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Sushil Mahata

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0732
La Jolla CA 92093
Phone858-552-8585
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    Collapse Research 
    Collapse Research Activities and Funding
    Catestatin improves glucose homeostasis and insulin sensitivity in diet-induced obese mice
    VA I01BX003934Oct 1, 2017 - Sep 30, 2021
    Role: Principal Investigator
    Role of Chromogranin A in Metabolic Syndrome
    VA I01BX000323Apr 1, 2010 - Mar 31, 2014
    Role: Principal Investigator
    Chromaffin Cell physiology: Novel molecular approaches
    NIH/NIDA R01DA011311Sep 30, 1997 - Mar 31, 2011
    Role: Principal Investigator
    CHROMOGRANIN A--NICOTINIC SIGNALING AND DESENSITIZATION
    NIH/NIDA R29DA011311Sep 30, 1997 - Aug 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. McWherter C, Choi YJ, Serrano RL, Mahata SK, Terkeltaub R, Liu-Bryan R. Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling. Arthritis Res Ther. 2018 Sep 06; 20(1):204. PMID: 30189890.
      View in: PubMed
    2. Jati S, Kundu S, Chakraborty A, Mahata SK, Nizet V, Sen M. Wnt5A Signaling Promotes Defense Against Bacterial Pathogens by Activating a Host Autophagy Circuit. Front Immunol. 2018; 9:679. PMID: 29686674.
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    3. Ying W, Mahata S, Bandyopadhyay GK, Zhou Z, Wollam J, Vu J, Mayoral R, Chi NW, Webster NJG, Corti A, Mahata SK. Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity. Diabetes. 2018 05; 67(5):841-848. PMID: 29432123.
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    4. Hasan MK, Friedman TC, Sims C, Lee DL, Espinoza-Derout J, Ume A, Chalfant V, Lee ML, Sinha-Hikim I, Lutfy K, Liu Y, Mahata SK, Sinha-Hikim AP. a7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. 2018 02 01; 159(2):931-944. PMID: 29272360.
      View in: PubMed
    5. Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. Estrogen receptor a protects pancreatic ß-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. J Biol Chem. 2018 Mar 30; 293(13):4735-4751. PMID: 29378845.
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    6. Sinha-Hikim AP, Mahata SK. Editorial: Obesity, Smoking, and Fatty Liver Disease. Front Endocrinol (Lausanne). 2018; 9:1. PMID: 29403440.
      View in: PubMed
    7. Mahata SK, Kiranmayi M, Mahapatra NR. Catestatin: A Master Regulator of Cardiovascular Functions. Curr Med Chem. 2018; 25(11):1352-1374. PMID: 28443506.
      View in: PubMed
    8. Sahu BS, Manna PT, Edgar JR, Antrobus R, Mahata SK, Bartolomucci A, Borner GHH, Robinson MS. Role of clathrin in dense core vesicle biogenesis. Mol Biol Cell. 2017 Oct 01; 28(20):2676-2685. PMID: 28814506.
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    9. Chakraborty A, Kurati SP, Mahata SK, Sundar S, Roy S, Sen M. Wnt5a Signaling Promotes Host Defense against Leishmania donovani Infection. J Immunol. 2017 08 01; 199(3):992-1002. PMID: 28659356.
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    10. Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK. Diabetic Cardiomyopathy: An Immunometabolic Perspective. Front Endocrinol (Lausanne). 2017; 8:72. PMID: 28439258.
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    11. Wollam J, Mahata S, Riopel M, Hernandez-Carretero A, Biswas A, Bandyopadhyay GK, Chi NW, Eiden LE, Mahapatra NR, Corti A, Webster NJG, Mahata SK. Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion. Cell Tissue Res. 2017 06; 368(3):487-501. PMID: 28220294.
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    12. Bandyopadhyay GK, Mahata SK. Chromogranin A Regulation of Obesity and Peripheral Insulin Sensitivity. Front Endocrinol (Lausanne). 2017; 8:20. PMID: 28228748.
      View in: PubMed
    13. Ray I, Mahata SK, De RK. Obesity: An Immunometabolic Perspective. Front Endocrinol (Lausanne). 2016; 7:157. PMID: 28018292.
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    14. Mayoral Monibas R, Johnson AM, Osborn O, Traves PG, Mahata SK. Distinct Hepatic Macrophage Populations in Lean and Obese Mice. Front Endocrinol (Lausanne). 2016; 7:152. PMID: 27999564.
      View in: PubMed
    15. Sinha-Hikim I, Friedman TC, Falz M, Chalfant V, Hasan MK, Espinoza-Derout J, Lee DL, Sims C, Tran P, Mahata SK, Sinha-Hikim AP. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell Tissue Res. 2017 04; 368(1):159-170. PMID: 27917437.
      View in: PubMed
    16. Curnis F, Dallatomasina A, Bianco M, Gasparri A, Sacchi A, Colombo B, Fiocchi M, Perani L, Venturini M, Tacchetti C, Sen S, Borges R, Dondossola E, Esposito A, Mahata SK, Corti A. Regulation of tumor growth by circulating full-length chromogranin A. Oncotarget. 2016 Nov 08; 7(45):72716-72732. PMID: 27683038.
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    17. Tang K, Pasqua T, Biswas A, Mahata S, Tang J, Tang A, Bandyopadhyay GK, Sinha-Hikim AP, Chi NW, Webster NJ, Corti A, Mahata SK. Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol. 2017 Feb; 232(2):137-153. PMID: 27799464.
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    18. Mahata SK, Zheng H, Mahata S, Liu X, Patel KP. Effect of heart failure on catecholamine granule morphology and storage in chromaffin cells. J Endocrinol. 2016 Sep; 230(3):309-23. PMID: 27402067; PMCID: PMC4980258 [Available on 09/01/17].
    19. Sen S, Roy S, Bandyopadhyay G, Scott B, Xiao D, Ramadoss S, Mahata SK, Chaudhuri G. ?-Aminobutyric Acid Is Synthesized and Released by the Endothelium: Potential Implications. Circ Res. 2016 Aug 19; 119(5):621-34. PMID: 27354210.
