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Jeffrey Omens

Title(s)Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0613J
La Jolla CA 92093
Phone8/5-34--8102
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    Collapse Research 
    Collapse Research Activities and Funding
    The Cardiac Atlas Project
    NIH/NHLBI R01HL121754Jan 1, 2014 - Jun 30, 2024
    Role: Principal Investigator
    Cardiomyocyte mechanotransduction through the integrin complex
    NIH/NHLBI R01HL103566Jul 15, 2010 - Apr 30, 2015
    Role: Principal Investigator
    MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    NIH/NHLBI R01HL064321Feb 1, 2001 - Jan 31, 2006
    Role: Principal Investigator
    STRESS AND STRAIN AS STIMULI FOR MYOCARDIAL GROWTH
    NIH/NHLBI R01HL054686Aug 1, 1996 - Jun 30, 2001
    Role: Principal Investigator
    STRESS AND STRAIN AS STIMULI FOR MYOCARDIAL GROWTH
    NIH/NHLBI R29HL054686Aug 1, 1996 - Jun 30, 2000
    Role: Principal Investigator
    NATIONAL BIOMEDICAL COMPUTATION RESOURCE
    NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
    Role: Co-Investigator
    VENTRICULAR TRANSMURAL DEFORMATION IN VOLUME OVERLOAD
    NIH/NHLBI F32HL008153Mar 27, 1990
    Role: Principal Investigator
    Transmural Deformation
    NIH/NHLBI R01HL032583Jul 1, 1984 - Mar 31, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Atlas-based measures of left ventricular shape may improve characterization of adverse remodeling in anthracycline-exposed childhood cancer survivors: a cross-sectional imaging study. Cardiooncology. 2020; 6:13. Narayan HK, Xu R, Forsch N, Govil S, Iukuridze D, Lindenfeld L, Adler E, Hegde S, Tremoulet A, Ky B, Armenian S, Omens J, McCulloch AD. PMID: 32782827.
      View in: PubMed   Mentions:
    2. Quantification of model and data uncertainty in a network analysis of cardiac myocyte mechanosignalling. Philos Trans A Math Phys Eng Sci. 2020 Jun 12; 378(2173):20190336. Cao S, Aboelkassem Y, Wang A, Valdez-Jasso D, Saucerman JJ, Omens JH, McCulloch AD. PMID: 32448062.
      View in: PubMed   Mentions: 1     Fields:    
    3. Regional variations in ex-vivo diffusion tensor anisotropy are associated with cardiomyocyte remodeling in rats after left ventricular pressure overload. J Cardiovasc Magn Reson. 2020 04 02; 22(1):21. Carruth ED, Teh I, Schneider JE, McCulloch AD, Omens JH, Frank LR. PMID: 32241289.
      View in: PubMed   Mentions:    Fields:    
    4. The role of inflammation in driving left ventricular remodeling in a pre-HFpEF model. Exp Biol Med (Maywood). 2020 Apr; 245(8):748-757. Loredo-Mendoza ML, Ramirez-Sanchez I, Bustamante-Pozo MM, Ayala M, Navarrete V, Garate-Carrillo A, Ito BR, Ceballos G, Omens J, Villarreal F. PMID: 32183553.
      View in: PubMed   Mentions:    Fields:    
    5. Improved compressed sensing and super-resolution of cardiac diffusion MRI with structure-guided total variation. Magn Reson Med. 2020 Oct; 84(4):1868-1880. Teh I, McClymont D, Carruth E, Omens J, McCulloch A, Schneider JE. PMID: 32125040.
      View in: PubMed   Mentions:    Fields:    
    6. Predictions of hypertrophy and its regression in response to pressure overload. Biomech Model Mechanobiol. 2020 Jun; 19(3):1079-1089. Yoshida K, McCulloch AD, Omens JH, Holmes JW. PMID: 31813071.
