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David Broide

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0635
La Jolla CA 92093
Phone858-534-2374
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    Collapse Overview 
    Collapse Overview
    Research Interests
    Mechanisms of allergic inflammation and asthma
    Airway hyperreactivity, airway inflammation, mucus expression, and airway remodeling
    Immunohistology and image analysis quantitation of eosinophils, mast cells, T cells, and macrophages in the lung
    Eosinophils and mast cells in vitro and in vivo


    Collapse Research 
    Collapse Research Activities and Funding
    Amelioration of rhinovirus induced asthma exacerbations by serpin B1
    NIH/NIAID R41AI141068Jun 1, 2018 - May 31, 2019
    Role: Co-Principal Investigator
    GSDMB and mucosal allergic response
    NIH/NIAID R01AI124236Sep 1, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Chromosome 17q, allergic inflammation, and remodeling
    NIH/NIAID R01AI107779May 15, 2013 - Apr 30, 2018
    Role: Principal Investigator
    LIAI Epitope Validation Center: Characterization of Allergen specific T Cells
    NIH U19AI100275Apr 1, 2012 - Mar 31, 2017
    Role: Co-Investigator
    Siglec-F and Resolution of Allergic Inflammation
    NIH/NIAID R01AI072115Dec 15, 2007 - Nov 30, 2013
    Role: Principal Investigator
    Airway inflammation and airway remodeling
    NIH/NIAID U19AI070535Jul 1, 2006 - Aug 31, 2021
    Role: Principal Investigator
    Biomarkers in sputum in COPD
    NIH/NHLBI R01HL072342Sep 23, 2002 - Jul 31, 2008
    Role: Principal Investigator
    RSV AND ASTHMA
    NIH/NIAID R01AI045513Mar 1, 1999 - Feb 28, 2005
    Role: Principal Investigator
    Eosinophil trafficking and chronic tissue damage induced by allergic inflammation
    NIH/NIAID R37AI038425Apr 1, 1996 - Nov 30, 2016
    Role: Principal Investigator
    Eosinophil Trafficking
    NIH/NIAID R01AI038425Apr 1, 1996 - Dec 14, 2006
    Role: Principal Investigator
    Training in Molecular and Cell Biology of Allergy
    NIH/NIAID T32AI007469Sep 30, 1994 - Jun 30, 2019
    Role: Principal Investigator
    ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    NIH/NIAID R01AI033977May 1, 1994 - Dec 31, 2002
    Role: Principal Investigator
    ASTHMA--CYTOKINES AND AIRWAY INFLAMMATION
    NIH/NIAID R29AI029974Mar 1, 1991 - Feb 29, 1996
    Role: Principal Investigator
    GROWTH FACTOR REGULATION OF MUCOSAL MAST CELLS
    NIH/NIAID K08AI000845Sep 30, 1987 - Aug 31, 1990
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Moore E, Grifoni A, Weiskopf D, Schulten V, Arlehamn CSL, Angelo M, Pham J, Leary S, Sidney J, Broide D, Frazier A, Phillips E, Mallal S, Mack SJ, Sette A. Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA. Hum Immunol. 2018 Sep 29. PMID: 30278218.
      View in: PubMed
    2. Miller M, Vuong C, Garcia MF, Rosenthal P, Das S, Weng N, Pham A, Kim YJ, Broide DH. Does reduced ZPBP2 expression on chromosome 17q21 protect against asthma ? J Allergy Clin Immunol. 2018 Apr 27. PMID: 29709669.
      View in: PubMed
    3. Doherty TA, Broide DH. Lipid regulation of group 2 innate lymphoid cell function: Moving beyond epithelial cytokines. J Allergy Clin Immunol. 2018 May; 141(5):1587-1589. PMID: 29522852.
      View in: PubMed
    4. Mehta AK, Doherty T, Broide D, Croft M. Tumor necrosis factor family member LIGHT acts with IL-1ß and TGF-ß to promote airway remodeling during rhinovirus infection. Allergy. 2018 Jan 09. PMID: 29315623.
      View in: PubMed
    5. Unno H, Miller M, Rosenthal P, Beppu A, Das S, Broide DH. Activating transcription factor 6a (ATF6a) regulates airway hyperreactivity, smooth muscle proliferation, and contractility. J Allergy Clin Immunol. 2018 Jan; 141(1):439-442.e4. PMID: 28958904.
      View in: PubMed
    6. Chen J, Miller M, Unno H, Rosenthal P, Sanderson MJ, Broide DH. Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca2+ oscillations in asthma. J Allergy Clin Immunol. 2017 Sep 07. PMID: 28889952.
      View in: PubMed
    7. Song DJ, Miller M, Beppu A, Rosenthal P, Das S, Karta M, Vuong C, Mehta AK, Croft M, Broide DH. Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation. J Immunol. 2017 10 01; 199(7):2215-2224. PMID: 28827284.
      View in: PubMed
    8. Das S, Miller M, Broide DH. Chromosome 17q21 Genes ORMDL3 and GSDMB in Asthma and Immune Diseases. Adv Immunol. 2017; 135:1-52. PMID: 28826527.
      View in: PubMed
    9. Lund SJ, Portillo A, Cavagnero K, Baum RE, Naji LH, Badrani JH, Mehta A, Croft M, Broide DH, Doherty TA. Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation. J Immunol. 2017 08 01; 199(3):1096-1104. PMID: 28667163.
      View in: PubMed
    10. Liu T, Liu Y, Miller M, Cao L, Zhao J, Wu J, Wang J, Liu L, Li S, Zou M, Xu J, Broide DH, Dong L. Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma. Am J Physiol Lung Cell Mol Physiol. 2017 Jul 01; 313(1):L27-L40. PMID: 28473327.
      View in: PubMed
    11. Karta MR, Rosenthal PS, Beppu A, Vuong CY, Miller M, Das S, Kurten RC, Doherty TA, Broide DH. ß2 integrins rather than ß1 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung. J Allergy Clin Immunol. 2018 Jan; 141(1):329-338.e12. PMID: 28366795.
      View in: PubMed
    12. Miller M, Tam AB, Mueller JL, Rosenthal P, Beppu A, Gordillo R, McGeough MD, Vuong C, Doherty TA, Hoffman HM, Niwa M, Broide DH. Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. J Immunol. 2017 04 15; 198(8):3017-3022. PMID: 28275141.
      View in: PubMed
    13. Eastman JJ, Cavagnero KJ, Deconde AS, Kim AS, Karta MR, Broide DH, Zuraw BL, White AA, Christiansen SC, Doherty TA. Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2017 Jul; 140(1):101-108.e3. PMID: 28279492.
