaches to science policy and funding. Trends Cell Biol. 2010 Dec; 20(12):695-8. Goldstein LS. PMID: 21106464.
      View in: PubMed   Mentions: 1     Fields:    
    56. Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies. Hum Mol Genet. 2010 Nov 15; 19(22):4399-408. Falzone TL, Gunawardena S, McCleary D, Reis GF, Goldstein LS. PMID: 20817925.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    57. Patients beware: commercialized stem cell treatments on the web. Cell Stem Cell. 2010 Jul 02; 7(1):43-9. Taylor PL, Barker RA, Blume KG, Cattaneo E, Colman A, Deng H, Edgar H, Fox IJ, Gerstle C, Goldstein LS, High KA, Lyall A, Parkman R, Pitossi FJ, Prentice ED, Rooke HM, Sipp DA, Srivastava A, Stayn S, Steinberg GK, Wagers AJ, Weissman IL. PMID: 20621049.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    58. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010 Jun 01; 24(11):1106-18. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan KL. PMID: 20516196.
      View in: PubMed   Mentions: 321     Fields:    Translation:HumansAnimalsCells
    59. Why scientific details are important when novel technologies encounter law, politics, and ethics. J Law Med Ethics. 2010; 38(2):204-11. Goldstein L. PMID: 20579243.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    60. Sunday driver interacts with two distinct classes of axonal organelles. J Biol Chem. 2009 Dec 11; 284(50):34628-39. Abe N, Almenar-Queralt A, Lillo C, Shen Z, Lozach J, Briggs SP, Williams DS, Goldstein LS, Cavalli V. PMID: 19801628.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    61. Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiol Dis. 2009 Oct; 36(1):11-25. Shah SB, Nolan R, Davis E, Stokin GB, Niesman I, Canto I, Glabe C, Goldstein LS. PMID: 19497367.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    62. Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. J Neurosci. 2009 May 06; 29(18):5758-67. Falzone TL, Stokin GB, Lillo C, Rodrigues EM, Westerman EL, Williams DS, Goldstein LS. PMID: 19420244.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    63. Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J Neurosci. 2008 Dec 10; 28(50):13662-72. Her LS, Goldstein LS. PMID: 19074039.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    64. Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Hum Mol Genet. 2008 Nov 15; 17(22):3474-86. Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS. PMID: 18694898.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    65. Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7594-9. Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein LS. PMID: 18492803.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    66. Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment. Mol Biol Cell. 2007 Jun; 18(6):2081-9. Haghnia M, Cavalli V, Shah SB, Schimmelpfeng K, Brusch R, Yang G, Herrera C, Pilling A, Goldstein LS. PMID: 17360970.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    67. Ethics. The ISSCR guidelines for human embryonic stem cell research. Science. 2007 Feb 02; 315(5812):603-4. Daley GQ, Ahrlund Richter L, Auerbach JM, Benvenisty N, Charo RA, Chen G, Deng HK, Goldstein LS, Hudson KL, Hyun I, Junn SC, Love J, Lee EH, McLaren A, Mummery CL, Nakatsuji N, Racowsky C, Rooke H, Rossant J, Schöler HR, Solbakk JH, Taylor P, Trounson AO, Weissman IL, Wilmut I, Yu J, Zoloth L. PMID: 17272706.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    68. Analysis of kinesin-2 function in photoreceptor cells using synchronous Cre-loxP knockout of Kif3a with RHO-Cre. Invest Ophthalmol Vis Sci. 2006 Nov; 47(11):5039-46. Jimeno D, Feiner L, Lillo C, Teofilo K, Goldstein LS, Pierce EA, Williams DS. PMID: 17065525.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    69. The genetics of axonal transport and axonal transport disorders. PLoS Genet. 2006 Sep 29; 2(9):e124. Duncan JE, Goldstein LS. PMID: 17009871.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimals
    70. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42. Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC. PMID: 16815330.
      View in: PubMed   Mentions: 222     Fields:    Translation:HumansAnimalsCells
    71. Linking molecular motors to Alzheimer's disease. J Physiol Paris. 2006 Mar-May; 99(2-3):193-200. Stokin GB, Goldstein LS. PMID: 16459060.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    72. Axonal transport and Alzheimer's disease. Annu Rev Biochem. 2006; 75:607-27. Stokin GB, Goldstein LS. PMID: 16756504.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    73. Kinesin-2 and photoreceptor cell death: requirement of motor subunits. Exp Eye Res. 2006 Feb; 82(2):351-3. Jimeno D, Lillo C, Roberts EA, Goldstein LS, Williams DS. PMID: 16337628.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    74. Sunday Driver links axonal transport to damage signaling. J Cell Biol. 2005 Feb 28; 168(5):775-87. Cavalli V, Kujala P, Klumperman J, Goldstein LS. PMID: 15738268.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    75. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005 Feb 25; 307(5713):1282-8. Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LS. PMID: 15731448.
