Gary Firestein

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-3495-960X Additional info
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    Other Positions
    Title(s)Senior Associate Vice Chancellor for Health Sciences

    Title(s)Director, Clinical and Translational Research Institute (CTRI)


    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins UniversityMDSchool of Medicine
    Harvard CollegeAB
    Collapse Awards and Honors
    American Association for the Advancement of Science2022Elected Fellow
    University of Glasgow2019Doctor of Science (h.c.)
    Arthritis Foundation2016 Lee C. Howley Sr Prize for Arthritis Research
    Johns Hopkins Alumni Association2012Distinguished Alumnus Award
    Arthritis Foundation2010Jane Wyman Humanitarian Award
    American College of Rheumatology2009Distinguished Investigator Award
    Arthritis Foundation2006Lee C. Howley Sr Prize for Arthritis Research
    Wiesbaden, Germany1998Carol-Nachman Prize

    Collapse Overview 
    Collapse Overview
    Gary S. Firestein, MD is Founding Director of the Clinical and Translational Research Institute and the Senior Associate Vice Chancellor of Health Sciences at UC San Diego. Dr. Firestein joined the faculty at UCSD School of Medicine as Assistant Professor of Medicine in 1988. Four years later, he was recruited by Gensia, Inc. to be Director of Immunology where he supervised drug discovery efforts focusing on the potential role of purines in inflammation. In 1996, he returned to UCSD where he served as chief of the Division of Rheumatology, Allergy and Immunology from 1998 until 2010.

    Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis. He was among the first to map the cytokine profile of RA and demonstrate the dominance of macrophage and fibroblast products. These studies played a pivotal role in the development of highly effective anti-TNF and other anti-cytokine therapies for RA. More recently, he helped define the role of signal transduction and epigenetics in RA. In 1998, Dr. Firestein received the Carol-Nachman Prize, which is an international award given for outstanding contributions to rheumatology research. In 2006 and 2009, he received the Arthritis Foundation Lee C. Howley Sr Prize for Arthritis Research and the American College of Rheumatology Distinguished Investigator Award, respectively. Dr. Firestein received the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for contributions to rheumatology. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. In 2019, he received an honorary Doctor of Science degree from the University of Glasgow.

    Dr. Firestein has written over 370 articles and chapters and has edited or written several books. He served as the Deputy Editor of Arthritis & Rheumatism and is the Editor-in-Chief of the Firestein and Kelley's Textbook of Rheumatology. He was chairperson of the FDA Arthritis Advisory Committee and has served on the ACR Committee on Research, the ACR Committee on Journal Publications, the ACR Committee on Nominations, the Arthritis Foundation Research Committee, NIAMS Advisory Council and the Board of Directors of the Veteran's Medical Research Foundation, ACR Rheumatology Research Foundation, and the American College of Rheumatology.

    Collapse Research 
    Collapse Research Activities and Funding
    Pathogenic role of ILC2 in rheumatoid arthritis
    NIH R21AR076578Sep 24, 2020 - Aug 31, 2022
    Role: Principal Investigator
    Joint-location specific pathogenic pathways in rheumatoid arthritis
    NIH R01AR071321Jul 1, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Identifying synergistic therapeutic targets in RA using systems biology
    NIH R21AR070310Sep 15, 2016 - Jun 30, 2019
    Role: Principal Investigator
    UC San Diego Clinical and Translational Research Institute
    NIH UL1TR001442Aug 13, 2015 - Apr 30, 2025
    Role: Principal Investigator
    Identification of key regulators in rheumatoid arthritis
    NIH R01AR065466Aug 1, 2014 - Apr 30, 2025
    Role: Principal Investigator
    Regulation of the type I interferon response by IRFs in inflammatory arthritis
    NIH R01AR059129Apr 1, 2011 - Mar 31, 2018
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH UL1TR000100Jul 1, 2010 - Mar 31, 2016
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH KL2TR000099Jul 1, 2010 - Jun 30, 2015
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH TL1TR000098Jul 1, 2010 - Jun 30, 2015
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH KL2RR031978Jul 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH TL1RR031979Jul 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    San Diego Clinical and Translational Research Institute
    NIH UL1RR031980Jul 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    Innate immunity and the IKKi complex in Rheumatoid Arthritis (RA) synovium
    NIH R01AI067752Feb 1, 2007 - Jan 31, 2013
    Role: Principal Investigator
    Regulation of p38 and inflammation by MAPK kinases
    NIH R01AI070555May 15, 2006 - Mar 31, 2018
    Role: Principal Investigator
    IKKi expression and regulation in rheumatoid arthritis
    NIH R03AI058954Apr 1, 2004 - Mar 31, 2006
    Role: Principal Investigator
    c-Jun N-terminal kinase and joint destruction in RA
    NIH R55AR047825Sep 30, 2001 - Jun 14, 2002
    Role: Principal Investigator
    RHEUMATIC DISEASES CORE CENTER
    NIH P30AR047360Sep 28, 2001 - Mar 31, 2008
    Role: Co-Investigator
    c-Jun N-terminal kinase and joint destruction in RA
    NIH R01AR047825Jul 1, 2001 - Aug 31, 2014
    Role: Principal Investigator
    Training grant in Rheumatic Diseases
    NIH T32AR007608Apr 1, 2000 - Apr 30, 2012
    Role: Principal Investigator
    REGULATION OF PERIPHERAL INFLAMMATION BY THE CNS
    NIH R01AR045282Jan 15, 1999 - Nov 30, 2003
    Role: Principal Investigator
    MOLECULAR THERAPEUTICS OF RHEUMATOID ARTHRITIS
    NIH/NIAMS P50AR044850Sep 28, 1998 - Aug 31, 2004
    Role: Co-Investigator
    CONFERENCE ON PATHOGENESIS OF RHEUMATOID ARTHRITIS
    NIH R13AR045165Jan 1, 1998 - Dec 31, 1998
    Role: Principal Investigator
    Synovial dysfunction due to p53 abnormalities in RA
    NIH R01AR045347Sep 30, 1997 - Apr 30, 2008
    Role: Principal Investigator
    APOPTOSIS IN RHEUMATOID ARTHRITIS
    NIH R01AR043892Sep 30, 1996 - Sep 29, 1998
    Role: Principal Investigator
    MULTIPURPOSE ARTHRITIS &MUSCULOSKELETAL DISEASE CENTER
    NIH P60AR040770Aug 1, 1991 - Feb 28, 2002
    Role: Co-Investigator
    CYTOKINE INTERACTIONS IN INFLAMMATORY ARTHRITIS
    NIH R01AR040525Aug 31, 1990 - Jun 30, 1996
    Role: Principal Investigator
    LYMPHOKINES IN RHEUMATOID ARTHRITIS
    NIH R29AR039576Jul 1, 1988 - Jun 30, 1993
    Role: Principal Investigator
    IMMUNOREACTANTS IN RHEUMATIC DISEASES
    NIH R01AR014916May 1, 1976 - Dec 31, 1990
    Role: Principal Investigator
    IMMUNOREACTANTS IN RHEUMATIC DISEASES
    NIH R01AM014916May 1, 1976 - Dec 31, 1989
    Role: Principal Investigator
    RHEUMATIC DISEASES
    NIH T32AR007062Jul 1, 1975 - Sep 30, 1998
    Role: Principal Investigator
    RHEUMATIC DISEASES
    NIH T32AM007062Jul 1, 1975 - Jun 30, 1990
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium. Nat Commun. 2024 Jun 11; 15(1):4991. Dunlap G, Wagner A, Meednu N, Wang R, Zhang F, Ekabe JC, Jonsson AH, Wei K, Sakaue S, Nathan A, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (A, Bykerk VP, Donlin LT, Goodman SM, Firestein GS, Boyle DL, Holers VM, Moreland LW, Tabechian D, Pitzalis C, Filer A, Raychaudhuri S, Brenner MB, Thakar J, McDavid A, Rao DA, Anolik JH. PMID: 38862501; PMCID: PMC11167034.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Dysregulated NUB1 and Neddylation Enhances Rheumatoid Arthritis Fibroblast-Like Synoviocyte Inflammatory Responses. Arthritis Rheumatol. 2024 Aug; 76(8):1252-1262. Sendo S, Machado CRL, Boyle DL, Benschop RJ, Perumal NB, Choi E, Wang W, Firestein GS. PMID: 38566346.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Joint-specific regulation of homeobox D10 expression in rheumatoid arthritis fibroblast-like synoviocytes. PLoS One. 2024; 19(6):e0304530. Lee H, Machado CRL, Hammaker D, Choi E, Prideaux EB, Wang W, Boyle DL, Firestein GS. PMID: 38829908; PMCID: PMC11146700.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Joint-specific rheumatoid arthritis fibroblast-like synoviocyte regulation identified by integration of chromatin access and transcriptional activity. JCI Insight. 2024 May 23; 9(12). Choi E, Machado CR, Okano T, Boyle D, Wang W, Firestein GS. PMID: 38781031.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Laser Capture Microscopy RNA Sequencing for Topological Mapping of Synovial Pathology During Rheumatoid Arthritis. Arthritis Rheumatol. 2024 Aug; 76(8):1243-1251. Van Espen B, Prideaux EB, Wilson AR, Machado CRL, Sendo S, Parker J, Seumois G, Sacchetti C, Belongia AC, Perumal NB, Vijayanand P, Linnik MD, Benschop RJ, Wang W, Bottini N, Firestein GS, Stanford SM. PMID: 38556917.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. What Is Rheumatoid Arthritis? N Engl J Med. 2024 Apr 04; 390(13):e32. Gravallese EM, Firestein GS, Koscal N, Ling E, Longo DL, Messenger LA, Schubach A. PMID: 38598569.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Cytokine and T cell responses in post-chikungunya viral arthritis: A cross-sectional study. PLoS One. 2024; 19(3):e0299521. Chang AY, Tritsch SR, Herrera Gomez CA, Encinales L, Cadena Bonfanti A, Rosales W, Mendoza-Torres E, Simmens S, Amdur RL, Mores CN, Fierbaugh P, Perez Hernandez CA, Avendaño G, Silvera PB, Crespo YG, Jimenez ADC, Martinez Zapata JC, Jimenez D, Osorio-Llanes E, Castellar-Lopez J, Suchowiecki K, Martins K, Gregory M, Zuluaga I, Proctor A, Hernández AS, Sierra-Carrero L, Colpas MV, Hernandez JCP, Quast AAF, De Barros JAC, Mejía JF, Ruiz JP, Boyle D, Firestein GS, Simon GL. PMID: 38507338; PMCID: PMC10954186.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Joint-specific rheumatoid arthritis fibroblast-like synoviocyte regulation identified by integration of chromatin access and transcriptional activity. bioRxiv. 2024 Jan 23. Choi E, Machado CRL, Okano T, Boyle D, Wang W, Firestein GS. PMID: 38293079; PMCID: PMC10827126.
      View in: PubMed   Mentions:
    9. The core functions and forms paradigm throughout EPIS: designing and implementing an evidence-based practice with function fidelity. Front Health Serv. 2023; 3:1281690. Terrana A, Viglione C, Rhee K, Rabin B, Godino J, Aarons GA, Chapman J, Melendrez B, Holguin M, Osorio L, Gidwani P, Juarez Nunez C, Firestein G, Hekler E. PMID: 38292916; PMCID: PMC10826509.
      View in: PubMed   Mentions:
    10. The Natural History of Post-Chikungunya Viral Arthritis Disease Activity and T-cell Immunology: A Cohort Study. J Cell Immunol. 2024; 6(2):64-75. Chang AY, Hernández AS, Mejía JF, Tritsch SR, Mendoza-Torres E, Encinales L, Bonfanti AC, Proctor AM, Simon GL, Simmens SJ, Firestein GS. PMID: 38873035; PMCID: PMC11172407.
