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Robert Naviaux

Title(s)Professor In Residence, Medicine
SchoolHealth Sciences
Address214 Dickinson St., Bldg CTF, Rm C102, MC#8467
San Diego CA 92103
Phone619-543-2904
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    Collapse Biography 
    Collapse Awards and Honors
    Hailey’s Wish Foundation2008Hailey’s Hero Award, For Outstanding Research and Clinical Care of children with mitochondrial disea
    Thomson ESI2007Science Citation Index “Fast Moving Front Article”
    United Mitochondrial Disease Foundation Mitochondrial Medicine2007Best Abstract Award
    2002Honored in a non-fiction book entitled, Anna’s Friends—Lessons Learned from a Short and Beautiful Li

    Collapse Overview 
    Collapse Overview
    Research in my lab has focused on the role of mitochondria and metabolism in monogenic and complex disorders in children and adults. These disorders range from orphan diseases like Alpers and Leigh syndromes, to common diseases like autism, chronic fatigue syndrome (CFS), fibromyalgia, post-traumatic stress disorder (PTSD), depression, traumatic brain injury (TBI), chronic traumatic encephalopathy (CTE), cancer, diabetes, and autoimmune disorders, and acute and chronic infectious diseases like Lyme, malaria, and tuberculosis. We have a special interest in the molecular mechanisms of healing and tissue regeneration, innate immunity, and the interplay between genetic and environmental factors in human health and disease (Ecogenetics). My lab discovered the molecular basis of Alpers Syndrome—the oldest Mendelian form of mitochondrial disease—and we were the first to show that defects in a human DNA polymerase (the mitochondrial DNA polymerase ?, POLG) could cause human disease. We were the first to quantify the risk of neurodegeneration with infection in mitochondrial disease and the first to characterize the metabolic features of the cell danger response (CDR). My lab has developed a number of advanced technologies like biocavity laser spectroscopy, mtDNA mutation detection by mass spectrometry, and novel methods for exosome purification and analysis. We developed some of the first methods to isolate metagenomic DNA from beach sand and ocean core sediments for use in the molecular reconstruction of modern and ancient marine ecosystems. This has given us a unique window into the ecosystem biology and metabolic contributions of the gut microbiome to human health. We have developed new tools for deep phenotyping of health and disease by NextGen metabolomics and targeted mass spectrometry of samples from a wide array of biofluids, tissues, and cultured cells. These tools, along with state-of-the-art methods in mass spectrometry, stable isotope tracer studies for flux metabolomics, mitochondrial respiratory chain and polarographic analysis, permit us to dissect the metabolomic and molecular features of any disease in any cell type.

    Research in my lab has focused on the role of mitochondrial DNA replication, copy number regulation, DNA damage, and nucleotide signaling in development, aging, healing and regeneration. We also study the systems biology of monogenic and complex diseases like autism and diabetes. We were the first to quantify the risk of neurodegeneration with infection in mitochondrial disease. We were also the first to show that defects in a human DNA polymerase (the mitochondrial DNA polymerase ? POLG) could cause disease. Our lab has developed a number of advanced technologies like biocavity laser spectroscopy and mtDNA mutation detection by mass spectrometry to help with rapid and early diagnosis of mitochondrial disease. Recently, we have developed new bioinformatic methods to analyze mtDNA sequence data produced by NextGen sequencing platforms like Illumina. These tools, along with state-of-the-art methods in mitochondrial respiratory chain and polarographic analysis permit us to dissect the metabolic and molecular features of virtually any disease of interest. Immediate interests include the genesis and treatment of diabetes and autism, and mutation arrest therapies for cancer and viral disease, with special attention to the crossroads of innate immunity, inflammation, somatic cell genetics, and metabolism.

    Education
    - 2009-Present - Professor, Departments of Medicine, Pediatrics, and Pathology, University of California, San Diego, School of Medicine.
    - 2003-2009 Associate Professor, Departments of Medicine and Pediatrics, University of California, San Diego, School of Medicine.
