Kenneth Chien

Title(s)Emeritus Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Human Pluripotent Stem Cell and Progenitor Models of Cardiac and Blood Diseases
    NIH U01HL100408Sep 30, 2009 - Jun 30, 2016
    Role: Co-Principal Investigator
    Characterization of Cardiac Progenitors Derived from 22q11-deleted Patients
    NIH RC1HL099618Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Multipotent heart cell progenitor lineages in cardiac development and disease
    NIH R03HL096319Dec 1, 2008 - May 31, 2009
    Role: Principal Investigator
    Cytoskeletal-Associated Proteins and Cardiomyopathy
    NIH R01HL077181Sep 1, 2005 - May 31, 2010
    Role: Principal Investigator
    NIH R03TW001152Sep 30, 1999 - Aug 31, 2003
    Role: Principal Investigator
    NIH R01HL055926Sep 30, 1995 - Jan 31, 2004
    Role: Principal Investigator
    NIH P50HL053773Feb 1, 1995 - Feb 28, 2006
    Role: Principal Investigator
    NIH R01HL051549Jan 1, 1994 - Dec 31, 1999
    Role: Principal Investigator
    Translational Cardiovascular Science and Medicine
    NIH T32HL007770Jul 1, 1993 - Dec 31, 2009
    Role: Co-Principal Investigator
    NIH R01HL045069May 1, 1991 - Apr 30, 1995
    Role: Principal Investigator
    NIH R01HL036139Dec 1, 1986 - Dec 31, 1993
    Role: Principal Investigator
    NIH K08HL001343Jul 1, 1984 - Jun 30, 1989
    Role: Principal Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH P01HL046345Jun 30, 2014
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Endovascular transplantation of mRNA-enhanced mesenchymal stromal cells results in superior therapeutic protein expression in swine heart. Mol Ther Methods Clin Dev. 2024 Jun 13; 32(2):101225. Al-Saadi J, Waldén M, Sandell M, Sohlmér J, Grankvist R, Friberger I, Andersson A, Carlsten M, Chien K, Lundberg J, Witman N, Holmin S. PMID: 38516693; PMCID: PMC10950887.
      View in: PubMed   Mentions:
    2. Author Correction: Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development. Nat Commun. 2024 Jan 04; 15(1):283. Witman N, Zhou C, Häneke T, Xiao Y, Huang X, Rohner E, Sohlmér J, Grote Beverborg N, Lehtinen ML, Chien KR, Sahara M. PMID: 38177121; PMCID: PMC10766948.
      View in: PubMed   Mentions:    Fields:    
    3. Derivation of human primordial germ cell-like cells in an embryonic-like culture. Nat Commun. 2024 Jan 02; 15(1):167. Esfahani SN, Zheng Y, Arabpour A, Irizarry AMR, Kobayashi N, Xue X, Shao Y, Zhao C, Agranonik NL, Sparrow M, Hunt TJ, Faith J, Lara MJ, Wu QY, Silber S, Petropoulos S, Yang R, Chien KR, Clark AT, Fu J. PMID: 38167821; PMCID: PMC10762101.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development. Nat Commun. 2023 09 05; 14(1):5435. Witman N, Zhou C, Häneke T, Xiao Y, Huang X, Rohner E, Sohlmér J, Grote Beverborg N, Lehtinen ML, Chien KR, Sahara M. PMID: 37669989; PMCID: PMC10480216.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Progress and challenges in stem cell biology. Nat Cell Biol. 2023 Feb; 25(2):203-206. Apostolou E, Blau H, Chien K, Lancaster MA, Tata PR, Trompouki E, Watt FM, Zeng YA, Zernicka-Goetz M. PMID: 36788378.
      View in: PubMed   Mentions:    Fields:    
    6. Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting. Mol Ther. 2023 03 01; 31(3):866-874. Anttila V, Saraste A, Knuuti J, Hedman M, Jaakkola P, Laugwitz KL, Krane M, Jeppsson A, Sillanmäki S, Rosenmeier J, Zingmark P, Rudvik A, Garkaviy P, Watson C, Pangalos MN, Chien KR, Fritsche-Danielson R, Collén A, Gan LM. PMID: 36528793; PMCID: PMC10014220.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    7. Unlocking the promise of mRNA therapeutics. Nat Biotechnol. 2022 Nov; 40(11):1586-1600. Rohner E, Yang R, Foo KS, Goedel A, Chien KR. PMID: 36329321.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    8. Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development. Cell Stem Cell. 2022 09 01; 29(9):1402-1419.e8. Zheng Y, Yan RZ, Sun S, Kobayashi M, Xiang L, Yang R, Goedel A, Kang Y, Xue X, Esfahani SN, Liu Y, Resto Irizarry AM, Wu W, Li Y, Ji W, Niu Y, Chien KR, Li T, Shioda T, Fu J. PMID: 36055194; PMCID: PMC9499422.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    9. Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI. Mol Ther. 2023 01 04; 31(1):211-229. Ai X, Yan B, Witman N, Gong Y, Yang L, Tan Y, Chen Y, Liu M, Lu T, Luo R, Wang H, Chien KR, Wang W, Fu W. PMID: 35982619; PMCID: PMC9840120.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    10. Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure. Nat Commun. 2022 05 31; 13(1):3018. De Genst E, Foo KS, Xiao Y, Rohner E, de Vries E, Sohlmér J, Witman N, Hidalgo A, Kolstad TRS, Louch WE, Pehrsson S, Park A, Ikeda Y, Li X, Mayr LM, Wickson K, Jennbacken K, Hansson K, Fritsche-Danielson R, Hunt J, Chien KR. PMID: 35641497; PMCID: PMC9156741.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    11. Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders. Nat Cell Biol. 2022 05; 24(5):645-658. Eroglu E, Yen CYT, Tsoi YL, Witman N, Elewa A, Joven Araus A, Wang H, Szattler T, Umeano CH, Sohlmér J, Goedel A, Simon A, Chien KR. PMID: 35550612; PMCID: PMC9106584.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors. Nat Cell Biol. 2022 05; 24(5):659-671. Poch CM, Foo KS, De Angelis MT, Jennbacken K, Santamaria G, Bähr A, Wang QD, Reiter F, Hornaschewitz N, Zawada D, Bozoglu T, My I, Meier A, Dorn T, Hege S, Lehtinen ML, Tsoi YL, Hovdal D, Hyllner J, Schwarz S, Sudhop S, Jurisch V, Sini M, Fellows MD, Cummings M, Clarke J, Baptista R, Eroglu E, Wolf E, Klymiuk N, Lu K, Tomasi R, Dendorfer A, Gaspari M, Parrotta E, Cuda G, Krane M, Sinnecker D, Hoppmann P, Kupatt C, Fritsche-Danielson R, Moretti A, Chien KR, Laugwitz KL. PMID: 35550611; PMCID: PMC9106586.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    13. Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors. JCI Insight. 2022 01 25; 7(2). Tang CSM, Mononen M, Lam WY, Jin SC, Zhuang X, Garcia-Barcelo MM, Lin Q, Yang Y, Sahara M, Eroglu E, Chien KR, Hong H, Tam PKH, Gruber PJ. PMID: 34905512; PMCID: PMC8855809.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    14. VEGFA mRNA for regenerative treatment of heart failure. Nat Rev Drug Discov. 2022 01; 21(1):79-80. Collén A, Bergenhem N, Carlsson L, Chien KR, Hoge S, Gan LM, Fritsche-Danielson R. PMID: 34873303; PMCID: PMC8646349.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    15. An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation. Mol Med. 2021 09 08; 27(1):102. Rohner E, Witman N, Sohlmer J, De Genst E, Louch WE, Sahara M, Chien KR. PMID: 34496741; PMCID: PMC8425124.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy. Nat Commun. 2021 08 30; 12(1):5180. Grote Beverborg N, Später D, Knöll R, Hidalgo A, Yeh ST, Elbeck Z, Silljé HHW, Eijgenraam TR, Siga H, Zurek M, Palmér M, Pehrsson S, Albery T, Bomer N, Hoes MF, Boogerd CJ, Frisk M, van Rooij E, Damle S, Louch WE, Wang QD, Fritsche-Danielson R, Chien KR, Hansson KM, Mullick AE, de Boer RA, van der Meer P. PMID: 34462437; PMCID: PMC8405807.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    17. Amnion signals are essential for mesoderm formation in primates. Nat Commun. 2021 08 26; 12(1):5126. Yang R, Goedel A, Kang Y, Si C, Chu C, Zheng Y, Chen Z, Gruber PJ, Xiao Y, Zhou C, Witman N, Eroglu E, Leung CY, Chen Y, Fu J, Ji W, Lanner F, Niu Y, Chien KR. PMID: 34446705; PMCID: PMC8390679.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    18. PHF7 directs cardiac reprogramming. Nat Cell Biol. 2021 05; 23(5):440-442. Eroglu E, Schell JP, Chien KR. PMID: 33941893.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    19. Isolation of human ESC-derived cardiac derivatives and embryonic heart cells for population and single-cell RNA-seq analysis. STAR Protoc. 2021 03 19; 2(1):100339. Santoro F, Chien KR, Sahara M. PMID: 33644774; PMCID: PMC7887647.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways. Commun Biol. 2021 01 19; 4(1):82. Geng Y, Duan H, Xu L, Witman N, Yan B, Yu Z, Wang H, Tan Y, Lin L, Li D, Bai S, Fritsche-Danielson R, Yuan J, Chien K, Wei M, Fu W. PMID: 33469143; PMCID: PMC7815925.
      View in: PubMed   Mentions: 24  Translation:AnimalsCells
    21. Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Mol Ther. 2021 Jan 06; 29(1):409. Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR. PMID: 33296664; PMCID: PMC7791073.
      View in: PubMed   Mentions: 2     Fields:    
    22. Corrigendum to "Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration" [Semin. Cell Dev. Biol. Vol.100 (2020) 29-51]. Semin Cell Dev Biol. 2021 Jan; 109:151. Witman N, Zhou C, Beverborg NG, Sahara M, Chien KR. PMID: 33039299.