      View in: PubMed   Mentions:
    11. Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis. Nat Commun. 2023 Nov 22; 14(1):7637. James EA, Holers VM, Iyer R, Prideaux EB, Rao NL, Rims C, Muir VS, Posso SE, Bloom MS, Zia A, Elliott SE, Adamska JZ, Ai R, Brewer RC, Seifert JA, Moss L, Barzideh S, Demoruelle MK, Striebich CC, Okamoto Y, Sainbayar E, Crook AA, Peterson RA, Vanderlinden LA, Wang W, Boyle DL, Robinson WH, Buckner JH, Firestein GS, Deane KD. PMID: 37993439; PMCID: PMC10665556.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. Nature. 2023 Nov; 623(7987):616-624. Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q, Gutierrez-Arcelus M, Apruzzese W, Watts GFM, Weisenfeld D, Nayar S, Rangel-Moreno J, Meednu N, Marks KE, Mantel I, Kang JB, Rumker L, Mears J, Slowikowski K, Weinand K, Orange DE, Geraldino-Pardilla L, Deane KD, Tabechian D, Ceponis A, Firestein GS, Maybury M, Sahbudin I, Ben-Artzi A, Mandelin AM, Nerviani A, Lewis MJ, Rivellese F, Pitzalis C, Hughes LB, Horowitz D, DiCarlo E, Gravallese EM, Boyce BF, Accelerating Medicines Partnership: RA/SLE Network, Moreland LW, Goodman SM, Perlman H, Holers VM, Liao KP, Filer A, Bykerk VP, Wei K, Rao DA, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S. PMID: 37938773; PMCID: PMC10651487.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    13. Serum reactivity to citrullinated protein/peptide antigens and left ventricular structure and function in the Multi-Ethnic Study of Atherosclerosis (MESA). PLoS One. 2023; 18(10):e0291967. Hughes-Austin JM, Katz R, Majka DS, Criqui MH, Robinson WH, Firestein GS, Hundley WG, Ix JH. PMID: 37874814; PMCID: PMC10597499.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Fibroblast multiplicity in RA: a synovial state of affairs. Nat Rev Rheumatol. 2023 10; 19(10):609-610. Machado CRL, Firestein GS. PMID: 37605002.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. The Evolve to Next-Gen ACT Network: An evolving open-access, real-world data resource primed for real-world evidence research across the Clinical and Translational Science Award Consortium. J Clin Transl Sci. 2023; 7(1):e224. Morrato EH, Lennox LA, Dearing JW, Coughlan AT, Gano ES, McFadden D, Mora N, Pincus HA, Firestein GS, Toto R, Reis SE. PMID: 38028333; PMCID: PMC10643916.
      View in: PubMed   Mentions: 1  
    16. Cost-effectiveness of social media advertising as a recruitment tool: A systematic review and meta-analysis. J Clin Transl Sci. 2023; 7(1):e180. Tsaltskan V, Sanchez Baez R, Firestein GS. PMID: 37745929; PMCID: PMC10514690.
      View in: PubMed   Mentions:
    17. Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis. bioRxiv. 2023 Jul 04. Inamo J, Keegan J, Griffith A, Ghosh T, Horisberger A, Howard K, Pulford J, Murzin E, Hancock B, Jonsson AH, Seifert J, Feser ML, Norris JM, Cao Y, Apruzzese W, Louis Bridges S, Bykerk V, Goodman S, Donlin L, Firestein GS, Perlman H, Bathon JM, Hughes LB, Tabechian D, Filer A, Pitzalis C, Anolik JH, Moreland L, Guthridge JM, James JA, Brenner MB, Raychaudhuri S, Sparks JA, Accelerating Medicines Partnership RA/SLE Network, Michael Holers V, Deane KD, Lederer JA, Rao DA, Zhang F. PMID: 37461737; PMCID: PMC10349983.
      View in: PubMed   Mentions: 1  
    18. Rheumatoid Arthritis. Reply. N Engl J Med. 2023 May 18; 388(20):1919-1920. Gravallese EM, Firestein GS. PMID: 37195963.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium. bioRxiv. 2023 Mar 21. Dunlap G, Wagner A, Meednu N, Zhang F, Jonsson AH, Wei K, Sakaue S, Nathan A, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (A, Bykerk VP, Donlin LT, Goodman SM, Firestein GS, Boyle DL, Holers VM, Moreland LW, Tabechian D, Pitzalis C, Filer A, Raychaudhuri S, Brenner MB, McDavid A, Rao DA, Anolik JH. PMID: 36993527; PMCID: PMC10055242.
      View in: PubMed   Mentions:
    20. Rheumatoid Arthritis - Common Origins, Divergent Mechanisms. N Engl J Med. 2023 02 09; 388(6):529-542. Gravallese EM, Firestein GS. PMID: 36780677.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    21. The pathogenesis of rheumatoid arthritis. Immunity. 2022 12 13; 55(12):2255-2270. Alivernini S, Firestein GS, McInnes IB. PMID: 36516818.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    22. Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function. Nat Commun. 2022 10 20; 13(1):6221. Ainsworth RI, Hammaker D, Nygaard G, Ansalone C, Machado C, Zhang K, Zheng L, Carrillo L, Wildberg A, Kuhs A, Svensson MND, Boyle DL, Firestein GS, Wang W. PMID: 36266270; PMCID: PMC9584907.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. Targeting fibroblast-like synoviocytes in rheumatoid arthritis. Curr Opin Pharmacol. 2022 12; 67:102304. Tsaltskan V, Firestein GS. PMID: 36228471; PMCID: PMC9942784.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    24. Regulatory T-cells and GARP expression are decreased in exercise-associated chikungunya viral arthritis flares. Front Immunol. 2022; 13:1007106. Dobbs JE, Tritsch SR, Encinales L, Cadena A, Suchowiecki K, Simon G, Mores C, Insignares S, Orozco VPV, Ospino M, Echavez LA, Gomez CAH, Crespo YG, Amdur R, Jimenez ADC, Hernandez CAP, Zapata JCM, Hernandez AS, Silvera PB, Rosales W, Mendoza E, Osorio-Llanes E, Castellar J, Jimenez D, Cooper DM, Firestein GS, Martins K, Chang AY. PMID: 36275717; PMCID: PMC9585177.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. Editorial: Synovial tissue biopsy research. Front Med (Lausanne). 2022; 9:1004029. Veale DJ, Firestein GS, Wechalekar MD, Najm A. PMID: 36267626; PMCID: PMC9577487.
      View in: PubMed   Mentions:
    26. Improving Transcriptome Fidelity Following Synovial Tissue Disaggregation. Front Med (Lausanne). 2022; 9:919748. Boyle DL, Prideaux EB, Hillman J, Wang W, Firestein GS. PMID: 36035425; PMCID: PMC9400013.
      View in: PubMed   Mentions:
    27. Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries. Nat Genet. 2022 08; 54(8):1103-1116. Banday AR, Stanifer ML, Florez-Vargas O, Onabajo OO, Papenberg BW, Zahoor MA, Mirabello L, Ring TJ, Lee CH, Albert PS, Andreakos E, Arons E, Barsh G, Biesecker LG, Boyle DL, Brahier MS, Burnett-Hartman A, Carrington M, Chang E, Choe PG, Chisholm RL, Colli LM, Dalgard CL, Dude CM, Edberg J, Erdmann N, Feigelson HS, Fonseca BA, Firestein GS, Gehring AJ, Guo C, Ho M, Holland S, Hutchinson AA, Im H, Irby L, Ison MG, Joseph NT, Kim HB, Kreitman RJ, Korf BR, Lipkin SM, Mahgoub SM, Mohammed I, Paschoalini GL, Pacheco JA, Peluso MJ, Rader DJ, Redden DT, Ritchie MD, Rosenblum B, Ross ME, Anna HPS, Savage SA, Sharma S, Siouti E, Smith AK, Triantafyllia V, Vargas JM, Vargas JD, Verma A, Vij V, Wesemann DR, Yeager M, Yu X, Zhang Y, Boulant S, Chanock SJ, Feld JJ, Prokunina-Olsson L. PMID: 35835913; PMCID: PMC9355882.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    28. Mechanism-driven strategies for prevention of rheumatoid arthritis. Rheumatol Autoimmun. 2022 Sep; 2(3):109-119. Holers VM, Kuhn KA, Demoruelle MK, Norris JM, Firestein GS, James EA, Robinson WH, Buckner JH, Deane KD. PMID: 36312783; PMCID: PMC9610829.
      View in: PubMed   Mentions: 5  
    29. Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2022 07; 74(7):1159-1171. Torres A, Pedersen B, Cobo I, Ai R, Coras R, Murillo-Saich J, Nygaard G, Sanchez-Lopez E, Murphy A, Wang W, Firestein GS, Guma M. PMID: 35128827; PMCID: PMC9246826.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    30. Comparison of Web-Based Advertising and a Social Media Platform as Recruitment Tools for Underserved and Hard-to-Reach Populations in Rheumatology Clinical Research. ACR Open Rheumatol. 2022 Jul; 4(7):623-630. Tsaltskan V, Nguyen K, Eaglin C, Holers VM, Deane KD, Firestein GS. PMID: 35536990; PMCID: PMC9274346.
      View in: PubMed   Mentions: 4  
    31. Crosstalk between CD4 T cells and synovial fibroblasts from human arthritic joints promotes hyaluronan-dependent leukocyte adhesion and inflammatory cytokine expression in vitro. Matrix Biol Plus. 2022 Jun; 14:100110. Kang I, Hundhausen C, Evanko SP, Malapati P, Workman G, Chan CK, Rims C, Firestein GS, Boyle DL, MacDonald KM, Buckner JH, Wight TN. PMID: 35573706; PMCID: PMC9097711.
      View in: PubMed   Mentions: 2  
    32. A framework and road map for rapid start-up and completion of a COVID-19 vaccine trial: A single clinical trial site experience. J Clin Transl Sci. 2022; 6(1):e21. Rojas C, Spector SA, Cale B, Loughran M, Lazaro L, Mah E, Firestein GS, Gold KA, Wallace M. PMID: 35291217; PMCID: PMC8889226.
      View in: PubMed   Mentions:
    33. Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior. ACR Open Rheumatol. 2022 Apr; 4(4):288-299. Ansalone C, Ainsworth RI, Nygaard G, Ai R, Prideaux EB, Hammaker D, Perumal NB, Weichert K, Tung F, Kodandapani L, Sauder JM, Mertsching EC, Benschop RJ, Boyle DL, Wang W, Firestein GS. PMID: 34963199; PMCID: PMC8992463.
      View in: PubMed   Mentions: 3  
    34. Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis. Sci Rep. 2021 09 17; 11(1):18578. Watson H, Nogueira-Hayd RL, Rodrigues-Moreno M, Naveca F, Calusi G, Suchowiecki K, Firestein GS, Simon G, Chang AY. PMID: 34535727; PMCID: PMC8448837.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    35. Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19. medRxiv. 2021 Jul 13. Banday AR, Stanifer ML, Florez-Vargas O, Onabajo OO, Zahoor MA, Papenberg BW, Ring TJ, Lee CH, Andreakos E, Arons E, Barsh G, Biesecker LG, Boyle DL, Burnett-Hartman A, Carrington M, Chang E, Choe PG, Chrisholm RL, Dalgard C, Edberg J, Erdmann N, Feigelson HS, Firestein GS, Gehring AJ, Ho M, Holland S, Hutchinson AA, Im H, Ison MG, Kim HB, Kreitman RJ, Korf BR, Mirabello L, Pacheco JA, Peluso MJ, Rader DJ, Redden DT, Ritchie MD, Rosenbloom B, Sant Anna HP, Savage S, Siouti E, Triantafyllia V, Vargas JM, Verma A, Vij V, Wesemann DR, Yeager M, Yu X, Zhang Y, Boulant S, Chanock SJ, Feld JJ, Prokunina-Olsson L. PMID: 34282422; PMCID: PMC8288155.
      View in: PubMed   Mentions:
    36. Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis. Nat Commun. 2021 06 15; 12(1):3624. Beckmann D, Römer-Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, de Gorter DJJ, Dankbar B, Hillen J, Heitzmann M, Begemann I, Galic M, Weinhage T, Foell D, Ai R, Kremerskothen J, Kiener HP, Müller S, Kamradt T, Schröder C, Leitão E, Horsthemke B, Rosenstiel P, Nordström K, Gasparoni G, Gasparoni N, Walter J, Li N, Yang X, Chung HR, Pavenstädt H, Lindemann N, Schnittler HJ, Wang W, Firestein GS, Pap T, Korb-Pap A. PMID: 34131132; PMCID: PMC8206096.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    37. Development of a Coronavirus Disease 2019 (COVID-19) Application Ontology for the Accrual to Clinical Trials (ACT) network. JAMIA Open. 2021 Apr; 4(2):ooab036. Visweswaran S, Samayamuthu MJ, Morris M, Weber GM, MacFadden D, Trevvett P, Klann JG, Gainer VS, Benoit B, Murphy SN, Patel L, Mirkovic N, Borovskiy Y, Johnson RD, Wyatt MC, Wang AY, Follett RW, Chau N, Zhu W, Abajian M, Chuang A, Bahroos N, Reeder P, Xie D, Cai J, Sendro ER, Toto RD, Firestein GS, Nadler LM, Reis SE. PMID: 34113801; PMCID: PMC8083220.
      View in: PubMed   Mentions: 5  
    38. Development of a COVID-19 Application Ontology for the ACT Network. medRxiv. 2021 Apr 14. Visweswaran S, Samayamuthu MJ, Morris M, Weber GM, MacFadden D, Trevvett P, Klann JG, Gainer V, Benoit B, Murphy SN, Patel L, Mirkovic N, Borovskiy Y, Johnson RD, Wyatt MC, Wang AY, Follett RW, Chau N, Zhu W, Abajian M, Chuang A, Bahroos N, Reeder P, Xie D, Cai J, Sendro ER, Toto RD, Firestein GS, Nadler LM, Reis SE. PMID: 33791734; PMCID: PMC8010766.
