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Sushil Mahata

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0732
La Jolla CA 92093
Phone858-552-8585
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    Collapse Research 
    Collapse Research Activities and Funding
    Catestatin improves glucose homeostasis and insulin sensitivity in diet-induced obese mice
    VA I01BX003934Oct 1, 2017 - Sep 30, 2021
    Role: Principal Investigator
    Role of Chromogranin A in Metabolic Syndrome
    VA I01BX000323Apr 1, 2010 - Mar 31, 2014
    Role: Principal Investigator
    Chromaffin Cell physiology: Novel molecular approaches
    NIH/NIDA R01DA011311Sep 30, 1997 - Mar 31, 2011
    Role: Principal Investigator
    CHROMOGRANIN A--NICOTINIC SIGNALING AND DESENSITIZATION
    NIH/NIDA R29DA011311Sep 30, 1997 - Aug 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jati S, Kundu S, Chakraborty A, Mahata S, Nizet V, Sen M. Wnt5A Signaling Promotes Defense Against Bacterial Pathogens by Activating a Host Autophagy Circuit. Front Immunol. 2018; 9:679. PMID: 29686674.
      View in: PubMed
    2. Ying W, Mahata S, Bandyopadhyay GK, Zhou Z, Wollam J, Vu J, Mayoral R, Chi NW, Webster NJG, Corti A, Mahata S. Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity. Diabetes. 2018 05; 67(5):841-848. PMID: 29432123.
      View in: PubMed
    3. Hasan MK, Friedman TC, Sims C, Lee DL, Espinoza-Derout J, Ume A, Chalfant V, Lee ML, Sinha-Hikim I, Lutfy K, Liu Y, Mahata S, Sinha-Hikim AP. a7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. 2018 02 01; 159(2):931-944. PMID: 29272360.
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    4. Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata S, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. Estrogen receptor a protects pancreatic ß-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. J Biol Chem. 2018 Mar 30; 293(13):4735-4751. PMID: 29378845.
      View in: PubMed
    5. Sinha-Hikim AP, Mahata S. Editorial: Obesity, Smoking, and Fatty Liver Disease. Front Endocrinol (Lausanne). 2018; 9:1. PMID: 29403440.
      View in: PubMed
    6. Mahata S, Kiranmayi M, Mahapatra NR. Catestatin: A Master Regulator of Cardiovascular Functions. Curr Med Chem. 2018; 25(11):1352-1374. PMID: 28443506.
      View in: PubMed
    7. Sahu BS, Manna PT, Edgar JR, Antrobus R, Mahata S, Bartolomucci A, Borner GHH, Robinson MS. Role of clathrin in dense core vesicle biogenesis. Mol Biol Cell. 2017 Oct 01; 28(20):2676-2685. PMID: 28814506.
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    8. Chakraborty A, Kurati SP, Mahata S, Sundar S, Roy S, Sen M. Wnt5a Signaling Promotes Host Defense against Leishmania donovani Infection. J Immunol. 2017 08 01; 199(3):992-1002. PMID: 28659356.
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    9. Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata S. Diabetic Cardiomyopathy: An Immunometabolic Perspective. Front Endocrinol (Lausanne). 2017; 8:72. PMID: 28439258.
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    10. Wollam J, Mahata S, Riopel M, Hernandez-Carretero A, Biswas A, Bandyopadhyay GK, Chi NW, Eiden LE, Mahapatra NR, Corti A, Webster NJG, Mahata S. Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion. Cell Tissue Res. 2017 06; 368(3):487-501. PMID: 28220294.
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    11. Bandyopadhyay GK, Mahata S. Chromogranin A Regulation of Obesity and Peripheral Insulin Sensitivity. Front Endocrinol (Lausanne). 2017; 8:20. PMID: 28228748.
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    12. Ray I, Mahata S, De RK. Obesity: An Immunometabolic Perspective. Front Endocrinol (Lausanne). 2016; 7:157. PMID: 28018292.
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    13. Mayoral Monibas R, Johnson AM, Osborn O, Traves PG, Mahata S. Distinct Hepatic Macrophage Populations in Lean and Obese Mice. Front Endocrinol (Lausanne). 2016; 7:152. PMID: 27999564.
