Shigeki Miyamoto

Title(s)Adjunct Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of TokyoPh.D.

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Cardiomyocyte CaM kinase II as a driver of cardiac inflammation and remodeling
    NIH R01HL145459Dec 15, 2018 - Nov 30, 2022
    Role: Co-Principal Investigator
    Hexokinase-II protects the heart against ischemia through regulation of autophagy
    NIH R56HL097037Sep 4, 2015 - Aug 31, 2018
    Role: Principal Investigator
    Mitochondrial Protection by Hexokinase-II and Akt in the Heart
    NIH R01HL097037Aug 1, 2009 - Apr 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion. Sci Rep. 2023 12 16; 13(1):22412. Chaim OM, Miki S, Prager BC, Ma J, Jeong AY, Lara J, Tran NK, Smith JM, Rich JN, Gutkind JS, Miyamoto S, Furnari FB, Brown JH. PMID: 38104152; PMCID: PMC10725435.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Role of mitochondria-bound HK2 in rheumatoid arthritis fibroblast-like synoviocytes. Front Immunol. 2023; 14:1103231. Torres A, Kang S, Mahony CB, Cedeño M, Oliveira PG, Fernandez-Bustamante M, Kemble S, Laragione T, Gulko PS, Croft AP, Sanchez-Lopez E, Miyamoto S, Guma M. PMID: 37529037; PMCID: PMC10389265.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Hippo signaling pathway and mitochondrial dysfunction in Takotsubo syndrome. Am J Physiol Heart Circ Physiol. 2023 04 01; 324(4):H525-H527. Miyamoto S. PMID: 36800511.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. RHOA, a small G-protein, signals to mitophagy through regulation of PINK1 protein stability and protects cardiomyocytes against ischemia. Autophagy. 2023 06; 19(6):1865-1866. Tu M, Miyamoto S. PMID: 36201460; PMCID: PMC10262781.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria. Cell Death Differ. 2022 12; 29(12):2472-2486. Tu M, Tan VP, Yu JD, Tripathi R, Bigham Z, Barlow M, Smith JM, Brown JH, Miyamoto S. PMID: 35760846; PMCID: PMC9751115.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Splicing and Dicing: A Deeper Dive Into CaMKIIδ and Cardiac Inflammation. Circ Res. 2022 03 18; 130(6):904-906. Brown JH, Miyamoto S. PMID: 35298299; PMCID: PMC8944245.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger. Cells. 2021 11 27; 10(12). Yu JD, Miyamoto S. PMID: 34943839; PMCID: PMC8699551.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification. J Am Heart Assoc. 2021 02 16; 10(4):e019019. Calcagno DM, Zhang C, Toomu A, Huang K, Ninh VK, Miyamoto S, Aguirre AD, Fu Z, Heller Brown J, King KR. PMID: 33525909; PMCID: PMC7955351.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    9. Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling. PLoS Biol. 2020 09; 18(9):e3000866. Zhang JZ, Nguyen AH, Miyamoto S, Heller Brown J, McCulloch AD, Zhang J. PMID: 32881857; PMCID: PMC7494096.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Dissociation of mitochondrial HK-II elicits mitophagy and confers cardioprotection against ischemia. Cell Death Dis. 2019 09 30; 10(10):730. Tan VP, Smith JM, Tu M, Yu JD, Ding EY, Miyamoto S. PMID: 31570704; PMCID: PMC6768853.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    11. Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis. Front Immunol. 2019; 10:1743. de Oliveira PG, Farinon M, Sanchez-Lopez E, Miyamoto S, Guma M. PMID: 31428089; PMCID: PMC6688519.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    12. Autophagy and cardiac aging. Cell Death Differ. 2019 03; 26(4):653-664. Miyamoto S. PMID: 30692640; PMCID: PMC6460392.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    13. Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca2+/Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling. Circulation. 2018 11 27; 138(22):2530-2544. Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S, Brown JH. PMID: 30571348; PMCID: PMC6309790.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    14. Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis. Ann Rheum Dis. 2018 11; 77(11):1636-1643. Bustamante MF, Oliveira PG, Garcia-Carbonell R, Croft AP, Smith JM, Serrano RL, Sanchez-Lopez E, Liu X, Kisseleva T, Hay N, Buckley CD, Firestein GS, Murphy AN, Miyamoto S, Guma M. PMID: 30061164; PMCID: PMC6328432.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    15. RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes. Cell Signal. 2018 Oct; 50:48-57. Brand CS, Tan VP, Brown JH, Miyamoto S. PMID: 29953931; PMCID: PMC6361616.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    16. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. PMID: 29887596; PMCID: PMC6195840.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    17. CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α. J Mol Cell Cardiol. 2017 02; 103:48-55. Gray CB, Suetomi T, Xiang S, Mishra S, Blackwood EA, Glembotski CC, Miyamoto S, Westenbrink BD, Brown JH. PMID: 28077321; PMCID: PMC5564300.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    18. Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. J Mol Cell Cardiol. 2017 02; 103:1-10. Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell NH, Brown JH, Miyamoto S. PMID: 28017639; PMCID: PMC5410967.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    19. Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload. Circulation. 2016 Mar 29; 133(13):1225-7. Miyamoto S, Brown JH. PMID: 26915632; PMCID: PMC4811683.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    20. Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals. J Mol Cell Cardiol. 2016 06; 95:31-41. Tan VP, Miyamoto S. PMID: 26773603; PMCID: PMC4909545.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    21. Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation. Mol Cell Biol. 2016 Jan 01; 36(1):39-49. Yu OM, Miyamoto S, Brown JH. PMID: 26459764; PMCID: PMC4702594.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    22. Cellular redox status determines sensitivity to BNIP3-mediated cell death in cardiac myocytes. Am J Physiol Cell Physiol. 2015 Jun 15; 308(12):C983-92. Lee Y, Kubli DA, Hanna RA, Cortez MQ, Lee HY, Miyamoto S, Gustafsson ÅB. PMID: 25810259; PMCID: PMC4469750.