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John Shyy

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Innate Immune Activation and Endothelial Cell Dysfunction in Acute Kawasaki Disease
    NIH R01HL140898Jan 1, 2018 - Nov 30, 2022
    Role: Co-Principal Investigator
    Flow-Induced Endothelial Innate Immunity and Atherosclerosis Susceptibility
    NIH R01HL125643Aug 5, 2016 - Jul 31, 2020
    Role: Principal Investigator
    Systems Biology Analyses for Hemodynamic Regulation of Vascular Homeostasis
    NIH R01HL108735Aug 24, 2012 - Jun 30, 2021
    Role: Principal Investigator
    The miRNA-mediated Translational De-suppression in Hypoxic Endothelium
    NIH R21HL106567Aug 21, 2012 - May 31, 2015
    Role: Principal Investigator
    Nucleolin Regulation of miRome by Shear Stress
    NIH R01HL106579Jan 1, 2011 - Nov 30, 2022
    Role: Principal Investigator
    Shear stress, SIRT1, and Arterial Stiffening
    NIH R01HL105318Sep 20, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Adiponetin and AMPK Biosensor
    NIH R21HL093731Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Shear Stress, AMPK, and Endothelial Functions
    NIH R01HL089940Jan 1, 2009 - Dec 31, 2013
    Role: Principal Investigator
    Flow Regulation of SREBP in Atherosclerosis
    NIH R01HL077448Jul 1, 2004 - Apr 30, 2009
    Role: Principal Investigator
    STRAIN INDUCTION OF VSMC PROLIFERATION AND APOPTOSIS
    NIH R01HL060789Jul 1, 1998 - Jun 30, 2003
    Role: Principal Investigator
    SHEAR STRESS ENHANCEMENT OF SMOOTH MUSCLE CELL MIGRATION
    NIH R01HL056707Jul 1, 1996 - Jun 30, 2005
    Role: Principal Investigator
    MOLECULAR BASIS OF THE ENDOTHELIAL SHEAR STRESS RECEPTOR
    NIH R29HL056707Jul 1, 1996 - Jun 30, 2000
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. FASEB Bioadv. 2021 May; 3(5):334-355. Lopez-Ramirez MA, McCurdy S, Li W, Haynes MK, Hale P, Francisco K, Oukoloff K, Bautista M, Choi CHJ, Sun H, Gongol B, Shyy JY, Ballatore C, Sklar LA, Gingras AR. PMID: 33977234.
      View in: PubMed   Mentions:
    2. Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions. Proc Natl Acad Sci U S A. 2021 Jan 26; 118(4). Maurya MR, Gupta S, Li JY, Ajami NE, Chen ZB, Shyy JY, Chien S, Subramaniam S. PMID: 33468662.
      View in: PubMed   Mentions:    Fields:    
    3. microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production. JCI Insight. 2020 Dec 03; 5(23). Dong J, He M, Li J, Pessentheiner A, Wang C, Zhang J, Sun Y, Wang WT, Zhang Y, Liu J, Wang SC, Huang PH, Gordts PL, Yuan ZY, Tsimikas S, Shyy JY. PMID: 33119548.
      View in: PubMed   Mentions:    Fields:    
    4. Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nat Commun. 2020 11 30; 11(1):6088. Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J. PMID: 33257668.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020956592. Jain PP, Hosokawa S, Xiong M, Babicheva A, Zhao T, Rodriguez M, Rahimi S, Pourhashemi K, Balistrieri F, Lai N, Malhotra A, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Yuan JX. PMID: 33282184.
      View in: PubMed   Mentions:
    6. Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19. Endocr Pract. 2020 Oct; 26(10):1166-1172. Li J, Wei Q, Li WX, McCowen KC, Xiong W, Liu J, Jiang W, Marin T, Thomas RL, He M, Gongol B, Hepokoski M, Yuan JX, Shyy JY, Xiong N, Malhotra A. PMID: 33471718.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Serum miR-92a is Elevated in Children and Adults with Obstructive Sleep Apnea. J Mol Biomark Diagn. 2020; 11(4). Gongol B, Shang F, He M, Zhao Y, Shi W, Cheng M, Shyy JY, Wang L, Malhotra A, Bhattacharjee R. PMID: 33425479.
