Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    David Roth

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentAnesthesiology
    Address9500 Gilman Drive #9125
    CA La Jolla 92093
    Phone858-552-8585
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Interdisciplinary Anesthesiology Research Training Program
      NIH/NIGMS T32GM121318Jul 1, 2017 - Jun 30, 2022
      Role: Co-Principal Investigator
      ShEEP Request for Vevo 3100 Imaging System
      VA IS1BX003575May 1, 2016 - Sep 30, 2016
      Role: Principal Investigator
      Integrins and Caveolin Proteins in Cardiac Hypertrophy and Failure
      NIH/NHLBI R01HL115933Sep 1, 2013 - May 31, 2017
      Role: Principal Investigator
      Protection of the Aged Myocardium
      NIH/NHLBI R01HL107200Jun 15, 2011 - Apr 30, 2015
      Role: Principal Investigator
      Enhancing Cardiac Protection
      VA I01BX000783Oct 1, 2010 - Mar 31, 2019
      Role: Principal Investigator
      Caveolae and Anesthetic Induced Cardiac Protection
      NIH/NHLBI R01HL081400Apr 16, 2007 - Mar 31, 2012
      Role: Principal Investigator
      Discovery and Development of Therapeutic Genes for CHF
      NIH P01HL066941Sep 29, 2000 - Jun 30, 2018
      Role: Co-Investigator
      MYOCARDIAL ADAPTATION TO CORONARY OCCLUSION
      NIH/NHLBI R29HL040649Apr 1, 1988 - Mar 31, 1993
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross RS, Hammond HK, Patel HH, Roth D. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS One. 2017; 12(5):e0177660. PMID: 28498861.
        View in: PubMed
      2. Bhamidimarri KR, Ladino M, Pedraza F, Guerra G, Mattiazzi A, Chen L, Ciancio G, Kupin W, Martin P, Burke G, Roth D. Transplantation of kidneys from hepatitis C-positive donors into hepatitis C virus-infected recipients followed by early initiation of direct acting antiviral therapy: a single-center retrospective study. Transpl Int. 2017 Sep; 30(9):865-873. PMID: 28332729.
        View in: PubMed
      3. Kassan A, Egawa J, Zhang Z, Almenar-Queralt A, Nguyen QM, Lajevardi Y, Kim K, Posadas E, Jeste DV, Roth D, Patel PM, Patel HH, Head BP. Caveolin-1 Regulation of Disrupted-in-Schizophrenia-1 as a Potential Therapeutic Target for Schizophrenia. J Neurophysiol. 2016 Nov 2; jn.00481.2016. PMID: 27832597.
        View in: PubMed
      4. Kassan A, Pham U, Nguyen Q, Reichelt ME, Cho E, Patel PM, Roth D, Head BP, Patel HH. Caveolin-3 plays a critical role in autophagy after ischemia reperfusion. Am J Physiol Cell Physiol. 2016 Oct 5; ajpcell.00147.2016. PMID: 27707689.
        View in: PubMed
      5. See Hoe LE, Schilling JM, Busija AR, Haushalter KJ, Ozberk V, Keshwani MM, Roth D, Toit ED, Headrick JP, Patel HH, Peart JN. Chronic ß1-adrenoceptor blockade impairs ischaemic tolerance and preconditioning in murine myocardium. Eur J Pharmacol. 2016 Oct 15; 789:1-7. PMID: 27373851; NIHMSID: NIHMS803933 [Available on 10/15/17].
        View in: PubMed
      6. Ladino M, Pedraza F, Roth D. Hepatitis C Virus Infection in Chronic Kidney Disease. J Am Soc Nephrol. 2016 Aug; 27(8):2238-46. PMID: 27095799.
        View in: PubMed
      7. Suarez JF, Rosa R, Lorio MA, Morris MI, Abbo LM, Simkins J, Guerra G, Roth D, Kupin WL, Mattiazzi A, Ciancio G, Chen LJ, Burke GW, Goldstein MJ, Ruiz P, Camargo JF. Pretransplant CD4 Count Influences Immune Reconstitution and Risk of Infectious Complications in Human Immunodeficiency Virus-Infected Kidney Allograft Recipients. Am J Transplant. 2016 Aug; 16(8):2463-72. PMID: 26953224.
        View in: PubMed
      8. Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH, Roth D. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Res Cardiol. 2016 May; 111(3):28. PMID: 27023865.
        View in: PubMed
      9. Mandyam CD, Schilling JM, Cui W, Egawa J, Niesman IR, Kellerhals SE, Staples MC, Busija AR, Risbrough VB, Posadas E, Grogman GC, Chang JW, Roth D, Patel PM, Patel HH, Head BP. Neuron-Targeted Caveolin-1 Improves Molecular Signaling, Plasticity, and Behavior Dependent on the Hippocampus in Adult and Aged Mice. Biol Psychiatry. 2015 Oct 8. PMID: 26592463.
        View in: PubMed
      10. Stary CM, Patel HH, Roth D. Epigenetics: The Epicenter for Future Anesthesia Research? Anesthesiology. 2015 Oct; 123(4):743-4. PMID: 26259141.