      View in: PubMed
    14. Dewitz C, McEachern E, Shin S, Akong K, Nagle DG, Broide DH, Akuthota P, Crotty Alexander LE. Hypoxia-inducible factor-1a inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma. Clin Immunol. 2017 03; 176:94-99. PMID: 28093362.
      View in: PubMed
    15. Doherty TA, Broide DH. Pathways to limit group 2 innate lymphoid cell activation. J Allergy Clin Immunol. 2017 May; 139(5):1465-1467. PMID: 28087226.
      View in: PubMed
    16. Kim AS, Broide DH. Acute renal dysfunction caused by nonsucrose intravenous immunoglobulin in common variable immunodeficiency. Ann Allergy Asthma Immunol. 2017 Feb; 118(2):231-233. PMID: 28024991.
      View in: PubMed
    17. Miller M, Rosenthal P, Beppu A, Gordillo R, Broide DH. Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide. J Allergy Clin Immunol. 2017 Apr; 139(4):1373-1376.e4. PMID: 27826095.
      View in: PubMed
    18. Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty TA, Kurten RC, Hamid Q, Hoffman HM, Broide DH. GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13132-13137. PMID: 27799535.
      View in: PubMed
    19. Seumois G, Zapardiel-Gonzalo J, White B, Singh D, Schulten V, Dillon M, Hinz D, Broide DH, Sette A, Peters B, Vijayanand P. Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma. J Immunol. 2016 07 15; 197(2):655-64. PMID: 27271570; PMCID: PMC4936908 [Available on 07/15/17].
    20. Hinz D, Seumois G, Gholami AM, Greenbaum JA, Lane J, White B, Broide DH, Schulten V, Sidney J, Bakhru P, Oseroff C, Wambre E, James EA, Kwok WW, Peters B, Vijayanand P, Sette A. Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with the allergen-specific modulation of immune reactivity. Clin Exp Allergy. 2016 May; 46(5):705-19. PMID: 26662458; PMCID: PMC4846575 [Available on 05/01/17].
    21. Miller M, Esnault S, Kurten RC, Kelly EA, Beppu A, Das S, Rosenthal P, Ramsdell J, Croft M, Zuraw B, Jarjour N, Hamid Q, Broide DH. Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma. J Allergy Clin Immunol. 2016 Aug; 138(2):596-599.e4. PMID: 27001159; PMCID: PMC4975994 [Available on 08/01/17].
    22. Rawson R, Yang T, Newbury RO, Aquino M, Doshi A, Bell B, Broide DH, Dohil R, Kurten R, Aceves SS. TGF-ß1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2016 Sep; 138(3):791-800.e4. PMID: 27212082; PMCID: PMC5014565 [Available on 09/01/17].
    23. Kim AS, Doherty TA, Karta MR, Das S, Baum R, Rosenthal P, Beppu A, Miller M, Kurten R, Broide DH. Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis. J Allergy Clin Immunol. 2016 Oct; 138(4):1192-1195.e5. PMID: 27142393.
      View in: PubMed
    24. Cho S, Wu CJ, Yasuda T, Cruz LO, Khan AA, Lin LL, Nguyen DT, Miller M, Lee HM, Kuo ML, Broide DH, Rajewsky K, Rudensky AY, Lu LF. miR-23~27~24 clusters control effector T cell differentiation and function. J Exp Med. 2016 Feb 08; 213(2):235-49. PMID: 26834155; PMCID: PMC4749926.
    25. Zhou W, Toki S, Zhang J, Goleniewksa K, Newcomb DC, Cephus JY, Dulek DE, Bloodworth MH, Stier MT, Polosuhkin V, Gangula RD, Mallal SA, Broide DH, Peebles RS. Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses. Am J Respir Crit Care Med. 2016 Jan 01; 193(1):31-42. PMID: 26378386; PMCID: PMC4731613 [Available on 01/01/17].
    26. Karta MR, Broide DH, Doherty TA. Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease. Curr Allergy Asthma Rep. 2016 Jan; 16(1):8. PMID: 26746844; PMCID: PMC5026503.
    27. Rawson R, Anilkumar A, Newbury RO, Bafna V, Aquino M, Palmquist J, Hoffman HM, Mueller JL, Dohil R, Broide DH, Aceves SS. The TGFß1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis. PLoS One. 2015; 10(12):e0144651. PMID: 26656423; PMCID: PMC4678166.
    28. Miller M, Beppu A, Rosenthal P, Pham A, Das S, Karta M, Song DJ, Vuong C, Doherty T, Croft M, Zuraw B, Zhang X, Gao X, Aceves S, Chouiali F, Hamid Q, Broide DH. Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M. J Immunol. 2015 Oct 15; 195(8):3546-56. PMID: 26355153; PMCID: PMC4811198 [Available on 10/15/16].
    29. Beppu L, Yang T, Luk M, Newbury RO, Palmquist J, Dohil R, Kurten RC, Broide DH, Aceves SS. MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid Therapy. J Pediatr Gastroenterol Nutr. 2015 Aug; 61(2):194-9. PMID: 25539192; PMCID: PMC4478274.
    30. Doherty TA, Baum R, Newbury RO, Yang T, Dohil R, Aquino M, Doshi A, Walford HH, Kurten RC, Broide DH, Aceves S. Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis. J Allergy Clin Immunol. 2015 Sep; 136(3):792-794.e3. PMID: 26233928.
      View in: PubMed
    31. Rajan J, Newbury RO, Anilkumar A, Dohil R, Broide DH, Aceves SS. Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids. J Allergy Clin Immunol. 2016 Jan; 137(1):147-156.e8. PMID: 26233926.
      View in: PubMed
    32. Mehta AK, Duan W, Doerner AM, Traves SL, Broide DH, Proud D, Zuraw BL, Croft M. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33. J Allergy Clin Immunol. 2016 Jan; 137(1):278-288.e6. PMID: 26100084; PMCID: PMC4684822 [Available on 01/01/17].
    33. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1529-34. PMID: 25605931; PMCID: PMC4321256.
    34. Doherty TA, Broide DH. Group 2 innate lymphoid cells: new players in human allergic diseases. J Investig Allergol Clin Immunol. 2015; 25(1):1-11; quiz 2p following 11. PMID: 25898689; PMCID: PMC4545833.
