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    Paul Grossfeld

    TitleClinical Professor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0984
    CA La Jolla 92093
    Phone858-822-1957
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      Collapse Research 
      Collapse Research Activities and Funding
      The Role of IgLONS in Cardiac Development and Disease
      NIH/NHLBI K08HL070640Apr 1, 2003 - Mar 31, 2008
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Herrick N, Davis C, Vargas L, Dietz H, Grossfeld P. Utility of Genetic Testing in Elite Volleyball Players with Aortic Root Dilation. Med Sci Sports Exerc. 2017 Jul; 49(7):1293-1296. PMID: 28240702.
        View in: PubMed
      2. van Vliet PP, Lin L, Boogerd CJ, Martin JF, Andelfinger G, Grossfeld P, Evans SM. Tissue specific requirements for WNT11 in developing outflow tract and dorsal mesenchymal protrusion. Dev Biol. 2017 Sep 01; 429(1):249-259. PMID: 28669819.
        View in: PubMed
      3. Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray SA, Porter GA, Tsang M, Martin LJ, Benson DW, Aronow BJ, Lo CW. The complex genetics of hypoplastic left heart syndrome. Nat Genet. 2017 Jul; 49(7):1152-1159. PMID: 28530678.
        View in: PubMed
      4. Grossfeld P. Brain hemorrhages in Jacobsen syndrome: A retrospective review of six cases and clinical recommendations. Am J Med Genet A. 2017 Mar; 173(3):667-670. PMID: 28211970.
        View in: PubMed
      5. Nakamura T, Arima-Yoshida F, Sakaue F, Nasu-Nishimura Y, Takeda Y, Matsuura K, Akshoomoff N, Mattson SN, Grossfeld P, Manabe T, Akiyama T. PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking. Nat Commun. 2016 Mar 16; 7:10861. PMID: 26979507; PMCID: PMC4799364.
      6. Glidewell SC, Miyamoto SD, Grossfeld P, Clouthier DE, Coldren CD, Stearman RS, Geraci MW. Transcriptional Impact of Rare and Private Copy Number Variants in Hypoplastic Left Heart Syndrome. Clin Transl Sci. 2015 Dec; 8(6):682-9. PMID: 26534787; PMCID: PMC4703543 [Available on 12/01/16].
      7. Davis CK, Dyar DA, Vargas LA, Grossfeld P. Cardiovascular and Musculoskeletal Assessment of Elite US Volleyball Players. Clin J Sport Med. 2015 Nov; 25(6):546-50. PMID: 25756701.
        View in: PubMed
      8. Favier R, Akshoomoff N, Mattson S, Grossfeld P. Jacobsen syndrome: Advances in our knowledge of phenotype and genotype. Am J Med Genet C Semin Med Genet. 2015 Sep; 169(3):239-50. PMID: 26285164.
        View in: PubMed
      9. Lacro RV, Dietz HC, Sleeper LA, Yetman AT, Bradley TJ, Colan SD, Pearson GD, Selamet Tierney ES, Levine JC, Atz AM, Benson DW, Braverman AC, Chen S, De Backer J, Gelb BD, Grossfeld P, Klein GL, Lai WW, Liou A, Loeys BL, Markham LW, Olson AK, Paridon SM, Pemberton VL, Pierpont ME, Pyeritz RE, Radojewski E, Roman MJ, Sharkey AM, Stylianou MP, Wechsler SB, Young LT, Mahony L. Atenolol versus losartan in children and young adults with Marfan's syndrome. N Engl J Med. 2014 Nov 27; 371(22):2061-71. PMID: 25405392; PMCID: PMC4386623.
      10. Akshoomoff N, Mattson SN, Grossfeld P. Evidence for autism spectrum disorder in Jacobsen syndrome: identification of a candidate gene in distal 11q. Genet Med. 2015 Feb; 17(2):143-8. PMID: 25058499.
