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    Dianne Mckay

    TitleTeacher
    SchoolUniversity of California, San Diego
    Address9300 Campus Point Drive #7745
    CA La Jolla 92037
    Phone858-657-8044
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      Collapse Research 
      Collapse Research Activities and Funding
      Role of NOD2 in ischemia reperfusion injury
      NIH/NIDDK R01DK113162Apr 1, 2017 - Mar 31, 2021
      Role: Principal Investigator
      Role of Nlrp3 in Ischemic Organ Injury
      NIH/NIDDK R01DK091136Sep 15, 2011 - Aug 31, 2016
      Role: Principal Investigator
      The Role of Inflammation in Ischemic Organ Injury
      NIH/NIDDK R01DK075718Feb 1, 2008 - Jan 31, 2014
      Role: Principal Investigator
      Donor Antigen-Induced Peripheral Tolerance
      NIH/NIDDK R01DK062135Sep 1, 2002 - Mar 31, 2008
      Role: Principal Investigator
      MECHANISMS OF IN VIVO T CELL UNRESPONSIVENESS
      NIH/NIDDK R03DK058814Sep 30, 2000 - Aug 31, 2003
      Role: Principal Investigator
      TOLERANCE MECHANISMS--KIDNEY AND HEART TRANSPLANTATION
      NIH/NIDDK K08DK002472Aug 30, 1997 - Jun 30, 2003
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kasimsetty SG, Shigeoka AA, Scheinok AA, Gavin AL, Ulevitch RJ, McKay DB. Lack of Both Nucleotide-Binding Oligomerization Domain-Containing Proteins 1 and 2 Primes T Cells for Activation-Induced Cell Death. J Immunol. 2017 Aug 01; 199(3):1196-1205. PMID: 28652394.
        View in: PubMed
      2. DeWolf SE, Shigeoka AA, Scheinok A, Kasimsetty SG, Welch AK, McKay DB. Expression of TLR2, NOD1, and NOD2 and the NLRP3 Inflammasome in Renal Tubular Epithelial Cells of Male versus Female Mice. Nephron. 2017; 137(1):68-76. PMID: 28614830.
        View in: PubMed
      3. Dutt SB, Gonzales J, Boyett M, Costanzo A, Han PP, Steinberg S, McKay DB, Jameson JM. mTOR Inhibition by Everolimus Does Not Impair Closure of Punch Biopsy Wounds in Renal Transplant Patients. Transplant Direct. 2017 Apr; 3(4):e147. PMID: 28405603.
        View in: PubMed
      4. Momper JD, Misel ML, McKay DB. Sex differences in transplantation. Transplant Rev (Orlando). 2017 Jul; 31(3):145-150. PMID: 28262425.
        View in: PubMed
      5. Martinic MM, Caminschi I, O'Keeffe M, Thinnes TC, Grumont R, Gerondakis S, McKay DB, Nemazee D, Gavin AL. The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8+ Thymocyte Selection. J Immunol. 2017 Apr 01; 198(7):2649-2660. PMID: 28202617.
        View in: PubMed
      6. Webster P, Lightstone L, McKay DB, Josephson MA. Pregnancy in chronic kidney disease and kidney transplantation. Kidney Int. 2017 May; 91(5):1047-1056. PMID: 28209334.
        View in: PubMed
      7. Ix JH, Katz R, Bansal N, Foster M, Weiner DE, Tracy R, Jotwani V, Hughes-Austin J, McKay D, Gabbai F, Hsu CY, Bostom A, Levey AS, Shlipak MG. Urine Fibrosis Markers and Risk of Allograft Failure in Kidney Transplant Recipients: A Case-Cohort Ancillary Study of the FAVORIT Trial. Am J Kidney Dis. 2017 Mar; 69(3):410-419. PMID: 28024930.
        View in: PubMed
      8. Elahimehr R, Scheinok AT, McKay DB. Hematopoietic stem cells and solid organ transplantation. Transplant Rev (Orlando). 2016 Oct; 30(4):227-34. PMID: 27553809.
        View in: PubMed
      9. Kasimsetty SG, McKay DB. Ischemia as a factor affecting innate immune responses in kidney transplantation. Curr Opin Nephrol Hypertens. 2016 Jan; 25(1):3-11. PMID: 26625866; PMCID: PMC4744806 [Available on 01/01/17].
      10. Ratigan ED, McKay DB. Exploring principles of hibernation for organ preservation. Transplant Rev (Orlando). 2016 Jan; 30(1):13-9. PMID: 26613668.
        View in: PubMed
      11. Kasimsetty SG, Scheinok AT, Shigeoka AA, McKay DB. Simultaneous deletion of NOD1 and NOD2 inhibits in vitro alloresponses but does not prevent allograft rejection. Immunobiology. 2015 Nov; 220(11):1227-31. PMID: 26159289; PMCID: PMC4558238 [Available on 11/01/16].
      12. Kasimsetty SG, DeWolf SE, Shigeoka AA, McKay DB. Regulation of TLR2 and NLRP3 in primary murine renal tubular epithelial cells. Nephron Clin Pract. 2014; 127(1-4):119-23. PMID: 25343834; PMCID: PMC4896108.
      13. Cheung KP, Kasimsetty SG, McKay DB. Innate immunity in donor procurement. Curr Opin Organ Transplant. 2013 Apr; 18(2):154-60. PMID: 23313940; PMCID: PMC4515366.
      14. McKay D, Jameson J. Kidney transplantation and the ageing immune system. Nat Rev Nephrol. 2012 Dec; 8(12):700-8. PMID: 23147756.
        View in: PubMed
      15. Rutschmann S, Crozat K, Li X, Du X, Hanselman JC, Shigeoka AA, Brandl K, Popkin DL, McKay DB, Xia Y, Moresco EM, Beutler B. Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice. G3 (Bethesda). 2012 Apr; 2(4):499-504. PMID: 22540041; PMCID: PMC3337478.
      16. McKay DB. The role of innate immunity in donor organ procurement. Semin Immunopathol. 2011 Mar; 33(2):169-84. PMID: 21424913.
        View in: PubMed
      17. McKay DB. Intracellular pattern recognition receptors and renal ischemia. Crit Rev Immunol. 2011; 31(4):297-306. PMID: 21899512.
        View in: PubMed
      18. Shigeoka AA, Mueller JL, Kambo A, Mathison JC, King AJ, Hall WF, Correia Jda S, Ulevitch RJ, Hoffman HM, McKay DB. An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury. J Immunol. 2010 Nov 15; 185(10):6277-85. PMID: 20962258; PMCID: PMC3020135.
      19. Josephson MA, McKay DB. Pregnancy in the renal transplant recipient. Obstet Gynecol Clin North Am. 2010 Jun; 37(2):211-22. PMID: 20685549.
        View in: PubMed
      20. Shigeoka AA, Kambo A, Mathison JC, King AJ, Hall WF, da Silva Correia J, Ulevitch RJ, McKay DB. Nod1 and nod2 are expressed in human and murine renal tubular epithelial cells and participate in renal ischemia reperfusion injury. J Immunol. 2010 Mar 01; 184(5):2297-304. PMID: 20124104; PMCID: PMC3020136.
      21. Mills RE, Taylor KR, Podshivalova K, McKay DB, Jameson JM. Defects in skin gamma delta T cell function contribute to delayed wound repair in rapamycin-treated mice. J Immunol. 2008 Sep 15; 181(6):3974-83. PMID: 18768852; PMCID: PMC2547144.
      22. McKay D, Potter SR, Behrend T, Stella F, Steinberg S. Patients seeking alternatives to the long waiting list: a reality faced by transplant physicians. Prog Transplant. 2008 Sep; 18(3):203-7. PMID: 18831487.
        View in: PubMed
      23. Shigeoka AA, Holscher TD, King AJ, Hall FW, Kiosses WB, Tobias PS, Mackman N, McKay DB. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways. J Immunol. 2007 May 15; 178(10):6252-8. PMID: 17475853.
        View in: PubMed
      24. Josephson MA, McKay DB. Considerations in the medical management of pregnancy in transplant recipients. Adv Chronic Kidney Dis. 2007 Apr; 14(2):156-67. PMID: 17395118.
        View in: PubMed
      25. McKay D, Shigeoka A, Rubinstein M, Surh C, Sprent J. Simultaneous deletion of MyD88 and Trif delays major histocompatibility and minor antigen mismatch allograft rejection. Eur J Immunol. 2006 Aug; 36(8):1994-2002. PMID: 16874736.
