Kenneth Chien

Title(s)Emeritus Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Human Pluripotent Stem Cell and Progenitor Models of Cardiac and Blood Diseases
    NIH U01HL100408Sep 30, 2009 - Jun 30, 2016
    Role: Co-Principal Investigator
    Characterization of Cardiac Progenitors Derived from 22q11-deleted Patients
    NIH RC1HL099618Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Multipotent heart cell progenitor lineages in cardiac development and disease
    NIH R03HL096319Dec 1, 2008 - May 31, 2009
    Role: Principal Investigator
    Cytoskeletal-Associated Proteins and Cardiomyopathy
    NIH R01HL077181Sep 1, 2005 - May 31, 2010
    Role: Principal Investigator
    NEUREGULIN SIGNALING PATHWAY IN CARDIAC DEVELOPMENT
    NIH R03TW001152Sep 30, 1999 - Aug 31, 2003
    Role: Principal Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH P01HL046345Sep 30, 1998 - Jun 30, 2014
    Role: Co-Principal Investigator
    VITAMIN A SIGNALING AND CARDIAC MORPHOGENIC DEFECTS
    NIH R01HL055926Sep 30, 1995 - Jan 31, 2004
    Role: Principal Investigator
    MOLECULAR PHYSIOLOGY OF HEART FAILURE
    NIH P50HL053773Feb 1, 1995 - Feb 28, 2006
    Role: Principal Investigator
    POSITIVE-NEGATIVE REGULATION OF VENTRICULAR DEVELOPMENT
    NIH R01HL051549Jan 1, 1994 - Dec 31, 1999
    Role: Principal Investigator
    Translational Cardiovascular Science and Medicine
    NIH T32HL007770Jul 1, 1993 - Dec 31, 2009
    Role: Co-Principal Investigator
    REGULATION OF VENTRICULAR ANF EXPRESSION
    NIH R01HL045069May 1, 1991 - Apr 30, 1995
    Role: Principal Investigator
    ADRENERGIC REGULATION OF NEONATAL MYOCARDIAL CELL GROWTH
    NIH R01HL036139Dec 1, 1986 - Dec 31, 1993
    Role: Principal Investigator
    PHOSPHOLIPID ALTERATIONS DURING MYOCARDIAL ISCHEMIA
    NIH K08HL001343Jul 1, 1984 - Jun 30, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. PHF7 directs cardiac reprogramming. Nat Cell Biol. 2021 May; 23(5):440-442. Eroglu E, Schell JP, Chien KR. PMID: 33941893.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Isolation of human ESC-derived cardiac derivatives and embryonic heart cells for population and single-cell RNA-seq analysis. STAR Protoc. 2021 Mar 19; 2(1):100339. Santoro F, Chien KR, Sahara M. PMID: 33644774.
      View in: PubMed   Mentions:
    3. BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways. Commun Biol. 2021 01 19; 4(1):82. Geng Y, Duan H, Xu L, Witman N, Yan B, Yu Z, Wang H, Tan Y, Lin L, Li D, Bai S, Fritsche-Danielson R, Yuan J, Chien K, Wei M, Fu W. PMID: 33469143.
      View in: PubMed   Mentions:
    4. Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Mol Ther. 2021 Jan 06; 29(1):409. Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR. PMID: 33296664.
      View in: PubMed   Mentions:    Fields:    
    5. Corrigendum to "Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration" [Semin. Cell Dev. Biol. Vol.100 (2020) 29-51]. Semin Cell Dev Biol. 2021 Jan; 109:151. Witman N, Zhou C, Beverborg NG, Sahara M, Chien KR. PMID: 33039299.
      View in: PubMed   Mentions:    Fields:    
    6. Model-Based Analysis Reveals a Sustained and Dose-Dependent Acceleration of Wound Healing by VEGF-A mRNA (AZD8601). CPT Pharmacometrics Syst Pharmacol. 2020 07; 9(7):384-394. Almquist J, Rikard SM, Wågberg M, Bruce AC, Gennemark P, Fritsche-Danielson R, Chien KR, Peirce SM, Hansson K, Lundahl A. PMID: 32438492.
