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Robert Mak

Title(s)Professor, Pediatrics
SchoolHealth Sciences
Phone858-822-6717
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Oliveira EA, Zheng R, Carter CE, Mak RH. Cachexia/Protein energy wasting syndrome in CKD: Causation and treatment. Semin Dial. 2019 Jul 08. PMID: 31286575.
      View in: PubMed
    2. Vasconcelos MA, Oliveira EA, Simões E Silva AC, Dias CS, Mak RH, Fonseca CC, Campos APM, Steyerberg EW, Vergouwe Y. A Predictive Model of Postnatal Surgical Intervention in Children With Prenatally Detected Congenital Anomalies of the Kidney and Urinary Tract. Front Pediatr. 2019; 7:120. PMID: 31001505.
      View in: PubMed
    3. Lobry T, Miller R, Nevo N, Rocca CJ, Zhang J, Catz SD, Moore F, Thomas L, Pouly D, Bailleux A, Guerrera IC, Gubler MC, Cheung WW, Mak RH, Montier T, Antignac C, Cherqui S. Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis. Kidney Int. 2019 Mar 06. PMID: 30928021.
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    4. Poggiali IV, Simões E Silva AC, Vasconcelos MA, Dias CS, Gomes IR, Carvalho RA, Oliveira MCL, Pinheiro SV, Mak RH, Oliveira EA. A clinical predictive model of renal injury in children with congenital solitary functioning kidney. Pediatr Nephrol. 2019 Mar; 34(3):465-474. PMID: 30324507.
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    5. Vasconcelos MA, E Silva ACS, Gomes IR, Carvalho RA, Pinheiro SV, Colosimo EA, Yorgin P, Mak RH, Oliveira EA. A clinical predictive model of chronic kidney disease in children with posterior urethral valves. Pediatr Nephrol. 2019 Feb; 34(2):283-294. PMID: 30196383.
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    6. Oliveira EA, Mak RH. Progression of chronic kidney disease in children - role of glomerular hemodynamics and interstitial fibrosis. Curr Opin Pediatr. 2018 04; 30(2):220-227. PMID: 29389683.
      View in: PubMed
    7. Wang Z, Oliveira EA, Mak RH. Unacylated ghrelin and obestatin in pediatric CKD: are they important in protein energy wasting? Pediatr Nephrol. 2018 May; 33(5):741-743. PMID: 29453692.
      View in: PubMed
    8. Mak RH, Cheung WW, Solomon G, Gertler A. Preparation of Potent Leptin Receptor Antagonists and Their Therapeutic Use in Mouse Models of Uremic Cachexia and Kidney Fibrosis. Curr Pharm Des. 2018; 24(9):1012-1018. PMID: 29366406.
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    9. Ku E, Kopple JD, McCulloch CE, Warady BA, Furth SL, Mak RH, Grimes BA, Mitsnefes M. Associations Between Weight Loss, Kidney Function Decline, and Risk of ESRD in the Chronic Kidney Disease in Children (CKiD) Cohort Study. Am J Kidney Dis. 2018 May; 71(5):648-656. PMID: 29132947.
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    10. Cheung WW, Hao S, Mak RH. Emerging roles of nuclear phosphatase SCP4 in CKD-associated muscle wasting. Kidney Int. 2017 08; 92(2):281-283. PMID: 28709594.
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    11. Mak RH, Cheung WW. MicroRNA as Novel Exercise Mimetic for Muscle Wasting in CKD. J Am Soc Nephrol. 2017 09; 28(9):2557-2559. PMID: 28720683.
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    12. Fuhrman DY, Schneider MF, Dell KM, Blydt-Hansen TD, Mak R, Saland JM, Furth SL, Warady BA, Moxey-Mims MM, Schwartz GJ. Albuminuria, Proteinuria, and Renal Disease Progression in Children with CKD. Clin J Am Soc Nephrol. 2017 Jun 07; 12(6):912-920. PMID: 28546440.
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    13. Oliveira EA, Cheung WW, Toma KG, Mak RH. Muscle wasting in chronic kidney disease. Pediatr Nephrol. 2018 May; 33(5):789-798. PMID: 28508131.