    - 2003-2004 - Visiting Scholar (Biochemistry of the mito-chondrial DNA polymerase), National Institute of Environmental Health Sciences, Research
    - 2001-2003 - Assistant Professor, Department of Pediatrics, Biochemical Genetics and Metabolism,
    - 1997-2003 - Assistant Professor, Department of Medicine, Medical Genetics, Biochemical Genetics and Metabolism, University of California, San Diego, School of Medicine
    - 1994-1997 - Fellowship (Biochemical Genetics, mtDNA Replication), University of California, San Diego Medical Center, San Diego, CA
    - 1990-1994 - Postdoc (Retrovirology, Gene Therapy), The Salk Institute, La Jolla, CA
    - 1986, 1989 - M.D., Ph.D. (Genetics, Virology), Indiana University School of Medicine, Indianapolis, IN
    - 1981 - M.S. (Zoology), Indiana University, Bloomington, IN
    - 1979 - B.S. (Biological Sciences), University of California, Davis, CA
    - 1977-1978 - Undergraduate (Biochemistry), Georg August Universität, Göttingen, Germany

    Employment
    - 2009 - Present: Professor, Departments of Medicine, Pediatrics, and Pathology, University of California, San Diego, CA
    - 2003 - 2009: Associate Professor, Departments of Medicine and Pediatrics, University of California, San Diego, CA
    - 2001 - 2003: Assistant Professor, Department of Pediatrics, Biochemical Genetics and Metabolism, University of California, San Diego, CA
    - 1997 - 2003: Assistant Professor, Department of Medicine, Medical Genetics, Biochemical Genetics and Metabolism, University of California, San Diego, CA
    - 1986 - 1990: Intern and Resident, Internal Medicine, American Board of Internal Medicine (ABIM), Clinical Investigator Pathway, University of California, Davis
    - 1979 - 1981: X-ray Crystallographic Analysis, Beck Analytical Services, Bloomington, IN
    - 1978 - 1979: Undergraduate Research Assistant, Experimental Hematology, Radiobiology Laboratory, University of California, Davis
    - 1976: Undergraduate Research Intern, Tumor Immunology, National Institutes of Health, NCI, Bethesda, MD

    Collapse Research 
    Collapse Research Activities and Funding
    MITOCHONDRIA AND AUTISM 2010
    NIH/NINDS R13NS070555Jun 1, 2010 - May 31, 2011
    Role: Principal Investigator
    A MOUSE MODEL OF ALPERS SYNDROME
    NIH/NINDS R21NS051815Jul 17, 2006 - Jun 30, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Immunohorizons. 2020 04 23; 4(4):201-215. Schreiner P, Harrer T, Scheibenbogen C, Lamer S, Schlosser A, Naviaux RK, Prusty BK. PMID: 32327453.
      View in: PubMed   Mentions:    Fields:    
    2. Lesch-Nyhan disease: I. Construction of expression vectors for hypoxanthine-guanine phosphoribosyltransferase (HGprt) enzyme and amyloid precursor protein (APP). Nucleosides Nucleotides Nucleic Acids. 2020; 39(6):905-922. Nguyen KV, Naviaux RK, Nyhan WL. PMID: 32312153.
      View in: PubMed   Mentions:    Fields:    
    3. Improved Dried Blood Spot-Based Metabolomics: A Targeted, Broad-Spectrum, Single-Injection Method. Metabolites. 2020 Feb 27; 10(3). Li K, Naviaux JC, Monk JM, Wang L, Naviaux RK. PMID: 32120852.
      View in: PubMed   Mentions:
    4. Perspective: Cell danger response Biology-The new science that connects environmental health with mitochondria and the rising tide of chronic illness. Mitochondrion. 2020 03; 51:40-45. Naviaux RK. PMID: 31877376.
      View in: PubMed   Mentions:    Fields:    
    5. Metabolic features of Gulf War illness. PLoS One. 2019; 14(7):e0219531. Naviaux RK, Naviaux JC, Li K, Wang L, Monk JM, Bright AT, Koslik HJ, Ritchie JB, Golomb BA. PMID: 31348786.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Reply to "Comment on: Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial, Nutrients 2018, 10, 369". Nutrients. 2019 05 22; 11(5). Adams JB, Audhya T, Geis E, Gehn E, Fimbres V, Pollard EL, Mitchell J, Ingram J, Hellmers R, Laake D, Matthews JS, Li K, Naviaux JC, Naviaux RK, Adams RL, Coleman DM, Quig DW. PMID: 31121871.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Incomplete Healing as a Cause of Aging: The Role of Mitochondria and the Cell Danger Response. Biology (Basel). 2019 May 11; 8(2). Naviaux RK. PMID: 31083530.
      View in: PubMed   Mentions:
    8. Identification of Maltase Glucoamylase as a Biomarker of Acute Kidney Injury in Patients with Cirrhosis. Crit Care Res Pract. 2019; 2019:5912804. Awdishu L, Tsunoda S, Pearlman M, Kokoy-Mondragon C, Ghassemian M, Naviaux RK, Patton HM, Mehta RL, Vijay B, RamachandraRao SP. PMID: 31179128.