        View in: PubMed
      11. Markandeya YS, Phelan LJ, Woon MT, Keefe AM, Reynolds CR, August BK, Hacker TA, Roth D, Patel HH, Balijepalli RC. Caveolin-3 Overexpression Attenuates Cardiac Hypertrophy via Inhibition of T-type Ca2+ Current Modulated by Protein Kinase Ca in Cardiomyocytes. J Biol Chem. 2015 Sep 4; 290(36):22085-100. PMID: 26170457.
        View in: PubMed
      12. Sun J, Nguyen T, Aponte AM, Menazza S, Kohr MJ, Roth D, Patel HH, Murphy E, Steenbergen C. Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria. Cardiovasc Res. 2015 May 1; 106(2):227-36. PMID: 25694588.
        View in: PubMed
      13. Schilling JM, Roth D, Patel HH. Caveolins in cardioprotection - translatability and mechanisms. Br J Pharmacol. 2015 Apr; 172(8):2114-25. PMID: 25377989.
        View in: PubMed
      14. Tran C, Stary CM, Schilling JM, Bentley B, Patel HH, Roth D. Role of caveolin-3 in lymphocyte activation. Life Sci. 2015 Jan 15; 121:35-9. PMID: 25476831.
        View in: PubMed
      15. Israeli-Rosenberg S, Chen C, Li R, Deussen DN, Niesman IR, Okada H, Patel HH, Roth D, Ross RS. Caveolin modulates integrin function and mechanical activation in the cardiomyocyte. FASEB J. 2015 Feb; 29(2):374-84. PMID: 25366344.
        View in: PubMed
      16. Pfeiffer ER, Wright AT, Edwards AG, Stowe JC, McNall K, Tan J, Niesman I, Patel HH, Roth D, Omens JH, McCulloch AD. Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing. J Mol Cell Cardiol. 2014 Nov; 76:265-74. PMID: 25257915.
        View in: PubMed
      17. Wang J, Schilling JM, Niesman IR, Headrick JP, Finley JC, Kwan E, Patel PM, Head BP, Roth D, Yue Y, Patel HH. Cardioprotective Trafficking of Caveolin to Mitochondria Is Gi-protein Dependent. Anesthesiology. 2014 Sep; 121(3):538-48. PMID: 24821070.
        View in: PubMed
      18. See Hoe LE, Schilling JM, Tarbit E, Kiessling CJ, Busija AR, Niesman IR, Du Toit E, Ashton KJ, Roth D, Headrick JP, Patel HH, Peart JN. Sarcolemmal cholesterol and caveolin-3 dependence of cardiac function, ischemic tolerance, and opioidergic cardioprotection. Am J Physiol Heart Circ Physiol. 2014 Sep 15; 307(6):H895-903. PMID: 25063791.
        View in: PubMed
      19. Fridolfsson HN, Roth D, Insel PA, Patel HH. Regulation of intracellular signaling and function by caveolin. FASEB J. 2014 Sep; 28(9):3823-31. PMID: 24858278.
        View in: PubMed
      20. Nguyen L, Banks D, Manecke G, Shurter J, Schilling JM, Patel HH, Madani MM, Roth D. Plasma Vasopressin Levels in Patients With Right-Sided Heart Dysfunction and Chronic Thromboembolic Pulmonary Hypertension (CTEPH). J Cardiothorac Vasc Anesth. 2014 Jun; 28(3):601-7. PMID: 24746335.
        View in: PubMed
      21. Schilling JM, Cui W, Godoy JC, Risbrough VB, Niesman IR, Roth D, Patel PM, Drummond JC, Patel HH, Zemljic-Harpf AE, Head BP. Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry. Behav Brain Res. 2014 Jul 1; 267:6-11. PMID: 24657594.
        View in: PubMed
      22. Niesman IR, Schilling JM, Shapiro LA, Kellerhals SE, Bonds JA, Kleschevnikov AM, Cui W, Voong A, Krajewski S, Ali SS, Roth D, Patel HH, Patel PM, Head BP. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation. 2014; 11(1):39. PMID: 24593993.
        View in: PubMed
      23. Horikawa YT, Tsutsumi YM, Patel HH, Roth D. Signaling epicenters: the role of caveolae and caveolins in volatile anesthetic induced cardiac protection. Curr Pharm Des. 2014; 20(36):5681-9. PMID: 24502576.
        View in: PubMed
      24. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth D, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct 1; 123(10):4294-308. PMID: 24091324.
        View in: PubMed
      25. Gao MH, Lai NC, Miyanohara A, Schilling JM, Suarez J, Tang T, Guo T, Tang R, Parikh J, Giamouridis D, Dillmann WH, Patel HH, Roth D, Dalton ND, Hammond HK. Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice. Hum Gene Ther. 2013 Sep; 24(9):777-85. PMID: 23931341.
