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Shigeki Miyamoto

Title(s)Associate Adjunct Professor, Pharmacology
SchoolHealth Sciences
Address9500 Gilman Drive #0636
La Jolla CA 92093
Phone858-534-1368
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    Collapse Biography 
    Collapse Education and Training
    University of TokyoPh.D.

    Collapse Overview 

    Collapse Research 
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    Cardiomyocyte CaM kinase II as a driver of cardiac inflammation and remodeling
    NIH/NHLBI R01HL145459Dec 15, 2018 - Nov 30, 2022
    Role: Co-Principal Investigator
    Hexokinase-II protects the heart against ischemia through regulation of autophagy
    NIH/NHLBI R56HL097037Sep 4, 2015 - Aug 31, 2016
    Role: Principal Investigator
    Mitochondrial Protection by Hexokinase-II and Akt in the Heart
    NIH/NHLBI R01HL097037Aug 1, 2009 - Jun 30, 2014
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dissociation of mitochondrial HK-II elicits mitophagy and confers cardioprotection against ischemia. Cell Death Dis. 2019 09 30; 10(10):730. Tan VP, Smith JM, Tu M, Yu JD, Ding EY, Miyamoto S. PMID: 31570704.
      View in: PubMed   Mentions: 2     Fields:    
    2. Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling. Am J Physiol Heart Circ Physiol. 2019 11 01; 317(5):H877-H890. Suetomi T, Miyamoto S, Brown JH. PMID: 31441689.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis. Front Immunol. 2019; 10:1743. de Oliveira PG, Farinon M, Sanchez-Lopez E, Miyamoto S, Guma M. PMID: 31428089.
      View in: PubMed   Mentions: 1     Fields:    
    4. Autophagy and cardiac aging. Cell Death Differ. 2019 03; 26(4):653-664. Miyamoto S. PMID: 30692640.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload. J Biol Chem. 2019 03 08; 294(10):3603-3617. Byun J, Del Re DP, Zhai P, Ikeda S, Shirakabe A, Mizushima W, Miyamoto S, Brown JH, Sadoshima J. PMID: 30635403.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca2+/Calmodulin-Dependent Protein Kinase II d Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling. Circulation. 2018 11 27; 138(22):2530-2544. Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S, Brown JH. PMID: 30571348.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis. Ann Rheum Dis. 2018 11; 77(11):1636-1643. Bustamante MF, Oliveira PG, Garcia-Carbonell R, Croft AP, Smith JM, Serrano RL, Sanchez-Lopez E, Liu X, Kisseleva T, Hay N, Buckley CD, Firestein GS, Murphy AN, Miyamoto S, Guma M. PMID: 30061164.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes. Cell Signal. 2018 Oct; 50:48-57. Brand CS, Tan VP, Brown JH, Miyamoto S. PMID: 29953931.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    9. CaMKIId-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis. JCI Insight. 2018 06 21; 3(12). Willeford A, Suetomi T, Nickle A, Hoffman HM, Miyamoto S, Heller Brown J. PMID: 29925681.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. PMID: 29887596.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    11. [Hexokinase 2 mediated cellular protection: interaction with Akt/mTORC1 to regulate mitochondrial protection and autophagy]. Seikagaku. 2017 Apr; 89(2):199-210. Miyamoto S. PMID: 29624985.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells. Cell Death Discov. 2017; 3:16103. Xiong X, Wen YA, Mitov MI, C Oaks M, Miyamoto S, Gao T. PMID: 28179998.
      View in: PubMed   Mentions:
    13. CaMKIId subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-?B and TNF-a. J Mol Cell Cardiol. 2017 02; 103:48-55. Gray CB, Suetomi T, Xiang S, Mishra S, Blackwood EA, Glembotski CC, Miyamoto S, Westenbrink BD, Brown JH. PMID: 28077321.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. J Mol Cell Cardiol. 2017 02; 103:1-10. Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell NH, Brown JH, Miyamoto S. PMID: 28017639.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    15. Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload. Circulation. 2016 Mar 29; 133(13):1225-7. Miyamoto S, Brown JH. PMID: 26915632.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Evaluating mitochondrial autophagy in the mouse heart. J Mol Cell Cardiol. 2016 Mar; 92:134-9. Shirakabe A, Fritzky L, Saito T, Zhai P, Miyamoto S, Gustafsson ÅB, Kitsis RN, Sadoshima J. PMID: 26868976.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals. J Mol Cell Cardiol. 2016 06; 95:31-41. Tan VP, Miyamoto S. PMID: 26773603.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    18. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. PMID: 26799652.