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    14. Sinha-Hikim I, Friedman TC, Falz M, Chalfant V, Hasan MK, Espinoza-Derout J, Lee DL, Sims C, Tran P, Mahata S, Sinha-Hikim AP. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell Tissue Res. 2017 04; 368(1):159-170. PMID: 27917437.
      View in: PubMed
    15. Curnis F, Dallatomasina A, Bianco M, Gasparri A, Sacchi A, Colombo B, Fiocchi M, Perani L, Venturini M, Tacchetti C, Sen S, Borges R, Dondossola E, Esposito A, Mahata S, Corti A. Regulation of tumor growth by circulating full-length chromogranin A. Oncotarget. 2016 Nov 08; 7(45):72716-72732. PMID: 27683038.
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    16. Tang K, Pasqua T, Biswas A, Mahata S, Tang J, Tang A, Bandyopadhyay GK, Sinha-Hikim AP, Chi NW, Webster NJ, Corti A, Mahata S. Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol. 2017 Feb; 232(2):137-153. PMID: 27799464.
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    17. Mahata SK, Zheng H, Mahata S, Liu X, Patel KP. Effect of heart failure on catecholamine granule morphology and storage in chromaffin cells. J Endocrinol. 2016 Sep; 230(3):309-23. PMID: 27402067; PMCID: PMC4980258 [Available on 09/01/17].
    18. Sen S, Roy S, Bandyopadhyay G, Scott B, Xiao D, Ramadoss S, Mahata S, Chaudhuri G. ?-Aminobutyric Acid Is Synthesized and Released by the Endothelium: Potential Implications. Circ Res. 2016 Aug 19; 119(5):621-34. PMID: 27354210.
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    19. Sen S, Kawahara B, Mahata S, Tsai R, Yoon A, Hwang L, Hu-Moore K, Villanueva C, Vajihuddin A, Parameshwar P, You M, Bhaskar DL, Gomez O, Faull KF, Farias-Eisner R, Chaudhuri G. Cystathionine: A novel oncometabolite in human breast cancer. Arch Biochem Biophys. 2016 08 15; 604:95-102. PMID: 27311614.
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    20. Patra M, Mahata S, Padhan DK, Sen M. CCN6 regulates mitochondrial function. J Cell Sci. 2016 07 15; 129(14):2841-51. PMID: 27252383.
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    21. Biswas N, Maihofer AX, Mir SA, Rao F, Zhang K, Khandrika S, Mahata M, Friese RS, Hightower CM, Mahata S, Baker DG, Nievergelt CM, Vaingankar SM, O'Connor DT. Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system. BMC Med Genet. 2016 Mar 11; 17:21. PMID: 26969407; PMCID: PMC4788869.
    22. Pasqua T, Mahata S, Bandyopadhyay GK, Biswas A, Perkins GA, Sinha-Hikim AP, Goldstein DS, Eiden LE, Mahata S. Erratum to: Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo. Cell Tissue Res. 2016 Mar; 363(3):823. PMID: 26809511.
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    23. Zhong L, Ding Y, Bandyopadhyay G, Waaler J, Börgeson E, Smith S, Zhang M, Phillips SA, Mahooti S, Mahata S, Shao J, Krauss S, Chi NW. The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice. Diabetologia. 2016 Mar; 59(3):582-91. PMID: 26631215.
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    24. Pasqua T, Mahata S, Bandyopadhyay GK, Biswas A, Perkins GA, Sinha-Hikim AP, Goldstein DS, Eiden LE, Mahata S. Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo. Cell Tissue Res. 2016 Mar; 363(3):693-712. PMID: 26572539.
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    25. Dominguez Rieg JA, Chirasani VR, Koepsell H, Senapati S, Mahata S, Rieg T. Regulation of intestinal SGLT1 by catestatin in hyperleptinemic type 2 diabetic mice. Lab Invest. 2016 Jan; 96(1):98-111. PMID: 26552046; PMCID: PMC4695279.
