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John Shyy

TitleProfessor In Residence
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0613K
La Jolla CA 92093
Phone858-534-3736
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    Collapse Research 
    Collapse Research Activities and Funding
    Innate Immune Activation and Endothelial Cell Dysfunction in Acute Kawasaki Disease
    NIH/NHLBI R01HL140898Jan 1, 2018 - Nov 30, 2022
    Role: Co-Principal Investigator
    Flow-Induced Endothelial Innate Immunity and Atherosclerosis Susceptibility
    NIH/NHLBI R01HL125643Aug 5, 2016 - Jul 31, 2020
    Role: Principal Investigator
    Systems Biology Analyses for Hemodynamic Regulation of Vascular Homeostasis
    NIH/NHLBI R01HL108735Aug 24, 2012 - Jun 30, 2021
    Role: Principal Investigator
    The miRNA-mediated Translational De-suppression in Hypoxic Endothelium
    NIH/NHLBI R21HL106567Aug 21, 2012 - May 31, 2015
    Role: Principal Investigator
    Shear Regulation of MicroRNA Transportomes and Targetomes in Vascular Homeostasis
    NIH/NHLBI R01HL106579Jan 1, 2011 - Nov 30, 2018
    Role: Principal Investigator
    Shear stress, SIRT1, and Arterial Stiffening
    NIH/NHLBI R01HL105318Sep 20, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Adiponetin and AMPK Biosensor
    NIH/NHLBI R21HL093731Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Shear Stress, AMPK, and Endothelial Functions
    NIH/NHLBI R01HL089940Jan 1, 2009 - Dec 31, 2013
    Role: Principal Investigator
    Flow Regulation of SREBP in Atherosclerosis
    NIH/NHLBI R01HL077448Jul 1, 2004 - Apr 30, 2009
    Role: Principal Investigator
    STRAIN INDUCTION OF VSMC PROLIFERATION AND APOPTOSIS
    NIH/NHLBI R01HL060789Jul 1, 1998 - Jun 30, 2003
    Role: Principal Investigator
    SHEAR STRESS ENHANCEMENT OF SMOOTH MUSCLE CELL MIGRATION
    NIH/NHLBI R01HL056707Jul 1, 1996 - Jun 30, 2005
    Role: Principal Investigator
    MOLECULAR BASIS OF THE ENDOTHELIAL SHEAR STRESS RECEPTOR
    NIH/NHLBI R29HL056707Jul 1, 1996 - Jun 30, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lai B, Li Z, He M, Wang Y, Chen L, Zhang J, Yang Y, Shyy J. Atheroprone flow enhances the endothelial-to-mesenchymal transition. Am J Physiol Heart Circ Physiol. 2018 Jul 27. PMID: 30052471.
      View in: PubMed
    2. Bai L, Shyy J. Shear Stress Regulation of Endothelium: A Double-edged Sword. J Transl Int Med. 2018 Jun; 6(2):58-61. PMID: 29984197.
      View in: PubMed
    3. Zhang J, Dong J, Martin M, He M, Gongol B, Marin TL, Chen L, Shi X, Yin Y, Shang F, Wu Y, Huang HY, Zhang J, Zhang Y, Kang J, Moya EA, Huang HD, Powell FL, Chen Z, Thistlethwaite PA, Yuan ZY, Shyy J. AMPK Phosphorylation of ACE2 in Endothelium Mitigates Pulmonary Hypertension. Am J Respir Crit Care Med. 2018 Mar 23. PMID: 29570986.
      View in: PubMed
    4. Zhang J, Yin Y, Chen L, Chu C, Wang Y, Lv Y, He M, Martin M, Huang PH, Mu JJ, Shyy J, Yuan ZY. Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents. Am J Hypertens. 2018 Jan 12; 31(2):253-260. PMID: 28985241.
      View in: PubMed
    5. Gongol B, Marin T, Johnson DA, Shyy J. Bioinformatics Approach to Identify Novel AMPK Targets. Methods Mol Biol. 2018; 1732:99-109. PMID: 29480471.
      View in: PubMed
    6. Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy J, Sun Z, Tsao PS, Wagenseil JE, Galis ZS. A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension. Circ Res. 2017 Nov 10; 121(11):1216-1218. PMID: 29122942.
      View in: PubMed
    7. Xu MJ, Cai Y, Qu A, Shyy J, Li W, Wang X. Immediate Early Response Gene X-1 (IEX-1) Mediates Ischemic Preconditioning-Induced Cardioprotection in Rats. Oxid Med Cell Longev. 2017; 2017:6109061. PMID: 29213350.
