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    John Shyy

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0613K
    CA La Jolla 92093
    Phone858-534-3736
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Flow-Induced Endothelial Innate Immunity and Atherosclerosis Susceptibility
      NIH/NHLBI R01HL125643Aug 5, 2016 - Jul 31, 2020
      Role: Principal Investigator
      Systems Biology Analyses for Hemodynamic Regulation of Vascular Homeostasis
      NIH/NHLBI R01HL108735Aug 24, 2012 - Jun 30, 2021
      Role: Principal Investigator
      The miRNA-mediated Translational De-suppression in Hypoxic Endothelium
      NIH/NHLBI R21HL106567Aug 21, 2012 - May 31, 2015
      Role: Principal Investigator
      Shear Regulation of MicroRNA Transportomes and Targetomes in Vascular Homeostasis
      NIH/NHLBI R01HL106579Jan 1, 2011 - Nov 30, 2018
      Role: Principal Investigator
      Shear stress, SIRT1, and Arterial Stiffening
      NIH/NHLBI R01HL105318Sep 20, 2010 - Jun 30, 2015
      Role: Principal Investigator
      Adiponetin and AMPK Biosensor
      NIH/NHLBI R21HL093731Jul 1, 2009 - Jun 30, 2011
      Role: Principal Investigator
      Shear Stress, AMPK, and Endothelial Functions
      NIH/NHLBI R01HL089940Jan 1, 2009 - Dec 31, 2013
      Role: Principal Investigator
      Flow Regulation of SREBP in Atherosclerosis
      NIH/NHLBI R01HL077448Jul 1, 2004 - Apr 30, 2009
      Role: Principal Investigator
      STRAIN INDUCTION OF VSMC PROLIFERATION AND APOPTOSIS
      NIH/NHLBI R01HL060789Jul 1, 1998 - Jun 30, 2003
      Role: Principal Investigator
      SHEAR STRESS ENHANCEMENT OF SMOOTH MUSCLE CELL MIGRATION
      NIH/NHLBI R01HL056707Jul 1, 1996 - Jun 30, 2005
      Role: Principal Investigator
      MOLECULAR BASIS OF THE ENDOTHELIAL SHEAR STRESS RECEPTOR
      NIH/NHLBI R29HL056707Jul 1, 1996 - Jun 30, 2000
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, Huang HD, Jain M, Jain MK, Subramaniam S, Shyy J. KLF4 Regulation of Ch25h and LXR Mitigates Atherosclerosis Susceptibility. Circulation. 2017 Aug 09. PMID: 28794002.
        View in: PubMed
      2. Shang F, Wang SC, Hsu CY, Miao Y, Martin M, Yin Y, Wu CC, Wang YT, Wu G, Chien S, Huang HD, Tarng DC, Shiu YT, Cheung AK, Huang PH, Chen Z, Shyy J. MicroRNA-92a Mediates Endothelial Dysfunction in CKD. J Am Soc Nephrol. 2017 Jul 10. PMID: 28696247.
        View in: PubMed
      3. Bai L, Li Z, Li Q, Guan H, Zhao S, Liu R, Wang R, Zhang J, Jia Y, Fan J, Wang N, Reddy JK, Shyy J, Liu E. Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization. Arterioscler Thromb Vasc Biol. 2017 Aug; 37(8):1470-1481. PMID: 28642237.
        View in: PubMed
      4. Huang TS, Wang KC, Quon S, Nguyen P, Chang TY, Chen Z, Li YS, Subramaniam S, Shyy J, Chien S. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiol Genomics. 2017 Jul 01; 49(7):339-345. PMID: 28500253.
        View in: PubMed
      5. Chen Z, Li S, Subramaniam S, Shyy J, Chien S. Epigenetic Regulation: A New Frontier for Biomedical Engineers. Annu Rev Biomed Eng. 2017 Jun 21; 19:195-219. PMID: 28301736.
