David Roth

Title(s)Recall Hcomp, Anesthesiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Exosomes in aging and operative hypothermic circulatory arrest
    NIH R21AG058174Sep 1, 2018 - Jun 30, 2021
    Role: Principal Investigator
    Interdisciplinary Anesthesiology Research Training Program
    NIH T32GM121318Jul 1, 2017 - Jun 30, 2022
    Role: Co-Principal Investigator
    ShEEP Request for Vevo 3100 Imaging System
    NIH IS1BX003575May 1, 2016 - Sep 30, 2016
    Role: Principal Investigator
    Integrins and Caveolin Proteins in Cardiac Hypertrophy and Failure
    NIH R01HL115933Sep 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Protection of the Aged Myocardium
    NIH R01HL107200Jun 15, 2011 - Apr 30, 2016
    Role: Principal Investigator
    Enhancing Cardiac Protection
    NIH I01BX000783Oct 1, 2010 - Sep 30, 2019
    Role: Principal Investigator
    Caveolae and Anesthetic Induced Cardiac Protection
    NIH R01HL081400Apr 16, 2007 - Mar 31, 2012
    Role: Principal Investigator
    Discovery and Development of Therapeutic Genes for CHF
    NIH P01HL066941Sep 29, 2000 - Jun 30, 2020
    Role: Co-Investigator
    MYOCARDIAL ADAPTATION TO CORONARY OCCLUSION
    NIH R29HL040649Apr 1, 1988 - Mar 31, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Extracellular Vesicles: A New Paradigm for Cellular Communication in Perioperative Medicine, Critical Care, and Pain Management. Anesth Analg. 2021 Jul 22. Zhou YK, Patel HH, Roth DM. PMID: 34304233.
      View in: PubMed   Mentions:    Fields:    
    2. Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin). Hypertension. 2021 May 05; 77(5):1670-1682. Ying W, Tang K, Avolio E, Schilling JM, Pasqua T, Liu MA, Cheng H, Gao H, Zhang J, Mahata S, Ko MS, Bandyopadhyay G, Das S, Roth DM, Sahoo D, Webster NJG, Sheikh F, Ghosh G, Patel HH, Ghosh P, van den Bogaart G, Mahata SK. PMID: 33826401.
      View in: PubMed   Mentions: 2     Fields:    
    3. Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:434-450. Wang S, Leem JS, Podvin S, Hook V, Kleschevnikov N, Savchenko P, Dhanani M, Zhou K, Kelly IC, Zhang T, Miyanohara A, Nguyen P, Kleschevnikov A, Wagner SL, Trojanowski JQ, Roth DM, Patel HH, Patel PM, Head BP. PMID: 33981778.
      View in: PubMed   Mentions:
    4. Morphine induces physiological, structural, and molecular benefits in the diabetic myocardium. FASEB J. 2021 03; 35(3):e21407. Zemljic-Harpf AE, See Hoe LE, Schilling JM, Zuniga-Hertz JP, Nguyen A, Vaishnav YJ, Belza GJ, Budiono BP, Patel PM, Head BP, Dillmann WH, Mahata SK, Peart JN, Roth DM, Headrick JP, Patel HH. PMID: 33583084.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy. Am J Physiol Gastrointest Liver Physiol. 2020 03 01; 318(3):G531-G541. Kim SY, Kim KH, Schilling JM, Leem J, Dhanani M, Head BP, Roth DM, Zemljic-Harpf AE, Patel HH. PMID: 31961720.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Dexmedetomidine and Cardiac "Postconditioning": Clearing the Dex for Clinical Application. Anesth Analg. 2020 01; 130(1):87-89. Satomi S, Patel HH, Roth DM. PMID: 31842174.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. 1 + 1 = 4? Balanced anaesthesia: A sum that is greater than its parts. Br J Pharmacol. 2019 12; 176(24):4785-4786. Zhou Y, Roth DM, Patel HH. PMID: 31660583.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    8. Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs. Front Cell Neurosci. 2019; 13:324. Wang S, Zhang Z, Almenar-Queralt A, Leem J, DerMardirossian C, Roth DM, Patel PM, Patel HH, Head BP. PMID: 31379509.