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    20. Sen S, Kawahara B, Mahata SK, Tsai R, Yoon A, Hwang L, Hu-Moore K, Villanueva C, Vajihuddin A, Parameshwar P, You M, Bhaskar DL, Gomez O, Faull KF, Farias-Eisner R, Chaudhuri G. Cystathionine: A novel oncometabolite in human breast cancer. Arch Biochem Biophys. 2016 08 15; 604:95-102. PMID: 27311614.
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    21. Patra M, Mahata SK, Padhan DK, Sen M. CCN6 regulates mitochondrial function. J Cell Sci. 2016 07 15; 129(14):2841-51. PMID: 27252383.
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    22. Biswas N, Maihofer AX, Mir SA, Rao F, Zhang K, Khandrika S, Mahata M, Friese RS, Hightower CM, Mahata SK, Baker DG, Nievergelt CM, Vaingankar SM, O'Connor DT. Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system. BMC Med Genet. 2016 Mar 11; 17:21. PMID: 26969407; PMCID: PMC4788869.
    23. Pasqua T, Mahata S, Bandyopadhyay GK, Biswas A, Perkins GA, Sinha-Hikim AP, Goldstein DS, Eiden LE, Mahata SK. Erratum to: Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo. Cell Tissue Res. 2016 Mar; 363(3):823. PMID: 26809511.
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    24. Zhong L, Ding Y, Bandyopadhyay G, Waaler J, Börgeson E, Smith S, Zhang M, Phillips SA, Mahooti S, Mahata SK, Shao J, Krauss S, Chi NW. The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice. Diabetologia. 2016 Mar; 59(3):582-91. PMID: 26631215.
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    25. Pasqua T, Mahata S, Bandyopadhyay GK, Biswas A, Perkins GA, Sinha-Hikim AP, Goldstein DS, Eiden LE, Mahata SK. Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo. Cell Tissue Res. 2016 Mar; 363(3):693-712. PMID: 26572539.
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    26. Dominguez Rieg JA, Chirasani VR, Koepsell H, Senapati S, Mahata SK, Rieg T. Regulation of intestinal SGLT1 by catestatin in hyperleptinemic type 2 diabetic mice. Lab Invest. 2016 Jan; 96(1):98-111. PMID: 26552046; PMCID: PMC4695279.
    27. Fargali S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin WJ, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata SK, Osborn JW, Huntley GW, Phillips GR, Benson DL, Bartolomucci A, Salton SR. Erratum. The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB J. 2015 Jun; 29(6):2679. PMID: 26032479; PMCID: PMC4763872.
    28. Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler SD, Chi NW. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015; 10(4):e0122948. PMID: 25876076; PMCID: PMC4395342.
    29. Zhang K, Mir SA, Hightower CM, Miramontes-Gonzalez JP, Maihofer AX, Chen Y, Mahata SK, Nievergelt CM, Schork NJ, Freedman BI, Vaingankar SM, O'Connor DT. Molecular Mechanism for Hypertensive Renal Disease: Differential Regulation of Chromogranin A Expression at 3'-Untranslated Region Polymorphism C+87T by MicroRNA-107. J Am Soc Nephrol. 2015 Aug; 26(8):1816-25. PMID: 25392232; PMCID: PMC4520173.
    30. Penna C, Pasqua T, Amelio D, Perrelli MG, Angotti C, Tullio F, Mahata SK, Tota B, Pagliaro P, Cerra MC, Angelone T. Catestatin increases the expression of anti-apoptotic and pro-angiogenetic factors in the post-ischemic hypertrophied heart of SHR. PLoS One. 2014; 9(8):e102536. PMID: 25099124; PMCID: PMC4123866.
    31. Vu CU, Siddiqui JA, Wadensweiler P, Gayen JR, Avolio E, Bandyopadhyay GK, Biswas N, Chi NW, O'Connor DT, Mahata SK. Nicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice. Endocrinology. 2014 Oct; 155(10):3793-805. PMID: 25051446.
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    32. Bandyopadhyay GK, Lu M, Avolio E, Siddiqui JA, Gayen JR, Wollam J, Vu CU, Chi NW, O'Connor DT, Mahata SK. Pancreastatin-dependent inflammatory signaling mediates obesity-induced insulin resistance. Diabetes. 2015 Jan; 64(1):104-16. PMID: 25048197.
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    33. Fornero S, Bassino E, Ramella R, Gallina C, Mahata SK, Tota B, Levi R, Alloatti G, Gallo MP. Obligatory role for endothelial heparan sulphate proteoglycans and caveolae internalization in catestatin-dependent eNOS activation. Biomed Res Int. 2014; 2014:783623. PMID: 25136621; PMCID: PMC4127283.
    34. Fargali S, Garcia AL, Sadahiro M, Jiang C, Janssen WG, Lin WJ, Cogliani V, Elste A, Mortillo S, Cero C, Veitenheimer B, Graiani G, Pasinetti GM, Mahata SK, Osborn JW, Huntley GW, Phillips GR, Benson DL, Bartolomucci A, Salton SR. The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB J. 2014 May; 28(5):2120-33. PMID: 24497580; PMCID: PMC3986843.
    35. Biswas N, Friese RS, Gayen JR, Bandyopadhyay G, Mahata SK, O'Connor DT. Discovery of a novel target for the dysglycemic chromogranin A fragment pancreastatin: interaction with the chaperone GRP78 to influence metabolism. PLoS One. 2014; 9(1):e84132. PMID: 24465394; PMCID: PMC3896336.
    36. Zhang K, Biswas N, Gayen JR, Miramontes-Gonzalez JP, Hightower CM, Mustapic M, Mahata M, Huang CT, Hook VY, Mahata SK, Vaingankar S, O'Connor DT. Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms. J Neurochem. 2014 Apr; 129(1):48-59. PMID: 24266713; PMCID: PMC3992281.
    37. Valicherla GR, Hossain Z, Mahata SK, Gayen JR. Pancreastatin is an endogenous peptide that regulates glucose homeostasis. Physiol Genomics. 2013 Nov 15; 45(22):1060-71. PMID: 24064537.
