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John Shyy

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emailjshyy@ucsd.edu
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    Collapse Research 
    Collapse research activities and funding
    Innate Immune Activation and Endothelial Cell Dysfunction in Acute Kawasaki Disease
    NIH R01HL140898Jan 1, 2018 - Nov 30, 2022
    Role: Co-Principal Investigator
    Flow-Induced Endothelial Innate Immunity and Atherosclerosis Susceptibility
    NIH R01HL125643Aug 5, 2016 - Jul 31, 2020
    Role: Principal Investigator
    Systems Biology Analyses for Hemodynamic Regulation of Vascular Homeostasis
    NIH R01HL108735Aug 24, 2012 - Jul 31, 2025
    Role: Principal Investigator
    The miRNA-mediated Translational De-suppression in Hypoxic Endothelium
    NIH R21HL106567Aug 21, 2012 - May 31, 2015
    Role: Principal Investigator
    Nucleolin Regulation of miRome by Shear Stress
    NIH R01HL106579Jan 1, 2011 - Nov 30, 2022
    Role: Principal Investigator
    Shear stress, SIRT1, and Arterial Stiffening
    NIH R01HL105318Sep 20, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Adiponetin and AMPK Biosensor
    NIH R21HL093731Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Shear Stress, AMPK, and Endothelial Functions
    NIH R01HL089940Jan 1, 2009 - Dec 31, 2013
    Role: Principal Investigator
    Flow Regulation of SREBP in Atherosclerosis
    NIH R01HL077448Jul 1, 2004 - Apr 30, 2009
    Role: Principal Investigator
    STRAIN INDUCTION OF VSMC PROLIFERATION AND APOPTOSIS
    NIH R01HL060789Jul 1, 1998 - Jun 30, 2003
    Role: Principal Investigator
    SHEAR STRESS ENHANCEMENT OF SMOOTH MUSCLE CELL MIGRATION
    NIH R01HL056707Jul 1, 1996 - Jun 30, 2005
    Role: Principal Investigator
    MOLECULAR BASIS OF THE ENDOTHELIAL SHEAR STRESS RECEPTOR
    NIH R29HL056707Jul 1, 1996 - Jun 30, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SOX17 Regulates Nestin/p16INK4a Axis to Mitigate Endothelial Senescence in Pulmonary Arterial Hypertension. Res Sq. 2025 Jul 29. Sun W, Wu T, Zhou Z, Jiang D, Wei TY, Han SY, Shyy J, Li G, Shi R. PMID: 40766215; PMCID: PMC12324586.
      View in: PubMed   Mentions:
    2. Pulsatile flow induces chromatin interaction with lamin-associated proteins to enrich H3K9 methylation in endothelial cells. Proc Natl Acad Sci U S A. 2025 Mar 25; 122(12):e2424566122. Chen LJ, Li JY, Nguyen P, Norwich G, Wang Y, Teng D, Shiu YT, Shyy JYJ, Chien S. PMID: 40117319; PMCID: PMC11962468.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. AMPK phosphorylation of KCa2.3 alleviates angiotensin II-induced endothelial dysfunction. Biochem Pharmacol. 2025 06; 236:116880. Pang ZD, Wang Y, Han MZ, She G, Sun X, Bai RY, Lai BC, Zhang Y, Du XJ, Shyy JY, Deng XL. PMID: 40112931.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Silencing KRIT1 Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell Transcriptome. bioRxiv. 2025 Mar 14. Meecham A, McCurdy S, Frias-Anaya E, Li W, Gallego-Gutierrez H, Ngyuen P, Li JY, Chien S, Shyy JY, Ginsberg MH, Lopez-Ramirez MA. PMID: 40161739; PMCID: PMC11952409.
