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Jeffrey Omens

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0613-J
La Jolla CA 92093
Phone858-534-8102
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    Collapse Research 
    Collapse Research Activities and Funding
    The Cardiac Atlas Project
    NIH/NHLBI R01HL121754Jan 1, 2014 - Dec 31, 2017
    Role: Principal Investigator
    Cardiomyocyte mechanotransduction through the integrin complex
    NIH/NHLBI R01HL103566Jul 15, 2010 - Apr 30, 2015
    Role: Principal Investigator
    MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    NIH/NHLBI R01HL064321Feb 1, 2001 - Jan 31, 2006
    Role: Principal Investigator
    STRESS AND STRAIN AS STIMULI FOR MYOCARDIAL GROWTH
    NIH/NHLBI R01HL054686Aug 1, 1996 - Jun 30, 2001
    Role: Principal Investigator
    STRESS AND STRAIN AS STIMULI FOR MYOCARDIAL GROWTH
    NIH/NHLBI R29HL054686Aug 1, 1996 - Jun 30, 2000
    Role: Principal Investigator
    NATIONAL BIOMEDICAL COMPUTATION RESOURCE
    NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
    Role: Co-Investigator
    VENTRICULAR TRANSMURAL DEFORMATION IN VOLUME OVERLOAD
    NIH/NHLBI F32HL008153Mar 27, 1990
    Role: Principal Investigator
    Transmural Deformation
    NIH/NHLBI R01HL032583Jul 1, 1984 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lewalle A, Land S, Carruth E, Frank LR, Lamata P, Omens J, McCulloch AD, Niederer SA, Smith NP. Decreasing Compensatory Ability of Concentric Ventricular Hypertrophy in Aortic-Banded Rat Hearts. Front Physiol. 2018; 9:37. PMID: 29527171.
      View in: PubMed
    2. Gilbert K, Forsch N, Hegde S, Mauger C, Omens J, Perry JC, Pontré B, Suinesiaputra A, Young AA, McCulloch AD. Atlas-Based Computational Analysis of Heart Shape and Function in Congenital Heart Disease. J Cardiovasc Transl Res. 2018 Jan 02. PMID: 29294215.
      View in: PubMed
    3. Tan PM, Buchholz KS, Omens J, McCulloch AD, Saucerman JJ. Predictive model identifies key network regulators of cardiomyocyte mechano-signaling. PLoS Comput Biol. 2017 Nov; 13(11):e1005854. PMID: 29131824.
      View in: PubMed
    4. Dewan S, Krishnamurthy A, Kole D, Conca G, Kerckhoffs R, Puchalski MD, Omens J, Sun H, Nigam V, McCulloch AD. Model of Human Fetal Growth in Hypoplastic Left Heart Syndrome: Reduced Ventricular Growth Due to Decreased Ventricular Filling and Altered Shape. Front Pediatr. 2017; 5:25. PMID: 28275592.
      View in: PubMed
    5. Bradford WH, Omens J, Sheikh F. Vinculin at the heart of aging. Ann Transl Med. 2017 Feb; 5(3):62. PMID: 28251141.
      View in: PubMed
    6. Villongco CT, Krummen DE, Omens J, McCulloch AD. Non-invasive, model-based measures of ventricular electrical dyssynchrony for predicting CRT outcomes. Europace. 2016 Dec; 18(suppl 4):iv104-iv112. PMID: 28011837.
      View in: PubMed
    7. Carruth ED, McCulloch AD, Omens J. Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload. Prog Biophys Mol Biol. 2016 Dec; 122(3):215-226. PMID: 27845176.
      View in: PubMed
    8. McClymont D, Teh I, Carruth E, Omens J, McCulloch A, Whittington HJ, Kohl P, Grau V, Schneider JE. Evaluation of non-Gaussian diffusion in cardiac MRI. Magn Reson Med. 2017 Sep; 78(3):1174-1186. PMID: 27670633.
      View in: PubMed
    9. Farrar G, Suinesiaputra A, Gilbert K, Perry JC, Hegde S, Marsden A, Young AA, Omens J, McCulloch AD. Atlas-Based Ventricular Shape Analysis for Understanding Congenital Heart Disease. Prog Pediatr Cardiol. 2016 Dec; 43:61-69. PMID: 28082823.