      View in: PubMed   Mentions:    Fields:    
    7. Mechanical regulation of gene expression in cardiac myocytes and fibroblasts. Nat Rev Cardiol. 2019 06; 16(6):361-378. Saucerman JJ, Tan PM, Buchholz KS, McCulloch AD, Omens JH. PMID: 30683889.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    8. Unmasking of oestrogen-dependent changes in left ventricular structure and function in aged female rats: a potential model for pre-heart failure with preserved ejection fraction. J Physiol. 2019 04; 597(7):1805-1817. Bustamante M, Garate-Carrillo A, R Ito B, Garcia R, Carson N, Ceballos G, Ramirez-Sanchez I, Omens J, Villarreal F. PMID: 30681142.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. An Iterative Diffeomorphic Algorithm for Registration of Subdivision Surfaces: Application to Congenital Heart Disease. Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:596-599. Mauger C, Gilbert K, Suinesiaputra A, Pontre B, Omens J, McCulloch A, Young A. PMID: 30440467.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Decreasing Compensatory Ability of Concentric Ventricular Hypertrophy in Aortic-Banded Rat Hearts. Front Physiol. 2018; 9:37. Lewalle A, Land S, Carruth E, Frank LR, Lamata P, Omens JH, McCulloch AD, Niederer SA, Smith NP. PMID: 29527171.
      View in: PubMed   Mentions:
    11. Atlas-Based Computational Analysis of Heart Shape and Function in Congenital Heart Disease. J Cardiovasc Transl Res. 2018 04; 11(2):123-132. Gilbert K, Forsch N, Hegde S, Mauger C, Omens JH, Perry JC, Pontré B, Suinesiaputra A, Young AA, McCulloch AD. PMID: 29294215.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Predictive model identifies key network regulators of cardiomyocyte mechano-signaling. PLoS Comput Biol. 2017 Nov; 13(11):e1005854. Tan PM, Buchholz KS, Omens JH, McCulloch AD, Saucerman JJ. PMID: 29131824.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    13. Model of Human Fetal Growth in Hypoplastic Left Heart Syndrome: Reduced Ventricular Growth Due to Decreased Ventricular Filling and Altered Shape. Front Pediatr. 2017; 5:25. Dewan S, Krishnamurthy A, Kole D, Conca G, Kerckhoffs R, Puchalski MD, Omens JH, Sun H, Nigam V, McCulloch AD. PMID: 28275592.
      View in: PubMed   Mentions:
    14. Vinculin at the heart of aging. Ann Transl Med. 2017 Feb; 5(3):62. Bradford WH, Omens JH, Sheikh F. PMID: 28251141.
      View in: PubMed   Mentions:
    15. Non-invasive, model-based measures of ventricular electrical dyssynchrony for predicting CRT outcomes. Europace. 2016 Dec; 18(suppl 4):iv104-iv112. Villongco CT, Krummen DE, Omens JH, McCulloch AD. PMID: 28011837.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    16. Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload. Prog Biophys Mol Biol. 2016 Dec; 122(3):215-226. Carruth ED, McCulloch AD, Omens JH. PMID: 27845176.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    17. Evaluation of non-Gaussian diffusion in cardiac MRI. Magn Reson Med. 2017 09; 78(3):1174-1186. McClymont D, Teh I, Carruth E, Omens J, McCulloch A, Whittington HJ, Kohl P, Grau V, Schneider JE. PMID: 27670633.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    18. Atlas-Based Ventricular Shape Analysis for Understanding Congenital Heart Disease. Prog Pediatr Cardiol. 2016 Dec; 43:61-69. Farrar G, Suinesiaputra A, Gilbert K, Perry JC, Hegde S, Marsden A, Young AA, Omens JH, McCulloch AD. PMID: 28082823.
      View in: PubMed   Mentions:
    19. Improving assessment of congenital heart disease through rapid patient specific modeling. Conf Proc IEEE Eng Med Biol Soc. 2016 08; 2016:1228-1231. Gilbert K, Farrar G, Cowan B, Suinesiaputra A, Occleshaw C, Pontre B, Perry J, Hegde S, Omens J, McCulloch A, Young A. PMID: 28268546.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Evidence for Mechanisms Underlying the Functional Benefits of a Myocardial Matrix Hydrogel for Post-MI Treatment. J Am Coll Cardiol. 2016 Mar 08; 67(9):1074-1086. Wassenaar JW, Gaetani R, Garcia JJ, Braden RL, Luo CG, Huang D, DeMaria AN, Omens JH, Christman KL. PMID: 26940929.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    21. Modifying Ventricular Fibrillation by Targeted Rotor Substrate Ablation: Proof-of-Concept from Experimental Studies to Clinical VF. J Cardiovasc Electrophysiol. 2015 Oct; 26(10):1117-26. Krummen DE, Hayase J, Vampola SP, Ho G, Schricker AA, Lalani GG, Baykaner T, Coe TM, Clopton P, Rappel WJ, Omens JH, Narayan SM. PMID: 26179310.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    22. High-order finite element methods for cardiac monodomain simulations. Front Physiol. 2015; 6:217. Vincent KP, Gonzales MJ, Gillette AK, Villongco CT, Pezzuto S, Omens JH, Holst MJ, McCulloch AD. PMID: 26300783.