      View in: PubMed   Mentions: 1     Fields:    
    7. Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage. Stem Cells. 2020 10 01; 38(10):1267-1278. Mononen MM, Leung CY, Xu J, Chien KR. PMID: 32497389.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Genome-wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors. Stem Cells. 2020 06; 38(6):741-755. Xu J, Zhou C, Foo KS, Yang R, Xiao Y, Bylund K, Sahara M, Chien KR. PMID: 32129551.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration. Semin Cell Dev Biol. 2020 04; 100:29-51. Witman N, Zhou C, Grote Beverborg N, Sahara M, Chien KR. PMID: 31862220.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. In search of the next super models. EMBO Mol Med. 2019 12; 11(12):e11502. Goedel A, Grote Beverborg N, Sahara M, Chien KR. PMID: 31736275.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. J Control Release. 2019 09 28; 310:103-114. Yu Z, Witman N, Wang W, Li D, Yan B, Deng M, Wang X, Wang H, Zhou G, Liu W, Sahara M, Cao Y, Fritsche-Danielson R, Zhang W, Fu W, Chien KR. PMID: 31425721.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes. Nat Commun. 2019 02 20; 10(1):871. Gan LM, Lagerström-Fermér M, Carlsson LG, Arfvidsson C, Egnell AC, Rudvik A, Kjaer M, Collén A, Thompson JD, Joyal J, Chialda L, Koernicke T, Fuhr R, Chien KR, Fritsche-Danielson R. PMID: 30787295.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    13. Regenerating the field of cardiovascular cell therapy. Nat Biotechnol. 2019 03; 37(3):232-237. Chien KR, Frisén J, Fritsche-Danielson R, Melton DA, Murry CE, Weissman IL. PMID: 30778231.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    14. Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract. Dev Cell. 2019 02 25; 48(4):475-490.e7. Sahara M, Santoro F, Sohlmér J, Zhou C, Witman N, Leung CY, Mononen M, Bylund K, Gruber P, Chien KR. PMID: 30713072.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. SMAD4 Is Essential for Human Cardiac Mesodermal Precursor Cell Formation. Stem Cells. 2019 02; 37(2):216-225. Xu J, Gruber PJ, Chien KR. PMID: 30376214.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing. Sci Rep. 2018 11 30; 8(1):17509. Sun N, Ning B, Hansson KM, Bruce AC, Seaman SA, Zhang C, Rikard M, DeRosa CA, Fraser CL, Wågberg M, Fritsche-Danielson R, Wikström J, Chien KR, Lundahl A, Hölttä M, Carlsson LG, Peirce SM, Hu S. PMID: 30504800.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    17. Lnc'ed in to Cardiogenesis. Cell Stem Cell. 2018 06 01; 22(6):787-789. Sahara M, Eroglu E, Chien KR. PMID: 29859167.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    18. Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine. Mol Ther Methods Clin Dev. 2018 Jun 15; 9:330-346. Carlsson L, Clarke JC, Yen C, Gregoire F, Albery T, Billger M, Egnell AC, Gan LM, Jennbacken K, Johansson E, Linhardt G, Martinsson S, Sadiq MW, Witman N, Wang QD, Chen CH, Wang YP, Lin S, Ticho B, Hsieh PCH, Chien KR, Fritsche-Danielson R. PMID: 30038937.
      View in: PubMed   Mentions:
    19. Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Mol Ther. 2018 07 05; 26(7):1644-1659. Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR. PMID: 29606507.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    20. Heart Regeneration 4.0: Matrix Medicine. Dev Cell. 2017 07 10; 42(1):7-8. Eroglu E, Chien KR. PMID: 28697334.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    21. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2017 Jan 03; 135(1):59-72. Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien KR. PMID: 27803039.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    22. Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nat Commun. 2016 07 19; 7:12118. Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien KR. PMID: 27431579.
      View in: PubMed   Mentions:    Fields:    
    23. Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nat Commun. 2016 Mar 08; 7:10774. Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien KR. PMID: 26952167.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    24. Next generation partnerships in translational science and medicine: Partnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances. . 2015 Oct; 16(10):1246-9. Ljunggren HG, Chien KR. PMID: 26358954.
      View in: PubMed   Mentions:
    25. Programming and reprogramming a human heart cell. EMBO J. 2015 Mar 12; 34(6):710-38. Sahara M, Santoro F, Chien KR. PMID: 25712211.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    26. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Res. 2015 Jan; 25(1):148. Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien KR. PMID: 25553820.