      View in: PubMed   Mentions:
    5. Single-cell RNA sequencing unveils unique transcriptomic signatures of endothelial cells and role of ENO1 in response to disturbed flow. Proc Natl Acad Sci U S A. 2024 Jan 30; 121(5):e2318904121. Chen LJ, Li JY, Nguyen P, He M, Chen ZB, Subramaniam S, Shyy JY, Chien S. PMID: 38261622; PMCID: PMC10835041.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    6. Epitranscriptomic Modification of MicroRNA Increases Atherosclerosis Susceptibility. Circulation. 2023 11 28; 148(22):1819-1822. He M, Dong J, Wen J, Zhang Y, Han SY, Wang C, Gongol B, Wei TW, Kang J, Huang HY, Cheng S, Shyy JY. PMID: 38011244; PMCID: PMC10683863.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Endothelial Cell Response in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children. Int J Mol Sci. 2023 Aug 01; 24(15). Kim J, Shimizu C, He M, Wang H, Hoffman HM, Tremoulet AH, Shyy JY, Burns JC. PMID: 37569694; PMCID: PMC10418493.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Epitranscriptional Regulation: From the Perspectives of Cardiovascular Bioengineering. Annu Rev Biomed Eng. 2023 06 08; 25:157-184. Chen ZB, He M, Li JY, Shyy JY, Chien S. PMID: 36913673.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Time Domains of Hypoxia Responses and -Omics Insights. Front Physiol. 2022; 13:885295. Yu JJ, Non AL, Heinrich EC, Gu W, Alcock J, Moya EA, Lawrence ES, Tift MS, O'Brien KA, Storz JF, Signore AV, Khudyakov JI, Milsom WK, Wilson SM, Beall CM, Villafuerte FC, Stobdan T, Julian CG, Moore LG, Fuster MM, Stokes JA, Milner R, West JB, Zhang J, Shyy JY, Childebayeva A, Vázquez-Medina JP, Pham LV, Mesarwi OA, Hall JE, Cheviron ZA, Sieker J, Blood AB, Yuan JX, Scott GR, Rana BK, Ponganis PJ, Malhotra A, Powell FL, Simonson TS. PMID: 36035495; PMCID: PMC9400701.
      View in: PubMed   Mentions: 13  
    10. RNA Sequencing Reveals Beneficial Effects of Atorvastatin on Endothelial Cells in Acute Kawasaki Disease. J Am Heart Assoc. 2022 07 19; 11(14):e025408. Shimizu C, Kim J, He M, Tremoulet AH, Hoffman HM, Shyy JY, Burns JC. PMID: 35861833; PMCID: PMC9707837.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. JAGGED-NOTCH3 signaling in vascular remodeling in pulmonary arterial hypertension. Sci Transl Med. 2022 05 04; 14(643):eabl5471. Zhang Y, Hernandez M, Gower J, Winicki N, Morataya X, Alvarez S, Yuan JX, Shyy J, Thistlethwaite PA. PMID: 35507674.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    12. Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2022 05 01; 322(5):L737-L760. Chen J, Rodriguez M, Miao J, Liao J, Jain PP, Zhao M, Zhao T, Babicheva A, Wang Z, Parmisano S, Powers R, Matti M, Paquin C, Soroureddin Z, Shyy JY, Thistlethwaite PA, Makino A, Wang J, Yuan JX. PMID: 35318857; PMCID: PMC9076422.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    13. Role of endothelial cells in pulmonary fibrosis via SREBP2 activation. JCI Insight. 2021 11 22; 6(22). Martin M, Zhang J, Miao Y, He M, Kang J, Huang HY, Chou CH, Huang TS, Hong HC, Su SH, Wong SS, Harper RL, Wang L, Bhattacharjee R, Huang HD, Chen ZB, Malhotra A, Rabinovitch M, Hagood JS, Shyy JY. PMID: 34806652; PMCID: PMC8663776.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    14. TRPC6, a therapeutic target for pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 12 01; 321(6):L1161-L1182. Jain PP, Lai N, Xiong M, Chen J, Babicheva A, Zhao T, Parmisano S, Zhao M, Paquin C, Matti M, Powers R, Balistrieri A, Kim NH, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX. PMID: 34704831; PMCID: PMC8715021.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    15. Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension. Am J Physiol Cell Physiol. 2021 12 01; 321(6):C1010-C1027. Wang Z, Chen J, Babicheva A, Jain PP, Rodriguez M, Ayon RJ, Ravellette KS, Wu L, Balistrieri F, Tang H, Wu X, Zhao T, Black SM, Desai AA, Garcia JGN, Sun X, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Wang J, Yuan JX. PMID: 34669509; PMCID: PMC8714987.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    16. Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization. Pulm Circ. 2021 Oct-Dec; 11(4):20458940211041512. Xiong M, Jain PP, Chen J, Babicheva A, Zhao T, Alotaibi M, Kim NH, Lai N, Izadi A, Rodriguez M, Li J, Balistrieri A, Balistrieri F, Parmisano S, Sun X, Voldez-Jasso D, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. PMID: 34531976; PMCID: PMC8438952.