        View in: PubMed
      26. Niesman IR, Zemke N, Fridolfsson HN, Haushalter KJ, Levy K, Grove A, Schnoor R, Finley JC, Patel PM, Roth D, Head BP, Patel HH. Caveolin isoform switching as a molecular, structural, and metabolic regulator of microglia. Mol Cell Neurosci. 2013 Sep; 56:283-97. PMID: 23851187.
        View in: PubMed
      27. Panneerselvam M, Ali SS, Finley JC, Kellerhals SE, Migita MY, Head BP, Patel PM, Roth D, Patel HH. Epicatechin regulation of mitochondrial structure and function is opioid receptor dependent. Mol Nutr Food Res. 2013 Jun; 57(6):1007-14. PMID: 23625721.
        View in: PubMed
      28. Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, Blumenthal DK, Ali SS, Roth D, Patel HH, Taylor SS. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E387-96. PMID: 23319652.
        View in: PubMed
      29. Stary CM, Tsutsumi YM, Patel PM, Head BP, Patel HH, Roth D. Caveolins: targeting pro-survival signaling in the heart and brain. Front Physiol. 2012; 3:393. PMID: 23060817.
        View in: PubMed
      30. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth D, Insel PA, Patel HH. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012 Nov; 26(11):4637-49. PMID: 22859372.
        View in: PubMed
      31. Fang H, Lai NC, Gao MH, Miyanohara A, Roth D, Tang T, Hammond HK. Comparison of adeno-associated virus serotypes and delivery methods for cardiac gene transfer. Hum Gene Ther Methods. 2012 Aug; 23(4):234-41. PMID: 22966786.
        View in: PubMed
      32. Pearn ML, Hu Y, Niesman IR, Patel HH, Drummond JC, Roth D, Akassoglou K, Patel PM, Head BP. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology. 2012 Feb; 116(2):352-61. PMID: 22198221.
        View in: PubMed
      33. Yamazaki KG, Ihm SH, Thomas RL, Roth D, Villarreal F. Cell adhesion molecule mediation of myocardial inflammatory responses associated with ventricular pacing. Am J Physiol Heart Circ Physiol. 2012 Apr 1; 302(7):H1387-93. PMID: 22268115.
        View in: PubMed
      34. Panneerselvam M, Patel HH, Roth D. Caveolins and heart diseases. Adv Exp Med Biol. 2012; 729:145-56. PMID: 22411319.
        View in: PubMed
      35. Kawaraguchi Y, Horikawa YT, Murphy AN, Murray F, Miyanohara A, Ali SS, Head BP, Patel PM, Roth D, Patel HH. Volatile anesthetics protect cancer cells against tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via caveolins. Anesthesiology. 2011 Sep; 115(3):499-508. PMID: 21862885.
        View in: PubMed
      36. Kerr KM, Auger WR, Marsh JJ, Devendra G, Spragg RG, Kim NH, Channick RN, Jamieson SW, Madani MM, Manecke GR, Roth D, Shragg GP, Fedullo PF. Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy. Chest. 2012 Jan; 141(1):27-35. PMID: 21835900.
        View in: PubMed
      37. Kawaraguchi Y, Roth D, Patel HH. From local to global: lipid emulsion (intralipid) makes a move. Anesthesiology. 2011 Aug; 115(2):226-8. PMID: 21654493.
        View in: PubMed
      38. Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth D, Patel HH, Patel PM. Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. J Biol Chem. 2011 Sep 23; 286(38):33310-21. PMID: 21799010.
        View in: PubMed
      39. Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel PA, Patel HH, Roth D. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. J Am Coll Cardiol. 2011 May 31; 57(22):2273-83. PMID: 21616289.
        View in: PubMed
      40. Panneerselvam M, Patel PM, Roth D, Kidd MW, Chin-Lee B, Head BP, Niesman IR, Inoue S, Patel HH, Davis DP. Role of decoy molecules in neuronal ischemic preconditioning. Life Sci. 2011 Apr 11; 88(15-16):670-4. PMID: 21315738.
        View in: PubMed
      41. Roth D, Patel HH. Role of caveolae in cardiac protection. Pediatr Cardiol. 2011 Mar; 32(3):329-33. PMID: 21210089.
        View in: PubMed
      42. Head BP, Peart JN, Panneerselvam M, Yokoyama T, Pearn ML, Niesman IR, Bonds JA, Schilling JM, Miyanohara A, Headrick J, Ali SS, Roth D, Patel PM, Patel HH. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One. 2010; 5(12):e15697. PMID: 21203469.
        View in: PubMed
      43. Panneerselvam M, Tsutsumi YM, Bonds JA, Horikawa YT, Saldana M, Dalton ND, Head BP, Patel PM, Roth D, Patel HH. Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1604-9. PMID: 20833967.
        View in: PubMed
      44. Tsutsumi YM, Kawaraguchi Y, Niesman IR, Patel HH, Roth D. Opioid-induced preconditioning is dependent on caveolin-3 expression. Anesth Analg. 2010 Nov; 111(5):1117-21. PMID: 20736437.
        View in: PubMed
      45. Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth D. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem. 2010 Sep 3; 285(36):27632-40. PMID: 20581396.