      View in: PubMed   Mentions:
    39. Persistent Joint Pain Following Arthropod Virus Infections. Curr Rheumatol Rep. 2021 04 13; 23(4):26. Suchowiecki K, Reid SP, Simon GL, Firestein GS, Chang A. PMID: 33847834; PMCID: PMC8042844.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    40. IgG Epitopes Processed and Presented by IgG+ B Cells Induce Suppression by Human Thymic-Derived Regulatory T Cells. J Immunol. 2021 03 15; 206(6):1194-1203. Hsieh LE, Sidney J, Burns JC, Boyle DL, Firestein GS, Altman Y, Sette A, Franco A. PMID: 33579724; PMCID: PMC7939040.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    41. Distinct DNA Methylation Patterns of Rheumatoid Arthritis Peripheral Blood and Synovial Tissue T Cells. ACR Open Rheumatol. 2021 Mar; 3(3):127-132. Ai R, Boyle DL, Wang W, Firestein GS. PMID: 33544432; PMCID: PMC7966880.
      View in: PubMed   Mentions: 7  
    42. Building biorepositories in the midst of a pandemic. J Clin Transl Sci. 2021 Feb 05; 5(1):e92. Croker JA, Patel R, Campbell KS, Barton-Baxter M, Wallet S, Firestein GS, Kimberly RP, Elemento O. PMID: 34192049; PMCID: PMC8134891.
      View in: PubMed   Mentions: 8  
    43. Sleep Disturbances are a Significant Predictor of Chikungunya Arthritis Flare Severity. J Cell Immunol. 2021; 3(3):191-197. Tritsch SR, Amdur R, Encinales L, Cadena A, Fierbaugh P, Avendaño G, Gomez CAH, Suchowiecki K, Mendoza-Torres E, Rosales W, Jimenez D, Hernandez CAP, Hernandez AS, Silvera PB, Crespo YG, Jimenez ADC, Zapata JCM, Mores CN, Firestein GS, Simon G, Chang AY. PMID: 34322686; PMCID: PMC8315573.
      View in: PubMed   Mentions: 1  
    44. Scale-up of the Accrual to Clinical Trials (ACT) network across the Clinical and Translational Science Award Consortium: a mixed-methods evaluation of the first 18 months. J Clin Transl Sci. 2020 Jun 30; 4(6):515-528. Morrato EH, Lennox LA, Sendro ER, Schuster AL, Pincus HA, Humensky J, Firestein GS, Nadler LM, Toto R, Reis SE. PMID: 33948228; PMCID: PMC8057421.
      View in: PubMed   Mentions: 4  
    45. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020 06; 6(26):eaba4353. Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N. PMID: 32637608; PMCID: PMC7319753.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    46. Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nat Rev Rheumatol. 2020 06; 16(6):316-333. Nygaard G, Firestein GS. PMID: 32393826; PMCID: PMC7987137.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansCells
    47. In Memoriam: William Phelps Arend, MD, 1937-2020. Arthritis Rheumatol. 2020 06; 72(6):866-867. Michael Holers V, Firestein GS, Deane KD. PMID: 32182399.
      View in: PubMed   Mentions:    Fields:    
    48. Persistent chikungunya arthritis in Roraima, Brazil. Clin Rheumatol. 2020 Sep; 39(9):2781-2787. Hayd RLN, Moreno MR, Naveca F, Amdur R, Suchowiecki K, Watson H, Firestein GS, Simon G, Chang AY. PMID: 32170487.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    49. Joint Location-Specific JAK-STAT Signaling in Rheumatoid Arthritis Fibroblast-like Synoviocytes. ACR Open Rheumatol. 2019 Dec; 1(10):640-648. Hammaker D, Nygaard G, Kuhs A, Ai R, Boyle DL, Wang W, Firestein GS. PMID: 31872186; PMCID: PMC6917316.
      View in: PubMed   Mentions: 13  
    50. Chronic Joint Pain 3 Years after Chikungunya Virus Infection Largely Characterized by Relapsing-remitting Symptoms. J Rheumatol. 2020 08 01; 47(8):1267-1274. Tritsch SR, Encinales L, Pacheco N, Cadena A, Cure C, McMahon E, Watson H, Porras Ramirez A, Mendoza AR, Li G, Khurana K, Jaller-Raad JJ, Castillo SM, Barrios Taborda O, Jaller-Char A, Echavez LA, Jiménez D, Gonzalez Coba A, Alarcon Gomez M, Ariza Orozco D, Bravo E, Martinez V, Guerra B, Simon G, Firestein GS, Chang AY. PMID: 31263071; PMCID: PMC7938419.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    51. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat Immunol. 2019 07; 20(7):928-942. Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE, Boyce BF, DiCarlo E, Gravallese EM, Gregersen PK, Moreland L, Firestein GS, Hacohen N, Nusbaum C, Lederer JA, Perlman H, Pitzalis C, Filer A, Holers VM, Bykerk VP, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S. PMID: 31061532; PMCID: PMC6602051.
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    52. PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes. Ann Rheum Dis. 2019 05; 78(5):600-609. Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, Meng TC, Liu L, Corr M, Stanford SM, Lewis M, Wang W, Firestein GS, Khew-Goodall Y, Pitzalis C, Bottini N. PMID: 30808624; PMCID: PMC7039277.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    53. Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study. Inflamm Res. 2019 Apr; 68(4):261-274. Boyle DL, DePrimo SE, Calderon C, Chen D, Dunford PJ, Barchuk W, Firestein GS, Thurmond RL. PMID: 30739130.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    54. The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection. Diseases. 2018 Oct 20; 6(4). Chang AY, Tritsch S, Reid SP, Martins K, Encinales L, Pacheco N, Amdur RL, Porras-Ramirez A, Rico-Mendoza A, Li G, Peng J, Firestein GS, Simon GL, Bethony JM. PMID: 30347791; PMCID: PMC6313749.
      View in: PubMed   Mentions: 11  
    55. Development of a game-based learning tool for applied team science communication in a virtual clinical trial. J Clin Transl Sci. 2018 Jun; 2(3):169-172. Depp CA, Howland A, Dumbauld J, Fontanesi J, Firestein D, Firestein GS. PMID: 30370069; PMCID: PMC6199551.
      View in: PubMed   Mentions: 2  
    56. Reply. Arthritis Rheumatol. 2018 11; 70(11):1893. Chang AY, Bethony JM, Simon GL, Reid SP, Encinales L, Firestein GS. PMID: 30003684; PMCID: PMC6203644.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. Reply. Arthritis Rheumatol. 2018 11; 70(11):1891-1892. Chang AY, Bethony JM, Simon GL, Encinales L, Firestein GS. PMID: 30003712; PMCID: PMC6203595.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    58. Accrual to Clinical Trials (ACT): A Clinical and Translational Science Award Consortium Network. JAMIA Open. 2018 Oct; 1(2):147-152. Visweswaran S, Becich MJ, D'Itri VS, Sendro ER, MacFadden D, Anderson NR, Allen KA, Ranganathan D, Murphy SN, Morrato EH, Pincus HA, Toto R, Firestein GS, Nadler LM, Reis SE. PMID: 30474072; PMCID: PMC6241502.
      View in: PubMed   Mentions: 55  
    59. Systems approach to assessing and improving local human research Institutional Review Board performance. J Clin Transl Sci. 2018 Apr; 2(2):103-109. Fontanesi J, Magit A, Ford JJ, Nguyen H, Firestein GS. PMID: 31660223; PMCID: PMC6799096.
      View in: PubMed   Mentions: 2  
    60. Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis. Ann Rheum Dis. 2018 11; 77(11):1636-1643. Bustamante MF, Oliveira PG, Garcia-Carbonell R, Croft AP, Smith JM, Serrano RL, Sanchez-Lopez E, Liu X, Kisseleva T, Hay N, Buckley CD, Firestein GS, Murphy AN, Miyamoto S, Guma M. PMID: 30061164; PMCID: PMC6328432.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    61. Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue Arthritis Res Ther. 2018 07 11; 20(1):139. Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A, Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH. PMID: 29996944; PMCID: PMC6042350.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    62. Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes. Nat Commun. 2018 05 15; 9(1):1921. Ai R, Laragione T, Hammaker D, Boyle DL, Wildberg A, Maeshima K, Palescandolo E, Krishna V, Pocalyko D, Whitaker JW, Bai Y, Nagpal S, Bachman KE, Ainsworth RI, Wang M, Ding B, Gulko PS, Wang W, Firestein GS. PMID: 29765031; PMCID: PMC5953939.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    63. Chikungunya Arthritis Mechanisms in the Americas: A Cross-Sectional Analysis of Chikungunya Arthritis Patients Twenty-Two Months After Infection Demonstrating No Detectable Viral Persistence in Synovial Fluid. Arthritis Rheumatol. 2018 04; 70(4):585-593. Chang AY, Martins KAO, Encinales L, Reid SP, Acuña M, Encinales C, Matranga CB, Pacheco N, Cure C, Shukla B, Ruiz Arteta T, Amdur R, Cazares LH, Gregory M, Ward MD, Porras A, Rico Mendoza A, Dong L, Kenny T, Brueggemann E, Downey LG, Kamalapathy P, Lichtenberger P, Falls O, Simon GL, Bethony JM, Firestein GS. PMID: 29266856; PMCID: PMC8127625.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    64. Frequency of Chronic Joint Pain Following Chikungunya Virus Infection: A Colombian Cohort Study. Arthritis Rheumatol. 2018 04; 70(4):578-584. Chang AY, Encinales L, Porras A, Pacheco N, Reid SP, Martins KAO, Pacheco S, Bravo E, Navarno M, Rico Mendoza A, Amdur R, Kamalapathy P, Firestein GS, Bethony JM, Simon GL. PMID: 29266783; PMCID: PMC7928267.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    65. Epigenetics of inflammatory arthritis. Curr Opin Rheumatol. 2018 03; 30(2):188-196. Hammaker D, Firestein GS. PMID: 29194108; PMCID: PMC5804499.
      View in: PubMed   Mentions: 38  Translation:HumansCells
    66. Rheumatoid arthritis. Nat Rev Dis Primers. 2018 02 08; 4:18001. Smolen JS, Aletaha D, Barton A, Burmester GR, Emery P, Firestein GS, Kavanaugh A, McInnes IB, Solomon DH, Strand V, Yamamoto K. PMID: 29417936.
      View in: PubMed   Mentions: 857     Fields:    Translation:HumansPHPublic Health
    67. Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis. Biochem Pharmacol. 2018 05; 151:282-290. Nygaard G, Di Paolo JA, Hammaker D, Boyle DL, Budas G, Notte GT, Mikaelian I, Barry V, Firestein GS. PMID: 29408488.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    68. PATHOGENESIS OF RHEUMATOID ARTHRITIS: THE INTERSECTION OF GENETICS AND EPIGENETICS. Trans Am Clin Climatol Assoc. 2018; 129:171-182. Firestein GS. PMID: 30166712; PMCID: PMC6116585.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    69. Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene. J Immunol. 2017 10 01; 199(7):2316-2322. Matsuda S, Hammaker D, Topolewski K, Briegel KJ, Boyle DL, Dowdy S, Wang W, Firestein GS. PMID: 28807995; PMCID: PMC5605444.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    70. PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints. Nat Commun. 2017 07 27; 8(1):146. Hong SS, Marotte H, Courbon G, Firestein GS, Boulanger P, Miossec P. PMID: 28747638; PMCID: PMC5529536.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    71. A multisite study of performance drivers among institutional review boards. J Clin Transl Sci. 2017 Jun; 1(3):192-197. Caligiuri M, Allen K, Buscher N, Denney L, Gates C, Kantelo K, Magit A, Sak R, Firestein GS, Fontanesi J. PMID: 29093967; PMCID: PMC5652635.
      View in: PubMed   Mentions: 5  
    72. Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis. Sci Rep. 2017 04 26; 7(1):1197. Kim KW, Kim BM, Lee KA, Lee SH, Firestein GS, Kim HR. PMID: 28446753; PMCID: PMC5430934.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    73. Epigenetics of the immune system and alterations in inflammation and autoimmunity. Epigenomics. 2017 04; 9(4):371-373. Tost J, Gay S, Firestein G. PMID: 28378617.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    74. Distinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast. Biomaterials. 2017 07; 133:119-131. Viger ML, Collet G, Lux J, Nguyen Huu VA, Guma M, Foucault-Collet A, Olejniczak J, Joshi-Barr S, Firestein GS, Almutairi A. PMID: 28433935; PMCID: PMC5704950.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    75. Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes. Epigenomics. 2017 04; 9(4):479-492. Doody KM, Bottini N, Firestein GS. PMID: 28322585; PMCID: PMC5549652.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    76. Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes. Arthritis Rheumatol. 2017 03; 69(3):550-559. Rhead B, Holingue C, Cole M, Shao X, Quach HL, Quach D, Shah K, Sinclair E, Graf J, Link T, Harrison R, Rahmani E, Halperin E, Wang W, Firestein GS, Barcellos LF, Criswell LA. PMID: 27723282; PMCID: PMC5328845.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    77. Immunopathogenesis of Rheumatoid Arthritis. Immunity. 2017 02 21; 46(2):183-196. Firestein GS, McInnes IB. PMID: 28228278; PMCID: PMC5385708.