    26. Fargali S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin WJ, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata S, Osborn JW, Huntley GW, Phillips GR, Benson DL, Bartolomucci A, Salton SR. Erratum. The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB J. 2015 Jun; 29(6):2679. PMID: 26032479; PMCID: PMC4763872.
    27. Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata S, Shao J, Chessler SD, Chi NW. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015; 10(4):e0122948. PMID: 25876076; PMCID: PMC4395342.
    28. Zhang K, Mir SA, Hightower CM, Miramontes-Gonzalez JP, Maihofer AX, Chen Y, Mahata S, Nievergelt CM, Schork NJ, Freedman BI, Vaingankar SM, O'Connor DT. Molecular Mechanism for Hypertensive Renal Disease: Differential Regulation of Chromogranin A Expression at 3'-Untranslated Region Polymorphism C+87T by MicroRNA-107. J Am Soc Nephrol. 2015 Aug; 26(8):1816-25. PMID: 25392232; PMCID: PMC4520173.
    29. Penna C, Pasqua T, Amelio D, Perrelli MG, Angotti C, Tullio F, Mahata S, Tota B, Pagliaro P, Cerra MC, Angelone T. Catestatin increases the expression of anti-apoptotic and pro-angiogenetic factors in the post-ischemic hypertrophied heart of SHR. PLoS One. 2014; 9(8):e102536. PMID: 25099124; PMCID: PMC4123866.
    30. Vu CU, Siddiqui JA, Wadensweiler P, Gayen JR, Avolio E, Bandyopadhyay GK, Biswas N, Chi NW, O'Connor DT, Mahata S. Nicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice. Endocrinology. 2014 Oct; 155(10):3793-805. PMID: 25051446.
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    31. Bandyopadhyay GK, Lu M, Avolio E, Siddiqui JA, Gayen JR, Wollam J, Vu CU, Chi NW, O'Connor DT, Mahata S. Pancreastatin-dependent inflammatory signaling mediates obesity-induced insulin resistance. Diabetes. 2015 Jan; 64(1):104-16. PMID: 25048197.
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    32. Fornero S, Bassino E, Ramella R, Gallina C, Mahata S, Tota B, Levi R, Alloatti G, Gallo MP. Obligatory role for endothelial heparan sulphate proteoglycans and caveolae internalization in catestatin-dependent eNOS activation. Biomed Res Int. 2014; 2014:783623. PMID: 25136621; PMCID: PMC4127283.
    33. Fargali S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin WJ, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata S, Osborn JW, Huntley GW, Phillips GR, Benson DL, Bartolomucci A, Salton SR. The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB J. 2014 May; 28(5):2120-33. PMID: 24497580; PMCID: PMC3986843.
    34. Biswas N, Friese RS, Gayen JR, Bandyopadhyay G, Mahata S, O'Connor DT. Discovery of a novel target for the dysglycemic chromogranin A fragment pancreastatin: interaction with the chaperone GRP78 to influence metabolism. PLoS One. 2014; 9(1):e84132. PMID: 24465394; PMCID: PMC3896336.
    35. Zhang K, Biswas N, Gayen JR, Miramontes-Gonzalez JP, Hightower CM, Mustapic M, Mahata M, Huang CT, Hook VY, Mahata S, Vaingankar S, O'Connor DT. Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms. J Neurochem. 2014 Apr; 129(1):48-59. PMID: 24266713; PMCID: PMC3992281.
    36. Valicherla GR, Hossain Z, Mahata S, Gayen JR. Pancreastatin is an endogenous peptide that regulates glucose homeostasis. Physiol Genomics. 2013 Nov 15; 45(22):1060-71. PMID: 24064537.
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    37. Avolio E, Facciolo RM, Alò R, Mele M, Carelli A, Canonaco A, Mosciaro L, Talani G, Biggio G, Sanna E, Mahata S, Canonaco M. Expression variations of chromogranin A and a1,2,4 GABA(A)Rs in discrete limbic and brainstem areas rescue cardiovascular alterations. Neurosci Res. 2013 Sep-Oct; 77(1-2):8-15. PMID: 23916832.