      View in: PubMed   Mentions:
    23. Creating shape templates for patient specific biventricular modeling in congenital heart disease. Conf Proc IEEE Eng Med Biol Soc. 2015 08; 2015:679-82. Gilbert K, Farrar G, Cowan BR, Suinesiaputra A, Occleshaw C, Pontre B, Perry J, Hegde S, Marsden A, Omens J, McCulloch A, Young AA. PMID: 26736353.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Mechanotransduction in cardiac hypertrophy and failure. Circ Res. 2015 Apr 10; 116(8):1462-1476. Lyon RC, Zanella F, Omens JH, Sheikh F. PMID: 25858069.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    25. Left Ventricular Diastolic and Systolic Material Property Estimation from Image Data: LV Mechanics Challenge. Stat Atlases Comput Models Heart. 2015 Jan; 8896:63-73. Krishnamurthy A, Villongco C, Beck A, Omens J, McCulloch A. PMID: 25729778.
      View in: PubMed   Mentions:
    26. Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing. J Mol Cell Cardiol. 2014 Nov; 76:265-74. Pfeiffer ER, Wright AT, Edwards AG, Stowe JC, McNall K, Tan J, Niesman I, Patel HH, Roth DM, Omens JH, McCulloch AD. PMID: 25257915.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    27. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. PMID: 25236710.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    28. Patient-specific modeling of ventricular activation pattern using surface ECG-derived vectorcardiogram in bundle branch block. Prog Biophys Mol Biol. 2014 Aug; 115(2-3):305-13. Villongco CT, Krummen DE, Stark P, Omens JH, McCulloch AD. PMID: 25110279.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    29. Timing and magnitude of systolic stretch affect myofilament activation and mechanical work. Am J Physiol Heart Circ Physiol. 2014 Aug 01; 307(3):H353-60. Tangney JR, Campbell SG, McCulloch AD, Omens JH. PMID: 24878774.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback. J Biomech Eng. 2014 Feb; 136(2):021007. Pfeiffer ER, Tangney JR, Omens JH, McCulloch AD. PMID: 24337452.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    31. Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Hum Mol Genet. 2014 Mar 01; 23(5):1134-50. Lyon RC, Mezzano V, Wright AT, Pfeiffer E, Chuang J, Banares K, Castaneda A, Ouyang K, Cui L, Contu R, Gu Y, Evans SM, Omens JH, Peterson KL, McCulloch AD, Sheikh F. PMID: 24108106.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    32. Patient-Specific Models of Cardiac Biomechanics. J Comput Phys. 2013 Jul 01; 244:4-21. Krishnamurthy A, Villongco CT, Chuang J, Frank LR, Nigam V, Belezzuoli E, Stark P, Krummen DE, Narayan S, Omens JH, McCulloch AD, Kerckhoffs RC. PMID: 23729839.
