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John Shyy

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0613K
La Jolla CA 92093
Phone8/5-34--3736
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    Collapse Research 
    Collapse Research Activities and Funding
    Innate Immune Activation and Endothelial Cell Dysfunction in Acute Kawasaki Disease
    NIH/NHLBI R01HL140898Jan 1, 2018 - Nov 30, 2022
    Role: Co-Principal Investigator
    Flow-Induced Endothelial Innate Immunity and Atherosclerosis Susceptibility
    NIH/NHLBI R01HL125643Aug 5, 2016 - Jul 31, 2020
    Role: Principal Investigator
    Systems Biology Analyses for Hemodynamic Regulation of Vascular Homeostasis
    NIH/NHLBI R01HL108735Aug 24, 2012 - Jun 30, 2021
    Role: Principal Investigator
    The miRNA-mediated Translational De-suppression in Hypoxic Endothelium
    NIH/NHLBI R21HL106567Aug 21, 2012 - May 31, 2015
    Role: Principal Investigator
    Nucleolin Regulation of miRome by Shear Stress
    NIH/NHLBI R01HL106579Jan 1, 2011 - Nov 30, 2022
    Role: Principal Investigator
    Shear stress, SIRT1, and Arterial Stiffening
    NIH/NHLBI R01HL105318Sep 20, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Adiponetin and AMPK Biosensor
    NIH/NHLBI R21HL093731Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Shear Stress, AMPK, and Endothelial Functions
    NIH/NHLBI R01HL089940Jan 1, 2009 - Oct 31, 2010
    Role: Principal Investigator
    Flow Regulation of SREBP in Atherosclerosis
    NIH/NHLBI R01HL077448Jul 1, 2004 - Apr 30, 2009
    Role: Principal Investigator
    STRAIN INDUCTION OF VSMC PROLIFERATION AND APOPTOSIS
    NIH/NHLBI R01HL060789Jul 1, 1998 - Jun 30, 2003
    Role: Principal Investigator
    SHEAR STRESS ENHANCEMENT OF SMOOTH MUSCLE CELL MIGRATION
    NIH/NHLBI R01HL056707Jul 1, 1996 - Jun 30, 2005
    Role: Principal Investigator
    MOLECULAR BASIS OF THE ENDOTHELIAL SHEAR STRESS RECEPTOR
    NIH/NHLBI R29HL056707Jul 1, 1996 - Jun 30, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. MDM2-Mediated Ubiquitination of ACE2 Contributes to the Development of Pulmonary Arterial Hypertension. Circulation. 2020 Jul 28. Shen H, Zhang J, Wang C, Jain PP, Xiong M, Shi X, Lei Y, Chen S, Yin Q, Thistlethwaite PA, Wang J, Gong K, Yuan ZY, Yuan JX, Shyy JY. PMID: 32755395.
      View in: PubMed   Mentions:    Fields:    
    2. MicroRNA-483 amelioration of experimental pulmonary hypertension. EMBO Mol Med. 2020 May 08; 12(5):e11303. Zhang J, He Y, Yan X, Chen S, He M, Lei Y, Zhang J, Gongol B, Gu M, Miao Y, Bai L, Cui X, Wang X, Zhang Y, Fan F, Li Z, Shen Y, Chou CH, Huang HD, Malhotra A, Rabinovitch M, Jing ZC, Shyy JY. PMID: 32324970.