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    38. Tsigelny IF, Kouznetsova VL, Biswas N, Mahata S, O'Connor DT. Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: virtual screening and functional testing identify novel small molecule therapeutics of hypertension. Bioorg Med Chem. 2013 Sep 15; 21(18):5855-69. PMID: 23916146.
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    39. Friese RS, Altshuler AE, Zhang K, Miramontes-Gonzalez JP, Hightower CM, Jirout ML, Salem RM, Gayen JR, Mahapatra NR, Biswas N, Cale M, Vaingankar SM, Kim HS, Courel M, Taupenot L, Ziegler MG, Schork NJ, Pravenec M, Mahata S, Schmid-Schönbein GW, O'Connor DT. MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension. Hum Mol Genet. 2013 Sep 15; 22(18):3624-40. PMID: 23674521; PMCID: PMC3749858.
    40. Borges R, Dominguez N, Smith CB, Bandyopadhyay GK, O'Connor DT, Mahata S, Bartolomucci A. Granins and catecholamines: functional interaction in chromaffin cells and adipose tissue. Adv Pharmacol. 2013; 68:93-113. PMID: 24054141.
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    41. Wei Z, Zhang K, Wen G, Balasubramanian K, Shih PA, Rao F, Friese RS, Miramontes-Gonzalez JP, Schmid-Schoenbein GW, Kim HS, Mahata S, O'Connor DT. Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs. J Hypertens. 2013 Jan; 31(1):123-33. PMID: 23149563; PMCID: PMC3615981.
    42. Biswas N, Gayen J, Mahata M, Su Y, Mahata S, O'Connor DT. Novel peptide isomer strategy for stable inhibition of catecholamine release: application to hypertension. Hypertension. 2012 Dec; 60(6):1552-9. PMID: 23129699; PMCID: PMC3523723.
    43. Mbewe-Campbell N, Wei Z, Zhang K, Friese RS, Mahata M, Schork AJ, Rao F, Chiron S, Biswas N, Kim HS, Mahata S, Waalen J, Nievergelt CM, Hook VY, O'Connor DT. Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure. J Hypertens. 2012 Oct; 30(10):1961-9. PMID: 22871890; PMCID: PMC3478326.
    44. Bandyopadhyay GK, Vu CU, Gentile S, Lee H, Biswas N, Chi NW, O'Connor DT, Mahata S. Catestatin (chromogranin A(352-372)) and novel effects on mobilization of fat from adipose tissue through regulation of adrenergic and leptin signaling. J Biol Chem. 2012 Jun 29; 287(27):23141-51. PMID: 22535963; PMCID: PMC3391131.
    45. Loh YP, Cheng Y, Mahata S, Corti A, Tota B. Chromogranin A and derived peptides in health and disease. J Mol Neurosci. 2012 Oct; 48(2):347-56. PMID: 22388654.
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    46. Mir SA, Chatterjee A, Mitra A, Pathak K, Mahata S, Sarkar S. Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart. J Biol Chem. 2012 Jan 20; 287(4):2666-77. PMID: 22157761; PMCID: PMC3268425.
    47. Angelone T, Quintieri AM, Pasqua T, Gentile S, Tota B, Mahata S, Cerra MC. Phosphodiesterase type-2 and NO-dependent S-nitrosylation mediate the cardioinhibition of the antihypertensive catestatin. Am J Physiol Heart Circ Physiol. 2012 Jan; 302(2):H431-42. PMID: 22058158.
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    48. Rao F, Chiron S, Wei Z, Fung MM, Chen Y, Wen G, Khandrika S, Ziegler MG, Benyamin B, Montgomery G, Whitfield JB, Martin NG, Waalen J, Hamilton BA, Mahata S, O'Connor DT. Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins. Am J Hypertens. 2012 Jan; 25(1):29-40. PMID: 21918574; PMCID: PMC3664223.
    49. Bartolomucci A, Possenti R, Mahata S, Fischer-Colbrie R, Loh YP, Salton SR. The extended granin family: structure, function, and biomedical implications. Endocr Rev. 2011 Dec; 32(6):755-97. PMID: 21862681; PMCID: PMC3591675.
