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NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2024 Jan; 25(1):455.
Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 38216786; PMCID: PMC10897131.
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HumansAnimalsCells
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NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2022 11 07; 23(11):e54446.
Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 36194627; PMCID: PMC9638850.
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25 Fields:
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AnimalsCells
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NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH. Hepatology. 2022 09; 76(3):727-741.
Calcagno DM, Chu A, Gaul S, Taghdiri N, Toomu A, Leszczynska A, Kaufmann B, Papouchado B, Wree A, Geisler L, Hoffman HM, Feldstein AE, King KR. PMID: 34997987; PMCID: PMC10176600.
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20 Fields:
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HumansAnimals
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ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model. JCI Insight. 2020 01 30; 5(2).
Schuster-Gaul S, Geisler LJ, McGeough MD, Johnson CD, Zagorska A, Li L, Wree A, Barry V, Mikaelian I, Jih LJ, Papouchado BG, Budas G, Hoffman HM, Feldstein AE. PMID: 31996485; PMCID: PMC7098717.
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32 Fields:
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AnimalsCells
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NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice. Hepatology. 2019 02; 69(2):845-859.
Inzaugarat ME, Johnson CD, Holtmann TM, McGeough MD, Trautwein C, Papouchado BG, Schwabe R, Hoffman HM, Wree A, Feldstein AE. PMID: 30180270; PMCID: PMC6351190.
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67 Fields:
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AnimalsCells
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Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice. J Lipid Res. 2018 09; 59(9):1597-1609.
Schuster S, Johnson CD, Hennebelle M, Holtmann T, Taha AY, Kirpich IA, Eguchi A, Ramsden CE, Papouchado BG, McClain CJ, Feldstein AE. PMID: 30084831; PMCID: PMC6121934.
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41 Fields:
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AnimalsCells
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NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice. Hepatology. 2018 02; 67(2):736-749.
Wree A, McGeough MD, Inzaugarat ME, Eguchi A, Schuster S, Johnson CD, Peña CA, Geisler LJ, Papouchado BG, Hoffman HM, Feldstein AE. PMID: 28902427; PMCID: PMC5849484.
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PubMed Mentions:
128 Fields:
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AnimalsCells
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Slowly Growing Right-Sided Neck Mass With Progressive Dysphagia. JAMA Otolaryngol Head Neck Surg. 2017 04 01; 143(4):419-420.
Lopez A, Papouchado B, Brumund KT. PMID: 27918788.
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Humans
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Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-γ. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):646-663.e4.
Povero D, Panera N, Eguchi A, Johnson CD, Papouchado BG, de Araujo Horcel L, Pinatel EM, Alisi A, Nobili V, Feldstein AE. PMID: 26783552; PMCID: PMC4714359.
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127 Fields:
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Redox nanoparticles as a novel treatment approach for inflammation and fibrosis associated with nonalcoholic steatohepatitis. Nanomedicine (Lond). 2015; 10(17):2697-708.
Eguchi A, Yoshitomi T, Lazic M, Johnson CD, Vong LB, Wree A, Povero D, Papouchado BG, Nagasaki Y, Feldstein AE. PMID: 26020857; PMCID: PMC4910954.
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17 Fields:
Translation:
AnimalsCells
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Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease. PLoS One. 2014; 9(12):e113651.
Povero D, Eguchi A, Li H, Johnson CD, Papouchado BG, Wree A, Messer K, Feldstein AE. PMID: 25470250; PMCID: PMC4254757.
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PubMed Mentions:
159 Fields:
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HumansAnimalsCells
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Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis. J Hepatol. 2015 Feb; 62(2):412-20.
Navarro LA, Wree A, Povero D, Berk MP, Eguchi A, Ghosh S, Papouchado BG, Erzurum SC, Feldstein AE. PMID: 25234945; PMCID: PMC4736721.
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35 Fields:
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AnimalsCells
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Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model. Dig Dis Sci. 2014 Jun; 59(6):1197-206.
Thapaliya S, Wree A, Povero D, Inzaugarat ME, Berk M, Dixon L, Papouchado BG, Feldstein AE. PMID: 24795036; PMCID: PMC4512760.
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PubMed Mentions:
62 Fields:
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AnimalsCells
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Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice. J Hepatol. 2014 Jul; 61(1):107-15.
Lazic M, Eguchi A, Berk MP, Povero D, Papouchado B, Mulya A, Johnson CD, Feldstein AE. PMID: 24681344; PMCID: PMC4712949.
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PubMed Mentions:
9 Fields:
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AnimalsCells
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Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One. 2013; 8(2):e56100.
