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    Taylor Doherty

    TitleAssociate Professor In Residence
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0635
    CA La Jolla 92093
    Phone858-822-7563
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      Collapse Research 
      Collapse Research Activities and Funding
      RBM3 regulation of type 2 innate lymphoid cells in allergic inflammation
      NIH/NIAID R01AI114585Nov 10, 2014 - Oct 31, 2019
      Role: Principal Investigator
      OX40/OX40L interactions in allergen-induced airway inflammation and remodeling
      NIH/NIAID K08AI080938Aug 16, 2010 - Jul 31, 2015
      Role: Principal Investigator
      Airway inflammation and airway remodeling
      NIH/NIAID U19AI070535Jul 1, 2006 - Aug 31, 2021
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Cavagnero K, Doherty T. Cytokine and Lipid Mediator Regulation of Group 2 Innate Lymphoid Cells (ILC2s) in Human Allergic Airway Disease. J Cytokine Biol. 2017 Aug; 2(2). PMID: 28959799.
        View in: PubMed
      2. Lund SJ, Portillo A, Cavagnero K, Baum RE, Naji LH, Badrani JH, Mehta A, Croft M, Broide DH, Doherty T. Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation. J Immunol. 2017 Aug 01; 199(3):1096-1104. PMID: 28667163.
        View in: PubMed
      3. Karta MR, Rosenthal PS, Beppu A, Vuong CY, Miller M, Das S, Kurten RC, Doherty T, Broide DH. ß2 integrins rather than ß1 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung. J Allergy Clin Immunol. 2017 Mar 30. PMID: 28366795.
        View in: PubMed
      4. Miller M, Tam AB, Mueller JL, Rosenthal P, Beppu A, Gordillo R, McGeough MD, Vuong C, Doherty T, Hoffman HM, Niwa M, Broide DH. Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. J Immunol. 2017 Apr 15; 198(8):3017-3022. PMID: 28275141.
        View in: PubMed
      5. Doherty T, Broide DH. Pathways to limit group 2 innate lymphoid cell activation. J Allergy Clin Immunol. 2017 Jan 10. PMID: 28087226.
        View in: PubMed
      6. Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty T, Kurten RC, Hamid Q, Hoffman HM, Broide DH. GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46):13132-13137. PMID: 27799535.
        View in: PubMed
      7. Kim AS, Doherty T, Karta MR, Das S, Baum R, Rosenthal P, Beppu A, Miller M, Kurten R, Broide DH. Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis. J Allergy Clin Immunol. 2016 Oct; 138(4):1192-1195.e5. PMID: 27142393.
        View in: PubMed
      8. Kim AS, Doherty T. New and emerging therapies for asthma. Ann Allergy Asthma Immunol. 2016 Jan; 116(1):14-7. PMID: 26707770; PMCID: PMC4693149 [Available on 01/01/17].
      9. Karta MR, Broide DH, Doherty T. Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease. Curr Allergy Asthma Rep. 2016 Jan; 16(1):8. PMID: 26746844; PMCID: PMC5026503.
      10. Tkachenko E, Rawson R, La E, Doherty T, Baum R, Cavagnero K, Miyanohara A, Dohil R, Kurten RC, Aceves SS. Rigid substrate induces esophageal smooth muscle hypertrophy and eosinophilic esophagitis fibrotic gene expression. J Allergy Clin Immunol. 2016 Apr; 137(4):1270-1272.e1. PMID: 26542032; PMCID: PMC4826849 [Available on 04/01/17].
      11. Miller M, Beppu A, Rosenthal P, Pham A, Das S, Karta M, Song DJ, Vuong C, Doherty T, Croft M, Zuraw B, Zhang X, Gao X, Aceves S, Chouiali F, Hamid Q, Broide DH. Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M. J Immunol. 2015 Oct 15; 195(8):3546-56. PMID: 26355153; PMCID: PMC4811198 [Available on 10/15/16].