      View in: PubMed   Mentions: 5     Fields:    
    27. Tolerance induction to human stem cell transplants with extension to their differentiated progeny. Nat Commun. 2014 Dec 01; 5:5629. Lui KO, Howie D, Ng SW, Liu S, Chien KR, Waldmann H. PMID: 25434740.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    28. How to make a cardiomyocyte. Development. 2014 Dec; 141(23):4418-31. Später D, Hansson EM, Zangi L, Chien KR. PMID: 25406392.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    29. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Res. 2014 Dec; 24(12):1420-32. Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR. PMID: 25367124.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    30. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. Cell Rep. 2014 Nov 06; 9(3):810-21. Drawnel FM, Boccardo S, Prummer M, Delobel F, Graff A, Weber M, Gérard R, Badi L, Kam-Thong T, Bu L, Jiang X, Hoflack JC, Kiialainen A, Jeworutzki E, Aoyama N, Carlson C, Burcin M, Gromo G, Boehringer M, Stahlberg H, Hall BJ, Magnone MC, Kolaja K, Chien KR, Bailly J, Iacone R. PMID: 25437537.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    31. Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine. Cold Spring Harb Perspect Med. 2014 Oct 09; 5(1):a014035. Chien KR, Zangi L, Lui KO. PMID: 25301935.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    32. Next-generation models of human cardiogenesis via genome editing. Cold Spring Harb Perspect Med. 2014 Sep 18; 4(12):a013920. Lian X, Xu J, Li J, Chien KR. PMID: 25237142.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    33. Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA. Stem Cell Res. 2014 Nov; 13(3 Pt B):693-704. Lui KO, Zangi L, Chien KR. PMID: 25043723.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    34. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. PMID: 24813252.
      View in: PubMed   Mentions: 303     Fields:    Translation:HumansCells
    35. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Res. 2014 Jul; 24(7):820-41. Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien KR. PMID: 24810299.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    36. The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload. PLoS One. 2014; 9(4):e93638. Bang ML, Gu Y, Dalton ND, Peterson KL, Chien KR, Chen J. PMID: 24736439.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    37. Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes. Stem Cell Reports. 2013; 1(5):387-96. Feinberg AW, Ripplinger CM, van der Meer P, Sheehy SP, Domian I, Chien KR, Parker KK. PMID: 24286027.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    38. Embryonic heart progenitors and cardiogenesis. Cold Spring Harb Perspect Med. 2013 Oct 01; 3(10):a013847. Brade T, Pane LS, Moretti A, Chien KR, Laugwitz KL. PMID: 24086063.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    39. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA. Cell Res. 2013 Oct; 23(10):1172-86. Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR. PMID: 24018375.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    40. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013 Oct; 31(10):898-907. Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR. PMID: 24013197.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    41. Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine. Cold Spring Harb Perspect Med. 2013 Sep 01; 3(9):a014050. Yi BA, Mummery CL, Chien KR. PMID: 24003244.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    42. A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells. Nat Cell Biol. 2013 Sep; 15(9):1098-106. Später D, Abramczuk MK, Buac K, Zangi L, Stachel MW, Clarke J, Sahara M, Ludwig A, Chien KR. PMID: 23974038.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    43. The years of the monkey. Cell Res. 2013 Oct; 23(10):1161-2. Lian X, Chien KR. PMID: 23958583.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    44. Body, heal thyself. An interview with Kenneth Chien, Professor of Cardiovascular Research at the Department of Cell & Molecular Biology, and the Department of Medicine at Karolinska Institutet in Sweden. Interview by Holger Breithaupt. . 2013 Sep; 14(9):755-8. Chien K. PMID: 23938329.
      View in: PubMed   Mentions:
    45. Regenerative biology: heartbroken embryos heal. Nature. 2013 Jun 27; 498(7455):439-40. Chien KR. PMID: 23783518.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    46. Cardiac regenerative medicine 2.0. Nat Biotechnol. 2013 Mar; 31(3):209-11. Soh BS, Wu H, Chien KR. PMID: 23471068.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    47. Reprogramming a broken heart. Cell Stem Cell. 2012 Jul 06; 11(1):3-4. Hansson EM, Chien KR. PMID: 22770235.