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      11. Ye M, Parente F, Li X, Perryman MB, Zelante L, Wynshaw-Boris A, Chen J, Grossfeld P. Gene-targeted deletion of OPCML and Neurotrimin in mice does not yield congenital heart defects. Am J Med Genet A. 2014 Apr; 164A(4):966-74. PMID: 24616287.
        View in: PubMed
      12. Esposito G, Butler TL, Blue GM, Cole AD, Sholler GF, Kirk EP, Grossfeld P, Perryman BM, Harvey RP, Winlaw DS. Somatic mutations in NKX2–5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart. Am J Med Genet A. 2011 Oct; 155A(10):2416-21. PMID: 22043484.
        View in: PubMed
      13. Lin AE, Alexander ME, Colan SD, Kerr B, Rauen KA, Noonan J, Baffa J, Hopkins E, Sol-Church K, Limongelli G, Digilio MC, Marino B, Innes AM, Aoki Y, Silberbach M, Delrue MA, White SM, Hamilton RM, O'Connor W, Grossfeld P, Smoot LB, Padera RF, Gripp KW. Clinical, pathological, and molecular analyses of cardiovascular abnormalities in Costello syndrome: a Ras/MAPK pathway syndrome. Am J Med Genet A. 2011 Mar; 155A(3):486-507. PMID: 21344638.
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      14. Fisch GS, Grossfeld P, Falk R, Battaglia A, Youngblom J, Simensen R. Cognitive-behavioral features of Wolf-Hirschhorn syndrome and other subtelomeric microdeletions. Am J Med Genet C Semin Med Genet. 2010 Nov 15; 154C(4):417-26. PMID: 20981770.
        View in: PubMed
      15. Grossfeld P, Greenberg M, Saw S, Cheng G, Stanzi A, Mathewson J, Pises N, Lyda L, Vuthy S, Elias W, Moriarty S, Levy S, Walter D, Panzarella P, Grossfeld S, Kriett J, Madani M. Successful surgical closure of an arterial duct in 18 children in a third world country. Cardiol Young. 2010 Aug; 20(4):367-72. PMID: 20482943.
        View in: PubMed
      16. Bratincsák A, El-Said HG, Bradley JS, Shayan K, Grossfeld P, Cannavino CR. Fulminant myocarditis associated with pandemic H1N1 influenza A virus in children. J Am Coll Cardiol. 2010 Mar 02; 55(9):928-9. PMID: 20153131.
        View in: PubMed
      17. Ye M, Coldren C, Liang X, Mattina T, Goldmuntz E, Benson DW, Ivy D, Perryman MB, Garrett-Sinha LA, Grossfeld P. Deletion of ETS-1, a gene in the Jacobsen syndrome critical region, causes ventricular septal defects and abnormal ventricular morphology in mice. Hum Mol Genet. 2010 Feb 15; 19(4):648-56. PMID: 19942620; PMCID: PMC2807373.
      18. Krous HF, Ferandos C, Masoumi H, Arnold J, Haas EA, Stanley C, Grossfeld P. Myocardial inflammation, cellular death, and viral detection in sudden infant death caused by SIDS, suffocation, or myocarditis. Pediatr Res. 2009 Jul; 66(1):17-21. PMID: 19287341.
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      19. Ye M, Hamzeh R, Geddis A, Varki N, Perryman MB, Grossfeld P. Deletion of JAM-C, a candidate gene for heart defects in Jacobsen syndrome, results in a normal cardiac phenotype in mice. Am J Med Genet A. 2009 Jul; 149A(7):1438-43. PMID: 19533782.
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      20. Grossfeld P, Ye M, Harvey R. Hypoplastic left heart syndrome: new genetic insights. J Am Coll Cardiol. 2009 Mar 24; 53(12):1072-4. PMID: 19298922.