      View in: PubMed   Mentions:    Fields:    
    23. Model-Based Analysis Reveals a Sustained and Dose-Dependent Acceleration of Wound Healing by VEGF-A mRNA (AZD8601). CPT Pharmacometrics Syst Pharmacol. 2020 07; 9(7):384-394. Almquist J, Rikard SM, Wågberg M, Bruce AC, Gennemark P, Fritsche-Danielson R, Chien KR, Peirce SM, Hansson K, Lundahl A. PMID: 32438492; PMCID: PMC7376292.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    24. Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage. Stem Cells. 2020 10 01; 38(10):1267-1278. Mononen MM, Leung CY, Xu J, Chien KR. PMID: 32497389.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    25. Genome-wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors. Stem Cells. 2020 06; 38(6):741-755. Xu J, Zhou C, Foo KS, Yang R, Xiao Y, Bylund K, Sahara M, Chien KR. PMID: 32129551; PMCID: PMC7891398.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    26. Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration. Semin Cell Dev Biol. 2020 04; 100:29-51. Witman N, Zhou C, Grote Beverborg N, Sahara M, Chien KR. PMID: 31862220.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    27. In search of the next super models. EMBO Mol Med. 2019 12; 11(12):e11502. Goedel A, Grote Beverborg N, Sahara M, Chien KR. PMID: 31736275; PMCID: PMC6895600.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    28. Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. J Control Release. 2019 09 28; 310:103-114. Yu Z, Witman N, Wang W, Li D, Yan B, Deng M, Wang X, Wang H, Zhou G, Liu W, Sahara M, Cao Y, Fritsche-Danielson R, Zhang W, Fu W, Chien KR. PMID: 31425721.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    29. Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes. Nat Commun. 2019 02 20; 10(1):871. Gan LM, Lagerström-Fermér M, Carlsson LG, Arfvidsson C, Egnell AC, Rudvik A, Kjaer M, Collén A, Thompson JD, Joyal J, Chialda L, Koernicke T, Fuhr R, Chien KR, Fritsche-Danielson R. PMID: 30787295; PMCID: PMC6382754.
      View in: PubMed   Mentions: 83     Fields:    Translation:Humans
    30. Regenerating the field of cardiovascular cell therapy. Nat Biotechnol. 2019 03; 37(3):232-237. Chien KR, Frisén J, Fritsche-Danielson R, Melton DA, Murry CE, Weissman IL. PMID: 30778231.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    31. Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract. Dev Cell. 2019 02 25; 48(4):475-490.e7. Sahara M, Santoro F, Sohlmér J, Zhou C, Witman N, Leung CY, Mononen M, Bylund K, Gruber P, Chien KR. PMID: 30713072.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    32. SMAD4 Is Essential for Human Cardiac Mesodermal Precursor Cell Formation. Stem Cells. 2019 02; 37(2):216-225. Xu J, Gruber PJ, Chien KR. PMID: 30376214; PMCID: PMC7379516.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    33. Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing. Sci Rep. 2018 11 30; 8(1):17509. Sun N, Ning B, Hansson KM, Bruce AC, Seaman SA, Zhang C, Rikard M, DeRosa CA, Fraser CL, Wågberg M, Fritsche-Danielson R, Wikström J, Chien KR, Lundahl A, Hölttä M, Carlsson LG, Peirce SM, Hu S. PMID: 30504800; PMCID: PMC6269526.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    34. Superselective endovascular tissue access using trans-vessel wall technique: feasibility study for treatment applications in heart, pancreas and kidney in swine. J Intern Med. 2019 04; 285(4):398-406. Grankvist R, Jensen-Urstad M, Clarke J, Lehtinen M, Little P, Lundberg J, Arnberg F, Jonsson S, Chien KR, Holmin S. PMID: 30289186.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    35. Lnc'ed in to Cardiogenesis. Cell Stem Cell. 2018 06 01; 22(6):787-789. Sahara M, Eroglu E, Chien KR. PMID: 29859167.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    36. Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine. Mol Ther Methods Clin Dev. 2018 Jun 15; 9:330-346. Carlsson L, Clarke JC, Yen C, Gregoire F, Albery T, Billger M, Egnell AC, Gan LM, Jennbacken K, Johansson E, Linhardt G, Martinsson S, Sadiq MW, Witman N, Wang QD, Chen CH, Wang YP, Lin S, Ticho B, Hsieh PCH, Chien KR, Fritsche-Danielson R. PMID: 30038937; PMCID: PMC6054703.
      View in: PubMed   Mentions: 76  
    37. Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Mol Ther. 2018 07 05; 26(7):1644-1659. Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR. PMID: 29606507; PMCID: PMC6035340.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    38. Heart Regeneration 4.0: Matrix Medicine. Dev Cell. 2017 07 10; 42(1):7-8. Eroglu E, Chien KR. PMID: 28697334.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    39. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2017 Jan 03; 135(1):59-72. Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien KR. PMID: 27803039; PMCID: PMC5195872.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    40. Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nat Commun. 2016 07 19; 7:12118. Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien KR. PMID: 27431579; PMCID: PMC4960302.
      View in: PubMed   Mentions:    Fields:    
    41. Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nat Commun. 2016 Mar 08; 7:10774. Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien KR. PMID: 26952167; PMCID: PMC4786749.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    42. Next generation partnerships in translational science and medicine: Partnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances. EMBO Rep. 2015 Oct; 16(10):1246-9. Ljunggren HG, Chien KR. PMID: 26358954; PMCID: PMC4766463.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Programming and reprogramming a human heart cell. EMBO J. 2015 Mar 12; 34(6):710-38. Sahara M, Santoro F, Chien KR. PMID: 25712211; PMCID: PMC4369310.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    44. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Res. 2015 Jan; 25(1):148. Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien KR. PMID: 25553820; PMCID: PMC4650595.
      View in: PubMed   Mentions: 10     Fields:    
    45. Tolerance induction to human stem cell transplants with extension to their differentiated progeny. Nat Commun. 2014 Dec 01; 5:5629. Lui KO, Howie D, Ng SW, Liu S, Chien KR, Waldmann H. PMID: 25434740.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    46. How to make a cardiomyocyte. Development. 2014 Dec; 141(23):4418-31. Später D, Hansson EM, Zangi L, Chien KR. PMID: 25406392.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    47. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Res. 2014 Dec; 24(12):1420-32. Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR. PMID: 25367124; PMCID: PMC4260345.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    48. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. Cell Rep. 2014 Nov 06; 9(3):810-21. Drawnel FM, Boccardo S, Prummer M, Delobel F, Graff A, Weber M, Gérard R, Badi L, Kam-Thong T, Bu L, Jiang X, Hoflack JC, Kiialainen A, Jeworutzki E, Aoyama N, Carlson C, Burcin M, Gromo G, Boehringer M, Stahlberg H, Hall BJ, Magnone MC, Kolaja K, Chien KR, Bailly J, Iacone R. PMID: 25437537.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansCells
    49. Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine. Cold Spring Harb Perspect Med. 2014 Oct 09; 5(1):a014035. Chien KR, Zangi L, Lui KO. PMID: 25301935; PMCID: PMC4292072.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    50. Next-generation models of human cardiogenesis via genome editing. Cold Spring Harb Perspect Med. 2014 Sep 18; 4(12):a013920. Lian X, Xu J, Li J, Chien KR. PMID: 25237142; PMCID: PMC4292085.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    51. Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA. Stem Cell Res. 2014 Nov; 13(3 Pt B):693-704. Lui KO, Zangi L, Chien KR. PMID: 25043723.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    52. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. PMID: 24813252; PMCID: PMC4172922.
      View in: PubMed   Mentions: 417     Fields:    Translation:HumansCells
    53. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Res. 2014 Jul; 24(7):820-41. Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien KR. PMID: 24810299; PMCID: PMC4085760.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    54. The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload. PLoS One. 2014; 9(4):e93638. Bang ML, Gu Y, Dalton ND, Peterson KL, Chien KR, Chen J. PMID: 24736439; PMCID: PMC3988038.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    55. Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes. Stem Cell Reports. 2013; 1(5):387-96. Feinberg AW, Ripplinger CM, van der Meer P, Sheehy SP, Domian I, Chien KR, Parker KK. PMID: 24286027; PMCID: PMC3841251.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    56. Embryonic heart progenitors and cardiogenesis. Cold Spring Harb Perspect Med. 2013 Oct 01; 3(10):a013847. Brade T, Pane LS, Moretti A, Chien KR, Laugwitz KL. PMID: 24086063; PMCID: PMC3784811.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    57. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA. Cell Res. 2013 Oct; 23(10):1172-86. Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR. PMID: 24018375; PMCID: PMC3790234.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    58. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013 Oct; 31(10):898-907. Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR. PMID: 24013197; PMCID: PMC4058317.
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    59. Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine. Cold Spring Harb Perspect Med. 2013 Sep 01; 3(9):a014050. Yi BA, Mummery CL, Chien KR. PMID: 24003244; PMCID: PMC3753721.
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    60. A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells. Nat Cell Biol. 2013 Sep; 15(9):1098-106. Später D, Abramczuk MK, Buac K, Zangi L, Stachel MW, Clarke J, Sahara M, Ludwig A, Chien KR. PMID: 23974038.
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    61. The years of the monkey. Cell Res. 2013 Oct; 23(10):1161-2. Lian X, Chien KR. PMID: 23958583; PMCID: PMC3790233.
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    62. Body, heal thyself. An interview with Kenneth Chien, Professor of Cardiovascular Research at the Department of Cell & Molecular Biology, and the Department of Medicine at Karolinska Institutet in Sweden. Interview by Holger Breithaupt. EMBO Rep. 2013 Sep; 14(9):755-8. Chien K. PMID: 23938329; PMCID: PMC3790057.
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    63. Regenerative biology: heartbroken embryos heal. Nature. 2013 Jun 27; 498(7455):439-40. Chien KR. PMID: 23783518.
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    64. Cardiac regenerative medicine 2.0. Nat Biotechnol. 2013 Mar; 31(3):209-11. Soh BS, Wu H, Chien KR. PMID: 23471068.
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    65. Reprogramming a broken heart. Cell Stem Cell. 2012 Jul 06; 11(1):3-4. Hansson EM, Chien KR. PMID: 22770235.
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    66. In vivo reprogramming for heart disease. Cell Res. 2012 Nov; 22(11):1521-3. Xu H, Yi BA, Chien KR. PMID: 22751090; PMCID: PMC3494388.
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    67. Cardiomyocyte reprogramming and the new age of cellular alchemy. J Mol Cell Cardiol. 2012 Sep; 53(3):311-3. Chien KR, Yi BA, Xu H, Mummery CL. PMID: 22749824.
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    68. Towards regenerative therapy for cardiac disease. Lancet. 2012 Mar 10; 379(9819):933-942. Ptaszek LM, Mansour M, Ruskin JN, Chien KR. PMID: 22405796.
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    69. Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. Cell Res. 2012 Jan; 22(1):142-54. Xu H, Yi BA, Wu H, Bock C, Gu H, Lui KO, Park JH, Shao Y, Riley AK, Domian IJ, Hu E, Willette R, Lepore J, Meissner A, Wang Z, Chien KR. PMID: 22064699; PMCID: PMC3351933.