      View in: PubMed   Mentions: 6     Fields:    
    48. In vivo reprogramming for heart disease. Cell Res. 2012 Nov; 22(11):1521-3. Xu H, Yi BA, Chien KR. PMID: 22751090.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    49. Cardiomyocyte reprogramming and the new age of cellular alchemy. J Mol Cell Cardiol. 2012 Sep; 53(3):311-3. Chien KR, Yi BA, Xu H, Mummery CL. PMID: 22749824.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    50. Towards regenerative therapy for cardiac disease. Lancet. 2012 Mar 10; 379(9819):933-942. Ptaszek LM, Mansour M, Ruskin JN, Chien KR. PMID: 22405796.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    51. Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. Cell Res. 2012 Jan; 22(1):142-54. Xu H, Yi BA, Wu H, Bock C, Gu H, Lui KO, Park JH, Shao Y, Riley AK, Domian IJ, Hu E, Willette R, Lepore J, Meissner A, Wang Z, Chien KR. PMID: 22064699.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    52. A GPS for heart progenitor cell lineages. Mol Ther. 2011 Sep; 19(9):1576-8. Chmielowiec J, Chang YS, Chien KR. PMID: 21886115.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    53. Bioengineering heart muscle: a paradigm for regenerative medicine. Annu Rev Biomed Eng. 2011 Aug 15; 13:245-67. Vunjak-Novakovic G, Lui KO, Tandon N, Chien KR. PMID: 21568715.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    54. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res. 2011 Sep 16; 109(7):758-69. Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR. PMID: 21799151.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    55. Shortcuts to making cardiomyocytes. Nat Cell Biol. 2011 Mar; 13(3):191-3. Xu H, Yi BA, Chien KR. PMID: 21364566.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    56. Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. Cardiovasc Res. 2011 Jul 15; 91(2):289-99. Terada R, Warren S, Lu JT, Chien KR, Wessels A, Kasahara H. PMID: 21285290.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    57. Cardiac origin of smooth muscle cells in the inflow tract. J Mol Cell Cardiol. 2011 Feb; 50(2):337-45. Nakano H, Williams E, Hoshijima M, Sasaki M, Minamisawa S, Chien KR, Nakano A. PMID: 20974149.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    58. Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat Biotechnol. 2010 Jun; 28(6):611-5. Rodin S, Domogatskaya A, Ström S, Hansson EM, Chien KR, Inzunza J, Hovatta O, Tryggvason K. PMID: 20512123.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansCells
    59. Targeted conditional gene knockout in human embryonic stem cells. Cell Res. 2010 Mar; 20(3):379-82. Bu L, Gao X, Jiang X, Chien KR, Wang Z. PMID: 20142843.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    60. Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest. 2010 Jan; 120(1):20-8. Yi BA, Wernet O, Chien KR. PMID: 20051633.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    61. Stem cell models of cardiac development and disease. Annu Rev Cell Dev Biol. 2010; 26:667-87. Musunuru K, Domian IJ, Chien KR. PMID: 20604707.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    62. A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. Circ Res. 2010 Mar 05; 106(4):695-704. Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, Bickeböller H, Maier LS, Schaper W, Schaper J, Kraft T, Tschöpe C, Linke WA, Chien KR. PMID: 20044516.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    63. Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science. 2009 Oct 16; 326(5951):426-9. Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien KR. PMID: 19833966.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    64. Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell. 2009 Oct 02; 5(4):364-77. Hansson EM, Lindsay ME, Chien KR. PMID: 19796617.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    65. Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models. Cell Calcium. 2009 Sep; 46(3):219-25. Andersson KB, Finsen AV, Sjåland C, Winer LH, Sjaastad I, Odegaard A, Louch WE, Wang Y, Chen J, Chien KR, Sejersted OM, Christensen G. PMID: 19692123.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    66. Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 2009 Jul 02; 460(7251):113-7. Bu L, Jiang X, Martin-Puig S, Caron L, Zhu S, Shao Y, Roberts DJ, Huang PL, Domian IJ, Chien KR. PMID: 19571884.
      View in: PubMed   Mentions: 236     Fields:    Translation:HumansCells
    67. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Lab Invest. 2009 Sep; 89(9):983-93. Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien KR, Kasahara H. PMID: 19546853.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    68. Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol. 2009 Aug; 47(2):180-7. Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. PMID: 19328205.
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    69. Prox1 maintains muscle structure and growth in the developing heart. Development. 2009 Feb; 136(3):495-505. Risebro CA, Searles RG, Melville AA, Ehler E, Jina N, Shah S, Pallas J, Hubank M, Dillard M, Harvey NL, Schwartz RJ, Chien KR, Oliver G, Riley PR. PMID: 19091769.
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    70. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science. 2008 Dec 05; 322(5907):1494-7. Chien KR, Domian IJ, Parker KK. PMID: 19056974.