        View in: PubMed
      46. Tsutsumi YM, Kawaraguchi Y, Horikawa YT, Niesman IR, Kidd MW, Chin-Lee B, Head BP, Patel PM, Roth D, Patel HH. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection. Anesthesiology. 2010 May; 112(5):1136-45. PMID: 20418694.
        View in: PubMed
      47. Tang T, Lai NC, Hammond HK, Roth D, Yang Y, Guo T, Gao MH. Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice. J Am Coll Cardiol. 2010 Apr 6; 55(14):1476-86. PMID: 20359598.
        View in: PubMed
      48. Head BP, Patel HH, Niesman IR, Drummond JC, Roth D, Patel PM. Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology. 2009 Apr; 110(4):813-25. PMID: 19293698.
        View in: PubMed
      49. Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth D. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation. 2008 Nov 4; 118(19):1979-88. PMID: 18936328.
        View in: PubMed
      50. Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth D, Insel PA. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proc Natl Acad Sci U S A. 2008 Apr 29; 105(17):6386-91. PMID: 18434542.
        View in: PubMed
      51. Lai NC, Tang T, Gao MH, Saito M, Takahashi T, Roth D, Hammond HK. Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice. J Am Coll Cardiol. 2008 Apr 15; 51(15):1490-7. PMID: 18402905.
        View in: PubMed
      52. Patel HH, Tsutsumi YM, Roth D. Mito-controversies: mitochondrial permeability transition pore and myocardial reperfusion injury. Anesthesiology. 2008 Feb; 108(2):182-4. PMID: 18212560.
        View in: PubMed
      53. Drummond JC, Dao AV, Roth D, Cheng CR, Atwater BI, Minokadeh A, Pasco LC, Patel PM. Effect of dexmedetomidine on cerebral blood flow velocity, cerebral metabolic rate, and carbon dioxide response in normal humans. Anesthesiology. 2008 Feb; 108(2):225-32. PMID: 18212567.
        View in: PubMed
      54. Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth D, Hammond HK. Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 2008 Jan 1; 117(1):61-9. PMID: 18071070.
        View in: PubMed
      55. Horikawa YT, Patel HH, Tsutsumi YM, Jennings MM, Kidd MW, Hagiwara Y, Ishikawa Y, Insel PA, Roth D. Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury. J Mol Cell Cardiol. 2008 Jan; 44(1):123-30. PMID: 18054955.
        View in: PubMed
      56. Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth D, Drummond JC, Patel PM. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. FASEB J. 2008 Mar; 22(3):828-40. PMID: 17905724.
        View in: PubMed
      57. Swaney JS, Patel HH, Yokoyama U, Lai NC, Spellman M, Insel PA, Roth D. Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3216-20. PMID: 17873016.
        View in: PubMed
      58. Tsutsumi YM, Yokoyama T, Horikawa Y, Roth D, Patel HH. Reactive oxygen species trigger ischemic and pharmacological postconditioning: in vivo and in vitro characterization. Life Sci. 2007 Sep 22; 81(15):1223-7. PMID: 17915258.
        View in: PubMed
      59. Patel HH, Tsutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel PA, Roth D. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. FASEB J. 2007 May; 21(7):1565-74. PMID: 17272740.
        View in: PubMed
      60. Rebolledo B, Lai NC, Gao MH, Takahashi T, Roth D, Baird SM, Hammond HK. Adenylylcyclase gene transfer increases function of the failing heart. Hum Gene Ther. 2006 Oct; 17(10):1043-8. PMID: 17007567.
        View in: PubMed
      61. Takahashi T, Tang T, Lai NC, Roth D, Rebolledo B, Saito M, Lew WY, Clopton P, Hammond HK. Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction. Circulation. 2006 Aug 1; 114(5):388-96. PMID: 16864723.
        View in: PubMed
      62. Sastry A, Arnold E, Gurji H, Iwasa A, Bui H, Hassankhani A, Patel HH, Feramisco JR, Roth D, Lai NC, Hammond HK, Narayan SM. Cardiac-directed expression of adenylyl cyclase VI facilitates atrioventricular nodal conduction. J Am Coll Cardiol. 2006 Aug 1; 48(3):559-65. PMID: 16875984.
        View in: PubMed
      63. Head BP, Patel HH, Roth D, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel PA. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem. 2006 Sep 8; 281(36):26391-9. PMID: 16818493.
        View in: PubMed
      64. Timofeyev V, He Y, Tuteja D, Zhang Q, Roth D, Hammond HK, Chiamvimonvat N. Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy. J Mol Cell Cardiol. 2006 Jul; 41(1):170-81. PMID: 16750219.
        View in: PubMed
      65. Tsutsumi YM, Patel HH, Huang D, Roth D. Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H979-83. PMID: 16648187.
        View in: PubMed
      66. Swaney JS, Patel HH, Yokoyama U, Head BP, Roth D, Insel PA. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. J Biol Chem. 2006 Jun 23; 281(25):17173-9. PMID: 16618703.
        View in: PubMed
      67. Tsutsumi YM, Patel HH, Lai NC, Takahashi T, Head BP, Roth D. Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice. Anesthesiology. 2006 Mar; 104(3):495-502. PMID: 16508397.