      View in: PubMed   Mentions: 422     Fields:    Translation:HumansAnimals
    78. Cellular electrophysiological principles that modulate secretion from synovial fibroblasts. J Physiol. 2017 02 01; 595(3):635-645. Clark RB, Schmidt TA, Sachse FB, Boyle D, Firestein GS, Giles WR. PMID: 27079855; PMCID: PMC5285716.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    79. LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis. Arthritis Rheumatol. 2016 11; 68(11):2637-2645. Hammaker D, Whitaker JW, Maeshima K, Boyle DL, Ekwall AH, Wang W, Firestein GS. PMID: 27159840; PMCID: PMC5083131.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    80. Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes. Nat Commun. 2016 06 10; 7:11849. Ai R, Hammaker D, Boyle DL, Morgan R, Walsh AM, Fan S, Firestein GS, Wang W. PMID: 27282753; PMCID: PMC4906396.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    81. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight. 2016 May 19; 1(7). Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. PMID: 27275015; PMCID: PMC4889026.
      View in: PubMed   Mentions: 25     Fields:    
    82. Metabolomics in rheumatic diseases: desperately seeking biomarkers. Nat Rev Rheumatol. 2016 May; 12(5):269-81. Guma M, Tiziani S, Firestein GS. PMID: 26935283; PMCID: PMC4963238.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    83. Computationally expanding infinium HumanMethylation450 BeadChip array data to reveal distinct DNA methylation patterns of rheumatoid arthritis. Bioinformatics. 2016 06 15; 32(12):1773-8. Fan S, Li C, Ai R, Wang M, Firestein GS, Wang W. PMID: 26883487; PMCID: PMC4908326.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    84. Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice. Arthritis Rheumatol. 2016 Feb; 68(2):359-69. Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N. PMID: 26414708; PMCID: PMC4770259.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    85. Decade in review-translational rheumatology: Ten years after: rheumatology research from bench to bedside. Nat Rev Rheumatol. 2015 Nov; 11(11):623-4. Bottini N, Firestein GS. PMID: 26390844.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    86. Correction: Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets. PLoS One. 2015; 10(8):e0136334. Whitaker JW, Boyle DL, Bartok B, Ball ST, Gay S, Wang W, Firestein GS. PMID: 26288175; PMCID: PMC4544850.
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    87. DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis. Arthritis Rheumatol. 2015 Jul; 67(7):1978-80. Ai R, Whitaker JW, Boyle DL, Tak PP, Gerlag DM, Wang W, Firestein GS. PMID: 25808728; PMCID: PMC4485541.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    88. In appreciation of Joan M. Bathon, MD, Editor, Arthritis & Rheumatology, 2010-2015. Arthritis Rheumatol. 2015 Jun; 67(6):1411. Firestein GS, Diamond JS. PMID: 26010937.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    89. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci Transl Med. 2015 May 20; 7(288):288ra76. Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. PMID: 25995222; PMCID: PMC4458332.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    90. In memoriam: Nathan J. Zvaifler, MD, 1927-2015. Arthritis Rheumatol. 2015 May; 67(5):1143. Firestein GS, Corr M. PMID: 25917709.
      View in: PubMed   Mentions:    Fields:    
    91. The Rheumatoid Arthritis Risk Gene LBH Regulates Growth in Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2015 May; 67(5):1193-202. Ekwall AK, Whitaker JW, Hammaker D, Bugbee WD, Wang W, Firestein GS. PMID: 25707478; PMCID: PMC4490933.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    92. Integrative omics analysis of rheumatoid arthritis identifies non-obvious therapeutic targets. PLoS One. 2015; 10(4):e0124254. Whitaker JW, Boyle DL, Bartok B, Ball ST, Gay S, Wang W, Firestein GS. PMID: 25901943; PMCID: PMC4406750.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    93. Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor. J Pharmacol Exp Ther. 2015 Jun; 353(3):505-16. Schepetkin IA, Kirpotina LN, Hammaker D, Kochetkova I, Khlebnikov AI, Lyakhov SA, Firestein GS, Quinn MT. PMID: 25784649; PMCID: PMC4429673.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    94. Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Inflamm Bowel Dis. 2015 Feb; 21(2):323-30. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT. PMID: 25545378; PMCID: PMC4404151.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    95. The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis. Ann Rheum Dis. 2015 Jun; 74(6):1311-6. Boyle DL, Soma K, Hodge J, Kavanaugh A, Mandel D, Mease P, Shurmur R, Singhal AK, Wei N, Rosengren S, Kaplan I, Krishnaswami S, Luo Z, Bradley J, Firestein GS. PMID: 25398374; PMCID: PMC4431345.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCellsCTClinical Trials
    96. TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness. Ann Rheum Dis. 2016 Jan; 75(1):295-302. Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N. PMID: 25378349; PMCID: PMC4422771.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    97. Choline kinase inhibition in rheumatoid arthritis. Ann Rheum Dis. 2015 Jul; 74(7):1399-407. Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS. PMID: 25274633; PMCID: PMC4382461.
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    98. Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis. Aliment Pharmacol Ther. 2014 Sep; 40(5):477-85. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT. PMID: 25041724; PMCID: PMC4143528.
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    99. Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium. Arthritis Res Ther. 2014 Jun 12; 16(3):R121. Gong W, Kolker SJ, Usachev Y, Walder RY, Boyle DL, Firestein GS, Sluka KA. PMID: 24923411; PMCID: PMC4095605.
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    100. Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. J Inflamm (Lond). 2014; 11:14. Hammaker D, Boyle DL, Topolewski K, Firestein GS. PMID: 24855454; PMCID: PMC4030013.
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    101. Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain. Pain. 2014 Jun; 155(6):1150-1160. Leinders M, Koehrn FJ, Bartok B, Boyle DL, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin LS. PMID: 24631588; PMCID: PMC4128246.
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    102. Phosphoinositide 3-kinase δ regulates migration and invasion of synoviocytes in rheumatoid arthritis. J Immunol. 2014 Mar 01; 192(5):2063-70. Bartok B, Hammaker D, Firestein GS. PMID: 24470496.
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    103. Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss. PLoS One. 2014; 9(1):e84818. Boyle DL, Hammaker D, Edgar M, Zaiss MM, Teufel S, David JP, Schett G, Firestein GS. PMID: 24400116; PMCID: PMC3882259.
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    104. The disease formerly known as rheumatoid arthritis. Arthritis Res Ther. 2014; 16(3):114. Firestein GS. PMID: 25167330; PMCID: PMC4075245.
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    105. Novel phosphoinositide 3-kinase δ,γ inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis. J Pharmacol Exp Ther. 2014 Feb; 348(2):271-80. Boyle DL, Kim HR, Topolewski K, Bartok B, Firestein GS. PMID: 24244039.
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    106. Epigenetics in rheumatoid arthritis: a primer for rheumatologists. Curr Rheumatol Rep. 2013 Nov; 15(11):372. Bottini N, Firestein GS. PMID: 24072602.
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    107. Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis. Arthritis Rheum. 2013 May; 65(5):1194-202. Sluka KA, Rasmussen LA, Edgar MM, O'Donnell JM, Walder RY, Kolker SJ, Boyle DL, Firestein GS. PMID: 23335302; PMCID: PMC3636153.
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    108. Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. Arthritis Rheum. 2013 May; 65(5):1171-80. Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N. PMID: 23335101; PMCID: PMC3636201.
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    109. An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype. Genome Med. 2013; 5(4):40. Whitaker JW, Shoemaker R, Boyle DL, Hillman J, Anderson D, Wang W, Firestein GS. PMID: 23631487; PMCID: PMC3706831.
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    110. Regulation of DNA methylation in rheumatoid arthritis synoviocytes. J Immunol. 2013 Feb 01; 190(3):1297-303. Nakano K, Boyle DL, Firestein GS. PMID: 23277489; PMCID: PMC3552038.
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    111. The biophysical mechanisms of altered hyaluronan concentration in synovial fluid after anterior cruciate ligament transection. Arthritis Rheum. 2012 Dec; 64(12):3993-4003. McCarty WJ, Cheng JC, Hansen BC, Yamaguchi T, Firestein GS, Masuda K, Sah RL. PMID: 22933328; PMCID: PMC3510334.
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    112. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol. 2013 Jan; 9(1):24-33. Bottini N, Firestein GS. PMID: 23147896; PMCID: PMC3970924.
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    113. Clinical features of patients with anti-neutrophil cytoplasmic autoantibodies targeting native myeloperoxidase antigen. Mod Rheumatol. 2013 Sep; 23(5):963-71. Yamanishi Y, Ito-Ihara T, Nagao T, Uno K, Kobayashi S, Muso E, Shane PY, Firestein GS, Hashimoto H, Okazaki T, Suzuki K. PMID: 23085883.
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    114. c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. Open Rheumatol J. 2012; 6:220-31. Guma M, Firestein GS. PMID: 23028407; PMCID: PMC3460413.
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    115. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95. Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS. PMID: 22488549; PMCID: PMC3397277.
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    116. Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis. Nat Rev Rheumatol. 2012 Oct; 8(10):573-86. Arend WP, Firestein GS. PMID: 22907289.
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    117. [Intracellular signaling transduction pathways. Potential targets in the treatment of rheumatic diseases]. Z Rheumatol. 2012 Aug; 71(6):460-7. Frommer KW, Geyer M, Firestein GS. PMID: 22875571.
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    118. IgG4-related diseases. Best Pract Res Clin Rheumatol. 2012 Aug; 26(4):425-38. Guma M, Firestein GS. PMID: 23040358.
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    119. DNA methylome signature in rheumatoid arthritis. Ann Rheum Dis. 2013 Jan; 72(1):110-7. Nakano K, Whitaker JW, Boyle DL, Wang W, Firestein GS. PMID: 22736089; PMCID: PMC3549371.
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    120. Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS). Clin Transl Sci. 2012 Apr; 5(2):121-9. CTSA Principal Investigators, Shamoon H, Center D, Davis P, Tuchman M, Ginsberg H, Califf R, Stephens D, Mellman T, Verbalis J, Nadler L, Shekhar A, Ford D, Rizza R, Shaker R, Brady K, Murphy B, Cronstein B, Hochman J, Greenland P, Orwoll E, Sinoway L, Greenberg H, Jackson R, Coller B, Topol E, Guay-Woodford L, Runge M, Clark R, McClain D, Selker H, Lowery C, Dubinett S, Berglund L, Cooper D, Firestein G, Johnston SC, Solway J, Heubi J, Sokol R, Nelson D, Tobacman L, Rosenthal G, Aaronson L, Barohn R, Kern P, Sullivan J, Shanley T, Blazar B, Larson R, FitzGerald G, Reis S, Pearson T, Buchanan T, McPherson D, Brasier A, Toto R, Disis M, Drezner M, Bernard G, Clore J, Evanoff B, Imperato-McGinley J, Sherwin R, Pulley J. PMID: 22507116; PMCID: PMC3335735.
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    121. PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis. Am J Pathol. 2012 May; 180(5):1906-16. Bartok B, Boyle DL, Liu Y, Ren P, Ball ST, Bugbee WD, Rommel C, Firestein GS. PMID: 22433439.
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    122. Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice. Arthritis Rheum. 2012 Mar; 64(3):678-87. Hammaker D, Topolewski K, Edgar M, Yoshizawa T, Fukushima A, Boyle DL, Burak EC, Sah RL, Firestein GS. PMID: 21953132; PMCID: PMC3267851.
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    123. Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice. Orthop Clin North Am. 2012 Apr; 43(2):173-85, v. Chan EF, Harjanto R, Asahara H, Inoue N, Masuda K, Bugbee WD, Firestein GS, Hosalkar HS, Lotz MK, Sah RL. PMID: 22480467; PMCID: PMC3321216.
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    124. Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-terminal kinase pathway. Arthritis Res Ther. 2012 Feb 21; 14(1):R38. Lee SI, Boyle DL, Berdeja A, Firestein GS. PMID: 22353730; PMCID: PMC3392838.
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    125. The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon. Ann Rheum Dis. 2012 Mar; 71(3):440-7. Rosengren S, Corr M, Firestein GS, Boyle DL. PMID: 22121136.
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    126. Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient mice. Arthritis Rheum. 2011 Oct; 63(10):2949-55. Luo Y, Boyle DL, Hammaker D, Edgar M, Franzoso G, Firestein GS. PMID: 21702006; PMCID: PMC3183142.
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    127. A systems biology approach to synovial joint lubrication in health, injury, and disease. Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb; 4(1):15-37. Hui AY, McCarty WJ, Masuda K, Firestein GS, Sah RL. PMID: 21826801; PMCID: PMC3593048.
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    128. JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. Arthritis Rheum. 2011 Jun; 63(6):1603-12. Guma M, Ronacher LM, Firestein GS, Karin M, Corr M. PMID: 21305529; PMCID: PMC3106119.
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    129. Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis. Rheumatology (Oxford). 2012 Apr; 51(4):610-8. Hammaker D, Boyle DL, Firestein GS. PMID: 21613249; PMCID: PMC3306173.
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    130. A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis. J Rheumatol. 2011 May; 38(5):846-54. Genovese MC, Cohen SB, Wofsy D, Weinblatt ME, Firestein GS, Brahn E, Strand V, Baker DG, Tong SE. PMID: 21285160.