      View in: PubMed
    8. Ajami NE, Gupta S, Maurya MR, Nguyen P, Li JY, Shyy J, Chen Z, Chien S, Subramaniam S. Systems biology analysis of longitudinal functional response of endothelial cells to shear stress. Proc Natl Acad Sci U S A. 2017 Oct 10; 114(41):10990-10995. PMID: 28973892.
      View in: PubMed
    9. Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, Huang HD, Jain M, Jain MK, Subramaniam S, Shyy J. Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. Circulation. 2017 Oct 03; 136(14):1315-1330. PMID: 28794002.
      View in: PubMed
    10. Shang F, Wang SC, Hsu CY, Miao Y, Martin M, Yin Y, Wu CC, Wang YT, Wu G, Chien S, Huang HD, Tarng DC, Shiu YT, Cheung AK, Huang PH, Chen Z, Shyy J. MicroRNA-92a Mediates Endothelial Dysfunction in CKD. J Am Soc Nephrol. 2017 Nov; 28(11):3251-3261. PMID: 28696247.
      View in: PubMed
    11. Bai L, Li Z, Li Q, Guan H, Zhao S, Liu R, Wang R, Zhang J, Jia Y, Fan J, Wang N, Reddy JK, Shyy J, Liu E. Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization. Arterioscler Thromb Vasc Biol. 2017 Aug; 37(8):1470-1481. PMID: 28642237.
      View in: PubMed
    12. Huang TS, Wang KC, Quon S, Nguyen P, Chang TY, Chen Z, Li YS, Subramaniam S, Shyy J, Chien S. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiol Genomics. 2017 Jul 01; 49(7):339-345. PMID: 28500253.
      View in: PubMed
    13. Chen Z, Li S, Subramaniam S, Shyy J, Chien S. Epigenetic Regulation: A New Frontier for Biomedical Engineers. Annu Rev Biomed Eng. 2017 Jun 21; 19:195-219. PMID: 28301736.
      View in: PubMed
    14. Marin TL, Gongol B, Zhang F, Martin M, Johnson DA, Xiao H, Wang Y, Subramaniam S, Chien S, Shyy J. AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1. Sci Signal. 2017 Jan 31; 10(464). PMID: 28143904.
      View in: PubMed
    15. Lin TY, Wei TW, Li S, Wang SC, He M, Martin M, Zhang J, Shentu TP, Xiao H, Kang J, Wang KC, Chen Z, Chien S, Tsai MD, Shyy J. TIFA as a crucial mediator for NLRP3 inflammasome. Proc Natl Acad Sci U S A. 2016 12 27; 113(52):15078-15083. PMID: 27965388.
      View in: PubMed
    16. He M, Chen Z, Martin M, Zhang J, Sangwung P, Woo B, Tremoulet AH, Shimizu C, Jain MK, Burns JC, Shyy J. miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. Circ Res. 2017 Jan 20; 120(2):354-365. PMID: 27923814.
      View in: PubMed
    17. Miller YI, Shyy J. Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation. Trends Endocrinol Metab. 2017 02; 28(2):143-152. PMID: 27931771.
      View in: PubMed
    18. Shentu TP, He M, Sun X, Zhang J, Zhang F, Gongol B, Marin TL, Zhang J, Wen L, Wang Y, Geary GG, Zhu Y, Johnson DA, Shyy J. AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function. Arterioscler Thromb Vasc Biol. 2016 Dec; 36(12):2358-2368. PMID: 27758765.
      View in: PubMed
    19. Shang F, Zhang J, Li Z, Zhang J, Yin Y, Wang Y, Marin TL, Gongol B, Xiao H, Zhang YY, Chen Z, Shyy J, Lei T. Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. PLoS One. 2016; 11(3):e0151845. PMID: 26986624; PMCID: PMC4795690.
    20. Lin TC, Su CY, Wu PY, Lai TC, Pan WA, Jan YH, Chang YC, Yeh CT, Chen CL, Ger LP, Chang HT, Yang CJ, Huang MS, Liu YP, Lin YF, Shyy J, Tsai MD, Hsiao M. The nucleolar protein NIFK promotes cancer progression via CK1a/ß-catenin in metastasis and Ki-67-dependent cell proliferation. Elife. 2016 Mar 17; 5. PMID: 26984280; PMCID: PMC4811767.
    21. Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy J, Zhu Y. Activation of integrin a5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):769-74. PMID: 26733684; PMCID: PMC4725528.