    50. Sinha-Hikim I, Shen R, Nzenwa I, Gelfand R, Mahata S, Sinha-Hikim AP. Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure. Apoptosis. 2011 Jun; 16(6):563-73. PMID: 21424555; PMCID: PMC4701037.
    51. Mahata M, Zhang K, Gayen JR, Nandi S, Brar BK, Ghosh S, Mahapatra NR, Taupenot L, O'Connor DT, Mahata S. Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin. Cell Tissue Res. 2011 Jul; 345(1):87-102. PMID: 21597914.
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    52. Chiron S, Wei Z, Chen Y, Zhang K, Wen G, Fischer WH, Mahata S, O'Connor DT. Proteomic analysis yields an unexpected trans-acting point in control of the human sympathochromaffin phenotype. Circ Cardiovasc Genet. 2011 Aug 01; 4(4):437-45. PMID: 21551321; PMCID: PMC3319683.
    53. Bassino E, Fornero S, Gallo MP, Ramella R, Mahata S, Tota B, Levi R, Alloatti G. A novel catestatin-induced antiadrenergic mechanism triggered by the endothelial PI3K-eNOS pathway in the myocardium. Cardiovasc Res. 2011 Sep 01; 91(4):617-24. PMID: 21543385; PMCID: PMC3156905.
    54. Lu M, Sarruf DA, Talukdar S, Sharma S, Li P, Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata S, Webster NJ, Schwartz MW, Olefsky JM. Brain PPAR-? promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med. 2011 May; 17(5):618-22. PMID: 21532596; PMCID: PMC3380629.
    55. Zhang K, Chen Y, Wen G, Mahata M, Rao F, Fung MM, Vaingankar S, Biswas N, Gayen JR, Friese RS, Mahata S, Hamilton BA, O'Connor DT. Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension. Curr Hypertens Rep. 2011 Feb; 13(1):36-45. PMID: 21104344; PMCID: PMC3016145.
    56. Penna C, Alloatti G, Gallo MP, Cerra MC, Levi R, Tullio F, Bassino E, Dolgetta S, Mahata S, Tota B, Pagliaro P. Catestatin improves post-ischemic left ventricular function and decreases ischemia/reperfusion injury in heart. Cell Mol Neurobiol. 2010 Nov; 30(8):1171-9. PMID: 21104119; PMCID: PMC3008938.
    57. Biswas N, Curello E, O'Connor DT, Mahata S. Chromogranin/secretogranin proteins in murine heart: myocardial production of chromogranin A fragment catestatin (Chga(364-384)). Cell Tissue Res. 2010 Dec; 342(3):353-61. PMID: 21052719; PMCID: PMC2996542.
    58. Imbrogno S, Garofalo F, Cerra MC, Mahata S, Tota B. The catecholamine release-inhibitory peptide catestatin (chromogranin A344-363) modulates myocardial function in fish. J Exp Biol. 2010 Nov 01; 213(Pt 21):3636-43. PMID: 20952611.
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    59. Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata S, Hamilton BA, O'Connor DT. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cell Mol Neurobiol. 2010 Nov; 30(8):1395-400. PMID: 21061160; PMCID: PMC3008929.
    60. Mahata S, Mahata M, Fung MM, O'Connor DT. Reprint of: Catestatin: a multifunctional peptide from chromogranin A. Regul Pept. 2010 Nov 30; 165(1):52-62. PMID: 20965217.
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    61. Theurl M, Schgoer W, Albrecht K, Jeschke J, Egger M, Beer AG, Vasiljevic D, Rong S, Wolf AM, Bahlmann FH, Patsch JR, Wolf D, Schratzberger P, Mahata S, Kirchmair R. The neuropeptide catestatin acts as a novel angiogenic cytokine via a basic fibroblast growth factor-dependent mechanism. Circ Res. 2010 Nov 26; 107(11):1326-35. PMID: 20930149.
