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Stephen Wasserman

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0628
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of California, Los Angeles, Los Angeles, CAMD1968Medicine
    Stanford University, Palo Alto, CAAB1964Biology

    Collapse Overview 
    Collapse Overview
    Research Interests
    -Acute inflammation
    -The role of innate immune molecules in the resolution and persistence of otitis media
    -The clinical problem of asthma


    Collapse Research 
    Collapse Research Activities and Funding
    ASTHMA CLINICAL RESEARCH NETWORK
    NIH/NHLBI U10HL074218Sep 15, 2003 - Dec 31, 2011
    Role: Principal Investigator
    Mechanisms of Persistence and Recovery in Otitis Media
    NIH/NIDCD R01DC006279Jul 1, 2003 - Mar 31, 2015
    Role: Principal Investigator
    EFFICACY OF IMMUNOTHERAPY IN MITE ALLERGIC ASTHMA
    NIH/NIAID U01AI021991Sep 30, 1984 - Dec 31, 1990
    Role: Principal Investigator
    RELEASE &EFFECT OF MAST CELL/BASOPHIL MEDIATORS
    NIH/NIAID R01AI017268Jul 1, 1980 - Aug 31, 1990
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ting JP, Tung F, Antonysamy S, Wasserman S, Jones SB, Zhang FF, Espada A, Broughton H, Chalmers MJ, Woodman ME, Bina HA, Dodge JA, Benach J, Zhang A, Groshong C, Manglicmot D, Russell M, Afshar S. Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery. PLoS One. 2018; 13(1):e0190850. PMID: 29329326.
      View in: PubMed
    2. Deniffel D, Nuyen B, Pak K, Suzukawa K, Hung J, Kurabi A, Wasserman S, Ryan AF. Otitis Media and Nasopharyngeal Colonization in ccl3-/- Mice. Infect Immun. 2017 11; 85(11). PMID: 28847849.
      View in: PubMed
    3. Lugogo N, Green CL, Agada N, Zhang S, Meghdadpour S, Zhou R, Yang S, Anstrom KJ, Israel E, Martin R, Lemanske RF, Boushey H, Lazarus SC, Wasserman S, Castro M, Calhoun W, Peters SP, DiMango E, Chinchilli V, Kunselman S, King TS, Icitovic N, Kraft M. Obesity's effect on asthma extends to diagnostic criteria. J Allergy Clin Immunol. 2018 Mar; 141(3):1096-1104. PMID: 28624608.
      View in: PubMed
    4. Bernstein DI, Wasserman S, Thompson WP, Freeman TM. ABAI's MOC Assessment of Knowledge Program Matures: Adding Value with Continuous Learning and Assessment. J Allergy Clin Immunol Pract. 2017 Jan - Feb; 5(1):80-83. PMID: 28065344.
      View in: PubMed
    5. Kurabi A, Pak K, Ryan AF, Wasserman S. Innate Immunity: Orchestrating Inflammation and Resolution of Otitis Media. Curr Allergy Asthma Rep. 2016 Jan; 16(1):6. PMID: 26732809.
      View in: PubMed
    6. Hernandez M, Leichtle A, Pak K, Webster NJ, Wasserman S, Ryan AF. The transcriptome of a complete episode of acute otitis media. BMC Genomics. 2015 Apr 03; 16:259. PMID: 25888408; PMCID: PMC4394589.
    7. Yao W, Frie M, Pan J, Pak K, Webster N, Wasserman S, Ryan AF. C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media. BMC Immunol. 2014 Oct 14; 15:46. PMID: 25311344; PMCID: PMC4200133.
    8. Suzukawa K, Tomlin J, Pak K, Chavez E, Kurabi A, Baird A, Wasserman S, Ryan AF. A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation. PLoS One. 2014; 9(7):e102739. PMID: 25033458; PMCID: PMC4102546.
    9. Kurabi A, Lee J, Wong C, Pak K, Hoffman HM, Ryan AF, Wasserman S. The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media. Innate Immun. 2015 Feb; 21(2):203-14. PMID: 24652041; PMCID: PMC4379507.
    10. Peters SP, Bleecker ER, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger LC, Engle LL, Dimango EA, Israel E, Kraft M, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Wasserman S, Walter MJ, Wechsler ME, Chinchilli VM, Szefler SJ. Predictors of response to tiotropium versus salmeterol in asthmatic adults. J Allergy Clin Immunol. 2013 Nov; 132(5):1068-1074.e1. PMID: 24084072; PMCID: PMC3826080.