      View in: PubMed   Mentions:
    9. Helium-Induced Changes in Circulating Caveolin in Mice Suggest a Novel Mechanism of Cardiac Protection. Int J Mol Sci. 2019 May 29; 20(11). Weber NC, Schilling JM, Warmbrunn MV, Dhanani M, Kerindongo R, Siamwala J, Song Y, Zemljic-Harpf AE, Fannon MJ, Hollmann MW, Preckel B, Roth DM, Patel HH. PMID: 31146391.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Efficacy and Safety of Belimumab and Azathioprine for Maintenance of Remission in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Study. Arthritis Rheumatol. 2019 06; 71(6):952-963. Jayne D, Blockmans D, Luqmani R, Moiseev S, Ji B, Green Y, Hall L, Roth D, Henderson RB, Merkel PA, BREVAS Study Collaborators . PMID: 30666823.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    11. Neuron-targeted caveolin-1 improves neuromuscular function and extends survival in SOD1G93A mice. FASEB J. 2019 06; 33(6):7545-7554. Sawada A, Wang S, Jian M, Leem J, Wackerbarth J, Egawa J, Schilling JM, Platoshyn O, Zemljic-Harpf A, Roth DM, Patel HH, Patel PM, Marsala M, Head BP. PMID: 30894019.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Cardiac-specific overexpression of caveolin-3 preserves t-tubular ICa during heart failure in mice. Exp Physiol. 2019 05; 104(5):654-666. Kong CHT, Bryant SM, Watson JJ, Roth DM, Patel HH, Cannell MB, James AF, Orchard CH. PMID: 30786093.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Metabolomic analysis of serum and myocardium in compensated heart failure after myocardial infarction. Life Sci. 2019 Mar 15; 221:212-223. McKirnan MD, Ichikawa Y, Zhang Z, Zemljic-Harpf AE, Fan S, Barupal DK, Patel HH, Hammond HK, Roth DM. PMID: 30731143.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    14. Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity. Cereb Cortex. 2018 09 01; 28(9):3255-3266. Egawa J, Zemljic-Harpf A, Mandyam CD, Niesman IR, Lysenko LV, Kleschevnikov AM, Roth DM, Patel HH, Patel PM, Head BP. PMID: 28981594.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    15. Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes. FASEB J. 2019 01; 33(1):1209-1225. Godoy JC, Niesman IR, Busija AR, Kassan A, Schilling JM, Schwarz A, Alvarez EA, Dalton ND, Drummond JC, Roth DM, Kararigas G, Patel HH, Zemljic-Harpf AE. PMID: 30169110.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. Caveolin-3 KO disrupts t-tubule structure and decreases t-tubular ICa density in mouse ventricular myocytes. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1101-H1111. Bryant SM, Kong CHT, Watson JJ, Gadeberg HC, Roth DM, Patel HH, Cannell MB, James AF, Orchard CH. PMID: 30028203.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. The Effects of Aging on the Regulation of T-Tubular ICa by Caveolin in Mouse Ventricular Myocytes. J Gerontol A Biol Sci Med Sci. 2018 05 09; 73(6):711-719. Kong CHT, Bryant SM, Watson JJ, Gadeberg HC, Roth DM, Patel HH, Cannell MB, Orchard CH, James AF. PMID: 29236992.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. No pain, no gain: balancing central versus peripheral benefits of analgesics in the age of the opioid crisis. Br J Pharmacol. 2018 03; 175(5):855-856. Patel HH, Roth DM. PMID: 29243218.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    19. Waterborne disease outbreaks associated with environmental and undetermined exposures to water - United States, 2013-2014. Am J Transplant. 2018 01; 18(1):262-267. McClung RP, Roth DM, Vigar M, Roberts VA, Kahler AM, Cooley LA, Hilborn ED, Wade TJ, Fullerton KE, Yoder JS, Hill VR. PMID: 29267998.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    20. Clinical trials: Treatment of HCV-infected patients with advanced kidney disease. Nat Rev Nephrol. 2018 01; 14(1):6-8. Ladino M, Roth D. PMID: 29176656.