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Robert Mak

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address9500 Gilman Drive #0630
La Jolla CA 92093
Phone858-822-6717
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Oliveira EA, Mak R. Progression of chronic kidney disease in children - role of glomerular hemodynamics and interstitial fibrosis. Curr Opin Pediatr. 2018 Apr; 30(2):220-227. PMID: 29389683.
      View in: PubMed
    2. Wang Z, Oliveira EA, Mak R. Unacylated ghrelin and obestatin in pediatric CKD: are they important in protein energy wasting? Pediatr Nephrol. 2018 May; 33(5):741-743. PMID: 29453692.
      View in: PubMed
    3. Mak R, Cheung WW, Solomon G, Gertler A. Preparation of Potent Leptin Receptor Antagonists and Their Therapeutic Use in Mouse Models of Uremic Cachexia and Kidney Fibrosis. Curr Pharm Des. 2018; 24(9):1012-1018. PMID: 29366406.
      View in: PubMed
    4. Ku E, Kopple JD, McCulloch CE, Warady BA, Furth SL, Mak R, Grimes BA, Mitsnefes M. Associations Between Weight Loss, Kidney Function Decline, and Risk of ESRD in the Chronic Kidney Disease in Children (CKiD) Cohort Study. Am J Kidney Dis. 2018 May; 71(5):648-656. PMID: 29132947.
      View in: PubMed
    5. Cheung WW, Hao S, Mak R. Emerging roles of nuclear phosphatase SCP4 in CKD-associated muscle wasting. Kidney Int. 2017 Aug; 92(2):281-283. PMID: 28709594.
      View in: PubMed
    6. Mak R, Cheung WW. MicroRNA as Novel Exercise Mimetic for Muscle Wasting in CKD. J Am Soc Nephrol. 2017 Sep; 28(9):2557-2559. PMID: 28720683.
      View in: PubMed
    7. Fuhrman DY, Schneider MF, Dell KM, Blydt-Hansen TD, Mak R, Saland JM, Furth SL, Warady BA, Moxey-Mims MM, Schwartz GJ. Albuminuria, Proteinuria, and Renal Disease Progression in Children with CKD. Clin J Am Soc Nephrol. 2017 Jun 07; 12(6):912-920. PMID: 28546440.
      View in: PubMed
    8. Oliveira EA, Cheung WW, Toma KG, Mak R. Muscle wasting in chronic kidney disease. Pediatr Nephrol. 2018 May; 33(5):789-798. PMID: 28508131.
      View in: PubMed
    9. Nourbakhsh N, Mak R. Steroid-resistant nephrotic syndrome: past and current perspectives. Pediatric Health Med Ther. 2017; 8:29-37. PMID: 29388620.
      View in: PubMed
    10. Mak R. Cachexia in children with chronic kidney disease: challenges in diagnosis and treatment. Curr Opin Support Palliat Care. 2016 Dec; 10(4):293-297. PMID: 27258684.
      View in: PubMed
    11. Tu J, Cheung WW, Mak R. Inflammation and nutrition in children with chronic kidney disease. World J Nephrol. 2016 May 06; 5(3):274-82. PMID: 27152263; PMCID: PMC4848150.
    12. Oliveira EA, Oliveira MC, Mak R. Evaluation and management of hydronephrosis in the neonate. Curr Opin Pediatr. 2016 Apr; 28(2):195-201. PMID: 26807623.
      View in: PubMed
    13. Floege J, Mak R, Molitoris BA, Remuzzi G, Ronco P. Nephrology research--the past, present and future. Nat Rev Nephrol. 2015 11; 11(11):677-87. PMID: 26416499.
      View in: PubMed
    14. Cheung WW, Cherqui S, Ding W, Esparza M, Zhou P, Shao J, Lieber RL, Mak R. Muscle wasting and adipose tissue browning in infantile nephropathic cystinosis. J Cachexia Sarcopenia Muscle. 2016 May; 7(2):152-64. PMID: 27493869; PMCID: PMC4864942.