        View in: PubMed
      68. Patel HH, Head BP, Petersen HN, Niesman IR, Huang D, Gross GJ, Insel PA, Roth D. Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H344-50. PMID: 16501018.
        View in: PubMed
      69. Roth DA, McKirnan MD, Canestrelli I, Gao MH, Dalton N, Lai NC, Roth D, Hammond HK. Intracoronary delivery of an adenovirus encoding fibroblast growth factor-4 in myocardial ischemia: effect of serum antibodies and previous exposure to adenovirus. Hum Gene Ther. 2006 Feb; 17(2):230-8. PMID: 16454656.
        View in: PubMed
      70. Tang T, Lai NC, Roth D, Drumm J, Guo T, Lee KW, Han PL, Dalton N, Gao MH. Adenylyl cyclase type V deletion increases basal left ventricular function and reduces left ventricular contractile responsiveness to beta-adrenergic stimulation. Basic Res Cardiol. 2006 Mar; 101(2):117-26. PMID: 16283593.
        View in: PubMed
      71. Insel PA, Head BP, Patel HH, Roth D, Bundey RA, Swaney JS. Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1131-4. PMID: 16246064.
        View in: PubMed
      72. Ciancio G, Burke GW, Gaynor JJ, Carreno MR, Cirocco RE, Mathew JM, Mattiazzi A, Cordovilla T, Roth D, Kupin W, Rosen A, Esquenazi V, Tzakis AG, Miller J. A randomized trial of three renal transplant induction antibodies: early comparison of tacrolimus, mycophenolate mofetil, and steroid dosing, and newer immune-monitoring. Transplantation. 2005 Aug 27; 80(4):457-65. PMID: 16123718.
        View in: PubMed
      73. Head BP, Patel HH, Roth D, Lai NC, Niesman IR, Farquhar MG, Insel PA. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J Biol Chem. 2005 Sep 2; 280(35):31036-44. PMID: 15961389.
        View in: PubMed
      74. Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth D. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Ann N Y Acad Sci. 2005 Jun; 1047:166-72. PMID: 16093494.
        View in: PubMed
      75. Kaspar BK, Roth D, Lai NC, Drumm JD, Erickson DA, McKirnan MD, Hammond HK. Myocardial gene transfer and long-term expression following intracoronary delivery of adeno-associated virus. J Gene Med. 2005 Mar; 7(3):316-24. PMID: 15515115.
        View in: PubMed
      76. Swaney JS, Roth D, Olson ER, Naugle JE, Meszaros JG, Insel PA. Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):437-42. PMID: 15625103.
        View in: PubMed
      77. Roth DM, Lai NC, Gao MH, Fine S, McKirnan MD, Roth D, Hammond HK. Nitroprusside increases gene transfer associated with intracoronary delivery of adenovirus. Hum Gene Ther. 2004 Oct; 15(10):989-94. PMID: 15585114.
        View in: PubMed
      78. Ander AN, Duggirala SK, Drumm JD, Roth D. Natriuretic peptide gene expression after beta-adrenergic stimulation in adult mouse cardiac myocytes. DNA Cell Biol. 2004 Sep; 23(9):586-91. PMID: 15383178.
        View in: PubMed
      79. Lai NC, Roth D, Gao MH, Tang T, Dalton N, Lai YY, Spellman M, Clopton P, Hammond HK. Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure. Circulation. 2004 Jul 20; 110(3):330-6. PMID: 15249510.
        View in: PubMed
      80. Tang T, Gao MH, Roth D, Guo T, Hammond HK. Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1906-12. PMID: 15242835.
        View in: PubMed
      81. Gao MH, Lai NC, McKirnan MD, Roth DA, Rubanyi GM, Dalton N, Roth D, Hammond HK. Increased regional function and perfusion after intracoronary delivery of adenovirus encoding fibroblast growth factor 4: report of preclinical data. Hum Gene Ther. 2004 Jun; 15(6):574-87. PMID: 15212716.
        View in: PubMed
      82. Manecke GR, Parimucha M, Stratmann G, Wilson WC, Roth D, Auger WR, Kerr KM, Jamieson SW, Kapelanski DP, Mitchell MM. Deep hypothermic circulatory arrest and the femoral-to-radial arterial pressure gradient. J Cardiothorac Vasc Anesth. 2004 Apr; 18(2):175-9. PMID: 15073707.
        View in: PubMed
      83. Roth D, Lai NC, Gao MH, Drumm JD, Jimenez J, Feramisco JR, Hammond HK. Indirect intracoronary delivery of adenovirus encoding adenylyl cyclase increases left ventricular contractile function in mice. Am J Physiol Heart Circ Physiol. 2004 Jul; 287(1):H172-7. PMID: 15001445.
        View in: PubMed
      84. Contreras G, Pardo V, Leclercq B, Lenz O, Tozman E, O'Nan P, Roth D. Sequential therapies for proliferative lupus nephritis. N Engl J Med. 2004 Mar 4; 350(10):971-80. PMID: 14999109.