      View in: PubMed   Mentions: 1209     Fields:    Translation:HumansAnimals
    19. Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation. Mol Cell Biol. 2016 Jan 01; 36(1):39-49. Yu OM, Miyamoto S, Brown JH. PMID: 26459764.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    20. Cellular redox status determines sensitivity to BNIP3-mediated cell death in cardiac myocytes. Am J Physiol Cell Physiol. 2015 Jun 15; 308(12):C983-92. Lee Y, Kubli DA, Hanna RA, Cortez MQ, Lee HY, Miyamoto S, Gustafsson ÅB. PMID: 25810259.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    21. Mitochondrial reprogramming induced by CaMKIId mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39. Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. PMID: 25605649.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    22. HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection. Autophagy. 2015; 11(6):963-4. Tan VP, Miyamoto S. PMID: 26075878.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    23. Covalent modification of the NF-?B essential modulator (NEMO) by a chemical compound can regulate its ubiquitin binding properties in vitro. J Biol Chem. 2014 Nov 28; 289(48):33161-74. Hooper C, Jackson SS, Coughlin EE, Coon JJ, Miyamoto S. PMID: 25296760.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-?B signaling. Exp Cell Res. 2015 Feb 01; 331(1):58-72. Jackson SS, Oberley C, Hooper CP, Grindle K, Wuerzberger-Davis S, Wolff J, McCool K, Rui L, Miyamoto S. PMID: 25304104.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. PMID: 25236710.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    26. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. J Mol Cell Cardiol. 2014 Oct; 75:152-61. Zhao X, Ding EY, Yu OM, Xiang SY, Tan-Sah VP, Yung BS, Hedgpeth J, Neubig RR, Lau LF, Brown JH, Miyamoto S. PMID: 25106095.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    27. DEAD-box helicase DP103 defines metastatic potential of human breast cancers. J Clin Invest. 2014 Sep; 124(9):3807-24. Shin EM, Hay HS, Lee MH, Goh JN, Tan TZ, Sen YP, Lim SW, Yousef EM, Ong HT, Thike AA, Kong X, Wu Z, Mendoz E, Sun W, Salto-Tellez M, Lim CT, Lobie PE, Lim YP, Yap CT, Zeng Q, Sethi G, Lee MB, Tan P, Goh BC, Miller LD, Thiery JP, Zhu T, Gaboury L, Tan PH, Hui KM, Yip GW, Miyamoto S, Kumar AP, Tergaonkar V. PMID: 25083991.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    28. A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through NF-?B activation. PLoS One. 2014; 9(2):e88052. Yang B, Wagner J, Damaschke N, Yao T, Wuerzberger-Davis SM, Lee MH, Svaren J, Miyamoto S, Jarrard DF. PMID: 24558376.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    29. Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition. Mol Cell. 2014 Feb 20; 53(4):521-33. Roberts DJ, Tan-Sah VP, Ding EY, Smith JM, Miyamoto S. PMID: 24462113.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    30. PLCe, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. Sci Signal. 2013 Dec 17; 6(306):ra108. Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Heller Brown J. PMID: 24345679.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    31. Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes. J Biol Chem. 2013 Aug 16; 288(33):23798-806. Roberts DJ, Tan-Sah VP, Smith JM, Miyamoto S. PMID: 23836898.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    32. Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure. Genes Dev. 2013 Jun 15; 27(12):1365-77. Thomas RL, Roberts DJ, Kubli DA, Lee Y, Quinsay MN, Owens JB, Fischer KM, Sussman MA, Miyamoto S, Gustafsson ÅB. PMID: 23788623.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    33. Conference report from the 2012 AHA scientific sessions in Los Angeles. Expert Opin Ther Targets. 2013 Jun; 17(6):733-7. Westenbrink BD, Edwards AG, Miyamoto S. PMID: 23642039.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    34. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res. 2011 Dec 09; 109(12):1354-62. Mishra S, Gray CB, Miyamoto S, Bers DM, Brown JH. PMID: 21998325.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    35. NF-?B induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell. 2011 Jul 22; 43(2):180-91. Lee MH, Mabb AM, Gill GB, Yeh ET, Miyamoto S. PMID: 21777808.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    36. RhoA protects the mouse heart against ischemia/reperfusion injury. J Clin Invest. 2011 Aug; 121(8):3269-76. Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, Brown JH. PMID: 21747165.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    37. A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. Mol Cell Biol. 2011 Jul; 31(14):2774-86. Yang Y, Xia F, Hermance N, Mabb A, Simonson S, Morrissey S, Gandhi P, Munson M, Miyamoto S, Kelliher MA. PMID: 21606198.