    15. Mak R, Hoffman HM. Transplantation: Outcomes of prenatal immunosuppression. Nat Rev Nephrol. 2015 Jul; 11(7):390-1. PMID: 25986424.
      View in: PubMed
    16. Ding W, Cheung WW, Mak R. Impact of obesity on kidney function and blood pressure in children. World J Nephrol. 2015 May 06; 4(2):223-9. PMID: 25949935; PMCID: PMC4419131.
    17. Warady BA, Abraham AG, Schwartz GJ, Wong CS, Muñoz A, Betoko A, Mitsnefes M, Kaskel F, Greenbaum LA, Mak R, Flynn J, Moxey-Mims MM, Furth S. Predictors of Rapid Progression of Glomerular and Nonglomerular Kidney Disease in Children and Adolescents: The Chronic Kidney Disease in Children (CKiD) Cohort. Am J Kidney Dis. 2015 Jun; 65(6):878-88. PMID: 25799137; PMCID: PMC4578873.
    18. Lemley KV, Mak R. Nephrotic syndrome: Efficacy of rituximab in challenging nephrotic syndrome. Nat Rev Nephrol. 2015 May; 11(5):257-8. PMID: 25752834.
      View in: PubMed
    19. Mak R, Cheung WW, Gertler A. Exploiting the therapeutic potential of leptin signaling in cachexia. Curr Opin Support Palliat Care. 2014 Dec; 8(4):352-7. PMID: 25259544.
      View in: PubMed
    20. Ding W, Mak R. Early markers of obesity-related renal injury in childhood. Pediatr Nephrol. 2015 Jan; 30(1):1-4. PMID: 25322907.
      View in: PubMed
    21. Mak R, Schaefer F. Chronic kidney disease: Prenatal risk factors for kidney and urinary tract anomalies. Nat Rev Nephrol. 2014 Aug; 10(8):428-9. PMID: 24935706.
      View in: PubMed
    22. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. PMID: 24691027; PMCID: PMC4025063.
    23. Ingulli EG, Mak R. Growth in children with chronic kidney disease: role of nutrition, growth hormone, dialysis, and steroids. Curr Opin Pediatr. 2014 Apr; 26(2):187-92. PMID: 24535500.
      View in: PubMed
    24. Abraham AG, Mak R, Mitsnefes M, White C, Moxey-Mims M, Warady B, Furth SL. Protein energy wasting in children with chronic kidney disease. Pediatr Nephrol. 2014 Jul; 29(7):1231-8. PMID: 24504731; PMCID: PMC4414488.
    25. Cheung WW, Ding W, Gunta SS, Gu Y, Tabakman R, Klapper LN, Gertler A, Mak R. A pegylated leptin antagonist ameliorates CKD-associated cachexia in mice. J Am Soc Nephrol. 2014 Jan; 25(1):119-28. PMID: 24115476; PMCID: PMC3871780.
    26. Mak R, Smoyer WE. Nephrotic syndrome: Genetic screening in steroid-resistant nephrotic syndrome. Nat Rev Nephrol. 2013 Jul; 9(7):379-81. PMID: 23689120.
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    27. Gunta SS, Thadhani RI, Mak R. The effect of vitamin D status on risk factors for cardiovascular disease. Nat Rev Nephrol. 2013 Jun; 9(6):337-47. PMID: 23609564.
      View in: PubMed
    28. Gunta SS, Mak R. Ghrelin and leptin pathophysiology in chronic kidney disease. Pediatr Nephrol. 2013 Apr; 28(4):611-6. PMID: 23229444.
      View in: PubMed
    29. Mak R, Warady BA. Dialysis: Vascular access in children--arteriovenous fistula or CVC? Nat Rev Nephrol. 2013 Jan; 9(1):9-11. PMID: 23183841.
