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Perkins, Guy

TitleProject Scientist
InstitutionUniversity of California San Diego
DepartmentCenter for Research in Biological Systems
Address9500 Gilman Drive #0608
La Jolla CA 92093
Phone858-534-9588
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    Collapse Research 
    Collapse Research Activities and Funding
    STRUCTURAL ANALYSIS OF GAP JUNCTION TRAFFICKING
    NIH/NIGMS R01GM072881Feb 1, 2005 - Jun 30, 2016
    Role: Co-Principal Investigator
    STRUCTURE AND DYNAMICS OF CONNEXIN26 GAP JUNCTIONS
    NIH/NIGMS R01GM065937Aug 1, 2003 - Nov 30, 2016
    Role: Principal Investigator
    NATIONAL BIOMEDICAL COMPUTATION RESOURCE
    NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
    Role: Co-Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Liu J, Lee I, Feng HZ, Galen SS, Hüttemann PP, Perkins G, Jin JP, Hüttemann M, Malek MH. Aerobic Exercise Preconception and During Pregnancy Enhances Oxidative Capacity in the Hindlimb Muscles of Mice Offspring. J Strength Cond Res. 2018 May; 32(5):1391-1403. PMID: 29309390.
      View in: PubMed
    2. Zhao H, Perkins G, Yao H, Callacondo D, Appenzeller O, Ellisman M, La Spada AR, Haddad GG. MITOCHONDRIAL DYSFUNCTION IN IPSC-DERIVED NEURONS OF SUBJECTS WITH CHRONIC MOUNTAIN SICKNESS. J Appl Physiol (1985). 2017 Dec 21. PMID: 29357502.
      View in: PubMed
    3. Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor SS, Perkins G. Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50. J Cell Sci. 2017 Oct 01; 130(19):3248-3260. PMID: 28808085.
      View in: PubMed
    4. Koehler CL, Perkins G, Ellisman MH, Jones DL. Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. J Cell Biol. 2017 08 07; 216(8):2315-2327. PMID: 28663346.
      View in: PubMed
    5. Thomas JL, Pham H, Li Y, Hall E, Perkins G, Ali SS, Patel HH, Singh P. Hypoxia-inducible factor-1a activation improves renal oxygenation and mitochondrial function in early chronic kidney disease. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F282-F290. PMID: 28331062.
      View in: PubMed
    6. Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins G, Ju WK. Corrigendum: Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2017 Jan 19; 7:40460. PMID: 28102236.
      View in: PubMed
    7. Yin X, Kidd GJ, Ohno N, Perkins G, Ellisman MH, Bastian C, Brunet S, Baltan S, Trapp BD. Proteolipid protein-deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling. J Cell Biol. 2016 Nov 21; 215(4):531-542. PMID: 27872255.
      View in: PubMed
    8. Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins G, Ju WK. Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2016 Sep 22; 6:33830. PMID: 27654856.
      View in: PubMed
    9. Taub PR, Ramirez-Sanchez I, Patel M, Higginbotham E, Moreno-Ulloa A, Román-Pintos LM, Phillips P, Perkins G, Ceballos G, Villarreal F. Beneficial effects of dark chocolate on exercise capacity in sedentary subjects: underlying mechanisms. A double blind, randomized, placebo controlled trial. Food Funct. 2016 Sep 14; 7(9):3686-93. PMID: 27491778; PMCID: PMC5025384 [Available on 09/14/17].
    10. Tasel SF, Mumcuoglu EU, Hassanpour RZ, Perkins G. A validated active contour method driven by parabolic arc model for detection and segmentation of mitochondria. J Struct Biol. 2016 06; 194(3):253-71. PMID: 26956730.
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    11. Pasqua T, Mahata S, Bandyopadhyay GK, Biswas A, Perkins G, Sinha-Hikim AP, Goldstein DS, Eiden LE, Mahata SK. Erratum to: Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo. Cell Tissue Res. 2016 Mar; 363(3):823. PMID: 26809511.
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    12. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. NF-?B Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910. PMID: 26919428; PMCID: PMC4769378 [Available on 02/25/17].
    13. Rubio-Marrero EN, Vincelli G, Jeffries CM, Shaikh TR, Pakos IS, Ranaivoson FM, von Daake S, Demeler B, De Jaco A, Perkins G, Ellisman MH, Trewhella J, Comoletti D. Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1. J Biol Chem. 2016 Mar 11; 291(11):5788-802. PMID: 26721881; PMCID: PMC4786715 [Available on 03/11/17].