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Waterborne Disease Outbreaks Associated With Environmental and Undetermined Exposures to Water - United States, 2013-2014. MMWR Morb Mortal Wkly Rep. 2017 Nov 10; 66(44):1222-1225. McClung RP, Roth DM, Vigar M, Roberts VA, Kahler AM, Cooley LA, Hilborn ED, Wade TJ, Fullerton KE, Yoder JS, Hill VR. PMID: 29120997.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    22. Surveillance for Waterborne Disease Outbreaks Associated with Drinking Water - United States, 2013-2014. MMWR Morb Mortal Wkly Rep. 2017 Nov 10; 66(44):1216-1221. Benedict KM, Reses H, Vigar M, Roth DM, Roberts VA, Mattioli M, Cooley LA, Hilborn ED, Wade TJ, Fullerton KE, Yoder JS, Hill VR. PMID: 29121003.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansPHPublic Health
    23. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS One. 2017; 12(5):e0177660. Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross RS, Hammond HK, Patel HH, Roth DM. PMID: 28498861.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    24. Transplantation of kidneys from hepatitis C-positive donors into hepatitis C virus-infected recipients followed by early initiation of direct acting antiviral therapy: a single-center retrospective study. Transpl Int. 2017 Sep; 30(9):865-873. Bhamidimarri KR, Ladino M, Pedraza F, Guerra G, Mattiazzi A, Chen L, Ciancio G, Kupin W, Martin P, Burke G, Roth D. PMID: 28332729.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    25. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J. 2017 08; 31(8):3403-3411. Egawa J, Schilling JM, Cui W, Posadas E, Sawada A, Alas B, Zemljic-Harpf AE, Fannon-Pavlich MJ, Mandyam CD, Roth DM, Patel HH, Patel PM, Head BP. PMID: 28450301.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia. J Neurophysiol. 2017 01 01; 117(1):436-444. Kassan A, Egawa J, Zhang Z, Almenar-Queralt A, Nguyen QM, Lajevardi Y, Kim K, Posadas E, Jeste DV, Roth DM, Patel PM, Patel HH, Head BP. PMID: 27832597.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    27. Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion. . 2016 Dec 01; 311(6):C854-C865. Kassan A, Pham U, Nguyen Q, Reichelt ME, Cho E, Patel PM, Roth DM, Head BP, Patel HH. PMID: 27707689.
      View in: PubMed   Mentions:
    28. Chronic β1-adrenoceptor blockade impairs ischaemic tolerance and preconditioning in murine myocardium. Eur J Pharmacol. 2016 Oct 15; 789:1-7. See Hoe LE, Schilling JM, Busija AR, Haushalter KJ, Ozberk V, Keshwani MM, Roth DM, Toit ED, Headrick JP, Patel HH, Peart JN. PMID: 27373851.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    29. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Res Cardiol. 2016 May; 111(3):28. Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH, Roth DM. PMID: 27023865.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. Neuron-Targeted Caveolin-1 Improves Molecular Signaling, Plasticity, and Behavior Dependent on the Hippocampus in Adult and Aged Mice. Biol Psychiatry. 2017 01 15; 81(2):101-110. Mandyam CD, Schilling JM, Cui W, Egawa J, Niesman IR, Kellerhals SE, Staples MC, Busija AR, Risbrough VB, Posadas E, Grogman GC, Chang JW, Roth DM, Patel PM, Patel HH, Head BP. PMID: 26592463.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    31. Epigenetics: The Epicenter for Future Anesthesia Research? Anesthesiology. 2015 Oct; 123(4):743-4. Stary CM, Patel HH, Roth DM. PMID: 26259141.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    32. Caveolin-3 Overexpression Attenuates Cardiac Hypertrophy via Inhibition of T-type Ca2+ Current Modulated by Protein Kinase Cα in Cardiomyocytes. J Biol Chem. 2015 Sep 04; 290(36):22085-100. Markandeya YS, Phelan LJ, Woon MT, Keefe AM, Reynolds CR, August BK, Hacker TA, Roth DM, Patel HH, Balijepalli RC. PMID: 26170457.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    33. Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria. Cardiovasc Res. 2015 May 01; 106(2):227-36. Sun J, Nguyen T, Aponte AM, Menazza S, Kohr MJ, Roth DM, Patel HH, Murphy E, Steenbergen C. PMID: 25694588.