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    Asa Gustafsson

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0758
    CA La Jolla 92093
    Phone858-822-5569
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      Collapse Biography 
      Collapse Education and Training
      Ph.D.University of California, San Diego

      Collapse Research 
      Collapse Research Activities and Funding
      Role of the Endosomal-Lysosomal Pathway in Mitochondrial Quality Control
      NIH/NHLBI R01HL138560Aug 15, 2017 - May 31, 2021
      Role: Principal Investigator
      MCL-1 is a critical regulator of mitochondrial dynamics and function in myocytes
      NIH/NHLBI R01HL132300Feb 1, 2017 - Jan 31, 2021
      Role: Principal Investigator
      Mitochondrial Quality Control in the Aging Myocardium
      NIH/NIA R21AG052280May 1, 2016 - Apr 30, 2018
      Role: Principal Investigator
      Mcl-1 as an essential regulator of cardiac mitochondrial function
      NIH/NHLBI R01HL101217May 1, 2010 - Mar 31, 2014
      Role: Principal Investigator
      Juvenile mouse model of delayed anthracycline cardiotoxicity
      NIH/NHLBI R01HL092136Dec 19, 2008 - Feb 28, 2014
      Role: Principal Investigator
      Regulation of Mitochondrial Autophagy by Parkin
      NIH/NHLBI R01HL087023Dec 1, 2006 - May 31, 2017
      Role: Principal Investigator
      Restoring Mycocardial Healing
      NIH P01HL085577Jul 1, 2006 - Jul 31, 2018
      Role: Co-Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson A, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. NF-?B Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910. PMID: 26919428; PMCID: PMC4769378 [Available on 02/25/17].
      2. Din S, Konstandin MH, Johnson B, Emathinger J, Völkers M, Toko H, Collins B, Ormachea L, Samse K, Kubli DA, De La Torre A, Kraft AS, Gustafsson A, Kelly DP, Sussman MA. Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases. Circ Res. 2014 Jul 18; 115(3):376-87. PMID: 24916111; PMCID: PMC4254755.
      3. Kubli DA, Gustafsson A. Cardiomyocyte health: adapting to metabolic changes through autophagy. Trends Endocrinol Metab. 2014 Mar; 25(3):156-64. PMID: 24370004; PMCID: PMC3951169.
      4. Abeliovich H, Chen Q, Devenish R, Gustafsson A, Sánchez Alcázar JA. Autophagy researchers. Autophagy. 2013 Nov 01; 9(11):1648-52. PMID: 24121709.
        View in: PubMed
      5. Thomas RL, Gustafsson A. MCL1 is critical for mitochondrial function and autophagy in the heart. Autophagy. 2013 Nov 01; 9(11):1902-3. PMID: 24165322; PMCID: PMC4028340.
      6. Thomas RL, Gustafsson A. Mitochondrial autophagy--an essential quality control mechanism for myocardial homeostasis. Circ J. 2013; 77(10):2449-54. PMID: 23985961; PMCID: PMC4028823.
      7. Kubli DA, Quinsay MN, Gustafsson A. Parkin deficiency results in accumulation of abnormal mitochondria in aging myocytes. Commun Integr Biol. 2013 Jul 01; 6(4):e24511. PMID: 23986804; PMCID: PMC3737749.
      8. Kubli DA, Zhang X, Lee Y, Hanna RA, Quinsay MN, Nguyen CK, Jimenez R, Petrosyan S, Murphy AN, Gustafsson A. Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem. 2013 Jan 11; 288(2):915-26. PMID: 23152496; PMCID: PMC3543040.
      9. Lee Y, Lee HY, Gustafsson A. Regulation of autophagy by metabolic and stress signaling pathways in the heart. J Cardiovasc Pharmacol. 2012 Aug; 60(2):118-24. PMID: 22472907; PMCID: PMC3419780.
      10. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490; PMCID: PMC3404883.
      11. Ong SB, Gustafsson A. New roles for mitochondria in cell death in the reperfused myocardium. Cardiovasc Res. 2012 May 01; 94(2):190-6. PMID: 22108916; PMCID: PMC3331612.
      12. Thomas RL, Kubli DA, Gustafsson A. Bnip3-mediated defects in oxidative phosphorylation promote mitophagy. Autophagy. 2011 Jul; 7(7):775-7. PMID: 21460627.
        View in: PubMed
      13. Gustafsson A. Bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardium. Pediatr Cardiol. 2011 Mar; 32(3):267-74. PMID: 21210091; PMCID: PMC3051075.
      14. Gottlieb RA, Gustafsson A. Mitochondrial turnover in the heart. Biochim Biophys Acta. 2011 Jul; 1813(7):1295-301. PMID: 21147177; PMCID: PMC3335292.
      15. Quinsay MN, Thomas RL, Lee Y, Gustafsson A. Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy. 2010 Oct; 6(7):855-62. PMID: 20668412; PMCID: PMC3039735.
      16. Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson A, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res. 2010 Apr 16; 106(7):1265-74. PMID: 20203306; PMCID: PMC2864233.
      17. Huang C, Zhang X, Ramil JM, Rikka S, Kim L, Lee Y, Gude NA, Thistlethwaite PA, Sussman MA, Gottlieb RA, Gustafsson A. Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation. 2010 Feb 09; 121(5):675-83. PMID: 20100968; PMCID: PMC2834271.
      18. Quinsay MN, Lee Y, Rikka S, Sayen MR, Molkentin JD, Gottlieb RA, Gustafsson A. Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism. J Mol Cell Cardiol. 2010 Jun; 48(6):1146-56. PMID: 20025887; PMCID: PMC2866782.