        View in: PubMed
      85. Roth D, Drumm JD, Bhargava V, Swaney JS, Gao MH, Hammond HK. Cardiac-directed expression of adenylyl cyclase and heart rate regulation. Basic Res Cardiol. 2003 Nov; 98(6):380-7. PMID: 14556083.
        View in: PubMed
      86. Gao MH, Bayat H, Roth D, Yao Zhou J, Drumm J, Burhan J, Hammond HK. Controlled expression of cardiac-directed adenylylcyclase type VI provides increased contractile function. Cardiovasc Res. 2002 Nov; 56(2):197-204. PMID: 12393090.
        View in: PubMed
      87. Contreras G, Garces G, Reich J, Banerjee D, Young L, Cely C, Gadalean F, Perez G, Roth D. Predictors of alkalosis after liver transplantation. Am J Kidney Dis. 2002 Sep; 40(3):517-24. PMID: 12200803.
        View in: PubMed
      88. Roth D, Swaney JS, Dalton ND, Gilpin EA, Ross J. Impact of anesthesia on cardiac function during echocardiography in mice. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2134-40. PMID: 12003821.
        View in: PubMed
      89. Bayat H, Swaney JS, Ander AN, Dalton N, Kennedy BP, Hammond HK, Roth D. Progressive heart failure after myocardial infarction in mice. Basic Res Cardiol. 2002 May; 97(3):206-13. PMID: 12061390.
        View in: PubMed
      90. Roth D, Bayat H, Drumm JD, Gao MH, Swaney JS, Ander A, Hammond HK. Adenylyl cyclase increases survival in cardiomyopathy. Circulation. 2002 Apr 23; 105(16):1989-94. PMID: 11997288.
        View in: PubMed
      91. Peters AH, Drumm J, Ferrell C, Roth DA, Roth D, McCaman M, Novak PL, Friedman J, Engler R, Braun RE. Absence of germline infection in male mice following intraventricular injection of adenovirus. Mol Ther. 2001 Dec; 4(6):603-13. PMID: 11735345.
        View in: PubMed
      92. Carlson EB, Dalenberg C, Armstrong J, Daniels JW, Loewenstein R, Roth D. Multivariate prediction of posttraumatic symptoms in psychiatric inpatients. J Trauma Stress. 2001 Jul; 14(3):549-67. PMID: 11534885.
        View in: PubMed
      93. Ciancio G, Miller A, Burke GW, Gharagozloo H, Rosen A, Roth D, Kupin W, Pinna A, Cespedes M, Esquenazi V, Miller J. Daclizumab induction for primary kidney transplant recipients using tacrolimus, mycophenolate mofetil, and steroids as maintenance immunosuppression. Transplant Proc. 2001 Feb-Mar; 33(1-2):1013-4. PMID: 11267169.
        View in: PubMed
      94. Lai NC, Roth DM, Gao MH, Fine S, Head BP, Zhu J, McKirnan MD, Kwong C, Dalton N, Urasawa K, Roth D, Hammond HK. Intracoronary delivery of adenovirus encoding adenylyl cyclase VI increases left ventricular function and cAMP-generating capacity. Circulation. 2000 Nov 7; 102(19):2396-401. PMID: 11067795.
        View in: PubMed
      95. Roth D, Gao MH, Lai NC, Drumm J, Dalton N, Zhou JY, Zhu J, Entrikin D, Hammond HK. Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. Circulation. 1999 Jun 22; 99(24):3099-102. PMID: 10377071.
        View in: PubMed
      96. Gao MH, Lai NC, Roth D, Zhou J, Zhu J, Anzai T, Dalton N, Hammond HK. Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice. Circulation. 1999 Mar 30; 99(12):1618-22. PMID: 10096940.
        View in: PubMed
      97. Xenos EX, Ciancio G, Burke GW, Roth D, Miller J. The use of tacrolimus as induction and maintenance immunosuppression in renal cadaveric transplant recipients over the age of 60. Clin Transplant. 1997 Oct; 11(5 Pt 2):497-9. PMID: 9361949.
        View in: PubMed
      98. Goskowicz R, Harrell JH, Roth D. Intraoperative diagnosis of torsion of the left lung after repair of a disruption of the descending thoracic aorta. Anesthesiology. 1997 Jul; 87(1):164-6. PMID: 9232148.
        View in: PubMed
      99. Roth D, Benumof JL. Intubation through a laryngeal mask airway with a nasal RAE tube: stabilization of the proximal end of the tube. Anesthesiology. 1996 Nov; 85(5):1220. PMID: 8916855.
        View in: PubMed
      100. Roth D, Burgoyne RD. Stimulation of catecholamine secretion from adrenal chromaffin cells by 14-3-3 proteins is due to reorganisation of the cortical actin network. FEBS Lett. 1995 Oct 23; 374(1):77-81. PMID: 7589517.