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    38. Avolio E, Facciolo RM, Alò R, Mele M, Carelli A, Canonaco A, Mosciaro L, Talani G, Biggio G, Sanna E, Mahata SK, Canonaco M. Expression variations of chromogranin A and a1,2,4 GABA(A)Rs in discrete limbic and brainstem areas rescue cardiovascular alterations. Neurosci Res. 2013 Sep-Oct; 77(1-2):8-15. PMID: 23916832.
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    39. Tsigelny IF, Kouznetsova VL, Biswas N, Mahata SK, O'Connor DT. Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: virtual screening and functional testing identify novel small molecule therapeutics of hypertension. Bioorg Med Chem. 2013 Sep 15; 21(18):5855-69. PMID: 23916146.
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    40. Friese RS, Altshuler AE, Zhang K, Miramontes-Gonzalez JP, Hightower CM, Jirout ML, Salem RM, Gayen JR, Mahapatra NR, Biswas N, Cale M, Vaingankar SM, Kim HS, Courel M, Taupenot L, Ziegler MG, Schork NJ, Pravenec M, Mahata SK, Schmid-Schönbein GW, O'Connor DT. MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension. Hum Mol Genet. 2013 Sep 15; 22(18):3624-40. PMID: 23674521; PMCID: PMC3749858.
    41. Borges R, Dominguez N, Smith CB, Bandyopadhyay GK, O'Connor DT, Mahata SK, Bartolomucci A. Granins and catecholamines: functional interaction in chromaffin cells and adipose tissue. Adv Pharmacol. 2013; 68:93-113. PMID: 24054141.
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    42. Wei Z, Zhang K, Wen G, Balasubramanian K, Shih PA, Rao F, Friese RS, Miramontes-Gonzalez JP, Schmid-Schoenbein GW, Kim HS, Mahata SK, O'Connor DT. Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs. J Hypertens. 2013 Jan; 31(1):123-33. PMID: 23149563; PMCID: PMC3615981.
    43. Biswas N, Gayen J, Mahata M, Su Y, Mahata SK, O'Connor DT. Novel peptide isomer strategy for stable inhibition of catecholamine release: application to hypertension. Hypertension. 2012 Dec; 60(6):1552-9. PMID: 23129699; PMCID: PMC3523723.
    44. Mbewe-Campbell N, Wei Z, Zhang K, Friese RS, Mahata M, Schork AJ, Rao F, Chiron S, Biswas N, Kim HS, Mahata SK, Waalen J, Nievergelt CM, Hook VY, O'Connor DT. Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure. J Hypertens. 2012 Oct; 30(10):1961-9. PMID: 22871890; PMCID: PMC3478326.
    45. Bandyopadhyay GK, Vu CU, Gentile S, Lee H, Biswas N, Chi NW, O'Connor DT, Mahata SK. Catestatin (chromogranin A(352-372)) and novel effects on mobilization of fat from adipose tissue through regulation of adrenergic and leptin signaling. J Biol Chem. 2012 Jun 29; 287(27):23141-51. PMID: 22535963; PMCID: PMC3391131.
    46. Loh YP, Cheng Y, Mahata SK, Corti A, Tota B. Chromogranin A and derived peptides in health and disease. J Mol Neurosci. 2012 Oct; 48(2):347-56. PMID: 22388654.
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    47. Mir SA, Chatterjee A, Mitra A, Pathak K, Mahata SK, Sarkar S. Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart. J Biol Chem. 2012 Jan 20; 287(4):2666-77. PMID: 22157761; PMCID: PMC3268425.
    48. Angelone T, Quintieri AM, Pasqua T, Gentile S, Tota B, Mahata SK, Cerra MC. Phosphodiesterase type-2 and NO-dependent S-nitrosylation mediate the cardioinhibition of the antihypertensive catestatin. Am J Physiol Heart Circ Physiol. 2012 Jan; 302(2):H431-42. PMID: 22058158.
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    49. Rao F, Chiron S, Wei Z, Fung MM, Chen Y, Wen G, Khandrika S, Ziegler MG, Benyamin B, Montgomery G, Whitfield JB, Martin NG, Waalen J, Hamilton BA, Mahata SK, O'Connor DT. Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins. Am J Hypertens. 2012 Jan; 25(1):29-40. PMID: 21918574; PMCID: PMC3664223.
    50. Bartolomucci A, Possenti R, Mahata SK, Fischer-Colbrie R, Loh YP, Salton SR. The extended granin family: structure, function, and biomedical implications. Endocr Rev. 2011 Dec; 32(6):755-97. PMID: 21862681; PMCID: PMC3591675.
    51. Sinha-Hikim I, Shen R, Nzenwa I, Gelfand R, Mahata SK, Sinha-Hikim AP. Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure. Apoptosis. 2011 Jun; 16(6):563-73. PMID: 21424555; PMCID: PMC4701037.
    52. Mahata M, Zhang K, Gayen JR, Nandi S, Brar BK, Ghosh S, Mahapatra NR, Taupenot L, O'Connor DT, Mahata SK. Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin. Cell Tissue Res. 2011 Jul; 345(1):87-102. PMID: 21597914.
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    53. Chiron S, Wei Z, Chen Y, Zhang K, Wen G, Fischer WH, Mahata SK, O'Connor DT. Proteomic analysis yields an unexpected trans-acting point in control of the human sympathochromaffin phenotype. Circ Cardiovasc Genet. 2011 Aug 01; 4(4):437-45. PMID: 21551321; PMCID: PMC3319683.
    54. Bassino E, Fornero S, Gallo MP, Ramella R, Mahata SK, Tota B, Levi R, Alloatti G. A novel catestatin-induced antiadrenergic mechanism triggered by the endothelial PI3K-eNOS pathway in the myocardium. Cardiovasc Res. 2011 Sep 01; 91(4):617-24. PMID: 21543385; PMCID: PMC3156905.
    55. Lu M, Sarruf DA, Talukdar S, Sharma S, Li P, Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata SK, Webster NJ, Schwartz MW, Olefsky JM. Brain PPAR-? promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med. 2011 May; 17(5):618-22. PMID: 21532596; PMCID: PMC3380629.