      12. Doherty T, Baum R, Newbury RO, Yang T, Dohil R, Aquino M, Doshi A, Walford HH, Kurten RC, Broide DH, Aceves S. Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis. J Allergy Clin Immunol. 2015 Sep; 136(3):792-794.e3. PMID: 26233928; PMCID: PMC4562810.
      13. Doherty T, Broide DH. Group 2 innate lymphoid cells: new players in human allergic diseases. J Investig Allergol Clin Immunol. 2015; 25(1):1-11; quiz 2p following 11. PMID: 25898689; PMCID: PMC4545833.
      14. Doherty T. At the bench: understanding group 2 innate lymphoid cells in disease. J Leukoc Biol. 2015 Mar; 97(3):455-67. PMID: 25473099; PMCID: PMC4338843.
      15. Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty T, Lange S, del Álamo JC, Nigam V. Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-ß signaling. J Mol Cell Cardiol. 2015 Feb; 79:133-44. PMID: 25446186; PMCID: PMC4302020.
      16. Walford HH, Lund SJ, Baum RE, White AA, Bergeron CM, Husseman J, Bethel KJ, Scott DR, Khorram N, Miller M, Broide DH, Doherty T. Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness. Clin Immunol. 2014 Nov; 155(1):126-35. PMID: 25236785; PMCID: PMC4254351.
      17. Walford HH, Doherty T. Diagnosis and management of eosinophilic asthma: a US perspective. J Asthma Allergy. 2014; 7:53-65. PMID: 24748808; PMCID: PMC3990389.
      18. Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, Doherty T, McGeough MD, Pena CA, Suzukawa M, Niwa M, Broide DH. ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma. J Immunol. 2014 Apr 15; 192(8):3475-87. PMID: 24623133; PMCID: PMC3981544.
      19. Doherty T, Scott D, Walford HH, Khorram N, Lund S, Baum R, Chang J, Rosenthal P, Beppu A, Miller M, Broide DH. Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84. J Allergy Clin Immunol. 2014 Apr; 133(4):1203-5. PMID: 24582313; PMCID: PMC3972276.
      20. Kim HK, Lund S, Baum R, Rosenthal P, Khorram N, Doherty T. Innate type 2 response to Alternaria extract enhances ryegrass-induced lung inflammation. Int Arch Allergy Immunol. 2014; 163(2):92-105. PMID: 24296722; PMCID: PMC3946274.
      21. Chang JE, Doherty T, Baum R, Broide D. Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis. J Allergy Clin Immunol. 2014 Mar; 133(3):899-901.e3. PMID: 24210841; PMCID: PMC3943597.
      22. Lund S, Walford HH, Doherty T. Type 2 Innate Lymphoid Cells in Allergic Disease. Curr Immunol Rev. 2013 Nov; 9(4):214-221. PMID: 24876829.
        View in: PubMed
      23. Kim HK, Baum R, Lund S, Khorram N, Yang SL, Chung KR, Doherty T. Impaired induction of allergic lung inflammation by Alternaria alternata mutant MAPK homologue Fus3. Exp Lung Res. 2013 Nov; 39(9):399-409. PMID: 24102366; PMCID: PMC4079010.
      24. Walford HH, Doherty T. STAT6 and lung inflammation. JAKSTAT. 2013 Oct 01; 2(4):e25301. PMID: 24416647; PMCID: PMC3876430.
      25. Doherty T, Khorram N, Lund S, Mehta AK, Croft M, Broide DH. Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. J Allergy Clin Immunol. 2013 Jul; 132(1):205-13. PMID: 23688412; PMCID: PMC3704056.
      26. Suzukawa M, Miller M, Rosenthal P, Cho JY, Doherty T, Varki A, Broide D. Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice. J Immunol. 2013 Jun 15; 190(12):5939-48. PMID: 23677475; PMCID: PMC3679360.