      View in: PubMed
    30. Gunta SS, Mak R. Is obesity a risk factor for chronic kidney disease in children? Pediatr Nephrol. 2013 Oct; 28(10):1949-56. PMID: 23150030.
      View in: PubMed
    31. Carter CE, Shayan K, Mak R, Yorgin PD, Krous HF. Nephrotic syndrome in an 18-year-old boy with congenital myelomeningocele: questions. Pediatr Nephrol. 2013 Oct; 28(10):1963-4, 1965-7. PMID: 23135608.
      View in: PubMed
    32. Cheung WW, Mak R. Melanocortin antagonism ameliorates muscle wasting and inflammation in chronic kidney disease. Am J Physiol Renal Physiol. 2012 Nov 01; 303(9):F1315-24. PMID: 22914778; PMCID: PMC3518185.
    33. Mak R, Cheung WW. MicroRNAs: a new therapeutic frontier for muscle wasting in chronic kidney disease. Kidney Int. 2012 Aug; 82(4):373-4. PMID: 22846810.
      View in: PubMed
    34. Mak R. Serum myostatin in patients on maintenance haemodialysis: a useful biomarker of muscle wasting?. Clin Endocrinol (Oxf). 2011 Dec; 75(6):738-9. PMID: 21913953.
      View in: PubMed
    35. Rees L, Mak R. Nutrition and growth in children with chronic kidney disease. Nat Rev Nephrol. 2011 Sep 27; 7(11):615-23. PMID: 21947116.
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    36. Foster BJ, McCauley L, Mak R. Nutrition in infants and very young children with chronic kidney disease. Pediatr Nephrol. 2012 Sep; 27(9):1427-39. PMID: 21874586.
      View in: PubMed
    37. Furth SL, Abraham AG, Jerry-Fluker J, Schwartz GJ, Benfield M, Kaskel F, Wong C, Mak R, Moxey-Mims M, Warady BA. Metabolic abnormalities, cardiovascular disease risk factors, and GFR decline in children with chronic kidney disease. Clin J Am Soc Nephrol. 2011 Sep; 6(9):2132-40. PMID: 21841064; PMCID: PMC3358991.
    38. Mak R, Ikizler TA, Kovesdy CP, Raj DS, Stenvinkel P, Kalantar-Zadeh K. Erratum to: Wasting in chronic kidney disease. J Cachexia Sarcopenia Muscle. 2011 Jun; 2(2):119. PMID: 22477651; PMCID: PMC3117998.
    39. Kalantar-Zadeh K, Cano NJ, Budde K, Chazot C, Kovesdy CP, Mak R, Mehrotra R, Raj DS, Sehgal AR, Stenvinkel P, Ikizler TA. Diets and enteral supplements for improving outcomes in chronic kidney disease. Nat Rev Nephrol. 2011 May 31; 7(7):369-84. PMID: 21629229; PMCID: PMC3876473.
    40. Ishikura K, Hamasaki Y, Sakai T, Hataya H, Mak R, Honda M. Posterior reversible encephalopathy syndrome in children with kidney diseases. Pediatr Nephrol. 2012 Mar; 27(3):375-84. PMID: 21556718.
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    41. Mak R, Cheung WW. Is ghrelin a biomarker for mortality in end-stage renal disease? Kidney Int. 2011 Apr; 79(7):697-9. PMID: 21403653.
      View in: PubMed
    42. Mak R, Ikizler AT, Kovesdy CP, Raj DS, Stenvinkel P, Kalantar-Zadeh K. Wasting in chronic kidney disease. J Cachexia Sarcopenia Muscle. 2011 Mar; 2(1):9-25. PMID: 21475675.
      View in: PubMed
    43. Mak R, Cheung WW, Zhan JY, Shen Q, Foster BJ. Cachexia and protein-energy wasting in children with chronic kidney disease. Pediatr Nephrol. 2012 Feb; 27(2):173-81. PMID: 21298504; PMCID: PMC3249542.