      View in: PubMed   Mentions:
    33. Myofiber prestretch magnitude determines regional systolic function during ectopic activation in the tachycardia-induced failing canine heart. Am J Physiol Heart Circ Physiol. 2013 Jul 15; 305(2):H192-202. Howard EJ, Kerckhoffs RC, Vincent KP, Krishnamurthy A, Villongco CT, Mulligan LJ, McCulloch AD, Omens JH. PMID: 23666676.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    34. Novel role for vinculin in ventricular myocyte mechanics and dysfunction. Biophys J. 2013 Apr 02; 104(7):1623-33. Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. PMID: 23561539.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    35. Mechanical discoordination increases continuously after the onset of left bundle branch block despite constant electrical dyssynchrony in a computational model of cardiac electromechanics and growth. Europace. 2012 Nov; 14 Suppl 5:v65-v72. Kerckhoffs RC, Omens JH, McCulloch AD. PMID: 23104917.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    36. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem. 2012 Aug 24; 287(35):29273-84. Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. PMID: 22778266.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    37. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest. 2012 Apr; 122(4):1209-21. Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. PMID: 22426213.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    38. In vivo validation of longitudinal-circumferential area change ratio to estimate myofiber shortening in the heart. IEEE Trans Biomed Eng. 2012 May; 59(5):1391-7. Ashikaga H, Omens JH. PMID: 22345526.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    39. GPU acceleration of optical mapping algorithm for cardiac electrophysiology. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:1558-61. Meng P, Irturk A, Kastner R, McCulloch A, Omens J, Wright A. PMID: 23366201.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    40. A single strain-based growth law predicts concentric and eccentric cardiac growth during pressure and volume overload. Mech Res Commun. 2012 Jun 01; 42:40-50. Kerckhoffs RC, Omens J, McCulloch AD. PMID: 22639476.
      View in: PubMed   Mentions:
    41. Early postmyocardial infarction survival in Murphy Roths Large mice is mediated by attenuated apoptosis and inflammation but depends on genetic background. Exp Physiol. 2012 Jan; 97(1):102-14. Hunt DL, Campbell PH, Zambon AC, Vranizan K, Evans SM, Kuo HC, Yamaguchi KD, Omens JH, McCulloch AD. PMID: 21967898.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    42. Improvement in pump function with endocardial biventricular pacing increases with activation time at the left ventricular pacing site in failing canine hearts. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1447-55. Howard EJ, Covell JW, Mulligan LJ, McCulloch AD, Omens JH, Kerckhoffs RC. PMID: 21784986.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    43. Patient-specific modeling of dyssynchronous heart failure: a case study. Prog Biophys Mol Biol. 2011 Oct; 107(1):147-55. Aguado-Sierra J, Krishnamurthy A, Villongco C, Chuang J, Howard E, Gonzales MJ, Omens J, Krummen DE, Narayan S, Kerckhoffs RC, McCulloch AD. PMID: 21763714.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    44. Increased infarct wall thickness by a bio-inert material is insufficient to prevent negative left ventricular remodeling after myocardial infarction. PLoS One. 2011; 6(6):e21571. Rane AA, Chuang JS, Shah A, Hu DP, Dalton ND, Gu Y, Peterson KL, Omens JH, Christman KL. PMID: 21731777.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    45. Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI. Magn Reson Med. 2010 Nov; 64(5):1281-8. Chuang JS, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. PMID: 20981782.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    46. Ventricular dilation and electrical dyssynchrony synergistically increase regional mechanical nonuniformity but not mechanical dyssynchrony: a computational model. Circ Heart Fail. 2010 Jul; 3(4):528-36. Kerckhoffs RC, Omens JH, McCulloch AD, Mulligan LJ. PMID: 20466849.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    47. Cardiac myocyte force development during differentiation and maturation. Ann N Y Acad Sci. 2010 Feb; 1188:121-7. Jacot JG, Kita-Matsuo H, Wei KA, Chen HS, Omens JH, Mercola M, McCulloch AD. PMID: 20201894.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    48. Use of Larger Species such as Dog and Pig as Model Systems to Study Cardiac Disease. Drug Discov Today Dis Models. 2009 Oct 01; 5(3):195-200. Coppola BA, Omens JH. PMID: 20161184.