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    38. IKKß regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells. PLoS One. 2011 Apr 07; 6(4):e18447. Wu L, Shao L, An N, Wang J, Pazhanisamy S, Feng W, Hauer-Jensen M, Miyamoto S, Zhou D. PMID: 21490922.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    39. ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. Mol Cell. 2010 Oct 08; 40(1):75-86. Wu ZH, Wong ET, Shi Y, Niu J, Chen Z, Miyamoto S, Tergaonkar V. PMID: 20932476.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    40. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 2010 Aug; 120(8):2805-16. Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G. PMID: 20644257.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    41. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res. 2010 Aug 20; 107(4):476-84. Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PMID: 20576936.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    42. Revisited and revised: is RhoA always a villain in cardiac pathophysiology? J Cardiovasc Transl Res. 2010 Aug; 3(4):330-43. Miyamoto S, Del Re DP, Xiang SY, Zhao X, Florholmen G, Brown JH. PMID: 20559774.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    43. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res. 2010 Apr 16; 106(7):1265-74. Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA. PMID: 20203306.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    44. TAK-ling IKK activation: "Ub" the judge. Sci Signal. 2010 Jan 19; 3(105):pe3. Wuerzberger-Davis SM, Miyamoto S. PMID: 20086238.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    45. A PAR-SUMOnious mechanism of NEMO activation. Mol Cell. 2009 Nov 13; 36(3):349-50. McCool K, Miyamoto S. PMID: 19917242.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    46. Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J Bioenerg Biomembr. 2009 Apr; 41(2):169-80. Miyamoto S, Murphy AN, Brown JH. PMID: 19377835.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    47. Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc Res. 2009 May 01; 82(2):272-85. Miyamoto S, Rubio M, Sussman MA. PMID: 19279164.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    48. Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. J Mol Cell Cardiol. 2009 Jul; 47(1):96-103. Rubio M, Avitabile D, Fischer K, Emmanuel G, Gude N, Miyamoto S, Mishra S, Schaefer EM, Brown JH, Sussman MA. PMID: 19269295.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    49. Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J Biol Chem. 2008 Dec 19; 283(51):35622-9. Del Re DP, Miyamoto S, Brown JH. PMID: 18854312.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    50. Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress. EMBO J. 2008 Jul 23; 27(14):1963-73. Wu ZH, Miyamoto S. PMID: 18583959.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    51. Group B streptococcal beta-hemolysin/cytolysin directly impairs cardiomyocyte viability and function. PLoS One. 2008 Jun 18; 3(6):e2446. Hensler ME, Miyamoto S, Nizet V. PMID: 18560574.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    52. Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo. J Immunol. 2008 Jun 01; 180(11):7107-11. Ni CY, Wu ZH, Florence WC, Parekh VV, Arrate MP, Pierce S, Schweitzer B, Van Kaer L, Joyce S, Miyamoto S, Ballard DW, Oltz EM. PMID: 18490708.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    53. S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. J Biol Chem. 2008 May 02; 283(18):11954-63. Means CK, Miyamoto S, Chun J, Brown JH. PMID: 18296752.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    54. RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. J Biol Chem. 2007 Mar 16; 282(11):8069-78. Del Re DP, Miyamoto S, Brown JH. PMID: 17234627.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    55. Calcium-dependent regulation of NEMO nuclear export in response to genotoxic stimuli. Mol Cell Biol. 2007 Jan; 27(2):497-509. Berchtold CM, Wu ZH, Huang TT, Miyamoto S. PMID: 17074802.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    56. Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science. 2006 Feb 24; 311(5764):1141-6. Wu ZH, Shi Y, Tibbetts RS, Miyamoto S. PMID: 16497931.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansCells
    57. Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy. J Mol Cell Cardiol. 2006 May; 40(5):597-604. Howes AL, Miyamoto S, Adams JW, Woodcock EA, Brown JH. PMID: 16466740.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    58. Nuclear factor-kappaB dimer exchange promotes a p21(waf1/cip1) superinduction response in human T leukemic cells. Mol Cancer Res. 2006 Feb; 4(2):101-12. Chang PY, Miyamoto S. PMID: 16513841.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    59. Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. J Biol Chem. 2005 Nov 18; 280(46):38505-12. Miyamoto S, Howes AL, Adams JW, Dorn GW, Brown JH. PMID: 16061478.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    60. Enhanced G2-M arrest by nuclear factor-{kappa}B-dependent p21waf1/cip1 induction. Mol Cancer Res. 2005 Jun; 3(6):345-53. Wuerzberger-Davis SM, Chang PY, Berchtold C, Miyamoto S. PMID: 15972853.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    61. Evidence for a phosphorylation-independent role for Ser 32 and 36 in proteasome inhibitor-resistant (PIR) IkappaBalpha degradation in B cells. Exp Cell Res. 2005 Jul 01; 307(1):15-25. O'Connor S, Markovina S, Miyamoto S. PMID: 15922723.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    62. Inhibition of IkappaBalpha nuclear export as an approach to abrogate nuclear factor-kappaB-dependent cancer cell survival. Mol Cancer Res. 2005 Jan; 3(1):42-9. O'Connor S, Shumway S, Miyamoto S. PMID: 15671248.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    63. Effects of SEA0400, a Na+/Ca2+ exchange inhibitor, on ventricular arrhythmias in the in vivo dogs. Eur J Pharmacol. 2005 Jan 04; 506(3):249-55. Nagasawa Y, Zhu BM, Chen J, Kamiya K, Miyamoto S, Hashimoto K. PMID: 15627435.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    64. Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells. Mol Cell Biol. 2004 Jun; 24(11):4895-908. O'Connor S, Shumway SD, Amanna IJ, Hayes CE, Miyamoto S. PMID: 15143182.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    65. A mechanistic insight into a proteasome-independent constitutive inhibitor kappaBalpha (IkappaBalpha) degradation and nuclear factor kappaB (NF-kappaB) activation pathway in WEHI-231 B-cells. Biochem J. 2004 May 15; 380(Pt 1):173-80. Shumway SD, Miyamoto S. PMID: 14763901.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    66. RelA life and death decisions. Mol Cell. 2004 Mar 26; 13(6):763-4. Miyamoto S. PMID: 15053867.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    67. Cardiomyocyte calcium and calcium/calmodulin-dependent protein kinase II: friends or foes? Recent Prog Horm Res. 2004; 59:141-68. Zhang T, Miyamoto S, Brown JH. PMID: 14749501.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    68. Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell. 2003 Nov 26; 115(5):565-76. Huang TT, Wuerzberger-Davis SM, Wu ZH, Miyamoto S. PMID: 14651848.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimalsCells
    69. Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation. Oncogene. 2003 Sep 01; 22(37):5813-27. Criswell T, Leskov K, Miyamoto S, Luo G, Boothman DA. PMID: 12947388.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    70. Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. J Biol Chem. 2003 Oct 10; 278(41):40343-51. Howes AL, Arthur JF, Zhang T, Miyamoto S, Adams JW, Dorn GW, Woodcock EA, Brown JH. PMID: 12900409.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    71. Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation. J Biol Chem. 2003 Aug 15; 278(33):31111-7. Kawamura S, Miyamoto S, Brown JH. PMID: 12777392.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    72. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003 May 02; 92(8):912-9. Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J, Bers DM, Brown JH. PMID: 12676814.
      View in: PubMed   Mentions: 188     Fields:    Translation:AnimalsCells
    73. The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors. Mol Cell Biol. 2002 Aug; 22(16):5813-25. Huang TT, Feinberg SL, Suryanarayanan S, Miyamoto S. PMID: 12138192.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    74. CD14-dependent activation of NF-kappaB by filarial parasitic sheath proteins. Cell Biol Int. 2002; 26(1):43-54. Narayanan K, Seufzer BJ, Brockman-Schneider RA, Gern JE, Balakrishnan A, Miyamoto S. PMID: 11779220.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    75. Inhibitory effects of pre-ischemic and post-ischemic treatment with FR 168888, a Na+/H+ exchange inhibitor, on reperfusion-induced ventricular arrhythmias in anesthetized rat. Jpn J Pharmacol. 2002 Jan; 88(1):93-9. Zhu BM, Miyamoto S, Kamiya K, Komori S, Hashimoto K. PMID: 11855683.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    76. Evidence for unique calmodulin-dependent nuclear factor-kappaB regulation in WEHI-231 B cells. Mol Pharmacol. 2002 Jan; 61(1):177-85. Shumway SD, Berchtold CM, Gould MN, Miyamoto S. PMID: 11752219.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
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