        View in: PubMed
      6. Marin TL, Gongol B, Zhang F, Martin M, Johnson DA, Xiao H, Wang Y, Subramaniam S, Chien S, Shyy J. AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1. Sci Signal. 2017 Jan 31; 10(464). PMID: 28143904.
        View in: PubMed
      7. Lin TY, Wei TW, Li S, Wang SC, He M, Martin M, Zhang J, Shentu TP, Xiao H, Kang J, Wang KC, Chen Z, Chien S, Tsai MD, Shyy J. TIFA as a crucial mediator for NLRP3 inflammasome. Proc Natl Acad Sci U S A. 2016 Dec 13. PMID: 27965388.
        View in: PubMed
      8. He M, Chen Z, Martin M, Zhang J, Sangwung P, Woo B, Tremoulet A, Shimizu C, Jain MK, Burns JC, Shyy J. miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. Circ Res. 2016 Dec 06. PMID: 27923814.
        View in: PubMed
      9. Miller YI, Shyy J. Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation. Trends Endocrinol Metab. 2016 Dec 05. PMID: 27931771.
        View in: PubMed
      10. Shentu TP, He M, Sun X, Zhang J, Zhang F, Gongol B, Marin TL, Zhang J, Wen L, Wang Y, Geary GG, Zhu Y, Johnson DA, Shyy J. AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function. Arterioscler Thromb Vasc Biol. 2016 Oct 6. PMID: 27758765.
        View in: PubMed
      11. Lin TC, Su CY, Wu PY, Lai TC, Pan WA, Jan YH, Chang YC, Yeh CT, Chen CL, Ger LP, Chang HT, Yang CJ, Huang MS, Liu YP, Lin YF, Shyy J, Tsai MD, Hsiao M. The nucleolar protein NIFK promotes cancer progression via CK1a/ß-catenin in metastasis and Ki-67-dependent cell proliferation. Elife. 2016; 5. PMID: 26984280.
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      12. Shang F, Zhang J, Li Z, Zhang J, Yin Y, Wang Y, Marin TL, Gongol B, Xiao H, Zhang YY, Chen Z, Shyy J, Lei T. Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. PLoS One. 2016; 11(3):e0151845. PMID: 26986624.
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      13. Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy J, Zhu Y. Activation of integrin a5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):769-74. PMID: 26733684.
        View in: PubMed
      14. Marin TL, Gongol B, Martin M, King SJ, Smith L, Johnson DA, Subramaniam S, Chien S, Shyy J. Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome. BMC Syst Biol. 2015; 9(1):13. PMID: 25890336.
        View in: PubMed
      15. Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy J. Oxidative Stress Activates Endothelial Innate Immunity via Sterol Regulatory Element Binding Protein 2 (SREBP2) Transactivation of MicroRNA-92a. Circulation. 2015 Mar 3; 131(9):805-14. PMID: 25550450.
        View in: PubMed
      16. Chen Z, Martin M, Li Z, Shyy J. Endothelial dysfunction: the role of sterol regulatory element-binding protein-induced NOD-like receptor family pyrin domain-containing protein 3 inflammasome in atherosclerosis. Curr Opin Lipidol. 2014 Oct; 25(5):339-49. PMID: 25188917.
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      17. Wang X, Fang X, Zhou J, Chen Z, Zhao B, Xiao L, Liu A, Li YS, Shyy J, Guan Y, Chien S, Wang N. Shear stress activation of nuclear receptor PXR in endothelial detoxification. Proc Natl Acad Sci U S A. 2013 Aug 6; 110(32):13174-9. PMID: 23878263.
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      18. Xiao H, Lu M, Lin TY, Chen Z, Chen G, Wang WC, Marin T, Shentu TP, Wen L, Gongol B, Sun W, Liang X, Chen J, Huang HD, Pedra JH, Johnson DA, Shyy J. Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility. Circulation. 2013 Aug 6; 128(6):632-42. PMID: 23838163.