      View in: PubMed   Mentions:
    9. A Mutation in the Mitochondrial Aspartate/Glutamate Carrier Leads to a More Oxidizing Intramitochondrial Environment and an Inflammatory Myopathy in Dutch Shepherd Dogs. J Neuromuscul Dis. 2019; 6(4):485-501. Shelton GD, Minor KM, Li K, Naviaux JC, Monk J, Wang L, Guzik E, Guo LT, Porcelli V, Gorgoglione R, Lasorsa FM, Leegwater PJ, Persico AM, Mickelson JR, Palmieri L, Naviaux RK. PMID: 31594244.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Metabolic features and regulation of the healing cycle-A new model for chronic disease pathogenesis and treatment. Mitochondrion. 2019 05; 46:278-297. Naviaux RK. PMID: 30099222.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder-A Randomized, Controlled 12-Month Trial. Nutrients. 2018 Mar 17; 10(3). Adams JB, Audhya T, Geis E, Gehn E, Fimbres V, Pollard EL, Mitchell J, Ingram J, Hellmers R, Laake D, Matthews JS, Li K, Naviaux JC, Naviaux RK, Adams RL, Coleman DM, Quig DW. PMID: 29562612.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    12. Antipurinergic therapy for autism-An in-depth review. Mitochondrion. 2018 11; 43:1-15. Naviaux RK. PMID: 29253638.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Novel mutation in the human HPRT1 gene and the Lesch-Nyhan disease. Nucleosides Nucleotides Nucleic Acids. 2017 Nov 02; 36(11):704-711. Nguyen KV, Naviaux RK, Nyhan WL. PMID: 29185864.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. A robust, single-injection method for targeted, broad-spectrum plasma metabolomics. Metabolomics. 2017; 13(10):122. Li K, Naviaux JC, Bright AT, Wang L, Naviaux RK. PMID: 28943831.
      View in: PubMed   Mentions: 2     Fields:    
    15. Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial. Ann Clin Transl Neurol. 2017 07; 4(7):491-505. Naviaux RK, Curtis B, Li K, Naviaux JC, Bright AT, Reiner GE, Westerfield M, Goh S, Alaynick WA, Wang L, Capparelli EV, Adams C, Sun J, Jain S, He F, Arellano DA, Mash LE, Chukoskie L, Lincoln A, Townsend J. PMID: 28695149.
      View in: PubMed   Mentions: 13     Fields:    
    16. Lesch-Nyhan disease in two families from Chiloé Island with mutations in the HPRT1 gene. Nucleosides Nucleotides Nucleic Acids. 2017 Jul 03; 36(7):452-462. Nguyen KV, Silva S, Troncoso M, Naviaux RK, Nyhan WL. PMID: 28524722.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Englerin A induces an acute inflammatory response and reveals lipid metabolism and ER stress as targetable vulnerabilities in renal cell carcinoma. PLoS One. 2017; 12(3):e0172632. Batova A, Altomare D, Creek KE, Naviaux RK, Wang L, Li K, Green E, Williams R, Naviaux JC, Diccianni M, Yu AL. PMID: 28296891.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Utility of Spot Urine Specimens to Assess Tubular Secretion. Am J Kidney Dis. 2017 May; 69(5):709-711. Garimella PS, Li K, Naviaux JC, Shlipak MG, Abdelmalek JA, Castro E, Capparelli EV, Naviaux RK, Ix JH. PMID: 28284759.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice. Psychopharmacology (Berl). 2017 05; 234(9-10):1573-1586. Higa KK, Grim A, Kamenski ME, van Enkhuizen J, Zhou X, Li K, Naviaux JC, Wang L, Naviaux RK, Geyer MA, Markou A, Young JW. PMID: 28243714.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. Reply to Roerink et al.: Metabolomics of chronic fatigue syndrome. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):E911-E912. Naviaux RK, Gordon E. PMID: 28126717.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Human HPRT1 gene and the Lesch-Nyhan disease: Substitution of alanine for glycine and inversely in the HGprt enzyme protein. Nucleosides Nucleotides Nucleic Acids. 2017 Feb; 36(2):151-157. Nguyen KV, Naviaux RK, Nyhan WL. PMID: 28045594.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Reply to Vogt et al.: Metabolomics and chronic fatigue syndrome. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):E7142-E7143. Naviaux RK, Naviaux JC, Li K, Bright AT, Alaynick WA, Wang L, Baxter A, Nathan N, Anderson W, Gordon E. PMID: 27810963.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Metabolic features of chronic fatigue syndrome. Proc Natl Acad Sci U S A. 2016 Sep 13; 113(37):E5472-80. Naviaux RK, Naviaux JC, Li K, Bright AT, Alaynick WA, Wang L, Baxter A, Nathan N, Anderson W, Gordon E. PMID: 27573827.
      View in: PubMed   Mentions: 45     Fields:    
    24. Neurometabolic Disorders: Potentially Treatable Abnormalities in Patients With Treatment-Refractory Depression and Suicidal Behavior. Am J Psychiatry. 2017 Jan 01; 174(1):42-50. Pan LA, Martin P, Zimmer T, Segreti AM, Kassiff S, McKain BW, Baca CA, Rengasamy M, Hyland K, Walano N, Steinfeld R, Hughes M, Dobrowolski SK, Pasquino M, Diler R, Perel J, Finegold DN, Peters DG, Naviaux RK, Brent DA, Vockley J. PMID: 27523499.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. Proteomic analyses of Urine Exosomes reveal New Biomarkers of Diabetes in Pregnancy. Madridge J Diabetes. 2016; 1(1):11-22. Ramachandrarao SP, Hamlin AA, Awdishu L, Overcash R, Zhou M, Proudfoot J, Ishaya M, Aghania E, Madrigal A, Kokoy-Mondragon C, Kao K, Khoshaba R, Bounkhoun A, Ghassemian M, Tarsa M, Naviaux RK. PMID: 31448371.
