Loading...

Kenneth Chien

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0912
La Jolla CA 92093
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Human Pluripotent Stem Cell and Progenitor Models of Cardiac and Blood Diseases
    NIH/NHLBI U01HL100408Sep 30, 2009 - Jun 30, 2016
    Role: Co-Principal Investigator
    Characterization of Cardiac Progenitors Derived from 22q11-deleted Patients
    NIH/NHLBI RC1HL099618Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Multipotent heart cell progenitor lineages in cardiac development and disease
    NIH/NHLBI R03HL096319Dec 1, 2008 - May 31, 2009
    Role: Principal Investigator
    Cytoskeletal-Associated Proteins and Cardiomyopathy
    NIH/NHLBI R01HL077181Sep 1, 2005 - May 31, 2010
    Role: Principal Investigator
    NEUREGULIN SIGNALING PATHWAY IN CARDIAC DEVELOPMENT
    NIH/FIC R03TW001152Sep 30, 1999 - Aug 31, 2003
    Role: Principal Investigator
    VITAMIN A SIGNALING AND CARDIAC MORPHOGENIC DEFECTS
    NIH/NHLBI R01HL055926Sep 30, 1995 - Jan 31, 2004
    Role: Principal Investigator
    MOLECULAR PHYSIOLOGY OF HEART FAILURE
    NIH/NHLBI P50HL053773Feb 1, 1995 - Feb 28, 2006
    Role: Principal Investigator
    POSITIVE-NEGATIVE REGULATION OF VENTRICULAR DEVELOPMENT
    NIH/NHLBI R01HL051549Jan 1, 1994 - Dec 31, 1999
    Role: Principal Investigator
    Translational Cardiovascular Science and Medicine
    NIH/NHLBI T32HL007770Jul 1, 1993 - Dec 31, 2009
    Role: Co-Principal Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH/NHLBI P01HL046345Feb 1, 1992 - Jun 30, 2014
    Role: Co-Principal Investigator
    REGULATION OF VENTRICULAR ANF EXPRESSION
    NIH/NHLBI R01HL045069May 1, 1991 - Apr 30, 1995
    Role: Principal Investigator
    ADRENERGIC REGULATION OF NEONATAL MYOCARDIAL CELL GROWTH
    NIH/NHLBI R01HL036139Dec 1, 1986 - Dec 31, 1993
    Role: Principal Investigator
    PHOSPHOLIPID ALTERATIONS DURING MYOCARDIAL ISCHEMIA
    NIH/NHLBI K08HL001343Jul 1, 1984 - Jun 30, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sahara M, Eroglu E, Chien K. Lnc'ed in to Cardiogenesis. Cell Stem Cell. 2018 Jun 01; 22(6):787-789. PMID: 29859167.
      View in: PubMed
    2. Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien K. Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Mol Ther. 2018 Feb 17. PMID: 29606507.
      View in: PubMed
    3. Eroglu E, Chien K. Heart Regeneration 4.0: Matrix Medicine. Dev Cell. 2017 07 10; 42(1):7-8. PMID: 28697334.
      View in: PubMed
    4. Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien K. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2017 Jan 03; 135(1):59-72. PMID: 27803039.
      View in: PubMed
    5. Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien K. Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nat Commun. 2016 Jul 19; 7:12118. PMID: 27431579; PMCID: PMC4960302.
    6. Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien K. Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nat Commun. 2016 Mar 08; 7:10774. PMID: 26952167; PMCID: PMC4786749.
    7. Ljunggren HG, Chien K. Next generation partnerships in translational science and medicine: Partnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances. EMBO Rep. 2015 Oct; 16(10):1246-9. PMID: 26358954; PMCID: PMC4766463 [Available on 10/01/16].
    8. Sahara M, Santoro F, Chien K. Programming and reprogramming a human heart cell. EMBO J. 2015 Mar 12; 34(6):710-38. PMID: 25712211; PMCID: PMC4369310.
    9. Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien K. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Res. 2015 Jan; 25(1):148. PMID: 25553820; PMCID: PMC4650595.
    10. Lui KO, Howie D, Ng SW, Liu S, Chien K, Waldmann H. Tolerance induction to human stem cell transplants with extension to their differentiated progeny. Nat Commun. 2014 Dec 01; 5:5629. PMID: 25434740.