      View in: PubMed
    10. Gilbert K, Farrar G, Cowan B, Suinesiaputra A, Occleshaw C, Pontre B, Perry J, Hegde S, Omens J, McCulloch A, Young A. Improving assessment of congenital heart disease through rapid patient specific modeling. Conf Proc IEEE Eng Med Biol Soc. 2016 08; 2016:1228-1231. PMID: 28268546.
      View in: PubMed
    11. Wassenaar JW, Gaetani R, Garcia JJ, Braden RL, Luo CG, Huang D, DeMaria AN, Omens J, Christman KL. Evidence for Mechanisms Underlying the Functional Benefits of a Myocardial Matrix Hydrogel for Post-MI Treatment. J Am Coll Cardiol. 2016 Mar 08; 67(9):1074-86. PMID: 26940929; PMCID: PMC4779189 [Available on 03/08/17].
    12. Krummen DE, Hayase J, Vampola SP, Ho G, Schricker AA, Lalani GG, Baykaner T, Coe TM, Clopton P, Rappel WJ, Omens J, Narayan SM. Modifying Ventricular Fibrillation by Targeted Rotor Substrate Ablation: Proof-of-Concept from Experimental Studies to Clinical VF. J Cardiovasc Electrophysiol. 2015 Oct; 26(10):1117-26. PMID: 26179310; PMCID: PMC4826737.
    13. Vincent KP, Gonzales MJ, Gillette AK, Villongco CT, Pezzuto S, Omens J, Holst MJ, McCulloch AD. High-order finite element methods for cardiac monodomain simulations. Front Physiol. 2015; 6:217. PMID: 26300783; PMCID: PMC4525671.
    14. Gilbert K, Farrar G, Cowan BR, Suinesiaputra A, Occleshaw C, Pontre B, Perry J, Hegde S, Marsden A, Omens J, McCulloch A, Young AA. Creating shape templates for patient specific biventricular modeling in congenital heart disease. Conf Proc IEEE Eng Med Biol Soc. 2015 08; 2015:679-82. PMID: 26736353.
      View in: PubMed
    15. Lyon RC, Zanella F, Omens J, Sheikh F. Mechanotransduction in cardiac hypertrophy and failure. Circ Res. 2015 Apr 10; 116(8):1462-1476. PMID: 25858069; PMCID: PMC4394185.
    16. Krishnamurthy A, Villongco C, Beck A, Omens J, McCulloch A. Left Ventricular Diastolic and Systolic Material Property Estimation from Image Data: LV Mechanics Challenge. Stat Atlases Comput Models Heart. 2015 Jan; 8896:63-73. PMID: 25729778.
      View in: PubMed
    17. Pfeiffer ER, Wright AT, Edwards AG, Stowe JC, McNall K, Tan J, Niesman I, Patel HH, Roth DM, Omens J, McCulloch AD. Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing. J Mol Cell Cardiol. 2014 Nov; 76:265-74. PMID: 25257915; PMCID: PMC4250283.
    18. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens J, Heller Brown J, Bers DM, McCulloch AD. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. PMID: 25236710; PMCID: PMC4301603.
    19. Villongco CT, Krummen DE, Stark P, Omens J, McCulloch AD. Patient-specific modeling of ventricular activation pattern using surface ECG-derived vectorcardiogram in bundle branch block. Prog Biophys Mol Biol. 2014 Aug; 115(2-3):305-13. PMID: 25110279; PMCID: PMC4254140.
    20. Tangney JR, Campbell SG, McCulloch AD, Omens J. Timing and magnitude of systolic stretch affect myofilament activation and mechanical work. Am J Physiol Heart Circ Physiol. 2014 Aug 01; 307(3):H353-60. PMID: 24878774; PMCID: PMC4182292.
    21. Pfeiffer ER, Tangney JR, Omens J, McCulloch AD. Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback. J Biomech Eng. 2014 Feb; 136(2):021007. PMID: 24337452; PMCID: PMC4023651.