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    34. Caveolins in cardioprotection - translatability and mechanisms. Br J Pharmacol. 2015 Apr; 172(8):2114-25. Schilling JM, Roth DM, Patel HH. PMID: 25377989.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    35. Role of caveolin-3 in lymphocyte activation. Life Sci. 2015 Jan 15; 121:35-9. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Tran C, Stary CM, Schilling JM, Bentley B, Patel HH, Roth DM. PMID: 25476831; PMCID: PMC4410709.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    36. Caveolin modulates integrin function and mechanical activation in the cardiomyocyte. FASEB J. 2015 Feb; 29(2):374-84. Israeli-Rosenberg S, Chen C, Li R, Deussen DN, Niesman IR, Okada H, Patel HH, Roth DM, Ross RS. PMID: 25366344.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    37. Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent. Anesthesiology. 2014 Sep; 121(3):538-48. Wang J, Schilling JM, Niesman IR, Headrick JP, Finley JC, Kwan E, Patel PM, Head BP, Roth DM, Yue Y, Patel HH. PMID: 24821070.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    38. Sarcolemmal cholesterol and caveolin-3 dependence of cardiac function, ischemic tolerance, and opioidergic cardioprotection. . 2014 Sep 15; 307(6):H895-903. See Hoe LE, Schilling JM, Tarbit E, Kiessling CJ, Busija AR, Niesman IR, Du Toit E, Ashton KJ, Roth DM, Headrick JP, Patel HH, Peart JN. PMID: 25063791.
      View in: PubMed   Mentions:
    39. Regulation of intracellular signaling and function by caveolin. FASEB J. 2014 Sep; 28(9):3823-31. Fridolfsson HN, Roth DM, Insel PA, Patel HH. PMID: 24858278.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    40. Plasma vasopressin levels in patients with right-sided heart dysfunction and chronic thromboembolic pulmonary hypertension (CTEPH). J Cardiothorac Vasc Anesth. 2014 Jun; 28(3):601-7. Nguyen L, Banks D, Manecke G, Shurter J, Schilling JM, Patel HH, Madani MM, Roth DM. PMID: 24746335.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry. Behav Brain Res. 2014 Jul 01; 267:6-11. Schilling JM, Cui W, Godoy JC, Risbrough VB, Niesman IR, Roth DM, Patel PM, Drummond JC, Patel HH, Zemljic-Harpf AE, Head BP. PMID: 24657594.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    42. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation. 2014 Mar 03; 11:39. Niesman IR, Schilling JM, Shapiro LA, Kellerhals SE, Bonds JA, Kleschevnikov AM, Cui W, Voong A, Krajewski S, Ali SS, Roth DM, Patel HH, Patel PM, Head BP. PMID: 24593993.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    43. Signaling epicenters: the role of caveolae and caveolins in volatile anesthetic induced cardiac protection. Curr Pharm Des. 2014; 20(36):5681-9. Horikawa YT, Tsutsumi YM, Patel HH, Roth DM. PMID: 24502576.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    44. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. PMID: 24091324.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    45. Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice. Hum Gene Ther. 2013 Sep; 24(9):777-85. Gao MH, Lai NC, Miyanohara A, Schilling JM, Suarez J, Tang T, Guo T, Tang R, Parikh J, Giamouridis D, Dillmann WH, Patel HH, Roth DM, Dalton ND, Hammond HK. PMID: 23931341.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    46. Caveolin isoform switching as a molecular, structural, and metabolic regulator of microglia. Mol Cell Neurosci. 2013 Sep; 56:283-97. Niesman IR, Zemke N, Fridolfsson HN, Haushalter KJ, Levy K, Grove A, Schnoor R, Finley JC, Patel PM, Roth DM, Head BP, Patel HH. PMID: 23851187.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    47. Epicatechin regulation of mitochondrial structure and function is opioid receptor dependent. Mol Nutr Food Res. 2013 Jun; 57(6):1007-14. Panneerselvam M, Ali SS, Finley JC, Kellerhals SE, Migita MY, Head BP, Patel PM, Roth DM, Patel HH. PMID: 23625721.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    48. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E387-96. Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, Blumenthal DK, Ali SS, Roth DM, Patel HH, Taylor SS. PMID: 23319652.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    49. Caveolins: targeting pro-survival signaling in the heart and brain. Front Physiol. 2012; 3:393. Stary CM, Tsutsumi YM, Patel PM, Head BP, Patel HH, Roth DM. PMID: 23060817.