      View in: PubMed   Mentions:
    26. High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):8714-9. Wall CE, Whyte J, Suh JM, Fan W, Collins B, Liddle C, Yu RT, Atkins AR, Naviaux JC, Li K, Bright AT, Alaynick WA, Downes M, Naviaux RK, Evans RM. PMID: 26124126.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    27. Correction: Proteomic analysis of urine exosomes reveals renal tubule response to leptospiral colonization in experimentally infected rats. PLoS Negl Trop Dis. 2015 Apr; 9(4):e0003718. RamachandraRao SP, Matthias MA, Kokoy-Mondrogon C, Aghania E, Park C, Kong C, Ishaya M, Madrigal A, Horng J, Khoshaba R, Bounkhoun A, Basilico F, De Palma A, Agresta AM, Awdishu L, Naviaux RK, Vinetz JM, Mauri P. PMID: 25860882.
      View in: PubMed   Mentions: 1     Fields:    
    28. Proteomic analysis of urine exosomes reveals renal tubule response to leptospiral colonization in experimentally infected rats. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003640. RamachandraRao SP, Matthias MA, Kokoy-Mondragon C, Mondrogon CK, Aghania E, Park C, Kong C, Ishaya M, Madrigal A, Horng J, Khoshaba R, Bounkhoun A, Basilico F, De Palma A, Agresta AM, Awdishu L, Naviaux RK, Vinetz JM, Mauri P. PMID: 25793258.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model. Mol Autism. 2015; 6:1. Naviaux JC, Wang L, Li K, Bright AT, Alaynick WA, Williams KR, Powell SB, Naviaux RK. PMID: 25705365.
      View in: PubMed   Mentions: 17     Fields:    
    30. Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy. Transl Psychiatry. 2014 Jun 17; 4:e400. Naviaux JC, Schuchbauer MA, Li K, Wang L, Risbrough VB, Powell SB, Naviaux RK. PMID: 24937094.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    31. Regulation of lipid accumulation by AMP-activated kinase [corrected] in high fat diet-induced kidney injury. Kidney Int. 2014 Mar; 85(3):611-23. Declèves AE, Zolkipli Z, Satriano J, Wang L, Nakayama T, Rogac M, Le TP, Nortier JL, Farquhar MG, Naviaux RK, Sharma K. PMID: 24304883.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    32. A model-driven quantitative metabolomics analysis of aerobic and anaerobic metabolism in E. coli K-12 MG1655 that is biochemically and thermodynamically consistent. Biotechnol Bioeng. 2014 Apr; 111(4):803-15. McCloskey D, Gangoiti JA, King ZA, Naviaux RK, Barshop BA, Palsson BO, Feist AM. PMID: 24249002.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    33. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest. 2013 Nov; 123(11):4888-99. Dugan LL, You YH, Ali SS, Diamond-Stanic M, Miyamoto S, DeCleves AE, Andreyev A, Quach T, Ly S, Shekhtman G, Nguyen W, Chepetan A, Le TP, Wang L, Xu M, Paik KP, Fogo A, Viollet B, Murphy A, Brosius F, Naviaux RK, Sharma K. PMID: 24135141.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    34. Assessing bioenergetic compromise in autism spectrum disorder with 31P magnetic resonance spectroscopy: preliminary report. J Child Neurol. 2014 Feb; 29(2):187-93. Golomb BA, Erickson LC, Scott-Van Zeeland AA, Koperski S, Haas RH, Wallace DC, Naviaux RK, Lincoln AJ, Reiner GE, Hamilton G. PMID: 24141271.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol. 2013 Nov; 24(11):1901-12. Sharma K, Karl B, Mathew AV, Gangoiti JA, Wassel CL, Saito R, Pu M, Sharma S, You YH, Wang L, Diamond-Stanic M, Lindenmeyer MT, Forsblom C, Wu W, Ix JH, Ideker T, Kopp JB, Nigam SK, Cohen CD, Groop PH, Barshop BA, Natarajan L, Nyhan WL, Naviaux RK. PMID: 23949796.