    35. Walford HH, Lund SJ, Baum RE, White AA, Bergeron CM, Husseman J, Bethel KJ, Scott DR, Khorram N, Miller M, Broide DH, Doherty TA. Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness. Clin Immunol. 2014 Nov; 155(1):126-35. PMID: 25236785; PMCID: PMC4254351.
    36. Schulten V, Tripple V, Sidney J, Greenbaum J, Frazier A, Alam R, Broide D, Peters B, Sette A. Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy. J Allergy Clin Immunol. 2014 Nov; 134(5):1076-83. PMID: 25042980.
      View in: PubMed
    37. Cho JY, Doshi A, Rosenthal P, Beppu A, Miller M, Aceves S, Broide D. Smad3-deficient mice have reduced esophageal fibrosis and angiogenesis in a model of egg-induced eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2014 Jul; 59(1):10-6. PMID: 24590208; PMCID: PMC4148477.
    38. Miyazaki M, Miyazaki K, Chen S, Itoi M, Miller M, Lu LF, Varki N, Chang AN, Broide DH, Murre C. Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease. Nat Immunol. 2014 Aug; 15(8):767-76. PMID: 24973820; PMCID: PMC4365819.
    39. Nonaka M, Bao X, Matsumura F, Götze S, Kandasamy J, Kononov A, Broide DH, Nakayama J, Seeberger PH, Fukuda M. Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8173-8. PMID: 24835176; PMCID: PMC4050563.
    40. Beppu LY, Anilkumar AA, Newbury RO, Dohil R, Broide DH, Aceves SS. TGF-ß1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Nov; 134(5):1100-1107.e4. PMID: 24835503.
      View in: PubMed
    41. Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, Doherty TA, McGeough MD, Pena CA, Suzukawa M, Niwa M, Broide DH. ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma. J Immunol. 2014 Apr 15; 192(8):3475-87. PMID: 24623133; PMCID: PMC3981544.
    42. Doherty TA, Scott D, Walford HH, Khorram N, Lund S, Baum R, Chang J, Rosenthal P, Beppu A, Miller M, Broide DH. Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84. J Allergy Clin Immunol. 2014 Apr; 133(4):1203-5. PMID: 24582313.
      View in: PubMed
    43. Cho JY, Rosenthal P, Miller M, Pham A, Aceves S, Sakuda S, Broide DH. Targeting AMCase reduces esophageal eosinophilic inflammation and remodeling in a mouse model of egg induced eosinophilic esophagitis. Int Immunopharmacol. 2014 Jan; 18(1):35-42. PMID: 24239745; PMCID: PMC3908829.
    44. Chang JE, Doherty TA, Baum R, Broide D. Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis. J Allergy Clin Immunol. 2014 Mar; 133(3):899-901.e3. PMID: 24210841.
      View in: PubMed
    45. Kuo YC, Li YS, Zhou J, Shih YR, Miller M, Broide D, Lee OK, Chien S. Human mesenchymal stem cells suppress the stretch-induced inflammatory miR-155 and cytokines in bronchial epithelial cells. PLoS One. 2013; 8(8):e71342. PMID: 23967196; PMCID: PMC3742760.
    46. Doherty TA, Khorram N, Lund S, Mehta AK, Croft M, Broide DH. Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. J Allergy Clin Immunol. 2013 Jul; 132(1):205-13. PMID: 23688412.
      View in: PubMed
    47. Suzukawa M, Miller M, Rosenthal P, Cho JY, Doherty TA, Varki A, Broide D. Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice. J Immunol. 2013 Jun 15; 190(12):5939-48. PMID: 23677475; PMCID: PMC3679360.
    48. Otani IM, Anilkumar AA, Newbury RO, Bhagat M, Beppu LY, Dohil R, Broide DH, Aceves SS. Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2013 Jun; 131(6):1576-82. PMID: 23623266.
      View in: PubMed
    49. Soroosh P, Doherty TA, Duan W, Mehta AK, Choi H, Adams YF, Mikulski Z, Khorram N, Rosenthal P, Broide DH, Croft M. Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance. J Exp Med. 2013 Apr 08; 210(4):775-88. PMID: 23547101; PMCID: PMC3620360.
    50. Baek KJ, Cho JY, Rosenthal P, Alexander LE, Nizet V, Broide DH. Hypoxia potentiates allergen induction of HIF-1a, chemokines, airway inflammation, TGF-ß1, and airway remodeling in a mouse model. Clin Immunol. 2013 Apr; 147(1):27-37. PMID: 23499929; PMCID: PMC3812068.
    51. Schulten V, Greenbaum JA, Hauser M, McKinney DM, Sidney J, Kolla R, Lindestam Arlehamn CS, Oseroff C, Alam R, Broide DH, Ferreira F, Ferreira-Briza F, Grey HM, Sette A, Peters B. Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3459-64. PMID: 23401558; PMCID: PMC3587276.
    52. McKinney DM, Southwood S, Hinz D, Oseroff C, Arlehamn CS, Schulten V, Taplitz R, Broide D, Hanekom WA, Scriba TJ, Wood R, Alam R, Peters B, Sidney J, Sette A. A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population. Immunogenetics. 2013 May; 65(5):357-70. PMID: 23392739; PMCID: PMC3633633.
    53. Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson RS, Broide DH, Nizet V. Myeloid cell HIF-1a regulates asthma airway resistance and eosinophil function. J Mol Med (Berl). 2013 May; 91(5):637-44. PMID: 23250618.
      View in: PubMed
    54. Vaughan K, Peters B, Larche M, Pomes A, Broide D, Sette A. Strategies to query and display allergy-derived epitope data from the immune epitope database. Int Arch Allergy Immunol. 2013; 160(4):334-45. PMID: 23172234.
      View in: PubMed
    55. Schulten V, Oseroff C, Alam R, Broide D, Vijayanand P, Peters B, Sette A. The identification of potentially pathogenic and therapeutic epitopes from common human allergens. Ann Allergy Asthma Immunol. 2013 Jan; 110(1):7-10. PMID: 23244651; PMCID: PMC3547526.
    56. Miller M, Tam AB, Cho JY, Doherty TA, Pham A, Khorram N, Rosenthal P, Mueller JL, Hoffman HM, Suzukawa M, Niwa M, Broide DH. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16648-53. PMID: 23011799; PMCID: PMC3478632.
    57. Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Körner H, Cua DJ, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH, Matsumoto K, Nakae S. Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. J Immunol. 2012 Oct 01; 189(7):3641-52. PMID: 22942422; PMCID: PMC3812057.
    58. Doherty TA, Khorram N, Chang JE, Kim HK, Rosenthal P, Croft M, Broide DH. STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 01; 303(7):L577-88. PMID: 22865552; PMCID: PMC3469584.