      View in: PubMed
    11. Später D, Hansson EM, Zangi L, Chien K. How to make a cardiomyocyte. Development. 2014 Dec; 141(23):4418-31. PMID: 25406392.
      View in: PubMed
    12. Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien K. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Res. 2014 Dec; 24(12):1420-32. PMID: 25367124; PMCID: PMC4260345.
    13. Drawnel FM, Boccardo S, Prummer M, Delobel F, Graff A, Weber M, Gérard R, Badi L, Kam-Thong T, Bu L, Jiang X, Hoflack JC, Kiialainen A, Jeworutzki E, Aoyama N, Carlson C, Burcin M, Gromo G, Boehringer M, Stahlberg H, Hall BJ, Magnone MC, Kolaja K, Chien K, Bailly J, Iacone R. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. Cell Rep. 2014 Nov 06; 9(3):810-21. PMID: 25437537.
      View in: PubMed
    14. Chien K, Zangi L, Lui KO. Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine. Cold Spring Harb Perspect Med. 2014 Oct 09; 5(1):a014035. PMID: 25301935.
      View in: PubMed
    15. Lian X, Xu J, Li J, Chien K. Next-generation models of human cardiogenesis via genome editing. Cold Spring Harb Perspect Med. 2014 Sep 18; 4(12):a013920. PMID: 25237142.
      View in: PubMed
    16. Lui KO, Zangi L, Chien K. Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA. Stem Cell Res. 2014 Nov; 13(3 Pt B):693-704. PMID: 25043723.
      View in: PubMed
    17. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien K, Kelley RI, Church GM, Parker KK, Pu WT. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23. PMID: 24813252; PMCID: PMC4172922.
    18. Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien K. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Res. 2014 Jul; 24(7):820-41. PMID: 24810299; PMCID: PMC4085760.
    19. Bang ML, Gu Y, Dalton ND, Peterson KL, Chien K, Chen J. The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload. PLoS One. 2014; 9(4):e93638. PMID: 24736439; PMCID: PMC3988038.
    20. Feinberg AW, Ripplinger CM, van der Meer P, Sheehy SP, Domian I, Chien K, Parker KK. Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes. Stem Cell Reports. 2013; 1(5):387-96. PMID: 24286027; PMCID: PMC3841251.
    21. Brade T, Pane LS, Moretti A, Chien K, Laugwitz KL. Embryonic heart progenitors and cardiogenesis. Cold Spring Harb Perspect Med. 2013 Oct 01; 3(10):a013847. PMID: 24086063; PMCID: PMC3784811.
    22. Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien K. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA. Cell Res. 2013 Oct; 23(10):1172-86. PMID: 24018375; PMCID: PMC3790234.
    23. Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien K. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013 Oct; 31(10):898-907. PMID: 24013197; PMCID: PMC4058317.
    24. Yi BA, Mummery CL, Chien K. Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine. Cold Spring Harb Perspect Med. 2013 Sep 01; 3(9):a014050. PMID: 24003244; PMCID: PMC3753721.
    25. Später D, Abramczuk MK, Buac K, Zangi L, Stachel MW, Clarke J, Sahara M, Ludwig A, Chien K. A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells. Nat Cell Biol. 2013 Sep; 15(9):1098-106. PMID: 23974038.
      View in: PubMed
    26. Lian X, Chien K. The years of the monkey. Cell Res. 2013 Oct; 23(10):1161-2. PMID: 23958583; PMCID: PMC3790233.
    27. Chien K. Body, heal thyself. An interview with Kenneth Chien, Professor of Cardiovascular Research at the Department of Cell & Molecular Biology, and the Department of Medicine at Karolinska Institutet in Sweden. Interview by Holger Breithaupt. EMBO Rep. 2013 Sep; 14(9):755-8. PMID: 23938329; PMCID: PMC3790057.