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    70. A GPS for heart progenitor cell lineages. Mol Ther. 2011 Sep; 19(9):1576-8. Chmielowiec J, Chang YS, Chien KR. PMID: 21886115; PMCID: PMC3182357.
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    71. Bioengineering heart muscle: a paradigm for regenerative medicine. Annu Rev Biomed Eng. 2011 Aug 15; 13:245-67. Vunjak-Novakovic G, Lui KO, Tandon N, Chien KR. PMID: 21568715; PMCID: PMC3405288.
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    72. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res. 2011 Sep 16; 109(7):758-69. Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR. PMID: 21799151; PMCID: PMC3664427.
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    73. Shortcuts to making cardiomyocytes. Nat Cell Biol. 2011 Mar; 13(3):191-3. Xu H, Yi BA, Chien KR. PMID: 21364566.
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    74. Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. Cardiovasc Res. 2011 Jul 15; 91(2):289-99. Terada R, Warren S, Lu JT, Chien KR, Wessels A, Kasahara H. PMID: 21285290; PMCID: PMC3125071.
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    75. Cardiac origin of smooth muscle cells in the inflow tract. J Mol Cell Cardiol. 2011 Feb; 50(2):337-45. Nakano H, Williams E, Hoshijima M, Sasaki M, Minamisawa S, Chien KR, Nakano A. PMID: 20974149; PMCID: PMC3031779.
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    76. Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat Biotechnol. 2010 Jun; 28(6):611-5. Rodin S, Domogatskaya A, Ström S, Hansson EM, Chien KR, Inzunza J, Hovatta O, Tryggvason K. PMID: 20512123.
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    77. Targeted conditional gene knockout in human embryonic stem cells. Cell Res. 2010 Mar; 20(3):379-82. Bu L, Gao X, Jiang X, Chien KR, Wang Z. PMID: 20142843.
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    78. Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest. 2010 Jan; 120(1):20-8. Yi BA, Wernet O, Chien KR. PMID: 20051633; PMCID: PMC2798699.
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    79. Stem cell models of cardiac development and disease. Annu Rev Cell Dev Biol. 2010; 26:667-87. Musunuru K, Domian IJ, Chien KR. PMID: 20604707; PMCID: PMC3955884.
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    80. A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. Circ Res. 2010 Mar 05; 106(4):695-704. Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, Bickeböller H, Maier LS, Schaper W, Schaper J, Kraft T, Tschöpe C, Linke WA, Chien KR. PMID: 20044516.
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    81. Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science. 2009 Oct 16; 326(5951):426-9. Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien KR. PMID: 19833966; PMCID: PMC2895998.
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    82. Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell. 2009 Oct 02; 5(4):364-77. Hansson EM, Lindsay ME, Chien KR. PMID: 19796617.
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    83. Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models. Cell Calcium. 2009 Sep; 46(3):219-25. Andersson KB, Finsen AV, Sjåland C, Winer LH, Sjaastad I, Odegaard A, Louch WE, Wang Y, Chen J, Chien KR, Sejersted OM, Christensen G. PMID: 19692123; PMCID: PMC4313567.
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    84. Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 2009 Jul 02; 460(7251):113-7. Bu L, Jiang X, Martin-Puig S, Caron L, Zhu S, Shao Y, Roberts DJ, Huang PL, Domian IJ, Chien KR. PMID: 19571884.
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    85. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Lab Invest. 2009 Sep; 89(9):983-93. Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien KR, Kasahara H. PMID: 19546853; PMCID: PMC2733927.
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    86. Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol. 2009 Aug; 47(2):180-7. Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. PMID: 19328205.
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    87. Multipotent islet-1 cardiovascular progenitors in development and disease. Cold Spring Harb Symp Quant Biol. 2008; 73:297-306. Nakano A, Nakano H, Chien KR. PMID: 19204066.
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    88. Prox1 maintains muscle structure and growth in the developing heart. Development. 2009 Feb; 136(3):495-505. Risebro CA, Searles RG, Melville AA, Ehler E, Jina N, Shah S, Pallas J, Hubank M, Dillard M, Harvey NL, Schwartz RJ, Chien KR, Oliver G, Riley PR. PMID: 19091769; PMCID: PMC2655234.
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    89. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science. 2008 Dec 05; 322(5907):1494-7. Chien KR, Domian IJ, Parker KK. PMID: 19056974.
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    90. A prediction model for type 2 diabetes risk among Chinese people. Diabetologia. 2009 Mar; 52(3):443-50. Chien K, Cai T, Hsu H, Su T, Chang W, Chen M, Lee Y, Hu FB. PMID: 19057891.
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    91. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circ Res. 2008 Sep 12; 103(6):580-90. Briggs LE, Takeda M, Cuadra AE, Wakimoto H, Marks MH, Walker AJ, Seki T, Oh SP, Lu JT, Sumners C, Raizada MK, Horikoshi N, Weinberg EO, Yasui K, Ikeda Y, Chien KR, Kasahara H. PMID: 18689573; PMCID: PMC2590500.
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    92. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 03; 454(7200):109-13. Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT. PMID: 18568026; PMCID: PMC2574791.
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    93. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H509-21. Adams JW, Wang J, Davis JR, Liaw C, Gaidarov I, Gatlin J, Dalton ND, Gu Y, Ross J, Behan D, Chien K, Connolly D. PMID: 18539757.
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    94. Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. Hum Mol Genet. 2008 Sep 15; 17(18):2753-65. Geier C, Gehmlich K, Ehler E, Hassfeld S, Perrot A, Hayess K, Cardim N, Wenzel K, Erdmann B, Krackhardt F, Posch MG, Osterziel KJ, Bublak A, Nägele H, Scheffold T, Dietz R, Chien KR, Spuler S, Fürst DO, Nürnberg P, Ozcelik C. PMID: 18505755.
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    95. Regenerative medicine and human models of human disease. Nature. 2008 May 15; 453(7193):302-5. Chien KR. PMID: 18480810.
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    96. Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell. 2008 Apr 10; 2(4):320-31. Martin-Puig S, Wang Z, Chien KR. PMID: 18397752.
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    97. Origins and fates of cardiovascular progenitor cells. Cell. 2008 Feb 22; 132(4):537-43. Wu SM, Chien KR, Mummery C. PMID: 18295570; PMCID: PMC2507768.
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    98. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol. 2008 Mar; 26(3):313-5. Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. PMID: 18278034.
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    99. Toward biologically targeted therapy of calcium cycling defects in heart failure. Physiology (Bethesda). 2008 Feb; 23:6-16. Ikeda Y, Hoshijima M, Chien KR. PMID: 18268360.
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    100. Identification of cardiac-specific myosin light chain kinase. Circ Res. 2008 Mar 14; 102(5):571-80. Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H. PMID: 18202317; PMCID: PMC2504503.
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    101. Islet1 cardiovascular progenitors: a single source for heart lineages? Development. 2008 Jan; 135(2):193-205. Laugwitz KL, Moretti A, Caron L, Nakano A, Chien KR. PMID: 18156162.
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    102. Reversing advanced heart failure by targeting Ca2+ cycling. Annu Rev Med. 2008; 59:13-28. Kaye DM, Hoshijima M, Chien KR. PMID: 18186701.
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    103. Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice. Circ J. 2007 Dec; 71(12):1958-64. Yamamoto R, Akazawa H, Ito K, Toko H, Sano M, Yasuda N, Qin Y, Kudo Y, Sugaya T, Chien KR, Komuro I. PMID: 18037754.
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    104. Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 2007 Jul 31; 116(5):515-25. Knöll R, Postel R, Wang J, Krätzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Kube D, Knöll G, Schäfer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nürnberg P, Schultheiss HP, Schaper W, Schaper J, Bos E, Den Hertog J, van Eeden FJ, Peters PJ, Hasenfuss G, Chien KR, Bakkers J. PMID: 17646580.
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    105. Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals. J Am Coll Cardiol. 2007 Jul 17; 50(3):253-60. Kaye DM, Preovolos A, Marshall T, Byrne M, Hoshijima M, Hajjar R, Mariani JA, Pepe S, Chien KR, Power JM. PMID: 17631218.
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    106. Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly. EMBO J. 2007 Jul 25; 26(14):3283-95. Hirai M, Horiguchi M, Ohbayashi T, Kita T, Chien KR, Nakamura T. PMID: 17581631; PMCID: PMC1933399.
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    107. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 2007 Aug 16; 1(2):165-79. Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans SM, Ding S, Chien KR. PMID: 18371348.
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    108. Molecular medicine: microRNAs and the tell-tale heart. Nature. 2007 May 24; 447(7143):389-90. Chien KR. PMID: 17522664.
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    109. Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium. Ann N Y Acad Sci. 2007 Sep; 1112:171-88. Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. PMID: 17495252.
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    110. Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. J Cell Biol. 2007 Mar 26; 176(7):1061-71. Hirai M, Ohbayashi T, Horiguchi M, Okawa K, Hagiwara A, Chien KR, Kita T, Nakamura T. PMID: 17371835; PMCID: PMC2064089.
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    111. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007 Mar 09; 128(5):947-59. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP. PMID: 17350578; PMCID: PMC2092439.
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    112. The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Mol Biol Cell. 2007 May; 18(5):1723-33. Pomiès P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C, Beckerle MC. PMID: 17332502; PMCID: PMC1855033.
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    113. Identification of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression. Genomics. 2007 Mar; 89(3):370-7. Muller O, Pradervand S, Berger S, Centeno G, Milet A, Nicod P, Pedrazzini T, Tronche F, Schütz G, Chien K, Rossier BC, Firsov D. PMID: 17174066.
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    114. Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection. Cardiovasc Res. 2007 Mar 01; 73(4):739-49. Teutsch C, Kondo RP, Dederko DA, Chrast J, Chien KR, Giles WR. PMID: 17289005.
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    115. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006 Dec 15; 127(6):1151-65. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. PMID: 17123592.
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    116. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007 Jan 11; 445(7124):177-82. Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. PMID: 17108969.
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    117. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 2006 Nov 28; 114(22):2364-73. Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU. PMID: 17101849.
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    118. Reversal of calcium cycling defects in advanced heart failure toward molecular therapy. J Am Coll Cardiol. 2006 Nov 07; 48(9 Suppl 1):A15-23. Hoshijima M, Knöll R, Pashmforoush M, Chien KR. PMID: 17084280.
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    119. Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res. 2006 Sep 29; 99(7):749-57. Weissgerber P, Held B, Bloch W, Kaestner L, Chien KR, Fleischmann BK, Lipp P, Flockerzi V, Freichel M. PMID: 16946137.
