Huilin Zhou

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Gross chromosomal rearrangements (GCRs), including chromosomal translocations, inversions and other rearrangements, are a hallmark of human cancers. The goal of my laboratory is to study the specific signaling pathways, utilizing phosphorylation, sumoylation and ubiquitination that act to maintain genome integrity. We chose Saccharomyces cerevisiae as a model system due to its available genetic assays and because it allows facile biochemical and proteomic studies. Studies in my laboratory have focused on two areas: 1) the DNA damage checkpoint, and 2) protein sumoylation and ubiquitination in genome maintenance. A convergence of genetic, biochemical and proteomic approaches are being pursued to study the molecular mechanisms of signaling pathways that specifically prevent genome rearrangements.

    Research Focus Areas:

  • Biochemistry and Structural Biology

  • Cell Division and Cell Cycle Control

  • DNA Replication and Repair

  • Genetics and Genomics

  • Signal Transduction


    • Collapse Research 
    Collapse Research Activities and Funding
    Orbitrap Fusion Mass Spectrometer
    NIH S10OD023498Mar 15, 2017 - Mar 14, 2018
    Role: Principal Investigator
    Suppression of duplication-mediated genome rearrangements by protein sumoylation
    NIH R01GM116897Sep 30, 2015 - Mar 31, 2024
    Role: Principal Investigator
    Regulation and functions of DNA damage checkpoint kinases in Yeast
    NIH R01GM080469Apr 1, 2007 - Mar 31, 2014
    Role: Principal Investigator
    Technology for the Analysis of Protein Phosphorylation
    NIH K22HG002604Sep 30, 2002 - Aug 31, 2006
    Role: Principal Investigator

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    1. Quantitative phosphoproteomics: New technologies and applications in the DNA damage response. . 2010 Sep 01; 9(17):3479-84. Zhou H, Albuquerque CP, Liang J, Suhandynata RT, Weng S. PMID: 20855976.
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