    28. Chien K. Regenerative biology: heartbroken embryos heal. Nature. 2013 Jun 27; 498(7455):439-40. PMID: 23783518.
      View in: PubMed
    29. Soh BS, Wu H, Chien K. Cardiac regenerative medicine 2.0. Nat Biotechnol. 2013 Mar; 31(3):209-11. PMID: 23471068.
      View in: PubMed
    30. Hansson EM, Chien K. Reprogramming a broken heart. Cell Stem Cell. 2012 Jul 06; 11(1):3-4. PMID: 22770235.
      View in: PubMed
    31. Xu H, Yi BA, Chien K. In vivo reprogramming for heart disease. Cell Res. 2012 Nov; 22(11):1521-3. PMID: 22751090; PMCID: PMC3494388.
    32. Chien K, Yi BA, Xu H, Mummery CL. Cardiomyocyte reprogramming and the new age of cellular alchemy. J Mol Cell Cardiol. 2012 Sep; 53(3):311-3. PMID: 22749824.
      View in: PubMed
    33. Ptaszek LM, Mansour M, Ruskin JN, Chien K. Towards regenerative therapy for cardiac disease. Lancet. 2012 Mar 10; 379(9819):933-42. PMID: 22405796.
      View in: PubMed
    34. Xu H, Yi BA, Wu H, Bock C, Gu H, Lui KO, Park JH, Shao Y, Riley AK, Domian IJ, Hu E, Willette R, Lepore J, Meissner A, Wang Z, Chien K. Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. Cell Res. 2012 Jan; 22(1):142-54. PMID: 22064699; PMCID: PMC3351933.
    35. Chmielowiec J, Chang YS, Chien K. A GPS for heart progenitor cell lineages. Mol Ther. 2011 Sep; 19(9):1576-8. PMID: 21886115; PMCID: PMC3182357.
    36. Vunjak-Novakovic G, Lui KO, Tandon N, Chien K. Bioengineering heart muscle: a paradigm for regenerative medicine. Annu Rev Biomed Eng. 2011 Aug 15; 13:245-67. PMID: 21568715; PMCID: PMC3405288.
    37. Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien K. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res. 2011 Sep 16; 109(7):758-69. PMID: 21799151; PMCID: PMC3664427.
    38. Xu H, Yi BA, Chien K. Shortcuts to making cardiomyocytes. Nat Cell Biol. 2011 Mar; 13(3):191-3. PMID: 21364566.
      View in: PubMed
    39. Terada R, Warren S, Lu JT, Chien K, Wessels A, Kasahara H. Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. Cardiovasc Res. 2011 Jul 15; 91(2):289-99. PMID: 21285290; PMCID: PMC3125071.
    40. Nakano H, Williams E, Hoshijima M, Sasaki M, Minamisawa S, Chien K, Nakano A. Cardiac origin of smooth muscle cells in the inflow tract. J Mol Cell Cardiol. 2011 Feb; 50(2):337-45. PMID: 20974149; PMCID: PMC3031779.
    41. Rodin S, Domogatskaya A, Ström S, Hansson EM, Chien K, Inzunza J, Hovatta O, Tryggvason K. Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat Biotechnol. 2010 Jun; 28(6):611-5. PMID: 20512123.
      View in: PubMed
    42. Bu L, Gao X, Jiang X, Chien K, Wang Z. Targeted conditional gene knockout in human embryonic stem cells. Cell Res. 2010 Mar; 20(3):379-82. PMID: 20142843.
      View in: PubMed
    43. Yi BA, Wernet O, Chien K. Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest. 2010 Jan; 120(1):20-8. PMID: 20051633; PMCID: PMC2798699.
    44. Musunuru K, Domian IJ, Chien K. Stem cell models of cardiac development and disease. Annu Rev Cell Dev Biol. 2010; 26:667-87. PMID: 20604707; PMCID: PMC3955884.
    45. Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, Bickeböller H, Maier LS, Schaper W, Schaper J, Kraft T, Tschöpe C, Linke WA, Chien K. A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. Circ Res. 2010 Mar 05; 106(4):695-704. PMID: 20044516.
      View in: PubMed
    46. Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien K. Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science. 2009 Oct 16; 326(5951):426-9. PMID: 19833966; PMCID: PMC2895998.
    47. Hansson EM, Lindsay ME, Chien K. Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell. 2009 Oct 02; 5(4):364-77. PMID: 19796617.
