Naveen Gupta

Title(s)Clinical Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse education and training
    University of California, San FranciscoFellowship2006Pulmonary/Critical Care
    University of MichiganInternship/Residency2003Internal Medicine
    University of MichiganMD2000School of Medicine
    Stanford UniversityB.Sc.1996Biological Sciences
    Collapse awards and honors
    University of California, San Francisco2008  - 2010Parker B Francis Fellowship in Pulmonary Research
    University of California, San Francisco2006  - 2008California Institute of Regenerative Medicine Training Award

    Collapse Overview 
    Collapse overview
    My research is focused primarily on understanding the therapeutic and mechanistic effects of bone marrow derived mesenchymal stem cells (MSCs) in experimental models of sepsis and lung injury. MSCs have been demonstrated to exert a variety of beneficial properties in infection related lung damage. Specifically, I am investigating the interplay between toll like receptors and protease activated receptors (PARs) on MSC survival and therapeutic activity.

    Separately, I am interested in the potential therapeutic effects of PAR1 antagonism in experimental pneumonia and sepsis in vivo, and in particular the role of PAR1 on innate immune cells in the pathogenesis of infection related lung injury.

    Collapse Research 
    Collapse research activities and funding
    Cell Based Therapy for Experimental Acute Lung Injury
    NIH K08HL092059Jan 1, 2009 - Jul 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Protease Activated Receptors: A Pathway to Boosting Mesenchymal Stromal Cell Therapeutic Efficacy in Acute Respiratory Distress Syndrome? Int J Mol Sci. 2022 Jan 24; 23(3). Gupta N. PMID: 35163205; PMCID: PMC8836081.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. J Antimicrob Chemother. 2018 06 01; 73(6):1586-1594. Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin JH, Nizet V, Corriden R. PMID: 29514266; PMCID: PMC5961356.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    3. Stabilization of Hypoxia-Inducible Factor-1 Alpha Augments the Therapeutic Capacity of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Pneumonia. Front Med (Lausanne). 2018; 5:131. Gupta N, Nizet V. PMID: 29780805; PMCID: PMC5945808.
      View in: PubMed   Mentions: 8  
    4. The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia. Stem Cells. 2018 05; 36(5):796-806. Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH. PMID: 29396891; PMCID: PMC5918231.
      View in: PubMed   Mentions: 22     Fields:    
    5. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood. 2018 03 15; 131(11):1163-1171. Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernández JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin JH. PMID: 29343482; PMCID: PMC5855020.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    6. Group A streptococcal M protein activates the NLRP3 inflammasome. Nat Microbiol. 2017 Oct; 2(10):1425-1434. Valderrama JA, Riestra AM, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V. PMID: 28784982; PMCID: PMC5750061.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    7. Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes. Am J Physiol Lung Cell Mol Physiol. 2012 May 15; 302(10):L1003-13. Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee JW, Gupta N, Petrini M, Matthay MA. PMID: 22427530; PMCID: PMC3362255.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimalsCells
    8. Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia. Thorax. 2012 Jun; 67(6):533-9. Gupta N, Krasnodembskaya A, Kapetanaki M, Mouded M, Tan X, Serikov V, Matthay MA. PMID: 22250097; PMCID: PMC3358432.
      View in: PubMed   Mentions: 171     Fields:    
    9. Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells. 2010 Dec; 28(12):2229-38. Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA. PMID: 20945332; PMCID: PMC3293245.
      View in: PubMed   Mentions: 365     Fields:    
    10. Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Anat Rec (Hoboken). 2011 Jan; 294(1):165-72. Lee JS, Su X, Rackley C, Matthay MA, Gupta N. PMID: 21157927; PMCID: PMC3072226.
      View in: PubMed   Mentions: 6     Fields:    
    11. Potential application of mesenchymal stem cells in acute lung injury. Expert Opin Biol Ther. 2009 Oct; 9(10):1259-70. Lee JW, Gupta N, Serikov V, Matthay MA. PMID: 19691441; PMCID: PMC2852252.
      View in: PubMed   Mentions: 77     Fields:    
    12. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16357-62. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. PMID: 19721001; PMCID: PMC2735560.
      View in: PubMed   Mentions: 305     Fields:    Translation:HumansCells
    13. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L1-5. Su X, Looney MR, Gupta N, Matthay MA. PMID: 19411309; PMCID: PMC2711813.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    14. Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism. Tissue Eng. 2007 Oct; 13(10):2441-50. Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay MA. PMID: 17630877.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    15. Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. Anat Rec (Hoboken). 2007 Sep; 290(9):1033-45. Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay MA. PMID: 17661377.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    16. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol. 2007 Aug 01; 179(3):1855-63. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. PMID: 17641052.
      View in: PubMed   Mentions: 421     Fields:    Translation:AnimalsCells
    17. Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):186-92. Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. PMID: 17431097; PMCID: PMC1976545.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    18. Sepsis and stretch: synergistic effects on alveolar epithelial cell death? Crit Care Med. 2006 Jun; 34(6):1846-7. Gupta N, Matthay MA. PMID: 16714999.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
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