      View in: PubMed   Mentions:    Fields:    
    3. Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels. Am J Physiol Cell Physiol. 2020 05 01; 318(5):C954-C968. Song S, Babicheva A, Zhao T, Ayon RJ, Rodriguez M, Rahimi S, Balistrieri F, Harrington A, Shyy JY, Thistlethwaite PA, Makino A, Yuan JX. PMID: 32186932.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Shear stress regulation of miR-93 and miR-484 maturation through nucleolin. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):12974-12979. Gongol B, Marin T, Zhang J, Wang SC, Sun W, He M, Chen S, Chen L, Li J, Liu JH, Martin M, Han Y, Kang J, Johnson DA, Lytle C, Li YS, Huang PH, Chien S, Shyy JY. PMID: 31182601.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications. Arterioscler Thromb Vasc Biol. 2019 05; 39(5):902-914. He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, Shyy JY. PMID: 30917677.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Germline BMP9 mutation causes idiopathic pulmonary arterial hypertension. Eur Respir J. 2019 03; 53(3). Wang XJ, Lian TY, Jiang X, Liu SF, Li SQ, Jiang R, Wu WH, Ye J, Cheng CY, Du Y, Xu XQ, Wu Y, Peng FH, Sun K, Mao YM, Yu H, Liang C, Shyy JY, Zhang SY, Zhang X, Jing ZC. PMID: 30578397.
      View in: PubMed   Mentions: 5     Fields:    
    7. AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension. Am J Respir Crit Care Med. 2018 08 15; 198(4):509-520. Zhang J, Dong J, Martin M, He M, Gongol B, Marin TL, Chen L, Shi X, Yin Y, Shang F, Wu Y, Huang HY, Zhang J, Zhang Y, Kang J, Moya EA, Huang HD, Powell FL, Chen Z, Thistlethwaite PA, Yuan ZY, Shyy JY. PMID: 29570986.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    8. Atheroprone flow enhances the endothelial-to-mesenchymal transition. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1293-H1303. Lai B, Li Z, He M, Wang Y, Chen L, Zhang J, Yang Y, Shyy JY. PMID: 30052471.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Shear Stress Regulation of Endothelium: A Double-edged Sword. J Transl Int Med. 2018 Jun; 6(2):58-61. Bai L, Shyy JY. PMID: 29984197.
      View in: PubMed   Mentions:
    10. Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents. Am J Hypertens. 2018 01 12; 31(2):253-260. Zhang J, Yin Y, Chen L, Chu C, Wang Y, Lv Y, He M, Martin M, Huang PH, Mu JJ, Shyy JY, Yuan ZY. PMID: 28985241.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Bioinformatics Approach to Identify Novel AMPK Targets. Methods Mol Biol. 2018; 1732:99-109. Gongol B, Marin T, Johnson DA, Shyy JY. PMID: 29480471.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    12. A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension. Circ Res. 2017 11 10; 121(11):1216-1218. Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS. PMID: 29122942.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Immediate Early Response Gene X-1 (IEX-1) Mediates Ischemic Preconditioning-Induced Cardioprotection in Rats. Oxid Med Cell Longev. 2017; 2017:6109061. Xu MJ, Cai Y, Qu A, Shyy JY, Li W, Wang X. PMID: 29213350.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Systems biology analysis of longitudinal functional response of endothelial cells to shear stress. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):10990-10995. Ajami NE, Gupta S, Maurya MR, Nguyen P, Li JY, Shyy JY, Chen Z, Chien S, Subramaniam S. PMID: 28973892.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. Circulation. 2017 Oct 03; 136(14):1315-1330. Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, Huang HD, Jain M, Jain MK, Subramaniam S, Shyy JY. PMID: 28794002.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    16. MicroRNA-92a Mediates Endothelial Dysfunction in CKD. J Am Soc Nephrol. 2017 Nov; 28(11):3251-3261. Shang F, Wang SC, Hsu CY, Miao Y, Martin M, Yin Y, Wu CC, Wang YT, Wu G, Chien S, Huang HD, Tarng DC, Shiu YT, Cheung AK, Huang PH, Chen Z, Shyy JY. PMID: 28696247.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    17. Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization. Arterioscler Thromb Vasc Biol. 2017 08; 37(8):1470-1481. Bai L, Li Z, Li Q, Guan H, Zhao S, Liu R, Wang R, Zhang J, Jia Y, Fan J, Wang N, Reddy JK, Shyy JY, Liu E. PMID: 28642237.