    22. Lyon RC, Mezzano V, Wright AT, Pfeiffer E, Chuang J, Banares K, Castaneda A, Ouyang K, Cui L, Contu R, Gu Y, Evans SM, Omens J, Peterson KL, McCulloch AD, Sheikh F. Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Hum Mol Genet. 2014 Mar 01; 23(5):1134-50. PMID: 24108106; PMCID: PMC3919010.
    23. Krishnamurthy A, Villongco CT, Chuang J, Frank LR, Nigam V, Belezzuoli E, Stark P, Krummen DE, Narayan S, Omens J, McCulloch AD, Kerckhoffs RC. Patient-Specific Models of Cardiac Biomechanics. J Comput Phys. 2013 Jul 01; 244:4-21. PMID: 23729839.
      View in: PubMed
    24. Howard EJ, Kerckhoffs RC, Vincent KP, Krishnamurthy A, Villongco CT, Mulligan LJ, McCulloch AD, Omens J. Myofiber prestretch magnitude determines regional systolic function during ectopic activation in the tachycardia-induced failing canine heart. Am J Physiol Heart Circ Physiol. 2013 Jul 15; 305(2):H192-202. PMID: 23666676; PMCID: PMC3726954.
    25. Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens J. Novel role for vinculin in ventricular myocyte mechanics and dysfunction. Biophys J. 2013 Apr 02; 104(7):1623-33. PMID: 23561539; PMCID: PMC3617425.
    26. Kerckhoffs RC, Omens J, McCulloch AD. Mechanical discoordination increases continuously after the onset of left bundle branch block despite constant electrical dyssynchrony in a computational model of cardiac electromechanics and growth. Europace. 2012 Nov; 14 Suppl 5:v65-v72. PMID: 23104917; PMCID: PMC3482618.
    27. Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens J, Sheikh F. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem. 2012 Aug 24; 287(35):29273-84. PMID: 22778266; PMCID: PMC3436149.
    28. Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens J, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest. 2012 Apr; 122(4):1209-21. PMID: 22426213; PMCID: PMC3314469.
    29. Ashikaga H, Omens J. In vivo validation of longitudinal-circumferential area change ratio to estimate myofiber shortening in the heart. IEEE Trans Biomed Eng. 2012 May; 59(5):1391-7. PMID: 22345526; PMCID: PMC4247784.
    30. Meng P, Irturk A, Kastner R, McCulloch A, Omens J, Wright A. GPU acceleration of optical mapping algorithm for cardiac electrophysiology. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:1558-61. PMID: 23366201; PMCID: PMC3651586.
    31. Kerckhoffs RC, Omens J, McCulloch AD. A single strain-based growth law predicts concentric and eccentric cardiac growth during pressure and volume overload. Mech Res Commun. 2012 Jun 01; 42:40-50. PMID: 22639476.
      View in: PubMed
    32. Hunt DL, Campbell PH, Zambon AC, Vranizan K, Evans SM, Kuo HC, Yamaguchi KD, Omens J, McCulloch AD. Early postmyocardial infarction survival in Murphy Roths Large mice is mediated by attenuated apoptosis and inflammation but depends on genetic background. Exp Physiol. 2012 Jan; 97(1):102-14. PMID: 21967898; PMCID: PMC3253239.
    33. Howard EJ, Covell JW, Mulligan LJ, McCulloch AD, Omens J, Kerckhoffs RC. Improvement in pump function with endocardial biventricular pacing increases with activation time at the left ventricular pacing site in failing canine hearts. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1447-55. PMID: 21784986; PMCID: PMC3197362.
    34. Aguado-Sierra J, Krishnamurthy A, Villongco C, Chuang J, Howard E, Gonzales MJ, Omens J, Krummen DE, Narayan S, Kerckhoffs RC, McCulloch AD. Patient-specific modeling of dyssynchronous heart failure: a case study. Prog Biophys Mol Biol. 2011 Oct; 107(1):147-55. PMID: 21763714; PMCID: PMC3190065.
    35. Rane AA, Chuang JS, Shah A, Hu DP, Dalton ND, Gu Y, Peterson KL, Omens J, Christman KL. Increased infarct wall thickness by a bio-inert material is insufficient to prevent negative left ventricular remodeling after myocardial infarction. PLoS One. 2011; 6(6):e21571. PMID: 21731777; PMCID: PMC3121880.