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    14. Nourbakhsh N, Mak RH. Steroid-resistant nephrotic syndrome: past and current perspectives. Pediatric Health Med Ther. 2017; 8:29-37. PMID: 29388620.
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    15. Mak RH. Cachexia in children with chronic kidney disease: challenges in diagnosis and treatment. Curr Opin Support Palliat Care. 2016 12; 10(4):293-297. PMID: 27258684.
      View in: PubMed
    16. Tu J, Cheung WW, Mak RH. Inflammation and nutrition in children with chronic kidney disease. World J Nephrol. 2016 May 06; 5(3):274-82. PMID: 27152263; PMCID: PMC4848150.
    17. Oliveira EA, Oliveira MC, Mak RH. Evaluation and management of hydronephrosis in the neonate. Curr Opin Pediatr. 2016 Apr; 28(2):195-201. PMID: 26807623.
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    18. Floege J, Mak RH, Molitoris BA, Remuzzi G, Ronco P. Nephrology research--the past, present and future. Nat Rev Nephrol. 2015 11; 11(11):677-87. PMID: 26416499.
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    19. Cheung WW, Cherqui S, Ding W, Esparza M, Zhou P, Shao J, Lieber RL, Mak RH. Muscle wasting and adipose tissue browning in infantile nephropathic cystinosis. J Cachexia Sarcopenia Muscle. 2016 05; 7(2):152-64. PMID: 27493869.
      View in: PubMed
    20. Mak RH, Hoffman HM. Transplantation: Outcomes of prenatal immunosuppression. Nat Rev Nephrol. 2015 Jul; 11(7):390-1. PMID: 25986424.
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    21. Ding W, Cheung WW, Mak RH. Impact of obesity on kidney function and blood pressure in children. World J Nephrol. 2015 May 06; 4(2):223-9. PMID: 25949935; PMCID: PMC4419131.
    22. Warady BA, Abraham AG, Schwartz GJ, Wong CS, Muñoz A, Betoko A, Mitsnefes M, Kaskel F, Greenbaum LA, Mak RH, Flynn J, Moxey-Mims MM, Furth S. Predictors of Rapid Progression of Glomerular and Nonglomerular Kidney Disease in Children and Adolescents: The Chronic Kidney Disease in Children (CKiD) Cohort. Am J Kidney Dis. 2015 Jun; 65(6):878-88. PMID: 25799137; PMCID: PMC4578873.
    23. Lemley KV, Mak RH. Nephrotic syndrome: Efficacy of rituximab in challenging nephrotic syndrome. Nat Rev Nephrol. 2015 May; 11(5):257-8. PMID: 25752834.
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    24. Mak RH, Cheung WW, Gertler A. Exploiting the therapeutic potential of leptin signaling in cachexia. Curr Opin Support Palliat Care. 2014 Dec; 8(4):352-7. PMID: 25259544.
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    25. Ding W, Mak RH. Early markers of obesity-related renal injury in childhood. Pediatr Nephrol. 2015 Jan; 30(1):1-4. PMID: 25322907.
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    26. Mak RH, Schaefer F. Chronic kidney disease: Prenatal risk factors for kidney and urinary tract anomalies. Nat Rev Nephrol. 2014 Aug; 10(8):428-9. PMID: 24935706.
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    27. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. PMID: 24691027; PMCID: PMC4025063.
    28. Ingulli EG, Mak RH. Growth in children with chronic kidney disease: role of nutrition, growth hormone, dialysis, and steroids. Curr Opin Pediatr. 2014 Apr; 26(2):187-92. PMID: 24535500.
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    29. Abraham AG, Mak RH, Mitsnefes M, White C, Moxey-Mims M, Warady B, Furth SL. Protein energy wasting in children with chronic kidney disease. Pediatr Nephrol. 2014 Jul; 29(7):1231-8. PMID: 24504731; PMCID: PMC4414488.
    30. Cheung WW, Ding W, Gunta SS, Gu Y, Tabakman R, Klapper LN, Gertler A, Mak RH. A pegylated leptin antagonist ameliorates CKD-associated cachexia in mice. J Am Soc Nephrol. 2014 Jan; 25(1):119-28. PMID: 24115476; PMCID: PMC3871780.