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    18. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiol Genomics. 2017 Jul 01; 49(7):339-345. Huang TS, Wang KC, Quon S, Nguyen P, Chang TY, Chen Z, Li YS, Subramaniam S, Shyy J, Chien S. PMID: 28500253.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    19. Epigenetic Regulation: A New Frontier for Biomedical Engineers. Annu Rev Biomed Eng. 2017 06 21; 19:195-219. Chen Z, Li S, Subramaniam S, Shyy JY, Chien S. PMID: 28301736.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    20. AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1. Sci Signal. 2017 01 31; 10(464). Marin TL, Gongol B, Zhang F, Martin M, Johnson DA, Xiao H, Wang Y, Subramaniam S, Chien S, Shyy JY. PMID: 28143904.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    21. TIFA as a crucial mediator for NLRP3 inflammasome. Proc Natl Acad Sci U S A. 2016 12 27; 113(52):15078-15083. Lin TY, Wei TW, Li S, Wang SC, He M, Martin M, Zhang J, Shentu TP, Xiao H, Kang J, Wang KC, Chen Z, Chien S, Tsai MD, Shyy JY. PMID: 27965388.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. Circ Res. 2017 Jan 20; 120(2):354-365. He M, Chen Z, Martin M, Zhang J, Sangwung P, Woo B, Tremoulet AH, Shimizu C, Jain MK, Burns JC, Shyy JY. PMID: 27923814.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    23. Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation. Trends Endocrinol Metab. 2017 02; 28(2):143-152. Miller YI, Shyy JY. PMID: 27931771.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    24. AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function. Arterioscler Thromb Vasc Biol. 2016 12; 36(12):2358-2368. Shentu TP, He M, Sun X, Zhang J, Zhang F, Gongol B, Marin TL, Zhang J, Wen L, Wang Y, Geary GG, Zhu Y, Johnson DA, Shyy JY. PMID: 27758765.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    25. The nucleolar protein NIFK promotes cancer progression via CK1a/ß-catenin in metastasis and Ki-67-dependent cell proliferation. Elife. 2016 Mar 17; 5. Lin TC, Su CY, Wu PY, Lai TC, Pan WA, Jan YH, Chang YC, Yeh CT, Chen CL, Ger LP, Chang HT, Yang CJ, Huang MS, Liu YP, Lin YF, Shyy JY, Tsai MD, Hsiao M. PMID: 26984280.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    26. Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. PLoS One. 2016; 11(3):e0151845. Shang F, Zhang J, Li Z, Zhang J, Yin Y, Wang Y, Marin TL, Gongol B, Xiao H, Zhang YY, Chen Z, Shyy JY, Lei T. PMID: 26986624.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    27. Activation of integrin a5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):769-74. Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy JY, Zhu Y. PMID: 26733684.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    28. Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome. BMC Syst Biol. 2015 Mar 11; 9:13. Marin TL, Gongol B, Martin M, King SJ, Smith L, Johnson DA, Subramaniam S, Chien S, Shyy JY. PMID: 25890336.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. Circulation. 2015 Mar 03; 131(9):805-14. Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy JY. PMID: 25550450.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    30. Endothelial dysfunction: the role of sterol regulatory element-binding protein-induced NOD-like receptor family pyrin domain-containing protein 3 inflammasome in atherosclerosis. Curr Opin Lipidol. 2014 Oct; 25(5):339-49. Chen Z, Martin M, Li Z, Shyy JY. PMID: 25188917.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    31. Shear stress activation of nuclear receptor PXR in endothelial detoxification. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):13174-9. Wang X, Fang X, Zhou J, Chen Z, Zhao B, Xiao L, Liu A, Li YS, Shyy JY, Guan Y, Chien S, Wang N. PMID: 23878263.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    32. Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility. Circulation. 2013 Aug 06; 128(6):632-42. Xiao H, Lu M, Lin TY, Chen Z, Chen G, Wang WC, Marin T, Shentu TP, Wen L, Gongol B, Sun W, Liang X, Chen J, Huang HD, Pedra JH, Johnson DA, Shyy JY. PMID: 23838163.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    33. Ca2+/calmodulin-dependent protein kinase kinase ß phosphorylation of Sirtuin 1 in endothelium is atheroprotective. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2420-7. Wen L, Chen Z, Zhang F, Cui X, Sun W, Geary GG, Wang Y, Johnson DA, Zhu Y, Chien S, Shyy JY. PMID: 23754392.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    34. Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state. Free Radic Biol Med. 2013 Sep; 64:61-8. Marin T, Gongol B, Chen Z, Woo B, Subramaniam S, Chien S, Shyy JY. PMID: 23727269.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    35. Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium. Antioxid Redox Signal. 2013 Nov 01; 19(13):1522-38. Chen Z, Shentu TP, Wen L, Johnson DA, Shyy JY. PMID: 23477488.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    36. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013 Jun 21; 113(1):40-51. Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, Chiu JJ, Shyy JY, Chien S. PMID: 23603512.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    37. Endothelial dysfunction in rheumatoid arthritis: the role of monocyte chemotactic protein-1-induced protein. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1384-91. He M, Liang X, He L, Wen W, Zhao S, Wen L, Liu Y, Shyy JY, Yuan Z. PMID: 23580143.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    38. Response to overexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation. Hypertension. 2013 Apr; 61(4):e30. Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JY, Huang Y, Wang N. PMID: 23607134.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    39. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J Clin Invest. 2013 Mar; 123(3):1057-67. Chen Z, Lai TC, Jan YH, Lin FM, Wang WC, Xiao H, Wang YT, Sun W, Cui X, Li YS, Fang T, Zhao H, Padmanabhan C, Sun R, Wang DL, Jin H, Chau GY, Huang HD, Hsiao M, Shyy JY. PMID: 23426184.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    40. AMPKa2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3161-6. Gongol B, Marin T, Peng IC, Woo B, Martin M, King S, Sun W, Johnson DA, Chien S, Shyy JY. PMID: 23382195.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    41. Peroxisome proliferator-activated receptor-? ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor. Hypertension. 2012 Dec; 60(6):1471-8. Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JY, Huang Y, Wang N. PMID: 23108648.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    42. miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. Cancer Res. 2012 Jul 15; 72(14):3631-41. Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, Huang J, Wang WC, Lin FM, Chen Z, Huang HD, Shyy JY, Liang JT, Chen RH. PMID: 22593189.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    43. Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-?B activation. Mol Cell Biol. 2012 Jul; 32(14):2664-73. Huang CC, Weng JH, Wei TY, Wu PY, Hsu PH, Chen YH, Wang SC, Qin D, Hung CC, Chen ST, Wang AH, Shyy JY, Tsai MD. PMID: 22566686.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    44. Flow-dependent mass transfer may trigger endothelial signaling cascades. PLoS One. 2012; 7(4):e35260. Vandrangi P, Sosa M, Shyy JY, Rodgers VG. PMID: 22558132.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    45. Glucagon regulates ACC activity in adipocytes through the CAMKKß/AMPK pathway. Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1560-8. Peng IC, Chen Z, Sun W, Li YS, Marin TL, Hsu PH, Su MI, Cui X, Pan S, Lytle CY, Johnson DA, Blaeser F, Chatila T, Shyy JY. PMID: 22454291.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    46. Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation. 2011 Aug 02; 124(5):633-41. Wu W, Xiao H, Laguna-Fernandez A, Villarreal G, Wang KC, Geary GG, Zhang Y, Wang WC, Huang HD, Zhou J, Li YS, Chien S, Garcia-Cardena G, Shyy JY. PMID: 21768538.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    47. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10355-60. Zhou J, Wang KC, Wu W, Subramaniam S, Shyy JY, Chiu JJ, Li JY, Chien S. PMID: 21636785.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    48. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011 Apr 06; 13(4):376-388. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M. PMID: 21459323.