      View in: PubMed   Mentions: 6  
    17. Halofuginone, a promising drug for treatment of pulmonary hypertension. Br J Pharmacol. 2021 09; 178(17):3373-3394. Jain PP, Zhao T, Xiong M, Song S, Lai N, Zheng Q, Chen J, Carr SG, Babicheva A, Izadi A, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Simonson T, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Makino A, Yuan JX. PMID: 33694155; PMCID: PMC9792225.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    18. Inflammasome Activation in Children With Kawasaki Disease and Multisystem Inflammatory Syndrome. Arterioscler Thromb Vasc Biol. 2021 09; 41(9):2509-2511. Wang WT, He M, Shimizu C, Croker BA, Hoffman HM, Tremoulet AH, Burns JC, Shyy JY. PMID: 34261329; PMCID: PMC8387357.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    19. Roles of KLF4 and AMPK in the inhibition of glycolysis by pulsatile shear stress in endothelial cells. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). Han Y, He M, Marin T, Shen H, Wang WT, Lee TY, Hong HC, Jiang ZL, Garland T, Shyy JY, Gongol B, Chien S. PMID: 34001623; PMCID: PMC8166073.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    20. Inpatient Use of Metformin and Acarbose Is Associated with Reduced Mortality of COVID-19 Patients with Type 2 Diabetes Mellitus. Res Sq. 2021 Mar 26. Li W, Li J, Wei Q, McCowen K, Xiong W, Liu J, Jiang W, Thomas R, Hepokoski M, He M, Shyy J, Malhotra A, Xiong N. PMID: 33791691; PMCID: PMC8010742.
      View in: PubMed   Mentions:
    21. Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. FASEB Bioadv. 2021 May; 3(5):334-355. Lopez-Ramirez MA, McCurdy S, Li W, Haynes MK, Hale P, Francisco K, Oukoloff K, Bautista M, Choi CHJ, Sun H, Gongol B, Shyy JY, Ballatore C, Sklar LA, Gingras AR. PMID: 33977234; PMCID: PMC8103725.
      View in: PubMed   Mentions: 7  
    22. Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions. Proc Natl Acad Sci U S A. 2021 01 26; 118(4). Maurya MR, Gupta S, Li JY, Ajami NE, Chen ZB, Shyy JY, Chien S, Subramaniam S. PMID: 33468662; PMCID: PMC7848718.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    23. microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production. JCI Insight. 2020 12 03; 5(23). Dong J, He M, Li J, Pessentheiner A, Wang C, Zhang J, Sun Y, Wang WT, Zhang Y, Liu J, Wang SC, Huang PH, Gordts PL, Yuan ZY, Tsimikas S, Shyy JY. PMID: 33119548; PMCID: PMC7714402.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    24. Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nat Commun. 2020 11 30; 11(1):6088. Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J. PMID: 33257668; PMCID: PMC7705703.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    25. Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020956592. Jain PP, Hosokawa S, Xiong M, Babicheva A, Zhao T, Rodriguez M, Rahimi S, Pourhashemi K, Balistrieri F, Lai N, Malhotra A, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Yuan JX. PMID: 33282184; PMCID: PMC7691930.
      View in: PubMed   Mentions: 13  
    26. AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice. Biochem Pharmacol. 2021 01; 183:114337. Pang ZD, Wang Y, Song Z, She G, Ma XZ, Sun X, Wu W, Lai BC, Zhang J, Zhang Y, Du XJ, Shyy JYJ, Deng XL. PMID: 33186592.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    27. Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19. Endocr Pract. 2020 Oct; 26(10):1166-1172. Li J, Wei Q, Li WX, McCowen KC, Xiong W, Liu J, Jiang W, Marin T, Thomas RL, He M, Gongol B, Hepokoski M, Yuan JX, Shyy JY, Xiong N, Malhotra A. PMID: 33471718; PMCID: PMC7834011.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    28. Serum miR-92a is Elevated in Children and Adults with Obstructive Sleep Apnea. J Mol Biomark Diagn. 2020; 11(4). Gongol B, Shang F, He M, Zhao Y, Shi W, Cheng M, Shyy JY, Wang L, Malhotra A, Bhattacharjee R. PMID: 33425479; PMCID: PMC7789821.
      View in: PubMed   Mentions: 7  
    29. Shear stress regulation of miR-93 and miR-484 maturation through nucleolin. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):12974-12979. Gongol B, Marin T, Zhang J, Wang SC, Sun W, He M, Chen S, Chen L, Li J, Liu JH, Martin M, Han Y, Kang J, Johnson DA, Lytle C, Li YS, Huang PH, Chien S, Shyy JY. PMID: 31182601; PMCID: PMC6600934.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    30. Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications. Arterioscler Thromb Vasc Biol. 2019 05; 39(5):902-914. He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, Shyy JY. PMID: 30917677; PMCID: PMC6536300.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    31. Shear Stress Regulation of Endothelium: A Double-edged Sword. J Transl Int Med. 2018 Jun; 6(2):58-61. Bai L, Shyy JY. PMID: 29984197; PMCID: PMC6032189.
