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Asa Gustafsson

Title(s)Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Ph.D.University of California, San Diego

    Collapse Research 
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    Role of the Endosomal-Lysosomal Pathway in Mitochondrial Quality Control
    NIH/NHLBI R01HL138560Aug 15, 2017 - May 31, 2021
    Role: Principal Investigator
    MCL-1 is a critical regulator of mitochondrial dynamics and function in myocytes
    NIH/NHLBI R01HL132300Feb 1, 2017 - Jan 31, 2021
    Role: Principal Investigator
    Mitochondrial Quality Control in the Aging Myocardium
    NIH/NIA R21AG052280May 1, 2016 - Apr 30, 2018
    Role: Principal Investigator
    Mcl-1 as an essential regulator of cardiac mitochondrial function
    NIH/NHLBI R01HL101217May 1, 2010 - Mar 31, 2014
    Role: Principal Investigator
    Juvenile mouse model of delayed anthracycline cardiotoxicity
    NIH/NHLBI R01HL092136Dec 19, 2008 - Nov 30, 2013
    Role: Principal Investigator
    Regulation of Mitochondrial Autophagy by Parkin
    NIH/NHLBI R01HL087023Dec 1, 2006 - Sep 30, 2009
    Role: Principal Investigator
    Restoring Mycocardial Healing
    NIH P01HL085577Jul 1, 2006 - Jul 31, 2018
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. PMID: 26919428.
      View in: PubMed   Mentions: 188     Fields:    Translation:AnimalsCells
    2. Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases. Circ Res. 2014 Jul 18; 115(3):376-87. Din S, Konstandin MH, Johnson B, Emathinger J, Völkers M, Toko H, Collins B, Ormachea L, Samse K, Kubli DA, De La Torre A, Kraft AS, Gustafsson AB, Kelly DP, Sussman MA. PMID: 24916111.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    3. Cardiomyocyte health: adapting to metabolic changes through autophagy. Trends Endocrinol Metab. 2014 Mar; 25(3):156-64. Kubli DA, Gustafsson AB. PMID: 24370004.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    4. Autophagy researchers. Autophagy. 2013 Nov 01; 9(11):1648-52. Abeliovich H, Chen Q, Devenish R, Gustafsson A, Sánchez Alcázar JA. PMID: 24121709.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. MCL1 is critical for mitochondrial function and autophagy in the heart. Autophagy. 2013 Nov 01; 9(11):1902-3. Thomas RL, Gustafsson AB. PMID: 24165322.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    6. Mitochondrial autophagy--an essential quality control mechanism for myocardial homeostasis. Circ J. 2013; 77(10):2449-54. Thomas RL, Gustafsson AB. PMID: 23985961.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    7. Parkin deficiency results in accumulation of abnormal mitochondria in aging myocytes. Commun Integr Biol. 2013 Jul 01; 6(4):e24511. Kubli DA, Quinsay MN, Gustafsson AB. PMID: 23986804.
      View in: PubMed   Mentions:
    8. Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem. 2013 Jan 11; 288(2):915-26. Kubli DA, Zhang X, Lee Y, Hanna RA, Quinsay MN, Nguyen CK, Jimenez R, Petrosyan S, Murphy AN, Gustafsson AB. PMID: 23152496.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    9. Regulation of autophagy by metabolic and stress signaling pathways in the heart. J Cardiovasc Pharmacol. 2012 Aug; 60(2):118-24. Lee Y, Lee HY, Gustafsson AB. PMID: 22472907.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    10. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. PMID: 22966490.
      View in: PubMed   Mentions: 1502     Fields:    Translation:HumansAnimals
    11. New roles for mitochondria in cell death in the reperfused myocardium. Cardiovasc Res. 2012 May 01; 94(2):190-6. Ong SB, Gustafsson AB. PMID: 22108916.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    12. Bnip3-mediated defects in oxidative phosphorylation promote mitophagy. Autophagy. 2011 Jul; 7(7):775-7. Thomas RL, Kubli DA, Gustafsson AB. PMID: 21460627.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardium. Pediatr Cardiol. 2011 Mar; 32(3):267-74. Gustafsson AB. PMID: 21210091.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    14. Mitochondrial turnover in the heart. Biochim Biophys Acta. 2011 Jul; 1813(7):1295-301. Gottlieb RA, Gustafsson AB. PMID: 21147177.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    15. Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy. 2010 Oct; 6(7):855-62. Quinsay MN, Thomas RL, Lee Y, Gustafsson AB. PMID: 20668412.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    16. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res. 2010 Apr 16; 106(7):1265-74. Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA. PMID: 20203306.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    17. Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation. 2010 Feb 09; 121(5):675-83. Huang C, Zhang X, Ramil JM, Rikka S, Kim L, Lee Y, Gude NA, Thistlethwaite PA, Sussman MA, Gottlieb RA, Gustafsson AB. PMID: 20100968.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    18. Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism. J Mol Cell Cardiol. 2010 Jun; 48(6):1146-56. Quinsay MN, Lee Y, Rikka S, Sayen MR, Molkentin JD, Gottlieb RA, Gustafsson AB. PMID: 20025887.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    19. Role of apoptosis in cardiovascular disease. Apoptosis. 2009 Apr; 14(4):536-48. Lee Y, Gustafsson AB. PMID: 19142731.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    20. Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA. Basic Res Cardiol. 2009 Mar; 104(2):157-67. Yitzhaki S, Huang C, Liu W, Lee Y, Gustafsson AB, Mentzer RM, Gottlieb RA. PMID: 19242639.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    21. Autophagy in ischemic heart disease. Circ Res. 2009 Jan 30; 104(2):150-8. Gustafsson AB, Gottlieb RA. PMID: 19179668.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    22. Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion. . 2008 Nov; 295(5):H2025-31. Kubli DA, Quinsay MN, Huang C, Lee Y, Gustafsson AB. PMID: 18790835.