      View in: PubMed   Mentions:
    50. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012 Nov; 26(11):4637-49. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH. PMID: 22859372.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    51. Comparison of adeno-associated virus serotypes and delivery methods for cardiac gene transfer. Hum Gene Ther Methods. 2012 Aug; 23(4):234-41. Fang H, Lai NC, Gao MH, Miyanohara A, Roth DM, Tang T, Hammond HK. PMID: 22966786.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    52. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology. 2012 Feb; 116(2):352-61. Pearn ML, Hu Y, Niesman IR, Patel HH, Drummond JC, Roth DM, Akassoglou K, Patel PM, Head BP. PMID: 22198221.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    53. Caveolins and heart diseases. Adv Exp Med Biol. 2012; 729:145-56. Panneerselvam M, Patel HH, Roth DM. PMID: 22411319.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    54. Volatile anesthetics protect cancer cells against tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via caveolins. Anesthesiology. 2011 Sep; 115(3):499-508. Kawaraguchi Y, Horikawa YT, Murphy AN, Murray F, Miyanohara A, Ali SS, Head BP, Patel PM, Roth DM, Patel HH. PMID: 21862885.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    55. Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy. Chest. 2012 Jan; 141(1):27-35. Kerr KM, Auger WR, Marsh JJ, Devendra G, Spragg RG, Kim NH, Channick RN, Jamieson SW, Madani MM, Manecke GR, Roth DM, Shragg GP, Fedullo PF. PMID: 21835900.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    56. From local to global: lipid emulsion (intralipid) makes a move. Anesthesiology. 2011 Aug; 115(2):226-8. Kawaraguchi Y, Roth DM, Patel HH. PMID: 21654493.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    57. Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. J Biol Chem. 2011 Sep 23; 286(38):33310-21. Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth DM, Patel HH, Patel PM. PMID: 21799010.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    58. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. J Am Coll Cardiol. 2011 May 31; 57(22):2273-83. Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel PA, Patel HH, Roth DM. PMID: 21616289.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    59. Role of decoy molecules in neuronal ischemic preconditioning. Life Sci. 2011 Apr 11; 88(15-16):670-4. Panneerselvam M, Patel PM, Roth DM, Kidd MW, Chin-Lee B, Head BP, Niesman IR, Inoue S, Patel HH, Davis DP. PMID: 21315738.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    60. Role of caveolae in cardiac protection. Pediatr Cardiol. 2011 Mar; 32(3):329-33. Roth DM, Patel HH. PMID: 21210089.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    61. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One. 2010 Dec 23; 5(12):e15697. Head BP, Peart JN, Panneerselvam M, Yokoyama T, Pearn ML, Niesman IR, Bonds JA, Schilling JM, Miyanohara A, Headrick J, Ali SS, Roth DM, Patel PM, Patel HH. PMID: 21203469.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    62. Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation. . 2010 Nov; 299(5):H1604-9. Panneerselvam M, Tsutsumi YM, Bonds JA, Horikawa YT, Saldana M, Dalton ND, Head BP, Patel PM, Roth DM, Patel HH. PMID: 20833967.
