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    Elina Zuniga

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0322
    CA La Jolla 92093
    Phone858-534-5660
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      Collapse Research 
      Collapse Research Activities and Funding
      Positive Immune-regulators During Chronic Viral Infections
      NIH/NIAID R01AI113923Feb 1, 2015 - Jan 31, 2020
      Role: Principal Investigator
      Characterizing Inflammation And Downstream Effects During Chronic Viral Infection
      NIH/NIAID R56AI097662Aug 27, 2012 - Jul 31, 2014
      Role: Principal Investigator
      GP130 Signaling During Chronic Virus Infection
      NIH/NIAID R21AI101561Jul 1, 2012 - Jun 30, 2014
      Role: Principal Investigator
      Arenavirus Subversion of Dendritic Cells
      NIH/NIAID R21AI102247Jul 1, 2012 - Jun 30, 2014
      Role: Principal Investigator
      Inhibitory Pathways Underlying Viral Persistence In Vivo
      NIH/NIAID R01AI081923Jul 1, 2009 - Jan 31, 2020
      Role: Principal Investigator
      Virus interference with Toll like Receptor Response on Dendritic Cells
      NIH/NIAID R21AI072752Jun 5, 2009 - May 31, 2011
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga E, Goldrath AW, Chang JT, Yeo GW. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing. Nat Immunol. 2017 Feb 20. PMID: 28218746.
        View in: PubMed
      2. Lewis GM, Wehrens EJ, Labarta-Bajo L, Streeck H, Zuniga E. TGF-ß receptor maintains CD4 T helper cell identity during chronic viral infections. J Clin Invest. 2016 Oct 3; 126(10):3799-3813. PMID: 27599295.
        View in: PubMed
      3. El Ghazal R, Yin X, Johns SC, Swanson L, Macal M, Ghosh P, Zuniga E, Fuster MM. Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth. Neoplasia. 2016 May; 18(5):294-306. PMID: 27237321.
        View in: PubMed
      4. Taylor A, Harker JA, Chanthong K, Stevenson PG, Zuniga E, Rudd CE. Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses. Immunity. 2016 Feb 16; 44(2):274-86. PMID: 26885856.
        View in: PubMed
      5. Macal M, Tam MA, Hesser C, Di Domizio J, Leger P, Gilliet M, Zuniga E. CD28 Deficiency Enhances Type I IFN Production by Murine Plasmacytoid Dendritic Cells. J Immunol. 2016 Feb 15; 196(4):1900-9. PMID: 26773151.
        View in: PubMed
      6. Zuniga E, Macal M, Lewis GM, Harker JA. Innate and Adaptive Immune Regulation During Chronic Viral Infections. Annu Rev Virol. 2015 Nov; 2(1):573-97. PMID: 26958929.
        View in: PubMed
      7. Harker JA, Wong KA, Dolgoter A, Zuniga E. Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity. J Immunol. 2015 Aug 1; 195(3):1071-81. PMID: 26085685.
        View in: PubMed
      8. Movita D, van de Garde MD, Biesta P, Kreefft K, Haagmans B, Zuniga E, Herschke F, De Jonghe S, Janssen HL, Gama L, Boonstra A, Vanwolleghem T. Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct. J Virol. 2015 May; 89(9):4809-17. PMID: 25673700; PMCID: PMC4403491.
        View in: PubMed, PubMed Central
      9. Harker JA, Dolgoter A, Zuniga E. Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4? T cell responses and viral control during chronic infection. Immunity. 2013 Sep 19; 39(3):548-59. PMID: 23993651.
        View in: PubMed
      10. Shih VF, Davis-Turak J, Macal M, Huang JQ, Ponomarenko J, Kearns JD, Yu T, Fagerlund R, Asagiri M, Zuniga E, Hoffmann A. Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-?B pathways. Nat Immunol. 2012 Dec; 13(12):1162-70. PMID: 23086447.
        View in: PubMed
      11. Zuniga E, Harker JA. T-cell exhaustion due to persistent antigen: quantity not quality? Eur J Immunol. 2012 Sep; 42(9):2285-9. PMID: 22949327.