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    120. Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. J Leukoc Biol. 2006 Oct; 80(4):850-61. Ricote M, Snyder CS, Leung HY, Chen J, Chien KR, Glass CK. PMID: 16888087.
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    121. Lost and found: cardiac stem cell therapy revisited. J Clin Invest. 2006 Jul; 116(7):1838-40. Chien KR. PMID: 16823485; PMCID: PMC1483159.
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    122. Herceptin and the heart--a molecular modifier of cardiac failure. N Engl J Med. 2006 Feb 23; 354(8):789-90. Chien KR. PMID: 16495390.
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    123. Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Dev Biol. 2006 Mar 15; 291(2):208-17. St Amand TR, Lu JT, Zamora M, Gu Y, Stricker J, Hoshijima M, Epstein JA, Ross JJ, Ruiz-Lozano P, Chien KR. PMID: 16430881.
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    124. Beyond small molecule drugs for heart failure: prospects for gene therapy. Novartis Found Symp. 2006; 274:244-56; discussion 256-9, 272-6. Chien KR. PMID: 17019816.
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    125. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest. 2006 Jan; 116(1):217-27. Peng X, Kraus MS, Wei H, Shen TL, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, Guan JL. PMID: 16374517; PMCID: PMC1319217.
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    126. Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform. J Physiol. 2006 Feb 15; 571(Pt 1):131-46. Kondo RP, Dederko DA, Teutsch C, Chrast J, Catalucci D, Chien KR, Giles WR. PMID: 16357014; PMCID: PMC1805641.
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    127. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18455-60. Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien KR, Ruiz-Lozano P. PMID: 16352730; PMCID: PMC1317903.
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    128. Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice. J Biol Chem. 2006 Jan 06; 281(1):213-20. Wang J, Hoshijima M, Lam J, Zhou Z, Jokiel A, Dalton ND, Hultenby K, Ruiz-Lozano P, Ross J, Tryggvason K, Chien KR. PMID: 16204254.
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    129. Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. J Mol Cell Cardiol. 2005 Aug; 39(2):241-50. Lorenzen-Schmidt I, Stuyvers BD, ter Keurs HE, Date MO, Hoshijima M, Chien KR, McCulloch AD, Omens JH. PMID: 15978612; PMCID: PMC4484861.
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    130. Alchemy and the new age of cardiac muscle cell biology. PLoS Biol. 2005 Apr; 3(4):e131. Chien KR. PMID: 15819607; PMCID: PMC1074813.
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    131. Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization. Mol Psychiatry. 2005 Apr; 10(4):393-406. Zhou X, Long JM, Geyer MA, Masliah E, Kelsoe JR, Wynshaw-Boris A, Chien KR. PMID: 15558077.
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    132. Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. Cell. 2005 Feb 25; 120(4):533-44. Chien KR, Karsenty G. PMID: 15734685.
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    133. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10; 433(7026):647-53. Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. PMID: 15703750; PMCID: PMC5578466.
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    134. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun. 2004 Dec 17; 325(3):852-6. Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien KR, Ishikawa Y, Matsuoka R. PMID: 15541368.
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    135. Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. J Biol Chem. 2005 Mar 04; 280(9):8016-21. Kaliman P, Catalucci D, Lam JT, Kondo R, Gutiérrez JC, Reddy S, Palacín M, Zorzano A, Chien KR, Ruiz-Lozano P. PMID: 15598648.
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    136. Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol. 2004 Dec 07; 44(11):2192-201. Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Choi BY, Bae SW, You CW, Han KH, Park JE, Knöll R, Hoshijima M, Chien KR, Kimura A. PMID: 15582318.
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    137. p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol. 2004 Dec; 24(24):10611-20. Nishida K, Yamaguchi O, Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, Miyazaki J, Sudo T, Hongo K, Kusakari Y, Kurihara S, Chien KR, Takeda J, Hori M, Otsu K. PMID: 15572667; PMCID: PMC533965.
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    138. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol. 2004 Nov; 24(21):9414-23. Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, Schmahl W, Chien KR, Wurst W, Bornkamm GW, Brielmeier M. PMID: 15485910; PMCID: PMC522221.
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    139. Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. EMBO J. 2004 Nov 10; 23(22):4517-25. Pradervand S, Yasukawa H, Muller OG, Kjekshus H, Nakamura T, St Amand TR, Yajima T, Matsumura K, Duplain H, Iwatate M, Woodard S, Pedrazzini T, Ross J, Firsov D, Rossier BC, Hoshijima M, Chien KR. PMID: 15510217; PMCID: PMC526469.
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    140. Development. ES cells to the rescue. Science. 2004 Oct 08; 306(5694):239-40. Chien KR, Moretti A, Laugwitz KL. PMID: 15472069.
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    141. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest. 2004 Oct; 114(7):937-43. Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T, Hikoso S, Hirotani S, Asahi M, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Miyazaki J, Chien KR, Matsuzawa A, Sadamitsu C, Ichijo H, Baccarini M, Hori M, Otsu K. PMID: 15467832; PMCID: PMC518660.
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    142. Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning. Cardiovasc Res. 2004 Sep 01; 63(4):611-6. Smith RM, Suleman N, Lacerda L, Opie LH, Akira S, Chien KR, Sack MN. PMID: 15306216.
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    143. Unravelling Ras signals in cardiovascular disease. Nat Cell Biol. 2004 Sep; 6(9):807-8. Chien KR, Hoshijima M. PMID: 15340447.
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    144. Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice. Cardiovasc Res. 2004 Aug 01; 63(2):293-304. Carrier L, Knöll R, Vignier N, Keller DI, Bausero P, Prudhon B, Isnard R, Ambroisine ML, Fiszman M, Ross J, Schwartz K, Chien KR. PMID: 15249187.
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    145. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med. 2004 Jul; 10(7):739-43. Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A. PMID: 15208705.
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    146. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 2004 Apr 30; 117(3):373-86. Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans SM, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien KR. PMID: 15109497.
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    147. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004 May; 131(9):2219-31. Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W. PMID: 15073151; PMCID: PMC2628765.
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    148. Stem cells: lost in translation. Nature. 2004 Apr 08; 428(6983):607-8. Chien KR. PMID: 15034595.
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    149. The new Silk Road. Nature. 2004 Mar 11; 428(6979):208-9. Chien K, Chien L. PMID: 15014508.
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    150. Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. J Clin Invest. 2004 Mar; 113(5):727-36. Iwanaga Y, Hoshijima M, Gu Y, Iwatate M, Dieterle T, Ikeda Y, Date MO, Chrast J, Matsuzaki M, Peterson KL, Chien KR, Ross J. PMID: 14991071; PMCID: PMC351313.
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    151. The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3697-702. Bale TL, Hoshijima M, Gu Y, Dalton N, Anderson KR, Lee KF, Rivier J, Chien KR, Vale WW, Peterson KL. PMID: 14990799; PMCID: PMC373525.
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    152. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem. 2004 Feb 20; 279(8):6905-10. Kimura A, Kinjyo I, Matsumura Y, Mori H, Mashima R, Harada M, Chien KR, Yasukawa H, Yoshimura A. PMID: 14699146.
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    153. Cardiac mechanotransduction and implications for heart disease. J Mol Med (Berl). 2003 Dec; 81(12):750-6. Knöll R, Hoshijima M, Chien K. PMID: 14551702.
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    154. In vivo high-efficiency transcoronary gene delivery and Cre-LoxP gene switching in the adult mouse heart. Gene Ther. 2003 Oct; 10(21):1814-20. Iwatate M, Gu Y, Dieterle T, Iwanaga Y, Peterson KL, Hoshijima M, Chien KR, Ross J. PMID: 12960971.
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    155. Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. Am J Physiol Heart Circ Physiol. 2004 Jan; 286(1):H424-33. Zheng M, Dilly K, Dos Santos Cruz J, Li M, Gu Y, Ursitti JA, Chen J, Ross J, Chien KR, Lederer JW, Wang Y. PMID: 12969887.
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    156. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol. 2003 Jun; 4(6):551-6. Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, Yoshimura A. PMID: 12754507.
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    157. Calcium and heart failure: the cycle game. Nat Med. 2003 May; 9(5):508-9. Chien KR, Ross J, Hoshijima M. PMID: 12724757.
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    158. Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. J Biol Chem. 2003 Mar 14; 278(11):9570-5. Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, Matsuoka R. PMID: 12645548.
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    159. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng. 2003 Mar 05; 81(5):578-87. Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. PMID: 12514807.
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    160. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest. 2003 Feb; 111(4):469-78. Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU. PMID: 12588885; PMCID: PMC151924.
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    161. Genetic modifiers of cardiac arrhythmias. Trends Mol Med. 2003 Feb; 9(2):59-66. Cheng CF, Kuo HC, Chien KR. PMID: 12615039.
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    162. Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J. 2003 Jan 15; 22(2):216-24. Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthoff K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, Pape HC, Biel M, Hofmann F. PMID: 12514127; PMCID: PMC140107.
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    163. Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies. J Clin Invest. 2003 Jan; 111(2):175-8. Chien KR. PMID: 12531871; PMCID: PMC151886.
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    164. Cre-constructing the heart. Nat Genet. 2003 Jan; 33(1):8-9. Ruiz-Lozano P, Chien KR. PMID: 12509773.
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    165. Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and disease. Novartis Found Symp. 2003; 250:260-70; discussion 271-5, 276-9. St Amand TR, Lu JT, Chien KR. PMID: 12956335.
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    166. Embryonic and neonatal cardiac gene transfer in vivo. Methods Mol Biol. 2003; 219:169-78. Christensen G, Gruber PJ, Wang Y, Chien KR. PMID: 12597007.
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    167. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002 Dec 27; 111(7):943-55. Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR. PMID: 12507422.
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    168. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development. 2002 Dec; 129(24):5827-38. Hamblet NS, Lijam N, Ruiz-Lozano P, Wang J, Yang Y, Luo Z, Mei L, Chien KR, Sussman DJ, Wynshaw-Boris A. PMID: 12421720.
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    169. Converging pathways and principles in heart development and disease: CV@CSH. Cell. 2002 Jul 26; 110(2):153-62. Chien KR, Olson EN. PMID: 12150924.
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    170. Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med. 2002 Aug; 8(8):864-71. Hoshijima M, Ikeda Y, Iwanaga Y, Minamisawa S, Date MO, Gu Y, Iwatate M, Li M, Wang L, Wilson JM, Wang Y, Ross J, Chien KR. PMID: 12134142.
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    171. Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development. Dev Dyn. 2002 Jun; 224(2):154-67. Ferrer-Martínez A, Ruiz-Lozano P, Chien KR. PMID: 12112469.
