Hiromi Wettersten

Title(s)	Assistant Adjunct Professor, Pathology
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
ORCID	0000-0001-7144-3122
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Overview

Websites

Wettersten Lab

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity. Cancer Res. 2024 May 15; 84(10):1630-1642. Nam A, Jain S, Wu C, Campos A, Shepard RM, Yu Z, Reddy JP, Von Schalscha T, Weis SM, Onaitis M, Wettersten HI, Cheresh DA. PMID: 38588407; PMCID: PMC11096068.

View in: PubMed Mentions: 1 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation. Nat Cell Biol. 2023 02; 25(2):309-322. Wu C, Rakhshandehroo T, Wettersten HI, Campos A, von Schalscha T, Jain S, Yu Z, Tan J, Mose E, Childers BG, Lowy AM, Weis SM, Cheresh DA. PMID: 36646789; PMCID: PMC10280815.

View in: PubMed Mentions: 8 Fields:
Cel Cell Biology
Translation:Humans Cells
Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis. Cell Stem Cell. 2020 02 06; 26(2):187-204.e10. Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038; PMCID: PMC9628766.

View in: PubMed Mentions: 98 Fields:
Cel Cell Biology
Translation:Humans Cells
Reprogramming of Metabolism in Kidney Cancer. Semin Nephrol. 2020 01; 40(1):2-13. Wettersten HI. PMID: 32130963.

View in: PubMed Mentions: 23 Fields:
Nep Nephrology
Translation:Humans Cells
Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression. Cancer Res. 2019 10 01; 79(19):5048-5059. Wettersten HI, Weis SM, Pathria P, Von Schalscha T, Minami T, Varner JA, Cheresh DA. PMID: 31416839; PMCID: PMC6774806.

View in: PubMed Mentions: 13 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies. Oncotarget. 2018 Oct 02; 9(77):34567-34581. Baek HB, Lombard AP, Libertini SJ, Fernandez-Rubio A, Vinall R, Gandour-Edwards R, Nakagawa R, Vidallo K, Nishida K, Siddiqui S, Wettersten H, Landesman Y, Weiss RH, Ghosh PM, Mudryj M. PMID: 30349650; PMCID: PMC6195388.

View in: PubMed Mentions: 13 Fields:
Neo Neoplasms
Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis. J Clin Invest. 2018 01 02; 128(1):531-544. Sun Q, Lesperance J, Wettersten H, Luterstein E, DeRose YS, Welm A, Cheresh DA, Desgrosellier JS. PMID: 29227280; PMCID: PMC5749527.

View in: PubMed Mentions: 28 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers. Cancer Discov. 2017 12; 7(12):1464-1479. Seguin L, Camargo MF, Wettersten HI, Kato S, Desgrosellier JS, von Schalscha T, Elliott KC, Cosset E, Lesperance J, Weis SM, Cheresh DA. PMID: 28893801; PMCID: PMC5718959.

View in: PubMed Mentions: 54 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Metabolic reprogramming in clear cell renal cell carcinoma. Nat Rev Nephrol. 2017 07; 13(7):410-419. Wettersten HI, Aboud OA, Lara PN, Weiss RH. PMID: 28480903.

View in: PubMed Mentions: 258 Fields:
Nep Nephrology
Translation:Humans
Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. Oncotarget. 2016 10 11; 7(41):66540-66557. Trott JF, Kim J, Abu Aboud O, Wettersten H, Stewart B, Berryhill G, Uzal F, Hovey RC, Chen CH, Anderson K, Graef A, Sarver AL, Modiano JF, Weiss RH. PMID: 27572319; PMCID: PMC5341819.

View in: PubMed Mentions: 32 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis. Cancer Res. 2015 Jun 15; 75(12):2541-52. Wettersten HI, Hakimi AA, Morin D, Bianchi C, Johnstone ME, Donohoe DR, Trott JF, Aboud OA, Stirdivant S, Neri B, Wolfert R, Stewart B, Perego R, Hsieh JJ, Weiss RH. PMID: 25952651; PMCID: PMC4470795.

View in: PubMed Mentions: 157 Fields:
Neo Neoplasms
Translation:Humans Cells
Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth. PLoS One. 2014; 9(12):e113867. Wettersten HI, Landesman Y, Friedlander S, Shacham S, Kauffman M, Weiss RH. PMID: 25461627; PMCID: PMC4252068.

View in: PubMed Mentions: 17 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Biological evaluation of a novel sorafenib analogue, t-CUPM. Cancer Chemother Pharmacol. 2015 Jan; 75(1):161-71. Wecksler AT, Hwang SH, Liu JY, Wettersten HI, Morisseau C, Wu J, Weiss RH, Hammock BD. PMID: 25413440; PMCID: PMC4400119.

View in: PubMed Mentions: 6 Fields:
Ant Antineoplastic Agents Neo Neoplasms
Translation:Humans Animals Cells
Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels. Am J Physiol Renal Physiol. 2014 Dec 01; 307(11):F1179-86. Tan M, Wettersten HI, Chu K, Huso DL, Watnick T, Friedlander S, Landesman Y, Weiss RH. PMID: 25234309; PMCID: PMC4254973.