      View in: PubMed
    48. Andersson KB, Finsen AV, Sjåland C, Winer LH, Sjaastad I, Odegaard A, Louch WE, Wang Y, Chen J, Chien K, Sejersted OM, Christensen G. Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models. Cell Calcium. 2009 Sep; 46(3):219-25. PMID: 19692123; PMCID: PMC4313567.
    49. Bu L, Jiang X, Martin-Puig S, Caron L, Zhu S, Shao Y, Roberts DJ, Huang PL, Domian IJ, Chien K. Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 2009 Jul 02; 460(7251):113-7. PMID: 19571884.
      View in: PubMed
    50. Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien K, Kasahara H. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Lab Invest. 2009 Sep; 89(9):983-93. PMID: 19546853; PMCID: PMC2733927.
    51. Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien K, Sejersted OM, Christensen G. Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol. 2009 Aug; 47(2):180-7. PMID: 19328205.
      View in: PubMed
    52. Risebro CA, Searles RG, Melville AA, Ehler E, Jina N, Shah S, Pallas J, Hubank M, Dillard M, Harvey NL, Schwartz RJ, Chien K, Oliver G, Riley PR. Prox1 maintains muscle structure and growth in the developing heart. Development. 2009 Feb; 136(3):495-505. PMID: 19091769; PMCID: PMC2655234.
    53. Chien K, Domian IJ, Parker KK. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science. 2008 Dec 05; 322(5907):1494-7. PMID: 19056974.
      View in: PubMed
    54. Briggs LE, Takeda M, Cuadra AE, Wakimoto H, Marks MH, Walker AJ, Seki T, Oh SP, Lu JT, Sumners C, Raizada MK, Horikoshi N, Weinberg EO, Yasui K, Ikeda Y, Chien K, Kasahara H. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circ Res. 2008 Sep 12; 103(6):580-90. PMID: 18689573; PMCID: PMC2590500.
    55. Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien K, Pu WT. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 03; 454(7200):109-13. PMID: 18568026; PMCID: PMC2574791.
    56. Adams JW, Wang J, Davis JR, Liaw C, Gaidarov I, Gatlin J, Dalton ND, Gu Y, Ross J, Behan D, Chien K, Connolly D. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H509-21. PMID: 18539757.
      View in: PubMed
    57. Geier C, Gehmlich K, Ehler E, Hassfeld S, Perrot A, Hayess K, Cardim N, Wenzel K, Erdmann B, Krackhardt F, Posch MG, Osterziel KJ, Bublak A, Nägele H, Scheffold T, Dietz R, Chien K, Spuler S, Fürst DO, Nürnberg P, Ozcelik C. Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. Hum Mol Genet. 2008 Sep 15; 17(18):2753-65. PMID: 18505755.
      View in: PubMed
    58. Chien K. Regenerative medicine and human models of human disease. Nature. 2008 May 15; 453(7193):302-5. PMID: 18480810.
      View in: PubMed
    59. Martin-Puig S, Wang Z, Chien K. Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell. 2008 Apr 10; 2(4):320-31. PMID: 18397752.
      View in: PubMed
    60. Wu SM, Chien K, Mummery C. Origins and fates of cardiovascular progenitor cells. Cell. 2008 Feb 22; 132(4):537-43. PMID: 18295570; PMCID: PMC2507768.
    61. Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien K, Melton DA. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol. 2008 Mar; 26(3):313-5. PMID: 18278034.
      View in: PubMed
    62. Ikeda Y, Hoshijima M, Chien K. Toward biologically targeted therapy of calcium cycling defects in heart failure. Physiology (Bethesda). 2008 Feb; 23:6-16. PMID: 18268360.
      View in: PubMed
    63. Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien K, Kasahara H. Identification of cardiac-specific myosin light chain kinase. Circ Res. 2008 Mar 14; 102(5):571-80. PMID: 18202317; PMCID: PMC2504503.
    64. Laugwitz KL, Moretti A, Caron L, Nakano A, Chien K. Islet1 cardiovascular progenitors: a single source for heart lineages? Development. 2008 Jan; 135(2):193-205. PMID: 18156162.
      View in: PubMed
    65. Kaye DM, Hoshijima M, Chien K. Reversing advanced heart failure by targeting Ca2+ cycling. Annu Rev Med. 2008; 59:13-28. PMID: 18186701.