      View in: PubMed   Mentions: 343     Fields:    Translation:HumansAnimalsCells
    49. A novel mechanism of ?/d T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase ß chain. Circ Res. 2011 Feb 18; 108(4):410-7. Fu Y, Hou Y, Fu C, Gu M, Li C, Kong W, Wang X, Shyy JY, Zhu Y. PMID: 21193741.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    50. Downregulation of Signaling-active IGF-1 by Dipeptidyl Peptidase IV (DPP-IV). Int J Biomed Sci. 2010 Dec; 6(4):301-9. Lin CT, Tang HY, Han YS, Liu HP, Huang SF, Chien CH, Shyy J, Chiu JJ, Chen X. PMID: 23675206.
      View in: PubMed   Mentions:
    51. Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1485-92. Zheng S, Li W, Xu M, Bai X, Zhou Z, Han J, Shyy JY, Wang X. PMID: 20881236.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    52. Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2. BMC Biochem. 2010 Sep 21; 11:36. Wang P, Jiang Y, Wang Y, Shyy JY, DeFea KA. PMID: 20858278.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    53. microRNA: a master regulator of cellular processes for bioengineering systems. Annu Rev Biomed Eng. 2010 Aug 15; 12:1-27. Sun W, Julie Li YS, Huang HD, Shyy JY, Chien S. PMID: 20415587.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimals
    54. Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10268-73. Chen Z, Peng IC, Cui X, Li YS, Chien S, Shyy JY. PMID: 20479254.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    55. Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae. Biochim Biophys Acta. 2010 Jul; 1801(7):702-10. Fu C, He J, Li C, Shyy JY, Zhu Y. PMID: 20382259.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    56. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3234-9. Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang N, Shyy JY, Li YS, Chien S. PMID: 20133741.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    57. Linking an insect enzyme to hypertension: angiotensin II-epoxide hydrolase interactions. Kidney Int. 2010 Jan; 77(2):88-92. Ai D, Shyy JY, Zhu Y. PMID: 19847158.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    58. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1902-8. Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy JY, Chien S, García-Cardeña G. PMID: 19696400.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    59. The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12932-7. Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, Czernin J, Shyy JY, Watson AD, Phelps M, Radu CG, Cloughesy TF, Mischel PS. PMID: 19625624.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    60. Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1. J Hepatol. 2009 Sep; 51(3):535-47. Yuan H, Shyy JY, Martins-Green M. PMID: 19556020.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCellsPHPublic Health
    61. Extracellular matrix differentiating good flow versus bad flow. Circ Res. 2009 Apr 24; 104(8):931-2. Shyy JY. PMID: 19390061.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    62. Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs. Mol Endocrinol. 2009 Apr; 23(4):434-43. Xie X, Liao H, Dang H, Pang W, Guan Y, Wang X, Shyy JY, Zhu Y, Sladek FM. PMID: 19179483.
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    63. AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res. 2009 Feb 27; 104(4):496-505. Chen Z, Peng IC, Sun W, Su MI, Hsu PH, Fu Y, Zhu Y, DeFea K, Pan S, Tsai MD, Shyy JY. PMID: 19131647.
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    64. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):564-9. Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD, Zhu Y. PMID: 19126686.
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    65. Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. J Biol Chem. 2009 Mar 06; 284(10):6218-26. Dang H, Liu Y, Pang W, Li C, Wang N, Shyy JY, Zhu Y. PMID: 19119143.
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    66. AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2008 Oct; 28(10):1789-95. Li X, Han Y, Pang W, Li C, Xie X, Shyy JY, Zhu Y. PMID: 18599796.
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    67. Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging. J Biol Chem. 2008 Jun 20; 283(25):17740-8. Ouyang M, Lu S, Li XY, Xu J, Seong J, Giepmans BN, Shyy JY, Weiss SJ, Wang Y. PMID: 18441011.