    31. Mak RH, Smoyer WE. Nephrotic syndrome: Genetic screening in steroid-resistant nephrotic syndrome. Nat Rev Nephrol. 2013 Jul; 9(7):379-81. PMID: 23689120.
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    32. Gunta SS, Thadhani RI, Mak RH. The effect of vitamin D status on risk factors for cardiovascular disease. Nat Rev Nephrol. 2013 Jun; 9(6):337-47. PMID: 23609564.
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    33. Gunta SS, Mak RH. Ghrelin and leptin pathophysiology in chronic kidney disease. Pediatr Nephrol. 2013 Apr; 28(4):611-6. PMID: 23229444.
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    34. Mak RH, Warady BA. Dialysis: Vascular access in children--arteriovenous fistula or CVC? Nat Rev Nephrol. 2013 Jan; 9(1):9-11. PMID: 23183841.
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    35. Gunta SS, Mak RH. Is obesity a risk factor for chronic kidney disease in children? Pediatr Nephrol. 2013 Oct; 28(10):1949-56. PMID: 23150030.
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    36. Carter CE, Shayan K, Mak RH, Yorgin PD, Krous HF. Nephrotic syndrome in an 18-year-old boy with congenital myelomeningocele: questions. Pediatr Nephrol. 2013 Oct; 28(10):1963-4, 1965-7. PMID: 23135608.
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    37. Cheung WW, Mak RH. Melanocortin antagonism ameliorates muscle wasting and inflammation in chronic kidney disease. Am J Physiol Renal Physiol. 2012 Nov 01; 303(9):F1315-24. PMID: 22914778; PMCID: PMC3518185.
    38. Mak RH, Cheung WW. MicroRNAs: a new therapeutic frontier for muscle wasting in chronic kidney disease. Kidney Int. 2012 Aug; 82(4):373-4. PMID: 22846810.
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    39. Mak RH. Serum myostatin in patients on maintenance haemodialysis: a useful biomarker of muscle wasting?. Clin Endocrinol (Oxf). 2011 Dec; 75(6):738-9. PMID: 21913953.
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    40. Rees L, Mak RH. Nutrition and growth in children with chronic kidney disease. Nat Rev Nephrol. 2011 Sep 27; 7(11):615-23. PMID: 21947116.
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    41. Foster BJ, McCauley L, Mak RH. Nutrition in infants and very young children with chronic kidney disease. Pediatr Nephrol. 2012 Sep; 27(9):1427-39. PMID: 21874586.
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    42. Furth SL, Abraham AG, Jerry-Fluker J, Schwartz GJ, Benfield M, Kaskel F, Wong C, Mak RH, Moxey-Mims M, Warady BA. Metabolic abnormalities, cardiovascular disease risk factors, and GFR decline in children with chronic kidney disease. Clin J Am Soc Nephrol. 2011 Sep; 6(9):2132-40. PMID: 21841064; PMCID: PMC3358991.
    43. Mak RH, Ikizler TA, Kovesdy CP, Raj DS, Stenvinkel P, Kalantar-Zadeh K. Erratum to: Wasting in chronic kidney disease. J Cachexia Sarcopenia Muscle. 2011 Jun; 2(2):119. PMID: 22477651; PMCID: PMC3117998.
    44. Kalantar-Zadeh K, Cano NJ, Budde K, Chazot C, Kovesdy CP, Mak RH, Mehrotra R, Raj DS, Sehgal AR, Stenvinkel P, Ikizler TA. Diets and enteral supplements for improving outcomes in chronic kidney disease. Nat Rev Nephrol. 2011 May 31; 7(7):369-84. PMID: 21629229; PMCID: PMC3876473.
    45. Ishikura K, Hamasaki Y, Sakai T, Hataya H, Mak RH, Honda M. Posterior reversible encephalopathy syndrome in children with kidney diseases. Pediatr Nephrol. 2012 Mar; 27(3):375-84. PMID: 21556718.
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    46. Mak RH, Cheung WW. Is ghrelin a biomarker for mortality in end-stage renal disease? Kidney Int. 2011 Apr; 79(7):697-9. PMID: 21403653.
