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Kevin King

Photo of Kevin King
Title(s)Associate Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000000314722189 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Illinois, Urbana ChampaignBS1999Electrical and Computer Engineering
    MIT, Cambridge, MAMS2002Electrical Engineering and Computer Science
    MIT, Cambridge, MAPhD2007Electrical Engineering and Computer Science
    Harvard Medical School, Boston, MAMD2009Doctor of Medicine
    Stanford University Hospital, Palo Alto, CA2011Internal Medicine
    Mass General Brigham, Boston, MA2014Cardiology Fellowship
    Center for Systems Biology, Boston, MA2016Cardiovascular Research

    Collapse Research 
    Collapse Featured Publications
    Collapse research activities and funding
    Understanding Early Drivers and Therapeutic Targets for Severe Forms of Arrhythmogenic Cardiomyopathy
    NIH R01HL181001Sep 1, 2025 - Jun 30, 2029
    Role: Co-Investigator
    NEK7 suppresses inflammation in the aging heart through regulation of RNA binding proteins
    NIH R21AG095645Sep 1, 2025 - Aug 31, 2027
    Role: Co-Investigator
    Biological Mechanisms of the Infarct Borderzone
    NIH R01HL181539Aug 1, 2025 - May 31, 2029
    Role: Principal Investigator
    Bed-based Non-contact Longitudinal Monitoring during Pregnancy
    Wellcome Leap In Utero Program SOWApr 1, 2024 - Sep 30, 2025
    Role: Principal Investigator
    Post-viral dynamics and dysfunction of the autonomic nervous system via adherence-independent longitudinal cardiopulmonary monitoring
    DOD HT94252410105Feb 1, 2024 - Jan 31, 2026
    Role: Principal Investigator
    Advancement of an Impending Hospitalization Detection Platform
    NIH R33HL168785Jan 1, 2024 - Dec 31, 2025
    Role: Principal Investigator
    Infusible Extracellular Matrix for Treating Myocardial Infarction
    NIH R01HL165232Jun 10, 2022 - May 31, 2026
    Role: Co-Investigator
    Non-contact In-Bed Sensing of Heart Failure Decompensation
    NIH R43HL157291Mar 15, 2021 - Mar 14, 2022
    Role: Co-Principal Investigator
    Noninvasive Adherence-independent Longitudinal Remote Chronic Disease Monitoring and Exacerbation Inference
    NIH R21NR018558Feb 20, 2020 - Jan 31, 2022
    Role: Principal Investigator
    Elucidating Cell Communication Networks during Tissue Inflammation, Fibrosis, and Regeneration
    NIH DP2AR075321Sep 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Danger Signaling and Spread of Injury after Myocardial Infarction
    NIH R00HL129168Jul 15, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Danger Signaling and Spread of Injury after Myocardial Infarction
    NIH K99HL129168Jul 15, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Development of Gap Junction Inhibition Therapy for Alcoholic Liver Disease
    NIH R43AA023707Sep 20, 2014 - Aug 31, 2016
    Role: Co-Principal Investigator
    Development of a hepatoprotective strategy for preventing drug-induced liver inju
    NIH R43DK096862Aug 21, 2013 - Jul 31, 2017
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Spatial and Single-Cell Mapping Reveals Valvular Interstitial Cell and Macrophage Sex Differences in Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2026 May 28. Baddour T, Ninh VK, Gorashi RM, Peña R, King KR, Aguado BA. PMID: 42206364; PMCID: PMC13220916.
      View in: PubMed   Mentions:    Fields:    
    2. A triple-node heart-brain neuroimmune loop underlying myocardial infarction. Cell. 2026 Feb 05; 189(3):800-817.e20. Yadav S, Ninh VK, Lovelace JW, Ma J, Pham A, Salamon RJ, Ji E, Na Y, Fu Z, Ugochukwu SI, Cui W, Sehgal R, King KR, Augustine V. PMID: 41605213.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction. Adv Healthc Mater. 2025 Dec 18; e03469. Mesfin JM, Chen A, Lyons QP, Nguyen MB, Karkanitsa ML, Yu J, Ninh VK, Gardner E, Wong EG, Paleti SN, Cheng J, Bridgelal BD, Reimold KE, Cao S, Uhre C, Luo CG, Fu Z, King KR, Christman KL. PMID: 41414646.