Dixon LJ, Flask CA, Papouchado BG, Feldstein AE, Nagy LE. PMID: 23409132; PMCID: PMC3567081.
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PubMed Mentions:
98 Fields:
Translation:
Animals
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Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. Lab Invest. 2012 May; 92(5):713-23.
Dixon LJ, Berk M, Thapaliya S, Papouchado BG, Feldstein AE. PMID: 22411067; PMCID: PMC3808241.
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PubMed Mentions:
87 Fields:
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AnimalsCells
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Transcriptional profile of genes involved in oxidative stress and antioxidant defense in a dietary murine model of steatohepatitis. Antioxid Redox Signal. 2011 Jul 15; 15(2):437-45.
Gornicka A, Morris-Stiff G, Thapaliya S, Papouchado BG, Berk M, Feldstein AE. PMID: 21194384; PMCID: PMC3118609.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Silver in situ hybridization (SISH) for determination of HER2 gene status in breast carcinoma: comparison with FISH and assessment of interobserver reproducibility. Am J Surg Pathol. 2010 Jun; 34(6):767-76.
Papouchado BG, Myles J, Lloyd RV, Stoler M, Oliveira AM, Downs-Kelly E, Morey A, Bilous M, Nagle R, Prescott N, Wang L, Dragovich L, McElhinny A, Garcia CF, Ranger-Moore J, Free H, Powell W, Loftus M, Pettay J, Gaire F, Roberts C, Dietel M, Roche P, Grogan T, Tubbs R. PMID: 20421783.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Chronic alcohol exposure increases circulating bioactive oxidized phospholipids. J Biol Chem. 2010 Jul 16; 285(29):22211-20.
Yang L, Latchoumycandane C, McMullen MR, Pratt BT, Zhang R, Papouchado BG, Nagy LE, Feldstein AE, McIntyre TM. PMID: 20460374; PMCID: PMC2903350.
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29 Fields:
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HumansAnimalsCells
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Role of interleukin-6 in human nonalcoholic steatohepatitis. Response to Dogru et al. Am J Gastroenterol. 2009 Mar; 104(3):author reply 788.
Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE. PMID: 19174778.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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The role of Movat pentachrome stain and immunoglobulin G4 immunostaining in the diagnosis of autoimmune pancreatitis. Mod Pathol. 2009 Mar; 22(3):351-8.
Chu KE, Papouchado BG, Lane Z, Bronner MP. PMID: 19136927.
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4 Fields:
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Humans
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Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am J Gastroenterol. 2008 Jun; 103(6):1372-9.
Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE. PMID: 18510618.
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PubMed Mentions:
260 Fields:
Translation:
Humans
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Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas. Mod Pathol. 2005 Oct; 18(10):1329-35.
Papouchado B, Erickson LA, Rohlinger AL, Hobday TJ, Erlichman C, Ames MM, Lloyd RV. PMID: 15920550.
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PubMed Mentions:
29 Fields:
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HumansCells
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Early hepatic stellate cell activation predicts severe hepatitis C recurrence after liver transplantation. Liver Transpl. 2005 Oct; 11(10):1207-13.
Gawrieh S, Papouchado BG, Burgart LJ, Kobayashi S, Charlton MR, Gores GJ. PMID: 16184568.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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Hepatic stellate cells and fibrosis progression in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2005 Apr; 3(4):384-9.
Feldstein AE, Papouchado BG, Angulo P, Sanderson S, Adams L, Gores GJ. PMID: 15822044.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Cdx2 as a marker for neuroendocrine tumors of unknown primary sites. Endocr Pathol. 2004; 15(3):247-52.
Erickson LA, Papouchado B, Dimashkieh H, Zhang S, Nakamura N, Lloyd RV. PMID: 15640551.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Cockroach allergen-induced eosinophilic airway inflammation in HLA-DQ/human CD4(+) transgenic mice. J Immunol. 2001 Oct 15; 167(8):4627-34.
Papouchado BG, Chapoval SP, Marietta EV, Weiler CR, David CS. PMID: 11591792.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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HLA-DQ/human CD4-restricted immune response to cockroach allergens in transgenic mice. Tissue Antigens. 2000 Apr; 55(4):303-11.
Papouchado BG, Chapoval SP, Marietta EV, Weiler CR, David CS. PMID: 10852381.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Sympathetic withdrawal and forearm vasodilation during vasovagal syncope in humans. J Appl Physiol (1985). 1997 Jun; 82(6):1785-93.
Dietz NM, Halliwill JR, Spielmann JM, Lawler LA, Papouchado BG, Eickhoff TJ, Joyner MJ. PMID: 9173942.
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PubMed Mentions:
27 Fields:
Translation:
Humans