    36. Chuang JS, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens J. Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI. Magn Reson Med. 2010 Nov; 64(5):1281-8. PMID: 20981782; PMCID: PMC3272305.
    37. Kerckhoffs RC, Omens J, McCulloch AD, Mulligan LJ. Ventricular dilation and electrical dyssynchrony synergistically increase regional mechanical nonuniformity but not mechanical dyssynchrony: a computational model. Circ Heart Fail. 2010 Jul; 3(4):528-36. PMID: 20466849; PMCID: PMC3050711.
    38. Jacot JG, Kita-Matsuo H, Wei KA, Chen HS, Omens J, Mercola M, McCulloch AD. Cardiac myocyte force development during differentiation and maturation. Ann N Y Acad Sci. 2010 Feb; 1188:121-7. PMID: 20201894; PMCID: PMC2920416.
    39. Coppola BA, Omens J. Use of Larger Species such as Dog and Pig as Model Systems to Study Cardiac Disease. Drug Discov Today Dis Models. 2009 Oct 01; 5(3):195-200. PMID: 20161184.
      View in: PubMed
    40. Raskin AM, Hoshijima M, Swanson E, McCulloch AD, Omens J. Hypertrophic gene expression induced by chronic stretch of excised mouse heart muscle. Mol Cell Biomech. 2009 Sep; 6(3):145-59. PMID: 19670825; PMCID: PMC3272304.
    41. Campbell SG, Howard E, Aguado-Sierra J, Coppola BA, Omens J, Mulligan LJ, McCulloch AD, Kerckhoffs RC. Effect of transmurally heterogeneous myocyte excitation-contraction coupling on canine left ventricular electromechanics. Exp Physiol. 2009 May; 94(5):541-52. PMID: 19251984; PMCID: PMC2744637.
    42. Ashikaga H, van der Spoel TI, Coppola BA, Omens J. Transmural myocardial mechanics during isovolumic contraction. JACC Cardiovasc Imaging. 2009 Feb; 2(2):202-11. PMID: 19356557; PMCID: PMC2821599.
    43. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens J, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. PMID: 19033658; PMCID: PMC2575833.
    44. Coppola BA, Omens J. Role of tissue structure on ventricular wall mechanics. Mol Cell Biomech. 2008 Sep; 5(3):183-96. PMID: 18751527; PMCID: PMC2698048.
    45. Kerckhoffs RC, McCulloch AD, Omens J, Mulligan LJ. Effects of biventricular pacing and scar size in a computational model of the failing heart with left bundle branch block. Med Image Anal. 2009 Apr; 13(2):362-9. PMID: 18675578; PMCID: PMC2796510.
    46. Kerckhoffs RC, Narayan SM, Omens J, Mulligan LJ, McCulloch AD. Computational modeling for bedside application. Heart Fail Clin. 2008 Jul; 4(3):371-8. PMID: 18598988; PMCID: PMC2518746.
    47. Jacot JG, McCulloch AD, Omens J. Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes. Biophys J. 2008 Oct; 95(7):3479-87. PMID: 18586852; PMCID: PMC2547444.
    48. Ashikaga H, Coppola BA, Yamazaki KG, Villarreal FJ, Omens J, Covell JW. Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H610-8. PMID: 18515651; PMCID: PMC2519196.
    49. Kerckhoffs RC, Lumens J, Vernooy K, Omens J, Mulligan LJ, Delhaas T, Arts T, McCulloch AD, Prinzen FW. Cardiac resynchronization: insight from experimental and computational models. Prog Biophys Mol Biol. 2008 Jun-Jul; 97(2-3):543-61. PMID: 18417196; PMCID: PMC2676869.
    50. Campbell PH, Hunt DL, Jones Y, Harwood F, Amiel D, Omens J, McCulloch AD. Effects of biglycan deficiency on myocardial infarct structure and mechanics. Mol Cell Biomech. 2008 Mar; 5(1):27-35. PMID: 18524244; PMCID: PMC2679639.
    51. Feala JD, Omens J, Paternostro G, McCulloch AD. Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technology. Ann N Y Acad Sci. 2008 Mar; 1123:169-77. PMID: 18375589.