      View in: PubMed   Mentions:    Fields:    
    4. Regional and cell specific bioactivity of injectable extracellular matrix biomaterials in myocardial infarction. Nat Commun. 2025 Nov 24; 16(1):10387. Mesfin JM, Ninh VK, Diaz MD, Nguyen MB, Chen A, Wang RM, Wong EG, Karkanitsa ML, Hunter JD, Yu J, Bridgelal BD, Pham JA, Taghdiri N, Calcagno DM, Luo CG, Braden RL, Fu Z, King KR, Christman KL. PMID: 41285846; PMCID: PMC12644877.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. An infusible decellularized extracellular matrix material binds to vasculature in infarcted myocardium and induces pro-reparative gene expression following acute myocardial infarction through inherent avidity and bioactive signaling. bioRxiv. 2025 Nov 13. Nguyen MB, Chen A, Ninh VK, McCabe MC, Lyons Q, Luo C, Bridgelal BD, Uhre C, Cheng J, Reimold KE, Cao S, Hansen KC, King KR, Christman KL. PMID: 41292952; PMCID: PMC12642560.
      View in: PubMed   Mentions:
    6. Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction. bioRxiv. 2025 Nov 10. Mesfin JM, Chen A, Lyons QP, Nguyen MB, Karkanitsa ML, Yu J, Ninh VK, Gardner E, Wong EG, Paleti SN, Cheng J, Bridgelal BD, Reimold KE, Cao S, Uhre C, Luo CG, Fu Z, King KR, Christman KL. PMID: 41292930; PMCID: PMC12642506.
      View in: PubMed   Mentions:
    7. Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia. Science. 2025 Sep 04; 389(6764):1043-1048. Kumowski N, Pabel S, Grune J, Momin N, Ninh VK, Stengel L, Mentkowski KI, Iwamoto Y, Zheng Y, Lee IH, Matthias J, Wirth JO, Pulous FE, Seung H, Paccalet A, Muse CG, Ting KKY, Delgado P, Lewis AJM, Kaushal V, Kreso A, Brown D, Hayat S, Kramann R, Swirski FK, Naxerova K, Propheter DC, Hooper LV, Moskowitz MA, King KR, Rosenthal N, Hulsmans M, Nahrendorf M. PMID: 40906843; PMCID: PMC12805919.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Spatial transcriptomic profiling of the human aortic valve reveals cellular sex differences near sites of calcification. bioRxiv. 2025 Aug 24. Baddour T, Ninh VK, Gorashi RM, Peña R, King KR, Aguado BA. PMID: 40894684; PMCID: PMC12393613.
      View in: PubMed   Mentions:
    9. Cardiomyocyte YAP represses myocardial inflammation and fibrosis and restrains MEF2-regulated gene expression. Am J Physiol Heart Circ Physiol. 2025 Sep 01; 329(3):H774-H787. Ninh VK, Barlow M, Aydin S, Brand CS, Yu J, Smith J, Francisco J, Daneman R, King KR, Miyamoto S, Del Re DP, Brown JH. PMID: 40637445; PMCID: PMC12338972.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Spatially clustered type I interferon responses at injury borderzones. Nature. 2024 09; 633(8028):174-181. Ninh VK, Calcagno DM, Yu JD, Zhang B, Taghdiri N, Sehgal R, Mesfin JM, Chen CJ, Kalhor K, Toomu A, Duran JM, Adler E, Hu J, Zhang K, Christman KL, Fu Z, Bintu B, King KR. PMID: 39198639; PMCID: PMC11374671.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    11. Single cell transcriptomics of bone marrow derived macrophages reveals Ccl5 as a biomarker of direct IFNAR-independent responses to DNA sensing. Front Immunol. 2023; 14:1199730. McCarty E, Yu J, Ninh VK, Calcagno DM, Lee J, King KR. PMID: 37275883; PMCID: PMC10232813.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Recalling recalls: how do we interact with our patients. J Clin Sleep Med. 2023 05 01; 19(5):853-854. Owens RL, Hsu JC, King KR. PMID: 36866622; PMCID: PMC10152341.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Inferring cell communication using single-cell calcium spatiotemporal dynamics. STAR Protoc. 2022 09 16; 3(3):101647. Taghdiri N, King KR. PMID: 36065295; PMCID: PMC9440483.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. Neutrophils incite and macrophages avert electrical storm after myocardial infarction. Nat Cardiovasc Res. 2022 Jul; 1(7):649-664. Grune J, Lewis AJM, Yamazoe M, Hulsmans M, Rohde D, Xiao L, Zhang S, Ott C, Calcagno DM, Zhou Y, Timm K, Shanmuganathan M, Pulous FE, Schloss MJ, Foy BH, Capen D, Vinegoni C, Wojtkiewicz GR, Iwamoto Y, Grune T, Brown D, Higgins J, Ferreira VM, Herring N, Channon KM, Neubauer S, Oxford Acute Myocardial Infarction (OxAMI) Study, Sosnovik DE, Milan DJ, Swirski FK, King KR, Aguirre AD, Ellinor PT, Nahrendorf M. PMID: 36034743; PMCID: PMC9410341.