      View in: PubMed   Mentions: 409     Fields:    Translation:HumansAnimalsCells
    76. Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways. Arch Neurol. 2005 Jan; 62(1):46-51. Gunawardena S, Goldstein LS. PMID: 15642849.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    77. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. PMID: 15479732.
      View in: PubMed   Mentions: 265     Fields:    Translation:HumansAnimals
    78. Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Curr Opin Cell Biol. 2004 Aug; 16(4):443-50. Guzik BW, Goldstein LS. PMID: 15261678.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    79. Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. J Neurobiol. 2004 Feb 05; 58(2):258-71. Gunawardena S, Goldstein LS. PMID: 14704957.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    80. Do disorders of movement cause movement disorders and dementia? Neuron. 2003 Oct 09; 40(2):415-25. Goldstein LS. PMID: 14556718.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    81. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron. 2003 Sep 25; 40(1):25-40. Gunawardena S, Her LS, Brusch RG, Laymon RA, Niesman IR, Gordesky-Gold B, Sintasath L, Bonini NM, Goldstein LS. PMID: 14527431.
      View in: PubMed   Mentions: 220     Fields:    Translation:HumansAnimals
    82. Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol. 2003 Apr 14; 161(1):55-66. Xia CH, Roberts EA, Her LS, Liu X, Williams DS, Cleveland DW, Goldstein LS. PMID: 12682084.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    83. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5286-91. Lin F, Hiesberger T, Cordes K, Sinclair AM, Goldstein LS, Somlo S, Igarashi P. PMID: 12672950.
      View in: PubMed   Mentions: 241     Fields:    Translation:AnimalsCells
    84. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell. 2003 Apr; 4(4):521-33. Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. PMID: 12689591.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    85. Loss of heterozygosity analysis of mouse pulmonary adenomas induced by coal tar. Environ Mol Mutagen. 2003; 41(4):300-8. Benavides F, Conti CJ, LaCava M, Flores M, Glasscock E, Sternik G, Gimenez-Conti IB, Johnston DA, Dunsford HA, Goldstein LS, Rodriguez LV. PMID: 12717785.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    86. A genetic screen for suppressors and enhancers of the Drosophila cdk1-cyclin B identifies maternal factors that regulate microtubule and microfilament stability. Genetics. 2002 Nov; 162(3):1179-95. Ji JY, Haghnia M, Trusty C, Goldstein LS, Schubiger G. PMID: 12454065.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    87. Principles of cargo attachment to cytoplasmic motor proteins. Curr Opin Cell Biol. 2002 Feb; 14(1):63-8. Kamal A, Goldstein LS. PMID: 11792546.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    88. Molecular motors: from one motor many tails to one motor many tales. Trends Cell Biol. 2001 Dec; 11(12):477-82. Goldstein LS. PMID: 11719052.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    89. Kinesin molecular motors: transport pathways, receptors, and human disease. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):6999-7003. Goldstein LS. PMID: 11416178.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    90. Transduction. When worlds collide--trafficking in JNK. Science. 2001 Mar 16; 291(5511):2102-3. Goldstein LS. PMID: 11256408.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    91. Flying through the drosophila cytoskeletal genome. J Cell Biol. 2000 Jul 24; 150(2):F63-8. Goldstein LS, Gunawardena S. PMID: 10908588.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    92. Microtubule-based transport systems in neurons: the roles of kinesins and dyneins. Annu Rev Neurosci. 2000; 23:39-71. Goldstein LS, Yang Z. PMID: 10845058.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    93. Adociasulfates 1-6, Inhibitors of Kinesin Motor Proteins from the Sponge Haliclona (aka Adocia) sp. J Org Chem. 1999 Jul 23; 64(15):5565-5570. Blackburn CL, Hopmann C, Sakowicz R, Berdelis MS, Goldstein LS, Faulkner DJ. PMID: 11674622.
      View in: PubMed   Mentions: 6     Fields:    
    94. The road less traveled: emerging principles of kinesin motor utilization. Annu Rev Cell Dev Biol. 1999; 15:141-83. Goldstein LS, Philp AV. PMID: 10611960.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimals
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