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Gary Firestein

Title(s)Distinguished Professor, Medicine
SchoolHealth Sciences
Phone858-822-0591
ORCID ORCID Icon0000-0003-3495-960X Additional info
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    Other Positions
    Title(s)Dean and Associate Vice Chancellor for Clinical and Translational Research

    Title(s)Director, Clinical and Translational Research Institute (CTRI)


    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins UniversityMDSchool of Medicine
    Harvard CollegeAB
    Collapse Awards and Honors
    University of Glasgow2019Doctor of Science (h.c.)
    Arthritis Foundation2016 Lee C. Howley Sr Prize for Arthritis Research
    Johns Hopkins Alumni Association2012Distinguished Alumnus Award
    Arthritis Foundation2010Jane Wyman Humanitarian Award
    American College of Rheumatology2009Distinguished Investigator Award
    Arthritis Foundation2006Lee C. Howley Sr Prize for Arthritis Research
    Wiesbaden, Germany1998Carol-Nachman Prize

    Collapse Overview 
    Collapse Overview
    Gary S. Firestein, MD is Director of the Clinical and Translational Research Institute and the Dean and Associate Vice Chancellor of Translational Medicine at UC San Diego. Dr. Firestein joined the faculty at UCSD School of Medicine as Assistant Professor of Medicine in 1988. Four years later, he was recruited by Gensia, Inc. to be Director of Immunology where he supervised drug discovery efforts focusing on the potential role of purines in inflammation. In 1996, he returned to UCSD where he served as chief of the Division of Rheumatology, Allergy and Immunology from 1998 until 2010.

    Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis. He was among the first to map the cytokine profile of RA and demonstrate the dominance of macrophage and fibroblast products. These studies played a pivotal role in the development of highly effective anti-TNF and other anti-cytokine therapies for RA. More recently, he helped define the role of signal transduction and epigenetics in RA. In 1998, Dr. Firestein received the Carol-Nachman Prize, which is an international award given for outstanding contributions to rheumatology research. In 2006 and 2009, he received the Arthritis Foundation Lee C. Howley Sr Prize for Arthritis Research and the American College of Rheumatology Distinguished Investigator Award, respectively. Dr. Firestein received the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for contributions to rheumatology. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. In 2019, he received an honorary Doctor of Science degree from the University of Glasgow.

    Dr. Firestein has written over 350 articles and chapters and has edited or written several books. He served as the Deputy Editor of Arthritis & Rheumatism and is currently the Editor-in-Chief of the Kelley and Firestein’s Textbook of Rheumatology. He was chairperson of the FDA Arthritis Advisory Committee and has served on the ACR Committee on Research, the ACR Committee on Journal Publications, the ACR Committee on Nominations, the Arthritis Foundation Research Committee, NIAMS Advisory Council and the Board of Directors of the Veteran's Medical Research Foundation, ACR Rheumatology Research Foundation, and the American College of Rheumatology.

    Collapse Research 
    Collapse Research Activities and Funding
    Joint-location specific pathogenic pathways in rheumatoid arthritis
    NIH/NIAMS R01AR071321Jul 1, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Identifying synergistic therapeutic targets in RA using systems biology
    NIH/NIAMS R21AR070310Sep 15, 2016 - Jun 30, 2018
    Role: Principal Investigator
    UC San Diego Clinical and Translational Research Institute
    NIH/NCATS UL1TR001442Aug 13, 2015 - Mar 31, 2020
    Role: Principal Investigator
    High resolution DNA methylation signature in rheumatoid arthritis
    NIH/NIAMS R01AR065466Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Regulation of p38 and inflammation by MAPK kinases
    NIH/NIAID R01AI070555Jul 1, 2010 - Mar 31, 2017
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH/NCATS UL1TR000100Jul 1, 2010 - Sep 30, 2015
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH/NCRR KL2RR031978Jul 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH/NCATS KL2TR000099Jul 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH/NCRR TL1RR031979Jul 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH/NCATS TL1TR000098Jul 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH/NCRR UL1RR031980Jul 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    Innate immunity and the IKKi complex in Rheumatoid Arthritis (RA) synovium
    NIH/NIAID R01AI067752Feb 1, 2007 - Jan 31, 2013
    Role: Principal Investigator
    IKKi expression and regulation in rheumatoid arthritis
    NIH/NIAID R03AI058954Apr 1, 2004 - Mar 31, 2006
    Role: Principal Investigator
    c-Jun N-terminal kinase and joint destruction in RA
    NIH/NIAMS R55AR047825Sep 30, 2001 - Jun 14, 2002
    Role: Principal Investigator
    RHEUMATIC DISEASES CORE CENTER
    NIH/NIAMS P30AR047360Sep 28, 2001 - Mar 31, 2008
    Role: Co-Investigator
    c-Jun N-terminal kinase and joint destruction in RA
    NIH/NIAMS R01AR047825Jul 1, 2001 - May 31, 2008
    Role: Principal Investigator
    Training grant in Rheumatic Diseases
    NIH/NIAMS T32AR007608Apr 1, 2000 - Apr 30, 2012
    Role: Principal Investigator
    REGULATION OF PERIPHERAL INFLAMMATION BY THE CNS
    NIH/NIAMS R01AR045282Jan 15, 1999 - Nov 30, 2003
    Role: Principal Investigator
    MOLECULAR THERAPEUTICS OF RHEUMATOID ARTHRITIS
    NIH/NIAMS P50AR044850Sep 28, 1998 - Aug 31, 2004
    Role: Co-Investigator
    CONFERENCE ON PATHOGENESIS OF RHEUMATOID ARTHRITIS
    NIH/NIAMS R13AR045165Jan 1, 1998 - Dec 31, 1998
    Role: Principal Investigator
    Synovial dysfunction due to p53 abnormalities in RA
    NIH/NIAMS R01AR045347Sep 30, 1997 - May 14, 2002
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Jan 27, 1997 - Nov 30, 2010
    Role: Co-Investigator
    APOPTOSIS IN RHEUMATOID ARTHRITIS
    NIH/NIAMS R01AR043892Sep 30, 1996 - Sep 29, 1998
    Role: Principal Investigator
    MULTIPURPOSE ARTHRITIS &MUSCULOSKELETAL DISEASE CENTER
    NIH/NIAMS P60AR040770Aug 1, 1991 - Mar 6, 1997
    Role: Co-Investigator
    CYTOKINE INTERACTIONS IN INFLAMMATORY ARTHRITIS
    NIH/NIAMS R01AR040525Aug 31, 1990 - Jun 30, 1996
    Role: Principal Investigator
    LYMPHOKINES IN RHEUMATOID ARTHRITIS
    NIH/NIAMS R29AR039576Jul 1, 1988 - Mar 2, 1992
    Role: Principal Investigator
    IMMUNOREACTANTS IN RHEUMATIC DISEASES
    NIH/NIAMS R01AR014916May 1, 1976 - Dec 31, 1990
    Role: Principal Investigator
    IMMUNOREACTANTS IN RHEUMATIC DISEASES
    NIH/NIADDK R01AM014916May 1, 1976 - Dec 31, 1989
    Role: Principal Investigator
    RHEUMATIC DISEASES
    NIH/NIAMS T32AR007062Jul 1, 1975 - Sep 30, 1998
    Role: Principal Investigator
    RHEUMATIC DISEASES
    NIH/NIADDK T32AM007062Jul 1, 1975 - Jun 30, 1990
    Role: Principal Investigator

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