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      19. Wen L, Chen Z, Zhang F, Cui X, Sun W, Geary GG, Wang Y, Johnson DA, Zhu Y, Chien S, Shyy J. Ca2+/calmodulin-dependent protein kinase kinase ß phosphorylation of Sirtuin 1 in endothelium is atheroprotective. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2420-7. PMID: 23754392.
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      20. Marin T, Gongol B, Chen Z, Woo B, Subramaniam S, Chien S, Shyy J. Mechanosensitive microRNAs-role in endothelial responses to shear stress and redox state. Free Radic Biol Med. 2013 Sep; 64:61-8. PMID: 23727269.
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      21. Chen Z, Shentu TP, Wen L, Johnson DA, Shyy J. Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium. Antioxid Redox Signal. 2013 Nov 1; 19(13):1522-38. PMID: 23477488.
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      22. Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, Chiu JJ, Shyy J, Chien S. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013 Jun 21; 113(1):40-51. PMID: 23603512.
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      23. He M, Liang X, He L, Wen W, Zhao S, Wen L, Liu Y, Shyy J, Yuan Z. Endothelial dysfunction in rheumatoid arthritis: the role of monocyte chemotactic protein-1-induced protein. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1384-91. PMID: 23580143.
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      24. Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy J, Huang Y, Wang N. Response to overexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation. Hypertension. 2013 Apr; 61(4):e30. PMID: 23607134.
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      25. Chen Z, Lai TC, Jan YH, Lin FM, Wang WC, Xiao H, Wang YT, Sun W, Cui X, Li YS, Fang T, Zhao H, Padmanabhan C, Sun R, Wang DL, Jin H, Chau GY, Huang HD, Hsiao M, Shyy J. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J Clin Invest. 2013 Mar 1; 123(3):1057-67. PMID: 23426184.
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      26. Gongol B, Marin T, Peng IC, Woo B, Martin M, King S, Sun W, Johnson DA, Chien S, Shyy J. AMPKa2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3161-6. PMID: 23382195.
        View in: PubMed
      27. Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy J, Huang Y, Wang N. Peroxisome proliferator-activated receptor-? ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor. Hypertension. 2012 Dec; 60(6):1471-8. PMID: 23108648.
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      28. Chen HY, Lin YM, Chung HC, Lang YD, Lin CJ, Huang J, Wang WC, Lin FM, Chen Z, Huang HD, Shyy J, Liang JT, Chen RH. miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. Cancer Res. 2012 Jul 15; 72(14):3631-41. PMID: 22593189.
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      29. Huang CC, Weng JH, Wei TY, Wu PY, Hsu PH, Chen YH, Wang SC, Qin D, Hung CC, Chen ST, Wang AH, Shyy J, Tsai MD. Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-?B activation. Mol Cell Biol. 2012 Jul; 32(14):2664-73. PMID: 22566686.
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      30. Vandrangi P, Sosa M, Shyy J, Rodgers VG. Flow-dependent mass transfer may trigger endothelial signaling cascades. PLoS One. 2012; 7(4):e35260. PMID: 22558132.
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      31. Peng IC, Chen Z, Sun W, Li YS, Marin TL, Hsu PH, Su MI, Cui X, Pan S, Lytle CY, Johnson DA, Blaeser F, Chatila T, Shyy J. Glucagon regulates ACC activity in adipocytes through the CAMKKß/AMPK pathway. Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1560-8. PMID: 22454291.
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      32. Wu W, Xiao H, Laguna-Fernandez A, Villarreal G, Wang KC, Geary GG, Zhang Y, Wang WC, Huang HD, Zhou J, Li YS, Chien S, Garcia-Cardena G, Shyy J. Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation. 2011 Aug 2; 124(5):633-41. PMID: 21768538.