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    62. Chen Y, Salem RM, Rao F, Fung MM, Bhatnagar V, Pandey B, Mahata M, Waalen J, Nievergelt CM, Lipkowitz MS, Hamilton BA, Mahata S, O'Connor DT. Common charge-shift mutation Glu65Lys in K+ channel ß1-Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease. Am J Nephrol. 2010; 32(5):414-24. PMID: 20861615; PMCID: PMC2975731.
    63. Fung MM, Rao F, Poddar S, Mahata M, Khandrika S, Mahata S, O'Connor DT. Early inflammatory and metabolic changes in association with AGTR1 polymorphisms in prehypertensive subjects. Am J Hypertens. 2011 Feb; 24(2):225-33. PMID: 20864943; PMCID: PMC3101264.
    64. Chen Y, Zhang K, Wen G, Rao F, Sanchez AP, Wang L, Rodriguez-Flores JL, Mahata M, Mahata S, Waalen J, Ziegler MG, Hamilton BA, O'Connor DT. Human dopamine ß-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure. Am J Hypertens. 2011 Jan; 24(1):24-32. PMID: 20814407; PMCID: PMC4906639.
    65. Gayen JR, Zhang K, RamachandraRao SP, Mahata M, Chen Y, Kim HS, Naviaux RK, Sharma K, Mahata S, O'Connor DT. Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene. Circ Cardiovasc Genet. 2010 Oct; 3(5):414-25. PMID: 20729505; PMCID: PMC3052689.
    66. Gu Y, Zhang K, Biswas N, Friese RS, Lin DH, Mahata S, Hoshijima M, O'Connor DT, Peterson KL, Brar BK. Urocortin 2 lowers blood pressure and reduces plasma catecholamine levels in mice with hyperadrenergic activity. Endocrinology. 2010 Oct; 151(10):4820-9. PMID: 20668031; PMCID: PMC2946150.
    67. Brar BK, Helgeland E, Mahata S, Zhang K, O'Connor DT, Helle KB, Jonassen AK. Human catestatin peptides differentially regulate infarct size in the ischemic-reperfused rat heart. Regul Pept. 2010 Nov 30; 165(1):63-70. PMID: 20655339; PMCID: PMC2998543.
    68. Chen Y, Lipkowitz MS, Salem RM, Fung MM, Bhatnagar V, Mahata M, Nievergelt CM, Rao F, Mahata S, Schork NJ, Hicks PJ, Bowden DW, Freedman BI, Brophy VH, O'Connor DT. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. Am J Nephrol. 2010; 32(1):23-30. PMID: 20484896; PMCID: PMC2914391.
    69. Radek KA, Elias PM, Taupenot L, Mahata S, O'Connor DT, Gallo RL. Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production. Cell Host Microbe. 2010 Apr 22; 7(4):277-89. PMID: 20413096; PMCID: PMC2916230.
    70. Dev NB, Gayen JR, O'Connor DT, Mahata S. Chromogranin a and the autonomic system: decomposition of heart rate variability and rescue by its catestatin fragment. Endocrinology. 2010 Jun; 151(6):2760-8. PMID: 20410203; PMCID: PMC2875835.
    71. Zhang K, Rao F, Wang L, Rana BK, Ghosh S, Mahata M, Salem RM, Rodriguez-Flores JL, Fung MM, Waalen J, Tayo B, Taupenot L, Mahata S, O'Connor DT. Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension. J Am Coll Cardiol. 2010 Apr 06; 55(14):1463-75. PMID: 20359597; PMCID: PMC2889490.
    72. Vaingankar SM, Li Y, Biswas N, Gayen J, Choksi S, Rao F, Ziegler MG, Mahata S, O'Connor DT. Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses. J Hypertens. 2010 Apr; 28(4):817-25. PMID: 20139771; PMCID: PMC2947860.
    73. Rodríguez-Flores JL, Zhang K, Kang SW, Wen G, Ghosh S, Friese RS, Mahata S, Subramaniam S, Hamilton BA, O'Connor DT. Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach. Mamm Genome. 2010 Apr; 21(3-4):195-204. PMID: 20204374; PMCID: PMC2844968.