      View in: PubMed
    66. Yamamoto R, Akazawa H, Ito K, Toko H, Sano M, Yasuda N, Qin Y, Kudo Y, Sugaya T, Chien K, Komuro I. Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice. Circ J. 2007 Dec; 71(12):1958-64. PMID: 18037754.
      View in: PubMed
    67. Knöll R, Postel R, Wang J, Krätzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Kube D, Knöll G, Schäfer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nürnberg P, Schultheiss HP, Schaper W, Schaper J, Bos E, Den Hertog J, van Eeden FJ, Peters PJ, Hasenfuss G, Chien K, Bakkers J. Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 2007 Jul 31; 116(5):515-25. PMID: 17646580.
      View in: PubMed
    68. Kaye DM, Preovolos A, Marshall T, Byrne M, Hoshijima M, Hajjar R, Mariani JA, Pepe S, Chien K, Power JM. Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals. J Am Coll Cardiol. 2007 Jul 17; 50(3):253-60. PMID: 17631218.
      View in: PubMed
    69. Hirai M, Horiguchi M, Ohbayashi T, Kita T, Chien K, Nakamura T. Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly. EMBO J. 2007 Jul 25; 26(14):3283-95. PMID: 17581631; PMCID: PMC1933399.
    70. Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, Moon RT, Gruber P, Evans SM, Ding S, Chien K. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 2007 Aug 16; 1(2):165-79. PMID: 18371348.
      View in: PubMed
    71. Chien K. Molecular medicine: microRNAs and the tell-tale heart. Nature. 2007 May 24; 447(7143):389-90. PMID: 17522664.
      View in: PubMed
    72. Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien K, Riley PR. Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium. Ann N Y Acad Sci. 2007 Sep; 1112:171-88. PMID: 17495252.
      View in: PubMed
    73. Hirai M, Ohbayashi T, Horiguchi M, Okawa K, Hagiwara A, Chien K, Kita T, Nakamura T. Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. J Cell Biol. 2007 Mar 26; 176(7):1061-71. PMID: 17371835; PMCID: PMC2064089.
    74. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien K, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007 Mar 09; 128(5):947-59. PMID: 17350578.
      View in: PubMed
    75. Pomiès P, Pashmforoush M, Vegezzi C, Chien K, Auffray C, Beckerle MC. The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Mol Biol Cell. 2007 May; 18(5):1723-33. PMID: 17332502; PMCID: PMC1855033.
    76. Muller O, Pradervand S, Berger S, Centeno G, Milet A, Nicod P, Pedrazzini T, Tronche F, Schütz G, Chien K, Rossier BC, Firsov D. Identification of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression. Genomics. 2007 Mar; 89(3):370-7. PMID: 17174066.
      View in: PubMed
    77. Teutsch C, Kondo RP, Dederko DA, Chrast J, Chien K, Giles WR. Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection. Cardiovasc Res. 2007 Mar 01; 73(4):739-49. PMID: 17289005.
      View in: PubMed
    78. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien K. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006 Dec 15; 127(6):1151-65. PMID: 17123592.
      View in: PubMed
    79. Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien K, Riley PR. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007 Jan 11; 445(7124):177-82. PMID: 17108969.
      View in: PubMed
    80. Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien K, Yoshimura A, Knowlton KU. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 2006 Nov 28; 114(22):2364-73. PMID: 17101849.
      View in: PubMed
    81. Hoshijima M, Knöll R, Pashmforoush M, Chien K. Reversal of calcium cycling defects in advanced heart failure toward molecular therapy. J Am Coll Cardiol. 2006 Nov 07; 48(9 Suppl 1):A15-23. PMID: 17084280.
      View in: PubMed
    82. Weissgerber P, Held B, Bloch W, Kaestner L, Chien K, Fleischmann BK, Lipp P, Flockerzi V, Freichel M. Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res. 2006 Sep 29; 99(7):749-57. PMID: 16946137.
      View in: PubMed
    83. Ricote M, Snyder CS, Leung HY, Chen J, Chien K, Glass CK. Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. J Leukoc Biol. 2006 Oct; 80(4):850-61. PMID: 16888087.