      19. Lee Y, Gustafsson A. Role of apoptosis in cardiovascular disease. Apoptosis. 2009 Apr; 14(4):536-48. PMID: 19142731.
        View in: PubMed
      20. Yitzhaki S, Huang C, Liu W, Lee Y, Gustafsson A, Mentzer RM, Gottlieb RA. Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA. Basic Res Cardiol. 2009 Mar; 104(2):157-67. PMID: 19242639; PMCID: PMC3682823.
      21. Gustafsson A, Gottlieb RA. Autophagy in ischemic heart disease. Circ Res. 2009 Jan 30; 104(2):150-8. PMID: 19179668; PMCID: PMC2765251.
      22. Kubli DA, Quinsay MN, Huang C, Lee Y, Gustafsson A. Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol. 2008 Nov; 295(5):H2025-31. PMID: 18790835; PMCID: PMC2614576.
      23. Gustafsson A, Gottlieb RA. Recycle or die: the role of autophagy in cardioprotection. J Mol Cell Cardiol. 2008 Apr; 44(4):654-61. PMID: 18353358; PMCID: PMC2423346.
      24. Gustafsson A, Gottlieb RA. Eat your heart out: Role of autophagy in myocardial ischemia/reperfusion. Autophagy. 2008 May; 4(4):416-21. PMID: 18253087; PMCID: PMC3723414.
      25. Gustafsson A, Gottlieb RA. Heart mitochondria: gates of life and death. Cardiovasc Res. 2008 Jan 15; 77(2):334-43. PMID: 18006487.
        View in: PubMed
      26. Kubli DA, Ycaza JE, Gustafsson A. Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak. Biochem J. 2007 Aug 01; 405(3):407-15. PMID: 17447897; PMCID: PMC2267317.
      27. Hamacher-Brady A, Brady NR, Gottlieb RA, Gustafsson A. Autophagy as a protective response to Bnip3-mediated apoptotic signaling in the heart. Autophagy. 2006 Oct-Dec; 2(4):307-9. PMID: 16874059.
        View in: PubMed
      28. Gustafsson A, Gottlieb RA. Bcl-2 family members and apoptosis, taken to heart. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C45-51. PMID: 16943242.
        View in: PubMed
      29. Wall JA, Wei J, Ly M, Belmont P, Martindale JJ, Tran D, Sun J, Chen WJ, Yu W, Oeller P, Briggs S, Gustafsson A, Sayen MR, Gottlieb RA, Glembotski CC. Alterations in oxidative phosphorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2462-72. PMID: 16766635.
        View in: PubMed
      30. Hamacher-Brady A, Brady NR, Logue SE, Sayen MR, Jinno M, Kirshenbaum LA, Gottlieb RA, Gustafsson A. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ. 2007 Jan; 14(1):146-57. PMID: 16645637.
        View in: PubMed
      31. Gustafsson A, Gottlieb RA, Granville DJ. TAT-mediated protein transduction: delivering biologically active proteins to the heart. Methods Mol Med. 2005; 112:81-90. PMID: 16010012.
        View in: PubMed
      32. Logue SE, Gustafsson A, Samali A, Gottlieb RA. Ischemia/reperfusion injury at the intersection with cell death. J Mol Cell Cardiol. 2005 Jan; 38(1):21-33. PMID: 15623419.
        View in: PubMed
      33. Hilal-Dandan R, Means CK, Gustafsson A, Morissette MR, Adams JW, Brunton LL, Heller Brown J. Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. J Mol Cell Cardiol. 2004 Apr; 36(4):481-93. PMID: 15081308.
        View in: PubMed
      34. Gustafsson A, Tsai JG, Logue SE, Crow MT, Gottlieb RA. Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation. J Biol Chem. 2004 May 14; 279(20):21233-8. PMID: 15004034.
        View in: PubMed
      35. Granville DJ, Tashakkor B, Takeuchi C, Gustafsson A, Huang C, Sayen MR, Wentworth P, Yeager M, Gottlieb RA. Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Proc Natl Acad Sci U S A. 2004 Feb 03; 101(5):1321-6. PMID: 14734800; PMCID: PMC337051.
      36. Gustafsson A, Gottlieb RA. Mechanisms of apoptosis in the heart. J Clin Immunol. 2003 Nov; 23(6):447-59. PMID: 15031632.
        View in: PubMed
      37. Sayen MR, Gustafsson A, Sussman MA, Molkentin JD, Gottlieb RA. Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production. Am J Physiol Cell Physiol. 2003 Feb; 284(2):C562-70. PMID: 12397029.
        View in: PubMed
      38. Gustafsson A, Sayen MR, Williams SD, Crow MT, Gottlieb RA. TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotective. Circulation. 2002 Aug 06; 106(6):735-9. PMID: 12163436.
        View in: PubMed
      39. Gustafsson A, Brunton LL. Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1beta and NO: role of cGMP-stimulated PDE2. Am J Physiol Cell Physiol. 2002 Aug; 283(2):C463-71. PMID: 12107056.
        View in: PubMed
      40. Xu J, Moonen M, Johansson A, Gustafsson A, Bake B. Quantitative analysis of inhomogeneity in ventilation SPET. Eur J Nucl Med. 2001 Dec; 28(12):1795-800. PMID: 11734917.
        View in: PubMed
      41. Gustafsson A, Brunton LL. beta-adrenergic stimulation of rat cardiac fibroblasts enhances induction of nitric-oxide synthase by interleukin-1beta via message stabilization. Mol Pharmacol. 2000 Dec; 58(6):1470-8. PMID: 11093787.
        View in: PubMed
      42. Gustafsson A, Brunton LL. Differential and selective inhibition of protein kinase A and protein kinase C in intact cells by balanol congeners. Mol Pharmacol. 1999 Aug; 56(2):377-82. PMID: 10419557.
        View in: PubMed
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