      View in: PubMed   Mentions: 120     Fields:    Translation:Humans
    36. Metabolic features of the cell danger response. Mitochondrion. 2014 May; 16:7-17. Naviaux RK. PMID: 23981537.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    37. AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. Cell. 2013 Aug 01; 154(3):505-17. Akizu N, Cantagrel V, Schroth J, Cai N, Vaux K, McCloskey D, Naviaux RK, Van Vleet J, Fenstermaker AG, Silhavy JL, Scheliga JS, Toyama K, Morisaki H, Sonmez FM, Celep F, Oraby A, Zaki MS, Al-Baradie R, Faqeih EA, Saleh MA, Spencer E, Rosti RO, Scott E, Nickerson E, Gabriel S, Morisaki T, Holmes EW, Gleeson JG. PMID: 23911318.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    38. Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model. PLoS One. 2013; 8(3):e57380. Naviaux RK, Zolkipli Z, Wang L, Nakayama T, Naviaux JC, Le TP, Schuchbauer MA, Rogac M, Tang Q, Dugan LL, Powell SB. PMID: 23516405.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    39. Alpers-Huttenlocher syndrome. Pediatr Neurol. 2013 Mar; 48(3):167-78. Saneto RP, Cohen BH, Copeland WC, Naviaux RK. PMID: 23419467.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    40. Lesch-Nyhan syndrome: mRNA expression of HPRT in patients with enzyme proven deficiency of HPRT and normal HPRT coding region of the DNA. Mol Genet Metab. 2012 Aug; 106(4):498-501. Nguyen KV, Naviaux RK, Paik KK, Nyhan WL. PMID: 22766437.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    41. Oxidative shielding or oxidative stress? J Pharmacol Exp Ther. 2012 Sep; 342(3):608-18. Naviaux RK. PMID: 22700427.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    42. Mitochondrial and ion channel gene alterations in autism. Biochim Biophys Acta. 2012 Oct; 1817(10):1796-802. Smith M, Flodman PL, Gargus JJ, Simon MT, Verrell K, Haas R, Reiner GE, Naviaux R, Osann K, Spence MA, Wallace DC. PMID: 22538295.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsCTClinical Trials
    43. Lesch-Nyhan variant syndrome: real-time rt-PCR for mRNA quantification in variable presentation in three affected family members. Nucleosides Nucleotides Nucleic Acids. 2012; 31(8):616-29. Nguyen KV, Naviaux RK, Paik KK, Nakayama T, Nyhan WL. PMID: 22908952.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa. Clin Transl Sci. 2012 Feb; 5(1):43-7. Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Perkins G, Murphy AN, Naviaux R, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. PMID: 22376256.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    45. Novel mutations in the human HPRT gene. Nucleosides Nucleotides Nucleic Acids. 2011 Jun; 30(6):440-5. Nguyen KV, Naviaux RK, Paik KK, Nyhan WL. PMID: 21780909.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    46. Fibroblast immuno-diagnosis of cytochrome oxidase (COX) deficiency in mitochondrial disease. Mitochondrion. 2011 May; 11(3):430-6. Du A, Naviaux RK, Le T, Xu C, Sommer SS, Haas RH. PMID: 21187165.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    47. Novel mutations in the human MCCA and MCCB gene causing methylcrotonylglycinuria. Mol Genet Metab. 2011 Feb; 102(2):218-21. Nguyen KV, Naviaux RK, Patra S, Barshop BA, Nyhan WL. PMID: 21071250.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    48. Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene. Circ Cardiovasc Genet. 2010 Oct; 3(5):414-25. Gayen JR, Zhang K, RamachandraRao SP, Mahata M, Chen Y, Kim HS, Naviaux RK, Sharma K, Mahata SK, O'Connor DT. PMID: 20729505.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    49. The clinical diagnosis of POLG disease and other mitochondrial DNA depletion disorders. Methods. 2010 Aug; 51(4):364-73. Cohen BH, Naviaux RK. PMID: 20558295.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    50. POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders. Seizure. 2010 Apr; 19(3):140-6. Saneto RP, Lee IC, Koenig MK, Bao X, Weng SW, Naviaux RK, Wong LJ. PMID: 20138553.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    51. Polymerase gamma disease through the ages. Dev Disabil Res Rev. 2010; 16(2):163-74. Saneto RP, Naviaux RK. PMID: 20818731.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    52. The GAAS metagenomic tool and its estimations of viral and microbial average genome size in four major biomes. PLoS Comput Biol. 2009 Dec; 5(12):e1000593. Angly FE, Willner D, Prieto-Davó A, Edwards RA, Schmieder R, Vega-Thurber R, Antonopoulos DA, Barott K, Cottrell MT, Desnues C, Dinsdale EA, Furlan M, Haynes M, Henn MR, Hu Y, Kirchman DL, McDole T, McPherson JD, Meyer F, Miller RM, Mundt E, Naviaux RK, Rodriguez-Mueller B, Stevens R, Wegley L, Zhang L, Zhu B, Rohwer F. PMID: 20011103.