      View in: PubMed   Mentions: 60     Fields:    
    15. Biopsy-Proven Giant Cell Myocarditis Following the COVID-19 Vaccine. Circ Heart Fail. 2022 04; 15(4):e009321. Sung K, McCain J, King KR, Hong K, Aisagbonhi O, Adler ED, Urey MA. PMID: 35439027; PMCID: PMC9009842.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. Nocturnal Respiratory Rate Dynamics Enable Early Recognition of Impending Hospitalizations. medRxiv. 2022 Mar 14. Harrington N, Barba DT, Bui QM, Wassell A, Khurana S, Rubarth RB, Sung K, Owens RL, Agnihotri P, King KR. PMID: 35313571; PMCID: PMC8936117.
      View in: PubMed   Mentions:
    17. NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH. Hepatology. 2022 09; 76(3):727-741. Calcagno DM, Chu A, Gaul S, Taghdiri N, Toomu A, Leszczynska A, Kaufmann B, Papouchado B, Wree A, Geisler L, Hoffman HM, Feldstein AE, King KR. PMID: 34997987; PMCID: PMC10176600.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    18. Passive longitudinal weight and cardiopulmonary monitoring in the home bed. Sci Rep. 2021 12 21; 11(1):24376. Harrington N, Bui QM, Wei Z, Hernandez-Pacheco B, DeYoung PN, Wassell A, Duwaik B, Desai AS, Bhatt DL, Agnihotri P, Owens RL, Coleman TP, King KR. PMID: 34934065; PMCID: PMC8692625.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    19. Macrophage calcium reporter mice reveal immune cell communication in vitro and in vivo. Cell Rep Methods. 2021 12 20; 1(8). Taghdiri N, Calcagno DM, Fu Z, Huang K, Kohler RH, Weissleder R, Coleman TP, King KR. PMID: 35079727; PMCID: PMC8786215.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Low mortality in SARS-CoV-2 infected heart transplant recipients at a single center. Clin Transplant. 2022 01; 36(1):e14443. Duran JM, Barat M, Lin AY, King KR, Greenberg B, Adler ED, Aslam S. PMID: 34320235; PMCID: PMC8420241.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    21. SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification. J Am Heart Assoc. 2021 02 16; 10(4):e019019. Calcagno DM, Zhang C, Toomu A, Huang K, Ninh VK, Miyamoto S, Aguirre AD, Fu Z, Heller Brown J, King KR. PMID: 33525909; PMCID: PMC7955351.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    22. The Power of Single-Cell Analysis for the Study of Liver Pathobiology. Hepatology. 2021 01; 73(1):437-448. Chu AL, Schilling JD, King KR, Feldstein AE. PMID: 32740968; PMCID: PMC7854989.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    23. The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages. Sci Immunol. 2020 09 25; 5(51). Calcagno DM, Ng RP, Toomu A, Zhang C, Huang K, Aguirre AD, Weissleder R, Daniels LB, Fu Z, King KR. PMID: 32978242; PMCID: PMC7808338.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    24. Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation. Proc Natl Acad Sci U S A. 2020 05 26; 117(21):11667-11673. Luther J, Khan S, Gala MK, Kedrin D, Sridharan G, Goodman RP, Garber JJ, Masia R, Diagacomo E, Adams D, King KR, Piaker S, Reinecker HC, Yarmush ML, Argemi J, Bataller R, Dienstag JL, Chung RT, Patel SJ. PMID: 32393626; PMCID: PMC7261084.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    25. Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge. Immunity. 2019 11 19; 51(5):899-914.e7. Hoyer FF, Naxerova K, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M. PMID: 31732166; PMCID: PMC6892583.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    26. A Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse. Circ Res. 2018 11 09; 123(11):1208-1219. Hulsmans M, Aguirre AD, Bonner MD, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M. PMID: 30571465; PMCID: PMC6309285.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    27. IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nat Med. 2017 Dec; 23(12):1481-1487. King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R. PMID: 29106401; PMCID: PMC6477926.