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      33. Zhou J, Wang KC, Wu W, Subramaniam S, Shyy J, Chiu JJ, Li JY, Chien S. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10355-60. PMID: 21636785.
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      34. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy J, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011 Apr 6; 13(4):376-88. PMID: 21459323.
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      35. Fu Y, Hou Y, Fu C, Gu M, Li C, Kong W, Wang X, Shyy J, Zhu Y. A novel mechanism of ?/d T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase ß chain. Circ Res. 2011 Feb 18; 108(4):410-7. PMID: 21193741.
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      36. Lin CT, Tang HY, Han YS, Liu HP, Huang SF, Chien CH, Shyy J, Chiu JJ, Chen X. Downregulation of Signaling-active IGF-1 by Dipeptidyl Peptidase IV (DPP-IV). Int J Biomed Sci. 2010 Dec; 6(4):301-9. PMID: 23675206.
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      37. Zheng S, Li W, Xu M, Bai X, Zhou Z, Han J, Shyy J, Wang X. Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1485-92. PMID: 20881236.
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      38. Wang P, Jiang Y, Wang Y, Shyy J, DeFea KA. Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2. BMC Biochem. 2010; 11:36. PMID: 20858278.
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      39. Sun W, Julie Li YS, Huang HD, Shyy J, Chien S. microRNA: a master regulator of cellular processes for bioengineering systems. Annu Rev Biomed Eng. 2010 Aug 15; 12:1-27. PMID: 20415587.
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      40. Chen Z, Peng IC, Cui X, Li YS, Chien S, Shyy J. Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A. 2010 Jun 1; 107(22):10268-73. PMID: 20479254.
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      41. Fu C, He J, Li C, Shyy J, Zhu Y. Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae. Biochim Biophys Acta. 2010 Jul; 1801(7):702-10. PMID: 20382259.
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      42. Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang N, Shyy J, Li YS, Chien S. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3234-9. PMID: 20133741.
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      43. Ai D, Shyy J, Zhu Y. Linking an insect enzyme to hypertension: angiotensin II-epoxide hydrolase interactions. Kidney Int. 2010 Jan; 77(2):88-92. PMID: 19847158.
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      44. Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy J, Chien S, García-Cardeña G. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1902-8. PMID: 19696400.
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      45. Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, Czernin J, Shyy J, Watson AD, Phelps M, Radu CG, Cloughesy TF, Mischel PS. The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci U S A. 2009 Aug 4; 106(31):12932-7. PMID: 19625624.
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      46. Yuan H, Shyy J, Martins-Green M. Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1. J Hepatol. 2009 Sep; 51(3):535-47. PMID: 19556020.
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      47. Shyy J. Extracellular matrix differentiating good flow versus bad flow. Circ Res. 2009 Apr 24; 104(8):931-2. PMID: 19390061.
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      48. Xie X, Liao H, Dang H, Pang W, Guan Y, Wang X, Shyy J, Zhu Y, Sladek FM. Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs. Mol Endocrinol. 2009 Apr; 23(4):434-43. PMID: 19179483.
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      49. Chen Z, Peng IC, Sun W, Su MI, Hsu PH, Fu Y, Zhu Y, DeFea K, Pan S, Tsai MD, Shyy J. AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res. 2009 Feb 27; 104(4):496-505. PMID: 19131647.
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      50. Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy J, Hammock BD, Zhu Y. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):564-9. PMID: 19126686.
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      51. Dang H, Liu Y, Pang W, Li C, Wang N, Shyy J, Zhu Y. Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. J Biol Chem. 2009 Mar 6; 284(10):6218-26. PMID: 19119143.
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      52. Li X, Han Y, Pang W, Li C, Xie X, Shyy J, Zhu Y. AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2008 Oct; 28(10):1789-95. PMID: 18599796.