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    47. Mak RH, Ikizler AT, Kovesdy CP, Raj DS, Stenvinkel P, Kalantar-Zadeh K. Wasting in chronic kidney disease. J Cachexia Sarcopenia Muscle. 2011 Mar; 2(1):9-25. PMID: 21475675.
      View in: PubMed
    48. Mak RH, Cheung WW, Zhan JY, Shen Q, Foster BJ. Cachexia and protein-energy wasting in children with chronic kidney disease. Pediatr Nephrol. 2012 Feb; 27(2):173-81. PMID: 21298504; PMCID: PMC3249542.
    49. Cheung WW, Zhan JY, Paik KH, Mak RH. The impact of inflammation on bone mass in children. Pediatr Nephrol. 2011 Nov; 26(11):1937-46. PMID: 21197596; PMCID: PMC3178021.
    50. Querfeld U, Mak RH. Vitamin D deficiency and toxicity in chronic kidney disease: in search of the therapeutic window. Pediatr Nephrol. 2010 Dec; 25(12):2413-30. PMID: 20567854.
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    51. Santos F, Kaskel FJ, Mak RH, Caldas A. 8th International Symposium on Growth and Nutrition in Children with Chronic Renal Disease: 28-30 May 2009, Oviedo, Asturias, Spain. Pediatr Nephrol. 2010 Apr; 25(4):581-2. PMID: 20013292; PMCID: PMC2827802.
    52. Cheung WW, Mak RH. Ghrelin in chronic kidney disease. Int J Pept. 2010; 2010. PMID: 20721357; PMCID: PMC2915808.
    53. Mak RH, Bakris G. Pediatrics: Masked hypertension: a risk factor in children with CKD. Nat Rev Nephrol. 2010 Mar; 6(3):132-4. PMID: 20186228.
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    54. Mak RH, Flynn J, Bakris G. Pediatrics: blood pressure target for renoprotection in children. Nat Rev Nephrol. 2010 Feb; 6(2):67-8. PMID: 20111045.
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    55. Cheung WW, Paik KH, Mak RH. Inflammation and cachexia in chronic kidney disease. Pediatr Nephrol. 2010 Apr; 25(4):711-24. PMID: 20111974.
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    56. Cheung WW, Mak RH. Ghrelin and its analogues as therapeutic agents for anorexia and cachexia in end-stage renal disease. Kidney Int. 2009 Jul; 76(2):135-7. PMID: 19564855.
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    57. Wong CS, Pierce CB, Cole SR, Warady BA, Mak RH, Benador NM, Kaskel F, Furth SL, Schwartz GJ. Association of proteinuria with race, cause of chronic kidney disease, and glomerular filtration rate in the chronic kidney disease in children study. Clin J Am Soc Nephrol. 2009 Apr; 4(4):812-9. PMID: 19297612; PMCID: PMC2666424.
    58. Mak RH. Recent advances in chronic dialysis and renal transplantation in children. Pediatr Nephrol. 2009 Mar; 24(3):459-61. PMID: 19153772.
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    59. Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009 Mar; 20(3):629-37. PMID: 19158356; PMCID: PMC2653687.
    60. Mak RH. Acute kidney injury in children: the dawn of a new era. Pediatr Nephrol. 2008 Dec; 23(12):2147-9. PMID: 18936981.
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    61. Cheung WW, Rosengren S, Boyle DL, Mak RH. Modulation of melanocortin signaling ameliorates uremic cachexia. Kidney Int. 2008 Jul; 74(2):180-6. PMID: 18432186.
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    62. Mak RH, Cheung W. Therapeutic strategy for cachexia in chronic kidney disease. Curr Opin Nephrol Hypertens. 2007 Nov; 16(6):542-6. PMID: 18089968.
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    63. Mak RH, Wong JH. Are oral antibiotics alone efficacious for the treatment of a first episode of acute pyelonephritis in children? Nat Clin Pract Nephrol. 2008 Jan; 4(1):10-1. PMID: 17971799.
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    64. Mak RH. Insulin and its role in chronic kidney disease. Pediatr Nephrol. 2008 Mar; 23(3):355-62. PMID: 17929061.