      View in: PubMed   Mentions: 9  
    32. Bioinformatics Approach to Identify Novel AMPK Targets. Methods Mol Biol. 2018; 1732:99-109. Gongol B, Marin T, Johnson DA, Shyy JY. PMID: 29480471.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    33. Systems biology analysis of longitudinal functional response of endothelial cells to shear stress. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):10990-10995. Ajami NE, Gupta S, Maurya MR, Nguyen P, Li JY, Shyy JY, Chen Z, Chien S, Subramaniam S. PMID: 28973892; PMCID: PMC5642700.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    34. Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. Circulation. 2017 Oct 03; 136(14):1315-1330. Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, Huang HD, Jain M, Jain MK, Subramaniam S, Shyy JY. PMID: 28794002; PMCID: PMC5741092.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimals
    35. MicroRNA-92a Mediates Endothelial Dysfunction in CKD. J Am Soc Nephrol. 2017 Nov; 28(11):3251-3261. Shang F, Wang SC, Hsu CY, Miao Y, Martin M, Yin Y, Wu CC, Wang YT, Wu G, Chien S, Huang HD, Tarng DC, Shiu YT, Cheung AK, Huang PH, Chen Z, Shyy JY. PMID: 28696247; PMCID: PMC5661278.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    36. Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization. Arterioscler Thromb Vasc Biol. 2017 08; 37(8):1470-1481. Bai L, Li Z, Li Q, Guan H, Zhao S, Liu R, Wang R, Zhang J, Jia Y, Fan J, Wang N, Reddy JK, Shyy JY, Liu E. PMID: 28642237; PMCID: PMC5739054.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    37. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiol Genomics. 2017 Jul 01; 49(7):339-345. Huang TS, Wang KC, Quon S, Nguyen P, Chang TY, Chen Z, Li YS, Subramaniam S, Shyy J, Chien S. PMID: 28500253; PMCID: PMC5538877.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    38. Epigenetic Regulation: A New Frontier for Biomedical Engineers. Annu Rev Biomed Eng. 2017 06 21; 19:195-219. Chen Z, Li S, Subramaniam S, Shyy JY, Chien S. PMID: 28301736.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    39. AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1. Sci Signal. 2017 01 31; 10(464). Marin TL, Gongol B, Zhang F, Martin M, Johnson DA, Xiao H, Wang Y, Subramaniam S, Chien S, Shyy JY. PMID: 28143904; PMCID: PMC5830108.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    40. TIFA as a crucial mediator for NLRP3 inflammasome. Proc Natl Acad Sci U S A. 2016 12 27; 113(52):15078-15083. Lin TY, Wei TW, Li S, Wang SC, He M, Martin M, Zhang J, Shentu TP, Xiao H, Kang J, Wang KC, Chen Z, Chien S, Tsai MD, Shyy JY. PMID: 27965388; PMCID: PMC5206521.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    41. miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. Circ Res. 2017 Jan 20; 120(2):354-365. He M, Chen Z, Martin M, Zhang J, Sangwung P, Woo B, Tremoulet AH, Shimizu C, Jain MK, Burns JC, Shyy JY. PMID: 27923814; PMCID: PMC5391835.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    42. Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation. Trends Endocrinol Metab. 2017 02; 28(2):143-152. Miller YI, Shyy JY. PMID: 27931771; PMCID: PMC5253098.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    43. AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function. Arterioscler Thromb Vasc Biol. 2016 12; 36(12):2358-2368. Shentu TP, He M, Sun X, Zhang J, Zhang F, Gongol B, Marin TL, Zhang J, Wen L, Wang Y, Geary GG, Zhu Y, Johnson DA, Shyy JY. PMID: 27758765; PMCID: PMC5391843.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    44. Activation of integrin α5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):769-74. Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy JY, Zhu Y. PMID: 26733684; PMCID: PMC4725528.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    45. Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome. BMC Syst Biol. 2015 Mar 11; 9:13. Marin TL, Gongol B, Martin M, King SJ, Smith L, Johnson DA, Subramaniam S, Chien S, Shyy JY. PMID: 25890336; PMCID: PMC4357066.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    46. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. Circulation. 2015 Mar 03; 131(9):805-14. Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy JY. PMID: 25550450; PMCID: PMC4351177.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    47. Endothelial dysfunction: the role of sterol regulatory element-binding protein-induced NOD-like receptor family pyrin domain-containing protein 3 inflammasome in atherosclerosis. Curr Opin Lipidol. 2014 Oct; 25(5):339-49. Chen Z, Martin M, Li Z, Shyy JY. PMID: 25188917; PMCID: PMC4339278.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    48. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013 Jun 21; 113(1):40-51. Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, Chiu JJ, Shyy JY, Chien S. PMID: 23603512; PMCID: PMC3772783.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    49. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10355-60. Zhou J, Wang KC, Wu W, Subramaniam S, Shyy JY, Chiu JJ, Li JY, Chien S. PMID: 21636785; PMCID: PMC3121870.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansCells
    50. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3234-9. Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang N, Shyy JY, Li YS, Chien S. PMID: 20133741; PMCID: PMC2840325.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    51. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1902-8. Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy JY, Chien S, García-Cardeña G. PMID: 19696400; PMCID: PMC2766008.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    52. Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H685-92. Wang Y, Chang J, Li YC, Li YS, Shyy JY, Chien S. PMID: 14551058.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    53. Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol. 2002 Nov; 283(5):C1540-7. Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy JY, Chien S. PMID: 12372815.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    54. Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci. 2002 May 15; 115(Pt 10):2199-206. Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy JY, Takada Y, Usami S, Chien S. PMID: 11973360.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    55. Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):76-81. Liu Y, Chen BP, Lu M, Zhu Y, Stemerman MB, Chien S, Shyy JY. PMID: 11788464.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
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    57. Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1042-6. Jalali S, del Pozo MA, Chen K, Miao H, Li Y, Schwartz MA, Shyy JY, Chien S. PMID: 11158591; PMCID: PMC14705.
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    58. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. J Orthop Res. 2000 Nov; 18(6):899-908. Jin G, Sah RL, Li YS, Lotz M, Shyy JY, Chien S. PMID: 11192249.
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    59. Molecular mechanism of endothelial growth arrest by laminar shear stress. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9385-9. Lin K, Hsu PP, Chen BP, Yuan S, Usami S, Shyy JY, Li YS, Chien S. PMID: 10920209; PMCID: PMC16873.
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    60. Mechanical compression modulates proliferation of transplanted chondrocytes. J Orthop Res. 2000 May; 18(3):374-82. Li KW, Falcovitz YH, Nagrampa JP, Chen AC, Lottman LM, Shyy JY, Sah RL. PMID: 10937623.
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    63. Fluid shear stress activation of IkappaB kinase is integrin-dependent. J Biol Chem. 1998 Nov 13; 273(46):30544-9. Bhullar IS, Li YS, Miao H, Zandi E, Kim M, Shyy JY, Chien S. PMID: 9804824.
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    64. Effects of hemodynamic forces on gene expression and signal transduction in endothelial cells. Biol Bull. 1998 Jun; 194(3):390-1; discussion 392-3. Chien S, Shyy JY. PMID: 9664671.
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    65. A strain device imposing dynamic and uniform equi-biaxial strain to cultured cells. Ann Biomed Eng. 1998 Mar-Apr; 26(2):181-9. Sotoudeh M, Jalali S, Usami S, Shyy JY, Chien S. PMID: 9525759.
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    66. Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 1998 Feb; 18(2):227-34. Jalali S, Li YS, Sotoudeh M, Yuan S, Li S, Chien S, Shyy JY. PMID: 9484987.
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    67. Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem. 1997 Nov 28; 272(48):30455-62. Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JY. PMID: 9374537.
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    68. Role of integrins in cellular responses to mechanical stress and adhesion. Curr Opin Cell Biol. 1997 Oct; 9(5):707-13. Shyy JY, Chien S. PMID: 9330875.
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    69. Shear stress induction of the tissue factor gene. J Clin Invest. 1997 Feb 15; 99(4):737-44. Lin MC, Almus-Jacobs F, Chen HH, Parry GC, Mackman N, Shyy JY, Chien S. PMID: 9045878; PMCID: PMC507858.
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    70. The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol. 1996 Nov; 16(11):5947-54. Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S. PMID: 8887624; PMCID: PMC231597.
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    71. Multiple cis-elements mediate shear stress-induced gene expression. J Biomech. 1995 Dec; 28(12):1451-7. Shyy JY, Li YS, Lin MC, Chen W, Yuan S, Usami S, Chien S. PMID: 8666585.
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    72. The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):8069-73. Shyy JY, Lin MC, Han J, Lu Y, Petrime M, Chien S. PMID: 7644539; PMCID: PMC41288.
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