Elsa Sanchez-lopez

Title(s)Assistant Professor In Residence, Orthopedic Surgery
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-4236-1985 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Complutense University, Madrid, SpainB.Sc.2001Biology.
    Autonoma University, Madrid, SpainPhD2008Biochemistry, Molecular Biology and Biomedicine.
    Spanish National Research Council-CSIC, Madrid, SpainSpecialist2001Techniques and Applications for cell culture
    Spanish National Research Council-CSIC. , Madrid, Spain.Specialist2002Medicinal chemistry, pharmacology, phamacokinetic and pharmacodynamics
    Complutense University, Madrid, Spain2003Teaching Certificate (CAP)
    Biomol Informatics. Autonoma University. , Madrid, Spain2009DNA Array Data Analysis
    Collapse Awards and Honors
    Health Institute Carlos III. 2003  - 2007PhD Fellowship for Research Education "BEFI" program
    Ministry of Agriculture and Comunidad Autonoma de Madrid. Spain 2007Accreditation of competition for the use and handling of experimental animals.
    Spanish Society of Cardiology, Madrid. Spain 2007Novartis Award.
    Autonoma University2008Outstanding “Cum Laude” PhD degree in Biochemistry, Molecular Biology and Biomedicine.
    School of Medicine of University Autonoma of Madrid. Spain 2009Extraordinary Doctorate Award
    Health Institute Carlos III. Spain2010  - 2013Postdoctoral Fellowship under the program "Sara Borrell"
    UCSD (P30/NIH)2019  - 2020Microenvironment in Arthritis research center (MARC) pilot project award.
    NIAMS NIH2020  - 2025K01 mentored research scientist development award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Role of choline metabolism in activated macrophage phenotypes
    NIH K01AR077111May 13, 2020 - Apr 30, 2025
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Role of mitochondria-bound HK2 in rheumatoid arthritis fibroblast-like synoviocytes. Front Immunol. 2023; 14:1103231. Torres A, Kang S, Mahony CB, Cedeño M, Oliveira PG, Fernandez-Bustamante M, Kemble S, Laragione T, Gulko PS, Croft AP, Sanchez-Lopez E, Miyamoto S, Guma M. PMID: 37529037; PMCID: PMC10389265.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    2. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 08 09; 55(8):1370-1385.e8. Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. PMID: 35835107; PMCID: PMC9378606.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    3. Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2022 07; 74(7):1159-1171. Torres A, Pedersen B, Cobo I, Ai R, Coras R, Murillo-Saich J, Nygaard G, Sanchez-Lopez E, Murphy A, Wang W, Firestein GS, Guma M. PMID: 35128827; PMCID: PMC9246826.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    4. Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response. Cell Rep. 2022 03 08; 38(10):110489. Cobo I, Cheng A, Murillo-Saich J, Coras R, Torres A, Abe Y, Lana AJ, Schlachetzki J, Liu-Bryan R, Terkeltaub R, Sanchez-Lopez E, Glass CK, Guma M. PMID: 35263587; PMCID: PMC8989403.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    5. Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol. 2022 05; 18(5):258-275. Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M. PMID: 35165404; PMCID: PMC9050956.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansCells
    6. Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18). Marek-Iannucci S, Ozdemir AB, Moreira D, Gomez AC, Lane M, Porritt RA, Lee Y, Shimada K, Abe M, Stotland A, Zemmour D, Parker S, Sanchez-Lopez E, Van Eyk J, Gottlieb RA, Fishbein MC, Karin M, Crother TR, Rivas MN, Arditi M. PMID: 34403365; PMCID: PMC8492304.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    7. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021 07 13; 54(7):1463-1477.e11. Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E. PMID: 34115964; PMCID: PMC8189765.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    8. NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia. Cell Death Differ. 2020 07; 27(7):2206-2216. Sanchez-Lopez E, Ghia EM, Antonucci L, Sharma N, Rassenti LZ, Xu J, Sun B, Kipps TJ, Karin M. PMID: 31992855; PMCID: PMC7308363.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    9. Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia. Blood. 2019 09 26; 134(13):1084-1094. Chen Y, Chen L, Yu J, Ghia EM, Choi MY, Zhang L, Zhang S, Sanchez-Lopez E, Widhopf GF, Messer K, Rassenti LZ, Jamieson C, Kipps TJ. PMID: 31409670; PMCID: PMC6764264.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    10. Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis. Front Immunol. 2019; 10:1743. de Oliveira PG, Farinon M, Sanchez-Lopez E, Miyamoto S, Guma M. PMID: 31428089; PMCID: PMC6688519.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    11. Can Metabolic Pathways Be Therapeutic Targets in Rheumatoid Arthritis? J Clin Med. 2019 May 27; 8(5). Sanchez-Lopez E, Cheng A, Guma M. PMID: 31137815; PMCID: PMC6572063.