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    172. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 2002 May; 8(5):459-65. Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J, Chien KR, Lee KF. PMID: 11984589.
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    173. Mixed signals in heart failure: cancer rules. J Clin Invest. 2002 Apr; 109(7):849-55. Hoshijima M, Chien KR. PMID: 11927610; PMCID: PMC150934.
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    174. Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer. Circulation. 2002 Jan 29; 105(4):502-8. Ikeda Y, Gu Y, Iwanaga Y, Hoshijima M, Oh SS, Giordano FJ, Chen J, Nigro V, Peterson KL, Chien KR, Ross J. PMID: 11815435.
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    175. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 01 10; 415(6868):171-5. Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J, Honjo T, Chien KR. PMID: 11805835.
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    176. The MLP family of cytoskeletal Z disc proteins and dilated cardiomyopathy: a stress pathway model for heart failure progression. Cold Spring Harb Symp Quant Biol. 2002; 67:399-408. Hoshijima M, Pashmforoush M, Knöll R, Chien KR. PMID: 12858565.
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    177. Something old, something new, something borrowed, something blue: notes on TCM ten years after. Trends Cardiovasc Med. 2002 Jan; 12(1):1-2. Chien KR. PMID: 11796236.
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    178. Muscle LIM protein in heart failure. Exp Clin Cardiol. 2002; 7(2-3):104-5. Knöll R, Hoshijima M, Chien KR. PMID: 19649232; PMCID: PMC2719181.
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    179. A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell. 2001 Dec 14; 107(6):801-13. Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyêñ-Trân VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR, Chien KR. PMID: 11747815.
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    180. [Developmental genes and heart disease]. Rev Esp Cardiol. 2001 Dec; 54(12):1439-45. Ruiz-Lozano P, Nakamura T, Chien KR. PMID: 11754790.
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    181. Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. J Clin Invest. 2001 Nov; 108(10):1459-67. Yasukawa H, Hoshijima M, Gu Y, Nakamura T, Pradervand S, Hanada T, Hanakawa Y, Yoshimura A, Ross J, Chien KR. PMID: 11714737; PMCID: PMC209425.
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    182. Dobutamine stress cine-MRI of cardiac function in the hearts of adult cardiomyocyte-specific VEGF knockout mice. J Magn Reson Imaging. 2001 Oct; 14(4):374-82. Williams SP, Gerber HP, Giordano FJ, Peale FV, Bernstein LJ, Bunting S, Chien KR, Ferrara N, van Bruggen N. PMID: 11599061.
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    183. Effects of deletion of muscle LIM protein on myocyte function. Am J Physiol Heart Circ Physiol. 2001 Jun; 280(6):H2665-73. Su Z, Yao A, Zubair I, Sugishita K, Ritter M, Li F, Hunter JJ, Chien KR, Barry WH. PMID: 11356623.
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    184. Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med. 2001 May; 7(5):591-7. Pashmforoush M, Pomiès P, Peterson KL, Kubalak S, Ross J, Hefti A, Aebi U, Beckerle MC, Chien KR. PMID: 11329061.
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    185. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5780-5. Giordano FJ, Gerber HP, Williams SP, VanBruggen N, Bunting S, Ruiz-Lozano P, Gu Y, Nath AK, Huang Y, Hickey R, Dalton N, Peterson KL, Ross J, Chien KR, Ferrara N. PMID: 11331753; PMCID: PMC33290.
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    186. To Cre or not to Cre: the next generation of mouse models of human cardiac diseases. Circ Res. 2001 Mar 30; 88(6):546-9. Chien KR. PMID: 11282885.
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    187. Nuclear factor kappa B-inducing kinase and Ikappa B kinase-alpha signal skeletal muscle cell differentiation. J Biol Chem. 2001 Jun 08; 276(23):20228-33. Canicio J, Ruiz-Lozano P, Carrasco M, Palacin M, Chien K, Zorzano A, Kaliman P. PMID: 11279241.
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    188. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res. 2001 Feb 16; 88(3):333-9. Gutstein DE, Morley GE, Tamaddon H, Vaidya D, Schneider MD, Chen J, Chien KR, Stuhlmann H, Fishman GI. PMID: 11179202; PMCID: PMC3630465.
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    189. Myocyte survival pathways and cardiomyopathy: implications for trastuzumab cardiotoxicity. Semin Oncol. 2000 Dec; 27(6 Suppl 11):9-14; discussion 92-100. Chien KR. PMID: 11236034.
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    190. Genomic circuits and the integrative biology of cardiac diseases. Nature. 2000 Sep 14; 407(6801):227-32. Chien KR. PMID: 11001065.
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    191. A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. Cell. 2000 Sep 01; 102(5):671-82. Nguyên-Trân VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, Chien KR. PMID: 11007485.
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    192. Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity. 2000 Aug; 13(2):167-77. Hart A, Melet F, Grossfeld P, Chien K, Jones C, Tunnacliffe A, Favier R, Bernstein A. PMID: 10981960.
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    193. Decreased turnovers of glutathione and ascorbic acid in watanabe heritable hyperlipidemic rabbits. J Nutr Sci Vitaminol (Tokyo). 2000 Aug; 46(4):205-9. Suzumura K, Kasahara E, Wang Y, Chien K, Inoue M. PMID: 11185659.
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    194. Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol. 2000 Jun; 20(12):4436-44. Wan YJ, An D, Cai Y, Repa JJ, Hung-Po Chen T, Flores M, Postic C, Magnuson MA, Chen J, Chien KR, French S, Mangelsdorf DJ, Sucov HM. PMID: 10825207; PMCID: PMC85811.
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    195. Co-localisation of CCG repeats and chromosome deletion breakpoints in Jacobsen syndrome: evidence for a common mechanism of chromosome breakage. Hum Mol Genet. 2000 May 01; 9(8):1201-8. Jones C, Müllenbach R, Grossfeld P, Auer R, Favier R, Chien K, James M, Tunnacliffe A, Cotter F. PMID: 10767345.
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    196. Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes. J Mol Cell Cardiol. 2000 May; 32(5):839-51. Doevendans PA, Kubalak SW, An RH, Becker DK, Chien KR, Kass RS. PMID: 10775488.
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    197. Meeting Koch's postulates for calcium signaling in cardiac hypertrophy. J Clin Invest. 2000 May; 105(10):1339-42. Chien KR. PMID: 10811840; PMCID: PMC315474.
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    198. High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates. Circulation. 2000 Jan 18; 101(2):178-84. Christensen G, Minamisawa S, Gruber PJ, Wang Y, Chien KR. PMID: 10637206.
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    199. Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis. J Biol Chem. 1999 Dec 24; 274(52):37362-9. Hertig CM, Kubalak SW, Wang Y, Chien KR. PMID: 10601306.
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    200. Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation. Mol Pharmacol. 1999 Nov; 56(5):886-94. Luo ZD, Wang Y, Werlen G, Camp S, Chien KR, Taylor P. PMID: 10531391.
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    201. Deletion of 150 kb in the minimal DiGeorge/velocardiofacial syndrome critical region in mouse. Hum Mol Genet. 1999 Nov; 8(12):2229-37. Kimber WL, Hsieh P, Hirotsune S, Yuva-Paylor L, Sutherland HF, Chen A, Ruiz-Lozano P, Hoogstraten-Miller SL, Chien KR, Paylor R, Scambler PJ, Wynshaw-Boris A. PMID: 10545603.
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    202. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell. 1999 Oct 29; 99(3):313-22. Minamisawa S, Hoshijima M, Chu G, Ward CA, Frank K, Gu Y, Martone ME, Wang Y, Ross J, Kranias EG, Giles WR, Chien KR. PMID: 10555147.
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    203. Signaling pathways for cardiac hypertrophy and failure. N Engl J Med. 1999 Oct 21; 341(17):1276-83. Hunter JJ, Chien KR. PMID: 10528039.
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    204. Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis. Development. 1999 Oct; 126(19):4223-34. Kuo H, Chen J, Ruiz-Lozano P, Zou Y, Nemer M, Chien KR. PMID: 10477291.
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    205. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell. 1999 Oct; 4(4):585-95. Barak Y, Nelson MC, Ong ES, Jones YZ, Ruiz-Lozano P, Chien KR, Koder A, Evans RM. PMID: 10549290.
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    206. Inflammatory pathways and cardiac repair: the affliction of infarction. Nat Med. 1999 Oct; 5(10):1122-3. Knowlton KU, Chien KR. PMID: 10502807.
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    207. Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11376-81. Tsukui T, Capdevila J, Tamura K, Ruiz-Lozano P, Rodriguez-Esteban C, Yonei-Tamura S, Magallón J, Chandraratna RA, Chien K, Blumberg B, Evans RM, Belmonte JC. PMID: 10500184; PMCID: PMC18041.
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    208. Stress pathways and heart failure. Cell. 1999 Sep 03; 98(5):555-8. Chien KR. PMID: 10490095.
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    209. DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. J Biol Chem. 1999 Aug 06; 274(32):22476-83. Nakamura T, Ruiz-Lozano P, Lindner V, Yabe D, Taniwaki M, Furukawa Y, Kobuke K, Tashiro K, Lu Z, Andon NL, Schaub R, Matsumori A, Sasayama S, Chien KR, Honjo T. PMID: 10428823.
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    210. Complexity in simplicity: monogenic disorders and complex cardiomyopathies. J Clin Invest. 1999 Jun; 103(11):1483-5. Chen J, Chien KR. PMID: 10359556; PMCID: PMC408378.
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    211. Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. J Clin Invest. 1999 Jun; 103(12):1627-34. Sah VP, Minamisawa S, Tam SP, Wu TH, Dorn GW, Ross J, Chien KR, Brown JH. PMID: 10377168; PMCID: PMC408391.
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    212. p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression. Cell Growth Differ. 1999 May; 10(5):295-306. Ruiz-Lozano P, Hixon ML, Wagner MW, Flores AI, Ikawa S, Baldwin AS, Chien KR, Gualberto A. PMID: 10359011.
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    213. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):5043-8. Marszalek JR, Ruiz-Lozano P, Roberts E, Chien KR, Goldstein LS. PMID: 10220415; PMCID: PMC21813.
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    214. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell. 1999 Apr 16; 97(2):189-98. Hirota H, Chen J, Betz UA, Rajewsky K, Gu Y, Ross J, Müller W, Chien KR. PMID: 10219240.
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    215. A post-transcriptional compensatory pathway in heterozygous ventricular myosin light chain 2-deficient mice results in lack of gene dosage effect during normal cardiac growth or hypertrophy. J Biol Chem. 1999 Apr 09; 274(15):10066-70. Minamisawa S, Gu Y, Ross J, Chien KR, Chen J. PMID: 10187786.