    44. Cheung WW, Zhan JY, Paik KH, Mak R. The impact of inflammation on bone mass in children. Pediatr Nephrol. 2011 Nov; 26(11):1937-46. PMID: 21197596; PMCID: PMC3178021.
    45. Querfeld U, Mak R. Vitamin D deficiency and toxicity in chronic kidney disease: in search of the therapeutic window. Pediatr Nephrol. 2010 Dec; 25(12):2413-30. PMID: 20567854.
      View in: PubMed
    46. Santos F, Kaskel FJ, Mak R, Caldas A. 8th International Symposium on Growth and Nutrition in Children with Chronic Renal Disease: 28-30 May 2009, Oviedo, Asturias, Spain. Pediatr Nephrol. 2010 Apr; 25(4):581-2. PMID: 20013292; PMCID: PMC2827802.
    47. Cheung WW, Mak R. Ghrelin in chronic kidney disease. Int J Pept. 2010; 2010. PMID: 20721357; PMCID: PMC2915808.
    48. Mak R, Bakris G. Pediatrics: Masked hypertension: a risk factor in children with CKD. Nat Rev Nephrol. 2010 Mar; 6(3):132-4. PMID: 20186228.
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    49. Mak R, Flynn J, Bakris G. Pediatrics: blood pressure target for renoprotection in children. Nat Rev Nephrol. 2010 Feb; 6(2):67-8. PMID: 20111045.
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    50. Cheung WW, Paik KH, Mak R. Inflammation and cachexia in chronic kidney disease. Pediatr Nephrol. 2010 Apr; 25(4):711-24. PMID: 20111974.
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    51. Cheung WW, Mak R. Ghrelin and its analogues as therapeutic agents for anorexia and cachexia in end-stage renal disease. Kidney Int. 2009 Jul; 76(2):135-7. PMID: 19564855.
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    52. Wong CS, Pierce CB, Cole SR, Warady BA, Mak R, Benador NM, Kaskel F, Furth SL, Schwartz GJ. Association of proteinuria with race, cause of chronic kidney disease, and glomerular filtration rate in the chronic kidney disease in children study. Clin J Am Soc Nephrol. 2009 Apr; 4(4):812-9. PMID: 19297612; PMCID: PMC2666424.
    53. Mak R. Recent advances in chronic dialysis and renal transplantation in children. Pediatr Nephrol. 2009 Mar; 24(3):459-61. PMID: 19153772.
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    54. Schwartz GJ, Muñoz A, Schneider MF, Mak R, Kaskel F, Warady BA, Furth SL. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009 Mar; 20(3):629-37. PMID: 19158356; PMCID: PMC2653687.
    55. Mak R. Acute kidney injury in children: the dawn of a new era. Pediatr Nephrol. 2008 Dec; 23(12):2147-9. PMID: 18936981.
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    56. Cheung WW, Rosengren S, Boyle DL, Mak R. Modulation of melanocortin signaling ameliorates uremic cachexia. Kidney Int. 2008 Jul; 74(2):180-6. PMID: 18432186.
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    57. Mak R, Cheung W. Therapeutic strategy for cachexia in chronic kidney disease. Curr Opin Nephrol Hypertens. 2007 Nov; 16(6):542-6. PMID: 18089968.
      View in: PubMed
    58. Mak R, Wong JH. Are oral antibiotics alone efficacious for the treatment of a first episode of acute pyelonephritis in children? Nat Clin Pract Nephrol. 2008 Jan; 4(1):10-1. PMID: 17971799.
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    59. Mak R. Insulin and its role in chronic kidney disease. Pediatr Nephrol. 2008 Mar; 23(3):355-62. PMID: 17929061.
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    60. Mak R, Cheung WW, Roberts CT. The growth hormone-insulin-like growth factor-I axis in chronic kidney disease. Growth Horm IGF Res. 2008 Feb; 18(1):17-25. PMID: 17826224; PMCID: PMC2706146.