    59. Oseroff C, Sidney J, Vita R, Tripple V, McKinney DM, Southwood S, Brodie TM, Sallusto F, Grey H, Alam R, Broide D, Greenbaum JA, Kolla R, Peters B, Sette A. T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts. J Immunol. 2012 Aug 15; 189(4):1800-11. PMID: 22786768; PMCID: PMC3411923.
    60. Oseroff C, Sidney J, Tripple V, Grey H, Wood R, Broide DH, Greenbaum J, Kolla R, Peters B, Pomés A, Sette A. Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production. J Immunol. 2012 Jul 15; 189(2):679-88. PMID: 22706084; PMCID: PMC3392449.
    61. Doherty TA, Khorram N, Sugimoto K, Sheppard D, Rosenthal P, Cho JY, Pham A, Miller M, Croft M, Broide DH. Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol. 2012 Mar 15; 188(6):2622-9. PMID: 22327070; PMCID: PMC3294141.
    62. Kashiwakura JC, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho MH, Zajonc DM, Ozeki T, Ra C, MacDonald SM, Siraganian RP, Broide DH, Kawakami Y, Kawakami T. Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy. J Clin Invest. 2012 Jan; 122(1):218-28. PMID: 22133880; PMCID: PMC3248297.
    63. Rubinstein E, Cho JY, Rosenthal P, Chao J, Miller M, Pham A, Aceves SS, Varki A, Broide DH. Siglec-F inhibition reduces esophageal eosinophilia and angiogenesis in a mouse model of eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2011 Oct; 53(4):409-16. PMID: 21970996; PMCID: PMC3980963.
    64. Doherty TA, Soroosh P, Khorram N, Fukuyama S, Rosenthal P, Cho JY, Norris PS, Choi H, Scheu S, Pfeffer K, Zuraw BL, Ware CF, Broide DH, Croft M. The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med. 2011 May; 17(5):596-603. PMID: 21499267; PMCID: PMC3097134.
    65. Cho JY, Pham A, Rosenthal P, Miller M, Doherty T, Broide DH. Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling. Int Immunopharmacol. 2011 Aug; 11(8):1038-44. PMID: 21382533; PMCID: PMC3121895.
    66. Broide DH, Finkelman F, Bochner BS, Rothenberg ME. Advances in mechanisms of asthma, allergy, and immunology in 2010. J Allergy Clin Immunol. 2011 Mar; 127(3):689-95. PMID: 21377038.
      View in: PubMed
    67. Vaughan K, Greenbaum J, Kim Y, Vita R, Chung J, Peters B, Broide D, Goodman R, Grey H, Sette A. Towards defining molecular determinants recognized by adaptive immunity in allergic disease: an inventory of the available data. J Allergy (Cairo). 2010; 2010:628026. PMID: 21403821; PMCID: PMC3042621.
    68. Ebmeyer J, Leichtle A, Hernandez M, Ebmeyer U, Husseman J, Pak K, Sudhoff H, Broide D, Wasserman SI, Ryan AF. TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media. BMC Immunol. 2011 Jan 26; 12:12. PMID: 21269505; PMCID: PMC3040143.
    69. Yum HY, Cho JY, Miller M, Broide DH. Allergen-induced coexpression of bFGF and TGF-ß1 by macrophages in a mouse model of airway remodeling: bFGF induces macrophage TGF-ß1 expression in vitro. Int Arch Allergy Immunol. 2011; 155(1):12-22. PMID: 21109744; PMCID: PMC2997445.
    70. Aceves SS, Chen D, Newbury RO, Dohil R, Bastian JF, Broide DH. Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-ß1, and increase esophageal smooth muscle contraction. J Allergy Clin Immunol. 2010 Dec; 126(6):1198-204.e4. PMID: 21047675.
      View in: PubMed
    71. Cho JY, Song DJ, Pham A, Rosenthal P, Miller M, Dayan S, Doherty TA, Varki A, Broide DH. Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13. Respir Res. 2010 Nov 01; 11:154. PMID: 21040544; PMCID: PMC2988013.
    72. Miller M, Cho JY, Pham A, Friedman PJ, Ramsdell J, Broide DH. Persistent airway inflammation and emphysema progression on CT scan in ex-smokers observed for 4 years. Chest. 2011 Jun; 139(6):1380-1387. PMID: 20966041; PMCID: PMC3109645.
    73. Miller M, Pham A, Cho JY, Rosenthal P, Broide DH. Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema. Am J Physiol Lung Cell Mol Physiol. 2010 Dec; 299(6):L834-42. PMID: 20935231; PMCID: PMC3006270.
    74. Broide DH. Allergic rhinitis: Pathophysiology. Allergy Asthma Proc. 2010 Sep-Oct; 31(5):370-4. PMID: 20929602.
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    75. Oseroff C, Sidney J, Kotturi MF, Kolla R, Alam R, Broide DH, Wasserman SI, Weiskopf D, McKinney DM, Chung JL, Petersen A, Grey H, Peters B, Sette A. Molecular determinants of T cell epitope recognition to the common Timothy grass allergen. J Immunol. 2010 Jul 15; 185(2):943-55. PMID: 20554959.
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    76. Pae S, Cho JY, Dayan S, Miller M, Pemberton AD, Broide DH. Chronic allergen challenge induces bronchial mast cell accumulation in BALB/c but not C57BL/6 mice and is independent of IL-9. Immunogenetics. 2010 Aug; 62(8):499-506. PMID: 20480160; PMCID: PMC2910299.
    77. Lee SY, Miller M, Cho JY, Song DJ, Karin M, Broide DH. Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation. Int Immunopharmacol. 2010 Aug; 10(8):906-12. PMID: 20494824; PMCID: PMC2908188.
    78. Takahashi H, Ogata H, Nishigaki R, Broide DH, Karin M. Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer Cell. 2010 Jan 19; 17(1):89-97. PMID: 20129250; PMCID: PMC2818776.
    79. Ebmeyer J, Ebmeyer U, Pak K, Sudhoff H, Broide D, Ryan AF, Wasserman S. Reconstitution of the mast cell population in W/Wv mice. Otol Neurotol. 2010 Jan; 31(1):42-7. PMID: 19752767; PMCID: PMC2796298.
    80. Turvey SE, Broide DH. Innate immunity. J Allergy Clin Immunol. 2010 Feb; 125(2 Suppl 2):S24-32. PMID: 19932920; PMCID: PMC2832725.