      View in: PubMed   Mentions: 308     Fields:    Translation:AnimalsCells
    28. Stunning neutrophils changes the forecast: No more showers. Sci Transl Med. 2017 05 03; 9(388). King KR. PMID: 28469035.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    29. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017 04 20; 169(3):510-522.e20. Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M. PMID: 28431249; PMCID: PMC5474950.
      View in: PubMed   Mentions: 563     Fields:    Translation:HumansAnimalsCells
    30. Squeeze-E squeeze-E. Sci Transl Med. 2017 03 22; 9(382). King KR. PMID: 28330860.
      View in: PubMed   Mentions:    Fields:    
    31. A Novel Resolvin-Based Strategy for Limiting Acetaminophen Hepatotoxicity. Clin Transl Gastroenterol. 2016 Mar 17; 7:e153. Patel SJ, Luther J, Bohr S, Iracheta-Vellve A, Li M, King KR, Chung RT, Yarmush ML. PMID: 26986653; PMCID: PMC4822092.
      View in: PubMed   Mentions: 18     Fields:    
    32. The inflammatory response to double stranded DNA in endothelial cells is mediated by NFκB and TNFα. PLoS One. 2011; 6(5):e19910. Patel SJ, Jindal R, King KR, Tilles AW, Yarmush ML. PMID: 21611132; PMCID: PMC3097212.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. High throughput single cell bioinformatics. Biotechnol Prog. 2009 Nov-Dec; 25(6):1772-9. Roach KL, King KR, Uygun BE, Kohane IS, Yarmush ML, Toner M. PMID: 19830811; PMCID: PMC3208255.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    34. DNA-triggered innate immune responses are propagated by gap junction communication. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12867-72. Patel SJ, King KR, Casali M, Yarmush ML. PMID: 19617563; PMCID: PMC2722330.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    35. Development of an in vitro cell culture model of hepatic steatosis using hepatocyte-derived reporter cells. Biotechnol Bioeng. 2009 Apr 01; 102(5):1466-74. Janorkar AV, King KR, Megeed Z, Yarmush ML. PMID: 19061238; PMCID: PMC4490792.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    36. High-throughput single cell arrays as a novel tool in biopreservation. Cryobiology. 2009 Jun; 58(3):315-21. Roach KL, King KR, Uygun K, Hand SC, Kohane IS, Yarmush ML, Toner M. PMID: 19303403; PMCID: PMC2717893.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    37. Living-cell microarrays. Annu Rev Biomed Eng. 2009; 11:235-57. Yarmush ML, King KR. PMID: 19413510; PMCID: PMC3208259.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    38. A high-throughput microfluidic real-time gene expression living cell array. Lab Chip. 2007 Jan; 7(1):77-85. King KR, Wang S, Irimia D, Jayaraman A, Toner M, Yarmush ML. PMID: 17180208; PMCID: PMC3205973.
      View in: PubMed   Mentions: 70     Fields:    Translation:Cells
    39. Optimization of reporter cells for expression profiling in a microfluidic device. Biomed Microdevices. 2005 Sep; 7(3):213-22. Wieder KJ, King KR, Thompson DM, Zia C, Yarmush ML, Jayaraman A. PMID: 16133809.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    40. Dynamic gene expression profiling using a microfabricated living cell array. Anal Chem. 2004 Jul 15; 76(14):4098-103. Thompson DM, King KR, Wieder KJ, Toner M, Yarmush ML, Jayaraman A. PMID: 15253648.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
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