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    131. Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis. Ann Rheum Dis. 2011 May; 70(5):858-63. Corr M, Boyle DL, Ronacher LM, Lew BR, van Baarsen LG, Tak PP, Firestein GS. PMID: 21216819; PMCID: PMC3728888.
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    132. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22122-7. Guma M, Kashiwakura J, Crain B, Kawakami Y, Beutler B, Firestein GS, Kawakami T, Karin M, Corr M. PMID: 21135226; PMCID: PMC3009768.
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    133. Role of interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression. PLoS One. 2010 Oct 15; 5(10):e13416. Toh ML, Gonzales G, Koenders MI, Tournadre A, Boyle D, Lubberts E, Zhou Y, Firestein GS, van den Berg WB, Miossec P. PMID: 20976214; PMCID: PMC2955522.
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    134. Regulation of peripheral inflammation by the central nervous system. Curr Rheumatol Rep. 2010 Oct; 12(5):370-8. Waldburger JM, Firestein GS. PMID: 20676807; PMCID: PMC2927688.
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    135. Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis. Pain. 2010 Nov; 151(2):394-403. Christianson CA, Corr M, Firestein GS, Mobargha A, Yaksh TL, Svensson CI. PMID: 20739123; PMCID: PMC2955775.
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    136. Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J Leukoc Biol. 2010 Oct; 88(4):769-78. Gorovoy M, Gaultier A, Campana WM, Firestein GS, Gonias SL. PMID: 20610799; PMCID: PMC2974427.
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    137. Synoviocyte innate immune responses: II. Pivotal role of IFN regulatory factor 3. J Immunol. 2010 Jun 15; 184(12):7162-8. Sweeney SE, Kimbler TB, Firestein GS. PMID: 20483755; PMCID: PMC2913682.
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    138. Semi-permeable membrane retention of synovial fluid lubricants hyaluronan and proteoglycan 4 for a biomimetic bioreactor. Biotechnol Bioeng. 2010 May 01; 106(1):149-60. Blewis ME, Lao BJ, Jadin KD, McCarty WJ, Bugbee WD, Firestein GS, Sah RL. PMID: 20014439; PMCID: PMC2913685.
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    139. Interactive cytokine regulation of synoviocyte lubricant secretion. Tissue Eng Part A. 2010 Apr; 16(4):1329-37. Blewis ME, Lao BJ, Schumacher BL, Bugbee WD, Sah RL, Firestein GS. PMID: 19908966; PMCID: PMC2862605.
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    140. Metabolism: from bench to bedside. Nat Med. 2010 Apr; 16(4):387. Firestein GS. PMID: 20376049.
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    141. Mr Outside and Mr Inside: classic and alternative views on the pathogenesis of rheumatoid arthritis. Ann Rheum Dis. 2010 May; 69(5):787-9. Schett G, Firestein GS. PMID: 20299352.
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    142. 'Rac'-ing upstream to treat rheumatoid arthritis. Arthritis Res Ther. 2010; 12(1):109. Firestein GS. PMID: 20236447; PMCID: PMC2875651.
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    143. Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis Rheum. 2010 Feb; 62(2):441-51. Scatizzi JC, Hutcheson J, Pope RM, Firestein GS, Koch AE, Mavers M, Smason A, Agrawal H, Haines GK, Chandel NS, Hotchkiss RS, Perlman H. PMID: 20112357; PMCID: PMC2848986.
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    144. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev. 2010 Jan; 233(1):233-55. Bartok B, Firestein GS. PMID: 20193003; PMCID: PMC2913689.
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    145. Somatic mutations and anti-mutated citrullinated vimentin antibodies in rheumatoid arthritis: comment on the editorial by Levesque et al. Arthritis Rheum. 2010 Jan; 62(1):303-4. Firestein GS. PMID: 20039399; PMCID: PMC2858003.
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    146. "Go upstream, young man": lessons learned from the p38 saga. Ann Rheum Dis. 2010 Jan; 69 Suppl 1:i77-82. Hammaker D, Firestein GS. PMID: 19995751; PMCID: PMC2911016.
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    147. Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release. Ann Rheum Dis. 2010 May; 69(5):903-9. Kolker SJ, Walder RY, Usachev Y, Hillman J, Boyle DL, Firestein GS, Sluka KA. PMID: 19933746; PMCID: PMC3476728.
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    148. Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling. Arthritis Rheum. 2009 Nov; 60(11):3229-40. Svensson CI, Inoue T, Hammaker D, Fukushima A, Papa S, Franzoso G, Schett G, Corr M, Boyle DL, Firestein GS. PMID: 19877043; PMCID: PMC2858378.
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    149. Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression. J Immunol. 2009 Jul 15; 183(2):1360-7. Yoshizawa T, Hammaker D, Boyle DL, Corr M, Flavell R, Davis R, Schett G, Firestein GS. PMID: 19561096; PMCID: PMC2744479.
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    150. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity. 2009 Jun 19; 30(6):875-87. Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM. PMID: 19501000; PMCID: PMC2759865.
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    151. Kinetic analysis of synovial signalling and gene expression in animal models of arthritis. Ann Rheum Dis. 2010 May; 69(5):918-23. Fukushima A, Boyle DL, Corr M, Firestein GS. PMID: 19473996; PMCID: PMC2859101.
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    152. MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice. Neuroscience. 2009 Aug 18; 162(2):462-71. Sorkin LS, Boyle DL, Hammaker D, Herman DS, Vail E, Firestein GS. PMID: 19427893; PMCID: PMC2802055.
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    153. Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2009 Apr; 60(4):1102-11. Khanna D, Clements PJ, Furst DE, Korn JH, Ellman M, Rothfield N, Wigley FM, Moreland LW, Silver R, Kim YH, Steen VD, Firestein GS, Kavanaugh AF, Weisman M, Mayes MD, Collier D, Csuka ME, Simms R, Merkel PA, Medsger TA, Sanders ME, Maranian P, Seibold JR, Relaxin Investigators and the Scleroderma Clinical Trials Consortium. PMID: 19333948; PMCID: PMC3711466.
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    154. An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis. J Pharmacol Exp Ther. 2009 Jun; 329(3):1100-9. Offner H, Firestein GS, Boyle DL, Pieters R, Frincke JM, Garsd A, White SK, Reading CL, Auci DL. PMID: 19297421.
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    155. Garden of therapeutic delights: new targets in rheumatic diseases. Arthritis Res Ther. 2009; 11(1):206. Waldburger JM, Firestein GS. PMID: 19232066; PMCID: PMC2688217.
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    156. Telomerase transduced osteoarthritis fibroblast-like synoviocytes display a distinct gene expression profile. J Rheumatol. 2009 Jan; 36(1):141-55. Sun Y, Mauerhan DR, Firestein GS, Loeffler BJ, Hanley EN, Gruber HE. PMID: 19040300; PMCID: PMC2689317.
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    157. Rheumatoid arthritis in a mouse? Nat Clin Pract Rheumatol. 2009 Jan; 5(1):1. Firestein GS. PMID: 19098924; PMCID: PMC2754140.
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    158. Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor. Arthritis Rheum. 2008 Nov; 58(11):3439-49. Waldburger JM, Boyle DL, Pavlov VA, Tracey KJ, Firestein GS. PMID: 18975306; PMCID: PMC4476299.
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    159. Acoustic trauma augments the cochlear immune response to antigen. Laryngoscope. 2008 Oct; 118(10):1801-8. Miyao M, Firestein GS, Keithley EM. PMID: 18806477; PMCID: PMC2832795.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCellsPHPublic Health
    160. Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: a histological, gene expression and dynamic magnetic resonance imaging pilot study. Ann Rheum Dis. 2009 Jul; 68(7):1220-7. Buch MH, Boyle DL, Rosengren S, Saleem B, Reece RJ, Rhodes LA, Radjenovic A, English A, Tang H, Vratsanos G, O'Connor P, Firestein GS, Emery P. PMID: 18772191; PMCID: PMC2689522.
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    161. Spinal p38 MAP kinase regulates peripheral cholinergic outflow. Arthritis Rheum. 2008 Sep; 58(9):2919-21. Waldburger JM, Boyle DL, Edgar M, Sorkin LS, Levine YA, Pavlov VA, Tracey K, Firestein GS. PMID: 18759350; PMCID: PMC4533855.
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    162. Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases. J Immunol. 2008 Sep 01; 181(5):3252-8. Yoshizawa T, Hammaker D, Sweeney SE, Boyle DL, Firestein GS. PMID: 18713996; PMCID: PMC2725405.
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    163. Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta. Ann Rheum Dis. 2009 Feb; 68(2):257-63. Corr M, Boyle DL, Ronacher L, Flores N, Firestein GS. PMID: 18653628; PMCID: PMC2713581.
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    164. Primer: signal transduction in rheumatic disease--a clinician's guide. Nat Clin Pract Rheumatol. 2007 Nov; 3(11):651-60. Sweeney SE, Firestein GS. PMID: 17968336.
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    165. Longterm culture of telomerase-transduced rheumatoid arthritis fibroblast-like synoviocytes display a distinct gene expression pattern. J Rheumatol. 2007 Oct; 34(10):1959-70. Sun Y, Firestein G, Boyle D, Gruber H, Cheung H. PMID: 17896808.
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    166. The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis. Ann Rheum Dis. 2008 Jul; 67(7):909-16. Schett G, Zwerina J, Firestein G. PMID: 17827184; PMCID: PMC2754165.
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    167. Regulation of apoptosis in fibroblast-like synoviocytes by the hypoxia-induced Bcl-2 family member Bcl-2/adenovirus E1B 19-kd protein-interacting protein 3. Arthritis Rheum. 2007 Sep; 56(9):2854-63. Kammouni W, Wong K, Ma G, Firestein GS, Gibson SB, El-Gabalawy HS. PMID: 17763440.
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    168. Vanadate, an inhibitor of stromelysin and collagenase expression, suppresses collagen induced arthritis. J Rheumatol. 2007 Sep; 34(9):1802-9. Oliver SJ, Firestein GS, Arsenault L, Cruz TF, Cheng TP, Banquerigo ML, Boyle DL, Brahn E. PMID: 17696279.
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    169. Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results. Ann Rheum Dis. 2008 Mar; 67(3):402-8. Kavanaugh A, Rosengren S, Lee SJ, Hammaker D, Firestein GS, Kalunian K, Wei N, Boyle DL. PMID: 17644541; PMCID: PMC2754142.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCellsCTClinical Trials
    170. Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3. Arthritis Rheum. 2007 Mar; 56(3):743-52. Sweeney SE, Mo L, Firestein GS. PMID: 17328045.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    171. Biomedicine. Every joint has a silver lining. Science. 2007 Feb 16; 315(5814):952-3. Firestein GS. PMID: 17303744.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    172. Acquisition, culture, and phenotyping of synovial fibroblasts. Methods Mol Med. 2007; 135:365-75. Rosengren S, Boyle DL, Firestein GS. PMID: 17951672.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    173. Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. Arthritis Res Ther. 2007; 9(3):R57. Hammaker DR, Boyle DL, Inoue T, Firestein GS. PMID: 17559674; PMCID: PMC2206340.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    174. Cardiac death in a patient with adult-onset Still's disease treated with the interleukin 1 receptor inhibitor anakinra. Ann Rheum Dis. 2007 Mar; 66(3):422-3. Ruiz PJ, Masliah E, Doherty TA, Quach A, Firestein GS. PMID: 17179171; PMCID: PMC1856013.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    175. Anakinra for the treatment of neonatal-onset multisystem inflammatory disease. Nat Clin Pract Rheumatol. 2006 Dec; 2(12):646-7. Hoffman HM, Firestein GS. PMID: 17133246.