      View in: PubMed   Mentions: 94     Fields:    
    53. De novo mutation in POLG leads to haplotype insufficiency and Alpers syndrome. Mitochondrion. 2009 Sep; 9(5):340-5. Chan SS, Naviaux RK, Basinger AA, Casas KA, Copeland WC. PMID: 19501198.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    54. Monitoring phosphorylation of the pyruvate dehydrogenase complex. Anal Biochem. 2009 Jun 15; 389(2):157-64. Rardin MJ, Wiley SE, Naviaux RK, Murphy AN, Dixon JE. PMID: 19341700.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    55. Retained features of embryonic metabolism in the adult MRL mouse. Mol Genet Metab. 2009 Mar; 96(3):133-44. Naviaux RK, Le TP, Bedelbaeva K, Leferovich J, Gourevitch D, Sachadyn P, Zhang XM, Clark L, Heber-Katz E. PMID: 19131261.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    56. Determination of DNA mutation load in human tissues using denaturing HPLC-based heteroduplex analysis. Methods Mol Biol. 2009; 554:287-99. Lim KS, Naviaux RK, Haas RH. PMID: 19513681.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    57. Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Hum Mutat. 2008 Sep; 29(9):E150-72. Wong LJ, Naviaux RK, Brunetti-Pierri N, Zhang Q, Schmitt ES, Truong C, Milone M, Cohen BH, Wical B, Ganesh J, Basinger AA, Burton BK, Swoboda K, Gilbert DL, Vanderver A, Saneto RP, Maranda B, Arnold G, Abdenur JE, Waters PJ, Copeland WC. PMID: 18546365.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    58. Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse. Mitochondrion. 2008 Dec; 8(5-6):358-66. Sachadyn P, Zhang XM, Clark LD, Naviaux RK, Heber-Katz E. PMID: 18761428.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    59. Mitochondrial control of epigenetics. Cancer Biol Ther. 2008 Aug; 7(8):1191-3. Naviaux RK. PMID: 18719362.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    60. Impact of nucleoside reverse transcriptase inhibitors on mitochondrial DNA and RNA in human skeletal muscle cells. Antimicrob Agents Chemother. 2008 Aug; 52(8):2825-30. Saitoh A, Haas RH, Naviaux RK, Salva NG, Wong JK, Spector SA. PMID: 18541728.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    61. The in-depth evaluation of suspected mitochondrial disease. Mol Genet Metab. 2008 May; 94(1):16-37. Haas RH, Parikh S, Falk MJ, Saneto RP, Wolf NI, Darin N, Wong LJ, Cohen BH, Naviaux RK. PMID: 18243024.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    62. Pitfalls in the denaturing high-performance liquid chromatography analysis of mitochondrial DNA mutation. J Mol Diagn. 2008 Jan; 10(1):102-8. Lim KS, Naviaux RK, Wong S, Haas RH. PMID: 18165269.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    63. Reactive biomolecular divergence in genetically altered yeast cells and isolated mitochondria as measured by biocavity laser spectroscopy: rapid diagnostic method for studying cellular responses to stress and disease. J Biomed Opt. 2007 Sep-Oct; 12(5):054003. Gourley PL, Hendricks JK, McDonald AE, Copeland RG, Yaffe MP, Naviaux RK. PMID: 17994891.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    64. ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart. Cell Metab. 2007 Jul; 6(1):13-24. Alaynick WA, Kondo RP, Xie W, He W, Dufour CR, Downes M, Jonker JW, Giles W, Naviaux RK, Giguère V, Evans RM. PMID: 17618853.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    65. Defects in maintenance of mitochondrial DNA are associated with intramitochondrial nucleotide imbalances. Hum Mol Genet. 2007 Jun 15; 16(12):1400-11. Ashley N, Adams S, Slama A, Zeviani M, Suomalainen A, Andreu AL, Naviaux RK, Poulton J. PMID: 17483096.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    66. Quantitative mitochondrial DNA mutation analysis by denaturing HPLC. Clin Chem. 2007 Jun; 53(6):1046-52. Lim KS, Naviaux RK, Haas RH. PMID: 17446331.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    67. Meeting report: mitochondrial DNA and cancer epidemiology. Cancer Res. 2007 Jan 15; 67(2):437-9. Verma M, Naviaux RK, Tanaka M, Kumar D, Franceschi C, Singh KK. PMID: 17213255.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    68. Mitochondrial DNA mutation detection by electrospray mass spectrometry. Clin Chem. 2007 Feb; 53(2):195-203. Jiang Y, Hall TA, Hofstadler SA, Naviaux RK. PMID: 17158195.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    69. Molecular diagnosis of Alpers syndrome. J Hepatol. 2006 Jul; 45(1):108-16. Nguyen KV, Sharief FS, Chan SS, Copeland WC, Naviaux RK. PMID: 16545482.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    70. Mitochondrial correlation microscopy and nanolaser spectroscopy - new tools for biophotonic detection of cancer in single cells. Technol Cancer Res Treat. 