    14. Pasqua T, Mahata S, Bandyopadhyay GK, Biswas A, Perkins G, Sinha-Hikim AP, Goldstein DS, Eiden LE, Mahata SK. Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo. Cell Tissue Res. 2016 Mar; 363(3):693-712. PMID: 26572539.
      View in: PubMed
    15. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. PMID: 26203188; PMCID: PMC4571978.
    16. Perkins G, Jackson DR, Spirou GA. Resolving presynaptic structure by electron tomography. Synapse. 2015 May; 69(5):268-82. PMID: 25683026; PMCID: PMC4955585.
    17. Ju WK, Kim KY, Noh YH, Hoshijima M, Lukas TJ, Ellisman MH, Weinreb RN, Perkins G. Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes. Glia. 2015 May; 63(5):736-53. PMID: 25557093; PMCID: PMC4373968.
    18. Yamazaki KG, Andreyev AY, Ortiz-Vilchis P, Petrosyan S, Divakaruni AS, Wiley SE, De La Fuente C, Perkins G, Ceballos G, Villarreal F, Murphy AN. Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function. Int J Cardiol. 2014 Aug 01; 175(2):297-306. PMID: 24908200; PMCID: PMC4506135.
    19. Perkins G. The use of miniSOG in the localization of mitochondrial proteins. Methods Enzymol. 2014; 547:165-79. PMID: 25416358.
      View in: PubMed
    20. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Gonzalez-Basurto S, Coral-Vazquez R, Perkins G, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa. Clin Sci (Lond). 2013 Oct; 125(8):383-9. PMID: 23642227.
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    21. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins G, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. PMID: 24091324; PMCID: PMC3784521.
    22. Guo Y, Darshi M, Ma Y, Perkins G, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor SS. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. PMID: 24030101; PMCID: PMC3861721.
    23. Yin S, Xue J, Sun H, Wen B, Wang Q, Perkins G, Zhao HW, Ellisman MH, Hsiao YH, Yin L, Xie Y, Hou G, Zi J, Lin L, Haddad GG, Zhou D, Liu S. Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. PLoS One. 2013; 8(9):e74011. PMID: 24069262; PMCID: PMC3771901.
    24. Ramirez-Sanchez I, Taub PR, Ciaraldi TP, Nogueira L, Coe T, Perkins G, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. (-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients. Int J Cardiol. 2013 Oct 09; 168(4):3982-3990. PMID: 23870648; PMCID: PMC3805662.
    25. Hüttemann M, Lee I, Perkins G, Britton SL, Koch LG, Malek MH. (-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity. Clin Sci (Lond). 2013 Jun; 124(11):663-74. PMID: 23252598; PMCID: PMC3715875.
    26. Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN. Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med. 2013 Jun; 5(6):904-18. PMID: 23703906; PMCID: PMC3779451.
    27. Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. The fractalkine/CX3CR1 system regulates ß cell function and insulin secretion. Cell. 2013 Apr 11; 153(2):413-25. PMID: 23582329; PMCID: PMC3717389.
    28. Pamenter ME, Perkins G, Gu XQ, Ellisman MH, Haddad GG. DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress. PLoS One. 2013; 8(4):e60804. PMID: 23577164; PMCID: PMC3618322.
    29. Perkins G, Scott R, Perez A, Ellisman MH, Johnson JE, Fox DA. Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption. Mol Vis. 2012; 18:3029-48. PMID: 23288995; PMCID: PMC3534145.
    30. Pamenter ME, Perkins G, McGinness AK, Gu XQ, Ellisman MH, Haddad GG. Autophagy and apoptosis are differentially induced in neurons and astrocytes treated with an in vitro mimic of the ischemic penumbra. PLoS One. 2012; 7(12):e51469. PMID: 23251543; PMCID: PMC3520810.
    31. Kujjo LL, Acton BM, Perkins G, Ellisman MH, D'Estaing SG, Casper RF, Jurisicova A, Perez GI. Ceramide and its transport protein (CERT) contribute to deterioration of mitochondrial structure and function in aging oocytes. Mech Ageing Dev. 2013 Jan-Feb; 134(1-2):43-52. PMID: 23246342.