      View in: PubMed
    52. Coppola BA, Covell JW, McCulloch AD, Omens J. Asynchrony of ventricular activation affects magnitude and timing of fiber stretch in late-activated regions of the canine heart. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H754-61. PMID: 17449547; PMCID: PMC3328414.
    53. Costandi PN, McCulloch AD, Omens J, Frank LR. High-resolution longitudinal MRI of the transition to heart failure. Magn Reson Med. 2007 Apr; 57(4):714-20. PMID: 17390366; PMCID: PMC4482467.
    54. Ashikaga H, Coppola BA, Hopenfeld B, Leifer ES, McVeigh ER, Omens J. Transmural dispersion of myofiber mechanics: implications for electrical heterogeneity in vivo. J Am Coll Cardiol. 2007 Feb 27; 49(8):909-16. PMID: 17320750.
      View in: PubMed
    55. Means CK, Xiao CY, Li Z, Zhang T, Omens J, Ishii I, Chun J, Brown JH. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H2944-51. PMID: 17293497.
      View in: PubMed
    56. Kerckhoffs RC, Neal ML, Gu Q, Bassingthwaighte JB, Omens J, McCulloch AD. Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation. Ann Biomed Eng. 2007 Jan; 35(1):1-18. PMID: 17111210; PMCID: PMC2872168.
    57. Costandi PN, Frank LR, McCulloch AD, Omens J. Role of diastolic properties in the transition to failure in a mouse model of the cardiac dilatation. Am J Physiol Heart Circ Physiol. 2006 Dec; 291(6):H2971-9. PMID: 16861693; PMCID: PMC3334322.
    58. McCulloch AD, Omens J. Myocyte shearing, myocardial sheets, and microtubules. Circ Res. 2006 Jan 06; 98(1):1-3. PMID: 16397149.
      View in: PubMed
    59. Lorenzen-Schmidt I, Schmid-Schönbein GW, Giles WR, McCulloch AD, Chien S, Omens J. Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear. Cell Biochem Biophys. 2006; 46(2):113-22. PMID: 17012753; PMCID: PMC3310206.
    60. Lorenzen-Schmidt I, Stuyvers BD, ter Keurs HE, Date MO, Hoshijima M, Chien KR, McCulloch AD, Omens J. Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. J Mol Cell Cardiol. 2005 Aug; 39(2):241-50. PMID: 15978612; PMCID: PMC4484861.
    61. Lorenzen-Schmidt I, McCulloch AD, Omens J. Deficiency of actinin-associated LIM protein alters regional right ventricular function and hypertrophic remodeling. Ann Biomed Eng. 2005 Jul; 33(7):888-96. PMID: 16060528; PMCID: PMC4482468.
    62. Weis SM, Zimmerman SD, Shah M, Covell JW, Omens J, Ross J, Dalton N, Jones Y, Reed CC, Iozzo RV, McCulloch AD. A role for decorin in the remodeling of myocardial infarction. Matrix Biol. 2005 Jun; 24(4):313-24. PMID: 15949932.
      View in: PubMed
    63. Gurantz D, Yndestad A, Halvorsen B, Lunde OV, Omens J, Ueland T, Aukrust P, Moore CD, Kjekshus J, Greenberg BH. Etanercept or intravenous immunoglobulin attenuates expression of genes involved in post-myocardial infarction remodeling. Cardiovasc Res. 2005 Jul 01; 67(1):106-15. PMID: 15949474.
      View in: PubMed
    64. Ashikaga H, Covell JW, Omens J. Diastolic dysfunction in volume-overload hypertrophy is associated with abnormal shearing of myolaminar sheets. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2603-10. PMID: 15708954; PMCID: PMC2822838.
    65. Ashikaga H, Omens J, Covell JW. Time-dependent remodeling of transmural architecture underlying abnormal ventricular geometry in chronic volume overload heart failure. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1994-2002. PMID: 15242833; PMCID: PMC2842928.
    66. Villarreal F, Omens J, Dillmann W, Risteli J, Nguyen J, Covell J. Early degradation and serum appearance of type I collagen fragments after myocardial infarction. J Mol Cell Cardiol. 2004 Apr; 36(4):597-601. PMID: 15081319.