      View in: PubMed   Mentions:
    8. Shear stress regulation of miR-93 and miR-484 maturation through nucleolin. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):12974-12979. Gongol B, Marin T, Zhang J, Wang SC, Sun W, He M, Chen S, Chen L, Li J, Liu JH, Martin M, Han Y, Kang J, Johnson DA, Lytle C, Li YS, Huang PH, Chien S, Shyy JY. PMID: 31182601.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications. Arterioscler Thromb Vasc Biol. 2019 05; 39(5):902-914. He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, Shyy JY. PMID: 30917677.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    10. Shear Stress Regulation of Endothelium: A Double-edged Sword. J Transl Int Med. 2018 Jun; 6(2):58-61. Bai L, Shyy JY. PMID: 29984197.
      View in: PubMed   Mentions:
    11. Systems biology analysis of longitudinal functional response of endothelial cells to shear stress. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):10990-10995. Ajami NE, Gupta S, Maurya MR, Nguyen P, Li JY, Shyy JY, Chen Z, Chien S, Subramaniam S. PMID: 28973892.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    12. Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. Circulation. 2017 Oct 03; 136(14):1315-1330. Li Z, Martin M, Zhang J, Huang HY, Bai L, Zhang J, Kang J, He M, Li J, Maurya MR, Gupta S, Zhou G, Sangwung P, Xu YJ, Lei T, Huang HD, Jain M, Jain MK, Subramaniam S, Shyy JY. PMID: 28794002.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    13. Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization. Arterioscler Thromb Vasc Biol. 2017 08; 37(8):1470-1481. Bai L, Li Z, Li Q, Guan H, Zhao S, Liu R, Wang R, Zhang J, Jia Y, Fan J, Wang N, Reddy JK, Shyy JY, Liu E. PMID: 28642237.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    14. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiol Genomics. 2017 Jul 01; 49(7):339-345. Huang TS, Wang KC, Quon S, Nguyen P, Chang TY, Chen Z, Li YS, Subramaniam S, Shyy J, Chien S. PMID: 28500253.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    15. miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. Circ Res. 2017 Jan 20; 120(2):354-365. He M, Chen Z, Martin M, Zhang J, Sangwung P, Woo B, Tremoulet AH, Shimizu C, Jain MK, Burns JC, Shyy JY. PMID: 27923814.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    16. Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation. Trends Endocrinol Metab. 2017 02; 28(2):143-152. Miller YI, Shyy JY. PMID: 27931771.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    17. AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function. Arterioscler Thromb Vasc Biol. 2016 12; 36(12):2358-2368. Shentu TP, He M, Sun X, Zhang J, Zhang F, Gongol B, Marin TL, Zhang J, Wen L, Wang Y, Geary GG, Zhu Y, Johnson DA, Shyy JY. PMID: 27758765.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. Activation of integrin a5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):769-74. Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy JY, Zhu Y. PMID: 26733684.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    19. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. Circulation. 2015 Mar 03; 131(9):805-14. Chen Z, Wen L, Martin M, Hsu CY, Fang L, Lin FM, Lin TY, Geary MJ, Geary GG, Zhao Y, Johnson DA, Chen JW, Lin SJ, Chien S, Huang HD, Miller YI, Huang PH, Shyy JY. PMID: 25550450.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    20. Endothelial dysfunction: the role of sterol regulatory element-binding protein-induced NOD-like receptor family pyrin domain-containing protein 3 inflammasome in atherosclerosis. Curr Opin Lipidol. 2014 Oct; 25(5):339-49. Chen Z, Martin M, Li Z, Shyy JY. PMID: 25188917.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    21. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013 Jun 21; 113(1):40-51. Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, Chiu JJ, Shyy JY, Chien S. PMID: 23603512.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    22. MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10355-60. Zhou J, Wang KC, Wu W, Subramaniam S, Shyy JY, Chiu JJ, Li JY, Chien S. PMID: 21636785.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    23. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3234-9. Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang N, Shyy JY, Li YS, Chien S. PMID: 20133741.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    24. Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expression. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1902-8. Young A, Wu W, Sun W, Benjamin Larman H, Larman HB, Wang N, Li YS, Shyy JY, Chien S, García-Cardeña G. PMID: 19696400.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    25. Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway. . 2004 Feb; 286(2):H685-92. Wang Y, Chang J, Li YC, Li YS, Shyy JY, Chien S. PMID: 14551058.