        View in: PubMed
      101. Klahr S, Breyer JA, Beck GJ, Dennis VW, Hartman JA, Roth D, Steinman TI, Wang SR, Yamamoto ME. Dietary protein restriction, blood pressure control, and the progression of polycystic kidney disease. Modification of Diet in Renal Disease Study Group. J Am Soc Nephrol. 1995 Jun; 5(12):2037-47. PMID: 7579052.
        View in: PubMed
      102. Burgoyne RD, Morgan A, Roth D. Characterization of proteins that regulate calcium-dependent exocytosis in adrenal chromaffin cells. Ann N Y Acad Sci. 1994 Mar 9; 710:333-46. PMID: 8154759.
        View in: PubMed
      103. Carroll SM, White FC, Roth D, Bloor CM. Heparin accelerates coronary collateral development in a porcine model of coronary artery occlusion. Circulation. 1993 Jul; 88(1):198-207. PMID: 8319333.
        View in: PubMed
      104. Engler RL, Roth D, del Balzo U, Ito BR. Intracoronary C5a induces myocardial ischemia by mechanisms independent of the neutrophil: leukocyte filters desensitize the myocardium to C5a. FASEB J. 1991 Nov; 5(14):2983-91. PMID: 1661246.
        View in: PubMed
      105. Roth D, White FC, Nichols ML, Dobbs SL, Longhurst JC, Bloor CM. Effect of long-term exercise on regional myocardial function and coronary collateral development after gradual coronary artery occlusion in pigs. Circulation. 1990 Nov; 82(5):1778-89. PMID: 2225376.
        View in: PubMed
      106. Ito BR, Roth D, Engler RL. Thromboxane A2 and peptidoleukotrienes contribute to the myocardial ischemia and contractile dysfunction in response to intracoronary infusion of complement C5a in pigs. Circ Res. 1990 Mar; 66(3):596-607. PMID: 2137727.
        View in: PubMed
      107. Ito BR, Roth D, Chenoweth DE, Lefer AM, Engler RL. Thromboxane is produced in response to intracoronary infusions of complement C5a in pigs. Cyclooxygenase blockade does not reduce the myocardial ischemia and leukocyte accumulation. Circ Res. 1989 Nov; 65(5):1220-32. PMID: 2509096.
        View in: PubMed
      108. White FC, Roth D, Bloor CM. Coronary collateral reserve during exercise induced ischemia in swine. Basic Res Cardiol. 1989 Jan-Feb; 84(1):42-54. PMID: 2923605.
        View in: PubMed
      109. Roth D, White FC, Bloor CM. Altered minimal coronary resistance to antegrade reflow after chronic coronary artery occlusion in swine. Circ Res. 1988 Aug; 63(2):330-9. PMID: 3396154.
        View in: PubMed
      110. Martin SE, Chenoweth DE, Engler RL, Roth D, Longhurst JC. C5a decreases regional coronary blood flow and myocardial function in pigs: implications for a granulocyte mechanism. Circ Res. 1988 Aug; 63(2):483-91. PMID: 3396162.
        View in: PubMed
      111. Manyari DE, Knudtson M, Kloiber R, Roth D. Sequential thallium-201 myocardial perfusion studies after successful percutaneous transluminal coronary artery angioplasty: delayed resolution of exercise-induced scintigraphic abnormalities. Circulation. 1988 Jan; 77(1):86-95. PMID: 2961482.
        View in: PubMed
      112. Roth D, White FC, Mathieu-Costello O, Guth BD, Heusch G, Bloor CM, Longhurst JC. Effects of left circumflex Ameroid constrictor placement on adrenergic innervation of myocardium. Am J Physiol. 1987 Dec; 253(6 Pt 2):H1425-34. PMID: 3425744.
        View in: PubMed
      113. Roth D, Maruoka Y, Rogers J, White FC, Longhurst JC, Bloor CM. Development of coronary collateral circulation in left circumflex Ameroid-occluded swine myocardium. Am J Physiol. 1987 Nov; 253(5 Pt 2):H1279-88. PMID: 3318503.
        View in: PubMed
      114. Heusch G, Guth BD, Roth D, Seitelberger R, Ross J. Contractile responses to sympathetic activation after coronary instrumentation. Am J Physiol. 1987 Jun; 252(6 Pt 2):H1059-69. PMID: 3591962.
        View in: PubMed
      115. O'Konski MS, White FC, Longhurst J, Roth D, Bloor CM. Ameroid constriction of the proximal left circumflex coronary artery in swine. A model of limited coronary collateral circulation. Am J Cardiovasc Pathol. 1987 Jan; 1(1):69-77. PMID: 3455237.
        View in: PubMed
      116. White FC, Roth D, Bloor CM. The pig as a model for myocardial ischemia and exercise. Lab Anim Sci. 1986 Aug; 36(4):351-6. PMID: 3773444.
        View in: PubMed
      117. Lefer AM, Roth D, Kugler JL, Smith JB. Modulation of receptor mediated leukotriene release in the perfused heart. Gen Pharmacol. 1986; 17(4):437-40. PMID: 3019823.