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    32. Ramirez-Sanchez I, Nogueira L, Moreno A, Murphy A, Taub P, Perkins G, Ceballos GM, Hogan M, Malek M, Villarreal F. Stimulatory effects of the flavanol (-)-epicatechin on cardiac angiogenesis: additive effects with exercise. J Cardiovasc Pharmacol. 2012 Nov; 60(5):429-38. PMID: 22833114; PMCID: PMC3496054.
    33. Perkins G, Hsiao YH, Yin S, Tjong J, Tran MT, Lau J, Xue J, Liu S, Ellisman MH, Zhou D. Ultrastructural modifications in the mitochondria of hypoxia-adapted Drosophila melanogaster. PLoS One. 2012; 7(9):e45344. PMID: 23028948; PMCID: PMC3446896.
    34. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins G, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. PMID: 22958918; PMCID: PMC3687365.
    35. Pamenter ME, Ryu J, Hua ST, Perkins G, Mendiola VL, Gu XQ, Ellisman MH, Haddad GG. DIDS prevents ischemic membrane degradation in cultured hippocampal neurons by inhibiting matrix metalloproteinase release. PLoS One. 2012; 7(8):e43995. PMID: 22937143; PMCID: PMC3427179.
    36. Vranceanu F, Perkins G, Terada M, Chidavaenzi RL, Ellisman MH, Lysakowski A. Striated organelle, a cytoskeletal structure positioned to modulate hair-cell transduction. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4473-8. PMID: 22396594; PMCID: PMC3311375.
    37. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Perkins G, Murphy AN, Naviaux R, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci. 2012 Feb; 5(1):43-7. PMID: 22376256.
      View in: PubMed
    38. Yamaguchi R, Janssen E, Perkins G, Ellisman M, Kitada S, Reed JC. Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy. PLoS One. 2011; 6(9):e24102. PMID: 21949692; PMCID: PMC3176271.
    39. Nogueira L, Ramirez-Sanchez I, Perkins G, Murphy A, Taub PR, Ceballos G, Villarreal FJ, Hogan MC, Malek MH. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15; 589(Pt 18):4615-31. PMID: 21788351; PMCID: PMC3208228.
    40. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins G, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011 Jun 08; 13(6):690-700. PMID: 21641550; PMCID: PMC3119201.
    41. Day ME, Gaietta GM, Sastri M, Koller A, Mackey MR, Scott JD, Perkins G, Ellisman MH, Taylor SS. Isoform-specific targeting of PKA to multivesicular bodies. J Cell Biol. 2011 Apr 18; 193(2):347-63. PMID: 21502359; PMCID: PMC3080257.
    42. Song W, Chen J, Petrilli A, Liot G, Klinglmayr E, Zhou Y, Poquiz P, Tjong J, Pouladi MA, Hayden MR, Masliah E, Ellisman M, Rouiller I, Schwarzenbacher R, Bossy B, Perkins G, Bossy-Wetzel E. Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nat Med. 2011 Mar; 17(3):377-82. PMID: 21336284; PMCID: PMC3051025.
    43. Suhr ST, Chang EA, Tjong J, Alcasid N, Perkins G, Goissis MD, Ellisman MH, Perez GI, Cibelli JB. Mitochondrial rejuvenation after induced pluripotency. PLoS One. 2010 Nov 23; 5(11):e14095. PMID: 21124794; PMCID: PMC2991355.
    44. Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins G, Ellisman MH, Taylor SS. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem. 2011 Jan 28; 286(4):2918-32. PMID: 21081504; PMCID: PMC3024787.
    45. Perkins G, Ellisman MH. Mitochondrial configurations in peripheral nerve suggest differential ATP production. J Struct Biol. 2011 Jan; 173(1):117-27. PMID: 20600951; PMCID: PMC3078762.
    46. Kim CE, Perez A, Perkins G, Ellisman MH, Dauer WT. A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9861-6. PMID: 20457914; PMCID: PMC2906867.
    47. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins G, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 05; 327(5970):1223-8. PMID: 20203043; PMCID: PMC2866632.
