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Perkins, Guy

Title(s)Project Scientist, Center for Research in Biological Systems
SchoolHealth Sciences
Address9500 Gilman Drive #0608
La Jolla CA 92093
Phone858-534-9588
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    Functional and structural analysis of the closed and two open states of the Panx1 channel.
    NIH/NHLBI R56HL136291Sep 15, 2018 - Aug 31, 2019
    Role: Co-Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Aug 13, 2009 - Mar 31, 2014
    Role: Co-Investigator
    STRUCTURAL ANALYSIS OF GAP JUNCTION TRAFFICKING
    NIH/NIGMS R01GM072881Feb 1, 2005 - Jun 30, 2016
    Role: Co-Principal Investigator
    STRUCTURE AND DYNAMICS OF CONNEXIN26 GAP JUNCTIONS
    NIH/NIGMS R01GM065937Aug 1, 2003 - Nov 30, 2016
    Role: Principal Investigator
    NATIONAL BIOMEDICAL COMPUTATION RESOURCE
    NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Altered outer hair cell mitochondrial and subsurface cisternae connectomics are candidate mechanisms for hearing-loss in mice. J Neurosci. 2020 Oct 05. Perkins G, Lee JH, Park S, Kang M, Perez-Flores MC, Ju S, Phillips G, Lysakowski A, Gratton MA, Yamoah EN. PMID: 33020216.
      View in: PubMed   Mentions:    Fields:    
    2. AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration. Redox Biol. 2020 Aug 27; 37:101703. Choi SH, Kim KY, Perkins GA, Phan S, Edwards G, Xia Y, Kim J, Skowronska-Krawczyk D, Weinreb RN, Ellisman MH, Miller YI, Ju WK. PMID: 32896719.
      View in: PubMed   Mentions:    Fields:    
    3. Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. Cell Death Dis. 2020 Apr 20; 11(4):254. Edwards G, Perkins GA, Kim KY, Kong Y, Lee Y, Choi SH, Liu Y, Skowronska-Krawczyk D, Weinreb RN, Zangwill L, Strack S, Ju WK. PMID: 32312949.
      View in: PubMed   Mentions:    Fields:    
    4. Mitochondrial morphology provides a mechanism for energy buffering at synapses. Sci Rep. 2019 12 04; 9(1):18306. Garcia GC, Bartol TM, Phan S, Bushong EA, Perkins G, Sejnowski TJ, Ellisman MH, Skupin A. PMID: 31797946.
      View in: PubMed   Mentions:    Fields:    
    5. Cardiac ischemia-reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIa. Am J Physiol Heart Circ Physiol. 2019 12 01; 317(6):H1231-H1242. Haushalter KJ, Schilling JM, Song Y, Sastri M, Perkins GA, Strack S, Taylor SS, Patel HH. PMID: 31674811.
      View in: PubMed   Mentions:
    6. Nexilin Is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation. Circulation. 2019 07 02; 140(1):55-66. Liu C, Spinozzi S, Chen JY, Fang X, Feng W, Perkins G, Cattaneo P, Guimarães-Camboa N, Dalton ND, Peterson KL, Wu T, Ouyang K, Fu XD, Evans SM, Chen J. PMID: 30982350.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Adipocyte lipolysis affects Perilipin 5 and cristae organization at the cardiac lipid droplet-mitochondrial interface. Sci Rep. 2019 03 18; 9(1):4734. Varghese M, Kimler VA, Ghazi FR, Rathore GK, Perkins GA, Ellisman MH, Granneman JG. PMID: 30894648.