      View in: PubMed
    67. Ashikaga H, Omens J, Ingels NB, Covell JW. Transmural mechanics at left ventricular epicardial pacing site. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2401-7. PMID: 14751858; PMCID: PMC2965026.
    68. Ashikaga H, Criscione JC, Omens J, Covell JW, Ingels NB. Transmural left ventricular mechanics underlying torsional recoil during relaxation. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H640-7. PMID: 14551052; PMCID: PMC2954110.
    69. Villarreal FJ, Griffin M, Omens J, Dillmann W, Nguyen J, Covell J. Early short-term treatment with doxycycline modulates postinfarction left ventricular remodeling. Circulation. 2003 Sep 23; 108(12):1487-92. PMID: 12952845.
      View in: PubMed
    70. Sung D, Mills RW, Schettler J, Narayan SM, Omens J, McCulloch AD. Ventricular filling slows epicardial conduction and increases action potential duration in an optical mapping study of the isolated rabbit heart. J Cardiovasc Electrophysiol. 2003 Jul; 14(7):739-49. PMID: 12930255.
      View in: PubMed
    71. Omens J, McCulloch AD, Criscione JC. Complex distributions of residual stress and strain in the mouse left ventricle: experimental and theoretical models. Biomech Model Mechanobiol. 2003 Apr; 1(4):267-77. PMID: 14586695.
      View in: PubMed
    72. Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens J, McCulloch AD. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng. 2003 Mar 05; 81(5):578-87. PMID: 12514807.
      View in: PubMed
    73. Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens J, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002 Dec 27; 111(7):943-55. PMID: 12507422.
      View in: PubMed
    74. Herrmann KL, McCulloch AD, Omens J. Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy. Am J Physiol Heart Circ Physiol. 2003 Apr; 284(4):H1277-84. PMID: 12595292; PMCID: PMC3325795.
    75. Omens J, Usyk TP, Li Z, McCulloch AD. Muscle LIM protein deficiency leads to alterations in passive ventricular mechanics. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H680-7. PMID: 11788418.
      View in: PubMed
    76. Usyk TP, Omens J, McCulloch AD. Regional septal dysfunction in a three-dimensional computational model of focal myofiber disarray. Am J Physiol Heart Circ Physiol. 2001 Aug; 281(2):H506-14. PMID: 11454551.
      View in: PubMed
    77. Mazhari R, Omens J, Pavelec RS, Covell JW, McCulloch AD. Transmural distribution of three-dimensional systolic strains in stunned myocardium. Circulation. 2001 Jul 17; 104(3):336-41. PMID: 11457754.
      View in: PubMed
    78. Paternostro G, Vignola C, Bartsch DU, Omens J, McCulloch AD, Reed JC. Age-associated cardiac dysfunction in Drosophila melanogaster. Circ Res. 2001 May 25; 88(10):1053-8. PMID: 11375275.
      View in: PubMed
    79. Weis SM, Emery JL, Becker KD, McBride DJ, Omens J, McCulloch AD. Myocardial mechanics and collagen structure in the osteogenesis imperfecta murine (oim). Circ Res. 2000 Oct 13; 87(8):663-9. PMID: 11029401.
      View in: PubMed
    80. Sung D, Omens J, McCulloch AD. Model-based analysis of optically mapped epicardial activation patterns and conduction velocity. Ann Biomed Eng. 2000 Sep; 28(9):1085-92. PMID: 11132192.
      View in: PubMed
    81. Mazhari R, Omens J, Covell JW, McCulloch AD. Structural basis of regional dysfunction in acutely ischemic myocardium. Cardiovasc Res. 2000 Aug; 47(2):284-93. PMID: 10946065.
      View in: PubMed
    82. Karlon WJ, McCulloch AD, Covell JW, Hunter JJ, Omens J. Regional dysfunction correlates with myofiber disarray in transgenic mice with ventricular expression of ras. Am J Physiol Heart Circ Physiol. 2000 Mar; 278(3):H898-906. PMID: 10710359; PMCID: PMC3328188.