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    216. Good fences make good neighbors : cardiovascular science and medicine at the end of the millenium. Circulation. 1999 Jan 5-12; 99(1):6-7. Chien KR. PMID: 9884369.
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    217. Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos. Development. 1998 Nov; 125(22):4427-38. Gruber PJ, Kubalak SW, Chien KR. PMID: 9778502.
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    218. Distinct molecular phenotypes in murine cardiac muscle development, growth, and hypertrophy. J Mol Cell Cardiol. 1998 Nov; 30(11):2269-80. Schoenfeld JR, Vasser M, Jhurani P, Ng P, Hunter JJ, Ross J, Chien KR, Lowe DG. PMID: 9925364.
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    219. Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13024-9. Liu X, Hwang H, Cao L, Buckland M, Cunningham A, Chen J, Chien KR, Graham RM, Zhou M. PMID: 9789034; PMCID: PMC23694.
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    220. Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction. J Card Fail. 1998 Sep; 4(3):213-24. Hongo M, Sentianin EM, Tanaka N, Mao L, McKirnan MD, Clark RG, Won W, Chien KR, Ross J. PMID: 9754592.
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    221. Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10140-5. Adams JW, Sakata Y, Davis MG, Sah VP, Wang Y, Liggett SB, Chien KR, Brown JH, Dorn GW. PMID: 9707614; PMCID: PMC21475.
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    222. A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation. J Biol Chem. 1998 Aug 14; 273(33):21077-83. Cao L, Zhang L, Ruiz-Lozano P, Yang Q, Chien KR, Graham RM, Zhou M. PMID: 9694860.
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    223. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):7000-5. Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J, Lefkowitz RJ, Koch WJ. PMID: 9618528; PMCID: PMC22717.
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    224. Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development. 1998 May; 125(10):1943-9. Chen J, Kubalak SW, Chien KR. PMID: 9550726.
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    225. The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase. J Biol Chem. 1998 Mar 27; 273(13):7725-30. Hoshijima M, Sah VP, Wang Y, Chien KR, Brown JH. PMID: 9516480.
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    226. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem. 1998 Mar 06; 273(10):5423-6. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR. PMID: 9488659.
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    227. Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos. Development. 1998 Feb; 125(3):533-44. Ruiz-Lozano P, Smith SM, Perkins G, Kubalak SW, Boss GR, Sucov HM, Evans RM, Chien KR. PMID: 9425147.
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    228. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem. 1998 Jan 23; 273(4):2161-8. Wang Y, Huang S, Sah VP, Ross J, Brown JH, Han J, Chien KR. PMID: 9442057.
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    229. Selective requirement of myosin light chain 2v in embryonic heart function. J Biol Chem. 1998 Jan 09; 273(2):1252-6. Chen J, Kubalak SW, Minamisawa S, Price RL, Becker KD, Hickey R, Ross J, Chien KR. PMID: 9422794.
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    230. Tangled up in blue: molecular cardiology in the postmolecular era. Circulation. 1997 Dec 16; 96(12):4126-30. Pashmforoush M, Chien KR. PMID: 9416876.
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    231. Left ventricular volumes and function in the embryonic mouse heart. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1368-76. Tanaka N, Mao L, DeLano FA, Sentianin EM, Chien KR, Schmid-Schönbein GW, Ross J. PMID: 9321827.
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    232. Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development. J Mol Med (Berl). 1997 Jul; 75(7):492-501. Wollert KC, Chien KR. PMID: 9253712.
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    233. Physiological assessment of complex cardiac phenotypes in genetically engineered mice. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2513-24. Christensen G, Wang Y, Chien KR. PMID: 9227526.
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    234. Fashioning the vertebrate heart: earliest embryonic decisions. Development. 1997 Jun; 124(11):2099-117. Fishman MC, Chien KR. PMID: 9187138.
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    235. The MEKK-JNK pathway is stimulated by alpha1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy. J Biol Chem. 1997 May 30; 272(22):14057-61. Ramirez MT, Sah VP, Zhao XL, Hunter JJ, Chien KR, Brown JH. PMID: 9162028.
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    236. Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4710-5. Gottshall KR, Hunter JJ, Tanaka N, Dalton N, Becker KD, Ross J, Chien KR. PMID: 9114056; PMCID: PMC20789.
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    237. Point mutations in human beta cardiac myosin heavy chain have differential effects on sarcomeric structure and assembly: an ATP binding site change disrupts both thick and thin filaments, whereas hypertrophic cardiomyopathy mutations display normal assembly. J Cell Biol. 1997 Apr 07; 137(1):131-40. Becker KD, Gottshall KR, Hickey R, Perriard JC, Chien KR. PMID: 9105042; PMCID: PMC2139848.
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    238. Developmental expression of the murine spliceosome-associated protein mSAP49. Dev Dyn. 1997 Apr; 208(4):482-90. Ruiz-Lozano P, Doevendans P, Brown A, Gruber PJ, Chien KR. PMID: 9097020.
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    239. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy. J Biol Chem. 1997 Feb 28; 272(9):5783-91. Sheng Z, Knowlton K, Chen J, Hoshijima M, Brown JH, Chien KR. PMID: 9038192.
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    240. Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel on Heart Failure Research. Circulation. 1997 Feb 18; 95(4):766-70. Cohn JN, Bristow MR, Chien KR, Colucci WS, Frazier OH, Leinwand LA, Lorell BH, Moss AJ, Sonnenblick EH, Walsh RA, Mockrin SC, Reinlib L. PMID: 9054723.
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    241. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell. 1997 Feb 07; 88(3):393-403. Arber S, Hunter JJ, Ross J, Hongo M, Sansig G, Borg J, Perriard JC, Chien KR, Caroni P. PMID: 9039266.
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    242. CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Development. 1997 Feb; 124(4):793-804. Zou Y, Evans S, Chen J, Kuo HC, Harvey RP, Chien KR. PMID: 9043061.
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    243. A novel A/T-rich element mediates ANF gene expression during cardiac myocyte hypertrophy. J Mol Cell Cardiol. 1997 Feb; 29(2):515-25. Harris AN, Ruiz-Lozano P, Chen YF, Sionit P, Yu YT, Lilly B, Olson EN, Chien KR. PMID: 9140811.
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    244. Toward molecular strategies for heart disease--past, present, future. Jpn Circ J. 1997 Feb; 61(2):91-118. Chien KR, Shimizu M, Hoshijima M, Minamisawa S, Grace AA. PMID: 9070966.
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    245. Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. J Biol Chem. 1996 Dec 06; 271(49):31185-90. Sah VP, Hoshijima M, Chien KR, Brown JH. PMID: 8940118.
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    246. A genetic based model of cardiac hypertrophy in MLC-ras mice. J Card Fail. 1996 Dec; 2(4 Suppl):S28-34. Gottshall KR, Becker KD, Hunter JJ, Chien KR. PMID: 8951558.
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    247. Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. J Clin Invest. 1996 Dec 01; 98(11):2648-55. Lembo G, Rockman HA, Hunter JJ, Steinmetz H, Koch WJ, Ma L, Prinz MP, Ross J, Chien KR, Powell-Braxton L. PMID: 8958230; PMCID: PMC507725.
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    248. RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. J Clin Invest. 1996 Sep 15; 98(6):1332-43. Gruber PJ, Kubalak SW, Pexieder T, Sucov HM, Evans RM, Chien KR. PMID: 8823298; PMCID: PMC507559.
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    249. Neurofilament M mRNA is expressed in conduction system myocytes of the developing and adult rabbit heart. J Mol Cell Cardiol. 1996 Sep; 28(9):1833-44. Vitadello M, Vettore S, Lamar E, Chien KR, Gorza L. PMID: 8899542.
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    250. Transthoracic echocardiography in models of cardiac disease in the mouse. Circulation. 1996 Sep 01; 94(5):1109-17. Tanaka N, Dalton N, Mao L, Rockman HA, Peterson KL, Gottshall KR, Hunter JJ, Chien KR, Ross J. PMID: 8790053.
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    251. Cardiovascular effects of insulin-like growth factor-1 and growth hormone in chronic left ventricular failure in the rat. Circulation. 1996 Jun 15; 93(12):2188-96. Duerr RL, McKirnan MD, Gim RD, Clark RG, Chien KR, Ross J. PMID: 8925588.
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    252. Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells. Blood. 1996 Jun 15; 87(12):4937-43. Said W, Chien K, Takeuchi S, Tasaka T, Asou H, Cho SK, de Vos S, Cesarman E, Knowles DM, Koeffler HP. PMID: 8652805.
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    253. Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways. Cytokine Growth Factor Rev. 1996 Jun; 7(1):81-91. Pennica D, Wood WI, Chien KR. PMID: 8864356.
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    254. An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression. Development. 1996 Jun; 122(6):1799-809. Ross RS, Navankasattusas S, Harvey RP, Chien KR. PMID: 8674419.
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    255. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways. J Biol Chem. 1996 Apr 19; 271(16):9535-45. Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, Vernallis AB, Heath JK, Pennica D, Wood WI, Chien KR. PMID: 8621626.
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    256. Expression of cardiac muscle markers in rat myocyte cell lines. Mol Cell Biochem. 1996 Apr 12-26; 157(1-2):87-91. Engelmann GL, Worrell RA, Duff RA, Grutkoski PS, Chien KR, Harvey RP. PMID: 8739232.
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    257. Strategies for studying cardiovascular phenotypes in genetically manipulated mice. Hypertension. 1996 Mar; 27(3 Pt 2):495-501. Becker KD, Gottshall KR, Chien KR. PMID: 8613192.
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    258. Developmental changes in beta-adrenergic modulation of L-type Ca2+ channels in embryonic mouse heart. Circ Res. 1996 Mar; 78(3):371-8. An RH, Davies MP, Doevendans PA, Kubalak SW, Bangalore R, Chien KR, Kass RS. PMID: 8593695.
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    259. Genes and physiology: molecular physiology in genetically engineered animals. J Clin Invest. 1996 Feb 15; 97(4):901-9. Chien KR. PMID: 8613542; PMCID: PMC507134.
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    260. Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. Development. 1996 Feb; 122(2):419-28. Sheng Z, Pennica D, Wood WI, Chien KR. PMID: 8625793.
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    261. Developmental changes in ionic channel activity in the embryonic murine heart. Circ Res. 1996 Jan; 78(1):15-25. Davies MP, An RH, Doevendans P, Kubalak S, Chien KR, Kass RS. PMID: 8603498.