    22. Marin TL, Gongol B, Martin M, King SJ, Smith L, Johnson DA, Subramaniam S, Chien S, Shyy J. Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome. BMC Syst Biol. 2015 Mar 11; 9:13. PMID: 25890336; PMCID: PMC4357066.
    23. Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy J. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. Circulation. 2015 Mar 03; 131(9):805-14. PMID: 25550450; PMCID: PMC4351177.
    24. Chen Z, Martin M, Li Z, Shyy J. Endothelial dysfunction: the role of sterol regulatory element-binding protein-induced NOD-like receptor family pyrin domain-containing protein 3 inflammasome in atherosclerosis. Curr Opin Lipidol. 2014 Oct; 25(5):339-49. PMID: 25188917; PMCID: PMC4339278.
    25. Wang X, Fang X, Zhou J, Chen Z, Zhao B, Xiao L, Liu A, Li YS, Shyy J, Guan Y, Chien S, Wang N. Shear stress activation of nuclear receptor PXR in endothelial detoxification. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):13174-9. PMID: 23878263; PMCID: PMC3740860.
    26. Xiao H, Lu M, Lin TY, Chen Z, Chen G, Wang WC, Marin T, Shentu TP, Wen L, Gongol B, Sun W, Liang X, Chen J, Huang HD, Pedra JH, Johnson DA, Shyy J. Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility. Circulation. 2013 Aug 06; 128(6):632-42. PMID: 23838163; PMCID: PMC3798034.
    27. Wen L, Chen Z, Zhang F, Cui X, Sun W, Geary GG, Wang Y, Johnson DA, Zhu Y, Chien S, Shyy J. Ca2+/calmodulin-dependent protein kinase kinase ß phosphorylation of Sirtuin 1 in endothelium is atheroprotective. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2420-7. PMID: 23754392; PMCID: PMC3696824.
    28. Marin T, Gongol B, Chen Z, Woo B, Subramaniam S, Chien S, Shyy J. Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state. Free Radic Biol Med. 2013 Sep; 64:61-8. PMID: 23727269; PMCID: PMC3762952.
    29. Chen Z, Shentu TP, Wen L, Johnson DA, Shyy J. Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium. Antioxid Redox Signal. 2013 Nov 01; 19(13):1522-38. PMID: 23477488; PMCID: PMC3797452.
    30. Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, Chiu JJ, Shyy J, Chien S. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013 Jun 21; 113(1):40-51. PMID: 23603512; PMCID: PMC3772783.
    31. He M, Liang X, He L, Wen W, Zhao S, Wen L, Liu Y, Shyy J, Yuan Z. Endothelial dysfunction in rheumatoid arthritis: the role of monocyte chemotactic protein-1-induced protein. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1384-91. PMID: 23580143.
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    32. Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy J, Huang Y, Wang N. Response to overexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation. Hypertension. 2013 Apr; 61(4):e30. PMID: 23607134.
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    33. Chen Z, Lai TC, Jan YH, Lin FM, Wang WC, Xiao H, Wang YT, Sun W, Cui X, Li YS, Fang T, Zhao H, Padmanabhan C, Sun R, Wang DL, Jin H, Chau GY, Huang HD, Hsiao M, Shyy J. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J Clin Invest. 2013 Mar; 123(3):1057-67. PMID: 23426184; PMCID: PMC3582133.
    34. Gongol B, Marin T, Peng IC, Woo B, Martin M, King S, Sun W, Johnson DA, Chien S, Shyy J. AMPKa2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3161-6. PMID: 23382195; PMCID: PMC3581905.
    35. Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy J, Huang Y, Wang N. Peroxisome proliferator-activated receptor-? ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor. Hypertension. 2012 Dec; 60(6):1471-8. PMID: 23108648.
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    36. Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, Huang J, Wang WC, Lin FM, Chen Z, Huang HD, Shyy J, Liang JT, Chen RH. miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. Cancer Res. 2012 Jul 15; 72(14):3631-41. PMID: 22593189.
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    37. Huang CC, Weng JH, Wei TY, Wu PY, Hsu PH, Chen YH, Wang SC, Qin D, Hung CC, Chen ST, Wang AH, Shyy J, Tsai MD. Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-?B activation. Mol Cell Biol. 2012 Jul; 32(14):2664-73. PMID: 22566686; PMCID: PMC3416184.
    38. Vandrangi P, Sosa M, Shyy J, Rodgers VG. Flow-dependent mass transfer may trigger endothelial signaling cascades. PLoS One. 2012; 7(4):e35260. PMID: 22558132; PMCID: PMC3338739.
