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Elina Zuniga

TitleResearcher
InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0322
La Jolla CA 92093
Phone858-534-5660
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    Collapse Research 
    Collapse Research Activities and Funding
    Positive Immune-regulators During Chronic Viral Infections
    NIH/NIAID R01AI113923Feb 1, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Characterizing Inflammation And Downstream Effects During Chronic Viral Infection
    NIH/NIAID R56AI097662Aug 27, 2012 - Jul 31, 2014
    Role: Principal Investigator
    GP130 Signaling During Chronic Virus Infection
    NIH/NIAID R21AI101561Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Arenavirus Subversion of Dendritic Cells
    NIH/NIAID R21AI102247Jul 1, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Inhibitory Pathways Underlying Viral Persistence In Vivo
    NIH/NIAID R01AI081923Jul 1, 2009 - Jan 31, 2020
    Role: Principal Investigator
    Virus interference with Toll like Receptor Response on Dendritic Cells
    NIH/NIAID R21AI072752Jun 5, 2009 - May 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Harker JA, Wong KA, Dallari S, Bao P, Dolgoter A, Jo Y, Wehrens EJ, Macal M, Zuniga E. IL-27R signalling mediates early viral containment and impacts innate and adaptive immunity after chronic lymphocytic choriomeningitis virus infection. J Virol. 2018 Mar 28. PMID: 29593047.
      View in: PubMed
    2. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga E, Goldrath AW, Chang JT, Yeo GW. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing. Nat Immunol. 2017 04; 18(4):422-432. PMID: 28218746.
      View in: PubMed
    3. Lewis GM, Wehrens EJ, Labarta-Bajo L, Streeck H, Zuniga E. TGF-ß receptor maintains CD4 T helper cell identity during chronic viral infections. J Clin Invest. 2016 Oct 03; 126(10):3799-3813. PMID: 27599295.
      View in: PubMed
    4. El Ghazal R, Yin X, Johns SC, Swanson L, Macal M, Ghosh P, Zuniga E, Fuster MM. Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth. Neoplasia. 2016 05; 18(5):294-306. PMID: 27237321; PMCID: PMC4887599.
      View in: PubMed, PubMed Central
    5. Taylor A, Harker JA, Chanthong K, Stevenson PG, Zuniga E, Rudd CE. Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses. Immunity. 2016 Feb 16; 44(2):274-86. PMID: 26885856; PMCID: PMC4760122.
      View in: PubMed, PubMed Central
    6. Macal M, Tam MA, Hesser C, Di Domizio J, Leger P, Gilliet M, Zuniga E. CD28 Deficiency Enhances Type I IFN Production by Murine Plasmacytoid Dendritic Cells. J Immunol. 2016 Feb 15; 196(4):1900-9. PMID: 26773151; PMCID: PMC4744517 [Available on 02/15/17].
      View in: PubMed, PubMed Central
    7. Zuniga E, Macal M, Lewis GM, Harker JA. Innate and Adaptive Immune Regulation During Chronic Viral Infections. Annu Rev Virol. 2015 Nov; 2(1):573-97. PMID: 26958929.
      View in: PubMed
    8. Harker JA, Wong KA, Dolgoter A, Zuniga E. Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity. J Immunol. 2015 Aug 01; 195(3):1071-81. PMID: 26085685.
      View in: PubMed
    9. Movita D, van de Garde MD, Biesta P, Kreefft K, Haagmans B, Zuniga E, Herschke F, De Jonghe S, Janssen HL, Gama L, Boonstra A, Vanwolleghem T. Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct. J Virol. 2015 May; 89(9):4809-17. PMID: 25673700; PMCID: PMC4403491.
      View in: PubMed, PubMed Central
    10. Harker JA, Dolgoter A, Zuniga E. Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4? T cell responses and viral control during chronic infection. Immunity. 2013 Sep 19; 39(3):548-59. PMID: 23993651; PMCID: PMC4701058.