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      53. Ouyang M, Lu S, Li XY, Xu J, Seong J, Giepmans BN, Shyy J, Weiss SJ, Wang Y. Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging. J Biol Chem. 2008 Jun 20; 283(25):17740-8. PMID: 18441011.
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      54. Wang Y, Shyy J, Chien S. Fluorescence proteins, live-cell imaging, and mechanobiology: seeing is believing. Annu Rev Biomed Eng. 2008; 10:1-38. PMID: 18647110.
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      55. Zhu M, Fu Y, Hou Y, Wang N, Guan Y, Tang C, Shyy J, Zhu Y. Laminar shear stress regulates liver X receptor in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):527-33. PMID: 18096827.
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      56. Benallaoua M, François M, Batteux F, Thelier N, Shyy J, Fitting C, Tsagris L, Boczkowski J, Savouret JF, Corvol MT, Poiraudeau S, Rannou F. Pharmacologic induction of heme oxygenase 1 reduces acute inflammatory arthritis in mice. Arthritis Rheum. 2007 Aug; 56(8):2585-94. PMID: 17665394.
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      57. Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy J, Zhu Y. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):9018-23. PMID: 17495027.
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      58. Guo D, Chien S, Shyy J. Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and Akt pathways. Circ Res. 2007 Mar 2; 100(4):564-71. PMID: 17272808.
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      59. Sun W, Lee TS, Zhu M, Gu C, Wang Y, Zhu Y, Shyy J. Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation. 2006 Dec 12; 114(24):2655-62. PMID: 17116771.
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      60. Wang T, Chen Z, Wang X, Shyy J, Zhu Y. Cholesterol loading increases the translocation of ATP synthase beta chain into membrane caveolae in vascular endothelial cells. Biochim Biophys Acta. 2006 Oct; 1761(10):1182-90. PMID: 16996794.
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      61. Yao M, Zhou RH, Petreaca M, Zheng L, Shyy J, Martins-Green M. Activation of sterol regulatory element-binding proteins (SREBPs) is critical in IL-8-induced angiogenesis. J Leukoc Biol. 2006 Sep; 80(3):608-20. PMID: 16849610.
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      62. Lu M, Shyy J. Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation. Am J Physiol Cell Physiol. 2006 Jun; 290(6):C1477-86. PMID: 16381800.
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      63. Liu Y, Zhang Y, Schmelzer K, Lee TS, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy J. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16747-52. PMID: 16267130.
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      64. Zhu Y, Liao H, Xie X, Yuan Y, Lee TS, Wang N, Wang X, Shyy J, Stemerman MB. Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). Cardiovasc Res. 2005 Dec 1; 68(3):425-32. PMID: 16099444.
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      65. Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy J, Hammock BD, Spector AA. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther. 2005 Jul; 314(1):260-70. PMID: 15798002.
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      66. Yeh M, Cole AL, Choi J, Liu Y, Tulchinsky D, Qiao JH, Fishbein MC, Dooley AN, Hovnanian T, Mouilleseaux K, Vora DK, Yang WP, Gargalovic P, Kirchgessner T, Shyy J, Berliner JA. Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products. Circ Res. 2004 Oct 15; 95(8):780-8. PMID: 15388640.
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      67. Zeng L, Liao H, Liu Y, Lee TS, Zhu M, Wang X, Stemerman MB, Zhu Y, Shyy J. Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J Biol Chem. 2004 Nov 19; 279(47):48801-7. PMID: 15358760.
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      68. Lee TS, Chang CC, Zhu Y, Shyy J. Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection. Circulation. 2004 Sep 7; 110(10):1296-302. PMID: 15337692.
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      69. Liu Y, Zhu Y, Rannou F, Lee TS, Formentin K, Zeng L, Yuan X, Wang N, Chien S, Forman BM, Shyy J. Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells. Circulation. 2004 Aug 31; 110(9):1128-33. PMID: 15313948.