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    262. Molecular medicine in genetically engineered animals: series introduction. J Clin Invest. 1996 Jan 01; 97(1):2. Chien KR. PMID: 8550834; PMCID: PMC507054.
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    263. The molecular genetics of retinoic acid receptors: cardiovascular and limb development. Biochem Soc Symp. 1996; 62:143-56. Sucov HM, Lou J, Gruber PJ, Kubalak SW, Dyson E, Gumeringer CL, Lee RY, Moles SA, Chien KR, Giguere V, Evans RM. PMID: 8971347.
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    264. Molecular cardiology in the postmolecular era Turning toward complexity. Trends Cardiovasc Med. 1996 Jan; 6(1):1-3. Chien KR. PMID: 21232267.
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    265. Congenital long QT syndromes. Toward molecular dissection of arrhythmia substrates. Circulation. 1995 Nov 15; 92(10):2786-9. Grace AA, Chien KR. PMID: 7586240.
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    266. Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase. Mol Biol Cell. 1995 Nov; 6(11):1479-90. Thorburn J, Carlson M, Mansour SJ, Chien KR, Ahn NG, Thorburn A. PMID: 8589450; PMCID: PMC301305.
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    267. Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. J Biol Chem. 1995 Sep 29; 270(39):23173-8. Hunter JJ, Tanaka N, Rockman HA, Ross J, Chien KR. PMID: 7559464.
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    268. Cardiac muscle diseases in genetically engineered mice: evolution of molecular physiology. Am J Physiol. 1995 Sep; 269(3 Pt 2):H755-66. Chien KR. PMID: 7573515.
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    269. Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. J Clin Invest. 1995 Sep; 96(3):1311-8. Knowlton KU, Rockman HA, Itani M, Vovan A, Seidman CE, Chien KR. PMID: 7657806; PMCID: PMC185753.
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    270. Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice. Proc Natl Acad Sci U S A. 1995 Aug 01; 92(16):7386-90. Dyson E, Sucov HM, Kubalak SW, Schmid-Schönbein GW, DeLano FA, Evans RM, Ross J, Chien KR. PMID: 7638202; PMCID: PMC41344.
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    271. Heart and lung disease in engineered mice. Nat Med. 1995 Aug; 1(8):749-51. Lin MC, Rockman HA, Chien KR. PMID: 7585174.
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    272. Retinoid-dependent pathways suppress myocardial cell hypertrophy. Proc Natl Acad Sci U S A. 1995 Aug 01; 92(16):7391-5. Zhou MD, Sucov HM, Evans RM, Chien KR. PMID: 7638203; PMCID: PMC41345.
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    273. Close encounters with ET-1. J Clin Invest. 1995 Jul; 96(1):1-3. Chien KR. PMID: 7615778; PMCID: PMC185164.
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    274. EFIA/YB-1 is a component of cardiac HF-1A binding activity and positively regulates transcription of the myosin light-chain 2v gene. Mol Cell Biol. 1995 Jun; 15(6):2972-82. Zou Y, Chien KR. PMID: 7760795; PMCID: PMC230528.
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    275. Signaling pathways for cardiac growth and hypertrophy. Recent advances and prospects for growth factor therapy. Ann N Y Acad Sci. 1995 Mar 27; 752:115-27. Lembo G, Hunter JJ, Chien KR. PMID: 7755250.
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    276. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci U S A. 1995 Feb 14; 92(4):1142-6. Pennica D, King KL, Shaw KJ, Luis E, Rullamas J, Luoh SM, Darbonne WC, Knutzon DS, Yen R, Chien KR, et al. PMID: 7862649; PMCID: PMC42654.
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    277. Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. J Clin Invest. 1995 Feb; 95(2):619-27. Duerr RL, Huang S, Miraliakbar HR, Clark R, Chien KR, Ross J. PMID: 7860746; PMCID: PMC295527.
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    278. The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements. Mol Cell Biol. 1994 Nov; 14(11):7331-9. Navankasattusas S, Sawadogo M, van Bilsen M, Dang CV, Chien KR. PMID: 7935447; PMCID: PMC359268.
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    279. Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. J Biol Chem. 1994 Jun 17; 269(24):16961-70. Kubalak SW, Miller-Hance WC, O'Brien TX, Dyson E, Chien KR. PMID: 8207020.
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    280. Heterokaryons of cardiac myocytes and fibroblasts reveal the lack of dominance of the cardiac muscle phenotype. Mol Cell Biol. 1994 Jun; 14(6):4269-79. Evans SM, Tai LJ, Tan VP, Newton CB, Chien KR. PMID: 8196663; PMCID: PMC358793.
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    281. Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation. J Biol Chem. 1994 May 06; 269(18):13490-6. LaMorte VJ, Thorburn J, Absher D, Spiegel A, Brown JH, Chien KR, Feramisco JR, Knowlton KU. PMID: 8175782.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    282. RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev. 1994 May 01; 8(9):1007-18. Sucov HM, Dyson E, Gumeringer CL, Price J, Chien KR, Evans RM. PMID: 7926783.
      View in: PubMed   Mentions: 171     Fields:    Translation:AnimalsCells
    283. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science. 1994 Apr 22; 264(5158):582-6. Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR, Johnson TD, Bond RA, Lefkowitz RJ. PMID: 8160017.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansAnimalsCells
    284. Molecular and physiological alterations in murine ventricular dysfunction. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2694-8. Rockman HA, Ono S, Ross RS, Jones LR, Karimi M, Bhargava V, Ross J, Chien KR. PMID: 8146176; PMCID: PMC43436.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    285. Positive regulatory elements (HF-1a and HF-1b) and a novel negative regulatory element (HF-3) mediate ventricular muscle-specific expression of myosin light-chain 2-luciferase fusion genes in transgenic mice. Mol Cell Biol. 1994 Feb; 14(2):1220-9. Lee KJ, Hickey R, Zhu H, Chien KR. PMID: 8289802; PMCID: PMC358478.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    286. Genetic engineering of cardiac muscle cells: in vitro and in vivo. Genet Eng (N Y). 1994; 16:17-31. Fuller SJ, Chien KR. PMID: 7765197.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    287. In vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myosin light chain-2 gene is independent of heart tube formation. J Biol Chem. 1993 Nov 25; 268(33):25244-52. Miller-Hance WC, LaCorbiere M, Fuller SJ, Evans SM, Lyons G, Schmidt C, Robbins J, Chien KR. PMID: 8227090.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    288. Targeting gene expression to specific cardiovascular cell types in transgenic mice. Hypertension. 1993 Oct; 22(4):608-17. Hunter JJ, Zhu H, Lee KJ, Kubalak S, Chien KR. PMID: 8406667.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    289. The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem. 1993 Jul 25; 268(21):15374-80. Knowlton KU, Michel MC, Itani M, Shubeita HE, Ishihara K, Brown JH, Chien KR. PMID: 8393439.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    290. Growth and hypertrophy of the heart: towards an understanding of cardiac specific and inducible gene expression. Cardiovasc Res. 1993 Jul; 27(7):1140-9. van Bilsen M, Chien KR. PMID: 8252572.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    291. A novel, tissue-restricted zinc finger protein (HF-1b) binds to the cardiac regulatory element (HF-1b/MEF-2) in the rat myosin light-chain 2 gene. Mol Cell Biol. 1993 Jul; 13(7):4432-44. Zhu H, Nguyen VT, Brown AB, Pourhosseini A, Garcia AV, van Bilsen M, Chien KR. PMID: 8321243; PMCID: PMC360013.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    292. Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5157-61. O'Brien TX, Lee KJ, Chien KR. PMID: 8506363; PMCID: PMC46674.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    293. Molecular advances in cardiovascular biology. Science. 1993 May 14; 260(5110):916-7. Chien KR. PMID: 8493528.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    294. Expression of SV40 virus large T antigen by recombinant adenoviruses activates proliferation of corneal endothelium in vitro. J Clin Invest. 1993 Apr; 91(4):1713-20. Feldman ST, Gjerset R, Gately D, Chien KR, Feramisco JR. PMID: 8386193; PMCID: PMC288151.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    295. Of mouse and man: molecular switches that control cardiac growth and development. Heart Dis Stroke. 1993 Mar-Apr; 2(2):157-65. Miller-Hance WC, Chien KR. PMID: 8149103.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    296. Comparative immunopathologic study of hyperacute rejection in naive and sensitized rodent cardiac xenograft models. Transplant Proc. 1993 Feb; 25(1 Pt 1):464-5. Wu GD, Cramer DV, Chapman FA, Wang HK, Chien K, Cole J, Makowka L. PMID: 8438380.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    297. HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy. J Biol Chem. 1993 Jan 25; 268(3):2244-9. Thorburn A, Thorburn J, Chen SY, Powers S, Shubeita HE, Feramisco JR, Chien KR. PMID: 8420993.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    298. Transcriptional regulation during cardiac growth and development. Annu Rev Physiol. 1993; 55:77-95. Chien KR, Zhu H, Knowlton KU, Miller-Hance W, van-Bilsen M, O'Brien TX, Evans SM. PMID: 8466192.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    299. Lessons from lincoln. Trends Cardiovasc Med. 1993 Jan-Feb; 3(1):1. Chien KR. PMID: 21244962.
      View in: PubMed   Mentions:    Fields:    
    300. Microinjection of antibodies and expression vectors into living myocardial cells. Development of a novel approach to identify candidate genes that regulate cardiac growth and hypertrophy. Circulation. 1992 Jun; 85(6):2236-46. Shubeita HE, Thorburn J, Chien KR. PMID: 1534288.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    301. A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression. Mol Cell Biol. 1992 Apr; 12(4):1469-79. Navankasattusas S, Zhu H, Garcia AV, Evans SM, Chien KR. PMID: 1532229; PMCID: PMC369588.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    302. Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes. Proc Natl Acad Sci U S A. 1992 Feb 15; 89(4):1305-9. Shubeita HE, Martinson EA, Van Bilsen M, Chien KR, Brown JH. PMID: 1531537; PMCID: PMC48438.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    303. Recent advances in the molecular biology of cardiac growth and hypertrophy: of mouse and man. Cardiologia. 1992 Feb; 37(2):95-103. Chien KR. PMID: 1534711.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    304. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J. 1991 Dec; 5(15):3037-46. Chien KR, Knowlton KU, Zhu H, Chien S. PMID: 1835945.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    305. Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):8277-81. Rockman HA, Ross RS, Harris AN, Knowlton KU, Steinhelper ME, Field LJ, Ross J, Chien KR. PMID: 1832775; PMCID: PMC52490.