    11. Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF, Szefler SJ, Wasserman S, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol. 2013 Aug; 132(2):313-20.e15. PMID: 23541324.
      View in: PubMed
    12. Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman S, Walter MJ, Wechsler ME, Boushey HA. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA. 2012 Sep 12; 308(10):987-97. PMID: 22968888; PMCID: PMC3697088.
    13. Hanania NA, King MJ, Braman SS, Saltoun C, Wise RA, Enright P, Falsey AR, Mathur SK, Ramsdell JW, Rogers L, Stempel DA, Lima JJ, Fish JE, Wilson SR, Boyd C, Patel KV, Irvin CG, Yawn BP, Halm EA, Wasserman S, Sands MF, Ershler WB, Ledford DK. Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshop. J Allergy Clin Immunol. 2011 Sep; 128(3 Suppl):S4-24. PMID: 21872730; PMCID: PMC3164961.
    14. Broderick L, Tourangeau LM, Kavanaugh A, Wasserman S. Biologic modulators in allergic and autoinflammatory diseases. Curr Opin Allergy Clin Immunol. 2011 Aug; 11(4):355-60. PMID: 21659854; PMCID: PMC3154953.
    15. Wasserman S, Vapniarek LJ. MOC CME program. Ann Allergy Asthma Immunol. 2011 Aug; 107(2):183. PMID: 21802030.
      View in: PubMed
    16. Wasserman S. Maintenance of certification and maintenance of professionalism. J Allergy Clin Immunol. 2011 Sep; 128(3):465-6. PMID: 21481445.
      View in: PubMed
    17. Tourangeau LM, Kavanaugh A, Wasserman S. The role of monoclonal antibodies in the treatment of severe asthma. Ther Adv Respir Dis. 2011 Jun; 5(3):183-94. PMID: 21393345.
      View in: PubMed
    18. Leichtle A, Lai Y, Wollenberg B, Wasserman S, Ryan AF. Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep. 2011 Feb; 11(1):78-84. PMID: 21049294; PMCID: PMC3020300.
    19. Ebmeyer J, Leichtle A, Hernandez M, Ebmeyer U, Husseman J, Pak K, Sudhoff H, Broide D, Wasserman S, Ryan AF. TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media. BMC Immunol. 2011 Jan 26; 12:12. PMID: 21269505; PMCID: PMC3040143.
    20. Leichtle A, Hernandez M, Lee J, Pak K, Webster NJ, Wollenberg B, Wasserman S, Ryan AF. The role of DNA sensing and innate immune receptor TLR9 in otitis media. Innate Immun. 2012 Feb; 18(1):3-13. PMID: 21239460; PMCID: PMC4041324.
    21. Huang YJ, Nelson CE, Brodie EL, Desantis TZ, Baek MS, Liu J, Woyke T, Allgaier M, Bristow J, Wiener-Kronish JP, Sutherland ER, King TS, Icitovic N, Martin RJ, Calhoun WJ, Castro M, Denlinger LC, Dimango E, Kraft M, Peters SP, Wasserman S, Wechsler ME, Boushey HA, Lynch SV. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol. 2011 Feb; 127(2):372-381.e1-3. PMID: 21194740; PMCID: PMC3037020.
    22. Sutherland ER, King TS, Icitovic N, Ameredes BT, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Chinchilli VM, Craig TJ, Denlinger L, DiMango EA, Fahy JV, Israel E, Jarjour N, Kraft M, Lazarus SC, Lemanske RF, Peters SP, Ramsdell J, Sorkness CA, Szefler SJ, Walter MJ, Wasserman S, Wechsler ME, Chu HW, Martin RJ. A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin Immunol. 2010 Oct; 126(4):747-53. PMID: 20920764; PMCID: PMC2950827.
    23. Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger L, Engle LL, DiMango EA, Fahy JV, Israel E, Jarjour N, Kazani SD, Kraft M, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman S, Walter MJ, Wechsler ME, Chinchilli VM, Bleecker ER. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010 Oct 28; 363(18):1715-26. PMID: 20979471.