    56. Zhang K, Chen Y, Wen G, Mahata M, Rao F, Fung MM, Vaingankar S, Biswas N, Gayen JR, Friese RS, Mahata SK, Hamilton BA, O'Connor DT. Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension. Curr Hypertens Rep. 2011 Feb; 13(1):36-45. PMID: 21104344; PMCID: PMC3016145.
    57. Penna C, Alloatti G, Gallo MP, Cerra MC, Levi R, Tullio F, Bassino E, Dolgetta S, Mahata SK, Tota B, Pagliaro P. Catestatin improves post-ischemic left ventricular function and decreases ischemia/reperfusion injury in heart. Cell Mol Neurobiol. 2010 Nov; 30(8):1171-9. PMID: 21104119; PMCID: PMC3008938.
    58. Biswas N, Curello E, O'Connor DT, Mahata SK. Chromogranin/secretogranin proteins in murine heart: myocardial production of chromogranin A fragment catestatin (Chga(364-384)). Cell Tissue Res. 2010 Dec; 342(3):353-61. PMID: 21052719; PMCID: PMC2996542.
    59. Imbrogno S, Garofalo F, Cerra MC, Mahata SK, Tota B. The catecholamine release-inhibitory peptide catestatin (chromogranin A344-363) modulates myocardial function in fish. J Exp Biol. 2010 Nov 01; 213(Pt 21):3636-43. PMID: 20952611.
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    60. Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton BA, O'Connor DT. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cell Mol Neurobiol. 2010 Nov; 30(8):1395-400. PMID: 21061160; PMCID: PMC3008929.
    61. Mahata SK, Mahata M, Fung MM, O'Connor DT. Reprint of: Catestatin: a multifunctional peptide from chromogranin A. Regul Pept. 2010 Nov 30; 165(1):52-62. PMID: 20965217.
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    62. Theurl M, Schgoer W, Albrecht K, Jeschke J, Egger M, Beer AG, Vasiljevic D, Rong S, Wolf AM, Bahlmann FH, Patsch JR, Wolf D, Schratzberger P, Mahata SK, Kirchmair R. The neuropeptide catestatin acts as a novel angiogenic cytokine via a basic fibroblast growth factor-dependent mechanism. Circ Res. 2010 Nov 26; 107(11):1326-35. PMID: 20930149.
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    63. Chen Y, Salem RM, Rao F, Fung MM, Bhatnagar V, Pandey B, Mahata M, Waalen J, Nievergelt CM, Lipkowitz MS, Hamilton BA, Mahata SK, O'Connor DT. Common charge-shift mutation Glu65Lys in K+ channel ß1-Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease. Am J Nephrol. 2010; 32(5):414-24. PMID: 20861615; PMCID: PMC2975731.
    64. Fung MM, Rao F, Poddar S, Mahata M, Khandrika S, Mahata SK, O'Connor DT. Early inflammatory and metabolic changes in association with AGTR1 polymorphisms in prehypertensive subjects. Am J Hypertens. 2011 Feb; 24(2):225-33. PMID: 20864943; PMCID: PMC3101264.
    65. Chen Y, Zhang K, Wen G, Rao F, Sanchez AP, Wang L, Rodriguez-Flores JL, Mahata M, Mahata SK, Waalen J, Ziegler MG, Hamilton BA, O'Connor DT. Human dopamine ß-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure. Am J Hypertens. 2011 Jan; 24(1):24-32. PMID: 20814407; PMCID: PMC4906639.
    66. Gayen JR, Zhang K, RamachandraRao SP, Mahata M, Chen Y, Kim HS, Naviaux RK, Sharma K, Mahata SK, O'Connor DT. Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene. Circ Cardiovasc Genet. 2010 Oct; 3(5):414-25. PMID: 20729505; PMCID: PMC3052689.
    67. Gu Y, Zhang K, Biswas N, Friese RS, Lin DH, Mahata SK, Hoshijima M, O'Connor DT, Peterson KL, Brar BK. Urocortin 2 lowers blood pressure and reduces plasma catecholamine levels in mice with hyperadrenergic activity. Endocrinology. 2010 Oct; 151(10):4820-9. PMID: 20668031; PMCID: PMC2946150.
    68. Brar BK, Helgeland E, Mahata SK, Zhang K, O'Connor DT, Helle KB, Jonassen AK. Human catestatin peptides differentially regulate infarct size in the ischemic-reperfused rat heart. Regul Pept. 2010 Nov 30; 165(1):63-70. PMID: 20655339; PMCID: PMC2998543.
    69. Chen Y, Lipkowitz MS, Salem RM, Fung MM, Bhatnagar V, Mahata M, Nievergelt CM, Rao F, Mahata SK, Schork NJ, Hicks PJ, Bowden DW, Freedman BI, Brophy VH, O'Connor DT. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. Am J Nephrol. 2010; 32(1):23-30. PMID: 20484896; PMCID: PMC2914391.
    70. Radek KA, Elias PM, Taupenot L, Mahata SK, O'Connor DT, Gallo RL. Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production. Cell Host Microbe. 2010 Apr 22; 7(4):277-89. PMID: 20413096; PMCID: PMC2916230.
    71. Dev NB, Gayen JR, O'Connor DT, Mahata SK. Chromogranin a and the autonomic system: decomposition of heart rate variability and rescue by its catestatin fragment. Endocrinology. 2010 Jun; 151(6):2760-8. PMID: 20410203; PMCID: PMC2875835.
    72. Zhang K, Rao F, Wang L, Rana BK, Ghosh S, Mahata M, Salem RM, Rodriguez-Flores JL, Fung MM, Waalen J, Tayo B, Taupenot L, Mahata SK, O'Connor DT. Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension. J Am Coll Cardiol. 2010 Apr 06; 55(14):1463-75. PMID: 20359597; PMCID: PMC2889490.
    73. Vaingankar SM, Li Y, Biswas N, Gayen J, Choksi S, Rao F, Ziegler MG, Mahata SK, O'Connor DT. Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses. J Hypertens. 2010 Apr; 28(4):817-25. PMID: 20139771; PMCID: PMC2947860.