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      70. Zhou RH, Yao M, Lee TS, Zhu Y, Martins-Green M, Shyy J. Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis. Circ Res. 2004 Sep 3; 95(5):471-8. PMID: 15271857.
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      71. Rannou F, Lee TS, Zhou RH, Chin J, Lotz JC, Mayoux-Benhamou MA, Barbet JP, Chevrot A, Shyy J. Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. Am J Pathol. 2004 Mar; 164(3):915-24. PMID: 14982845.
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      72. Zeng L, Lu M, Mori K, Luo S, Lee AS, Zhu Y, Shyy J. ATF6 modulates SREBP2-mediated lipogenesis. EMBO J. 2004 Feb 25; 23(4):950-8. PMID: 14765107.
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      73. Wang Y, Chang J, Li YC, Li YS, Shyy J, Chien S. Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H685-92. PMID: 14551058.
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      74. Zhou RH, Lee TS, Tsou TC, Rannou F, Li YS, Chien S, Shyy J. Stent implantation activates Akt in the vessel wall: role of mechanical stretch in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2003 Nov 1; 23(11):2015-20. PMID: 12969991.
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      75. Lin T, Zeng L, Liu Y, DeFea K, Schwartz MA, Chien S, Shyy J. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res. 2003 Jun 27; 92(12):1296-304. PMID: 12775580.
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      76. Zeng L, Zhang Y, Chien S, Liu X, Shyy J. The role of p53 deacetylation in p21Waf1 regulation by laminar flow. J Biol Chem. 2003 Jul 4; 278(27):24594-9. PMID: 12716906.
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      77. Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy J, Chien S. Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol. 2002 Nov; 283(5):C1540-7. PMID: 12372815.
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      78. Shyy J, Chien S. Role of integrins in endothelial mechanosensing of shear stress. Circ Res. 2002 Nov 1; 91(9):769-75. PMID: 12411390.
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      79. Yajima N, Masuda M, Miyazaki M, Nakajima N, Chien S, Shyy J. Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray. J Vasc Surg. 2002 Aug; 36(2):379-85. PMID: 12170221.
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      80. Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy J, Takada Y, Usami S, Chien S. Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci. 2002 May 15; 115(Pt 10):2199-206. PMID: 11973360.
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      81. Sotoudeh M, Li YS, Yajima N, Chang CC, Tsou TC, Wang Y, Usami S, Ratcliffe A, Chien S, Shyy J. Induction of apoptosis in vascular smooth muscle cells by mechanical stretch. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1709-16. PMID: 11959635.
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      82. Liu Y, Chen BP, Lu M, Zhu Y, Stemerman MB, Chien S, Shyy J. Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):76-81. PMID: 11788464.
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      83. Chen BP, Li YS, Zhao Y, Chen KD, Li S, Lao J, Yuan S, Shyy J, Chien S. DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress. Physiol Genomics. 2001 Oct 10; 7(1):55-63. PMID: 11595792.
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      84. Zhu Y, Liao H, Wang N, Ma KS, Verna LK, Shyy J, Chien S, Stemerman MB. LDL-activated p38 in endothelial cells is mediated by Ras. Arterioscler Thromb Vasc Biol. 2001 Jul; 21(7):1159-64. PMID: 11451745.
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      85. Jalali S, del Pozo MA, Chen K, Miao H, Li Y, Schwartz MA, Shyy J, Chien S. Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1042-6. PMID: 11158591.
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      86. Shyy J. Mechanotransduction in endothelial responses to shear stress: review of work in Dr. Chien's laboratory. Biorheology. 2001; 38(2-3):109-17. PMID: 11381169.
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      87. Jin G, Chieh-Hsi Wu J, Li YS, Hu YL, Shyy J, Chien S. Effects of active and negative mutants of Ras on rat arterial neointima formation. J Surg Res. 2000 Dec; 94(2):124-32. PMID: 11104652.
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      88. Jin G, Sah RL, Li YS, Lotz M, Shyy J, Chien S. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. J Orthop Res. 2000 Nov; 18(6):899-908. PMID: 11192249.