    48. Perkins G, Tjong J, Brown JM, Poquiz PH, Scott RT, Kolson DR, Ellisman MH, Spirou GA. The micro-architecture of mitochondria at active zones: electron tomography reveals novel anchoring scaffolds and cristae structured for high-rate metabolism. J Neurosci. 2010 Jan 20; 30(3):1015-26. PMID: 20089910; PMCID: PMC2829299.
    49. Perkins G, Bossy-Wetzel E, Ellisman MH. New insights into mitochondrial structure during cell death. Exp Neurol. 2009 Aug; 218(2):183-92. PMID: 19464290; PMCID: PMC2712651.
    50. Yamaguchi R, Perkins G. Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1. Biochim Biophys Acta. 2009 Aug; 1787(8):963-72. PMID: 19245786; PMCID: PMC2773558.
    51. Ju WK, Kim KY, Lindsey JD, Angert M, Patel A, Scott RT, Liu Q, Crowston JG, Ellisman MH, Perkins G, Weinreb RN. Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Mol Vis. 2009; 15:120-34. PMID: 19169378; PMCID: PMC2629709.
    52. Perkins G, Sun MG, Frey TG. Chapter 2 Correlated light and electron microscopy/electron tomography of mitochondria in situ. Methods Enzymol. 2009; 456:29-52. PMID: 19348881; PMCID: PMC2730195.
    53. Yamaguchi R, Lartigue L, Perkins G, Scott RT, Dixit A, Kushnareva Y, Kuwana T, Ellisman MH, Newmeyer DD. Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell. 2008 Aug 22; 31(4):557-69. PMID: 18691924; PMCID: PMC2636708.
    54. Knott AB, Perkins G, Schwarzenbacher R, Bossy-Wetzel E. Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci. 2008 Jul; 9(7):505-18. PMID: 18568013; PMCID: PMC2711514.
    55. Bossy B, Perkins G, Bossy-Wetzel E. Clearing the brain's cobwebs: the role of autophagy in neuroprotection. Curr Neuropharmacol. 2008 Jun; 6(2):97-101. PMID: 19305790; PMCID: PMC2647148.
    56. Ju WK, Kim KY, Lindsey JD, Angert M, Duong-Polk KX, Scott RT, Kim JJ, Kukhmazov I, Ellisman MH, Perkins G, Weinreb RN. Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4903-11. PMID: 18469184; PMCID: PMC2688012.
    57. Saini V, Martyshkin DV, Mirov SB, Perez A, Perkins G, Ellisman MH, Towner VD, Wu H, Pereboeva L, Borovjagin A, Curiel DT, Everts M. An adenoviral platform for selective self-assembly and targeted delivery of nanoparticles. Small. 2008 Feb; 4(2):262-9. PMID: 18200644.
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    58. Perkins G, Sosinsky GE, Ghassemzadeh S, Perez A, Jones Y, Ellisman MH. Electron tomographic analysis of cytoskeletal cross-bridges in the paranodal region of the node of Ranvier in peripheral nerves. J Struct Biol. 2008 Mar; 161(3):469-80. PMID: 18096402; PMCID: PMC2346545.
    59. Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, Dalton ND, Thor AK, Perkins G, McCulloch AD, Ross RS. Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol. 2007 Nov; 27(21):7522-37. PMID: 17785437; PMCID: PMC2169049.
    60. Kopek BG, Perkins G, Miller DJ, Ellisman MH, Ahlquist P. Three-dimensional analysis of a viral RNA replication complex reveals a virus-induced mini-organelle. PLoS Biol. 2007 Sep; 5(9):e220. PMID: 17696647; PMCID: PMC1945040.
    61. Sun MG, Williams J, Munoz-Pinedo C, Perkins G, Brown JM, Ellisman MH, Green DR, Frey TG. Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis. Nat Cell Biol. 2007 Sep; 9(9):1057-65. PMID: 17721514.
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    62. Niikura Y, Dixit A, Scott R, Perkins G, Kitagawa K. BUB1 mediation of caspase-independent mitotic death determines cell fate. J Cell Biol. 2007 Jul 16; 178(2):283-96. PMID: 17620410; PMCID: PMC2064447.
    63. Johnson JE, Perkins G, Giddabasappa A, Chaney S, Xiao W, White AD, Brown JM, Waggoner J, Ellisman MH, Fox DA. Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses. Mol Vis. 2007 Jun 15; 13:887-919. PMID: 17653034; PMCID: PMC2774461.