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39. Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. PMID: 25605649; PMCID: PMC4344921.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    24. HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection. Autophagy. 2015; 11(6):963-4. Tan VP, Miyamoto S. PMID: 26075878; PMCID: PMC4502787.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    25. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. PMID: 25236710; PMCID: PMC4301603.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    26. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. J Mol Cell Cardiol. 2014 Oct; 75:152-61. Zhao X, Ding EY, Yu OM, Xiang SY, Tan-Sah VP, Yung BS, Hedgpeth J, Neubig RR, Lau LF, Brown JH, Miyamoto S. PMID: 25106095; PMCID: PMC4157956.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    27. Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition. Mol Cell. 2014 Feb 20; 53(4):521-33. Roberts DJ, Tan-Sah VP, Ding EY, Smith JM, Miyamoto S. PMID: 24462113; PMCID: PMC3943874.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    28. PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. Sci Signal. 2013 Dec 17; 6(306):ra108. Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Heller Brown J. PMID: 24345679; PMCID: PMC4035240.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    29. Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes. J Biol Chem. 2013 Aug 16; 288(33):23798-806. Roberts DJ, Tan-Sah VP, Smith JM, Miyamoto S. PMID: 23836898; PMCID: PMC3745326.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    30. Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure. Genes Dev. 2013 Jun 15; 27(12):1365-77. Thomas RL, Roberts DJ, Kubli DA, Lee Y, Quinsay MN, Owens JB, Fischer KM, Sussman MA, Miyamoto S, Gustafsson ÅB. PMID: 23788623; PMCID: PMC3701192.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    31. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res. 2011 Dec 09; 109(12):1354-62. Mishra S, Gray CB, Miyamoto S, Bers DM, Brown JH. PMID: 21998325; PMCID: PMC3241507.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    32. RhoA protects the mouse heart against ischemia/reperfusion injury. J Clin Invest. 2011 Aug; 121(8):3269-76. Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, Brown JH. PMID: 21747165; PMCID: PMC3148727.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    33. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 2010 Aug; 120(8):2805-16. Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G. PMID: 20644257; PMCID: PMC2912201.
      View in: PubMed   Mentions: 191     Fields:    Translation:AnimalsCells
    34. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res. 2010 Aug 20; 107(4):476-84. Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PMID: 20576936; PMCID: PMC2957297.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    35. Revisited and revised: is RhoA always a villain in cardiac pathophysiology? J Cardiovasc Transl Res. 2010 Aug; 3(4):330-43. Miyamoto S, Del Re DP, Xiang SY, Zhao X, Florholmen G, Brown JH. PMID: 20559774; PMCID: PMC3005405.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    36. Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J Bioenerg Biomembr. 2009 Apr; 41(2):169-80. Miyamoto S, Murphy AN, Brown JH. PMID: 19377835; PMCID: PMC2732429.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    37. Nuclear and mitochondrial signalling Akts in cardiomyocytes. Cardiovasc Res. 2009 May 01; 82(2):272-85. Miyamoto S, Rubio M, Sussman MA. PMID: 19279164; PMCID: PMC2675933.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    38. Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J Biol Chem. 2008 Dec 19; 283(51):35622-9. Del Re DP, Miyamoto S, Brown JH. PMID: 18854312; PMCID: PMC2602897.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    39. Group B streptococcal beta-hemolysin/cytolysin directly impairs cardiomyocyte viability and function. PLoS One. 2008 Jun 18; 3(6):e2446. Hensler ME, Miyamoto S, Nizet V. PMID: 18560574; PMCID: PMC2409074.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    40. S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. J Biol Chem. 2008 May 02; 283(18):11954-63. Means CK, Miyamoto S, Chun J, Brown JH. PMID: 18296752; PMCID: PMC2335351.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    41. RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. J Biol Chem. 2007 Mar 16; 282(11):8069-78. Del Re DP, Miyamoto S, Brown JH. PMID: 17234627.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    42. Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy. J Mol Cell Cardiol. 2006 May; 40(5):597-604. Howes AL, Miyamoto S, Adams JW, Woodcock EA, Brown JH. PMID: 16466740.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    43. Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. J Biol Chem. 2005 Nov 18; 280(46):38505-12. Miyamoto S, Howes AL, Adams JW, Dorn GW, Brown JH. PMID: 16061478.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    44. Cardiomyocyte calcium and calcium/calmodulin-dependent protein kinase II: friends or foes? Recent Prog Horm Res. 2004; 59:141-68. Zhang T, Miyamoto S, Brown JH. PMID: 14749501.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    45. Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. J Biol Chem. 2003 Oct 10; 278(41):40343-51. Howes AL, Arthur JF, Zhang T, Miyamoto S, Adams JW, Dorn GW, Woodcock EA, Brown JH. PMID: 12900409.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    46. Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation. J Biol Chem. 2003 Aug 15; 278(33):31111-7. Kawamura S, Miyamoto S, Brown JH. PMID: 12777392.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    47. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003 May 02; 92(8):912-9. Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J, Bers DM, Brown JH. PMID: 12676814.
      View in: PubMed   Mentions: 258     Fields:    Translation:AnimalsCells
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