        View in: PubMed
      12. Walsh KB, Teijaro JR, Zuniga E, Welch MJ, Fremgen DM, Blackburn SD, von Tiehl KF, Wherry EJ, Flavell RA, Oldstone MB. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host Microbe. 2012 Jun 14; 11(6):643-53. PMID: 22704624.
        View in: PubMed
      13. Harker JA, Lewis GM, Mack L, Zuniga E. Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science. 2011 Nov 11; 334(6057):825-9. PMID: 21960530.
        View in: PubMed
      14. Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga E. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity. 2009 Jul 17; 31(1):145-57. PMID: 19604493.
        View in: PubMed
      15. Liou LY, Blasius AL, Welch MJ, Colonna M, Oldstone MB, Zuniga E. In vivo conversion of BM plasmacytoid DC into CD11b+ conventional DC during virus infection. Eur J Immunol. 2008 Dec; 38(12):3388-94. PMID: 18979509.
        View in: PubMed
      16. Zuniga E, Liou LY, Mack L, Mendoza M, Oldstone MB. Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections. Cell Host Microbe. 2008 Oct 16; 4(4):374-86. PMID: 18854241.
        View in: PubMed
      17. Rothlin CV, Ghosh S, Zuniga E, Oldstone MB, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007 Dec 14; 131(6):1124-36. PMID: 18083102.
        View in: PubMed
      18. Acosta Rodriguez EV, Zuniga E, Montes CL, Merino MC, Bermejo DA, Amezcua Vesely MC, Motran CC, Gruppi A. Trypanosoma cruzi infection beats the B-cell compartment favouring parasite establishment: can we strike first? Scand J Immunol. 2007 Aug-Sep; 66(2-3):137-42. PMID: 17635791.
        View in: PubMed
      19. Zuniga E, Hahm B, Oldstone MB. Type I interferon during viral infections: multiple triggers for a multifunctional mediator. Curr Top Microbiol Immunol. 2007; 316:337-57. PMID: 17969455.
        View in: PubMed
      20. Trifilo MJ, Hahm B, Zuniga E, Edelmann KH, Oldstone MB. Dendritic cell inhibition: memoirs from immunosuppressive viruses. J Infect Dis. 2006 Sep 15; 194 Suppl 1:S3-10. PMID: 16921469.
        View in: PubMed
      21. Lauterbach H, Zuniga E, Truong P, Oldstone MB, McGavern DB. Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. J Exp Med. 2006 Aug 7; 203(8):1963-75. PMID: 16847068.
        View in: PubMed
      22. Montes CL, Acosta-Rodríguez EV, Mucci J, Zuniga E, Campetella O, Gruppi A. A Trypanosoma cruzi antigen signals CD11b+ cells to secrete cytokines that promote polyclonal B cell proliferation and differentiation into antibody-secreting cells. Eur J Immunol. 2006 Jun; 36(6):1474-85. PMID: 16688679.
        View in: PubMed
      23. Zuniga E, Acosta-Rodriguez E, Merino MC, Montes C, Gruppi A. Depletion of immature B cells during Trypanosoma cruzi infection: involvement of myeloid cells and the cyclooxygenase pathway. Eur J Immunol. 2005 Jun; 35(6):1849-58. PMID: 15864778.
        View in: PubMed
      24. Hahm B, Trifilo MJ, Zuniga E, Oldstone MB. Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Immunity. 2005 Feb; 22(2):247-57. PMID: 15723812.
        View in: PubMed
      25. Zuniga E, McGavern DB, Pruneda-Paz JL, Teng C, Oldstone MB. Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection. Nat Immunol. 2004 Dec; 5(12):1227-34. PMID: 15531885.
        View in: PubMed
      26. Acosta-Rodríguez EV, Montes CL, Motrán CC, Zuniga E, Liu FT, Rabinovich GA, Gruppi A. Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection. J Immunol. 2004 Jan 1; 172(1):493-502. PMID: 14688359.
        View in: PubMed
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