    74. Rodríguez-Flores JL, Zhang K, Kang SW, Wen G, Ghosh S, Friese RS, Mahata SK, Subramaniam S, Hamilton BA, O'Connor DT. Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach. Mamm Genome. 2010 Apr; 21(3-4):195-204. PMID: 20204374; PMCID: PMC2844968.
    75. Stadinski BD, Delong T, Reisdorph N, Reisdorph R, Powell RL, Armstrong M, Piganelli JD, Barbour G, Bradley B, Crawford F, Marrack P, Mahata SK, Kappler JW, Haskins K. Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol. 2010 Mar; 11(3):225-31. PMID: 20139986; PMCID: PMC3166626.
    76. Mahata SK, Mahata M, Fung MM, O'Connor DT. Catestatin: a multifunctional peptide from chromogranin A. Regul Pept. 2010 Jun 08; 162(1-3):33-43. PMID: 20116404; PMCID: PMC2866790.
    77. Alam A, O'Connor DT, Perianayagam MC, Kolyada AY, Chen Y, Rao F, Mahata M, Mahata S, Liangos O, Jaber BL. Phenylethanolamine N-methyltransferase gene polymorphisms and adverse outcomes in acute kidney injury. Nephron Clin Pract. 2010; 114(4):c253-9. PMID: 20090367; PMCID: PMC2865401.
    78. Courel M, Soler-Jover A, Rodriguez-Flores JL, Mahata SK, Elias S, Montero-Hadjadje M, Anouar Y, Giuly RJ, O'Connor DT, Taupenot L. Pro-hormone secretogranin II regulates dense core secretory granule biogenesis in catecholaminergic cells. J Biol Chem. 2010 Mar 26; 285(13):10030-43. PMID: 20061385; PMCID: PMC2843166.
    79. Fung MM, Salem RM, Mehtani P, Thomas B, Lu CF, Perez B, Rao F, Stridsberg M, Ziegler MG, Mahata SK, O'Connor DT. Direct vasoactive effects of the chromogranin A (CHGA) peptide catestatin in humans in vivo. Clin Exp Hypertens. 2010; 32(5):278-87. PMID: 20662728; PMCID: PMC3109075.
    80. Chen Y, Wen G, Rao F, Zhang K, Wang L, Rodriguez-Flores JL, Sanchez AP, Mahata M, Taupenot L, Sun P, Mahata SK, Tayo B, Schork NJ, Ziegler MG, Hamilton BA, O'Connor DT. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure. J Hypertens. 2010 Jan; 28(1):76-86. PMID: 20009769; PMCID: PMC2860271.
    81. Vaingankar SM, Li Y, Corti A, Biswas N, Gayen J, O'Connor DT, Mahata SK. Long human CHGA flanking chromosome 14 sequence required for optimal BAC transgenic "rescue" of disease phenotypes in the mouse Chga knockout. Physiol Genomics. 2010 Mar 03; 41(1):91-101. PMID: 20009010; PMCID: PMC2841496.
    82. Friese RS, Gayen JR, Mahapatra NR, Schmid-Schönbein GW, O'Connor DT, Mahata SK. Global metabolic consequences of the chromogranin A-null model of hypertension: transcriptomic detection, pathway identification, and experimental verification. Physiol Genomics. 2010 Feb 04; 40(3):195-207. PMID: 19952279; PMCID: PMC2825767.
    83. Shih PB, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT. Peptide YY (PYY) Gene Polymorphisms in the 3'-Untranslated Region and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo. Endocr Rev. 2009 Dec 01; 30(7):934. PMID: 28199513.
      View in: PubMed
    84. Gayen JR, Gu Y, O'Connor DT, Mahata SK. Global disturbances in autonomic function yield cardiovascular instability and hypertension in the chromogranin a null mouse. Endocrinology. 2009 Nov; 150(11):5027-35. PMID: 19819970; PMCID: PMC2775982.
    85. Shih PA, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT. Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo. J Clin Endocrinol Metab. 2009 Nov; 94(11):4557-66. PMID: 19820027; PMCID: PMC2775651.
    86. Fung MM, Chen Y, Lipkowitz MS, Salem RM, Bhatnagar V, Mahata M, Nievergelt CM, Rao F, Mahata SK, Schork NJ, Brophy VH, O'Connor DT. Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. Nephrol Dial Transplant. 2009 Dec; 24(12):3677-86. PMID: 19745105; PMCID: PMC2790952.
    87. Wang L, Rao F, Zhang K, Mahata M, Rodriguez-Flores JL, Fung MM, Waalen J, Cockburn MG, Hamilton BA, Mahata SK, O'Connor DT. Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo. J Am Coll Cardiol. 2009 Sep 01; 54(10):944-54. PMID: 19712806; PMCID: PMC2792636.
    88. Gayen JR, Saberi M, Schenk S, Biswas N, Vaingankar SM, Cheung WW, Najjar SM, O'Connor DT, Bandyopadhyay G, Mahata SK. A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem. 2009 Oct 16; 284(42):28498-509. PMID: 19706599; PMCID: PMC2781393.
    89. Rana BK, Wessel J, Mahboubi V, Rao F, Haeller J, Gayen JR, Eskin E, Valle AM, Das M, Mahata SK, Taupenot L, Stridsberg M, Talley TT, Ziegler MG, Smith DW, Schork NJ, O'Connor DT, Taylor P. Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs. J Pharmacol Exp Ther. 2009 Nov; 331(2):419-28. PMID: 19671882; PMCID: PMC2775266.
    90. Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung MM, Zhang K, Stridsberg M, Ziegler MG, Hamilton BA, Lipkowitz MS, Taupenot L, Nievergelt C, Mahata SK, O'Connor DT. Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis. J Am Soc Nephrol. 2009 Jul; 20(7):1623-32. PMID: 19520754; PMCID: PMC2709688.
    91. Biswas N, Rodriguez-Flores JL, Courel M, Gayen JR, Vaingankar SM, Mahata M, Torpey JW, Taupenot L, O'Connor DT, Mahata SK. Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides. Endocrinology. 2009 Aug; 150(8):3547-57. PMID: 19372204; PMCID: PMC2717865.