      View in: PubMed   Mentions: 27  
    12. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell Metab. 2019 06 04; 29(6):1350-1362.e7. Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. PMID: 30982734; PMCID: PMC6675591.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    13. Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis. Ann Rheum Dis. 2018 11; 77(11):1636-1643. Bustamante MF, Oliveira PG, Garcia-Carbonell R, Croft AP, Smith JM, Serrano RL, Sanchez-Lopez E, Liu X, Kisseleva T, Hay N, Buckley CD, Firestein GS, Murphy AN, Miyamoto S, Guma M. PMID: 30061164; PMCID: PMC6328432.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    14. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. PMID: 30046112; PMCID: PMC6329306.
      View in: PubMed   Mentions: 497     Fields:    Translation:AnimalsCells
    15. Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases. Clin Exp Rheumatol. 2016 Jul-Aug; 34(4 Suppl 98):12-6. Zhong Z, Sanchez-Lopez E, Karin M. PMID: 27586797.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    16. Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment. Cell. 2016 Jul 14; 166(2):288-298. Zhong Z, Sanchez-Lopez E, Karin M. PMID: 27419869; PMCID: PMC4947210.
      View in: PubMed   Mentions: 294     Fields:    Translation:HumansAnimals
    17. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. PMID: 26919428; PMCID: PMC4769378.
      View in: PubMed   Mentions: 542     Fields:    Translation:AnimalsCells
    18. Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. Oncogene. 2016 05 19; 35(20):2634-44. Sanchez-Lopez E, Flashner-Abramson E, Shalapour S, Zhong Z, Taniguchi K, Levitzki A, Karin M. PMID: 26364612; PMCID: PMC4791217.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    19. Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 2015 May 07; 521(7550):94-8. Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M. PMID: 25924065; PMCID: PMC4501632.
      View in: PubMed   Mentions: 285     Fields:    Translation:HumansAnimalsCells
    20. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity. 2014 Dec 18; 41(6):1052-63. Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, Zhang W, Zhong Z, Sanchez-Lopez E, Wu LW, Taniguchi K, Feng Y, Fearon E, Grivennikov SI, Karin M. PMID: 25526314; PMCID: PMC4272447.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansAnimalsCells
    21. Choline kinase inhibition in rheumatoid arthritis. Ann Rheum Dis. 2015 Jul; 74(7):1399-407. Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS. PMID: 25274633; PMCID: PMC4382461.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    22. Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation. Clin Sci (Lond). 2014 Jul; 127(1):19-31. Alique M, Civantos E, Sanchez-Lopez E, Lavoz C, Rayego-Mateos S, Rodrigues-Díez R, García-Redondo AB, Egido J, Ortiz A, Rodríguez-Puyol D, Rodríguez-Puyol M, Ruiz-Ortega M. PMID: 24383472.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    23. Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells. Cell Death Dis. 2013 Nov 28; 4:e933. Sanchez-Lopez E, Zimmerman T, Gomez del Pulgar T, Moyer MP, Lacal Sanjuan JC, Cebrian A. PMID: 24287694; PMCID: PMC3847329.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    24. HSP27/HSPB1 as an adaptive podocyte antiapoptotic protein activated by high glucose and angiotensin II. Lab Invest. 2012 Jan; 92(1):32-45. Sanchez-Niño MD, Sanz AB, Sanchez-Lopez E, Ruiz-Ortega M, Benito-Martin A, Saleem MA, Mathieson PW, Mezzano S, Egido J, Ortiz A. PMID: 21931298.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    25. TGF-beta signaling in vascular fibrosis. Cardiovasc Res. 2007 May 01; 74(2):196-206. Ruiz-Ortega M, Rodríguez-Vita J, Sanchez-Lopez E, Carvajal G, Egido J. PMID: 17376414.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansAnimalsCells
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