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    65. Mak RH, Cheung WW, Roberts CT. The growth hormone-insulin-like growth factor-I axis in chronic kidney disease. Growth Horm IGF Res. 2008 Feb; 18(1):17-25. PMID: 17826224; PMCID: PMC2706146.
    66. Cheung WW, Kuo HJ, Markison S, Chen C, Foster AC, Marks DL, Mak RH. Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice. J Am Soc Nephrol. 2007 Sep; 18(9):2517-24. PMID: 17687077.
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    67. Mak RH, Cheung W. Adipokines and gut hormones in end-stage renal disease. Perit Dial Int. 2007 Jun; 27 Suppl 2:S298-302. PMID: 17556323.
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    68. Wahba IM, Mak RH. Obesity and obesity-initiated metabolic syndrome: mechanistic links to chronic kidney disease. Clin J Am Soc Nephrol. 2007 May; 2(3):550-62. PMID: 17699463.
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    69. Mak RH, Cheung W. Cachexia in chronic kidney disease: role of inflammation and neuropeptide signaling. Curr Opin Nephrol Hypertens. 2007 Jan; 16(1):27-31. PMID: 17143068.
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    70. Mak RH, Cheung W, Purnell J. Ghrelin in chronic kidney disease: too much or too little? Perit Dial Int. 2007 Jan-Feb; 27(1):51-5. PMID: 17179511.
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    71. Mak RH, Proesmans W, Trachtman H. Teaching articles: a new goal of the journal. Pediatr Nephrol. 2007 Jan; 22(1):24-5. PMID: 17086404.
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    72. Mak RH. Chronic kidney disease in children: state of the art. Pediatr Nephrol. 2007 Oct; 22(10):1687-8. PMID: 17086403.
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    73. Mak RH. Can plasma iohexol disappearance be used to measure GFR in children with chronic kidney disease? Nat Clin Pract Nephrol. 2006 Nov; 2(11):608-9. PMID: 17066046.
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    74. Mak RH, Kuo HJ, Cheung WW. Animal models of obesity-associated chronic kidney disease. Adv Chronic Kidney Dis. 2006 Oct; 13(4):374-85. PMID: 17045223.
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    75. Mak RH, Cheung W, Cone RD, Marks DL. Mechanisms of disease: Cytokine and adipokine signaling in uremic cachexia. Nat Clin Pract Nephrol. 2006 Sep; 2(9):527-34. PMID: 16941045.
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    76. Mak RH, Cheung W. Energy homeostasis and cachexia in chronic kidney disease. Pediatr Nephrol. 2006 Dec; 21(12):1807-14. PMID: 16897005.
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    77. Furth SL, Cole SR, Moxey-Mims M, Kaskel F, Mak R, Schwartz G, Wong C, Muñoz A, Warady BA. Design and methods of the Chronic Kidney Disease in Children (CKiD) prospective cohort study. Clin J Am Soc Nephrol. 2006 Sep; 1(5):1006-15. PMID: 17699320; PMCID: PMC3630231.
    78. Mak RH, Kuo HJ. Pathogenesis of urinary tract infection: an update. Curr Opin Pediatr. 2006 Apr; 18(2):148-52. PMID: 16601494.
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    79. Cheung W, Yu PX, Little BM, Cone RD, Marks DL, Mak RH. Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest. 2005 Jun; 115(6):1659-65. PMID: 15931394; PMCID: PMC1136984.
    80. Mak RH, Cheung W, Cone RD, Marks DL. Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease. Pediatr Nephrol. 2005 Mar; 20(3):427-31. PMID: 15662537.
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    81. Mak RH, Chang SL, Pak YK. Growth impairment of primary chondrocyte cells by serum of rats with chronic renal failure. Exp Mol Med. 2004 Jun 30; 36(3):243-50. PMID: 15272236.
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    82. Mak RH, Chang SL, Draksharapu A, Pak YK. Gene expression in uremic left ventricular hypertrophy: effects of hypertension and anemia. Exp Mol Med. 2004 Jun 30; 36(3):251-8. PMID: 15272237.
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    83. Mak RH, Kuo HJ. Primary ureteral reflux: emerging insights from molecular and genetic studies. Curr Opin Pediatr. 2003 Apr; 15(2):181-5. PMID: 12640275.
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