      View in: PubMed   Mentions:
    49. Hypertrophic gene expression induced by chronic stretch of excised mouse heart muscle. Mol Cell Biomech. 2009 Sep; 6(3):145-59. Raskin AM, Hoshijima M, Swanson E, McCulloch AD, Omens JH. PMID: 19670825.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    50. Effect of transmurally heterogeneous myocyte excitation-contraction coupling on canine left ventricular electromechanics. Exp Physiol. 2009 May; 94(5):541-52. Campbell SG, Howard E, Aguado-Sierra J, Coppola BA, Omens JH, Mulligan LJ, McCulloch AD, Kerckhoffs RC. PMID: 19251984.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    51. Transmural myocardial mechanics during isovolumic contraction. JACC Cardiovasc Imaging. 2009 Feb; 2(2):202-11. Ashikaga H, van der Spoel TI, Coppola BA, Omens JH. PMID: 19356557.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    52. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. PMID: 19033658.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    53. Role of tissue structure on ventricular wall mechanics. Mol Cell Biomech. 2008 Sep; 5(3):183-96. Coppola BA, Omens JH. PMID: 18751527.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    54. Effects of biventricular pacing and scar size in a computational model of the failing heart with left bundle branch block. Med Image Anal. 2009 Apr; 13(2):362-9. Kerckhoffs RC, McCulloch AD, Omens JH, Mulligan LJ. PMID: 18675578.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    55. Computational modeling for bedside application. Heart Fail Clin. 2008 Jul; 4(3):371-8. Kerckhoffs RC, Narayan SM, Omens JH, Mulligan LJ, McCulloch AD. PMID: 18598988.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    56. Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes. Biophys J. 2008 Oct; 95(7):3479-87. Jacot JG, McCulloch AD, Omens JH. PMID: 18586852.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    57. Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H610-8. Ashikaga H, Coppola BA, Yamazaki KG, Villarreal FJ, Omens JH, Covell JW. PMID: 18515651.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    58. Cardiac resynchronization: insight from experimental and computational models. Prog Biophys Mol Biol. 2008 Jun-Jul; 97(2-3):543-61. Kerckhoffs RC, Lumens J, Vernooy K, Omens JH, Mulligan LJ, Delhaas T, Arts T, McCulloch AD, Prinzen FW. PMID: 18417196.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    59. Effects of biglycan deficiency on myocardial infarct structure and mechanics. Mol Cell Biomech. 2008 Mar; 5(1):27-35. Campbell PH, Hunt DL, Jones Y, Harwood F, Amiel D, Omens JH, McCulloch AD. PMID: 18524244.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    60. Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technology. Ann N Y Acad Sci. 2008 Mar; 1123:169-77. Feala JD, Omens JH, Paternostro G, McCulloch AD. PMID: 18375589.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    61. Asynchrony of ventricular activation affects magnitude and timing of fiber stretch in late-activated regions of the canine heart. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H754-61. Coppola BA, Covell JW, McCulloch AD, Omens JH. PMID: 17449547.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    62. High-resolution longitudinal MRI of the transition to heart failure. Magn Reson Med. 2007 Apr; 57(4):714-20. Costandi PN, McCulloch AD, Omens JH, Frank LR. PMID: 17390366.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    63. Transmural dispersion of myofiber mechanics: implications for electrical heterogeneity in vivo. J Am Coll Cardiol. 2007 Feb 27; 49(8):909-16. Ashikaga H, Coppola BA, Hopenfeld B, Leifer ES, McVeigh ER, Omens JH. PMID: 17320750.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    64. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H2944-51. Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I, Chun J, Brown JH. PMID: 17293497.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    65. Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation. Ann Biomed Eng. 2007 Jan; 35(1):1-18. Kerckhoffs RC, Neal ML, Gu Q, Bassingthwaighte JB, Omens JH, McCulloch AD. PMID: 17111210.