      View in: PubMed   Mentions:
    63. Opioid-induced preconditioning is dependent on caveolin-3 expression. Anesth Analg. 2010 Nov; 111(5):1117-21. Tsutsumi YM, Kawaraguchi Y, Niesman IR, Patel HH, Roth DM. PMID: 20736437.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    64. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem. 2010 Sep 03; 285(36):27632-40. Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth DM. PMID: 20581396.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    65. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection. Anesthesiology. 2010 May; 112(5):1136-45. Tsutsumi YM, Kawaraguchi Y, Horikawa YT, Niesman IR, Kidd MW, Chin-Lee B, Head BP, Patel PM, Roth DM, Patel HH. PMID: 20418694.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    66. Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice. J Am Coll Cardiol. 2010 Apr 06; 55(14):1476-86. Tang T, Lai NC, Hammond HK, Roth DM, Yang Y, Guo T, Gao MH. PMID: 20359598.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    67. Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology. 2009 Apr; 110(4):813-25. Head BP, Patel HH, Niesman IR, Drummond JC, Roth DM, Patel PM. PMID: 19293698.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    68. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation. 2008 Nov 04; 118(19):1979-88. Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. PMID: 18936328.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    69. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proc Natl Acad Sci U S A. 2008 Apr 29; 105(17):6386-91. Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. PMID: 18434542.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    70. Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice. J Am Coll Cardiol. 2008 Apr 15; 51(15):1490-7. Lai NC, Tang T, Gao MH, Saito M, Takahashi T, Roth DM, Hammond HK. PMID: 18402905.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    71. Mito-controversies: mitochondrial permeability transition pore and myocardial reperfusion injury. Anesthesiology. 2008 Feb; 108(2):182-4. Patel HH, Tsutsumi YM, Roth DM. PMID: 18212560.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    72. Effect of dexmedetomidine on cerebral blood flow velocity, cerebral metabolic rate, and carbon dioxide response in normal humans. Anesthesiology. 2008 Feb; 108(2):225-32. Drummond JC, Dao AV, Roth DM, Cheng CR, Atwater BI, Minokadeh A, Pasco LC, Patel PM. PMID: 18212567.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    73. Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 2008 Jan 01; 117(1):61-9. Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth DM, Hammond HK. PMID: 18071070.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    74. Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. J Mol Cell Cardiol. 2008 Jan; 44(1):123-30. Horikawa YT, Patel HH, Tsutsumi YM, Jennings MM, Kidd MW, Hagiwara Y, Ishikawa Y, Insel PA, Roth DM. PMID: 18054955.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    75. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. FASEB J. 2008 Mar; 22(3):828-40. Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth DM, Drummond JC, Patel PM. PMID: 17905724.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    76. Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction. . 2007 Nov; 293(5):H3216-20. Swaney JS, Patel HH, Yokoyama U, Lai NC, Spellman M, Insel PA, Roth DM. PMID: 17873016.