    64. Bielas SL, Serneo FF, Chechlacz M, Deerinck TJ, Perkins G, Allen PB, Ellisman MH, Gleeson JG. Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wrist. Cell. 2007 May 04; 129(3):579-91. PMID: 17482550; PMCID: PMC1920181.
    65. Ju WK, Liu Q, Kim KY, Crowston JG, Lindsey JD, Agarwal N, Ellisman MH, Perkins G, Weinreb RN. Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2145-51. PMID: 17460273.
      View in: PubMed
    66. Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gräber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, Ellisman MH, Perkins G, Bossy-Wetzel E. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J. 2006 Aug 23; 25(16):3900-11. PMID: 16874299; PMCID: PMC1553198.
    67. Smalheiser NR, Torvik VI, Bischoff-Grethe A, Burhans LB, Gabriel M, Homayouni R, Kashef A, Martone ME, Perkins G, Price DL, Talk AC, West R. Collaborative development of the Arrowsmith two node search interface designed for laboratory investigators. J Biomed Discov Collab. 2006 Jul 03; 1:8. PMID: 16817965; PMCID: PMC1559644.
    68. Everts M, Saini V, Leddon JL, Kok RJ, Stoff-Khalili M, Preuss MA, Millican CL, Perkins G, Brown JM, Bagaria H, Nikles DE, Johnson DT, Zharov VP, Curiel DT. Covalently linked Au nanoparticles to a viral vector: potential for combined photothermal and gene cancer therapy. Nano Lett. 2006 Apr; 6(4):587-91. PMID: 16608249.
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    69. Lawrence A, Bouwer JC, Perkins G, Ellisman MH. Transform-based backprojection for volume reconstruction of large format electron microscope tilt series. J Struct Biol. 2006 May; 154(2):144-67. PMID: 16542854.
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    70. Frey TG, Perkins G, Ellisman MH. Electron tomography of membrane-bound cellular organelles. Annu Rev Biophys Biomol Struct. 2006; 35:199-224. PMID: 16689634.
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    71. Smalheiser NR, Perkins G, Jones S. Guidelines for negotiating scientific collaboration. PLoS Biol. 2005 Jun; 3(6):e217. PMID: 15941361; PMCID: PMC1149495.
    72. Perkins G, Ellisman MH, Fox DA. The structure-function correlates of mammalian rod and cone photoreceptor mitochondria: observations and unanswered questions. Mitochondrion. 2004 Sep; 4(5-6):695-703. PMID: 16120425.
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    73. Ricci JE, Muñoz-Pinedo C, Fitzgerald P, Bailly-Maitre B, Perkins G, Yadava N, Scheffler IE, Ellisman MH, Green DR. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell. 2004 Jun 11; 117(6):773-86. PMID: 15186778.
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    74. Bossy-Wetzel E, Talantova MV, Lee WD, Schölzke MN, Harrop A, Mathews E, Götz T, Han J, Ellisman MH, Perkins G, Lipton SA. Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron. 2004 Feb 05; 41(3):351-65. PMID: 14766175.
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    75. Perkins G, Ellisman MH, Fox DA. Three-dimensional analysis of mouse rod and cone mitochondrial cristae architecture: bioenergetic and functional implications. Mol Vis. 2003 Mar 11; 9:60-73. PMID: 12632036.
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    76. He L, Perkins G, Poblenz AT, Harris JB, Hung M, Ellisman MH, Fox DA. Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1022-7. PMID: 12540825; PMCID: PMC298719.
    77. Kuwana T, Mackey MR, Perkins G, Ellisman MH, Latterich M, Schneiter R, Green DR, Newmeyer DD. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell. 2002 Nov 01; 111(3):331-42. PMID: 12419244.
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    78. Uchino H, Minamikawa-Tachino R, Kristián T, Perkins G, Narazaki M, Siesjö BK, Shibasaki F. Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition. Neurobiol Dis. 2002 Aug; 10(3):219-33. PMID: 12270685.
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    79. Renken C, Siragusa G, Perkins G, Washington L, Nulton J, Salamon P, Frey TG. A thermodynamic model describing the nature of the crista junction: a structural motif in the mitochondrion. J Struct Biol. 2002 Apr-May; 138(1-2):137-44. PMID: 12160710.
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