      View in: PubMed   Mentions: 82     Fields:    Translation:Animals
    66. Role of diastolic properties in the transition to failure in a mouse model of the cardiac dilatation. Am J Physiol Heart Circ Physiol. 2006 Dec; 291(6):H2971-9. Costandi PN, Frank LR, McCulloch AD, Omens JH. PMID: 16861693.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    67. Myocyte shearing, myocardial sheets, and microtubules. Circ Res. 2006 Jan 06; 98(1):1-3. McCulloch AD, Omens JH. PMID: 16397149.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    68. Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear. Cell Biochem Biophys. 2006; 46(2):113-22. Lorenzen-Schmidt I, Schmid-Schönbein GW, Giles WR, McCulloch AD, Chien S, Omens JH. PMID: 17012753.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    69. Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. J Mol Cell Cardiol. 2005 Aug; 39(2):241-50. Lorenzen-Schmidt I, Stuyvers BD, ter Keurs HE, Date MO, Hoshijima M, Chien KR, McCulloch AD, Omens JH. PMID: 15978612.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    70. Deficiency of actinin-associated LIM protein alters regional right ventricular function and hypertrophic remodeling. Ann Biomed Eng. 2005 Jul; 33(7):888-96. Lorenzen-Schmidt I, McCulloch AD, Omens JH. PMID: 16060528.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    71. A role for decorin in the remodeling of myocardial infarction. Matrix Biol. 2005 Jun; 24(4):313-24. Weis SM, Zimmerman SD, Shah M, Covell JW, Omens JH, Ross J, Dalton N, Jones Y, Reed CC, Iozzo RV, McCulloch AD. PMID: 15949932.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    72. Etanercept or intravenous immunoglobulin attenuates expression of genes involved in post-myocardial infarction remodeling. Cardiovasc Res. 2005 Jul 01; 67(1):106-15. Gurantz D, Yndestad A, Halvorsen B, Lunde OV, Omens JH, Ueland T, Aukrust P, Moore CD, Kjekshus J, Greenberg BH. PMID: 15949474.
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    73. Diastolic dysfunction in volume-overload hypertrophy is associated with abnormal shearing of myolaminar sheets. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2603-10. Ashikaga H, Covell JW, Omens JH. PMID: 15708954.
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    74. Time-dependent remodeling of transmural architecture underlying abnormal ventricular geometry in chronic volume overload heart failure. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1994-2002. Ashikaga H, Omens JH, Covell JW. PMID: 15242833.
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    75. Early degradation and serum appearance of type I collagen fragments after myocardial infarction. J Mol Cell Cardiol. 2004 Apr; 36(4):597-601. Villarreal F, Omens J, Dillmann W, Risteli J, Nguyen J, Covell J. PMID: 15081319.
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    76. Transmural mechanics at left ventricular epicardial pacing site. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2401-7. Ashikaga H, Omens JH, Ingels NB, Covell JW. PMID: 14751858.
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    77. Transmural left ventricular mechanics underlying torsional recoil during relaxation. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H640-7. Ashikaga H, Criscione JC, Omens JH, Covell JW, Ingels NB. PMID: 14551052.
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    78. Early short-term treatment with doxycycline modulates postinfarction left ventricular remodeling. Circulation. 2003 Sep 23; 108(12):1487-92. Villarreal FJ, Griffin M, Omens J, Dillmann W, Nguyen J, Covell J. PMID: 12952845.
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    79. Ventricular filling slows epicardial conduction and increases action potential duration in an optical mapping study of the isolated rabbit heart. J Cardiovasc Electrophysiol. 2003 Jul; 14(7):739-49. Sung D, Mills RW, Schettler J, Narayan SM, Omens JH, McCulloch AD. PMID: 12930255.
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    80. Complex distributions of residual stress and strain in the mouse left ventricle: experimental and theoretical models. Biomech Model Mechanobiol. 2003 Apr; 1(4):267-77. Omens JH, McCulloch AD, Criscione JC. PMID: 14586695.
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    81. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng. 2003 Mar 05; 81(5):578-87. Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. PMID: 12514807.
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    82. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002 Dec 27; 111(7):943-55. Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR. PMID: 12507422.
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    83. Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy. Am J Physiol Heart Circ Physiol. 2003 Apr; 284(4):H1277-84. Herrmann KL, McCulloch AD, Omens JH. PMID: 12595292.
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    84. Muscle LIM protein deficiency leads to alterations in passive ventricular mechanics. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H680-7. Omens JH, Usyk TP, Li Z, McCulloch AD. PMID: 11788418.
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    85. Regional septal dysfunction in a three-dimensional computational model of focal myofiber disarray. Am J Physiol Heart Circ Physiol. 2001 Aug; 281(2):H506-14. Usyk TP, Omens JH, McCulloch AD. PMID: 11454551.
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    86. Transmural distribution of three-dimensional systolic strains in stunned myocardium. Circulation. 2001 Jul 17; 104(3):336-41. Mazhari R, Omens JH, Pavelec RS, Covell JW, McCulloch AD. PMID: 11457754.