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    71. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circ Res. 2008 Sep 12; 103(6):580-90. Briggs LE, Takeda M, Cuadra AE, Wakimoto H, Marks MH, Walker AJ, Seki T, Oh SP, Lu JT, Sumners C, Raizada MK, Horikoshi N, Weinberg EO, Yasui K, Ikeda Y, Chien KR, Kasahara H. PMID: 18689573.
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    72. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 03; 454(7200):109-13. Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT. PMID: 18568026.
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    73. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. . 2008 Aug; 295(2):H509-21. Adams JW, Wang J, Davis JR, Liaw C, Gaidarov I, Gatlin J, Dalton ND, Gu Y, Ross J, Behan D, Chien K, Connolly D. PMID: 18539757.
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    74. Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. Hum Mol Genet. 2008 Sep 15; 17(18):2753-65. Geier C, Gehmlich K, Ehler E, Hassfeld S, Perrot A, Hayess K, Cardim N, Wenzel K, Erdmann B, Krackhardt F, Posch MG, Osterziel KJ, Bublak A, Nägele H, Scheffold T, Dietz R, Chien KR, Spuler S, Fürst DO, Nürnberg P, Ozcelik C. PMID: 18505755.
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    75. Regenerative medicine and human models of human disease. Nature. 2008 May 15; 453(7193):302-5. Chien KR. PMID: 18480810.
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    76. Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell. 2008 Apr 10; 2(4):320-31. Martin-Puig S, Wang Z, Chien KR. PMID: 18397752.
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    77. Origins and fates of cardiovascular progenitor cells. Cell. 2008 Feb 22; 132(4):537-43. Wu SM, Chien KR, Mummery C. PMID: 18295570.
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    78. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol. 2008 Mar; 26(3):313-5. Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. PMID: 18278034.
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    79. Toward biologically targeted therapy of calcium cycling defects in heart failure. Physiology (Bethesda). 2008 Feb; 23:6-16. Ikeda Y, Hoshijima M, Chien KR. PMID: 18268360.
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    80. Identification of cardiac-specific myosin light chain kinase. Circ Res. 2008 Mar 14; 102(5):571-80. Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H. PMID: 18202317.
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    81. Islet1 cardiovascular progenitors: a single source for heart lineages? Development. 2008 Jan; 135(2):193-205. Laugwitz KL, Moretti A, Caron L, Nakano A, Chien KR. PMID: 18156162.
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    82. Reversing advanced heart failure by targeting Ca2+ cycling. Annu Rev Med. 2008; 59:13-28. Kaye DM, Hoshijima M, Chien KR. PMID: 18186701.
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    83. Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice. Circ J. 2007 Dec; 71(12):1958-64. Yamamoto R, Akazawa H, Ito K, Toko H, Sano M, Yasuda N, Qin Y, Kudo Y, Sugaya T, Chien KR, Komuro I. PMID: 18037754.
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    84. Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 2007 Jul 31; 116(5):515-25. Knöll R, Postel R, Wang J, Krätzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Kube D, Knöll G, Schäfer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nürnberg P, Schultheiss HP, Schaper W, Schaper J, Bos E, Den Hertog J, van Eeden FJ, Peters PJ, Hasenfuss G, Chien KR, Bakkers J. PMID: 17646580.
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    85. Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals. J Am Coll Cardiol. 2007 Jul 17; 50(3):253-60. Kaye DM, Preovolos A, Marshall T, Byrne M, Hoshijima M, Hajjar R, Mariani JA, Pepe S, Chien KR, Power JM. PMID: 17631218.
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    86. Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly. EMBO J. 2007 Jul 25; 26(14):3283-95. Hirai M, Horiguchi M, Ohbayashi T, Kita T, Chien KR, Nakamura T. PMID: 17581631.
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    87. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 2007 Aug 16; 1(2):165-79. Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans SM, Ding S, Chien KR. PMID: 18371348.
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    88. Molecular medicine: microRNAs and the tell-tale heart. Nature. 2007 May 24; 447(7143):389-90. Chien KR. PMID: 17522664.
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    89. Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium. Ann N Y Acad Sci. 2007 Sep; 1112:171-88. Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. PMID: 17495252.
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    90. Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. J Cell Biol. 2007 Mar 26; 176(7):1061-71. Hirai M, Ohbayashi T, Horiguchi M, Okawa K, Hagiwara A, Chien KR, Kita T, Nakamura T. PMID: 17371835.
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    91. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007 Mar 09; 128(5):947-59. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP. PMID: 17350578.
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    92. The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Mol Biol Cell. 2007 May; 18(5):1723-33. Pomiès P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C, Beckerle MC. PMID: 17332502.