    81. Song DJ, Min MG, Miller M, Cho JY, Yum HY, Broide DH. Toll-like receptor-9 agonist inhibits airway inflammation, remodeling and hyperreactivity in mice exposed to chronic environmental tobacco smoke and allergen. Int Arch Allergy Immunol. 2010; 151(4):285-96. PMID: 19851071; PMCID: PMC2853586.
    82. Aceves SS, Newbury RO, Chen D, Mueller J, Dohil R, Hoffman H, Bastian JF, Broide DH. Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids. Allergy. 2010 Jan; 65(1):109-16. PMID: 19796194; PMCID: PMC2807896.
    83. Song DJ, Cho JY, Lee SY, Miller M, Rosenthal P, Soroosh P, Croft M, Zhang M, Varki A, Broide DH. Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling. J Immunol. 2009 Oct 15; 183(8):5333-41. PMID: 19783675; PMCID: PMC2788790.
    84. Song DJ, Min MG, Miller M, Cho JY, Broide DH. Environmental tobacco smoke exposure does not prevent corticosteroids reducing inflammation, remodeling, and airway hyperreactivity in mice exposed to allergen. Am J Physiol Lung Cell Mol Physiol. 2009 Aug; 297(2):L380-7. PMID: 19525386; PMCID: PMC2742786.
    85. Strangman WK, Kwon HC, Broide D, Jensen PR, Fenical W. Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium. J Med Chem. 2009 Apr 23; 52(8):2317-27. PMID: 19323483; PMCID: PMC2735501.
    86. Boyce JA, Broide D, Matsumoto K, Bochner BS. Advances in mechanisms of asthma, allergy, and immunology in 2008. J Allergy Clin Immunol. 2009 Mar; 123(3):569-74. PMID: 19281904; PMCID: PMC2671063.
    87. Song DJ, Cho JY, Miller M, Strangman W, Zhang M, Varki A, Broide DH. Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model. Clin Immunol. 2009 Apr; 131(1):157-69. PMID: 19135419; PMCID: PMC2683248.
    88. Broide DH. Immunomodulation of allergic disease. Annu Rev Med. 2009; 60:279-91. PMID: 19630573; PMCID: PMC2779001.
    89. Miller M, Cho JY, Pham A, Ramsdell J, Broide DH. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Immunol. 2009 Jan 01; 182(1):684-91. PMID: 19109202.
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    90. Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney DG, Webster NJ, Broide DH, Ryan AF, Wasserman SI. Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. J Infect Dis. 2008 Dec 15; 198(12):1862-9. PMID: 18986247; PMCID: PMC3584630.
    91. Doherty TA, Soroosh P, Broide DH, Croft M. CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling. Am J Physiol Lung Cell Mol Physiol. 2009 Feb; 296(2):L229-35. PMID: 19060225; PMCID: PMC2643996.
    92. Lim DH, Cho JY, Song DJ, Lee SY, Miller M, Broide DH. PI3K gamma-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling. Am J Physiol Lung Cell Mol Physiol. 2009 Feb; 296(2):L210-9. PMID: 19028980; PMCID: PMC2643991.
    93. Broide D. New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007. J Allergy Clin Immunol. 2008 Sep; 122(3):475-80. PMID: 18694589.
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    94. Aceves SS, Broide DH. Airway fibrosis and angiogenesis due to eosinophil trafficking in chronic asthma. Curr Mol Med. 2008 Aug; 8(5):350-8. PMID: 18691061.
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    95. Fong CH, Bebien M, Didierlaurent A, Nebauer R, Hussell T, Broide D, Karin M, Lawrence T. An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation. J Exp Med. 2008 Jun 09; 205(6):1269-76. PMID: 18490491; PMCID: PMC2413025.
    96. Broide DH. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol. 2008 Mar; 121(3):560-70; quiz 571-2. PMID: 18328887; PMCID: PMC2386668.
    97. Le Saux CJ, Teeters K, Miyasato SK, Hoffmann PR, Bollt O, Douet V, Shohet RV, Broide DH, Tam EK. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. J Biol Chem. 2008 Feb 29; 283(9):5760-8. PMID: 18056268.
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    98. Hayashi T, Mo JH, Gong X, Rossetto C, Jang A, Beck L, Elliott GI, Kufareva I, Abagyan R, Broide DH, Lee J, Raz E. 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18619-24. PMID: 18003900; PMCID: PMC2141826.
    99. Miller M, Ramsdell J, Friedman PJ, Cho JY, Renvall M, Broide DH. Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema. J Allergy Clin Immunol. 2007 Nov; 120(5):1118-25. PMID: 17983873.
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    100. Doherty T, Broide D. Cytokines and growth factors in airway remodeling in asthma. Curr Opin Immunol. 2007 Dec; 19(6):676-80. PMID: 17720466.
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    101. Broide DH. The pathophysiology of allergic rhinoconjunctivitis. Allergy Asthma Proc. 2007 Jul-Aug; 28(4):398-403. PMID: 17883906.
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    102. Le AV, Cho JY, Miller M, McElwain S, Golgotiu K, Broide DH. Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice. J Immunol. 2007 Jun 01; 178(11):7310-6. PMID: 17513781.
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    103. Min MG, Song DJ, Miller M, Cho JY, McElwain S, Ferguson P, Broide DH. Coexposure to environmental tobacco smoke increases levels of allergen-induced airway remodeling in mice. J Immunol. 2007 Apr 15; 178(8):5321-8. PMID: 17404317.
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    104. Zhang M, Angata T, Cho JY, Miller M, Broide DH, Varki A. Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood. 2007 May 15; 109(10):4280-7. PMID: 17272508; PMCID: PMC1885492.
    105. Aceves SS, Newbury RO, Dohil R, Bastian JF, Broide DH. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2007 Jan; 119(1):206-12. PMID: 17208603.
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    106. Creticos PS, Schroeder JT, Hamilton RG, Balcer-Whaley SL, Khattignavong AP, Lindblad R, Li H, Coffman R, Seyfert V, Eiden JJ, Broide D. Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med. 2006 Oct 05; 355(14):1445-55. PMID: 17021320.
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    107. Lim DH, Cho JY, Miller M, McElwain K, McElwain S, Broide DH. Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2006 Aug; 291(2):L265-71. PMID: 16825657.
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    108. Cho JY, Miller M, McElwain K, McElwain S, Shim JY, Raz E, Broide DH. Remodeling associated expression of matrix metalloproteinase 9 but not tissue inhibitor of metalloproteinase 1 in airway epithelium: modulation by immunostimulatory DNA. J Allergy Clin Immunol. 2006 Mar; 117(3):618-25. PMID: 16522462.