      View in: PubMed   Mentions:
    77. Reactive oxygen species trigger ischemic and pharmacological postconditioning: in vivo and in vitro characterization. Life Sci. 2007 Sep 22; 81(15):1223-7. Tsutsumi YM, Yokoyama T, Horikawa Y, Roth DM, Patel HH. PMID: 17915258.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    78. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. FASEB J. 2007 May; 21(7):1565-74. Patel HH, Tsutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel PA, Roth DM. PMID: 17272740.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    79. Adenylylcyclase gene transfer increases function of the failing heart. Hum Gene Ther. 2006 Oct; 17(10):1043-8. Rebolledo B, Lai NC, Gao MH, Takahashi T, Roth DM, Baird SM, Hammond HK. PMID: 17007567.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    80. Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction. Circulation. 2006 Aug 01; 114(5):388-96. Takahashi T, Tang T, Lai NC, Roth DM, Rebolledo B, Saito M, Lew WY, Clopton P, Hammond HK. PMID: 16864723.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    81. Cardiac-directed expression of adenylyl cyclase VI facilitates atrioventricular nodal conduction. J Am Coll Cardiol. 2006 Aug 01; 48(3):559-65. Sastry A, Arnold E, Gurji H, Iwasa A, Bui H, Hassankhani A, Patel HH, Feramisco JR, Roth DM, Lai NC, Hammond HK, Narayan SM. PMID: 16875984.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    82. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem. 2006 Sep 08; 281(36):26391-9. Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel PA. PMID: 16818493.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    83. Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy. J Mol Cell Cardiol. 2006 Jul; 41(1):170-81. Timofeyev V, He Y, Tuteja D, Zhang Q, Roth DM, Hammond HK, Chiamvimonvat N. PMID: 16750219.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    84. Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice. . 2006 Aug; 291(2):H979-83. Tsutsumi YM, Patel HH, Huang D, Roth DM. PMID: 16648187.
      View in: PubMed   Mentions:
    85. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. J Biol Chem. 2006 Jun 23; 281(25):17173-17179. Swaney JS, Patel HH, Yokoyama U, Head BP, Roth DM, Insel PA. PMID: 16618703.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    86. Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice. Anesthesiology. 2006 Mar; 104(3):495-502. Tsutsumi YM, Patel HH, Lai NC, Takahashi T, Head BP, Roth DM. PMID: 16508397.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    87. Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. . 2006 Jul; 291(1):H344-50. Patel HH, Head BP, Petersen HN, Niesman IR, Huang D, Gross GJ, Insel PA, Roth DM. PMID: 16501018.
      View in: PubMed   Mentions:
    88. Intracoronary delivery of an adenovirus encoding fibroblast growth factor-4 in myocardial ischemia: effect of serum antibodies and previous exposure to adenovirus. Hum Gene Ther. 2006 Feb; 17(2):230-8. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Roth DA, McKirnan MD, Canestrelli I, Gao MH, Dalton N, Lai NC, Roth DM, Hammond HK. PMID: 16454656.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    89. Adenylyl cyclase type V deletion increases basal left ventricular function and reduces left ventricular contractile responsiveness to beta-adrenergic stimulation. Basic Res Cardiol. 2006 Mar; 101(2):117-26. Tang T, Lai NC, Roth DM, Drumm J, Guo T, Lee KW, Han PL, Dalton N, Gao MH. PMID: 16283593.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    90. A randomized trial of three renal transplant induction antibodies: early comparison of tacrolimus, mycophenolate mofetil, and steroid dosing, and newer immune-monitoring. Transplantation. 2005 Aug 27; 80(4):457-65. Ciancio G, Burke GW, Gaynor JJ, Carreno MR, Cirocco RE, Mathew JM, Mattiazzi A, Cordovilla T, Roth D, Kupin W, Rosen A, Esquenazi V, Tzakis AG, Miller J. PMID: 16123718.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCellsCTClinical Trials