      View in: PubMed   Mentions:
    23. Recycle or die: the role of autophagy in cardioprotection. J Mol Cell Cardiol. 2008 Apr; 44(4):654-61. Gustafsson AB, Gottlieb RA. PMID: 18353358.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimals
    24. Eat your heart out: Role of autophagy in myocardial ischemia/reperfusion. Autophagy. 2008 May; 4(4):416-21. Gustafsson AB, Gottlieb RA. PMID: 18253087.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    25. Heart mitochondria: gates of life and death. Cardiovasc Res. 2008 Jan 15; 77(2):334-43. Gustafsson AB, Gottlieb RA. PMID: 18006487.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    26. Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak. Biochem J. 2007 Aug 01; 405(3):407-15. Kubli DA, Ycaza JE, Gustafsson AB. PMID: 17447897.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    27. Autophagy as a protective response to Bnip3-mediated apoptotic signaling in the heart. Autophagy. 2006 Oct-Dec; 2(4):307-9. Hamacher-Brady A, Brady NR, Gottlieb RA, Gustafsson AB. PMID: 16874059.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    28. Bcl-2 family members and apoptosis, taken to heart. . 2007 Jan; 292(1):C45-51. Gustafsson AB, Gottlieb RA. PMID: 16943242.
      View in: PubMed   Mentions:
    29. Alterations in oxidative phosphorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6. . 2006 Nov; 291(5):H2462-72. Wall JA, Wei J, Ly M, Belmont P, Martindale JJ, Tran D, Sun J, Chen WJ, Yu W, Oeller P, Briggs S, Gustafsson AB, Sayen MR, Gottlieb RA, Glembotski CC. PMID: 16766635.
      View in: PubMed   Mentions:
    30. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ. 2007 Jan; 14(1):146-57. Hamacher-Brady A, Brady NR, Logue SE, Sayen MR, Jinno M, Kirshenbaum LA, Gottlieb RA, Gustafsson AB. PMID: 16645637.
      View in: PubMed   Mentions: 242     Fields:    Translation:AnimalsCells
    31. TAT-mediated protein transduction: delivering biologically active proteins to the heart. Methods Mol Med. 2005; 112:81-90. Gustafsson AB, Gottlieb RA, Granville DJ. PMID: 16010012.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. Ischemia/reperfusion injury at the intersection with cell death. J Mol Cell Cardiol. 2005 Jan; 38(1):21-33. Logue SE, Gustafsson AB, Samali A, Gottlieb RA. PMID: 15623419.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    33. Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. J Mol Cell Cardiol. 2004 Apr; 36(4):481-93. Hilal-Dandan R, Means CK, Gustafsson AB, Morissette MR, Adams JW, Brunton LL, Heller Brown J. PMID: 15081308.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    34. Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation. J Biol Chem. 2004 May 14; 279(20):21233-8. Gustafsson AB, Tsai JG, Logue SE, Crow MT, Gottlieb RA. PMID: 15004034.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    35. Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Proc Natl Acad Sci U S A. 2004 Feb 03; 101(5):1321-6. Granville DJ, Tashakkor B, Takeuchi C, Gustafsson AB, Huang C, Sayen MR, Wentworth P, Yeager M, Gottlieb RA. PMID: 14734800.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    36. Mechanisms of apoptosis in the heart. J Clin Immunol. 2003 Nov; 23(6):447-59. Gustafsson AB, Gottlieb RA. PMID: 15031632.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    37. Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production. . 2003 Feb; 284(2):C562-70. Sayen MR, Gustafsson AB, Sussman MA, Molkentin JD, Gottlieb RA. PMID: 12397029.
      View in: PubMed   Mentions:
    38. TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotective. Circulation. 2002 Aug 06; 106(6):735-9. Gustafsson AB, Sayen MR, Williams SD, Crow MT, Gottlieb RA. PMID: 12163436.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    39. Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1beta and NO: role of cGMP-stimulated PDE2. . 2002 Aug; 283(2):C463-71. Gustafsson AB, Brunton LL. PMID: 12107056.
      View in: PubMed   Mentions:
    40. Quantitative analysis of inhomogeneity in ventilation SPET. Eur J Nucl Med. 2001 Dec; 28(12):1795-800. Xu J, Moonen M, Johansson A, Gustafsson A, Bake B. PMID: 11734917.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. beta-adrenergic stimulation of rat cardiac fibroblasts enhances induction of nitric-oxide synthase by interleukin-1beta via message stabilization. Mol Pharmacol. 2000 Dec; 58(6):1470-8. Gustafsson AB, Brunton LL. PMID: 11093787.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    42. Differential and selective inhibition of protein kinase A and protein kinase C in intact cells by balanol congeners. Mol Pharmacol. 1999 Aug; 56(2):377-82. Gustafsson AB, Brunton LL. PMID: 10419557.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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