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    109. Le AV, Broide DH. Indoleamine-2,3-dioxygenase modulation of allergic immune responses. Curr Allergy Asthma Rep. 2006 Feb; 6(1):27-31. PMID: 16476191.
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    110. Lee SY, Cho JY, Miller M, McElwain K, McElwain S, Sriramarao P, Raz E, Broide DH. Immunostimulatory DNA inhibits allergen-induced peribronchial angiogenesis in mice. J Allergy Clin Immunol. 2006 Mar; 117(3):597-603. PMID: 16522459.
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    111. Broide DH. Prospects for CpG based immunotherapy in asthma and allergy. Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M. 2006; (95):217-20; discussion 220-2. PMID: 17393743.
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    112. Miller M, Cho JY, McElwain K, McElwain S, Shim JY, Manni M, Baek JS, Broide DH. Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice. Am J Physiol Lung Cell Mol Physiol. 2006 Jan; 290(1):L162-9. PMID: 16344333.
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    113. Broide DH, Lawrence T, Doherty T, Cho JY, Miller M, McElwain K, McElwain S, Karin M. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17723-8. PMID: 16317067; PMCID: PMC1308936.
    114. Cho JY, Miller M, McElwain K, McElwain S, Broide DH. Combination of corticosteroid therapy and allergen avoidance reverses allergen-induced airway remodeling in mice. J Allergy Clin Immunol. 2005 Nov; 116(5):1116-22. PMID: 16275385.
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    115. Ebmeyer J, Furukawa M, Pak K, Ebmeyer U, Sudhoff H, Broide D, Ryan AF, Wasserman S. Role of mast cells in otitis media. J Allergy Clin Immunol. 2005 Nov; 116(5):1129-35. PMID: 16275387.
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    116. Broide DH. DNA vaccines: an evolving approach to the treatment of allergic disorders. Allergy Asthma Proc. 2005 May-Jun; 26(3):195-8. PMID: 16119033.
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    117. Broide DH. Immunostimulatory sequences of DNA and conjugates in the treatment of allergic rhinitis. Curr Allergy Asthma Rep. 2005 May; 5(3):182-5. PMID: 15842954.
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    118. Hayashi T, Gong X, Rossetto C, Shen C, Takabayashi K, Redecke V, Spiegelberg H, Broide D, Raz E. Induction and inhibition of the Th2 phenotype spread: implications for childhood asthma. J Immunol. 2005 May 01; 174(9):5864-73. PMID: 15843591.
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    119. Youn CJ, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, McElwain K, McElwain S, Raz E, Broide DH. Immunostimulatory DNA reverses established allergen-induced airway remodeling. J Immunol. 2004 Dec 15; 173(12):7556-64. PMID: 15585883.
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    120. Broide D. Immunomodulation and reversal of airway remodeling in asthma. Curr Opin Allergy Clin Immunol. 2004 Dec; 4(6):529-32. PMID: 15640694.
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    121. Binder CJ, Hartvigsen K, Chang MK, Miller M, Broide D, Palinski W, Curtiss LK, Corr M, Witztum JL. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest. 2004 Aug; 114(3):427-37. PMID: 15286809; PMCID: PMC484976.
    122. Hayashi T, Beck L, Rossetto C, Gong X, Takikawa O, Takabayashi K, Broide DH, Carson DA, Raz E. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest. 2004 Jul; 114(2):270-9. PMID: 15254594; PMCID: PMC449749.
    123. Redecke V, Häcker H, Datta SK, Fermin A, Pitha PM, Broide DH, Raz E. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol. 2004 Mar 01; 172(5):2739-43. PMID: 14978071.
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    124. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, McElwain K, McElwain S, Friedman S, Broide DH. Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest. 2004 Feb; 113(4):551-60. PMID: 14966564; PMCID: PMC338264.
    125. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Rodriguez M, Lee SY, McElwain K, McElwain S, Raz E, Broide DH. Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling. Am J Respir Cell Mol Biol. 2004 May; 30(5):651-61. PMID: 14617508.
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    126. Ikeda RK, Miller M, Nayar J, Walker L, Cho JY, McElwain K, McElwain S, Raz E, Broide DH. Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences. J Immunol. 2003 Nov 01; 171(9):4860-7. PMID: 14568966.
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    127. Holgate ST, Broide D. New targets for allergic rhinitis--a disease of civilization. Nat Rev Drug Discov. 2003 Nov; 2(11):902-14. PMID: 14668811.
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    128. Ikeda RK, Nayar J, Cho JY, Miller M, Rodriguez M, Raz E, Broide DH. Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids. Am J Respir Cell Mol Biol. 2003 Jun; 28(6):655-63. PMID: 12760963.
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    129. Sikora L, Johansson AC, Rao SP, Hughes GK, Broide DH, Sriramarao P. A murine model to study leukocyte rolling and intravascular trafficking in lung microvessels. Am J Pathol. 2003 Jun; 162(6):2019-28. PMID: 12759257; PMCID: PMC1868130.
    130. Hoffman HM, Gregory SG, Mueller JL, Tresierras M, Broide DH, Wanderer AA, Kolodner RD. Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P. Hum Genet. 2003 Feb; 112(2):209-16. PMID: 12522564.
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    131. Khaldoyanidi S, Sikora L, Broide DH, Rothenberg ME, Sriramarao P. Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen. Blood. 2003 Feb 01; 101(3):863-8. PMID: 12393708.
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    132. Miller M, Cho JY, Baek KJ, Castaneda D, Nayar J, Rodriguez M, Roman M, Raz E, Broide DH. Plasmid DNA encoding the respiratory syncytial virus G protein protects against RSV-induced airway hyperresponsiveness. Vaccine. 2002 Jul 26; 20(23-24):3023-33. PMID: 12126916.
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    133. Broide D. Fast flowing eosinophils: signals for stopping and stepping out of blood vessels. Am J Respir Cell Mol Biol. 2002 Jun; 26(6):637-40. PMID: 12034560.
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    134. Broide DH, Miller M, Castaneda D, Nayar J, Cho JY, Roman M, Ellies LG, Sriramarao P. Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment. Am J Physiol Lung Cell Mol Physiol. 2002 Feb; 282(2):L259-66. PMID: 11792630.
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    135. Broide D, Malling HJ. Immunologic treatment of allergic diseases. Curr Opin Allergy Clin Immunol. 2001 Dec; 1(6):541-3. PMID: 11964738.