    74. Stadinski BD, Delong T, Reisdorph N, Reisdorph R, Powell RL, Armstrong M, Piganelli JD, Barbour G, Bradley B, Crawford F, Marrack P, Mahata S, Kappler JW, Haskins K. Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol. 2010 Mar; 11(3):225-31. PMID: 20139986; PMCID: PMC3166626.
    75. Mahata S, Mahata M, Fung MM, O'Connor DT. Catestatin: a multifunctional peptide from chromogranin A. Regul Pept. 2010 Jun 08; 162(1-3):33-43. PMID: 20116404; PMCID: PMC2866790.
    76. Alam A, O'Connor DT, Perianayagam MC, Kolyada AY, Chen Y, Rao F, Mahata M, Mahata S, Liangos O, Jaber BL. Phenylethanolamine N-methyltransferase gene polymorphisms and adverse outcomes in acute kidney injury. Nephron Clin Pract. 2010; 114(4):c253-9. PMID: 20090367; PMCID: PMC2865401.
    77. Courel M, Soler-Jover A, Rodriguez-Flores JL, Mahata S, Elias S, Montero-Hadjadje M, Anouar Y, Giuly RJ, O'Connor DT, Taupenot L. Pro-hormone secretogranin II regulates dense core secretory granule biogenesis in catecholaminergic cells. J Biol Chem. 2010 Mar 26; 285(13):10030-43. PMID: 20061385; PMCID: PMC2843166.
    78. Fung MM, Salem RM, Mehtani P, Thomas B, Lu CF, Perez B, Rao F, Stridsberg M, Ziegler MG, Mahata S, O'Connor DT. Direct vasoactive effects of the chromogranin A (CHGA) peptide catestatin in humans in vivo. Clin Exp Hypertens. 2010; 32(5):278-87. PMID: 20662728; PMCID: PMC3109075.
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    82. Shih PB, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata S, Hamilton BA, O'Connor DT. Peptide YY (PYY) Gene Polymorphisms in the 3'-Untranslated Region and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo. Endocr Rev. 2009 Dec 01; 30(7):934. PMID: 28199513.
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    86. Wang L, Rao F, Zhang K, Mahata M, Rodriguez-Flores JL, Fung MM, Waalen J, Cockburn MG, Hamilton BA, Mahata S, O'Connor DT. Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo. J Am Coll Cardiol. 2009 Sep 01; 54(10):944-54. PMID: 19712806; PMCID: PMC2792636.
    87. Gayen JR, Saberi M, Schenk S, Biswas N, Vaingankar SM, Cheung WW, Najjar SM, O'Connor DT, Bandyopadhyay G, Mahata S. A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem. 2009 Oct 16; 284(42):28498-509. PMID: 19706599; PMCID: PMC2781393.
    88. Rana BK, Wessel J, Mahboubi V, Rao F, Haeller J, Gayen JR, Eskin E, Valle AM, Das M, Mahata S, Taupenot L, Stridsberg M, Talley TT, Ziegler MG, Smith DW, Schork NJ, O'Connor DT, Taylor P. Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs. J Pharmacol Exp Ther. 2009 Nov; 331(2):419-28. PMID: 19671882; PMCID: PMC2775266.
    89. Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung MM, Zhang K, Stridsberg M, Ziegler MG, Hamilton BA, Lipkowitz MS, Taupenot L, Nievergelt C, Mahata S, O'Connor DT. Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis. J Am Soc Nephrol. 2009 Jul; 20(7):1623-32. PMID: 19520754; PMCID: PMC2709688.
    90. Biswas N, Rodriguez-Flores JL, Courel M, Gayen JR, Vaingankar SM, Mahata M, Torpey JW, Taupenot L, O'Connor DT, Mahata S. Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides. Endocrinology. 2009 Aug; 150(8):3547-57. PMID: 19372204; PMCID: PMC2717865.
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    93. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata S, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. PMID: 19033658; PMCID: PMC2575833.
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    95. Egger M, Beer AG, Theurl M, Schgoer W, Hotter B, Tatarczyk T, Vasiljevic D, Frauscher S, Marksteiner J, Patsch JR, Schratzberger P, Djanani AM, Mahata S, Kirchmair R. Monocyte migration: a novel effect and signaling pathways of catestatin. Eur J Pharmacol. 2008 Nov 19; 598(1-3):104-11. PMID: 18834877.