      View in: PubMed
    84. Chien K. Lost and found: cardiac stem cell therapy revisited. J Clin Invest. 2006 Jul; 116(7):1838-40. PMID: 16823485; PMCID: PMC1483159.
    85. Chien K. Herceptin and the heart--a molecular modifier of cardiac failure. N Engl J Med. 2006 Feb 23; 354(8):789-90. PMID: 16495390.
      View in: PubMed
    86. St Amand TR, Lu JT, Zamora M, Gu Y, Stricker J, Hoshijima M, Epstein JA, Ross JJ, Ruiz-Lozano P, Chien K. Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Dev Biol. 2006 Mar 15; 291(2):208-17. PMID: 16430881.
      View in: PubMed
    87. Chien K. Beyond small molecule drugs for heart failure: prospects for gene therapy. Novartis Found Symp. 2006; 274:244-56; discussion 256-9, 272-6. PMID: 17019816.
      View in: PubMed
    88. Peng X, Kraus MS, Wei H, Shen TL, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, Guan JL. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. J Clin Invest. 2006 Jan; 116(1):217-27. PMID: 16374517; PMCID: PMC1319217.
    89. Kondo RP, Dederko DA, Teutsch C, Chrast J, Catalucci D, Chien K, Giles WR. Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform. J Physiol. 2006 Feb 15; 571(Pt 1):131-46. PMID: 16357014; PMCID: PMC1805641.
    90. Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien K, Ruiz-Lozano P. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18455-60. PMID: 16352730; PMCID: PMC1317903.
    91. Wang J, Hoshijima M, Lam J, Zhou Z, Jokiel A, Dalton ND, Hultenby K, Ruiz-Lozano P, Ross J, Tryggvason K, Chien K. Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice. J Biol Chem. 2006 Jan 06; 281(1):213-20. PMID: 16204254.
      View in: PubMed
    92. Lorenzen-Schmidt I, Stuyvers BD, ter Keurs HE, Date MO, Hoshijima M, Chien K, McCulloch AD, Omens JH. Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. J Mol Cell Cardiol. 2005 Aug; 39(2):241-50. PMID: 15978612; PMCID: PMC4484861.
    93. Chien K. Alchemy and the new age of cardiac muscle cell biology. PLoS Biol. 2005 Apr; 3(4):e131. PMID: 15819607; PMCID: PMC1074813.
    94. Chien K, Karsenty G. Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. Cell. 2005 Feb 25; 120(4):533-44. PMID: 15734685.
      View in: PubMed
    95. Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien K. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10; 433(7026):647-53. PMID: 15703750.
      View in: PubMed
    96. Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien K, Ishikawa Y, Matsuoka R. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun. 2004 Dec 17; 325(3):852-6. PMID: 15541368.
      View in: PubMed
    97. Kaliman P, Catalucci D, Lam JT, Kondo R, Gutiérrez JC, Reddy S, Palacín M, Zorzano A, Chien K, Ruiz-Lozano P. Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. J Biol Chem. 2005 Mar 04; 280(9):8016-21. PMID: 15598648.
      View in: PubMed
    98. Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Choi BY, Bae SW, You CW, Han KH, Park JE, Knöll R, Hoshijima M, Chien K, Kimura A. Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol. 2004 Dec 07; 44(11):2192-201. PMID: 15582318.
      View in: PubMed
    99. Nishida K, Yamaguchi O, Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, Miyazaki J, Sudo T, Hongo K, Kusakari Y, Kurihara S, Chien K, Takeda J, Hori M, Otsu K. p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol. 2004 Dec; 24(24):10611-20. PMID: 15572667; PMCID: PMC533965.
    100. Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, Schmahl W, Chien K, Wurst W, Bornkamm GW, Brielmeier M. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol. 2004 Nov; 24(21):9414-23. PMID: 15485910; PMCID: PMC522221.
    101. Pradervand S, Yasukawa H, Muller OG, Kjekshus H, Nakamura T, St Amand TR, Yajima T, Matsumura K, Duplain H, Iwatate M, Woodard S, Pedrazzini T, Ross J, Firsov D, Rossier BC, Hoshijima M, Chien K. Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. EMBO J. 2004 Nov 10; 23(22):4517-25. PMID: 15510217; PMCID: PMC526469.