    92. Zhang K, Rao F, Rana BK, Gayen JR, Calegari F, King A, Rosa P, Huttner WB, Stridsberg M, Mahata M, Vaingankar S, Mahboubi V, Salem RM, Rodriguez-Flores JL, Fung MM, Smith DW, Schork NJ, Ziegler MG, Taupenot L, Mahata SK, O'Connor DT. Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B. Circ Cardiovasc Genet. 2009 Feb; 2(1):46-56. PMID: 20011129.
      View in: PubMed
    93. Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT. Adrenergic polymorphism and the human stress response. Ann N Y Acad Sci. 2008 Dec; 1148:282-96. PMID: 19120120; PMCID: PMC2743085.
    94. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. PMID: 19033658; PMCID: PMC2575833.
    95. Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT. Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. J Am Coll Cardiol. 2008 Oct 28; 52(18):1468-81. PMID: 19017515; PMCID: PMC2659417.
    96. Egger M, Beer AG, Theurl M, Schgoer W, Hotter B, Tatarczyk T, Vasiljevic D, Frauscher S, Marksteiner J, Patsch JR, Schratzberger P, Djanani AM, Mahata SK, Kirchmair R. Monocyte migration: a novel effect and signaling pathways of catestatin. Eur J Pharmacol. 2008 Nov 19; 598(1-3):104-11. PMID: 18834877.
      View in: PubMed
    97. O'Connor DT, Zhu G, Rao F, Taupenot L, Fung MM, Das M, Mahata SK, Mahata M, Wang L, Zhang K, Greenwood TA, Shih PA, Cockburn MG, Ziegler MG, Stridsberg M, Martin NG, Whitfield JB. Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure. Circulation. 2008 Jul 15; 118(3):247-57. PMID: 18591442; PMCID: PMC2654229.
    98. Mahapatra NR, Taupenot L, Courel M, Mahata SK, O'Connor DT. The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. Biochemistry. 2008 Jul 08; 47(27):7167-78. PMID: 18549247; PMCID: PMC2576284.
    99. Angelone T, Quintieri AM, Brar BK, Limchaiyawat PT, Tota B, Mahata SK, Cerra MC. The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism. Endocrinology. 2008 Oct; 149(10):4780-93. PMID: 18535098; PMCID: PMC2582908.
    100. Vallon V, Eraly SA, Wikoff WR, Rieg T, Kaler G, Truong DM, Ahn SY, Mahapatra NR, Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, Nigam SK. Organic anion transporter 3 contributes to the regulation of blood pressure. J Am Soc Nephrol. 2008 Sep; 19(9):1732-40. PMID: 18508962; PMCID: PMC2518443.
    101. Mazza R, Gattuso A, Mannarino C, Brar BK, Barbieri SF, Tota B, Mahata SK. Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart. Am J Physiol Heart Circ Physiol. 2008 Jul; 295(1):H113-22. PMID: 18469147; PMCID: PMC2494752.
    102. Montesinos MS, Machado JD, Camacho M, Diaz J, Morales YG, Alvarez de la Rosa D, Carmona E, Castañeyra A, Viveros OH, O'Connor DT, Mahata SK, Borges R. The crucial role of chromogranins in storage and exocytosis revealed using chromaffin cells from chromogranin A null mouse. J Neurosci. 2008 Mar 26; 28(13):3350-8. PMID: 18367602.
      View in: PubMed
    103. Willis M, Prokesch M, Hutter-Paier B, Windisch M, Stridsberg M, Mahata SK, Kirchmair R, Wietzorrek G, Knaus HG, Jellinger K, Humpel C, Marksteiner J. Chromogranin B and Secretogranin II in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations and in Alzheimer patients. J Alzheimers Dis. 2008 Mar; 13(2):123-35. PMID: 18376054.
      View in: PubMed
    104. Courel M, Vasquez MS, Hook VY, Mahata SK, Taupenot L. Sorting of the neuroendocrine secretory protein Secretogranin II into the regulated secretory pathway: role of N- and C-terminal alpha-helical domains. J Biol Chem. 2008 Apr 25; 283(17):11807-22. PMID: 18299326; PMCID: PMC2431052.
    105. Salem RM, Cadman PE, Chen Y, Rao F, Wen G, Hamilton BA, Rana BK, Smith DW, Stridsberg M, Ward HJ, Mahata M, Mahata SK, Bowden DW, Hicks PJ, Freedman BI, Schork NJ, O'Connor DT. Chromogranin A polymorphisms are associated with hypertensive renal disease. J Am Soc Nephrol. 2008 Mar; 19(3):600-14. PMID: 18235090; PMCID: PMC2391050.
    106. Radek KA, Lopez-Garcia B, Hupe M, Niesman IR, Elias PM, Taupenot L, Mahata SK, O'Connor DT, Gallo RL. The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury. J Invest Dermatol. 2008 Jun; 128(6):1525-34. PMID: 18185531; PMCID: PMC2757066.
    107. Fung MM, Nguyen C, Mehtani P, Salem RM, Perez B, Thomas B, Das M, Schork NJ, Mahata SK, Ziegler MG, O'Connor DT. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. Circulation. 2008 Jan 29; 117(4):517-25. PMID: 18180394; PMCID: PMC2628716.
    108. Biswas N, Vaingankar SM, Mahata M, Das M, Gayen JR, Taupenot L, Torpey JW, O'Connor DT, Mahata SK. Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin. Endocrinology. 2008 Feb; 149(2):749-57. PMID: 17991725; PMCID: PMC2219303.
    109. Zhang L, Rao F, Zhang K, Khandrika S, Das M, Vaingankar SM, Bao X, Rana BK, Smith DW, Wessel J, Salem RM, Rodriguez-Flores JL, Mahata SK, Schork NJ, Ziegler MG, O'Connor DT. Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk. J Clin Invest. 2007 Sep; 117(9):2658-71. PMID: 17717598; PMCID: PMC1950457.
    110. Mosley CA, Taupenot L, Biswas N, Taulane JP, Olson NH, Vaingankar SM, Wen G, Schork NJ, Ziegler MG, Mahata SK, O'Connor DT. Biogenesis of the secretory granule: chromogranin A coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation. Biochemistry. 2007 Sep 25; 46(38):10999-1012. PMID: 17718510.