    83. Zimmerman SD, Karlon WJ, Holmes JW, Omens J, Covell JW. Structural and mechanical factors influencing infarct scar collagen organization. Am J Physiol Heart Circ Physiol. 2000 Jan; 278(1):H194-200. PMID: 10644599.
      View in: PubMed
    84. Karlon WJ, Hsu PP, Li S, Chien S, McCulloch AD, Omens J. Measurement of orientation and distribution of cellular alignment and cytoskeletal organization. Ann Biomed Eng. 1999 Nov-Dec; 27(6):712-20. PMID: 10625144.
      View in: PubMed
    85. Villarreal FJ, Hong D, Omens J. Nicotine-modified postinfarction left ventricular remodeling. Am J Physiol. 1999 Mar; 276(3 Pt 2):H1103-6. PMID: 10070098; PMCID: PMC3343001.
    86. Karlon WJ, Covell JW, McCulloch AD, Hunter JJ, Omens J. Automated measurement of myofiber disarray in transgenic mice with ventricular expression of ras. Anat Rec. 1998 Dec; 252(4):612-25. PMID: 9845212.
      View in: PubMed
    87. Summerour SR, Emery JL, Fazeli B, Omens J, McCulloch AD. Residual strain in ischemic ventricular myocardium. J Biomech Eng. 1998 Dec; 120(6):710-4. PMID: 10412453.
      View in: PubMed
    88. Omens J, Vaplon SM, Fazeli B, McCulloch AD. Left ventricular geometric remodeling and residual stress in the rat heart. J Biomech Eng. 1998 Dec; 120(6):715-9. PMID: 10412454.
      View in: PubMed
    89. Mazhari R, Omens J, Waldman LK, McCulloch AD. Regional myocardial perfusion and mechanics: a model-based method of analysis. Ann Biomed Eng. 1998 Sep-Oct; 26(5):743-55. PMID: 9779946.
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    96. Emery JL, Omens J, McCulloch AD. Strain softening in rat left ventricular myocardium. J Biomech Eng. 1997 Feb; 119(1):6-12. PMID: 9083843.
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    97. Omens J, Miller TR, Covell JW. Relationship between passive tissue strain and collagen uncoiling during healing of infarcted myocardium. Cardiovasc Res. 1997 Feb; 33(2):351-8. PMID: 9074699.
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    98. Omens J, Farr DD, McCulloch AD, Waldman LK. Comparison of two techniques for measuring two-dimensional strain in rat left ventricles. Am J Physiol. 1996 Sep; 271(3 Pt 2):H1256-61. PMID: 8853366.
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    99. Omens J, Rodriguez EK, McCulloch AD. Transmural changes in stress-free myocyte morphology during pressure overload hypertrophy in the rat. J Mol Cell Cardiol. 1996 Sep; 28(9):1975-83. PMID: 8899556.
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    100. MacKenna DA, Omens J, Covell JW. Left ventricular perimysial collagen fibers uncoil rather than stretch during diastolic filling. Basic Res Cardiol. 1996 Mar-Apr; 91(2):111-22. PMID: 8740527.
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    102. Omens J, Milkes DE, Covell JW. Effects of pressure overload on the passive mechanics of the rat left ventricle. Ann Biomed Eng. 1995 Mar-Apr; 23(2):152-63. PMID: 7605052.
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    103. Villarreal FJ, MacKenna DA, Omens J, Dillmann WH. Myocardial remodeling in hypertensive Ren-2 transgenic rats. Hypertension. 1995 Jan; 25(1):98-104. PMID: 7843762.
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    104. May-Newman K, Omens J, Pavelec RS, McCulloch AD. Three-dimensional transmural mechanical interaction between the coronary vasculature and passive myocardium in the dog. Circ Res. 1994 Jun; 74(6):1166-78. PMID: 8187283.
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    106. Omens J, Rockman HA, Covell JW. Passive ventricular mechanics in tight-skin mice. Am J Physiol. 1994 Mar; 266(3 Pt 2):H1169-76. PMID: 8160820.
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    108. Rodriguez EK, Omens J, Waldman LK, McCulloch AD. Effect of residual stress on transmural sarcomere length distributions in rat left ventricle. Am J Physiol. 1993 Apr; 264(4 Pt 2):H1048-56. PMID: 8476082.
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