      View in: PubMed, PubMed Central
    11. Shih VF, Davis-Turak J, Macal M, Huang JQ, Ponomarenko J, Kearns JD, Yu T, Fagerlund R, Asagiri M, Zuniga E, Hoffmann A. Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-?B pathways. Nat Immunol. 2012 Dec; 13(12):1162-70. PMID: 23086447; PMCID: PMC3634611.
      View in: PubMed, PubMed Central
    12. Zuniga E, Harker JA. T-cell exhaustion due to persistent antigen: quantity not quality? Eur J Immunol. 2012 Sep; 42(9):2285-9. PMID: 22949327; PMCID: PMC3684559.
      View in: PubMed, PubMed Central
    13. Walsh KB, Teijaro JR, Zuniga E, Welch MJ, Fremgen DM, Blackburn SD, von Tiehl KF, Wherry EJ, Flavell RA, Oldstone MB. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host Microbe. 2012 Jun 14; 11(6):643-53. PMID: 22704624; PMCID: PMC3377981.
      View in: PubMed, PubMed Central
    14. Harker JA, Lewis GM, Mack L, Zuniga E. Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science. 2011 Nov 11; 334(6057):825-9. PMID: 21960530; PMCID: PMC3388900.
      View in: PubMed, PubMed Central
    15. Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga E. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity. 2009 Jul 17; 31(1):145-57. PMID: 19604493; PMCID: PMC3039716.
      View in: PubMed, PubMed Central
    16. Liou LY, Blasius AL, Welch MJ, Colonna M, Oldstone MB, Zuniga E. In vivo conversion of BM plasmacytoid DC into CD11b+ conventional DC during virus infection. Eur J Immunol. 2008 Dec; 38(12):3388-94. PMID: 18979509; PMCID: PMC2897746.
      View in: PubMed, PubMed Central
    17. Zuniga E, Liou LY, Mack L, Mendoza M, Oldstone MB. Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections. Cell Host Microbe. 2008 Oct 16; 4(4):374-86. PMID: 18854241; PMCID: PMC2875928.
      View in: PubMed, PubMed Central
    18. Rothlin CV, Ghosh S, Zuniga E, Oldstone MB, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007 Dec 14; 131(6):1124-36. PMID: 18083102.
      View in: PubMed
    19. Trifilo MJ, Hahm B, Zuniga E, Edelmann KH, Oldstone MB. Dendritic cell inhibition: memoirs from immunosuppressive viruses. J Infect Dis. 2006 Sep 15; 194 Suppl 1:S3-10. PMID: 16921469.
      View in: PubMed
    20. Lauterbach H, Zuniga E, Truong P, Oldstone MB, McGavern DB. Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. J Exp Med. 2006 Aug 07; 203(8):1963-75. PMID: 16847068; PMCID: PMC2118382.
      View in: PubMed, PubMed Central
    21. Montes CL, Acosta-Rodríguez EV, Mucci J, Zuniga E, Campetella O, Gruppi A. A Trypanosoma cruzi antigen signals CD11b+ cells to secrete cytokines that promote polyclonal B cell proliferation and differentiation into antibody-secreting cells. Eur J Immunol. 2006 Jun; 36(6):1474-85. PMID: 16688679.
      View in: PubMed
    22. Zuniga E, Acosta-Rodriguez E, Merino MC, Montes C, Gruppi A. Depletion of immature B cells during Trypanosoma cruzi infection: involvement of myeloid cells and the cyclooxygenase pathway. Eur J Immunol. 2005 Jun; 35(6):1849-58. PMID: 15864778.
      View in: PubMed
    23. Hahm B, Trifilo MJ, Zuniga E, Oldstone MB. Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Immunity. 2005 Feb; 22(2):247-57. PMID: 15723812.
      View in: PubMed
    24. Zuniga E, McGavern DB, Pruneda-Paz JL, Teng C, Oldstone MB. Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection. Nat Immunol. 2004 Dec; 5(12):1227-34. PMID: 15531885.
      View in: PubMed
    25. Acosta-Rodríguez EV, Montes CL, Motrán CC, Zuniga E, Liu FT, Rabinovich GA, Gruppi A. Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection. J Immunol. 2004 Jan 01; 172(1):493-502. PMID: 14688359.
      View in: PubMed
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