    39. Peng IC, Chen Z, Sun W, Li YS, Marin TL, Hsu PH, Su MI, Cui X, Pan S, Lytle CY, Johnson DA, Blaeser F, Chatila T, Shyy J. Glucagon regulates ACC activity in adipocytes through the CAMKKß/AMPK pathway. Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1560-8. PMID: 22454291; PMCID: PMC3378158.
    40. Wu W, Xiao H, Laguna-Fernandez A, Villarreal G, Wang KC, Geary GG, Zhang Y, Wang WC, Huang HD, Zhou J, Li YS, Chien S, Garcia-Cardena G, Shyy J. Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation. 2011 Aug 02; 124(5):633-41. PMID: 21768538; PMCID: PMC3511909.
    41. Zhou J, Wang KC, Wu W, Subramaniam S, Shyy J, Chiu JJ, Li JY, Chien S. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10355-60. PMID: 21636785; PMCID: PMC3121870.
    42. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy J, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011 Apr 06; 13(4):376-388. PMID: 21459323; PMCID: PMC3086578.
    43. Fu Y, Hou Y, Fu C, Gu M, Li C, Kong W, Wang X, Shyy J, Zhu Y. A novel mechanism of ?/d T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase ß chain. Circ Res. 2011 Feb 18; 108(4):410-7. PMID: 21193741; PMCID: PMC3053136.
    44. Lin CT, Tang HY, Han YS, Liu HP, Huang SF, Chien CH, Shyy J, Chiu JJ, Chen X. Downregulation of Signaling-active IGF-1 by Dipeptidyl Peptidase IV (DPP-IV). Int J Biomed Sci. 2010 Dec; 6(4):301-9. PMID: 23675206; PMCID: PMC3615292.
    45. Zheng S, Li W, Xu M, Bai X, Zhou Z, Han J, Shyy J, Wang X. Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1485-92. PMID: 20881236.
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    46. Wang P, Jiang Y, Wang Y, Shyy J, DeFea KA. Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2. BMC Biochem. 2010 Sep 21; 11:36. PMID: 20858278; PMCID: PMC2955585.
    47. Sun W, Julie Li YS, Huang HD, Shyy J, Chien S. microRNA: a master regulator of cellular processes for bioengineering systems. Annu Rev Biomed Eng. 2010 Aug 15; 12:1-27. PMID: 20415587.
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    48. Chen Z, Peng IC, Cui X, Li YS, Chien S, Shyy J. Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10268-73. PMID: 20479254; PMCID: PMC2890429.
    49. Fu C, He J, Li C, Shyy J, Zhu Y. Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae. Biochim Biophys Acta. 2010 Jul; 1801(7):702-10. PMID: 20382259.
      View in: PubMed
    50. Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang N, Shyy J, Li YS, Chien S. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3234-9. PMID: 20133741; PMCID: PMC2840325.
    51. Ai D, Shyy J, Zhu Y. Linking an insect enzyme to hypertension: angiotensin II-epoxide hydrolase interactions. Kidney Int. 2010 Jan; 77(2):88-92. PMID: 19847158.
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    52. Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy J, Chien S, García-Cardeña G. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1902-8. PMID: 19696400; PMCID: PMC2766008.
    53. Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, Czernin J, Shyy J, Watson AD, Phelps M, Radu CG, Cloughesy TF, Mischel PS. The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12932-7. PMID: 19625624.
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    54. Yuan H, Shyy J, Martins-Green M. Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1. J Hepatol. 2009 Sep; 51(3):535-47. PMID: 19556020; PMCID: PMC3000896.
    55. Shyy J. Extracellular matrix differentiating good flow versus bad flow. Circ Res. 2009 Apr 24; 104(8):931-2. PMID: 19390061; PMCID: PMC2749748.
    56. Xie X, Liao H, Dang H, Pang W, Guan Y, Wang X, Shyy J, Zhu Y, Sladek FM. Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs. Mol Endocrinol. 2009 Apr; 23(4):434-43. PMID: 19179483; PMCID: PMC2667705.
    57. Chen Z, Peng IC, Sun W, Su MI, Hsu PH, Fu Y, Zhu Y, DeFea K, Pan S, Tsai MD, Shyy J. AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res. 2009 Feb 27; 104(4):496-505. PMID: 19131647; PMCID: PMC2761102.
    58. Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy J, Hammock BD, Zhu Y. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):564-9. PMID: 19126686; PMCID: PMC2626743.
    59. Dang H, Liu Y, Pang W, Li C, Wang N, Shyy J, Zhu Y. Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. J Biol Chem. 2009 Mar 06; 284(10):6218-26. PMID: 19119143; PMCID: PMC2649084.