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    93. Identification of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression. Genomics. 2007 Mar; 89(3):370-7. Muller O, Pradervand S, Berger S, Centeno G, Milet A, Nicod P, Pedrazzini T, Tronche F, Schütz G, Chien K, Rossier BC, Firsov D. PMID: 17174066.
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    94. Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection. Cardiovasc Res. 2007 Mar 01; 73(4):739-49. Teutsch C, Kondo RP, Dederko DA, Chrast J, Chien KR, Giles WR. PMID: 17289005.
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    95. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006 Dec 15; 127(6):1151-65. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. PMID: 17123592.
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    96. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007 Jan 11; 445(7124):177-82. Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. PMID: 17108969.
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    97. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 2006 Nov 28; 114(22):2364-73. Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU. PMID: 17101849.
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    98. Reversal of calcium cycling defects in advanced heart failure toward molecular therapy. J Am Coll Cardiol. 2006 Nov 07; 48(9 Suppl 1):A15-23. Hoshijima M, Knöll R, Pashmforoush M, Chien KR. PMID: 17084280.
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    99. Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res. 2006 Sep 29; 99(7):749-57. Weissgerber P, Held B, Bloch W, Kaestner L, Chien KR, Fleischmann BK, Lipp P, Flockerzi V, Freichel M. PMID: 16946137.
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    100. Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. J Leukoc Biol. 2006 Oct; 80(4):850-61. Ricote M, Snyder CS, Leung HY, Chen J, Chien KR, Glass CK. PMID: 16888087.
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    101. Lost and found: cardiac stem cell therapy revisited. J Clin Invest. 2006 Jul; 116(7):1838-40. Chien KR. PMID: 16823485.
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    102. Herceptin and the heart--a molecular modifier of cardiac failure. N Engl J Med. 2006 Feb 23; 354(8):789-90. Chien KR. PMID: 16495390.
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    103. Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Dev Biol. 2006 Mar 15; 291(2):208-17. St Amand TR, Lu JT, Zamora M, Gu Y, Stricker J, Hoshijima M, Epstein JA, Ross JJ, Ruiz-Lozano P, Chien KR. PMID: 16430881.
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    104. Beyond small molecule drugs for heart failure: prospects for gene therapy. Novartis Found Symp. 2006; 274:244-56; discussion 256-9, 272-6. Chien KR. PMID: 17019816.
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    105. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest. 2006 Jan; 116(1):217-27. Peng X, Kraus MS, Wei H, Shen TL, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, Guan JL. PMID: 16374517.
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    106. Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform. J Physiol. 2006 Feb 15; 571(Pt 1):131-46. Kondo RP, Dederko DA, Teutsch C, Chrast J, Catalucci D, Chien KR, Giles WR. PMID: 16357014.
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    107. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18455-60. Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien KR, Ruiz-Lozano P. PMID: 16352730.
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    108. Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice. J Biol Chem. 2006 Jan 06; 281(1):213-20. Wang J, Hoshijima M, Lam J, Zhou Z, Jokiel A, Dalton ND, Hultenby K, Ruiz-Lozano P, Ross J, Tryggvason K, Chien KR. PMID: 16204254.
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    109. Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. J Mol Cell Cardiol. 2005 Aug; 39(2):241-50. Lorenzen-Schmidt I, Stuyvers BD, ter Keurs HE, Date MO, Hoshijima M, Chien KR, McCulloch AD, Omens JH. PMID: 15978612.
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    110. Alchemy and the new age of cardiac muscle cell biology. PLoS Biol. 2005 Apr; 3(4):e131. Chien KR. PMID: 15819607.
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    111. Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. Cell. 2005 Feb 25; 120(4):533-44. Chien KR, Karsenty G. PMID: 15734685.
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    112. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10; 433(7026):647-53. Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. PMID: 15703750.
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    113. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun. 2004 Dec 17; 325(3):852-6. Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien KR, Ishikawa Y, Matsuoka R. PMID: 15541368.
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    114. Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. J Biol Chem. 2005 Mar 04; 280(9):8016-21. Kaliman P, Catalucci D, Lam JT, Kondo R, Gutiérrez JC, Reddy S, Palacín M, Zorzano A, Chien KR, Ruiz-Lozano P. PMID: 15598648.
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    115. Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol. 2004 Dec 07; 44(11):2192-201. Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Choi BY, Bae SW, You CW, Han KH, Park JE, Knöll R, Hoshijima M, Chien KR, Kimura A. PMID: 15582318.