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    136. Cho JY, Miller M, Baek KJ, Castaneda D, Nayar J, Roman M, Raz E, Broide DH. Immunostimulatory DNA sequences inhibit respiratory syncytial viral load, airway inflammation, and mucus secretion. J Allergy Clin Immunol. 2001 Nov; 108(5):697-702. PMID: 11692091.
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    137. Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet. 2001 Nov; 29(3):301-5. PMID: 11687797; PMCID: PMC4322000.
    138. Broide DH, Stachnick G, Castaneda D, Nayar J, Miller M, Cho J, Rodriquez M, Roman M, Raz E. Immunostimulatory DNA mediates inhibition of eosinophilic inflammation and airway hyperreactivity independent of natural killer cells in vivo. J Allergy Clin Immunol. 2001 Nov; 108(5):759-63. PMID: 11692101.
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    139. Hoffman HM, Wanderer AA, Broide DH. Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever. J Allergy Clin Immunol. 2001 Oct; 108(4):615-20. PMID: 11590390; PMCID: PMC4321996.
    140. Miller M, Sung KL, Muller WA, Cho JY, Roman M, Castaneda D, Nayar J, Condon T, Kim J, Sriramarao P, Broide DH. Eosinophil tissue recruitment to sites of allergic inflammation in the lung is platelet endothelial cell adhesion molecule independent. J Immunol. 2001 Aug 15; 167(4):2292-7. PMID: 11490017.
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    141. Broide DH. Molecular and cellular mechanisms of allergic disease. J Allergy Clin Immunol. 2001 Aug; 108(2 Suppl):S65-71. PMID: 11498675.
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    142. Broide DH, Stachnick G, Castaneda D, Nayar J, Miller M, Cho JY, Roman M, Zubeldia J, Hayashi T, Raz E, Hyashi T. Systemic administration of immunostimulatory DNA sequences mediates reversible inhibition of Th2 responses in a mouse model of asthma. J Clin Immunol. 2001 May; 21(3):175-82. PMID: 11403224.
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    143. Berin MC, Eckmann L, Broide DH, Kagnoff MF. Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts. Am J Respir Cell Mol Biol. 2001 Apr; 24(4):382-9. PMID: 11306430.
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    144. Broide DH, Stachnick G, Castaneda D, Nayar J, Sriramarao P. Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice. Am J Respir Cell Mol Biol. 2001 Mar; 24(3):304-11. PMID: 11245629.
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    145. Broide D, Sriramarao P. Eosinophil trafficking to sites of allergic inflammation. Immunol Rev. 2001 Feb; 179:163-72. PMID: 11292020.
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    146. Horner AA, Van Uden JH, Zubeldia JM, Broide D, Raz E. DNA-based immunotherapeutics for the treatment of allergic disease. Immunol Rev. 2001 Feb; 179:102-18. PMID: 11292014.
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    147. Sung KP, Yang L, Kim J, Ko D, Stachnick G, Castaneda D, Nayar J, Broide DH. Eotaxin induces a sustained reduction in the functional adhesive state of very late antigen 4 for the connecting segment 1 region of fibronectin. J Allergy Clin Immunol. 2000 Nov; 106(5):933-40. PMID: 11080717.
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    148. Hoffman HM, Wright FA, Broide DH, Wanderer AA, Kolodner RD. Identification of a locus on chromosome 1q44 for familial cold urticaria. Am J Hum Genet. 2000 May; 66(5):1693-8. PMID: 10741953; PMCID: PMC1378006.
    149. Sriramarao P, DiScipio RG, Cobb RR, Cybulsky M, Stachnick G, Castaneda D, Elices M, Broide DH. VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow. Blood. 2000 Jan 15; 95(2):592-601. PMID: 10627468.
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    150. Broide D, Cho JY, Miller M, Nayar J, Stachnick G, Castaneda D, Roman M, Raz E. Modulation of asthmatic response by immunostimulatory DNA sequences. Springer Semin Immunopathol. 2000; 22(1-2):117-24. PMID: 10944806.
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    151. Roman M, Tighe H, Spiegelberg HL, Broide D, Raz E. Genetic immunization for allergy immunotherapy. Methods Mol Med. 2000; 29:451-72. PMID: 21374341.
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    152. Broide DH, Campbell K, Gifford T, Sriramarao P. Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium. Blood. 2000 Jan 01; 95(1):263-9. PMID: 10607711.
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    153. Broide DH, Hoffman H, Sriramarao P. Genes that regulate eosinophilic inflammation. Am J Hum Genet. 1999 Aug; 65(2):302-7. PMID: 10417272; PMCID: PMC1377928.
    154. Broide D, Raz E. DNA-Based immunization for asthma. Int Arch Allergy Immunol. 1999 Feb-Apr; 118(2-4):453-6. PMID: 10224473.
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    155. DiScipio RG, Daffern PJ, Jagels MA, Broide DH, Sriramarao P. A comparison of C3a and C5a-mediated stable adhesion of rolling eosinophils in postcapillary venules and transendothelial migration in vitro and in vivo. J Immunol. 1999 Jan 15; 162(2):1127-36. PMID: 9916743.
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    156. Spiegelberg HL, Broide D, Tighe H, Roman M, Raz E. Inhibition of allergic inflammation in the lung by plasmid DNA allergen immunization. Pediatr Pulmonol Suppl. 1999; 18:118-21. PMID: 10093118.
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    157. Broide D, Schwarze J, Tighe H, Gifford T, Nguyen MD, Malek S, Van Uden J, Martin-Orozco E, Gelfand EW, Raz E. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J Immunol. 1998 Dec 15; 161(12):7054-62. PMID: 9862743.
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    158. Horner AA, Ronaghy A, Cheng PM, Nguyen MD, Cho HJ, Broide D, Raz E. Immunostimulatory DNA is a potent mucosal adjuvant. Cell Immunol. 1998 Nov 25; 190(1):77-82. PMID: 9826449.
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    159. Goodman JS, Van Uden JH, Kobayashi H, Broide D, Raz E. DNA immunotherapeutics: new potential treatment modalities for allergic disease. Int Arch Allergy Immunol. 1998 Jul; 116(3):177-87. PMID: 9693265.
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    160. Broide DH, Humber D, Sullivan S, Sriramarao P. Inhibition of eosinophil rolling and recruitment in P-selectin- and intracellular adhesion molecule-1-deficient mice. Blood. 1998 Apr 15; 91(8):2847-56. PMID: 9531595.