      View in: PubMed   Mentions: 5     Fields:    
    176. A biomarker by any other name... Nat Clin Pract Rheumatol. 2006 Dec; 2(12):635. Firestein GS. PMID: 17133243.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    177. Mitogen activated protein kinase inhibitors: where are we now and where are we going? Ann Rheum Dis. 2006 Nov; 65 Suppl 3:iii83-8. Sweeney SE, Firestein GS. PMID: 17038480; PMCID: PMC1798373.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    178. Reduction of proinflammatory cytokine expression in the synovium by targeting IKKbeta in vivo in a rat model. Arthritis Rheum. 2006 Nov; 54(11):3716-8. Tas SW, Hajji N, Stenvers DJ, Firestein GS, Vervoordeldonk MJ, Tak PP. PMID: 17075886.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    179. Real-time quantitative PCR to detect changes in synovial gene expression in rheumatoid arthritis after corticosteroid treatment. Ann Rheum Dis. 2007 Apr; 66(4):545-7. Gerlag DM, Boyle DL, Rosengren S, Nash T, Tak PP, Firestein GS. PMID: 16984938; PMCID: PMC1856037.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    180. Effect of impact on chondrocyte viability during insertion of human osteochondral grafts. J Bone Joint Surg Am. 2006 Sep; 88(9):1934-43. Borazjani BH, Chen AC, Bae WC, Patil S, Sah RL, Firestein GS, Bugbee WD. PMID: 16951108.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    181. Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med. 2006 Sep; 3(9):e338. Boyle DL, Jones TL, Hammaker D, Svensson CI, Rosengren S, Albani S, Sorkin L, Firestein GS. PMID: 16953659; PMCID: PMC1560929.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    182. Amelioration of arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5. Hum Gene Ther. 2006 Aug; 17(8):821-32. Tas SW, Adriaansen J, Hajji N, Bakker AC, Firestein GS, Vervoordeldonk MJ, Tak PP. PMID: 16942442.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    183. Regulation of JNK by MKK-7 in fibroblast-like synoviocytes. Arthritis Rheum. 2006 Jul; 54(7):2127-35. Inoue T, Hammaker D, Boyle DL, Firestein GS. PMID: 16802349.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    184. Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc Natl Acad Sci U S A. 2006 Apr 04; 103(14):5484-9. Inoue T, Boyle DL, Corr M, Hammaker D, Davis RJ, Flavell RA, Firestein GS. PMID: 16567640; PMCID: PMC1459381.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    185. PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes. Arthritis Rheum. 2006 Feb; 54(2):587-92. Cha HS, Rosengren S, Boyle DL, Firestein GS. PMID: 16447235.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    186. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May; 317(2):571-8. Cha HS, Boyle DL, Inoue T, Schoot R, Tak PP, Pine P, Firestein GS. PMID: 16452391.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    187. Inhibiting inflammation in rheumatoid arthritis. N Engl J Med. 2006 Jan 05; 354(1):80-2. Firestein GS. PMID: 16394307.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    188. Transforming growth factor beta expression during an inner ear immune response. Ann Otol Rhinol Laryngol. 2006 Jan; 115(1):81-8. Satoh H, Billings P, Firestein GS, Harris JP, Keithley EM. PMID: 16466104.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    189. PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53. Arthritis Res Ther. 2006; 8(6):R157. You X, Boyle DL, Hammaker D, Firestein GS. PMID: 17014719; PMCID: PMC1794498.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    190. Synovial tissue analysis in clinical trials. J Rheumatol. 2005 Dec; 32(12):2481-4. Bresnihan B, Baeten D, Firestein GS, Fitzgerald OM, Gerlag DM, Haringman JJ, McInnes IB, Reece RJ, Smith MD, Ulfgren AK, Veale DJ, Tak PP, OMERACT 7 Special Interest Group. PMID: 16331792.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    191. Pathogenesis of rheumatoid arthritis: how early is early? Arthritis Res Ther. 2005; 7(4):157-9. Firestein GS. PMID: 15987499; PMCID: PMC1175047.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    192. Immunologic mechanisms in the pathogenesis of rheumatoid arthritis. J Clin Rheumatol. 2005 Jun; 11(3 Suppl):S39-44. Firestein GS. PMID: 16357749.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    193. Regulation of arthritis by p53: critical role of adaptive immunity. Arthritis Rheum. 2005 Jun; 52(6):1876-84. Simelyte E, Rosengren S, Boyle DL, Corr M, Green DR, Firestein GS. PMID: 15934085.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    194. Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes. J Immunol. 2005 May 15; 174(10):6424-30. Sweeney SE, Hammaker D, Boyle DL, Firestein GS. PMID: 15879144.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    195. Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intra-articular gene therapy. Ann Rheum Dis. 2005 Dec; 64(12):1677-84. Adriaansen J, Tas SW, Klarenbeek PL, Bakker AC, Apparailly F, Firestein GS, Jorgensen C, Vervoordeldonk MJ, Tak PP. PMID: 15878906; PMCID: PMC1755308.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    196. TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. J Immunol. 2005 Apr 15; 174(8):5016-23. Liu-Bryan R, Pritzker K, Firestein GS, Terkeltaub R. PMID: 15814732.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    197. Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes. J Immunol. 2005 Apr 01; 174(7):4301-6. Inoue T, Hammaker D, Boyle DL, Firestein GS. PMID: 15778394.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    198. Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis. Arthritis Rheum. 2005 Feb; 52(2):430-41. Kasperkovitz PV, Timmer TC, Smeets TJ, Verbeet NL, Tak PP, van Baarsen LG, Baltus B, Huizinga TW, Pieterman E, Fero M, Firestein GS, van der Pouw Kraan TC, Verweij CL. PMID: 15692990.
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    199. Common mechanisms in immune-mediated inflammatory disease. J Rheumatol Suppl. 2005 Feb; 73:8-13; discussion 29-30. Firestein GS, Corr M. PMID: 15693110.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    200. DNA mismatch repair enzyme expression in synovial tissue. Ann Rheum Dis. 2004 Dec; 63(12):1695-9. Simelyte E, Boyle DL, Firestein GS. PMID: 15547100; PMCID: PMC1754862.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    201. Innate immunity contributes to cochlear adaptive immune responses. Audiol Neurootol. 2005 Jan-Feb; 10(1):35-43. Hashimoto S, Billings P, Harris JP, Firestein GS, Keithley EM. PMID: 15567913.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    202. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet. 2004 Nov 13-19; 364(9447):1779-85. Hoffman HM, Rosengren S, Boyle DL, Cho JY, Nayar J, Mueller JL, Anderson JP, Wanderer AA, Firestein GS. PMID: 15541451; PMCID: PMC4321997.
      View in: PubMed   Mentions: 189     Fields:    Translation:Humans
    203. Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis. J Rheumatol. 2004 Nov; 31(11):2106-14. Cheon H, Boyle DL, Firestein GS. PMID: 15517620.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    204. Telomerase-transduced osteoarthritic fibroblast-like synoviocyte cell line. Biochem Biophys Res Commun. 2004 Oct 29; 323(4):1287-92. Sun Y, Firestein GS, Wenger L, Huang CY, Cheung HS. PMID: 15451436.
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    205. p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis. Arthritis Res Ther. 2005; 7(1):R12-8. Yamanishi Y, Boyle DL, Green DR, Keystone EC, Connor A, Zollman S, Firestein GS. PMID: 15642132; PMCID: PMC1064878.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    206. The T cell cometh: interplay between adaptive immunity and cytokine networks in rheumatoid arthritis. J Clin Invest. 2004 Aug; 114(4):471-4. Firestein GS. PMID: 15314683; PMCID: PMC503778.
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    207. NF-kappaB: Holy Grail for rheumatoid arthritis? Arthritis Rheum. 2004 Aug; 50(8):2381-6. Firestein GS. PMID: 15334448.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    208. P53 down-regulates matrix metalloproteinase-1 by targeting the communications between AP-1 and the basal transcription complex. J Cell Biochem. 2004 May 15; 92(2):258-69. Sun Y, Zeng XR, Wenger L, Firestein GS, Cheung HS. PMID: 15108353.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    209. Signal transduction in rheumatoid arthritis. Curr Opin Rheumatol. 2004 May; 16(3):231-7. Sweeney SE, Firestein GS. PMID: 15103250.
      View in: PubMed   Mentions: 42  Translation:HumansCells
    210. Rheumatoid arthritis: regulation of synovial inflammation. Int J Biochem Cell Biol. 2004 Mar; 36(3):372-8. Sweeney SE, Firestein GS. PMID: 14687914.
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    211. Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis. J Immunol. 2004 Feb 01; 172(3):1612-8. Hammaker DR, Boyle DL, Chabaud-Riou M, Firestein GS. PMID: 14734742.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    212. Expression and activation of mitogen-activated protein kinase kinases-3 and -6 in rheumatoid arthritis. Am J Pathol. 2004 Jan; 164(1):177-84. Chabaud-Riou M, Firestein GS. PMID: 14695331; PMCID: PMC1602215.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    213. Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2004 Jan; 50(1):78-87. Bradley K, Scatizzi JC, Fiore S, Shamiyeh E, Koch AE, Firestein GS, Gorges LL, Kuntsman K, Pope RM, Moore TL, Han J, Perlman H. PMID: 14730602.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    214. p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion. Ann Rheum Dis. 2003 Dec; 62(12):1139-44. Seemayer CA, Kuchen S, Neidhart M, Kuenzler P, Rihosková V, Neumann E, Pruschy M, Aicher WK, Müller-Ladner U, Gay RE, Michel BA, Firestein GS, Gay S. PMID: 14644850; PMCID: PMC1754413.
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    215. Signal transduction networks in rheumatoid arthritis. Ann Rheum Dis. 2003 Nov; 62 Suppl 2:ii86-9. Hammaker D, Sweeney S, Firestein GS. PMID: 14532158; PMCID: PMC1766749.
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    216. Measurement of inflammatory biomarkers in synovial tissue extracts by enzyme-linked immunosorbent assay. Clin Diagn Lab Immunol. 2003 Nov; 10(6):1002-10. Rosengren S, Firestein GS, Boyle DL. PMID: 14607859; PMCID: PMC262451.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    217. Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers. Exp Neurol. 2003 Nov; 184(1):162-8. Sorkin LS, Moore J, Boyle DL, Yang L, Firestein GS. PMID: 14637089.
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    218. Quantitative biomarker analysis of synovial gene expression by real-time PCR. Arthritis Res Ther. 2003; 5(6):R352-60. Boyle DL, Rosengren S, Bugbee W, Kavanaugh A, Firestein GS. PMID: 14680510; PMCID: PMC333415.
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    219. Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK. Arthritis Rheum. 2003 Sep; 48(9):2450-60. Sundarrajan M, Boyle DL, Chabaud-Riou M, Hammaker D, Firestein GS. PMID: 13130464.
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    220. Development of a phase III trial of hematopoietic stem cell transplantation for systemic lupus erythematosus. Bone Marrow Transplant. 2003 Aug; 32 Suppl 1:S49-51. Burt RK, Marmont A, Arnold R, Heipe F, Firestein GS, Carrier E, Hahn B, Barr W, Oyama Y, Snowden J, Kalunian K, Traynor A. PMID: 12931242.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    221. Proinflammatory cytokine expression in the endolymphatic sac during inner ear inflammation. J Assoc Res Otolaryngol. 2003 Jun; 4(2):139-47. Satoh H, Firestein GS, Billings PB, Harris JP, Keithley EM. PMID: 12943369; PMCID: PMC3202716.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    222. Evolving concepts of rheumatoid arthritis. Nature. 2003 May 15; 423(6937):356-61. Firestein GS. PMID: 12748655.
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    223. Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis. Neurosci Lett. 2003 Apr 10; 340(2):119-22. Sorkin LS, Maruyama K, Boyle DL, Yang L, Marsala M, Firestein GS. PMID: 12668251.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    224. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell. 2003 Mar 07; 112(5):645-57. Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS. PMID: 12628185; PMCID: PMC4480774.
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    225. Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis. J Immunol. 2003 Feb 15; 170(4):2214-20. Lee SH, Chang DK, Goel A, Boland CR, Bugbee W, Boyle DL, Firestein GS. PMID: 12574395.
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    226. IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts. J Immunol. 2003 Jan 15; 170(2):838-45. Perlman H, Bradley K, Liu H, Cole S, Shamiyeh E, Smith RC, Walsh K, Fiore S, Koch AE, Firestein GS, Haines GK, Pope RM. PMID: 12517948.
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    227. Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis. Arthritis Rheum. 2002 Nov; 46(11):3076-82. Boyle DL, Moore J, Yang L, Sorkin LS, Firestein GS. PMID: 12428252.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    228. Tumor necrosis factor-alpha, an initiator, and etanercept, an inhibitor of cochlear inflammation. Laryngoscope. 2002 Sep; 112(9):1627-34. Satoh H, Firestein GS, Billings PB, Harris JP, Keithley EM. PMID: 12352677.
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    229. Regional analysis of p53 mutations in rheumatoid arthritis synovium. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10025-30. Yamanishi Y, Boyle DL, Rosengren S, Green DR, Zvaifler NJ, Firestein GS. PMID: 12119414; PMCID: PMC126618.
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    230. Innate immunity as a hired gun: but is it rheumatoid arthritis? J Exp Med. 2002 Apr 15; 195(8):F33-5. Corr M, Firestein GS. PMID: 11956300; PMCID: PMC2193686.
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    231. DNA microarrays: boundless technology or bound by technology? Guidelines for studies using microarray technology. Arthritis Rheum. 2002 Apr; 46(4):859-61. Firestein GS, Pisetsky DS. PMID: 11953960.
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    232. Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis. Arthritis Rheum. 2002 Mar; 46(3):818-23. Han Z, Chang L, Yamanishi Y, Karin M, Firestein GS. PMID: 11920420.
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    233. Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. J Immunol. 2002 Feb 01; 168(3):1405-12. Yamanishi Y, Boyle DL, Clark M, Maki RA, Tortorella MD, Arner EC, Firestein GS. PMID: 11801682.
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    234. How important are T cells in chronic rheumatoid synovitis?: II. T cell-independent mechanisms from beginning to end. Arthritis Rheum. 2002 Feb; 46(2):298-308. Firestein GS, Zvaifler NJ. PMID: 11840432.
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    235. The genetics of the target tissue in rheumatoid arthritis. Rheum Dis Clin North Am. 2002 Feb; 28(1):79-94. Corr M, Firestein GS. PMID: 11840699.