      View in: PubMed   Mentions: 1     Fields:    
    8. CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. J Cell Biol. 2019 01 07; 218(1):206-219. Gilmore-Hall S, Kuo J, Ward JM, Zahra R, Morrison RS, Perkins G, La Spada AR. PMID: 30337352.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line. Biochem Biophys Res Commun. 2018 09 18; 503(4):2690-2697. Shim MS, Kim KY, Noh M, Ko JY, Ahn S, An MA, Iwata T, Perkins GA, Weinreb RN, Ju WK. PMID: 30100066.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission. J Neurosci. 2018 09 19; 38(38):8233-8242. Flippo KH, Gnanasekaran A, Perkins GA, Ajmal A, Merrill RA, Dickey AS, Taylor SS, McKnight GS, Chauhan AK, Usachev YM, Strack S. PMID: 30093535.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    11. Aerobic Exercise Preconception and During Pregnancy Enhances Oxidative Capacity in the Hindlimb Muscles of Mice Offspring. J Strength Cond Res. 2018 May; 32(5):1391-1403. Liu J, Lee I, Feng HZ, Galen SS, Hüttemann PP, Perkins GA, Jin JP, Hüttemann M, Malek MH. PMID: 29309390.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Mitochondrial dysfunction in iPSC-derived neurons of subjects with chronic mountain sickness. J Appl Physiol (1985). 2018 09 01; 125(3):832-840. Zhao H, Perkins G, Yao H, Callacondo D, Appenzeller O, Ellisman M, La Spada AR, Haddad GG. PMID: 29357502.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50. J Cell Sci. 2017 Oct 01; 130(19):3248-3260. Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor SS, Perkins GA. PMID: 28808085.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. J Cell Biol. 2017 08 07; 216(8):2315-2327. Koehler CL, Perkins GA, Ellisman MH, Jones DL. PMID: 28663346.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. Hypoxia-inducible factor-1a activation improves renal oxygenation and mitochondrial function in early chronic kidney disease. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F282-F290. Thomas JL, Pham H, Li Y, Hall E, Perkins GA, Ali SS, Patel HH, Singh P. PMID: 28331062.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Corrigendum: Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2017 01 19; 7:40460. Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju WK. PMID: 28102236.
      View in: PubMed   Mentions:    Fields:    
    17. Proteolipid protein-deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling. J Cell Biol. 2016 Nov 21; 215(4):531-542. Yin X, Kidd GJ, Ohno N, Perkins GA, Ellisman MH, Bastian C, Brunet S, Baltan S, Trapp BD. PMID: 27872255.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    18. Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration. Sci Rep. 2016 Sep 22; 6:33830. Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju WK. PMID: 27654856.
      View in: PubMed   Mentions: 15     Fields:    
    19. Beneficial effects of dark chocolate on exercise capacity in sedentary subjects: underlying mechanisms. A double blind, randomized, placebo controlled trial. Food Funct. 2016 Sep 14; 7(9):3686-93. Taub PR, Ramirez-Sanchez I, Patel M, Higginbotham E, Moreno-Ulloa A, Román-Pintos LM, Phillips P, Perkins G, Ceballos G, Villarreal F. PMID: 27491778.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    20. A validated active contour method driven by parabolic arc model for detection and segmentation of mitochondria. J Struct Biol. 2016 06; 194(3):253-71. Tasel SF, Mumcuoglu EU, Hassanpour RZ, Perkins G. PMID: 26956730.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. Erratum to: Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo. Cell Tissue Res. 2016 Mar; 363(3):823. Pasqua T, Mahata S, Bandyopadhyay GK, Biswas A, Perkins GA, Sinha-Hikim AP, Goldstein DS, Eiden LE, Mahata SK. PMID: 26809511.