        View in: PubMed
      21. Mattina T, Perrotta CS, Grossfeld P. Jacobsen syndrome. Orphanet J Rare Dis. 2009 Mar 07; 4:9. PMID: 19267933; PMCID: PMC2670819.
      22. Coldren CD, Lai Z, Shragg P, Rossi E, Glidewell SC, Zuffardi O, Mattina T, Ivy DD, Curfs LM, Mattson SN, Riley EP, Treier M, Grossfeld P. Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome). Neurogenetics. 2009 Apr; 10(2):89-95. PMID: 18855024; PMCID: PMC3050515.
      23. Maas AP, Grossfeld P, Didden R, Korzilius H, Braam WJ, Smits MG, Curfs LM. Sleep problems in individuals with 11q terminal deletion disorder (Jacobsen syndrome). Genet Couns. 2008; 19(2):225-35. PMID: 18618998.
        View in: PubMed
      24. Grossfeld P. Hypoplastic left heart syndrome: it is all in the genes. J Am Coll Cardiol. 2007 Oct 16; 50(16):1596-7. PMID: 17936160.
        View in: PubMed
      25. Podraza J, Fleenor J, Grossfeld P. An 11q terminal deletion and tetralogy of Fallot. Am J Med Genet A. 2007 May 15; 143A(10):1126-8. PMID: 17431904.
        View in: PubMed
      26. Grossfeld P. Hypoplastic left heart syndrome: new insights. Circ Res. 2007 May 11; 100(9):1246-8. PMID: 17495231.
        View in: PubMed
      27. Bose AK, Mathewson JW, Anderson BE, Andrews AM, Martin Gerdes A, Benjamin Perryman M, Grossfeld P. Initial experience with high frequency ultrasound for the newborn C57BL mouse. Echocardiography. 2007 Apr; 24(4):412-9. PMID: 17381652.
        View in: PubMed
      28. Wenger SL, Grossfeld P, Siu BL, Coad JE, Keller FG, Hummel M. Molecular characterization of an 11q interstitial deletion in a patient with the clinical features of Jacobsen syndrome. Am J Med Genet A. 2006 Apr 01; 140(7):704-8. PMID: 16502431.
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      29. Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld P, Srivastava D. Mutations in NOTCH1 cause aortic valve disease. Nature. 2005 Sep 08; 437(7056):270-4. PMID: 16025100.
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      30. Wessels MW, Berger RM, Frohn-Mulder IM, Roos-Hesselink JW, Hoogeboom JJ, Mancini GS, Bartelings MM, Krijger Rd, Wladimiroff JW, Niermeijer MF, Grossfeld P, Willems PJ. Autosomal dominant inheritance of left ventricular outflow tract obstruction. Am J Med Genet A. 2005 Apr 15; 134A(2):171-9. PMID: 15712195.
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      31. Grossfeld P, Mattina T, Lai Z, Favier R, Jones KL, Cotter F, Jones C. The 11q terminal deletion disorder: a prospective study of 110 cases. Am J Med Genet A. 2004 Aug 15; 129A(1):51-61. PMID: 15266616.
        View in: PubMed
      32. Haghi M, Dewan A, Jones KL, Reitz R, Jones C, Grossfeld P. Endocrine abnormalities in patients with Jacobsen (11q-) syndrome. Am J Med Genet A. 2004 Aug 15; 129A(1):62-3. PMID: 15266617.
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      33. Lee WB, O'Halloran HS, Grossfeld P, Scher C, Jockin YM, Jones C. Ocular findings in Jacobsen syndrome. J AAPOS. 2004 Apr; 8(2):141-5. PMID: 15088047.
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      34. Favier R, Jondeau K, Boutard P, Grossfeld P, Reinert P, Jones C, Bertoni F, Cramer EM. Paris-Trousseau syndrome : clinical, hematological, molecular data of ten new cases. Thromb Haemost. 2003 Nov; 90(5):893-7. PMID: 14597985.