      27. Soroosh P, Doherty T, Duan W, Mehta AK, Choi H, Adams YF, Mikulski Z, Khorram N, Rosenthal P, Broide DH, Croft M. Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance. J Exp Med. 2013 Apr 08; 210(4):775-88. PMID: 23547101; PMCID: PMC3620360.
      28. Miller M, Tam AB, Cho JY, Doherty T, Pham A, Khorram N, Rosenthal P, Mueller JL, Hoffman HM, Suzukawa M, Niwa M, Broide DH. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16648-53. PMID: 23011799; PMCID: PMC3478632.
      29. Doherty T, Khorram N, Chang JE, Kim HK, Rosenthal P, Croft M, Broide DH. STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 01; 303(7):L577-88. PMID: 22865552; PMCID: PMC3469584.
      30. Doherty T, Khorram N, Sugimoto K, Sheppard D, Rosenthal P, Cho JY, Pham A, Miller M, Croft M, Broide DH. Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol. 2012 Mar 15; 188(6):2622-9. PMID: 22327070; PMCID: PMC3294141.
      31. Doherty T, Croft M. Therapeutic potential of targeting TNF/TNFR family members in asthma. Immunotherapy. 2011 Aug; 3(8):919-21. PMID: 21843077.
        View in: PubMed
      32. Doherty T, Soroosh P, Khorram N, Fukuyama S, Rosenthal P, Cho JY, Norris PS, Choi H, Scheu S, Pfeffer K, Zuraw BL, Ware CF, Broide DH, Croft M. The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med. 2011 May; 17(5):596-603. PMID: 21499267; PMCID: PMC3097134.
      33. Soroosh P, Doherty T, So T, Mehta AK, Khorram N, Norris PS, Scheu S, Pfeffer K, Ware C, Croft M. Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations. J Exp Med. 2011 Apr 11; 208(4):797-809. PMID: 21402741; PMCID: PMC3135347.
      34. Cho JY, Pham A, Rosenthal P, Miller M, Doherty T, Broide DH. Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling. Int Immunopharmacol. 2011 Aug; 11(8):1038-44. PMID: 21382533; PMCID: PMC3121895.
      35. Doherty T, Brydges SD, Hoffman HM. Autoinflammation: translating mechanism to therapy. J Leukoc Biol. 2011 Jul; 90(1):37-47. PMID: 21330349; PMCID: PMC3219035.
      36. Tourangeau LM, Doherty T. Cardiopulmonary arrest in a patient with delayed diagnosis of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Allergy Asthma Proc. 2011 Jan-Feb; 32(1):74-8. PMID: 21262102.
        View in: PubMed
      37. Cho JY, Song DJ, Pham A, Rosenthal P, Miller M, Dayan S, Doherty T, Varki A, Broide DH. Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13. Respir Res. 2010 Nov 01; 11:154. PMID: 21040544; PMCID: PMC2988013.
      38. Soroosh P, Doherty T. Th9 and allergic disease. Immunology. 2009 Aug; 127(4):450-8. PMID: 19604299; PMCID: PMC2729522.
      39. Doherty T, Soroosh P, Broide DH, Croft M. CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling. Am J Physiol Lung Cell Mol Physiol. 2009 Feb; 296(2):L229-35. PMID: 19060225; PMCID: PMC2643996.
      40. Doherty T, Broide D. Cytokines and growth factors in airway remodeling in asthma. Curr Opin Immunol. 2007 Dec; 19(6):676-80. PMID: 17720466.
        View in: PubMed
      41. Ruiz PJ, Masliah E, Doherty T, Quach A, Firestein GS. Cardiac death in a patient with adult-onset Still's disease treated with the interleukin 1 receptor inhibitor anakinra. Ann Rheum Dis. 2007 Mar; 66(3):422-3. PMID: 17179171; PMCID: PMC1856013.
      42. Broide DH, Lawrence T, Doherty T, Cho JY, Miller M, McElwain K, McElwain S, Karin M. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17723-8. PMID: 16317067; PMCID: PMC1308936.
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