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      89. Lin K, Hsu PP, Chen BP, Yuan S, Usami S, Shyy J, Li YS, Chien S. Molecular mechanism of endothelial growth arrest by laminar shear stress. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9385-9. PMID: 10920209.
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      90. Li KW, Falcovitz YH, Nagrampa JP, Chen AC, Lottman LM, Shyy J, Sah RL. Mechanical compression modulates proliferation of transplanted chondrocytes. J Orthop Res. 2000 May; 18(3):374-82. PMID: 10937623.
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      91. Hu YL, Li S, Shyy J, Chien S. Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress. Am J Physiol. 1999 Oct; 277(4 Pt 2):H1593-9. PMID: 10516199.
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      92. Chen KD, Li YS, Kim M, Li S, Yuan S, Chien S, Shyy J. Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. J Biol Chem. 1999 Jun 25; 274(26):18393-400. PMID: 10373445.
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      93. Li S, Chen BP, Azuma N, Hu YL, Wu SZ, Sumpio BE, Shyy J, Chien S. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. J Clin Invest. 1999 Apr; 103(8):1141-50. PMID: 10207166.
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      94. Bhullar IS, Li YS, Miao H, Zandi E, Kim M, Shyy J, Chien S. Fluid shear stress activation of IkappaB kinase is integrin-dependent. J Biol Chem. 1998 Nov 13; 273(46):30544-9. PMID: 9804824.
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      95. Chien S, Shyy J. Effects of hemodynamic forces on gene expression and signal transduction in endothelial cells. Biol Bull. 1998 Jun; 194(3):390-1; discussion 392-3. PMID: 9664671.
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      96. Sotoudeh M, Jalali S, Usami S, Shyy J, Chien S. A strain device imposing dynamic and uniform equi-biaxial strain to cultured cells. Ann Biomed Eng. 1998 Mar-Apr; 26(2):181-9. PMID: 9525759.
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      97. Jalali S, Li YS, Sotoudeh M, Yuan S, Li S, Chien S, Shyy J. Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 1998 Feb; 18(2):227-34. PMID: 9484987.
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      98. Chiu JJ, Wung BS, Shyy J, Hsieh HJ, Wang DL. Reactive oxygen species are involved in shear stress-induced intercellular adhesion molecule-1 expression in endothelial cells. Arterioscler Thromb Vasc Biol. 1997 Dec; 17(12):3570-7. PMID: 9437207.
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      99. Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy J. Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem. 1997 Nov 28; 272(48):30455-62. PMID: 9374537.
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      100. Shyy J, Chien S. Role of integrins in cellular responses to mechanical stress and adhesion. Curr Opin Cell Biol. 1997 Oct; 9(5):707-13. PMID: 9330875.
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      101. Tsao PS, Wang B, Buitrago R, Shyy J, Cooke JP. Nitric oxide regulates monocyte chemotactic protein-1. Circulation. 1997 Aug 5; 96(3):934-40. PMID: 9264504.
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      102. Lin MC, Almus-Jacobs F, Chen HH, Parry GC, Mackman N, Shyy J, Chien S. Shear stress induction of the tissue factor gene. J Clin Invest. 1997 Feb 15; 99(4):737-44. PMID: 9045878.
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      103. Li YS, Shyy J, Li S, Lee J, Su B, Karin M, Chien S. The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol. 1996 Nov; 16(11):5947-54. PMID: 8887624.
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      104. Shyy J, Li YS, Lin MC, Chen W, Yuan S, Usami S, Chien S. Multiple cis-elements mediate shear stress-induced gene expression. J Biomech. 1995 Dec; 28(12):1451-7. PMID: 8666585.
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      105. Shyy J, Lin MC, Han J, Lu Y, Petrime M, Chien S. The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):8069-73. PMID: 7644539.
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