 Naveen Gupta
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| Title(s) | Associate Clinical Professor, Medicine |
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| School | Health Sciences |
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| vCard | Download vCard |
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 Biography | University of California, San Francisco | Fellowship | 2006 | Pulmonary/Critical Care | | University of Michigan | Internship/Residency | 2003 | Internal Medicine | | University of Michigan | MD | 2000 | School of Medicine | | Stanford University | B.Sc. | 1996 | Biological Sciences |
| University of California, San Francisco | 2008
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| 2010 | Parker B Francis Fellowship in Pulmonary Research | | University of California, San Francisco | 2006
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| 2008 | California Institute of Regenerative Medicine Training Award |
Overview My research is focused primarily on understanding the therapeutic and mechanistic effects of bone marrow derived mesenchymal stem cells (MSCs) in experimental models of sepsis and lung injury. MSCs have been demonstrated to exert a variety of beneficial properties in infection related lung damage. Specifically, I am investigating the interplay between toll like receptors and protease activated receptors (PARs) on MSC survival and therapeutic activity.
Separately, I am interested in the potential therapeutic effects of PAR1 antagonism in experimental pneumonia and sepsis in vivo, and in particular the role of PAR1 on innate immune cells in the pathogenesis of infection related lung injury.
Research Bibliographic
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Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin JH, Nizet V, Corriden R. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. J Antimicrob Chemother. 2018 Jun 01; 73(6):1586-1594. PMID: 29514266.
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Gupta N, Nizet V. Stabilization of Hypoxia-Inducible Factor-1 Alpha Augments the Therapeutic Capacity of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Pneumonia. Front Med (Lausanne). 2018; 5:131. PMID: 29780805.
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Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH. The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia. Stem Cells. 2018 May; 36(5):796-806. PMID: 29396891.
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Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernández JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin JH. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood. 2018 Mar 15; 131(11):1163-1171. PMID: 29343482.
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Valderrama JA, Riestra AM, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V. Group A streptococcal M protein activates the NLRP3 inflammasome. Nat Microbiol. 2017 Oct; 2(10):1425-1434. PMID: 28784982.
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Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee JW, Gupta N, Petrini M, Matthay MA. Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes. Am J Physiol Lung Cell Mol Physiol. 2012 May 15; 302(10):L1003-13. PMID: 22427530; PMCID: PMC3362255.
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Gupta N, Krasnodembskaya A, Kapetanaki M, Mouded M, Tan X, Serikov V, Matthay MA. Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia. Thorax. 2012 Jun; 67(6):533-9. PMID: 22250097; PMCID: PMC3358432.
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Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA. Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells. 2010 Dec; 28(12):2229-38. PMID: 20945332; PMCID: PMC3293245.
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Lee JS, Su X, Rackley C, Matthay MA, Gupta N. Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Anat Rec (Hoboken). 2011 Jan; 294(1):165-72. PMID: 21157927; PMCID: PMC3072226.
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Lee JW, Gupta N, Serikov V, Matthay MA. Potential application of mesenchymal stem cells in acute lung injury. Expert Opin Biol Ther. 2009 Oct; 9(10):1259-70. PMID: 19691441; PMCID: PMC2852252.
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Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16357-62. PMID: 19721001.
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Su X, Looney MR, Gupta N, Matthay MA. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L1-5. PMID: 19411309; PMCID: PMC2711813.
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Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay MA. Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism. Tissue Eng. 2007 Oct; 13(10):2441-50. PMID: 17630877.
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Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay MA. Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. Anat Rec (Hoboken). 2007 Sep; 290(9):1033-45. PMID: 17661377.
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Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol. 2007 Aug 01; 179(3):1855-63. PMID: 17641052.
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Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):186-92. PMID: 17431097; PMCID: PMC1976545.
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Gupta N, Matthay MA. Sepsis and stretch: synergistic effects on alveolar epithelial cell death? Crit Care Med. 2006 Jun; 34(6):1846-7. PMID: 16714999.
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