    91. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J Biol Chem. 2005 Sep 02; 280(35):31036-44. Head BP, Patel HH, Roth DM, Lai NC, Niesman IR, Farquhar MG, Insel PA. PMID: 15961389.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    92. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Ann N Y Acad Sci. 2005 Jun; 1047:166-72. Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. PMID: 16093494.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    93. Myocardial gene transfer and long-term expression following intracoronary delivery of adeno-associated virus. J Gene Med. 2005 Mar; 7(3):316-24. Kaspar BK, Roth DM, Lai NC, Drumm JD, Erickson DA, McKirnan MD, Hammond HK. PMID: 15515115.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    94. Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):437-42. Swaney JS, Roth DM, Olson ER, Naugle JE, Meszaros JG, Insel PA. PMID: 15625103.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    95. Nitroprusside increases gene transfer associated with intracoronary delivery of adenovirus. Hum Gene Ther. 2004 Oct; 15(10):989-94. Roth DM, Lai NC, Gao MH, Fine S, McKirnan MD, Roth DA, Hammond HK. PMID: 15585114.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    96. Natriuretic peptide gene expression after beta-adrenergic stimulation in adult mouse cardiac myocytes. DNA Cell Biol. 2004 Sep; 23(9):586-91. Ander AN, Duggirala SK, Drumm JD, Roth DM. PMID: 15383178.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    97. Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure. Circulation. 2004 Jul 20; 110(3):330-6. Lai NC, Roth DM, Gao MH, Tang T, Dalton N, Lai YY, Spellman M, Clopton P, Hammond HK. PMID: 15249510.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    98. Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy. . 2004 Nov; 287(5):H1906-12. Tang T, Gao MH, Roth DM, Guo T, Hammond HK. PMID: 15242835.
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    99. Increased regional function and perfusion after intracoronary delivery of adenovirus encoding fibroblast growth factor 4: report of preclinical data. Hum Gene Ther. 2004 Jun; 15(6):574-87. Gao MH, Lai NC, McKirnan MD, Roth DA, Rubanyi GM, Dalton N, Roth DM, Hammond HK. PMID: 15212716.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    100. Deep hypothermic circulatory arrest and the femoral-to-radial arterial pressure gradient. J Cardiothorac Vasc Anesth. 2004 Apr; 18(2):175-9. Manecke GR, Parimucha M, Stratmann G, Wilson WC, Roth DM, Auger WR, Kerr KM, Jamieson SW, Kapelanski DP, Mitchell MM. PMID: 15073707.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    101. Indirect intracoronary delivery of adenovirus encoding adenylyl cyclase increases left ventricular contractile function in mice. . 2004 Jul; 287(1):H172-7. Roth DM, Lai NC, Gao MH, Drumm JD, Jimenez J, Feramisco JR, Hammond HK. PMID: 15001445.
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    102. Cardiac-directed expression of adenylyl cyclase and heart rate regulation. Basic Res Cardiol. 2003 Nov; 98(6):380-7. Roth DM, Drumm JD, Bhargava V, Swaney JS, Gao MH, Hammond HK. PMID: 14556083.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    103. Controlled expression of cardiac-directed adenylylcyclase type VI provides increased contractile function. Cardiovasc Res. 2002 Nov; 56(2):197-204. Gao MH, Bayat H, Roth DM, Yao Zhou J, Drumm J, Burhan J, Hammond HK. PMID: 12393090.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    104. Impact of anesthesia on cardiac function during echocardiography in mice. . 2002 Jun; 282(6):H2134-40. Roth DM, Swaney JS, Dalton ND, Gilpin EA, Ross J. PMID: 12003821.
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    105. Progressive heart failure after myocardial infarction in mice. Basic Res Cardiol. 2002 May; 97(3):206-13. Bayat H, Swaney JS, Ander AN, Dalton N, Kennedy BP, Hammond HK, Roth DM. PMID: 12061390.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    106. Adenylyl cyclase increases survival in cardiomyopathy. Circulation. 2002 Apr 23; 105(16):1989-94. Roth DM, Bayat H, Drumm JD, Gao MH, Swaney JS, Ander A, Hammond HK. PMID: 11997288.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    107. An epidemiologic study of early renal replacement therapy after orthotopic liver transplantation. J Am Soc Nephrol. 2002 Jan; 13(1):228-233. Contreras G, Garces G, Quartin AA, Cely C, LaGatta MA, Barreto GA, Roth D, Gomez E. PMID: 11752042.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
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