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    87. Age-associated cardiac dysfunction in Drosophila melanogaster. Circ Res. 2001 May 25; 88(10):1053-8. Paternostro G, Vignola C, Bartsch DU, Omens JH, McCulloch AD, Reed JC. PMID: 11375275.
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    88. Myocardial mechanics and collagen structure in the osteogenesis imperfecta murine (oim). Circ Res. 2000 Oct 13; 87(8):663-9. Weis SM, Emery JL, Becker KD, McBride DJ, Omens JH, McCulloch AD. PMID: 11029401.
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    89. Model-based analysis of optically mapped epicardial activation patterns and conduction velocity. Ann Biomed Eng. 2000 Sep; 28(9):1085-92. Sung D, Omens JH, McCulloch AD. PMID: 11132192.
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    90. Structural basis of regional dysfunction in acutely ischemic myocardium. Cardiovasc Res. 2000 Aug; 47(2):284-93. Mazhari R, Omens JH, Covell JW, McCulloch AD. PMID: 10946065.
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    91. Regional dysfunction correlates with myofiber disarray in transgenic mice with ventricular expression of ras. Am J Physiol Heart Circ Physiol. 2000 Mar; 278(3):H898-906. Karlon WJ, McCulloch AD, Covell JW, Hunter JJ, Omens JH. PMID: 10710359.
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    92. Structural and mechanical factors influencing infarct scar collagen organization. Am J Physiol Heart Circ Physiol. 2000 Jan; 278(1):H194-200. Zimmerman SD, Karlon WJ, Holmes JW, Omens JH, Covell JW. PMID: 10644599.
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    93. Measurement of orientation and distribution of cellular alignment and cytoskeletal organization. Ann Biomed Eng. 1999 Nov-Dec; 27(6):712-20. Karlon WJ, Hsu PP, Li S, Chien S, McCulloch AD, Omens JH. PMID: 10625144.
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    94. Nicotine-modified postinfarction left ventricular remodeling. Am J Physiol. 1999 03; 276(3):H1103-6. Villarreal FJ, Hong D, Omens J. PMID: 10070098.
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    95. Residual strain in ischemic ventricular myocardium. J Biomech Eng. 1998 Dec; 120(6):710-4. Summerour SR, Emery JL, Fazeli B, Omens JH, McCulloch AD. PMID: 10412453.
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    96. Left ventricular geometric remodeling and residual stress in the rat heart. J Biomech Eng. 1998 Dec; 120(6):715-9. Omens JH, Vaplon SM, Fazeli B, McCulloch AD. PMID: 10412454.
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    97. Automated measurement of myofiber disarray in transgenic mice with ventricular expression of ras. Anat Rec. 1998 12; 252(4):612-25. Karlon WJ, Covell JW, McCulloch AD, Hunter JJ, Omens JH. PMID: 9845212.
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    98. Regional myocardial perfusion and mechanics: a model-based method of analysis. Ann Biomed Eng. 1998 Sep-Oct; 26(5):743-55. Mazhari R, Omens JH, Waldman LK, McCulloch AD. PMID: 9779946.
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    99. Flow-function relations during graded coronary occlusions in the dog: effects of transmural location and segment orientation. Cardiovasc Res. 1998 Mar; 37(3):636-45. McCulloch AD, Sung D, Wilson JM, Pavelec RS, Omens JH. PMID: 9659447.
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    100. Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70. J Clin Invest. 1998 Feb 15; 101(4):855-62. Trost SU, Omens JH, Karlon WJ, Meyer M, Mestril R, Covell JW, Dillmann WH. PMID: 9466981.
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    101. Stress and strain as regulators of myocardial growth. Prog Biophys Mol Biol. 1998; 69(2-3):559-72. Omens JH. PMID: 9785956.
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    102. Three-dimensional residual strain in midanterior canine left ventricle. Am J Physiol. 1997 10; 273(4):H1968-76. Costa KD, May-Newman K, Farr D, O'Dell WG, McCulloch AD, Omens JH. PMID: 9362268.
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    103. Mechanical regulation of myocardial growth during volume-overload hypertrophy in the rat. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1198-204. Emery JL, Omens JH. PMID: 9321807.