      View in: PubMed   Mentions:    Fields:    
    22. NF-?B Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. PMID: 26919428.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    23. Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1. J Biol Chem. 2016 Mar 11; 291(11):5788-802. Rubio-Marrero EN, Vincelli G, Jeffries CM, Shaikh TR, Pakos IS, Ranaivoson FM, von Daake S, Demeler B, De Jaco A, Perkins G, Ellisman MH, Trewhella J, Comoletti D. PMID: 26721881.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    24. Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo. Cell Tissue Res. 2016 Mar; 363(3):693-712. Pasqua T, Mahata S, Bandyopadhyay GK, Biswas A, Perkins GA, Sinha-Hikim AP, Goldstein DS, Eiden LE, Mahata SK. PMID: 26572539.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    25. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. PMID: 26203188.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Resolving presynaptic structure by electron tomography. Synapse. 2015 May; 69(5):268-82. Perkins GA, Jackson DR, Spirou GA. PMID: 25683026.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    27. Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes. Glia. 2015 May; 63(5):736-53. Ju WK, Kim KY, Noh YH, Hoshijima M, Lukas TJ, Ellisman MH, Weinreb RN, Perkins GA. PMID: 25557093.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    28. Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function. Int J Cardiol. 2014 Aug 01; 175(2):297-306. Yamazaki KG, Andreyev AY, Ortiz-Vilchis P, Petrosyan S, Divakaruni AS, Wiley SE, De La Fuente C, Perkins G, Ceballos G, Villarreal F, Murphy AN. PMID: 24908200.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    29. The use of miniSOG in the localization of mitochondrial proteins. Methods Enzymol. 2014; 547:165-79. Perkins GA. PMID: 25416358.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    30. Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa. Clin Sci (Lond). 2013 Oct; 125(8):383-9. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Gonzalez-Basurto S, Coral-Vazquez R, Perkins G, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. PMID: 23642227.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    31. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. PMID: 24091324.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    32. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor SS. PMID: 24030101.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    33. Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. PLoS One. 2013; 8(9):e74011. Yin S, Xue J, Sun H, Wen B, Wang Q, Perkins G, Zhao HW, Ellisman MH, Hsiao YH, Yin L, Xie Y, Hou G, Zi J, Lin L, Haddad GG, Zhou D, Liu S. PMID: 24069262.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    34. (-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients. Int J Cardiol. 2013 Oct 09; 168(4):3982-3990. Ramirez-Sanchez I, Taub PR, Ciaraldi TP, Nogueira L, Coe T, Perkins G, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. PMID: 23870648.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCTClinical Trials
    35. (-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity. Clin Sci (Lond). 2013 Jun; 124(11):663-74. Hüttemann M, Lee I, Perkins GA, Britton SL, Koch LG, Malek MH. PMID: 23252598.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    36. Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med. 2013 Jun; 5(6):904-18. Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN. PMID: 23703906.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    37. The fractalkine/CX3CR1 system regulates ß cell function and insulin secretion. Cell. 2013 Apr 11; 153(2):413-25. Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. PMID: 23582329.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    38. DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress. PLoS One. 2013; 8(4):e60804. Pamenter ME, Perkins GA, Gu XQ, Ellisman MH, Haddad GG. PMID: 23577164.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    39. Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption. Mol Vis. 2012; 18:3029-48. Perkins GA, Scott R, Perez A, Ellisman MH, Johnson JE, Fox DA. PMID: 23288995.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    40. Autophagy and apoptosis are differentially induced in neurons and astrocytes treated with an in vitro mimic of the ischemic penumbra. PLoS One. 2012; 7(12):e51469. Pamenter ME, Perkins GA, McGinness AK, Gu XQ, Ellisman MH, Haddad GG. PMID: 23251543.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    41. Ceramide and its transport protein (CERT) contribute to deterioration of mitochondrial structure and function in aging oocytes. Mech Ageing Dev. 2013 Jan-Feb; 134(1-2):43-52. Kujjo LL, Acton BM, Perkins GA, Ellisman MH, D'Estaing SG, Casper RF, Jurisicova A, Perez GI. PMID: 23246342.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    42. Stimulatory effects of the flavanol (-)-epicatechin on cardiac angiogenesis: additive effects with exercise. J Cardiovasc Pharmacol. 2012 Nov; 60(5):429-38. Ramirez-Sanchez I, Nogueira L, Moreno A, Murphy A, Taub P, Perkins G, Ceballos GM, Hogan M, Malek M, Villarreal F. PMID: 22833114.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    43. Ultrastructural modifications in the mitochondria of hypoxia-adapted Drosophila melanogaster. PLoS One. 2012; 7(9):e45344. Perkins G, Hsiao YH, Yin S, Tjong J, Tran MT, Lau J, Xue J, Liu S, Ellisman MH, Zhou D. PMID: 23028948.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    44. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. PMID: 22958918.