    102. Chien K, Moretti A, Laugwitz KL. Development. ES cells to the rescue. Science. 2004 Oct 08; 306(5694):239-40. PMID: 15472069.
      View in: PubMed
    103. Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T, Hikoso S, Hirotani S, Asahi M, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Miyazaki J, Chien K, Matsuzawa A, Sadamitsu C, Ichijo H, Baccarini M, Hori M, Otsu K. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest. 2004 Oct; 114(7):937-43. PMID: 15467832; PMCID: PMC518660.
    104. Smith RM, Suleman N, Lacerda L, Opie LH, Akira S, Chien K, Sack MN. Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning. Cardiovasc Res. 2004 Sep 01; 63(4):611-6. PMID: 15306216.
      View in: PubMed
    105. Chien K, Hoshijima M. Unravelling Ras signals in cardiovascular disease. Nat Cell Biol. 2004 Sep; 6(9):807-8. PMID: 15340447.
      View in: PubMed
    106. Carrier L, Knöll R, Vignier N, Keller DI, Bausero P, Prudhon B, Isnard R, Ambroisine ML, Fiszman M, Ross J, Schwartz K, Chien K. Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice. Cardiovasc Res. 2004 Aug 01; 63(2):293-304. PMID: 15249187.
      View in: PubMed
    107. Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien K, Yasukawa H, Yoshimura A. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med. 2004 Jul; 10(7):739-43. PMID: 15208705.
      View in: PubMed
    108. Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans SM, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien K. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 2004 Apr 30; 117(3):373-86. PMID: 15109497.
      View in: PubMed
    109. Chien K. Stem cells: lost in translation. Nature. 2004 Apr 08; 428(6983):607-8. PMID: 15034595.
      View in: PubMed
    110. Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien K, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004 May; 131(9):2219-31. PMID: 15073151; PMCID: PMC2628765.
    111. Chien K, Chien L. The new Silk Road. Nature. 2004 Mar 11; 428(6979):208-9. PMID: 15014508.
      View in: PubMed
    112. Iwanaga Y, Hoshijima M, Gu Y, Iwatate M, Dieterle T, Ikeda Y, Date MO, Chrast J, Matsuzaki M, Peterson KL, Chien K, Ross J. Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. J Clin Invest. 2004 Mar; 113(5):727-36. PMID: 14991071; PMCID: PMC351313.
    113. Bale TL, Hoshijima M, Gu Y, Dalton N, Anderson KR, Lee KF, Rivier J, Chien K, Vale WW, Peterson KL. The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3697-702. PMID: 14990799; PMCID: PMC373525.
    114. Kimura A, Kinjyo I, Matsumura Y, Mori H, Mashima R, Harada M, Chien K, Yasukawa H, Yoshimura A. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem. 2004 Feb 20; 279(8):6905-10. PMID: 14699146.
      View in: PubMed
    115. Knöll R, Hoshijima M, Chien K. Cardiac mechanotransduction and implications for heart disease. J Mol Med (Berl). 2003 Dec; 81(12):750-6. PMID: 14551702.
      View in: PubMed
    116. Zheng M, Dilly K, Dos Santos Cruz J, Li M, Gu Y, Ursitti JA, Chen J, Ross J, Chien K, Lederer JW, Wang Y. Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. Am J Physiol Heart Circ Physiol. 2004 Jan; 286(1):H424-33. PMID: 12969887.
      View in: PubMed
    117. Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien K, Yoshimura A. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol. 2003 Jun; 4(6):551-6. PMID: 12754507.
      View in: PubMed
    118. Chien K, Ross J, Hoshijima M. Calcium and heart failure: the cycle game. Nat Med. 2003 May; 9(5):508-9. PMID: 12724757.
      View in: PubMed
    119. Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien K, Matsuoka R. Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. J Biol Chem. 2003 Mar 14; 278(11):9570-5. PMID: 12645548.
      View in: PubMed
    120. Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien K, Omens JH, McCulloch AD. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng. 2003 Mar 05; 81(5):578-87. PMID: 12514807.
      View in: PubMed
    121. Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien K, Knowlton KU. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. J Clin Invest. 2003 Feb; 111(4):469-78. PMID: 12588885; PMCID: PMC151924.