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    97. Mahapatra NR, Taupenot L, Courel M, Mahata S, O'Connor DT. The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. Biochemistry. 2008 Jul 08; 47(27):7167-78. PMID: 18549247; PMCID: PMC2576284.
    98. Angelone T, Quintieri AM, Brar BK, Limchaiyawat PT, Tota B, Mahata S, Cerra MC. The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism. Endocrinology. 2008 Oct; 149(10):4780-93. PMID: 18535098; PMCID: PMC2582908.
    99. Vallon V, Eraly SA, Wikoff WR, Rieg T, Kaler G, Truong DM, Ahn SY, Mahapatra NR, Mahata S, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, Nigam SK. Organic anion transporter 3 contributes to the regulation of blood pressure. J Am Soc Nephrol. 2008 Sep; 19(9):1732-40. PMID: 18508962; PMCID: PMC2518443.
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    105. Radek KA, Lopez-Garcia B, Hupe M, Niesman IR, Elias PM, Taupenot L, Mahata S, O'Connor DT, Gallo RL. The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury. J Invest Dermatol. 2008 Jun; 128(6):1525-34. PMID: 18185531; PMCID: PMC2757066.
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    111. Wen G, Wessel J, Zhou W, Ehret GB, Rao F, Stridsberg M, Mahata S, Gent PM, Das M, Cooper RS, Chakravarti A, Zhou H, Schork NJ, O'connor DT, Hamilton BA. An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension. Hum Mol Genet. 2007 Jul 15; 16(14):1752-64. PMID: 17584765; PMCID: PMC2695823.
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    125. Fries RS, Mahboubi P, Mahapatra NR, Mahata S, Schork NJ, Schmid-Schoenbein GW, O'Connor DT. Neuroendocrine transcriptome in genetic hypertension: multiple changes in diverse adrenal physiological systems. Hypertension. 2004 Jun; 43(6):1301-11. PMID: 15166183.
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    128. Prommegger R, Ensinger C, Adlassnig C, Vaingankar S, Mahata S, Marksteiner J, Margreiter R. Catestatin--a novel neuropeptide in carcinoid tumors of the appendix. Anticancer Res. 2004 Jan-Feb; 24(1):311-6. PMID: 15015613.
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    129. Lechner T, Adlassnig C, Humpel C, Kaufmann WA, Maier H, Reinstadler-Kramer K, Hinterhölzl J, Mahata S, Jellinger KA, Marksteiner J. Chromogranin peptides in Alzheimer's disease. Exp Gerontol. 2004 Jan; 39(1):101-13. PMID: 14724070.
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    131. Lee JC, Taylor CV, Gaucher SP, Toneff T, Taupenot L, Yasothornsrikul S, Mahata S, Sei C, Parmer RJ, Neveu JM, Lane WS, Gibson BW, O'Connor DT, Hook VY. Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells. Biochemistry. 2003 Jun 17; 42(23):6938-46. PMID: 12795588.
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    136. Bao X, Kennedy B, Enns R, Mahata M, Mahata S, O'Connor D, Ziegler MG. A truncated mouse phenylethanolamine N-methyltransferase splice variant with dominant-negative activity. Ann N Y Acad Sci. 2002 Oct; 971:89-91. PMID: 12438096.
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    137. Laslop A, Mahata S. Neuropeptides and chromogranins: session overview. Ann N Y Acad Sci. 2002 Oct; 971:294-9. PMID: 12438139.
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    138. Cadman PE, Rao F, Mahata S, O'Connor DT. Studies of the dysglycemic peptide, pancreastatin, using a human forearm model. Ann N Y Acad Sci. 2002 Oct; 971:528-9. PMID: 12438174.
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    140. Mahata M, Mahapatra NR, O'Connor DT, Mahata S. Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells. Mol Pharmacol. 2002 Jun; 61(6):1340-7. PMID: 12021395.
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