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    68. Fluorescence proteins, live-cell imaging, and mechanobiology: seeing is believing. Annu Rev Biomed Eng. 2008; 10:1-38. Wang Y, Shyy JY, Chien S. PMID: 18647110.
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    69. Laminar shear stress regulates liver X receptor in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):527-33. Zhu M, Fu Y, Hou Y, Wang N, Guan Y, Tang C, Shyy JY, Zhu Y. PMID: 18096827.
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    70. Pharmacologic induction of heme oxygenase 1 reduces acute inflammatory arthritis in mice. Arthritis Rheum. 2007 Aug; 56(8):2585-94. Benallaoua M, François M, Batteux F, Thelier N, Shyy JY, Fitting C, Tsagris L, Boczkowski J, Savouret JF, Corvol MT, Poiraudeau S, Rannou F. PMID: 17665394.
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    71. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):9018-23. Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY, Zhu Y. PMID: 17495027.
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    72. Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and Akt pathways. Circ Res. 2007 Mar 02; 100(4):564-71. Guo D, Chien S, Shyy JY. PMID: 17272808.
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    73. Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation. 2006 Dec 12; 114(24):2655-62. Sun W, Lee TS, Zhu M, Gu C, Wang Y, Zhu Y, Shyy JY. PMID: 17116771.
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    74. Cholesterol loading increases the translocation of ATP synthase beta chain into membrane caveolae in vascular endothelial cells. Biochim Biophys Acta. 2006 Oct; 1761(10):1182-90. Wang T, Chen Z, Wang X, Shyy JY, Zhu Y. PMID: 16996794.
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    75. Activation of sterol regulatory element-binding proteins (SREBPs) is critical in IL-8-induced angiogenesis. J Leukoc Biol. 2006 Sep; 80(3):608-20. Yao M, Zhou RH, Petreaca M, Zheng L, Shyy J, Martins-Green M. PMID: 16849610.
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    76. AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress. Arterioscler Thromb Vasc Biol. 2006 Jun; 26(6):1281-7. Zhang Y, Lee TS, Kolb EM, Sun K, Lu X, Sladek FM, Kassab GS, Garland T, Shyy JY. PMID: 16601232.
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    77. Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation. Am J Physiol Cell Physiol. 2006 Jun; 290(6):C1477-86. Lu M, Shyy JY. PMID: 16381800.
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    78. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16747-52. Liu Y, Zhang Y, Schmelzer K, Lee TS, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy JY. PMID: 16267130.
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    79. Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). Cardiovasc Res. 2005 Dec 01; 68(3):425-32. Zhu Y, Liao H, Xie X, Yuan Y, Lee TS, Wang N, Wang X, Shyy JY, Stemerman MB. PMID: 16099444.
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    80. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther. 2005 Jul; 314(1):260-70. Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy JY, Hammock BD, Spector AA. PMID: 15798002.
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    81. Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products. Circ Res. 2004 Oct 15; 95(8):780-8. Yeh M, Cole AL, Choi J, Liu Y, Tulchinsky D, Qiao JH, Fishbein MC, Dooley AN, Hovnanian T, Mouilleseaux K, Vora DK, Yang WP, Gargalovic P, Kirchgessner T, Shyy JY, Berliner JA. PMID: 15388640.
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    82. Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J Biol Chem. 2004 Nov 19; 279(47):48801-7. Zeng L, Liao H, Liu Y, Lee TS, Zhu M, Wang X, Stemerman MB, Zhu Y, Shyy JY. PMID: 15358760.
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    83. Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection. Circulation. 2004 Sep 07; 110(10):1296-302. Lee TS, Chang CC, Zhu Y, Shyy JY. PMID: 15337692.
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    84. Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells. Circulation. 2004 Aug 31; 110(9):1128-33. Liu Y, Zhu Y, Rannou F, Lee TS, Formentin K, Zeng L, Yuan X, Wang N, Chien S, Forman BM, Shyy JY. PMID: 15313948.