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    236. Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis. Am J Pathol. 2002 Jan; 160(1):123-30. Yamanishi Y, Boyle DL, Pinkoski MJ, Mahboubi A, Lin T, Han Z, Zvaifler NJ, Green DR, Firestein GS. PMID: 11786406; PMCID: PMC1867134.
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    237. Immunostimulatory DNA sequences influence the course of adjuvant arthritis. J Immunol. 2002 Jan 01; 168(1):51-6. Ronaghy A, Prakken BJ, Takabayashi K, Firestein GS, Boyle D, Zvailfler NJ, Roord ST, Albani S, Carson DA, Raz E. PMID: 11751945.
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    238. Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes. Cell Immunol. 2001 Nov 25; 214(1):54-9. Aupperle KR, Yamanishi Y, Bennett BL, Mercurio F, Boyle DL, Firestein GS. PMID: 11902829.
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    239. Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature. Arthritis Res. 2001; 3(6):357-61. Gerlag DM, Borges E, Tak PP, Ellerby HM, Bredesen DE, Pasqualini R, Ruoslahti E, Firestein GS. PMID: 11714389; PMCID: PMC64846.
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    240. Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation. Arthritis Rheum. 2001 Aug; 44(8):1897-907. Tak PP, Gerlag DM, Aupperle KR, van de Geest DA, Overbeek M, Bennett BL, Boyle DL, Manning AM, Firestein GS. PMID: 11508443.
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    241. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001 Jul; 108(1):73-81. Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS. PMID: 11435459; PMCID: PMC209341.
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    242. Pathogenesis of rheumatoid arthritis: the role of synoviocytes. Rheum Dis Clin North Am. 2001 May; 27(2):355-71. Yamanishi Y, Firestein GS. PMID: 11396097.
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    243. VIP: a very important protein in arthritis. Nat Med. 2001 May; 7(5):537-8. Firestein GS. PMID: 11329051.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    244. Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion. Arthritis Rheum. 2001 Mar; 44(3):676-81. Pap T, Aupperle KR, Gay S, Firestein GS, Gay RE. PMID: 11263783.
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    245. NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes. J Immunol. 2001 Feb 15; 166(4):2705-11. Aupperle K, Bennett B, Han Z, Boyle D, Manning A, Firestein G. PMID: 11160335.
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    246. Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism. J Clin Invest. 2001 Feb; 107(3):305-15. Burger JA, Zvaifler NJ, Tsukada N, Firestein GS, Kipps TJ. PMID: 11160154; PMCID: PMC199194.
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    247. Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis. J Pharmacol Exp Ther. 2001 Feb; 296(2):495-500. Boyle DL, Kowaluk EA, Jarvis MF, Lee CH, Bhagwat SS, Williams M, Firestein GS. PMID: 11160636.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    248. Adenosine kinase inhibitor GP515 improves experimental colitis in mice. J Pharmacol Exp Ther. 2001 Jan; 296(1):99-105. Siegmund B, Rieder F, Albrich S, Wolf K, Bidlingmaier C, Firestein GS, Boyle D, Lehr HA, Loher F, Hartmann G, Endres S, Eigler A. PMID: 11123368.
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    249. NF-kappaB: a key role in inflammatory diseases. J Clin Invest. 2001 Jan; 107(1):7-11. Tak PP, Firestein GS. PMID: 11134171; PMCID: PMC198552.
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    250. Modulation of fibroblast-mediated cartilage degradation by articular chondrocytes in rheumatoid arthritis. Arthritis Rheum. 2000 Nov; 43(11):2531-6. Pap T, van der Laan WH, Aupperle KR, Gay RE, Verheijen JH, Firestein GS, Gay S, Neidhart M. PMID: 11083277.
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    251. The effect of a T cell-specific NF-kappa B inhibitor on in vitro cytokine production and collagen-induced arthritis. J Immunol. 2000 Aug 01; 165(3):1652-8. Gerlag DM, Ransone L, Tak PP, Han Z, Palanki M, Barbosa MS, Boyle D, Manning AM, Firestein GS. PMID: 10903776.
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    252. Suppression of TNF-alpha production in human mononuclear cells by an adenosine kinase inhibitor. J Leukoc Biol. 2000 Jul; 68(1):97-103. Eigler A, Matschke V, Hartmann G, Erhardt S, Boyle D, Firestein GS, Endres S. PMID: 10914495.
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    253. Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis. J Rheumatol. 2000 Apr; 27(4):983-9. Goater J, Müller R, Kollias G, Firestein GS, Sanz I, O'Keefe RJ, Schwarz EM. PMID: 10782827.
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    254. Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2791-6. Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M, Carson DA. PMID: 10688908; PMCID: PMC16008.
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    255. Apoptosis and p53 expression in rat adjuvant arthritis. Arthritis Res. 2000; 2(3):229-35. Tak PP, Klapwijk MS, Broersen SF, van de Geest DA, Overbeek M, Firestein GS. PMID: 11056668; PMCID: PMC17810.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    256. Regulation of CS1 fibronectin expression and function by IL-1 in endothelial cells. Cell Immunol. 2000 Feb 25; 200(1):1-7. Boyle DL, Shi Y, Gay S, Firestein GS. PMID: 10716877.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    257. Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases. Immunol Today. 2000 Feb; 21(2):78-82. Tak PP, Zvaifler NJ, Green DR, Firestein GS. PMID: 10652465.
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    258. Gene-marked autologous hematopoietic stem cell transplantation of autoimmune disease. J Clin Immunol. 2000 Jan; 20(1):1-9. Burt RK, Brenner M, Burns W, Courier E, Firestein G, Hahn B, Heslop H, Link C, McFarland H, Roland M, Territo M, Tsokos G, Traynor A. PMID: 10798601.
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    259. Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced th2activity. Gene Ther. 1999 Dec; 6(12):1911-8. Boyle DL, Nguyen KH, Zhuang S, Shi Y, McCormack JE, Chada S, Firestein GS. PMID: 10637442.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    260. Jun N-terminal kinase in rheumatoid arthritis. J Pharmacol Exp Ther. 1999 Oct; 291(1):124-30. Han Z, Boyle DL, Aupperle KR, Bennett B, Manning AM, Firestein GS. PMID: 10490895.
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    261. Analysis of the p53 tumor suppressor gene in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 1999 Aug; 42(8):1594-600. Kullmann F, Judex M, Neudecker I, Lechner S, Jüsten HP, Green DR, Wessinghage D, Firestein GS, Gay S, Schölmerich J, Müller-Ladner U. PMID: 10446856.
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    262. NF-kappa B regulation by I kappa B kinase in primary fibroblast-like synoviocytes. J Immunol. 1999 Jul 01; 163(1):427-33. Aupperle KR, Bennett BL, Boyle DL, Tak PP, Manning AM, Firestein GS. PMID: 10384145.
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    263. Dominant-negative p53 mutations in rheumatoid arthritis. Arthritis Rheum. 1999 Jun; 42(6):1088-92. Han Z, Boyle DL, Shi Y, Green DR, Firestein GS. PMID: 10366100.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    264. p53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis. Arthritis Rheum. 1999 May; 42(5):948-53. Tak PP, Smeets TJ, Boyle DL, Kraan MC, Shi Y, Zhuang S, Zvaifler NJ, Breedveld FC, Firestein GS. PMID: 10323450.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    265. Signal transduction and transcription factors in rheumatic disease. Arthritis Rheum. 1999 Apr; 42(4):609-21. Firestein GS, Manning AM. PMID: 10211874.
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    266. Starving the synovium: angiogenesis and inflammation in rheumatoid arthritis. J Clin Invest. 1999 Jan; 103(1):3-4. Firestein GS. PMID: 9884327; PMCID: PMC407872.
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    267. Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action. J Rheumatol. 1998 Sep; 25(9):1785-93. Brahn E, Banquerigo ML, Firestein GS, Boyle DL, Salzman AL, Szabó C. PMID: 9733461.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    268. Direct synovial gene transfer with retroviral vectors in rat adjuvant arthritis. J Rheumatol. 1998 Jun; 25(6):1118-25. Nguyen KH, Boyle DL, McCormack JE, Chada S, Jolly DJ, Firestein GS. PMID: 9632074.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    269. Novel therapeutic strategies involving animals, arthritis, and apoptosis. Curr Opin Rheumatol. 1998 May; 10(3):236-41. Firestein GS. PMID: 9608326.
      View in: PubMed   Mentions: 1  Translation:HumansAnimals
    270. Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene. Am J Pathol. 1998 Apr; 152(4):1091-8. Aupperle KR, Boyle DL, Hendrix M, Seftor EA, Zvaifler NJ, Barbosa M, Firestein GS. PMID: 9546370; PMCID: PMC1858248.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    271. AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity. 1998; 28(4):197-208. Han Z, Boyle DL, Manning AM, Firestein GS. PMID: 9892501.
      View in: PubMed   Mentions: 100     Fields:    Translation:Animals
    272. Adenosine kinase inhibitor GP515 attenuates hepatic leukocyte adhesion after hemorrhagic hypotension. Am J Physiol. 1997 12; 273(6):G1297-303. Bauer C, Bouma MG, Herrmann I, van den Wildenberg FA, Firestein GS, Marzi I, Buurman WA. PMID: 9435554.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    273. Alternatively spliced CS-1 fibronectin isoform and its receptor VLA-4 in rheumatoid arthritis synovium. J Rheumatol. 1997 Oct; 24(10):1873-80. Müller-Ladner U, Elices MJ, Kriegsmann JB, Strahl D, Gay RE, Firestein GS, Gay S. PMID: 9330926.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    274. Posttranscriptional regulation of collagenase-1 gene expression in synoviocytes by adenosine receptor stimulation. Arthritis Rheum. 1997 Oct; 40(10):1772-9. Boyle DL, Han Z, Rutter JL, Brinckerhoff CE, Firestein GS. PMID: 9336410.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    275. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10895-900. Firestein GS, Echeverri F, Yeo M, Zvaifler NJ, Green DR. PMID: 9380731; PMCID: PMC23522.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCells
    276. Effect of tenidap on metalloproteinase gene expression in rheumatoid arthritis: a synovial biopsy study. J Clin Rheumatol. 1997 Aug; 3(4):194-202. Littman BH, Schumacher HR, Boyle DL, Weisman MH, Firestein GS. PMID: 19078187.
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    277. Anticytokine therapy in rheumatoid arthritis. N Engl J Med. 1997 Jul 17; 337(3):195-7. Firestein GS, Zvaifler NJ. PMID: 9219708.
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    278. Pannocytes: distinctive cells found in rheumatoid arthritis articular cartilage erosions. Am J Pathol. 1997 Mar; 150(3):1125-38. Zvaifler NJ, Tsai V, Alsalameh S, von Kempis J, Firestein GS, Lotz M. PMID: 9060847; PMCID: PMC1857892.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    279. Dual activation of adenosine A1 and A3 receptors mediates preconditioning of isolated cardiac myocytes. Eur J Pharmacol. 1997 Feb 12; 320(2-3):241-8. Wang J, Drake L, Sajjadi F, Firestein GS, Mullane KM, Bullough DA. PMID: 9059860.
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    280. Spinal cord adenosine receptor stimulation in rats inhibits peripheral neutrophil accumulation. The role of N-methyl-D-aspartate receptors. J Clin Invest. 1996 Dec 15; 98(12):2779-85. Bong GW, Rosengren S, Firestein GS. PMID: 8981924; PMCID: PMC507743.
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    281. Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium. Am J Pathol. 1996 Dec; 149(6):2143-51. Firestein GS, Nguyen K, Aupperle KR, Yeo M, Boyle DL, Zvaifler NJ. PMID: 8952546; PMCID: PMC1865342.
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    282. Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum. 1996 Nov; 39(11):1781-90. Firestein GS. PMID: 8912499.
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    283. Carbohydrate- and CD18-dependent neutrophil adhesion to cardiac myocytes: effects of adenosine. Cardiovasc Res. 1996 Aug; 32(2):328-34. Bullough DA, Magill MJ, Mullane KM, Firestein GS. PMID: 8796120.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    284. Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells. Curr Eye Res. 1996 Aug; 15(8):869-75. Lindsey JD, Kashiwagi K, Boyle D, Kashiwagi F, Firestein GS, Weinreb RN. PMID: 8921230.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    285. Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation. Arthritis Rheum. 1996 Jun; 39(6):923-30. Boyle DL, Sajjadi FG, Firestein GS. PMID: 8651985.
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    286. Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors. J Immunol. 1996 May 01; 156(9):3435-42. Sajjadi FG, Takabayashi K, Foster AC, Domingo RC, Firestein GS. PMID: 8617970.
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    287. Relapsing polychondritis and pregnancy: normal fetal outcome despite maternal flares. J Clin Rheumatol. 1996 Apr; 2(2):118. Krakow D, Greenspoon JS, Firestein GS. PMID: 19078043.