      View in: PubMed   Mentions: 315     Fields:    Translation:AnimalsCells
    306. Heart-to-heart. New approaches for gene transfer in the myocardium. Circulation. 1991 Jun; 83(6):2133-6. O'Brien TX, Hunter JJ, Dyson E, Chien KR. PMID: 2040061.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    307. Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. J Biol Chem. 1991 Apr 25; 266(12):7759-68. Knowlton KU, Baracchini E, Ross RS, Harris AN, Henderson SA, Evans SM, Glembotski CC, Chien KR. PMID: 1850419.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    308. A conserved 28-base-pair element (HF-1) in the rat cardiac myosin light-chain-2 gene confers cardiac-specific and alpha-adrenergic-inducible expression in cultured neonatal rat myocardial cells. Mol Cell Biol. 1991 Apr; 11(4):2273-81. Zhu H, Garcia AV, Ross RS, Evans SM, Chien KR. PMID: 1848675; PMCID: PMC359928.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    309. The polymerase chain reaction (PCR) and cardiovascular diagnosis. Trends Cardiovasc Med. 1991 Jan-Feb; 1(1):1-5. Ross RS, Chien KR. PMID: 21239338.
      View in: PubMed   Mentions:    Fields:    
    310. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. J Biol Chem. 1990 Nov 25; 265(33):20555-62. Shubeita HE, McDonough PM, Harris AN, Knowlton KU, Glembotski CC, Brown JH, Chien KR. PMID: 2173712.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    311. Effects of calcium loading and impaired energy production on metabolic and ultrastructural features of cell injury in cultured neonatal rat cardiac myocytes. Lab Invest. 1990 Sep; 63(3):320-31. Buja LM, Fattor RA, Miller JC, Chien KR, Willerson JT. PMID: 2168502.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    312. Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response. J Biol Chem. 1990 Aug 15; 265(23):13809-17. Iwaki K, Sukhatme VP, Shubeita HE, Chien KR. PMID: 1696258.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    313. Reduced arachidonate metabolism in ATP-depleted myocardial cells occurs early in cell injury. Am J Physiol. 1990 Aug; 259(2 Pt 2):H582-91. Revtyak GE, Buja LM, Chien KR, Campbell WB. PMID: 2117403.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    314. Phorbol esters induce immediate-early genes and activate cardiac gene transcription in neonatal rat myocardial cells. J Mol Cell Cardiol. 1990 Aug; 22(8):901-10. Dunnmon PM, Iwaki K, Henderson SA, Sen A, Chien KR. PMID: 2122001.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    315. Of molecules and myocardium. PCR diagnosis of viral myocarditis in cardiac biopsies. Circulation. 1990 Jul; 82(1):294-5. Ross RS, Chien KR. PMID: 2364515.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    316. Deacylated lipopolysaccharide inhibits plasminogen activator inhibitor-1, prostacyclin, and prostaglandin E2 induction by lipopolysaccharide but not by tumor necrosis factor-alpha. J Immunol. 1990 May 01; 144(9):3506-12. Riedo FX, Munford RS, Campbell WB, Reisch JS, Chien KR, Gerard RD. PMID: 2109778.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    317. Structure, organization, and expression of the rat cardiac myosin light chain-2 gene. Identification of a 250-base pair fragment which confers cardiac-specific expression. J Biol Chem. 1989 Oct 25; 264(30):18142-8. Henderson SA, Spencer M, Sen A, Kumar C, Siddiqui MA, Chien KR. PMID: 2808370.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    318. Association between inhibition of arachidonic acid release and prevention of calcium loading during ATP depletion in cultured rat cardiac myocytes. Am J Pathol. 1989 Sep; 135(3):541-56. Jones RL, Miller JC, Hagler HK, Chien KR, Willerson JT, Buja LM. PMID: 2506756; PMCID: PMC1879881.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    319. Cardiovascular molecular biology. Introduction to the series. Circulation. 1989 Aug; 80(2):219-33. Chien KR, Knowlton KU. PMID: 2502325.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    320. Expression of diverse Na+ channel messenger RNAs in rat myocardium. Evidence for a cardiac-specific Na+ channel. J Clin Invest. 1989 Jul; 84(1):331-6. Sills MN, Xu YC, Baracchini E, Goodman RH, Cooperman SS, Mandel G, Chien KR. PMID: 2544627; PMCID: PMC303986.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    321. Terminally differentiated neonatal rat myocardial cells proliferate and maintain specific differentiated functions following expression of SV40 large T antigen. J Biol Chem. 1988 Dec 15; 263(35):19132-6. Sen A, Dunnmon P, Henderson SA, Gerard RD, Chien KR. PMID: 3198615.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    322. Inhibition of the release of arachidonic acid prevents the development of sarcolemmal membrane defects in cultured rat myocardial cells during adenosine triphosphate depletion. J Clin Invest. 1988 Oct; 82(4):1333-8. Sen A, Miller JC, Reynolds R, Willerson JT, Buja LM, Chien KR. PMID: 3139713; PMCID: PMC442688.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    323. Nucleotide sequence of full length cDNAs encoding rat cardiac myosin light chain-2. Nucleic Acids Res. 1988 May 25; 16(10):4722. Henderson SA, Xu YC, Chien KR. PMID: 3380697; PMCID: PMC336661.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    324. Alpha 1-adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells. Effects on myosin light chain-2 gene expression. J Biol Chem. 1988 May 25; 263(15):7352-8. Lee HR, Henderson SA, Reynolds R, Dunnmon P, Yuan D, Chien KR. PMID: 2835372.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    325. Altered calcium homeostasis and membrane integrity in myocardial cell injury. Adv Exp Med Biol. 1988; 232:115-24. Buja LM, Burton KP, Chien KR, Willerson JT. PMID: 3213680.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    326. Membrane phospholipid metabolism during myocardial ischaemia: past, present and future. Basic Res Cardiol. 1987; 82 Suppl 1:121-5. Sen A, Buja LM, Willerson JT, Chien KR. PMID: 3311000.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    327. Alpha 1-adrenergic stimulation of rat myocardial cells increases protein synthesis. Am J Physiol. 1986 Nov; 251(5 Pt 2):H1076-84. Meidell RS, Sen A, Henderson SA, Slahetka MF, Chien KR. PMID: 3022607.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    328. Accumulation of arachidonate in triacylglycerols and unesterified fatty acids during ischemia and reflow in the isolated rat heart. Correlation with the loss of contractile function and the development of calcium overload. Am J Pathol. 1986 Aug; 124(2):238-45. Burton KP, Buja LM, Sen A, Willerson JT, Chien KR. PMID: 3090888; PMCID: PMC1888304.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    329. Heart myosin light chain 2 gene. Nucleotide sequence of full length cDNA and expression in normal and hypertensive rat. J Biol Chem. 1986 Feb 25; 261(6):2866-72. Kumar CC, Cribbs L, Delaney P, Chien KR, Siddiqui MA. PMID: 3005270.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    330. Mechanisms of accumulation of arachidonic acid in cultured myocardial cells during ATP depletion. Am J Physiol. 1985 Dec; 249(6 Pt 2):H1188-94. Gunn MD, Sen A, Chang A, Willerson JT, Buja LM, Chien KR. PMID: 3934986.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    331. Characterization of a potentially reversible increase in beta-adrenergic receptors in isolated, neonatal rat cardiac myocytes with impaired energy metabolism. Circ Res. 1985 Oct; 57(4):640-5. Buja LM, Muntz KH, Rosenbaum T, Haghani Z, Buja DK, Sen A, Chien KR, Willerson JT. PMID: 2994904.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    332. Alterations of ultrastructure and elemental composition in cultured neonatal rat cardiac myocytes after metabolic inhibition with iodoacetic acid. Lab Invest. 1985 Oct; 53(4):397-412. Buja LM, Hagler HK, Parsons D, Chien K, Reynolds RC, Willerson JT. PMID: 2413276.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    333. Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury. J Clin Invest. 1985 Jun; 75(6):1770-80. Chien KR, Sen A, Reynolds R, Chang A, Kim Y, Gunn MD, Buja LM, Willerson JT. PMID: 3924955; PMCID: PMC425531.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    334. Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids. Circ Res. 1984 Mar; 54(3):313-22. Chien KR, Han A, Sen A, Buja LM, Willerson JT. PMID: 6421507.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    335. In vivo esterification of a synthetic 125I-labeled fatty acid into cardiac glycerolipids. Am J Physiol. 1983 Oct; 245(4):H693-7. Chien KR, Han A, White J, Kulkarni P. PMID: 6624940.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    336. Fatty acylcarnitine accumulation and membrane injury in ischemic canine myocardium. Am J Cardiol. 1983 Oct 01; 52(7):893-7. Chien KR, Sen A, Buja LM, Willerson JT. PMID: 6624683.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    337. Induction of a reversible cardiac lipidosis by a dietary long-chain fatty acid (erucic acid). Relationship to lipid accumulation in border zones of myocardial infarcts. Am J Pathol. 1983 Jul; 112(1):68-77. Chien KR, Bellary A, Nicar M, Mukherjee A, Buja LM. PMID: 6859230; PMCID: PMC1916320.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    338. Influence of chlorpromazine on lysosomal alterations during myocardial ischaemia. Cardiovasc Res. 1983 Jul; 17(7):407-14. Chien KR, Crie JS, Decker RS, Wildenthal K. PMID: 6883416.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    339. Membrane damage in ischemia. Adv Exp Med Biol. 1983; 161:421-31. Buja LM, Chien KR, Burton KP, Hagler HK, Mukherjee A, Willerson JT. PMID: 6135307.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    340. Relationship of mitochondrial alterations and 99mTc pyrophosphate uptake during myocardial ischemia. Am J Physiol. 1982 Aug; 243(2):H268-76. Mukherjee A, Buja LM, Kulkarni P, Nicar M, Chien KR, Willerson JT. PMID: 6287855.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    341. Phospholipid alterations in canine ischemic myocardium. Temporal and topographical correlations with Tc-99m-PPi accumulation and an in vitro sarcolemmal Ca2+ permeability defect. Circ Res. 1981 May; 48(5):711-9. Chien KR, Reeves JP, Buja LM, Bonte F, Parkey RW, Willerson JT. PMID: 7214679.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    342. Ischemic myocardial cell injury. Prevention by chlorpromazine of an accelerated phospholipid degradation and associated membrane dysfunction. Am J Pathol. 1979 Dec; 97(3):505-29. Chien KR, Peau RG, Farber JL. PMID: 507189; PMCID: PMC2042431.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    343. Prevention by chlorpromazine of ischemic liver cell death. Am J Pathol. 1977 Sep; 88(3):539-57. Chien KR, Abrams J, Pfau RG, Farber JL. PMID: 888908; PMCID: PMC2032382.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
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