2005 Dec; 4(6):585-92. Gourley PL, Hendricks JK, McDonald AE, Copeland RG, Barrett KE, Gourley CR, Singh KK, Naviaux RK. PMID: 16292878.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    71. Ultrafast nanolaser flow device for detecting cancer in single cells. Biomed Microdevices. 2005 Dec; 7(4):331-9. Gourley PL, Hendricks JK, McDonald AE, Copeland RG, Barrett KE, Gourley CR, Naviaux RK. PMID: 16404511.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    72. POLG mutations in Alpers syndrome. Neurology. 2005 Nov 08; 65(9):1493-5. Nguyen KV, Østergaard E, Ravn SH, Balslev T, Danielsen ER, Vardag A, McKiernan PJ, Gray G, Naviaux RK. PMID: 16177225.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    73. Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome. DNA Repair (Amst). 2005 Dec 08; 4(12):1381-9. Chan SS, Longley MJ, Naviaux RK, Copeland WC. PMID: 16181814.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    74. POLG mutations associated with Alpers syndrome and mitochondrial DNA depletion. Ann Neurol. 2005 Sep; 58(3):491. Naviaux RK, Nguyen KV. PMID: 16130100.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    75. Oxygen consumption by cultured human cells is impaired by a nucleoside analogue cocktail that inhibits mitochondrial DNA synthesis. Mitochondrion. 2005 Jun; 5(3):154-61. Petit C, Piétri-Rouxel F, Lesne A, Leste-Lasserre T, Mathez D, Naviaux RK, Sonigo P, Bouillaud F, Leibowitch J. PMID: 16050981.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    76. Statin myotoxicity is associated with changes in the cardiopulmonary function. Atherosclerosis. 2004 Nov; 177(1):183-8. Phillips PS, Phillips CT, Sullivan MJ, Naviaux RK, Haas RH. PMID: 15488882.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    77. Chronic treatment of mitochondrial disease patients with dichloroacetate. Mol Genet Metab. 2004 Sep-Oct; 83(1-2):138-49. Barshop BA, Naviaux RK, McGowan KA, Levine F, Nyhan WL, Loupis-Geller A, Haas RH. PMID: 15464428.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    78. Developing a systematic approach to the diagnosis and classification of mitochondrial disease. Mitochondrion. 2004 Sep; 4(5-6):351-61. Naviaux RK. PMID: 16120397.
      View in: PubMed   Mentions: 13     Fields:    
    79. POLG mutations associated with Alpers' syndrome and mitochondrial DNA depletion. Ann Neurol. 2004 May; 55(5):706-12. Naviaux RK, Nguyen KV. PMID: 15122711.
      View in: PubMed   Mentions: 109     Fields:    Translation:Humans
    80. The role of methionine in ethylmalonic encephalopathy with petechiae. Arch Neurol. 2004 Apr; 61(4):570-4. McGowan KA, Nyhan WL, Barshop BA, Naviaux RK, Yu A, Haas RH, Townsend JJ. PMID: 15096407.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    81. Quantitation of blood lymphocyte mitochondrial DNA for the monitoring of antiretroviral drug-induced mitochondrial DNA depletion. J Acquir Immune Defic Syndr. 2003 Aug 01; 33(4):461-9. Petit C, Mathez D, Barthélémy C, Leste-Lasserre T, Naviaux RK, Sonigo P, Leibowitch J. PMID: 12869834.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    82. Pyruvate carboxylase deficiency--insights from liver transplantation. Mol Genet Metab. 2002 Sep-Oct; 77(1-2):143-9. Nyhan WL, Khanna A, Barshop BA, Naviaux RK, Precht AF, Lavine JE, Hart MA, Hainline BE, Wappner RS, Nichols S, Haas RH. PMID: 12359142.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    83. The otolaryngological manifestations of mitochondrial disease and the risk of neurodegeneration with infection. Arch Otolaryngol Head Neck Surg. 2002 Apr; 128(4):355-62. Edmonds JL, Kirse DJ, Kearns D, Deutsch R, Spruijt L, Naviaux RK. PMID: 11926907.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    84. Assay of mtDNA polymerase gamma from human tissues. Methods Mol Biol. 2002; 197:259-71. Naviaux RK. PMID: 12013801.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    85. Need for public debate about fertility treatments. Nature. 2001 Sep 27; 413(6854):347. Naviaux RK, Singh KK. PMID: 11574848.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    86. Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate. Muscle Nerve. 2001 Jul; 24(7):916-24. Spruijt L, Naviaux RK, McGowan KA, Nyhan WL, Sheean G, Haas RH, Barshop BA. PMID: 11410919.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCellsCTClinical Trials
