Naveen Gupta
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Title(s) | Associate Clinical Professor, Medicine |
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School | Vc-health Sciences-schools |
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Address | 9500 Gilman Drive # La Jolla CA 92093
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vCard | Download vCard |
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Biography University of California, San Francisco | Fellowship | 2006 | Pulmonary/Critical Care | University of Michigan | Internship/Residency | 2003 | Internal Medicine | University of Michigan | MD | 2000 | School of Medicine | Stanford University | B.Sc. | 1996 | Biological Sciences |
University of California, San Francisco | 2008
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| 2010 | Parker B Francis Fellowship in Pulmonary Research | University of California, San Francisco | 2006
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| 2008 | California Institute of Regenerative Medicine Training Award |
Overview My research is focused primarily on understanding the therapeutic and mechanistic effects of bone marrow derived mesenchymal stem cells (MSCs) in experimental models of sepsis and lung injury. MSCs have been demonstrated to exert a variety of beneficial properties in infection related lung damage. Specifically, I am investigating the interplay between toll like receptors and protease activated receptors (PARs) on MSC survival and therapeutic activity.
Separately, I am interested in the potential therapeutic effects of PAR1 antagonism in experimental pneumonia and sepsis in vivo, and in particular the role of PAR1 on innate immune cells in the pathogenesis of infection related lung injury.
Research Bibliographic
Altmetrics Details
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(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. J Antimicrob Chemother. 2018 06 01; 73(6):1586-1594.
PMID: 29514266.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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Stabilization of Hypoxia-Inducible Factor-1 Alpha Augments the Therapeutic Capacity of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Pneumonia. Front Med (Lausanne). 2018; 5:131.
PMID: 29780805.
View in: PubMed Mentions:
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The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia. Stem Cells. 2018 05; 36(5):796-806.
PMID: 29396891.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood. 2018 03 15; 131(11):1163-1171.
PMID: 29343482.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Group A streptococcal M protein activates the NLRP3 inflammasome. Nat Microbiol. 2017 Oct; 2(10):1425-1434.
Valderrama JA, Riestra AM, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V. PMID: 28784982.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimalsCells
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Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes. . 2012 May 15; 302(10):L1003-13.
PMID: 22427530.
View in: PubMed Mentions:
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Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia. Thorax. 2012 Jun; 67(6):533-9.
PMID: 22250097.
View in: PubMed Mentions: 102 Fields: Translation: AnimalsCells
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Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells. 2010 Dec; 28(12):2229-38.
Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA. PMID: 20945332.
View in: PubMed Mentions: 215 Fields: Translation: HumansAnimalsCells
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Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Anat Rec (Hoboken). 2011 Jan; 294(1):165-72.
Lee JS, Su X, Rackley C, Matthay MA, Gupta N. PMID: 21157927.
View in: PubMed Mentions: 4 Fields: Translation: Animals
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Potential application of mesenchymal stem cells in acute lung injury. Expert Opin Biol Ther. 2009 Oct; 9(10):1259-70.
Lee JW, Gupta N, Serikov V, Matthay MA. PMID: 19691441.
View in: PubMed Mentions: 48 Fields: Translation: HumansAnimalsCells
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Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16357-62.
Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. PMID: 19721001.
View in: PubMed Mentions: 230 Fields: Translation: HumansCells
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Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. . 2009 Jul; 297(1):L1-5.
Su X, Looney MR, Gupta N, Matthay MA. PMID: 19411309.
View in: PubMed Mentions:
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Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism. Tissue Eng. 2007 Oct; 13(10):2441-50.
Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay MA. PMID: 17630877.
View in: PubMed Mentions: 15 Fields: Translation: AnimalsCells
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Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. Anat Rec (Hoboken). 2007 Sep; 290(9):1033-45.
Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay MA. PMID: 17661377.
View in: PubMed Mentions: 18 Fields: Translation: AnimalsCells
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Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol. 2007 Aug 01; 179(3):1855-63.
Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. PMID: 17641052.
View in: PubMed Mentions: 343 Fields: Translation: AnimalsCells
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Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):186-92.
Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. PMID: 17431097.
View in: PubMed Mentions: 70 Fields: Translation: HumansAnimalsCells
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Sepsis and stretch: synergistic effects on alveolar epithelial cell death? Crit Care Med. 2006 Jun; 34(6):1846-7.
Gupta N, Matthay MA. PMID: 16714999.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Year | Publications |
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2006 | 1 | 2007 | 4 | 2009 | 3 | 2010 | 2 | 2012 | 2 | 2017 | 1 | 2018 | 4 |
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