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    116. p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol. 2004 Dec; 24(24):10611-20. Nishida K, Yamaguchi O, Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, Miyazaki J, Sudo T, Hongo K, Kusakari Y, Kurihara S, Chien KR, Takeda J, Hori M, Otsu K. PMID: 15572667.
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    117. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol. 2004 Nov; 24(21):9414-23. Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, Schmahl W, Chien KR, Wurst W, Bornkamm GW, Brielmeier M. PMID: 15485910.
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    118. Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. EMBO J. 2004 Nov 10; 23(22):4517-25. Pradervand S, Yasukawa H, Muller OG, Kjekshus H, Nakamura T, St Amand TR, Yajima T, Matsumura K, Duplain H, Iwatate M, Woodard S, Pedrazzini T, Ross J, Firsov D, Rossier BC, Hoshijima M, Chien KR. PMID: 15510217.
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    119. Development. ES cells to the rescue. Science. 2004 Oct 08; 306(5694):239-40. Chien KR, Moretti A, Laugwitz KL. PMID: 15472069.
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    120. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest. 2004 Oct; 114(7):937-43. Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T, Hikoso S, Hirotani S, Asahi M, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Miyazaki J, Chien KR, Matsuzawa A, Sadamitsu C, Ichijo H, Baccarini M, Hori M, Otsu K. PMID: 15467832.
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    121. Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning. Cardiovasc Res. 2004 Sep 01; 63(4):611-6. Smith RM, Suleman N, Lacerda L, Opie LH, Akira S, Chien KR, Sack MN. PMID: 15306216.
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    122. Unravelling Ras signals in cardiovascular disease. Nat Cell Biol. 2004 Sep; 6(9):807-8. Chien KR, Hoshijima M. PMID: 15340447.
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    123. Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice. Cardiovasc Res. 2004 Aug 01; 63(2):293-304. Carrier L, Knöll R, Vignier N, Keller DI, Bausero P, Prudhon B, Isnard R, Ambroisine ML, Fiszman M, Ross J, Schwartz K, Chien KR. PMID: 15249187.
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    124. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med. 2004 Jul; 10(7):739-43. Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A. PMID: 15208705.
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    125. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 2004 Apr 30; 117(3):373-86. Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans SM, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien KR. PMID: 15109497.
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    126. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004 May; 131(9):2219-31. Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W. PMID: 15073151.
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    127. Stem cells: lost in translation. Nature. 2004 Apr 08; 428(6983):607-8. Chien KR. PMID: 15034595.
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    128. The new Silk Road. Nature. 2004 Mar 11; 428(6979):208-9. Chien K, Chien L. PMID: 15014508.
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    129. Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. J Clin Invest. 2004 Mar; 113(5):727-36. Iwanaga Y, Hoshijima M, Gu Y, Iwatate M, Dieterle T, Ikeda Y, Date MO, Chrast J, Matsuzaki M, Peterson KL, Chien KR, Ross J. PMID: 14991071.
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    130. The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3697-702. Bale TL, Hoshijima M, Gu Y, Dalton N, Anderson KR, Lee KF, Rivier J, Chien KR, Vale WW, Peterson KL. PMID: 14990799.
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    131. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem. 2004 Feb 20; 279(8):6905-10. Kimura A, Kinjyo I, Matsumura Y, Mori H, Mashima R, Harada M, Chien KR, Yasukawa H, Yoshimura A. PMID: 14699146.
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    132. Cardiac mechanotransduction and implications for heart disease. J Mol Med (Berl). 2003 Dec; 81(12):750-6. Knöll R, Hoshijima M, Chien K. PMID: 14551702.
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    133. Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. . 2004 Jan; 286(1):H424-33. Zheng M, Dilly K, Dos Santos Cruz J, Li M, Gu Y, Ursitti JA, Chen J, Ross J, Chien KR, Lederer JW, Wang Y. PMID: 12969887.
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    135. Calcium and heart failure: the cycle game. Nat Med. 2003 May; 9(5):508-9. Chien KR, Ross J, Hoshijima M. PMID: 12724757.
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    136. Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. J Biol Chem. 2003 Mar 14; 278(11):9570-5. Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, Matsuoka R. PMID: 12645548.
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    137. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng. 2003 Mar 05; 81(5):578-87. Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. PMID: 12514807.
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    138. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest. 2003 Feb; 111(4):469-78. Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU. PMID: 12588885.