    60. Li X, Han Y, Pang W, Li C, Xie X, Shyy J, Zhu Y. AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2008 Oct; 28(10):1789-95. PMID: 18599796; PMCID: PMC2737684.
    61. Ouyang M, Lu S, Li XY, Xu J, Seong J, Giepmans BN, Shyy J, Weiss SJ, Wang Y. Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging. J Biol Chem. 2008 Jun 20; 283(25):17740-8. PMID: 18441011; PMCID: PMC2427332.
    62. Wang Y, Shyy J, Chien S. Fluorescence proteins, live-cell imaging, and mechanobiology: seeing is believing. Annu Rev Biomed Eng. 2008; 10:1-38. PMID: 18647110.
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    63. Zhu M, Fu Y, Hou Y, Wang N, Guan Y, Tang C, Shyy J, Zhu Y. Laminar shear stress regulates liver X receptor in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):527-33. PMID: 18096827.
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    64. Benallaoua M, François M, Batteux F, Thelier N, Shyy J, Fitting C, Tsagris L, Boczkowski J, Savouret JF, Corvol MT, Poiraudeau S, Rannou F. Pharmacologic induction of heme oxygenase 1 reduces acute inflammatory arthritis in mice. Arthritis Rheum. 2007 Aug; 56(8):2585-94. PMID: 17665394.
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    65. Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy J, Zhu Y. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):9018-23. PMID: 17495027; PMCID: PMC1885620.
    66. Guo D, Chien S, Shyy J. Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and Akt pathways. Circ Res. 2007 Mar 02; 100(4):564-71. PMID: 17272808.
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    67. Sun W, Lee TS, Zhu M, Gu C, Wang Y, Zhu Y, Shyy J. Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation. 2006 Dec 12; 114(24):2655-62. PMID: 17116771.
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    68. Wang T, Chen Z, Wang X, Shyy J, Zhu Y. Cholesterol loading increases the translocation of ATP synthase beta chain into membrane caveolae in vascular endothelial cells. Biochim Biophys Acta. 2006 Oct; 1761(10):1182-90. PMID: 16996794.
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    69. Yao M, Zhou RH, Petreaca M, Zheng L, Shyy J, Martins-Green M. Activation of sterol regulatory element-binding proteins (SREBPs) is critical in IL-8-induced angiogenesis. J Leukoc Biol. 2006 Sep; 80(3):608-20. PMID: 16849610.
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    70. Zhang Y, Lee TS, Kolb EM, Sun K, Lu X, Sladek FM, Kassab GS, Garland T, Shyy J. AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress. Arterioscler Thromb Vasc Biol. 2006 Jun; 26(6):1281-7. PMID: 16601232.
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    71. Lu M, Shyy J. Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation. Am J Physiol Cell Physiol. 2006 Jun; 290(6):C1477-86. PMID: 16381800.
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    72. Liu Y, Zhang Y, Schmelzer K, Lee TS, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy J. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16747-52. PMID: 16267130; PMCID: PMC1276614.
    73. Zhu Y, Liao H, Xie X, Yuan Y, Lee TS, Wang N, Wang X, Shyy J, Stemerman MB. Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). Cardiovasc Res. 2005 Dec 01; 68(3):425-32. PMID: 16099444.
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    74. Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy J, Hammock BD, Spector AA. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther. 2005 Jul; 314(1):260-70. PMID: 15798002.
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    75. Yeh M, Cole AL, Choi J, Liu Y, Tulchinsky D, Qiao JH, Fishbein MC, Dooley AN, Hovnanian T, Mouilleseaux K, Vora DK, Yang WP, Gargalovic P, Kirchgessner T, Shyy J, Berliner JA. Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products. Circ Res. 2004 Oct 15; 95(8):780-8. PMID: 15388640.
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    76. Zeng L, Liao H, Liu Y, Lee TS, Zhu M, Wang X, Stemerman MB, Zhu Y, Shyy J. Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J Biol Chem. 2004 Nov 19; 279(47):48801-7. PMID: 15358760.
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    77. Lee TS, Chang CC, Zhu Y, Shyy J. Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection. Circulation. 2004 Sep 07; 110(10):1296-302. PMID: 15337692.
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    85. Zeng L, Zhang Y, Chien S, Liu X, Shyy J. The role of p53 deacetylation in p21Waf1 regulation by laminar flow. J Biol Chem. 2003 Jul 04; 278(27):24594-9. PMID: 12716906.
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    88. Yajima N, Masuda M, Miyazaki M, Nakajima N, Chien S, Shyy J. Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray. J Vasc Surg. 2002 Aug; 36(2):379-85. PMID: 12170221.
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