      View in: PubMed
    24. Oseroff C, Sidney J, Kotturi MF, Kolla R, Alam R, Broide DH, Wasserman S, Weiskopf D, McKinney DM, Chung JL, Petersen A, Grey H, Peters B, Sette A. Molecular determinants of T cell epitope recognition to the common Timothy grass allergen. J Immunol. 2010 Jul 15; 185(2):943-55. PMID: 20554959.
      View in: PubMed
    25. Leichtle A, Hernandez M, Ebmeyer J, Yamasaki K, Lai Y, Radek K, Choung YH, Euteneuer S, Pak K, Gallo R, Wasserman S, Ryan AF. CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. J Immunol. 2010 Mar 15; 184(6):3087-97. PMID: 20164426; PMCID: PMC2929161.
    26. Ebmeyer J, Ebmeyer U, Pak K, Sudhoff H, Broide D, Ryan AF, Wasserman S. Reconstitution of the mast cell population in W/Wv mice. Otol Neurotol. 2010 Jan; 31(1):42-7. PMID: 19752767; PMCID: PMC2796298.
    27. Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Denlinger L, Fahy JV, Jarjour N, Kazani S, Kim S, Kraft M, Lazarus SC, Lemanske RF, Markezich A, Martin RJ, Permaul P, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Walter MJ, Wasserman S, Israel E. Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet. 2009 Nov 21; 374(9703):1754-64. PMID: 19932356; PMCID: PMC2914569.
    28. Leichtle A, Hernandez M, Pak K, Webster NJ, Wasserman S, Ryan AF. The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery. BMC Immunol. 2009 Aug 05; 10:45. PMID: 19656404; PMCID: PMC2736931.
    29. Leichtle A, Hernandez M, Pak K, Yamasaki K, Cheng CF, Webster NJ, Ryan AF, Wasserman S. TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media. Innate Immun. 2009 Aug; 15(4):205-15. PMID: 19586996; PMCID: PMC3565845.
    30. Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney DG, Webster NJ, Broide DH, Ryan AF, Wasserman S. Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. J Infect Dis. 2008 Dec 15; 198(12):1862-9. PMID: 18986247; PMCID: PMC3584630.
    31. Craig TJ, King TS, Lemanske RF, Wechsler ME, Icitovic N, Zimmerman RR, Wasserman S. Aeroallergen sensitization correlates with PC(20) and exhaled nitric oxide in subjects with mild-to-moderate asthma. J Allergy Clin Immunol. 2008 Mar; 121(3):671-7. PMID: 18234311.
      View in: PubMed
    32. Serhan CN, Wasserman S. The allergy archives: pioneer and milestones. The discovery and characterization of the leukotrienes. J Allergy Clin Immunol. 2006 Oct; 118(4):972-80. PMID: 17073024.
      View in: PubMed
    33. Zipes DP, Zvaifler NJ, Glassock RJ, Gilman S, Muñoz A, Gogolak V, Gordis L, Dedon PC, Guengerich FP, Wasserman S, Witztum JL, Wogan GN. Rosuvastatin: an independent analysis of risks and benefits. MedGenMed. 2006 Jun 14; 8(2):73. PMID: 16926812; PMCID: PMC1785157.
    34. Ryan AF, Ebmeyer J, Furukawa M, Pak K, Melhus A, Wasserman S, Chung WH. Mouse models of induced otitis media. Brain Res. 2006 May 26; 1091(1):3-8. PMID: 16764829.
      View in: PubMed
    35. Wagelie-Steffen AL, Kavanaugh AF, Wasserman S. Biologic therapies for the treatment of asthma. Clin Chest Med. 2006 Mar; 27(1):133-47, vii. PMID: 16543058.
      View in: PubMed
    36. Ebmeyer J, Furukawa M, Pak K, Ebmeyer U, Sudhoff H, Broide D, Ryan AF, Wasserman S. Role of mast cells in otitis media. J Allergy Clin Immunol. 2005 Nov; 116(5):1129-35. PMID: 16275387.
      View in: PubMed
    37. Wasserman S. 31. Assessment of clinical competence of the allergist/immunologist. J Allergy Clin Immunol. 2003 Feb; 111(2 Suppl):S774-8. PMID: 12592322.
      View in: PubMed
    38. Escoubet-Lozach L, Glass CK, Wasserman S. The role of transcription factors in allergic inflammation. J Allergy Clin Immunol. 2002 Oct; 110(4):553-64. PMID: 12373260.
      View in: PubMed
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