      View in: PubMed   Mentions:
    26. Interplay between integrins and FLK-1 in shear stress-induced signaling. . 2002 Nov; 283(5):C1540-7. Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy JY, Chien S. PMID: 12372815.
      View in: PubMed   Mentions:
    27. Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci. 2002 May 15; 115(Pt 10):2199-206. Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy JY, Takada Y, Usami S, Chien S. PMID: 11973360.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    28. Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):76-81. Liu Y, Chen BP, Lu M, Zhu Y, Stemerman MB, Chien S, Shyy JY. PMID: 11788464.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    29. DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress. Physiol Genomics. 2001 Oct 10; 7(1):55-63. Chen BP, Li YS, Zhao Y, Chen KD, Li S, Lao J, Yuan S, Shyy JY, Chien S. PMID: 11595792.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    30. Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1042-6. Jalali S, del Pozo MA, Chen K, Miao H, Li Y, Schwartz MA, Shyy JY, Chien S. PMID: 11158591.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    31. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. J Orthop Res. 2000 Nov; 18(6):899-908. Jin G, Sah RL, Li YS, Lotz M, Shyy JY, Chien S. PMID: 11192249.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    32. Molecular mechanism of endothelial growth arrest by laminar shear stress. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9385-9. Lin K, Hsu PP, Chen BP, Yuan S, Usami S, Shyy JY, Li YS, Chien S. PMID: 10920209.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    33. Mechanical compression modulates proliferation of transplanted chondrocytes. J Orthop Res. 2000 May; 18(3):374-82. Li KW, Falcovitz YH, Nagrampa JP, Chen AC, Lottman LM, Shyy JY, Sah RL. PMID: 10937623.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. J Biol Chem. 1999 Jun 25; 274(26):18393-400. Chen KD, Li YS, Kim M, Li S, Yuan S, Chien S, Shyy JY. PMID: 10373445.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    35. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. J Clin Invest. 1999 Apr; 103(8):1141-50. Li S, Chen BP, Azuma N, Hu YL, Wu SZ, Sumpio BE, Shyy JY, Chien S. PMID: 10207166.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    36. Fluid shear stress activation of IkappaB kinase is integrin-dependent. J Biol Chem. 1998 Nov 13; 273(46):30544-9. Bhullar IS, Li YS, Miao H, Zandi E, Kim M, Shyy JY, Chien S. PMID: 9804824.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    37. Effects of hemodynamic forces on gene expression and signal transduction in endothelial cells. Biol Bull. 1998 Jun; 194(3):390-1; discussion 392-3. Chien S, Shyy JY. PMID: 9664671.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    38. A strain device imposing dynamic and uniform equi-biaxial strain to cultured cells. Ann Biomed Eng. 1998 Mar-Apr; 26(2):181-9. Sotoudeh M, Jalali S, Usami S, Shyy JY, Chien S. PMID: 9525759.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    39. Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 1998 Feb; 18(2):227-34. Jalali S, Li YS, Sotoudeh M, Yuan S, Li S, Chien S, Shyy JY. PMID: 9484987.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    40. Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem. 1997 Nov 28; 272(48):30455-62. Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JY. PMID: 9374537.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    41. Role of integrins in cellular responses to mechanical stress and adhesion. Curr Opin Cell Biol. 1997 Oct; 9(5):707-13. Shyy JY, Chien S. PMID: 9330875.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    42. Shear stress induction of the tissue factor gene. J Clin Invest. 1997 Feb 15; 99(4):737-44. Lin MC, Almus-Jacobs F, Chen HH, Parry GC, Mackman N, Shyy JY, Chien S. PMID: 9045878.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    43. The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol. 1996 Nov; 16(11):5947-54. Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S. PMID: 8887624.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    44. Multiple cis-elements mediate shear stress-induced gene expression. J Biomech. 1995 Dec; 28(12):1451-7. Shyy JY, Li YS, Lin MC, Chen W, Yuan S, Usami S, Chien S. PMID: 8666585.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    45. The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):8069-73. Shyy JY, Lin MC, Han J, Lu Y, Petrime M, Chien S. PMID: 7644539.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
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