    122. Cheng CF, Kuo HC, Chien K. Genetic modifiers of cardiac arrhythmias. Trends Mol Med. 2003 Feb; 9(2):59-66. PMID: 12615039.
      View in: PubMed
    123. Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthoff K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien K, Konnerth A, Pape HC, Biel M, Hofmann F. Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J. 2003 Jan 15; 22(2):216-24. PMID: 12514127; PMCID: PMC140107.
    124. St Amand TR, Lu JT, Chien K. Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and disease. Novartis Found Symp. 2003; 250:260-70; discussion 271-5, 276-9. PMID: 12956335.
      View in: PubMed
    125. Christensen G, Gruber PJ, Wang Y, Chien K. Embryonic and neonatal cardiac gene transfer in vivo. Methods Mol Biol. 2003; 219:169-78. PMID: 12597007.
      View in: PubMed
    126. Chien K. Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies. J Clin Invest. 2003 Jan; 111(2):175-8. PMID: 12531871; PMCID: PMC151886.
    127. Ruiz-Lozano P, Chien K. Cre-constructing the heart. Nat Genet. 2003 Jan; 33(1):8-9. PMID: 12509773.
      View in: PubMed
    128. Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien K. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002 Dec 27; 111(7):943-55. PMID: 12507422.
      View in: PubMed
    129. Hamblet NS, Lijam N, Ruiz-Lozano P, Wang J, Yang Y, Luo Z, Mei L, Chien K, Sussman DJ, Wynshaw-Boris A. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development. 2002 Dec; 129(24):5827-38. PMID: 12421720.
      View in: PubMed
    130. Jiang X, Choudhary B, Merki E, Chien K, Maxson RE, Sucov HM. Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mech Dev. 2002 Sep; 117(1-2):115-22. PMID: 12204252.
      View in: PubMed
    131. Zhao YY, Liu Y, Stan RV, Fan L, Gu Y, Dalton N, Chu PH, Peterson K, Ross J, Chien K. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11375-80. PMID: 12177436; PMCID: PMC123264.
    132. Chien K, Olson EN. Converging pathways and principles in heart development and disease: CV@CSH. Cell. 2002 Jul 26; 110(2):153-62. PMID: 12150924.
      View in: PubMed
    133. Hoshijima M, Ikeda Y, Iwanaga Y, Minamisawa S, Date MO, Gu Y, Iwatate M, Li M, Wang L, Wilson JM, Wang Y, Ross J, Chien K. Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med. 2002 Aug; 8(8):864-71. PMID: 12134142.
      View in: PubMed
    134. Ozcelik C, Erdmann B, Pilz B, Wettschureck N, Britsch S, Hübner N, Chien K, Birchmeier C, Garratt AN. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8880-5. PMID: 12072561; PMCID: PMC124392.
    135. Ferrer-Martínez A, Ruiz-Lozano P, Chien K. Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development. Dev Dyn. 2002 Jun; 224(2):154-67. PMID: 12112469.
      View in: PubMed
    136. Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J, Chien K, Lee KF. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 2002 May; 8(5):459-65. PMID: 11984589.
      View in: PubMed
    137. Hoshijima M, Chien K. Mixed signals in heart failure: cancer rules. J Clin Invest. 2002 Apr; 109(7):849-55. PMID: 11927610; PMCID: PMC150934.
    138. Ikeda Y, Gu Y, Iwanaga Y, Hoshijima M, Oh SS, Giordano FJ, Chen J, Nigro V, Peterson KL, Chien K, Ross J. Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer. Circulation. 2002 Jan 29; 105(4):502-8. PMID: 11815435.
      View in: PubMed
    139. Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J, Honjo T, Chien K. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 01 10; 415(6868):171-5. PMID: 11805835.
      View in: PubMed
    140. Knöll R, Hoshijima M, Chien K. Muscle LIM protein in heart failure. Exp Clin Cardiol. 2002; 7(2-3):104-5. PMID: 19649232; PMCID: PMC2719181.
    141. Chien K. Something old, something new, something borrowed, something blue: notes on TCM ten years after. Trends Cardiovasc Med. 2002 Jan; 12(1):1-2. PMID: 11796236.
      View in: PubMed
    Kenneth's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _