Emily Troemel

InstitutionUniversity of California San Diego
DepartmentCell and Developmental Biology
Address9500 Gilman Drive #0349
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Probing organismal proteostasis through the response to intracellular infection
    NIH/NIA R01AG052622Aug 1, 2017 - May 31, 2020
    Role: Principal Investigator
    Probing organismal proteostasis through the response to intracellular infection
    NIH/NIA R56AG052622Sep 30, 2016 - Aug 31, 2017
    Role: Principal Investigator
    Perturbation of core processes triggers host defense against pathogens
    NIH/NIGMS R01GM114139Aug 1, 2015 - Jul 31, 2019
    Role: Principal Investigator
    A natural host model for microsporidia pathogenesis in the intestine
    NIH/NIAID R01AI087528Jan 15, 2010 - Dec 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kuo CJ, Hansen M, Troemel E. Autophagy and innate immunity: Insights from invertebrate model organisms. Autophagy. 2018; 14(2):233-242. PMID: 29130360.
      View in: PubMed
    2. Reddy KC, Dror T, Sowa JN, Panek J, Chen K, Lim ES, Wang D, Troemel E. An Intracellular Pathogen Response Pathway Promotes Proteostasis in C. elegans. Curr Biol. 2017 Nov 20; 27(22):3544-3553.e5. PMID: 29103937.
      View in: PubMed
    3. Reinke AW, Mak R, Troemel E, Bennett EJ. In vivo mapping of tissue- and subcellular-specific proteomes in Caenorhabditis elegans. Sci Adv. 2017 May; 3(5):e1602426. PMID: 28508060.
      View in: PubMed
    4. Reinke AW, Balla KM, Bennett EJ, Troemel E. Identification of microsporidia host-exposed proteins reveals a repertoire of rapidly evolving proteins. Nat Commun. 2017 Jan 09; 8:14023. PMID: 28067236.
      View in: PubMed
    5. Zhang G, Sachse M, Prevost MC, Luallen RJ, Troemel E, Félix MA. A Large Collection of Novel Nematode-Infecting Microsporidia and Their Diverse Interactions with Caenorhabditis elegans and Other Related Nematodes. PLoS Pathog. 2016 Dec; 12(12):e1006093. PMID: 27942022.
      View in: PubMed
    6. Troemel E. Host-Microsporidia Interactions in Caenorhabditis elegans, a Model Nematode Host. Microbiol Spectr. 2016 10; 4(5). PMID: 27763260.
      View in: PubMed
    7. Botts MR, Cohen LB, Probert CS, Wu F, Troemel E. Microsporidia Intracellular Development Relies on Myc Interaction Network Transcription Factors in the Host. G3 (Bethesda). 2016 09 08; 6(9):2707-16. PMID: 27402359; PMCID: PMC5015929.
    8. Balla KM, Luallen RJ, Bakowski MA, Troemel E. Cell-to-cell spread of microsporidia causes Caenorhabditis elegans organs to form syncytia. Nat Microbiol. 2016 Aug 22; 1(11):16144. PMID: 27782144.
      View in: PubMed
    9. Ma Q, Khademhosseinieh B, Huang E, Qian H, Bakowski MA, Troemel E, Liu Z. Three-dimensional fluorescent microscopy via simultaneous illumination and detection at multiple planes. Sci Rep. 2016 08 16; 6:31445. PMID: 27527813.
      View in: PubMed
    10. Luallen RJ, Reinke AW, Tong L, Botts MR, Félix MA, Troemel E. Discovery of a Natural Microsporidian Pathogen with a Broad Tissue Tropism in Caenorhabditis elegans. PLoS Pathog. 2016 Jun; 12(6):e1005724. PMID: 27362540; PMCID: PMC4928854.
    11. Stentiford GD, Becnel JJ, Weiss LM, Keeling PJ, Didier ES, Williams BAP, Bjornson S, Kent ML, Freeman MA, Brown MJF, Troemel E, Roesel K, Sokolova Y, Snowden KF, Solter LF. Microsporidia-Emergent Pathogens in the Global Food Chain (Trends in Parasitology 32, 336-348; April 2, 2016). Trends Parasitol. 2016 Aug; 32(8):657. PMID: 27365191.
      View in: PubMed
    12. Reddy KC, Dunbar TL, Nargund AM, Haynes CM, Troemel E. The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity. Cell Rep. 2016 Feb 23; 14(7):1581-1589. PMID: 26876169; PMCID: PMC4767654.
    13. Stentiford GD, Becnel -J, Weiss LM, Keeling PJ, Didier ES, Williams BP, Bjornson S, Kent ML, Freeman MA, Brown MJF, Troemel E, Roesel K, Sokolova Y, Snowden KF, Solter L. Microsporidia - Emergent Pathogens in the Global Food Chain. Trends Parasitol. 2016 Apr; 32(4):336-348. PMID: 26796229.
      View in: PubMed
    14. Reinke AW, Troemel E. The Development of Genetic Modification Techniques in Intracellular Parasites and Potential Applications to Microsporidia. PLoS Pathog. 2015 Dec; 11(12):e1005283. PMID: 26720003; PMCID: PMC4699923.
    15. Troemel E, Becnel JJ. Genome analysis and polar tube firing dynamics of mosquito-infecting microsporidia. Fungal Genet Biol. 2015 Oct; 83:41-44. PMID: 26300319; PMCID: PMC4587305 [Available on 10/01/16].
    16. Szumowski SC, Estes KA, Popovich JJ, Botts MR, Sek G, Troemel E. Small GTPases promote actin coat formation on microsporidian pathogens traversing the apical membrane of Caenorhabditis elegans intestinal cells. Cell Microbiol. 2016 Jan; 18(1):30-45. PMID: 26147591.
      View in: PubMed
    17. Luallen RJ, Bakowski MA, Troemel E. Characterization of microsporidia-induced developmental arrest and a transmembrane leucine-rich repeat protein in Caenorhabditis elegans. PLoS One. 2015; 10(4):e0124065. PMID: 25874557; PMCID: PMC4395247.
    18. Szumowski SC, Troemel E. Microsporidia-host interactions. Curr Opin Microbiol. 2015 Aug; 26:10-6. PMID: 25847674; PMCID: PMC4577307.
    19. Lin AE, Beasley FC, Keller N, Hollands A, Urbano R, Troemel E, Hoffman HM, Nizet V. A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1ß-dependent macrophage immune response. MBio. 2015 Mar 10; 6(2):e00133. PMID: 25759502; PMCID: PMC4453525.
    20. Balla KM, Andersen EC, Kruglyak L, Troemel E. A wild C. elegans strain has enhanced epithelial immunity to a natural microsporidian parasite. PLoS Pathog. 2015 Feb; 11(2):e1004583. PMID: 25680197; PMCID: PMC4334554.
    21. Cohen LB, Troemel E. Microbial pathogenesis and host defense in the nematode C. elegans. Curr Opin Microbiol. 2015 Feb; 23:94-101. PMID: 25461579; PMCID: PMC4324121.
    22. Bakowski MA, Priest M, Young S, Cuomo CA, Troemel E. Genome Sequence of the Microsporidian Species Nematocida sp1 Strain ERTm6 (ATCC PRA-372). Genome Announc. 2014 Sep 18; 2(5). PMID: 25237020; PMCID: PMC4172269.
    23. Luallen RJ, Troemel E. Breaking barriers: a GPCR triggers immunity in nematodes. Nat Immunol. 2014 Sep; 15(9):826-8. PMID: 25137464.
      View in: PubMed
    24. Bakowski MA, Desjardins CA, Smelkinson MG, Dunbar TL, Dunbar TA, Lopez-Moyado IF, Rifkin SA, Cuomo CA, Troemel E. Ubiquitin-mediated response to microsporidia and virus infection in C. elegans. PLoS Pathog. 2014 Jun; 10(6):e1004200. PMID: 24945527; PMCID: PMC4063957.
    25. Szumowski SC, Botts MR, Popovich JJ, Smelkinson MG, Troemel E. The small GTPase RAB-11 directs polarized exocytosis of the intracellular pathogen N. parisii for fecal-oral transmission from C. elegans. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8215-20. PMID: 24843160; PMCID: PMC4050618.
    26. Troemel E, Valdivia RH. Cell biology at the host-microbe interface. Mol Biol Cell. 2014 Mar; 25(6):729. PMID: 24626843; PMCID: PMC3952837.
    27. Balla KM, Troemel E. Caenorhabditis elegans as a model for intracellular pathogen infection. Cell Microbiol. 2013 Aug; 15(8):1313-22. PMID: 23617769; PMCID: PMC3894601.
    28. Troemel E. Host detection of pathogen-induced translational inhibition: a new pathogen-specific branch of the innate immune system? Future Microbiol. 2012 Oct; 7(10):1133-6. PMID: 23030419; PMCID: PMC3898340.
    29. Szumowski SC, Estes KA, Troemel E. Preparing a discreet escape: Microsporidia reorganize host cytoskeleton prior to non-lytic exit from C. elegans intestinal cells. Worm. 2012 Oct 01; 1(4):207-11. PMID: 24058850; PMCID: PMC3670220.
    30. Cuomo CA, Desjardins CA, Bakowski MA, Goldberg J, Ma AT, Becnel JJ, Didier ES, Fan L, Heiman DI, Levin JZ, Young S, Zeng Q, Troemel E. Microsporidian genome analysis reveals evolutionary strategies for obligate intracellular growth. Genome Res. 2012 Dec; 22(12):2478-88. PMID: 22813931; PMCID: PMC3514677.
    31. Dunbar TL, Yan Z, Balla KM, Smelkinson MG, Troemel E. C. elegans detects pathogen-induced translational inhibition to activate immune signaling. Cell Host Microbe. 2012 Apr 19; 11(4):375-86. PMID: 22520465; PMCID: PMC3334869.
    32. Estes KA, Szumowski SC, Troemel E. Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells. PLoS Pathog. 2011 Sep; 7(9):e1002227. PMID: 21949650; PMCID: PMC3174248.
    33. Troemel E. New models of microsporidiosis: infections in Zebrafish, C. elegans, and honey bee. PLoS Pathog. 2011 Feb; 7(2):e1001243. PMID: 21379567; PMCID: PMC3040677.
    34. Irazoqui JE, Troemel E, Feinbaum RL, Luhachack LG, Cezairliyan BO, Ausubel FM. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathog. 2010 Jul 01; 6:e1000982. PMID: 20617181; PMCID: PMC2895663.
    35. Estes KA, Dunbar TL, Powell JR, Ausubel FM, Troemel E. bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):2153-8. PMID: 20133860; PMCID: PMC2836710.
    36. Troemel E, Félix MA, Whiteman NK, Barrière A, Ausubel FM. Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans. PLoS Biol. 2008 Dec 09; 6(12):2736-52. PMID: 19071962.
      View in: PubMed
    37. Miyata S, Begun J, Troemel E, Ausubel FM. DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics. 2008 Feb; 178(2):903-18. PMID: 18245330; PMCID: PMC2248360.
    38. Troemel E, Chu SW, Reinke V, Lee SS, Ausubel FM, Kim DH. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2006 Nov 10; 2(11):e183. PMID: 17096597; PMCID: PMC1635533.
    39. Peckol EL, Troemel E, Bargmann CI. Sensory experience and sensory activity regulate chemosensory receptor gene expression in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11032-8. PMID: 11572964; PMCID: PMC58678.
    40. Troemel E. Chemosensory signaling in C. elegans. Bioessays. 1999 Dec; 21(12):1011-20. PMID: 10580986.
      View in: PubMed
    41. Troemel E, Sagasti A, Bargmann CI. Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans. Cell. 1999 Nov 12; 99(4):387-98. PMID: 10571181.
      View in: PubMed
    42. Dwyer ND, Troemel E, Sengupta P, Bargmann CI. Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. Cell. 1998 May 01; 93(3):455-66. PMID: 9590179.
      View in: PubMed
    43. Troemel E, Kimmel BE, Bargmann CI. Reprogramming chemotaxis responses: sensory neurons define olfactory preferences in C. elegans. Cell. 1997 Oct 17; 91(2):161-9. PMID: 9346234.
      View in: PubMed
    44. Chou JH, Troemel E, Sengupta P, Colbert HA, Tong L, Tobin DM, Roayaie K, Crump JG, Dwyer ND, Bargmann CI. Olfactory recognition and discrimination in Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol. 1996; 61:157-64. PMID: 9246444.
      View in: PubMed
    45. Troemel E, Chou JH, Dwyer ND, Colbert HA, Bargmann CI. Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans. Cell. 1995 Oct 20; 83(2):207-18. PMID: 7585938.
      View in: PubMed
    46. Kimble J, Crittenden S, Lambie E, Kodoyianni V, Mango S, Troemel E. Regulation of induction by GLP1, and localized cell surface receptor in Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol. 1992; 57:401-7. PMID: 1339675.
      View in: PubMed