        View in: PubMed
      26. McKay DB, Adams PL, Bumgardner GL, Davis CL, Fine RN, Krams SM, Martinez OM, Murphy B, Pavlakis M, Tolkoff-Rubin N, Sherman MS, Josephson MA. Reproduction and pregnancy in transplant recipients: current practices. Prog Transplant. 2006 Jun; 16(2):127-32. PMID: 16789701.
        View in: PubMed
      27. Zambricki E, Shigeoka A, Kishimoto H, Sprent J, Burakoff S, Carpenter C, Milford E, McKay D. Signaling T-cell survival and death by IL-2 and IL-15. Am J Transplant. 2005 Nov; 5(11):2623-31. PMID: 16212621.
        View in: PubMed
      28. McKay DB, Josephson MA, Armenti VT, August P, Coscia LA, Davis CL, Davison JM, Easterling T, Friedman JE, Hou S, Karlix J, Lake KD, Lindheimer M, Matas AJ, Moritz MJ, Riely CA, Ross LF, Scott JR, Wagoner LE, Wrenshall L, Adams PL, Bumgardner GL, Fine RN, Goral S, Krams SM, Martinez OM, Tolkoff-Rubin N, Pavlakis M, Scantlebury V. Reproduction and transplantation: report on the AST Consensus Conference on Reproductive Issues and Transplantation. Am J Transplant. 2005 Jul; 5(7):1592-9. PMID: 15943616.
        View in: PubMed
      29. Rubel JR, Milford EL, McKay DB, Jarcho JA. Renal insufficiency and end-stage renal disease in the heart transplant population. J Heart Lung Transplant. 2004 Mar; 23(3):289-300. PMID: 15019638.
        View in: PubMed
      30. Tkaczuk J, Yu CL, Baksh S, Milford EL, Carpenter CB, Burakoff SJ, McKay DB. Effect of anti-IL-2Ralpha antibody on IL-2-induced Jak/STAT signaling. Am J Transplant. 2002 Jan; 2(1):31-40. PMID: 12095053.
        View in: PubMed
      31. Tran HT, Acharya MK, McKay DB, Sayegh MH, Carpenter CB, Auchincloss H JR, Kirkman RL, Milford EL. Avoidance of cyclosporine in renal transplantation: effects of daclizumab, mycophenolate mofetil, and steroids. J Am Soc Nephrol. 2000 Oct; 11(10):1903-9. PMID: 11004222.
        View in: PubMed
      32. McKay DB, Irie HY, Hollander G, Ferrara JL, Strom TB, Li Y, Burakoff SJ. Antigen-induced unresponsiveness results in altered T cell signaling. J Immunol. 1999 Dec 15; 163(12):6455-61. PMID: 10586036.
        View in: PubMed
      33. McKay DB, Milford EL, Carpenter CB, Kartashov AI, Schoen FJ, Loh E, Aranki SF, Couper GS, Mudge GH. T cell activation in cardiac transplant recipients. Transplantation. 1994 Jul 27; 58(2):241-5. PMID: 8042242.
        View in: PubMed
      34. McKay DB, Vazquez MA, Redline RW, Lu CY. Macrophage functions are regulated by murine decidual and tumor extracellular matrices. J Clin Invest. 1992 Jan; 89(1):134-42. PMID: 1729266; PMCID: PMC442828.
      35. Kirkman RL, Shapiro ME, Carpenter CB, McKay DB, Milford EL, Ramos EL, Tilney NL, Waldmann TA, Zimmerman CE, Strom TB. A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation. Transplant Proc. 1991 Feb; 23(1 Pt 2):1066-7. PMID: 1989150.
        View in: PubMed
      36. Kirkman RL, Shapiro ME, Carpenter CB, McKay DB, Milford EL, Ramos EL, Tilney NL, Waldmann TA, Zimmerman CE, Strom TB. A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation. Transplantation. 1991 Jan; 51(1):107-13. PMID: 1846250.
        View in: PubMed
      37. Redline RW, McKay DB, Vazquez MA, Papaioannou VE, Lu CY. Macrophage functions are regulated by the substratum of murine decidual stromal cells. J Clin Invest. 1990 Jun; 85(6):1951-8. PMID: 2347918; PMCID: PMC296663.
      38. Lu CY, Redline RW, Shea CM, Dustin LB, McKay DB. Pregnancy as a natural model of allograft tolerance. Interactions between adherent macrophages and trophoblast populations. Transplantation. 1989 Nov; 48(5):848-55. PMID: 2573182.
        View in: PubMed