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    85. Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis. Circ Res. 2004 Sep 03; 95(5):471-8. Zhou RH, Yao M, Lee TS, Zhu Y, Martins-Green M, Shyy JY. PMID: 15271857.
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    86. Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. Am J Pathol. 2004 Mar; 164(3):915-24. Rannou F, Lee TS, Zhou RH, Chin J, Lotz JC, Mayoux-Benhamou MA, Barbet JP, Chevrot A, Shyy JY. PMID: 14982845.
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    87. ATF6 modulates SREBP2-mediated lipogenesis. EMBO J. 2004 Feb 25; 23(4):950-8. Zeng L, Lu M, Mori K, Luo S, Lee AS, Zhu Y, Shyy JY. PMID: 14765107.
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    88. Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H685-92. Wang Y, Chang J, Li YC, Li YS, Shyy JY, Chien S. PMID: 14551058.
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    89. Stent implantation activates Akt in the vessel wall: role of mechanical stretch in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2003 Nov 01; 23(11):2015-20. Zhou RH, Lee TS, Tsou TC, Rannou F, Li YS, Chien S, Shyy JY. PMID: 12969991.
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    90. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res. 2003 Jun 27; 92(12):1296-304. Lin T, Zeng L, Liu Y, DeFea K, Schwartz MA, Chien S, Shyy JY. PMID: 12775580.
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    91. The role of p53 deacetylation in p21Waf1 regulation by laminar flow. J Biol Chem. 2003 Jul 04; 278(27):24594-9. Zeng L, Zhang Y, Chien S, Liu X, Shyy JY. PMID: 12716906.
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    92. Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol. 2002 Nov; 283(5):C1540-7. Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy JY, Chien S. PMID: 12372815.
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    93. Role of integrins in endothelial mechanosensing of shear stress. Circ Res. 2002 Nov 01; 91(9):769-75. Shyy JY, Chien S. PMID: 12411390.
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    94. Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray. J Vasc Surg. 2002 Aug; 36(2):379-85. Yajima N, Masuda M, Miyazaki M, Nakajima N, Chien S, Shyy JY. PMID: 12170221.
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    95. Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci. 2002 May 15; 115(Pt 10):2199-206. Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy JY, Takada Y, Usami S, Chien S. PMID: 11973360.
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    96. Induction of apoptosis in vascular smooth muscle cells by mechanical stretch. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1709-16. Sotoudeh M, Li YS, Yajima N, Chang CC, Tsou TC, Wang Y, Usami S, Ratcliffe A, Chien S, Shyy JY. PMID: 11959635.
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    97. Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):76-81. Liu Y, Chen BP, Lu M, Zhu Y, Stemerman MB, Chien S, Shyy JY. PMID: 11788464.
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    98. DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress. Physiol Genomics. 2001 Oct 10; 7(1):55-63. Chen BP, Li YS, Zhao Y, Chen KD, Li S, Lao J, Yuan S, Shyy JY, Chien S. PMID: 11595792.
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    99. LDL-activated p38 in endothelial cells is mediated by Ras. Arterioscler Thromb Vasc Biol. 2001 Jul; 21(7):1159-64. Zhu Y, Liao H, Wang N, Ma KS, Verna LK, Shyy JY, Chien S, Stemerman MB. PMID: 11451745.
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    100. Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1042-6. Jalali S, del Pozo MA, Chen K, Miao H, Li Y, Schwartz MA, Shyy JY, Chien S. PMID: 11158591.
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    101. Mechanotransduction in endothelial responses to shear stress: review of work in Dr. Chien's laboratory. Biorheology. 2001; 38(2-3):109-17. Shyy JY. PMID: 11381169.
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    102. Effects of active and negative mutants of Ras on rat arterial neointima formation. J Surg Res. 2000 Dec; 94(2):124-32. Jin G, Chieh-Hsi Wu J, Li YS, Hu YL, Shyy JY, Chien S. PMID: 11104652.