      View in: PubMed   Mentions:    Fields:    
    288. cDNA cloning and characterization of A3i, an alternatively spliced rat A3 adenosine receptor variant. FEBS Lett. 1996 Mar 11; 382(1-2):125-9. Sajjadi FG, Boyle DL, Domingo RC, Firestein GS. PMID: 8612733.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    289. Quantitative analysis of interleukin-1-alpha gene expression in middle ear cholesteatoma. Laryngoscope. 1996 Feb; 106(2 Pt 1):217-20. Bujía J, Kim C, Boyle D, Hammer C, Firestein G, Kastenbauer E. PMID: 8583857.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    290. Apoptosis in rheumatoid arthritis synovium. J Clin Invest. 1995 Sep; 96(3):1631-8. Firestein GS, Yeo M, Zvaifler NJ. PMID: 7657832; PMCID: PMC185789.
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    291. Adenosine activates A2 receptors to inhibit neutrophil adhesion and injury to isolated cardiac myocytes. J Immunol. 1995 Sep 01; 155(5):2579-86. Bullough DA, Magill MJ, Firestein GS, Mullane KM. PMID: 7650388.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    292. The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine. Arthritis Rheum. 1995 Aug; 38(8):1040-5. Cronstein BN, Naime D, Firestein G. PMID: 7662029.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    293. Anti-inflammatory effects of an adenosine kinase inhibitor. Decreased neutrophil accumulation and vascular leakage. J Immunol. 1995 May 15; 154(10):5444-51. Rosengren S, Bong GW, Firestein GS. PMID: 7730646.
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    294. Cytokine networks in rheumatoid arthritis: implications for therapy. Agents Actions Suppl. 1995; 47:37-51. Firestein GS. PMID: 7785502.
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    295. Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins. J Immunol. 1995 Jan 01; 154(1):326-34. Firestein GS, Bullough DA, Erion MD, Jimenez R, Ramirez-Weinhouse M, Barankiewicz J, Smith CW, Gruber HE, Mullane KM. PMID: 7527814.
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    296. Protection of mice from endotoxic death by 2-methylthio-ATP. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):6017-20. Proctor RA, Denlinger LC, Leventhal PS, Daugherty SK, van de Loo JW, Tanke T, Firestein GS, Bertics PJ. PMID: 8016108; PMCID: PMC44128.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    297. Protective effect of an adenosine kinase inhibitor in septic shock. J Immunol. 1994 Jun 15; 152(12):5853-9. Firestein GS, Boyle D, Bullough DA, Gruber HE, Sajjadi FG, Montag A, Sambol B, Mullane KM. PMID: 8207212.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    298. Regulation of granulocyte macrophage colony stimulating factor production by human articular chondrocytes. Induction by both tumor necrosis factor-alpha and interleukin 1, downregulation by transforming growth factor beta and upregulation by fibroblast growth factor. J Rheumatol. 1994 Jun; 21(6):993-1002. Alsalameh S, Firestein GS, Oez S, Kurrle R, Kalden JR, Burmester GR. PMID: 7932447.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    299. Pannus and pannocytes. Alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum. 1994 Jun; 37(6):783-9. Zvaifler NJ, Firestein GS. PMID: 8003048.
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    300. Early synovitis--synoviocytes and mononuclear cells. Semin Arthritis Rheum. 1994 Jun; 23(6 Suppl 2):11-6. Zvaifler NJ, Boyle D, Firestein GS. PMID: 7939726.
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    301. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis Rheum. 1994 May; 37(5):644-52. Firestein GS, Boyle DL, Yu C, Paine MM, Whisenand TD, Zvaifler NJ, Arend WP. PMID: 8185691.
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    302. Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression. Arthritis Rheum. 1994 Feb; 37(2):193-200. Firestein GS, Paine MM, Boyle DL. PMID: 8129774.
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    303. Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature. J Clin Invest. 1994 Jan; 93(1):405-16. Elices MJ, Tsai V, Strahl D, Goel AS, Tollefson V, Arrhenius T, Wayner EA, Gaeta FC, Fikes JD, Firestein GS. PMID: 8282813; PMCID: PMC293796.
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    304. Endogenous adenosine formation can regulate human neutrophil function. Adv Exp Med Biol. 1994; 370:417-21. Barankiewicz J, Jimenez R, Uyesaka J, Colmerauer E, Firestein GS. PMID: 7660941.
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    305. cDNA cloning and sequence analysis of the human A3 adenosine receptor. Biochim Biophys Acta. 1993 Oct 07; 1179(1):105-7. Sajjadi FG, Firestein GS. PMID: 8399349.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    306. The role of T cells in rheumatoid arthritis. Ann Rheum Dis. 1993 Oct; 52(10):765. Firestein GS, Zvaifler NJ. PMID: 8257214; PMCID: PMC1005176.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    307. Mutual antagonism between interferon-gamma and tumor necrosis factor-alpha on fibroblast-like synoviocytes: paradoxical induction of IFN-gamma and TNF-alpha receptor expression. J Clin Immunol. 1993 May; 13(3):212-8. Alvaro-Gracia JM, Yu C, Zvaifler NJ, Firestein GS. PMID: 8391545.
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    308. Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest. 1992 Oct; 90(4):1414-24. Broide DH, Paine MM, Firestein GS. PMID: 1401075; PMCID: PMC443187.
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    309. Cytokine-induced differentiation of cultured nonadherent macrophages. Cell Immunol. 1992 Oct 01; 144(1):203-16. Tsai V, Firestein GS, Arend W, Zvaifler NJ. PMID: 1382865.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    310. Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes. J Immunol. 1992 Aug 15; 149(4):1424-31. Morales-Ducret J, Wayner E, Elices MJ, Alvaro-Gracia JM, Zvaifler NJ, Firestein GS. PMID: 1380043.
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    311. IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium. J Immunol. 1992 Aug 01; 149(3):1054-62. Firestein GS, Berger AE, Tracey DE, Chosay JG, Chapman DL, Paine MM, Yu C, Zvaifler NJ. PMID: 1386092.
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    312. Stromelysin and tissue inhibitor of metalloproteinases gene expression in rheumatoid arthritis synovium. Am J Pathol. 1992 Jun; 140(6):1309-14. Firestein GS, Paine MM. PMID: 1605305; PMCID: PMC1886556.
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    313. Mechanisms of tissue destruction and cellular activation in rheumatoid arthritis. Curr Opin Rheumatol. 1992 Jun; 4(3):348-54. Firestein GS. PMID: 1599815.
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    314. Cytokines in autoimmune diseases. Concepts Immunopathol. 1992; 8:129-60. Firestein GS. PMID: 1735099.
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    315. Endobronchial allergen challenge in asthma. Demonstration of cellular source of granulocyte macrophage colony-stimulating factor by in situ hybridization. J Clin Invest. 1991 Sep; 88(3):1048-53. Broide DH, Firestein GS. PMID: 1885766; PMCID: PMC295519.
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    316. Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids. Arthritis Rheum. 1991 Sep; 34(9):1094-105. Firestein GS, Paine MM, Littman BH. PMID: 1657009.
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    317. The immunopathogenesis of rheumatoid arthritis. Curr Opin Rheumatol. 1991 Jun; 3(3):398-406. Firestein GS. PMID: 1883694.
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    318. Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha. J Immunol. 1991 May 15; 146(10):3365-71. Alvaro-Gracia JM, Zvaifler NJ, Brown CB, Kaushansky K, Firestein GS. PMID: 2026869.
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    319. Immunopathogenesis of rheumatoid arthritis. Immunol Ser. 1991; 54:141-61. Firestein GS, Zvaifler NJ. PMID: 1954274.
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    320. Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-gamma and tumor necrosis factor-alpha on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes. J Clin Invest. 1990 Dec; 86(6):1790-8. Alvaro-Gracia JM, Zvaifler NJ, Firestein GS. PMID: 2174906; PMCID: PMC329810.
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    321. How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum. 1990 Jun; 33(6):768-73. Firestein GS, Zvaifler NJ. PMID: 2194461.
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    322. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol. 1990 May 01; 144(9):3347-53. Firestein GS, Alvaro-Gracia JM, Maki R, Alvaro-Garcia JM. PMID: 2109776.
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    323. The effects of gamma-interferon on human peripheral blood monocyte/macrophage-mediated bone particle degradation. Bone Miner. 1990 Feb; 8(2):131-43. Terkeltaub R, Firestein GS, Kornbluth RS, Martin J, Curran D, Manolagas S. PMID: 2106359.
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    324. Cytokines in chronic inflammatory arthritis. III. Rheumatoid arthritis monocytes are not unusually sensitive to gamma-interferon, but have defective gamma-interferon-mediated HLA-DQ and HLA-DR induction. Arthritis Rheum. 1989 Sep; 32(9):1074-9. Bergroth V, Zvaifler NJ, Firestein GS. PMID: 2505778.
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    325. Transforming growth factor-beta 1 selectively inhibits IL-3-dependent mast cell proliferation without affecting mast cell function or differentiation. J Immunol. 1989 Sep 01; 143(5):1591-7. Broide DH, Wasserman SI, Alvaro-Gracia J, Zvaifler NJ, Firestein GS. PMID: 2527268.
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    326. Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis. J Exp Med. 1989 Sep 01; 170(3):865-75. Alvaro-Gracia JM, Zvaifler NJ, Firestein GS. PMID: 2504878; PMCID: PMC2189430.
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    327. A new murine CD4+ T cell subset with an unrestricted cytokine profile. J Immunol. 1989 Jul 15; 143(2):518-25. Firestein GS, Roeder WD, Laxer JA, Townsend KS, Weaver CT, Hom JT, Linton J, Torbett BE, Glasebrook AL. PMID: 2472442.
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    328. Cytokines in chronic inflammatory arthritis. II. Granulocyte-macrophage colony-stimulating factor in rheumatoid synovial effusions. J Clin Invest. 1989 Mar; 83(3):876-82. Xu WD, Firestein GS, Taetle R, Kaushansky K, Zvaifler NJ. PMID: 2646320; PMCID: PMC303761.
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    329. Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J Exp Med. 1988 Nov 01; 168(5):1573-86. Firestein GS, Xu WD, Townsend K, Broide D, Alvaro-Gracia J, Glasebrook A, Zvaifler NJ. PMID: 3263464; PMCID: PMC2189111.
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    330. Rapid and reversible modulation of T4 (CD4) on monocytoid cells by phorbol myristate acetate: effect on HIV susceptibility. Cell Immunol. 1988 Apr 15; 113(1):63-9. Firestein GS, Reifler D, Richman D, Gruber HE. PMID: 3365771.
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    331. Cytokines in chronic inflammatory synovitis. Scand J Rheumatol Suppl. 1988; 76:203-10. Zvaifler NJ, Firestein GS. PMID: 3150793.
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    332. The pathogenesis of rheumatoid arthritis. A critical assessment of the role of autologous stimulation in the perpetuation of rheumatoid synovitis. Rheum Dis Clin North Am. 1987 Dec; 13(3):447-61. Firestein GS, Zvaifler NJ. PMID: 3324200.
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    333. Quantitative molecular hybridization with unfractionated, solubilized cells using RNA probes and polyacrylamide gel electrophoresis. Anal Biochem. 1987 Dec; 167(2):381-6. Firestein GS, Gardner SM, Roeder WD. PMID: 2450487.
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    334. Cellular immunity in the joints of patients with rheumatoid arthritis and other forms of chronic synovitis. Rheum Dis Clin North Am. 1987 Aug; 13(2):191-213. Firestein GS, Tsai V, Zvaifler NJ. PMID: 3321208.
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    335. Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor. Arthritis Rheum. 1987 Aug; 30(8):864-71. Firestein GS, Zvaifler NJ. PMID: 3115274.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    336. Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. I. A cytofluorographic study of monocyte differentiation antigens and class II antigens and their regulation by gamma-interferon. Arthritis Rheum. 1987 Aug; 30(8):857-63. Firestein GS, Zvaifler NJ. PMID: 3115273.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    337. Down regulation of human monocyte differentiation antigens by interferon gamma. Cell Immunol. 1987 Feb; 104(2):343-54. Firestein GS, Zvaifler NJ. PMID: 3102077.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    338. Reactive arthritis. Annu Rev Med. 1987; 38:351-60. Firestein GS, Zvaifler NJ. PMID: 3555301.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    339. Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis. Ann Intern Med. 1986 Nov; 105(5):661-8. Alexander EL, Firestein GS, Weiss JL, Heuser RR, Leitl G, Wagner HN, Brinker JA, Ciuffo AA, Becker LC. PMID: 3767147.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    340. Deoxy-ATP accumulation in adenosine deaminase-inhibited human B and T lymphocytes. Adv Exp Med Biol. 1986; 195 Pt A:503-7. Gruber HE, Cohen AH, Firestein GS, Redelman D, Bluestein HG. PMID: 3487921.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    341. Mouth and genital ulcers with inflamed cartilage: MAGIC syndrome. Five patients with features of relapsing polychondritis and Behçet's disease. Am J Med. 1985 Jul; 79(1):65-72. Firestein GS, Gruber HE, Weisman MH, Zvaifler NJ, Barber J, O'Duffy JD. PMID: 4014306.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    342. Left ventricular function in presence of small pericardial effusion. Echocardiography study. Br Heart J. 1980 Apr; 43(4):382-7. Firestein G, Hensley C, Varghese PJ. PMID: 7397039; PMCID: PMC482296.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
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