      View in: PubMed   Mentions: 84     Fields:    Translation:Animals
    45. DIDS prevents ischemic membrane degradation in cultured hippocampal neurons by inhibiting matrix metalloproteinase release. PLoS One. 2012; 7(8):e43995. Pamenter ME, Ryu J, Hua ST, Perkins GA, Mendiola VL, Gu XQ, Ellisman MH, Haddad GG. PMID: 22937143.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    46. Striated organelle, a cytoskeletal structure positioned to modulate hair-cell transduction. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4473-8. Vranceanu F, Perkins GA, Terada M, Chidavaenzi RL, Ellisman MH, Lysakowski A. PMID: 22396594.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    47. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci. 2012 Feb; 5(1):43-7. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Perkins G, Murphy AN, Naviaux R, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. PMID: 22376256.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    48. Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy. PLoS One. 2011; 6(9):e24102. Yamaguchi R, Janssen E, Perkins G, Ellisman M, Kitada S, Reed JC. PMID: 21949692.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    49. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15; 589(Pt 18):4615-31. Nogueira L, Ramirez-Sanchez I, Perkins GA, Murphy A, Taub PR, Ceballos G, Villarreal FJ, Hogan MC, Malek MH. PMID: 21788351.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    50. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011 Jun 08; 13(6):690-700. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. PMID: 21641550.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    51. Isoform-specific targeting of PKA to multivesicular bodies. J Cell Biol. 2011 Apr 18; 193(2):347-63. Day ME, Gaietta GM, Sastri M, Koller A, Mackey MR, Scott JD, Perkins GA, Ellisman MH, Taylor SS. PMID: 21502359.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    52. Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nat Med. 2011 Mar; 17(3):377-82. Song W, Chen J, Petrilli A, Liot G, Klinglmayr E, Zhou Y, Poquiz P, Tjong J, Pouladi MA, Hayden MR, Masliah E, Ellisman M, Rouiller I, Schwarzenbacher R, Bossy B, Perkins G, Bossy-Wetzel E. PMID: 21336284.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    53. Mitochondrial rejuvenation after induced pluripotency. PLoS One. 2010 Nov 23; 5(11):e14095. Suhr ST, Chang EA, Tjong J, Alcasid N, Perkins GA, Goissis MD, Ellisman MH, Perez GI, Cibelli JB. PMID: 21124794.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    54. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem. 2011 Jan 28; 286(4):2918-32. Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA, Ellisman MH, Taylor SS. PMID: 21081504.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    55. Mitochondrial configurations in peripheral nerve suggest differential ATP production. J Struct Biol. 2011 Jan; 173(1):117-27. Perkins GA, Ellisman MH. PMID: 20600951.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    56. A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9861-6. Kim CE, Perez A, Perkins G, Ellisman MH, Dauer WT. PMID: 20457914.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    57. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 05; 327(5970):1223-8. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. PMID: 20203043.