        View in: PubMed
      118. Roth D, Lefer DJ, Hock CE, Lefer AM. Effects of peptide leukotrienes on cardiac dynamics in rat, cat, and guinea pig hearts. Am J Physiol. 1985 Sep; 249(3 Pt 2):H477-84. PMID: 4037097.
        View in: PubMed
      119. Smith JB, Roth D, Lefer AM, Petasis NA, Nicolaou KC. Modulation of leukotriene synthesis and actions by synthetic derivatives of arachidonic acid. Prostaglandins. 1985 May; 29(5):765-71. PMID: 4011927.
        View in: PubMed
      120. Roth D, Lefer AM. Leukotrienes in coronary angiopathy of diabetes. Prog Clin Biol Res. 1985; 199:115-25. PMID: 3934679.
        View in: PubMed
      121. Lefer AM, Roth D. Absence of direct inotropic effects of peptide leukotrienes in isolated mammalian heart preparations. Prog Clin Biol Res. 1985; 199:59-70. PMID: 4070317.
        View in: PubMed
      122. Lefer AM, Leprán I, Roth D, Smith JB. Specificity of anti-leukotriene actions of nicardipine. Pharmacol Res Commun. 1984 Dec; 16(12):1141-50. PMID: 6522440.
        View in: PubMed
      123. Roth D, Smith JB, Lefer AM. Leukotriene production in isolated tissues of diabetic rats. Prostaglandins Leukot Med. 1984 Oct; 16(1):29-37. PMID: 6440151.
        View in: PubMed
      124. Roth D, Foster KA, Lefer AM. Coronary vascular responsiveness to non-eicosanoid vasoconstrictors in the perfused diabetic rat heart. Res Commun Chem Pathol Pharmacol. 1984 Aug; 45(2):317-20. PMID: 6207576.
        View in: PubMed
      125. Lefer AM, Roth D, Lefer DJ, Smith JB. Potentiation of leukotriene formation in pulmonary and vascular tissue. Naunyn Schmiedebergs Arch Pharmacol. 1984 Jun; 326(2):186-9. PMID: 6089002.
        View in: PubMed
      126. Roth D, Reibel DK, Lefer AM. Altered coronary vascular responsiveness to leukotrienes in alloxan-diabetic rats. Circ Res. 1984 Apr; 54(4):388-95. PMID: 6325035.
        View in: PubMed
      127. Roth D, Feduska R, Lefer AM, Smith JB. Effects of lipoxygenase inhibitors in arachidonate-induced sudden death. J Pharm Pharmacol. 1984 Mar; 36(3):205-7. PMID: 6144761.
        View in: PubMed
      128. Reibel DK, Roth D, Lefer BL, Lefer AM. Hyperreactivity of coronary vasculature in platelet-perfused hearts from diabetic rats. Am J Physiol. 1983 Oct; 245(4):H640-5. PMID: 6414313.
        View in: PubMed
      129. Roth D, Lefer AM. Studies on the mechanism of leukotriene induced coronary artery constriction. Prostaglandins. 1983 Oct; 26(4):573-81. PMID: 6318273.
        View in: PubMed
      130. Roth D, Reibel DK, Lefer AM. Vascular responsiveness and eicosanoid production in diabetic rats. Diabetologia. 1983 May; 24(5):372-6. PMID: 6347785.
        View in: PubMed
      131. Burke SE, Roth D, Lefer AM. Antagonism of platelet aggregation by 13-azaprostanoic acid in acute myocardial ischemia and sudden death. Thromb Res. 1983 Mar 1; 29(5):473-88. PMID: 6857596.
        View in: PubMed
      132. Roth D, Burke SE, Lefer AM. Protective actions of ibuprofen in arachidonate-induced sudden death. Pharmacology. 1983; 27(3):169-75. PMID: 6413987.
        View in: PubMed
      133. Roth D, Lefer AM, Smith JB, Nicolaou KC. Anti-thromboxane A2 actions of pinane thromboxane A2 derivatives. Prostaglandins Leukot Med. 1982 Nov; 9(5):503-9. PMID: 6960376.
        View in: PubMed
      134. Lefer AM, Roth D. Actions of a protease inhibitor in arachidonate induced sudden death in rabbits. Pharmacol Res Commun. 1982 Feb; 14(2):121-30. PMID: 6175983.
        View in: PubMed
      135. Roth D, Kostuk WJ. Noninvasive and invasive demonstration of spontaneous regression of coronary artery disease. Circulation. 1980 Oct; 62(4):888-96. PMID: 7408161.
        View in: PubMed
      136. Roth D, Bayat H. The role of residual tumor in the chest wall in the late dissemination of mammary cancer. Ann Surg. 1968 Nov; 168(5):887-90. PMID: 5684192.
        View in: PubMed
      137. MCCONNELL KP, ROTH DM. PASSAGE OF SELENIUM ACROSS THE PLACENTA AND ALSO INTO THE MILK OF THE DOG. J Nutr. 1964 Dec; 84:340-4. PMID: 14242350.
        View in: PubMed
      David's Networks
      Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Similar People
      People who share similar concepts with this person.
      _
      Same Department
      Physical Neighbors
      People whose addresses are nearby this person.
      _