      View in: PubMed
    111. Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT. Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo. Circulation. 2007 Aug 28; 116(9):993-1006. PMID: 17698732.
      View in: PubMed
    112. Wen G, Wessel J, Zhou W, Ehret GB, Rao F, Stridsberg M, Mahata SK, Gent PM, Das M, Cooper RS, Chakravarti A, Zhou H, Schork NJ, O'connor DT, Hamilton BA. An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension. Hum Mol Genet. 2007 Jul 15; 16(14):1752-64. PMID: 17584765; PMCID: PMC2695823.
    113. Lillie EO, Mahata M, Khandrika S, Rao F, Bundey RA, Wen G, Chen Y, Taupenot L, Smith DW, Mahata SK, Ziegler MG, Cockburn M, Schork NJ, O'Connor DT. Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function. Circulation. 2007 May 01; 115(17):2282-91. PMID: 17438153.
      View in: PubMed
    114. Rao F, Wen G, Gayen JR, Das M, Vaingankar SM, Rana BK, Mahata M, Kennedy BP, Salem RM, Stridsberg M, Abel K, Smith DW, Eskin E, Schork NJ, Hamilton BA, Ziegler MG, Mahata SK, O'Connor DT. Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension. Circulation. 2007 May 01; 115(17):2271-81. PMID: 17438154.
      View in: PubMed
    115. O'Connor DT, Mahata SK, Mahata M, Jiang Q, Hook VY, Taupenot L. Primary culture of bovine chromaffin cells. Nat Protoc. 2007; 2(5):1248-53. PMID: 17546020; PMCID: PMC2715561.
    116. Zhang K, Rao F, Wen G, Salem RM, Vaingankar S, Mahata M, Mahapatra NR, Lillie EO, Cadman PE, Friese RS, Hamilton BA, Hook VY, Mahata SK, Taupenot L, O'Connor DT. Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin. Diabetes Obes Metab. 2006 Nov; 8(6):621-33. PMID: 17026486.
      View in: PubMed
    117. Mahapatra NR, Mahata M, Ghosh S, Gayen JR, O'Connor DT, Mahata SK. Molecular basis of neuroendocrine cell type-specific expression of the chromogranin B gene: Crucial role of the transcription factors CREB, AP-2, Egr-1 and Sp1. J Neurochem. 2006 Oct; 99(1):119-33. PMID: 16987240.
      View in: PubMed
    118. Mahapatra NR, Mahata M, Mahata SK, O'Connor DT. The chromogranin A fragment catestatin: specificity, potency and mechanism to inhibit exocytotic secretion of multiple catecholamine storage vesicle co-transmitters. J Hypertens. 2006 May; 24(5):895-904. PMID: 16612252.
      View in: PubMed
    119. Greenwood TA, Rao F, Stridsberg M, Mahapatra NR, Mahata M, Lillie EO, Mahata SK, Taupenot L, Schork NJ, O'Connor DT. Pleiotropic effects of novel trans-acting loci influencing human sympathochromaffin secretion. Physiol Genomics. 2006 May 16; 25(3):470-9. PMID: 16554546.
      View in: PubMed
    120. Nothacker HP, Wang Z, Zeng H, Mahata SK, O'Connor DT, Civelli O. Proadrenomedullin N-terminal peptide and cortistatin activation of MrgX2 receptor is based on a common structural motif. Eur J Pharmacol. 2005 Sep 05; 519(1-2):191-3. PMID: 16111673.
      View in: PubMed
    121. Mahapatra NR, O'Connor DT, Vaingankar SM, Hikim AP, Mahata M, Ray S, Staite E, Wu H, Gu Y, Dalton N, Kennedy BP, Ziegler MG, Ross J, Mahata SK. Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest. 2005 Jul; 115(7):1942-52. PMID: 16007257; PMCID: PMC1159140.
    122. O'Connor DT, Cadman PE, Smiley C, Salem RM, Rao F, Smith J, Funk SD, Mahata SK, Mahata M, Wen G, Taupenot L, Gonzalez-Yanes C, Harper KL, Henry RR, Sanchez-Margalet V. Pancreastatin: multiple actions on human intermediary metabolism in vivo, variation in disease, and naturally occurring functional genetic polymorphism. J Clin Endocrinol Metab. 2005 Sep; 90(9):5414-25. PMID: 15956083.
      View in: PubMed
    123. Friese RS, Mahboubi P, Mahapatra NR, Mahata SK, Schork NJ, Schmid-Schönbein GW, O'Connor DT. Common genetic mechanisms of blood pressure elevation in two independent rodent models of human essential hypertension. Am J Hypertens. 2005 May; 18(5 Pt 1):633-52. PMID: 15882546.
      View in: PubMed
    124. Mahapatra NR, Mahata M, Hazra PP, McDonough PM, O'Connor DT, Mahata SK. A dynamic pool of calcium in catecholamine storage vesicles. Exploration in living cells by a novel vesicle-targeted chromogranin A-aequorin chimeric photoprotein. J Biol Chem. 2004 Dec 03; 279(49):51107-21. PMID: 15358782.
      View in: PubMed
    125. Mahata SK, Mahata M, Wen G, Wong WB, Mahapatra NR, Hamilton BA, O'Connor DT. The catecholamine release-inhibitory "catestatin" fragment of chromogranin a: naturally occurring human variants with different potencies for multiple chromaffin cell nicotinic cholinergic responses. Mol Pharmacol. 2004 Nov; 66(5):1180-91. PMID: 15326220.
      View in: PubMed
    126. Fries RS, Mahboubi P, Mahapatra NR, Mahata SK, Schork NJ, Schmid-Schoenbein GW, O'Connor DT. Neuroendocrine transcriptome in genetic hypertension: multiple changes in diverse adrenal physiological systems. Hypertension. 2004 Jun; 43(6):1301-11. PMID: 15166183.