      View in: PubMed   Mentions: 200     Fields:    Translation:AnimalsCells
    58. The micro-architecture of mitochondria at active zones: electron tomography reveals novel anchoring scaffolds and cristae structured for high-rate metabolism. J Neurosci. 2010 Jan 20; 30(3):1015-26. Perkins GA, Tjong J, Brown JM, Poquiz PH, Scott RT, Kolson DR, Ellisman MH, Spirou GA. PMID: 20089910.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    59. New insights into mitochondrial structure during cell death. Exp Neurol. 2009 Aug; 218(2):183-92. Perkins G, Bossy-Wetzel E, Ellisman MH. PMID: 19464290.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    60. Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1. Biochim Biophys Acta. 2009 Aug; 1787(8):963-72. Yamaguchi R, Perkins G. PMID: 19245786.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    61. Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Mol Vis. 2009; 15:120-34. Ju WK, Kim KY, Lindsey JD, Angert M, Patel A, Scott RT, Liu Q, Crowston JG, Ellisman MH, Perkins GA, Weinreb RN. PMID: 19169378.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    62. Chapter 2 Correlated light and electron microscopy/electron tomography of mitochondria in situ. Methods Enzymol. 2009; 456:29-52. Perkins GA, Sun MG, Frey TG. PMID: 19348881.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    63. Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization. Mol Cell. 2008 Aug 22; 31(4):557-69. Yamaguchi R, Lartigue L, Perkins G, Scott RT, Dixit A, Kushnareva Y, Kuwana T, Ellisman MH, Newmeyer DD. PMID: 18691924.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    64. Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci. 2008 Jul; 9(7):505-18. Knott AB, Perkins G, Schwarzenbacher R, Bossy-Wetzel E. PMID: 18568013.
      View in: PubMed   Mentions: 331     Fields:    Translation:HumansAnimalsCells
    65. Clearing the brain's cobwebs: the role of autophagy in neuroprotection. Curr Neuropharmacol. 2008 Jun; 6(2):97-101. Bossy B, Perkins G, Bossy-Wetzel E. PMID: 19305790.
      View in: PubMed   Mentions: 6     Fields:    
    66. Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4903-11. Ju WK, Kim KY, Lindsey JD, Angert M, Duong-Polk KX, Scott RT, Kim JJ, Kukhmazov I, Ellisman MH, Perkins GA, Weinreb RN. PMID: 18469184.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    67. An adenoviral platform for selective self-assembly and targeted delivery of nanoparticles. Small. 2008 Feb; 4(2):262-9. Saini V, Martyshkin DV, Mirov SB, Perez A, Perkins G, Ellisman MH, Towner VD, Wu H, Pereboeva L, Borovjagin A, Curiel DT, Everts M. PMID: 18200644.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    68. Electron tomographic analysis of cytoskeletal cross-bridges in the paranodal region of the node of Ranvier in peripheral nerves. J Struct Biol. 2008 Mar; 161(3):469-80. Perkins GA, Sosinsky GE, Ghassemzadeh S, Perez A, Jones Y, Ellisman MH. PMID: 18096402.
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    69. Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol. 2007 Nov; 27(21):7522-37. Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, Dalton ND, Thor AK, Perkins GA, McCulloch AD, Ross RS. PMID: 17785437.
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    70. Three-dimensional analysis of a viral RNA replication complex reveals a virus-induced mini-organelle. PLoS Biol. 2007 Sep; 5(9):e220. Kopek BG, Perkins G, Miller DJ, Ellisman MH, Ahlquist P. PMID: 17696647.
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    71. Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis. Nat Cell Biol. 2007 Sep; 9(9):1057-65. Sun MG, Williams J, Munoz-Pinedo C, Perkins GA, Brown JM, Ellisman MH, Green DR, Frey TG. PMID: 17721514.
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    72. BUB1 mediation of caspase-independent mitotic death determines cell fate. J Cell Biol. 2007 Jul 16; 178(2):283-96. Niikura Y, Dixit A, Scott R, Perkins G, Kitagawa K. PMID: 17620410.
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    73. Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses. Mol Vis. 2007 Jun 15; 13:887-919. Johnson JE, Perkins GA, Giddabasappa A, Chaney S, Xiao W, White AD, Brown JM, Waggoner J, Ellisman MH, Fox DA. PMID: 17653034.