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    103. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. J Orthop Res. 2000 Nov; 18(6):899-908. Jin G, Sah RL, Li YS, Lotz M, Shyy JY, Chien S. PMID: 11192249.
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    104. Molecular mechanism of endothelial growth arrest by laminar shear stress. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9385-9. Lin K, Hsu PP, Chen BP, Yuan S, Usami S, Shyy JY, Li YS, Chien S. PMID: 10920209.
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    105. Mechanical compression modulates proliferation of transplanted chondrocytes. J Orthop Res. 2000 May; 18(3):374-82. Li KW, Falcovitz YH, Nagrampa JP, Chen AC, Lottman LM, Shyy JY, Sah RL. PMID: 10937623.
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    106. Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress. Am J Physiol. 1999 10; 277(4):H1593-9. Hu YL, Li S, Shyy JY, Chien S. PMID: 10516199.
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    107. Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. J Biol Chem. 1999 Jun 25; 274(26):18393-400. Chen KD, Li YS, Kim M, Li S, Yuan S, Chien S, Shyy JY. PMID: 10373445.
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    108. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. J Clin Invest. 1999 Apr; 103(8):1141-50. Li S, Chen BP, Azuma N, Hu YL, Wu SZ, Sumpio BE, Shyy JY, Chien S. PMID: 10207166.
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    109. Fluid shear stress activation of IkappaB kinase is integrin-dependent. J Biol Chem. 1998 Nov 13; 273(46):30544-9. Bhullar IS, Li YS, Miao H, Zandi E, Kim M, Shyy JY, Chien S. PMID: 9804824.
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    110. Effects of hemodynamic forces on gene expression and signal transduction in endothelial cells. Biol Bull. 1998 Jun; 194(3):390-1; discussion 392-3. Chien S, Shyy JY. PMID: 9664671.
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    111. A strain device imposing dynamic and uniform equi-biaxial strain to cultured cells. Ann Biomed Eng. 1998 Mar-Apr; 26(2):181-9. Sotoudeh M, Jalali S, Usami S, Shyy JY, Chien S. PMID: 9525759.
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    112. Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 1998 Feb; 18(2):227-34. Jalali S, Li YS, Sotoudeh M, Yuan S, Li S, Chien S, Shyy JY. PMID: 9484987.
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    113. Reactive oxygen species are involved in shear stress-induced intercellular adhesion molecule-1 expression in endothelial cells. Arterioscler Thromb Vasc Biol. 1997 Dec; 17(12):3570-7. Chiu JJ, Wung BS, Shyy JY, Hsieh HJ, Wang DL. PMID: 9437207.
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    114. Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem. 1997 Nov 28; 272(48):30455-62. Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JY. PMID: 9374537.
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    115. Role of integrins in cellular responses to mechanical stress and adhesion. Curr Opin Cell Biol. 1997 Oct; 9(5):707-13. Shyy JY, Chien S. PMID: 9330875.
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    116. Nitric oxide regulates monocyte chemotactic protein-1. Circulation. 1997 Aug 05; 96(3):934-40. Tsao PS, Wang B, Buitrago R, Shyy JY, Cooke JP. PMID: 9264504.
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    117. Shear stress induction of the tissue factor gene. J Clin Invest. 1997 Feb 15; 99(4):737-44. Lin MC, Almus-Jacobs F, Chen HH, Parry GC, Mackman N, Shyy JY, Chien S. PMID: 9045878.
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    118. The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol. 1996 Nov; 16(11):5947-54. Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S. PMID: 8887624.
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    119. Multiple cis-elements mediate shear stress-induced gene expression. J Biomech. 1995 Dec; 28(12):1451-7. Shyy JY, Li YS, Lin MC, Chen W, Yuan S, Usami S, Chien S. PMID: 8666585.
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    120. The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):8069-73. Shyy JY, Lin MC, Han J, Lu Y, Petrime M, Chien S. PMID: 7644539.
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