    87. Medium-chain acyl coenzyme A dehydrogenase deficiency: occurrence in an infant and his father. Arch Neurol. 2001 May; 58(5):811-4. Bodman M, Smith D, Nyhan WL, Naviaux RK. PMID: 11346377.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    88. Mitochondrial DNA depletion associated with partial complex II and IV deficiencies and 3-methylglutaconic aciduria. J Child Neurol. 2001 Feb; 16(2):136-8. Scaglia F, Sutton VR, Bodamer OA, Vogel H, Shapira SK, Naviaux RK, Vladutiu GD. PMID: 11292221.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    89. Mitochondrial DNA disorders. Eur J Pediatr. 2000 Dec; 159 Suppl 3:S219-26. Naviaux RK. PMID: 11216904.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    90. Organismal effects of mitochondrial dysfunction. Hum Reprod. 2000 Jul; 15 Suppl 2:44-56. Naviaux RK, McGowan KA. PMID: 11041512.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    91. Autism associated with the mitochondrial DNA G8363A transfer RNA(Lys) mutation. J Child Neurol. 2000 Jun; 15(6):357-61. Graf WD, Marin-Garcia J, Gao HG, Pizzo S, Naviaux RK, Markusic D, Barshop BA, Courchesne E, Haas RH. PMID: 10868777.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    92. Kearns-Sayre syndrome presenting as 2-oxoadipic aciduria. Mol Genet Metab. 2000 Jan; 69(1):64-8. Barshop BA, Nyhan WL, Naviaux RK, McGowan KA, Friedlander M, Haas RH. PMID: 10655159.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    93. Sensitive assay for mitochondrial DNA polymerase gamma. Clin Chem. 1999 Oct; 45(10):1725-33. Naviaux RK, Markusic D, Barshop BA, Nyhan WL, Haas RH. PMID: 10508117.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    94. Mitochondrial DNA polymerase gamma deficiency and mtDNA depletion in a child with Alpers' syndrome. Ann Neurol. 1999 Jan; 45(1):54-8. Naviaux RK, Nyhan WL, Barshop BA, Poulton J, Markusic D, Karpinski NC, Haas RH. PMID: 9894877.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    95. Restoration of growth arrest by p16INK4, p21WAF1, pRB, and p53 is dependent on the integrity of the endogenous cell-cycle control pathways in human glioblastoma cell lines. Exp Cell Res. 1998 Jan 10; 238(1):51-62. Costanzi-Strauss E, Strauss BE, Naviaux RK, Haas M. PMID: 9457056.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    96. The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J Virol. 1996 Aug; 70(8):5701-5. Naviaux RK, Costanzi E, Haas M, Verma IM. PMID: 8764092.
      View in: PubMed   Mentions: 252     Fields:    Translation:HumansCells
    97. Cytokine gene therapy with interleukin-2-transduced fibroblasts: effects of IL-2 dose on anti-tumor immunity. Hum Gene Ther. 1995 May; 6(5):591-601. Fakhrai H, Shawler DL, Gjerset R, Naviaux RK, Koziol J, Royston I, Sobol RE. PMID: 7578396.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    98. Gene therapy via primary myoblasts: long-term expression of factor IX protein following transplantation in vivo. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10892-5. Dai Y, Roman M, Naviaux RK, Verma IM. PMID: 1332058.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    99. Retroviral vectors for persistent expression in vivo. Curr Opin Biotechnol. 1992 Oct; 3(5):540-7. Naviaux RK, Verma IM. PMID: 1368938.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    100. Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle. Somat Cell Mol Genet. 1992 May; 18(3):247-58. Roman M, Axelrod JH, Dai Y, Naviaux RK, Friedmann T, Verma IM. PMID: 1496420.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    101. Human gene therapy. Curr Opin Genet Dev. 1991 Jun; 1(1):54-9. Verma IM, Naviaux RK. PMID: 1840879.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    102. Construction and characterization of two infectious molecular clones of encephalomyocarditis virus. J Virol. 1990 Feb; 64(2):913-7. Naviaux RK, Cohen SH, Vanden Brink KM, Jordan GW. PMID: 2153252.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    103. Comparison of the nucleotide sequences of diabetogenic and nondiabetogenic encephalomyocarditis virus. Virology. 1988 Oct; 166(2):603-7. Cohen SH, Naviaux RK, vanden Brink KM, Jordan GW. PMID: 2845665.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    104. Micro competition enzyme linked immunosorbant assay for human apolipoprotein B. Ann Clin Lab Sci. 1986 Jul-Aug; 16(4):278-88. Unune A, Naviaux RK, Christian JC, Goldstein DJ. PMID: 3740797.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    105. Microimmunoassay permits determination of concentrations in immunohistochemistry controls. J Histochem Cytochem. 1986 Apr; 34(4):543-5. Goldstein DJ, Davis MM, Naviaux RK, Dailey TL, Ulbright TM. PMID: 2419398.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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