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    74. Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wrist. Cell. 2007 May 04; 129(3):579-91. Bielas SL, Serneo FF, Chechlacz M, Deerinck TJ, Perkins GA, Allen PB, Ellisman MH, Gleeson JG. PMID: 17482550.
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    75. Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2145-51. Ju WK, Liu Q, Kim KY, Crowston JG, Lindsey JD, Agarwal N, Ellisman MH, Perkins GA, Weinreb RN. PMID: 17460273.
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    76. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J. 2006 Aug 23; 25(16):3900-11. Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gräber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, Ellisman MH, Perkins GA, Bossy-Wetzel E. PMID: 16874299.
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    77. Collaborative development of the Arrowsmith two node search interface designed for laboratory investigators. J Biomed Discov Collab. 2006 Jul 03; 1:8. Smalheiser NR, Torvik VI, Bischoff-Grethe A, Burhans LB, Gabriel M, Homayouni R, Kashef A, Martone ME, Perkins GA, Price DL, Talk AC, West R. PMID: 16817965.
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    78. Covalently linked Au nanoparticles to a viral vector: potential for combined photothermal and gene cancer therapy. . 2006 Apr; 6(4):587-91. Everts M, Saini V, Leddon JL, Kok RJ, Stoff-Khalili M, Preuss MA, Millican CL, Perkins G, Brown JM, Bagaria H, Nikles DE, Johnson DT, Zharov VP, Curiel DT. PMID: 16608249.
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    79. Transform-based backprojection for volume reconstruction of large format electron microscope tilt series. J Struct Biol. 2006 May; 154(2):144-67. Lawrence A, Bouwer JC, Perkins G, Ellisman MH. PMID: 16542854.
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    80. Electron tomography of membrane-bound cellular organelles. Annu Rev Biophys Biomol Struct. 2006; 35:199-224. Frey TG, Perkins GA, Ellisman MH. PMID: 16689634.
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    81. Guidelines for negotiating scientific collaboration. PLoS Biol. 2005 Jun; 3(6):e217. Smalheiser NR, Perkins GA, Jones S. PMID: 15941361.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    82. The structure-function correlates of mammalian rod and cone photoreceptor mitochondria: observations and unanswered questions. Mitochondrion. 2004 Sep; 4(5-6):695-703. Perkins GA, Ellisman MH, Fox DA. PMID: 16120425.
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    83. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell. 2004 Jun 11; 117(6):773-86. Ricci JE, Muñoz-Pinedo C, Fitzgerald P, Bailly-Maitre B, Perkins GA, Yadava N, Scheffler IE, Ellisman MH, Green DR. PMID: 15186778.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    84. Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron. 2004 Feb 05; 41(3):351-65. Bossy-Wetzel E, Talantova MV, Lee WD, Schölzke MN, Harrop A, Mathews E, Götz T, Han J, Ellisman MH, Perkins GA, Lipton SA. PMID: 14766175.
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    85. Three-dimensional analysis of mouse rod and cone mitochondrial cristae architecture: bioenergetic and functional implications. Mol Vis. 2003 Mar 11; 9:60-73. Perkins GA, Ellisman MH, Fox DA. PMID: 12632036.
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    86. Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1022-7. He L, Perkins GA, Poblenz AT, Harris JB, Hung M, Ellisman MH, Fox DA. PMID: 12540825.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    87. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell. 2002 Nov 01; 111(3):331-42. Kuwana T, Mackey MR, Perkins G, Ellisman MH, Latterich M, Schneiter R, Green DR, Newmeyer DD. PMID: 12419244.
      View in: PubMed   Mentions: 427     Fields:    Translation:HumansAnimalsCells
    88. A thermodynamic model describing the nature of the crista junction: a structural motif in the mitochondrion. J Struct Biol. 2002 Apr-May; 138(1-2):137-44. Renken C, Siragusa G, Perkins G, Washington L, Nulton J, Salamon P, Frey TG. PMID: 12160710.
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