      View in: PubMed
    127. Preece NE, Nguyen M, Mahata M, Mahata SK, Mahapatra NR, Tsigelny I, O'Connor DT. Conformational preferences and activities of peptides from the catecholamine release-inhibitory (catestatin) region of chromogranin A. Regul Pept. 2004 Apr 15; 118(1-2):75-87. PMID: 14759560.
      View in: PubMed
    128. Wen G, Mahata SK, Cadman P, Mahata M, Ghosh S, Mahapatra NR, Rao F, Stridsberg M, Smith DW, Mahboubi P, Schork NJ, O'Connor DT, Hamilton BA. Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. Am J Hum Genet. 2004 Feb; 74(2):197-207. PMID: 14740315; PMCID: PMC1181918.
    129. Prommegger R, Ensinger C, Adlassnig C, Vaingankar S, Mahata SK, Marksteiner J, Margreiter R. Catestatin--a novel neuropeptide in carcinoid tumors of the appendix. Anticancer Res. 2004 Jan-Feb; 24(1):311-6. PMID: 15015613.
      View in: PubMed
    130. Lechner T, Adlassnig C, Humpel C, Kaufmann WA, Maier H, Reinstadler-Kramer K, Hinterhölzl J, Mahata SK, Jellinger KA, Marksteiner J. Chromogranin peptides in Alzheimer's disease. Exp Gerontol. 2004 Jan; 39(1):101-13. PMID: 14724070.
      View in: PubMed
    131. Wong C, Mahapatra NR, Chitbangonsyn S, Mahboubi P, Mahata M, Mahata SK, O'Connor DT. The angiotensin II receptor (Agtr1a): functional regulatory polymorphisms in a locus genetically linked to blood pressure variation in the mouse. Physiol Genomics. 2003 Jun 24; 14(1):83-93. PMID: 12697907.
      View in: PubMed
    132. Lee JC, Taylor CV, Gaucher SP, Toneff T, Taupenot L, Yasothornsrikul S, Mahata SK, Sei C, Parmer RJ, Neveu JM, Lane WS, Gibson BW, O'Connor DT, Hook VY. Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells. Biochemistry. 2003 Jun 17; 42(23):6938-46. PMID: 12795588.
      View in: PubMed
    133. Krüger PG, Mahata SK, Helle KB. Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides. Regul Pept. 2003 Jun 15; 114(1):29-35. PMID: 12763637.
      View in: PubMed
    134. Mahata SK, Mahapatra NR, Mahata M, Wang TC, Kennedy BP, Ziegler MG, O'Connor DT. Catecholamine secretory vesicle stimulus-transcription coupling in vivo. Demonstration by a novel transgenic promoter/photoprotein reporter and inhibition of secretion and transcription by the chromogranin A fragment catestatin. J Biol Chem. 2003 Aug 22; 278(34):32058-67. PMID: 12799369.
      View in: PubMed
    135. Mahapatra NR, Mahata M, O'Connor DT, Mahata SK. Secretin activation of chromogranin A gene transcription. Identification of the signaling pathways in cis and in trans. J Biol Chem. 2003 May 30; 278(22):19986-94. PMID: 12646581.
      View in: PubMed
    136. Taupenot L, Harper KL, Mahapatra NR, Parmer RJ, Mahata SK, O'Connor DT. Identification of a novel sorting determinant for the regulated pathway in the secretory protein chromogranin A. J Cell Sci. 2002 Dec 15; 115(Pt 24):4827-41. PMID: 12432071.
      View in: PubMed
    137. Bao X, Kennedy B, Enns R, Mahata M, Mahata S, O'Connor D, Ziegler MG. A truncated mouse phenylethanolamine N-methyltransferase splice variant with dominant-negative activity. Ann N Y Acad Sci. 2002 Oct; 971:89-91. PMID: 12438096.
      View in: PubMed
    138. Laslop A, Mahata SK. Neuropeptides and chromogranins: session overview. Ann N Y Acad Sci. 2002 Oct; 971:294-9. PMID: 12438139.
      View in: PubMed
    139. Cadman PE, Rao F, Mahata SK, O'Connor DT. Studies of the dysglycemic peptide, pancreastatin, using a human forearm model. Ann N Y Acad Sci. 2002 Oct; 971:528-9. PMID: 12438174.
      View in: PubMed
    140. Mahata SK, Mahapatra NR, Mahata M, O'Connor DT. Neuroendocrine cell type-specific and inducible expression of chromogranin/secretogranin genes: crucial promoter motifs. Ann N Y Acad Sci. 2002 Oct; 971:27-38. PMID: 12438085.
      View in: PubMed
    141. Mahata M, Mahapatra NR, O'Connor DT, Mahata SK. Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells. Mol Pharmacol. 2002 Jun; 61(6):1340-7. PMID: 12021395.
      View in: PubMed
    142. Herrero CJ, Alés E, Pintado AJ, López MG, García-Palomero E, Mahata SK, O'Connor DT, García AG, Montiel C. Modulatory mechanism of the endogenous peptide catestatin on neuronal nicotinic acetylcholine receptors and exocytosis. J Neurosci. 2002 Jan 15; 22(2):377-88. PMID: 11784782.
      View in: PubMed
    143. Mahata SK, Mahata M, Wakade AR, O'Connor DT. Primary structure and function of the catecholamine release inhibitory peptide catestatin (chromogranin A(344-364)): identification of amino acid residues crucial for activity. Mol Endocrinol. 2000 Oct; 14(10):1525-35. PMID: 11043569.
      View in: PubMed
    144. Mahata SK, Mahata M, Livsey CV, Gerdes HH, Huttner WB, O'Connor DT. Neuroendocrine cell type-specific and inducible expression of the secretogranin II gene: crucial role of cyclic adenosine monophosphate and serum response elements. Endocrinology. 1999 Feb; 140(2):739-49. PMID: 9927301.
      View in: PubMed
    145. Mahata SK, Mahata M, Parmer RJ, O'Connor DT. Desensitization of catecholamine release. The novel catecholamine release-inhibitory peptide catestatin (chromogranin a344-364) acts at the receptor to prevent nicotinic cholinergic tolerance. J Biol Chem. 1999 Jan 29; 274(5):2920-8. PMID: 9915830.
      View in: PubMed