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    139. Genetic modifiers of cardiac arrhythmias. Trends Mol Med. 2003 Feb; 9(2):59-66. Cheng CF, Kuo HC, Chien KR. PMID: 12615039.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    140. Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J. 2003 Jan 15; 22(2):216-24. Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthoff K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, Pape HC, Biel M, Hofmann F. PMID: 12514127.
      View in: PubMed   Mentions: 185     Fields:    Translation:AnimalsCells
    141. Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and disease. Novartis Found Symp. 2003; 250:260-70; discussion 271-5, 276-9. St Amand TR, Lu JT, Chien KR. PMID: 12956335.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    142. Embryonic and neonatal cardiac gene transfer in vivo. Methods Mol Biol. 2003; 219:169-78. Christensen G, Gruber PJ, Wang Y, Chien KR. PMID: 12597007.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    143. Cre-constructing the heart. Nat Genet. 2003 Jan; 33(1):8-9. Ruiz-Lozano P, Chien KR. PMID: 12509773.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    144. Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies. J Clin Invest. 2003 Jan; 111(2):175-8. Chien KR. PMID: 12531871.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    145. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002 Dec 27; 111(7):943-55. Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR. PMID: 12507422.
      View in: PubMed   Mentions: 258     Fields:    Translation:HumansAnimalsCells
    146. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development. 2002 Dec; 129(24):5827-38. Hamblet NS, Lijam N, Ruiz-Lozano P, Wang J, Yang Y, Luo Z, Mei L, Chien KR, Sussman DJ, Wynshaw-Boris A. PMID: 12421720.
      View in: PubMed   Mentions: 163     Fields:    Translation:Animals
    147. Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mech Dev. 2002 Sep; 117(1-2):115-22. Jiang X, Choudhary B, Merki E, Chien KR, Maxson RE, Sucov HM. PMID: 12204252.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    148. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11375-80. Zhao YY, Liu Y, Stan RV, Fan L, Gu Y, Dalton N, Chu PH, Peterson K, Ross J, Chien KR. PMID: 12177436.
      View in: PubMed   Mentions: 189     Fields:    Translation:Animals
    149. Converging pathways and principles in heart development and disease: CV@CSH. Cell. 2002 Jul 26; 110(2):153-62. Chien KR, Olson EN. PMID: 12150924.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    150. Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med. 2002 Aug; 8(8):864-71. Hoshijima M, Ikeda Y, Iwanaga Y, Minamisawa S, Date MO, Gu Y, Iwatate M, Li M, Wang L, Wilson JM, Wang Y, Ross J, Chien KR. PMID: 12134142.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    151. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8880-5. Ozcelik C, Erdmann B, Pilz B, Wettschureck N, Britsch S, Hübner N, Chien KR, Birchmeier C, Garratt AN. PMID: 12072561.
      View in: PubMed   Mentions: 123     Fields:    Translation:Animals
    152. Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development. Dev Dyn. 2002 Jun; 224(2):154-67. Ferrer-Martínez A, Ruiz-Lozano P, Chien KR. PMID: 12112469.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    153. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 2002 May; 8(5):459-65. Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J, Chien KR, Lee KF. PMID: 11984589.
      View in: PubMed   Mentions: 243     Fields:    Translation:HumansAnimalsCells
    154. Mixed signals in heart failure: cancer rules. J Clin Invest. 2002 Apr; 109(7):849-55. Hoshijima M, Chien KR. PMID: 11927610.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    155. Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer. Circulation. 2002 Jan 29; 105(4):502-8. Ikeda Y, Gu Y, Iwanaga Y, Hoshijima M, Oh SS, Giordano FJ, Chen J, Nigro V, Peterson KL, Chien KR, Ross J. PMID: 11815435.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    156. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 01 10; 415(6868):171-5. Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J, Honjo T, Chien KR. PMID: 11805835.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimalsCells
    157. Something old, something new, something borrowed, something blue: notes on TCM ten years after. Trends Cardiovasc Med. 2002 Jan; 12(1):1-2. Chien KR. PMID: 11796236.
      View in: PubMed   Mentions:    Fields:    
    158. Muscle LIM protein in heart failure. Exp Clin Cardiol. 2002; 7(2-3):104-5. Knöll R, Hoshijima M, Chien KR. PMID: 19649232.
      View in: PubMed   Mentions:
    159. Meeting Koch's postulates for calcium signaling in cardiac hypertrophy. J Clin Invest. 2000 May; 105(10):1339-42. Chien KR. PMID: 10811840.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
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