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    161. Broide DH, Sullivan S, Gifford T, Sriramarao P. Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice. Am J Respir Cell Mol Biol. 1998 Feb; 18(2):218-25. PMID: 9476909.
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    162. Spiegelberg HL, Tighe H, Roman M, Broide D, Raz E. Inhibition of IgE formation and allergic inflammation by allergen gene immunization and by CpG motif immunostimulatory oligodeoxynucleotides. Allergy. 1998; 53(45 Suppl):93-7. PMID: 9788716.
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    163. Sung KL, Li Y, Elices M, Gang J, Sriramarao P, Broide DH. Granulocyte-macrophage colony-stimulating factor regulates the functional adhesive state of very late antigen-4 expressed by eosinophils. J Immunol. 1997 Jan 15; 158(2):919-27. PMID: 8993012.
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    164. Roman M, Spiegelberg HL, Broide D, Raz E. Gene immunization for allergic disorders. Springer Semin Immunopathol. 1997; 19(2):223-32. PMID: 9406348.
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    165. Sriramarao P, Norton CR, Borgstrom P, DiScipio RG, Wolitzky BA, Broide DH. E-selectin preferentially supports neutrophil but not eosinophil rolling under conditions of flow in vitro and in vivo. J Immunol. 1996 Nov 15; 157(10):4672-80. PMID: 8906848.
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    166. Sriramarao P, Broide DH. Differential regulation of eosinophil adhesion under conditions of flow in vivo. Ann N Y Acad Sci. 1996 Oct 31; 796:218-25. PMID: 8906229.
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    167. Sullivan S, Broide DH. Compartmentalization of eosinophil granulocyte-macrophage colony-stimulating factor expression in patients with asthma. J Allergy Clin Immunol. 1996 Apr; 97(4):966-76. PMID: 8655893.
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    168. Sriramarao P, Anderson W, Wolitzky BA, Broide DH. Mouse bone marrow-derived mast cells roll on P-selectin under conditions of flow in vivo. Lab Invest. 1996 Mar; 74(3):634-43. PMID: 8600314.
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    169. Anderson WH, Davidson TM, Broide DH. Mast cell TNF mRNA expression in nasal mucosa demonstrated by in situ hybridization: a comparison of mast cell detection methods. J Immunol Methods. 1996 Feb 05; 189(2):145-55. PMID: 8613667.
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    170. Weinberger MS, Davidson TM, Broide DH. Differential expression of vascular cell adhesion molecule mRNA and protein in nasal mucosa in response to IL-1 or tumor necrosis factor. J Allergy Clin Immunol. 1996 Feb; 97(2):662-71. PMID: 8621852.
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    171. Sur S, Gleich GJ, Swanson MC, Bartemes KR, Broide DH. Eosinophilic inflammation is associated with elevation of interleukin-5 in the airways of patients with spontaneous symptomatic asthma. J Allergy Clin Immunol. 1995 Nov; 96(5 Pt 1):661-8. PMID: 7499683.
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    172. Broide DH. Alpha 4 integrin-induced cytokine production and eosinophil function. Springer Semin Immunopathol. 1995; 16(4):405-15. PMID: 7570291.
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    173. Ferguson P, Broide DH. Environmental and bronchoalveolar lavage Dermatophagoides pteronyssinus antigen levels in atopic asthmatics. Am J Respir Crit Care Med. 1995 Jan; 151(1):71-4. PMID: 7812575.
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    174. Sriramarao P, von Andrian UH, Butcher EC, Bourdon MA, Broide DH. L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo. J Immunol. 1994 Nov 01; 153(9):4238-46. PMID: 7523519.
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    175. Sullivan S, Salapow MA, Breen R, Broide DH. Eosinophil peroxidase differs from neutrophil myeloperoxidase in its ability to bind antineutrophil cytoplasmic antibodies reactive with myeloperoxidase. Int Arch Allergy Immunol. 1994 Oct; 105(2):150-4. PMID: 7920015.
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    176. Broide DH, Paine MM, Firestein GS. Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest. 1992 Oct; 90(4):1414-24. PMID: 1401075; PMCID: PMC443187.
    177. Broide DH, Lotz M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol. 1992 May; 89(5):958-67. PMID: 1374772.
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    178. Wasserman SI, Broide DH, Marquardt DL. Cetirizine therapy for seasonal allergic rhinitis: alternative dosage schedules. Clin Ther. 1991 Nov-Dec; 13(6):707-13. PMID: 1686422.
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    179. Broide DH, Gleich GJ, Cuomo AJ, Coburn DA, Federman EC, Schwartz LB, Wasserman SI. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J Allergy Clin Immunol. 1991 Oct; 88(4):637-48. PMID: 1717532.
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    180. Broide DH, Firestein GS. Endobronchial allergen challenge in asthma. Demonstration of cellular source of granulocyte macrophage colony-stimulating factor by in situ hybridization. J Clin Invest. 1991 Sep; 88(3):1048-53. PMID: 1885766; PMCID: PMC295519.
    181. Broide DH, Smith CM, Wasserman SI. Mast cells and pulmonary fibrosis. Identification of a histamine releasing factor in bronchoalveolar lavage fluid. J Immunol. 1990 Sep 15; 145(6):1838-44. PMID: 1697311.
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    182. Broide DH, Eisman S, Ramsdell JW, Ferguson P, Schwartz LB, Wasserman SI. Airway levels of mast cell-derived mediators in exercise-induced asthma. Am Rev Respir Dis. 1990 Mar; 141(3):563-8. PMID: 1689974.
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    183. Broide DH, Wasserman SI, Alvaro-Gracia J, Zvaifler NJ, Firestein GS. Transforming growth factor-beta 1 selectively inhibits IL-3-dependent mast cell proliferation without affecting mast cell function or differentiation. J Immunol. 1989 Sep 01; 143(5):1591-7. PMID: 2527268.
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    184. Wasserman SI, Marquardt DL, Broide D, Walker L, Barrett K. Characterization, activation, and functional importance of mucosal mast cells. Prog Clin Biol Res. 1989; 297:155-61; discussion 161. PMID: 2685819.
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    185. Broide DH, Metcalfe DD, Wasserman SI. Functional and biochemical characterization of rat bone marrow derived mast cells. J Immunol. 1988 Dec 15; 141(12):4298-305. PMID: 2974057.
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    186. Firestein GS, Xu WD, Townsend K, Broide D, Alvaro-Gracia J, Glasebrook A, Zvaifler NJ. Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J Exp Med. 1988 Nov 01; 168(5):1573-86. PMID: 3263464; PMCID: PMC2189111.
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