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    104. Biaxial mechanics of the passively overstretched left ventricle. Am J Physiol. 1997 May; 272(5 Pt 2):H2299-305. Emery JL, Omens JH, McCulloch AD. PMID: 9176298.
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    105. Strain softening in rat left ventricular myocardium. J Biomech Eng. 1997 Feb; 119(1):6-12. Emery JL, Omens JH, McCulloch AD. PMID: 9083843.
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    106. Relationship between passive tissue strain and collagen uncoiling during healing of infarcted myocardium. Cardiovasc Res. 1997 Feb; 33(2):351-8. Omens JH, Miller TR, Covell JW. PMID: 9074699.
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    107. Comparison of two techniques for measuring two-dimensional strain in rat left ventricles. Am J Physiol. 1996 Sep; 271(3 Pt 2):H1256-61. Omens JH, Farr DD, McCulloch AD, Waldman LK. PMID: 8853366.
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    108. Transmural changes in stress-free myocyte morphology during pressure overload hypertrophy in the rat. J Mol Cell Cardiol. 1996 Sep; 28(9):1975-83. Omens JH, Rodriguez EK, McCulloch AD. PMID: 8899556.
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    109. Left ventricular perimysial collagen fibers uncoil rather than stretch during diastolic filling. Basic Res Cardiol. 1996 Mar-Apr; 91(2):111-22. MacKenna DA, Omens JH, Covell JW. PMID: 8740527.
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    110. Transmural distribution of capillary morphology as a function of coronary perfusion pressure in the resting canine heart. Microvasc Res. 1995 Nov; 50(3):381-96. May-Newman K, Mathieu-Costello O, Omens JH, Klumb K, McCulloch AD. PMID: 8583952.
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    111. Effects of pressure overload on the passive mechanics of the rat left ventricle. Ann Biomed Eng. 1995 Mar-Apr; 23(2):152-63. Omens JH, Milkes DE, Covell JW. PMID: 7605052.
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    112. Myocardial remodeling in hypertensive Ren-2 transgenic rats. Hypertension. 1995 Jan; 25(1):98-104. Villarreal FJ, MacKenna DA, Omens JH, Dillmann WH. PMID: 7843762.
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    113. Three-dimensional transmural mechanical interaction between the coronary vasculature and passive myocardium in the dog. Circ Res. 1994 Jun; 74(6):1166-78. May-Newman K, Omens JH, Pavelec RS, McCulloch AD. PMID: 8187283.
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    114. Contribution of collagen matrix to passive left ventricular mechanics in isolated rat hearts. Am J Physiol. 1994 Mar; 266(3 Pt 2):H1007-18. MacKenna DA, Omens JH, McCulloch AD, Covell JW. PMID: 8160804.
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    115. Passive ventricular mechanics in tight-skin mice. Am J Physiol. 1994 Mar; 266(3 Pt 2):H1169-76. Omens JH, Rockman HA, Covell JW. PMID: 8160820.
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    116. Measurement of strain and analysis of stress in resting rat left ventricular myocardium. J Biomech. 1993 Jun; 26(6):665-76. Omens JH, MacKenna DA, McCulloch AD. PMID: 8514812.
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    117. Effect of residual stress on transmural sarcomere length distributions in rat left ventricle. Am J Physiol. 1993 Apr; 264(4 Pt 2):H1048-56. Rodriguez EK, Omens JH, Waldman LK, McCulloch AD. PMID: 8476082.
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    118. Transmural distribution of myocardial tissue growth induced by volume-overload hypertrophy in the dog. Circulation. 1991 Sep; 84(3):1235-45. Omens JH, Covell JW. PMID: 1832093.
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    119. Transmural distribution of three-dimensional strain in the isolated arrested canine left ventricle. Am J Physiol. 1991 Sep; 261(3 Pt 2):H918-28. Omens JH, May KD, McCulloch AD. PMID: 1887936.
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    120. Non-homogeneous analysis of three-dimensional transmural finite deformation in canine ventricular myocardium. J Biomech. 1991; 24(7):539-48. McCulloch AD, Omens JH. PMID: 1880138.
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    121. Residual strain in rat left ventricle. Circ Res. 1990 Jan; 66(1):37-45. Omens JH, Fung YC. PMID: 2295143.
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