    61. Cheung WW, Kuo HJ, Markison S, Chen C, Foster AC, Marks DL, Mak R. Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice. J Am Soc Nephrol. 2007 Sep; 18(9):2517-24. PMID: 17687077.
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    62. Mak R, Cheung W. Adipokines and gut hormones in end-stage renal disease. Perit Dial Int. 2007 Jun; 27 Suppl 2:S298-302. PMID: 17556323.
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    63. Wahba IM, Mak R. Obesity and obesity-initiated metabolic syndrome: mechanistic links to chronic kidney disease. Clin J Am Soc Nephrol. 2007 May; 2(3):550-62. PMID: 17699463.
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    64. Mak R, Cheung W. Cachexia in chronic kidney disease: role of inflammation and neuropeptide signaling. Curr Opin Nephrol Hypertens. 2007 Jan; 16(1):27-31. PMID: 17143068.
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    65. Mak R, Cheung W, Purnell J. Ghrelin in chronic kidney disease: too much or too little? Perit Dial Int. 2007 Jan-Feb; 27(1):51-5. PMID: 17179511.
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    66. Mak R, Proesmans W, Trachtman H. Teaching articles: a new goal of the journal. Pediatr Nephrol. 2007 Jan; 22(1):24-5. PMID: 17086404.
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    67. Mak R. Chronic kidney disease in children: state of the art. Pediatr Nephrol. 2007 Oct; 22(10):1687-8. PMID: 17086403.
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    68. Mak R. Can plasma iohexol disappearance be used to measure GFR in children with chronic kidney disease? Nat Clin Pract Nephrol. 2006 Nov; 2(11):608-9. PMID: 17066046.
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    69. Mak R, Kuo HJ, Cheung WW. Animal models of obesity-associated chronic kidney disease. Adv Chronic Kidney Dis. 2006 Oct; 13(4):374-85. PMID: 17045223.
      View in: PubMed
    70. Mak R, Cheung W, Cone RD, Marks DL. Mechanisms of disease: Cytokine and adipokine signaling in uremic cachexia. Nat Clin Pract Nephrol. 2006 Sep; 2(9):527-34. PMID: 16941045.
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    71. Mak R, Cheung W. Energy homeostasis and cachexia in chronic kidney disease. Pediatr Nephrol. 2006 Dec; 21(12):1807-14. PMID: 16897005.
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    72. Furth SL, Cole SR, Moxey-Mims M, Kaskel F, Mak R, Schwartz G, Wong C, Muñoz A, Warady BA. Design and methods of the Chronic Kidney Disease in Children (CKiD) prospective cohort study. Clin J Am Soc Nephrol. 2006 Sep; 1(5):1006-15. PMID: 17699320; PMCID: PMC3630231.
    73. Mak R, Kuo HJ. Pathogenesis of urinary tract infection: an update. Curr Opin Pediatr. 2006 Apr; 18(2):148-52. PMID: 16601494.
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    74. Cheung W, Yu PX, Little BM, Cone RD, Marks DL, Mak R. Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest. 2005 Jun; 115(6):1659-65. PMID: 15931394; PMCID: PMC1136984.
    75. Mak R, Cheung W, Cone RD, Marks DL. Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease. Pediatr Nephrol. 2005 Mar; 20(3):427-31. PMID: 15662537.
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    76. Mak R, Chang SL, Draksharapu A, Pak YK. Gene expression in uremic left ventricular hypertrophy: effects of hypertension and anemia. Exp Mol Med. 2004 Jun 30; 36(3):251-8. PMID: 15272237.
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    77. Mak R, Chang SL, Pak YK. Growth impairment of primary chondrocyte cells by serum of rats with chronic renal failure. Exp Mol Med. 2004 Jun 30; 36(3):243-50. PMID: 15272236.
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    78. Mak R, Kuo HJ. Primary ureteral reflux: emerging insights from molecular and genetic studies. Curr Opin Pediatr. 2003 Apr; 15(2):181-5. PMID: 12640275.
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