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      35. Elliott DA, Kirk EP, Yeoh T, Chandar S, McKenzie F, Taylor P, Grossfeld P, Fatkin D, Jones O, Hayes P, Feneley M, Harvey RP. Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome. J Am Coll Cardiol. 2003 Jun 04; 41(11):2072-6. PMID: 12798584.
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      36. Rothman A, Levy DJ, Sklansky MS, Grossfeld P, Auger WR, Ajami GH, Behling CA. Balloon angioplasty and stenting of multiple intralobar pulmonary arterial stenoses in adult patients. Catheter Cardiovasc Interv. 2003 Feb; 58(2):252-60. PMID: 12552552.
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      37. Grossfeld P. The genetics of congenital heart disease. J Nucl Cardiol. 2003 Jan-Feb; 10(1):71-6. PMID: 12569334.
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      38. Lin AE, Grossfeld P, Hamilton RM, Smoot L, Gripp KW, Proud V, Weksberg R, Wheeler P, Picker J, Irons M, Zackai E, Marino B, Scott CI, Nicholson L. Further delineation of cardiac abnormalities in Costello syndrome. Am J Med Genet. 2002 Aug 01; 111(2):115-29. PMID: 12210337.
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      39. Sklansky M, Tang A, Levy D, Grossfeld P, Kashani I, Shaughnessy R, Rothman A. Maternal psychological impact of fetal echocardiography. J Am Soc Echocardiogr. 2002 Feb; 15(2):159-66. PMID: 11836491.
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      40. Sklansky MS, Levy DJ, Elias WT, Morris P, Grossfeld P, Kashani IA, Shaughnessy RD, Rothman A. Reptilian echocardiography: insights into ontogeny and phylogeny? Echocardiography. 2001 Aug; 18(6):531-3. PMID: 11567602.
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      41. Hart A, Melet F, Grossfeld P, Chien K, Jones C, Tunnacliffe A, Favier R, Bernstein A. Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity. 2000 Aug; 13(2):167-77. PMID: 10981960.
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      42. Jones C, Müllenbach R, Grossfeld P, Auer R, Favier R, Chien K, James M, Tunnacliffe A, Cotter F. Co-localisation of CCG repeats and chromosome deletion breakpoints in Jacobsen syndrome: evidence for a common mechanism of chromosome breakage. Hum Mol Genet. 2000 May 01; 9(8):1201-8. PMID: 10767345.
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      43. Grossfeld P. The genetics of hypoplastic left heart syndrome. Cardiol Young. 1999 Nov; 9(6):627-32. PMID: 10593278.
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      44. Gaudray P, Carle GF, Gerhard DS, Gessler M, Mannens MM, Athanasiou M, Bliek J, Calender A, Debelenko LV, Devignes M, Evans GA, Favier R, Forbes S, Gaudray G, Gawin B, Gordon M, Grimmond S, Grossfeld P, Harris J, Hattori M, Hosoda F, Hummerich H, James M, Kalla J, Katsanis N. Report of the Sixth International Workshop on Human Chromosome 11 Mapping 1998. Nice, France, May 2-5, 1998. Cytogenet Cell Genet. 1999; 86(3-4):167-86. PMID: 10575203.
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      45. Grossfeld P, Lucas VW, Sklansky MS, Kashani IA, Rothman A. Familial occurrence of pulmonary atresia with intact ventricular septum. Am J Med Genet. 1997 Oct 31; 72(3):294-6. PMID: 9332657.
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      46. Grossfeld P, Friedman DB, Levine BD. Traumatic myocardial infarction during competitive volleyball: a case report. Med Sci Sports Exerc. 1993 Aug; 25(8):901-3. PMID: 8371649.
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      47. Gordon JA, Dillingham MA, Guggenheim SJ, Grossfeld P, Anderson RJ. The renal concentrating defect after gentamicin administration in the rat. J Lab Clin Med. 1983 Jun; 101(6):903-10. PMID: 6574196.
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