View in: PubMed Mentions: 7 Fields:
Nep Nephrology Phy Physiology
Translation:Humans Animals Cells
Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):11127-32. Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu JY, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. PMID: 25024195; PMCID: PMC4121808.

View in: PubMed Mentions: 61 Fields:
Sci Science
Translation:Animals
Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):E3062-71. Gupta R, Dong Y, Solomon PD, Wettersten HI, Cheng CJ, Min JN, Henson J, Dogra SK, Hwang SH, Hammock BD, Zhu LJ, Reddel RR, Saltzman WM, Weiss RH, Chang S, Green MR, Wajapeyee N. PMID: 25024194; PMCID: PMC4121806.

View in: PubMed Mentions: 19 Fields:
Sci Science
Translation:Humans Animals Cells
Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 2014 Apr; 25(4):433-46. Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD. PMID: 24525589; PMCID: PMC3947856.

View in: PubMed Mentions: 1 Fields:
Ant Antineoplastic Agents
Translation:Humans Cells
Mealtime, temporal, and daily variability of the human urinary and plasma metabolomes in a tightly controlled environment. PLoS One. 2014; 9(1):e86223. Kim K, Mall C, Taylor SL, Hitchcock S, Zhang C, Wettersten HI, Jones AD, Chapman A, Weiss RH. PMID: 24475090; PMCID: PMC3901684.

View in: PubMed Mentions: 41 Fields:
Med Medicine (General)Sci Science
Translation:Humans
Metabolomic profiling of tumor-bearing mice. Methods Enzymol. 2014; 543:275-96. Wettersten HI, Ganti S, Weiss RH. PMID: 24924138.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry
Translation:Animals
Anti-inflammatory effects of ω-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol. 2013 Sep; 62(3):285-97. Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif AM, Liu JY, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD. PMID: 23676336; PMCID: PMC3773051.

View in: PubMed Mentions: 61 Fields:
Car Cardiology Pha Pharmacology
Translation:Animals Cells
Inhibition of PPARα induces cell cycle arrest and apoptosis, and synergizes with glycolysis inhibition in kidney cancer cells. PLoS One. 2013; 8(8):e71115. Abu Aboud O, Wettersten HI, Weiss RH. PMID: 23951092; PMCID: PMC3737191.

View in: PubMed Mentions: 42 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Small-molecule inhibitors of p21 as novel therapeutics for chemotherapy-resistant kidney cancer. Future Med Chem. 2013 Jun; 5(9):991-4. Liu R, Wettersten HI, Park SH, Weiss RH. PMID: 23734682; PMCID: PMC4573579.

View in: PubMed Mentions: 17 Fields:
Che Chemistry Pha Pharmacy
Translation:Humans
Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6530-5. Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu JY, Stephen Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. PMID: 23553837; PMCID: PMC3631682.

View in: PubMed Mentions: 137 Fields:
Sci Science
Translation:Humans Animals Cells
Potential biofluid markers and treatment targets for renal cell carcinoma. Nat Rev Urol. 2013 Jun; 10(6):336-44. Wettersten HI, Weiss RH. PMID: 23545813.

View in: PubMed Mentions: 11 Fields:
Uro Urology
Translation:Humans Animals
From bead to flask: Synthesis of a complex β-amido-amide for probe-development studies. Beilstein J Org Chem. 2013; 9:260-4. Martin KS, Soldi C, Candee KN, Wettersten HI, Weiss RH, Shaw JT. PMID: 23400429; PMCID: PMC3566855.

View in: PubMed Mentions:
A novel p21 attenuator which is structurally related to sorafenib. Cancer Biol Ther. 2013 Mar; 14(3):278-85. Wettersten HI, Hee Hwang S, Li C, Shiu EY, Wecksler AT, Hammock BD, Weiss RH. PMID: 23298903; PMCID: PMC3595311.

View in: PubMed Mentions: 33 Fields:
Neo Neoplasms The Therapeutics
Translation:Humans Cells
Applications of metabolomics for kidney disease research: from biomarkers to therapeutic targets. Organogenesis. 2013 Jan-Mar; 9(1):11-8. Wettersten HI, Weiss RH. PMID: 23538740; PMCID: PMC3674034.

View in: PubMed Mentions: 12 Fields:
Bio Biology Bio Biotechnology His Histology
Translation:Humans
CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth. J Urol. 2013 Jun; 189(6):2317-26. Inoue H, Kauffman M, Shacham S, Landesman Y, Yang J, Evans CP, Weiss RH. PMID: 23079374; PMCID: PMC4593314.

View in: PubMed Mentions: 66 Fields:
Uro Urology
Translation:Humans Animals Cells
Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy. Cancer Biol Ther. 2011 Nov 01; 12(9):827-36. Inoue H, Hwang SH, Wecksler AT, Hammock BD, Weiss RH. PMID: 21878748; PMCID: PMC3225758.

View in: PubMed Mentions: 42 Fields:
Neo Neoplasms The Therapeutics
Translation:Humans Cells