Farah Sheikh

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    McMaster University, Hamilton, CanadaBSc06/1994Biology
    University of Manitoba, Winnipeg, CanadaMSc (transitioned)09/1996Physiology (Cardiovascular)
    University of Manitoba, Winnipeg, CanadaPhD10/2001Physiology (Cardiovascular)
    University of California-San Diego, La Jolla, CAPDF12/2006Molecular Cardiology

    Collapse Overview 
    Collapse Overview
    My laboratory is focused on better understanding the pathways driving biomechanical stress responses in cardiac muscle as they are major triggers for human genetic-based cardiac diseases. More recently, our major efforts have centralized on complexes at the cardiac muscle cell-cell junction as genetic mutations/deficiencies in components associated with this complex drive the devastating “athlete’s” heart muscle disease, arrhythmogenic right ventricular cardiomyopathy (ARVC), that results in sudden death. We exploit genetically engineered mouse models and induced pluripotent stem cells (iPSCs) from human patients, miniaturized physiological assays, and a range of molecular and cell biological techniques, including yeast-two-hybrid screens to uncover novel protein interactions that may drive cardiac disease pathogenesis. Through collaborations with prominent investigators in the bioengineering/nanoengineering departments, we have exploited in vitro model systems (eg. aligned cardiomyocyte mouse models, co-culture devices, specialized cardiac extracellular matrix coatings, 3D printing) that have uncovered early mechanisms and unconventional roles for cell-cell junction proteins in cardiac muscle, conduction, maturity and human cardiac disease. In this manner, we are developing a comprehensive understanding of the complex role for the cell-cell junction network and its requirement for optimal cardiac function both in vitro and in vivo.

    Collapse Research 
    Collapse Research Activities and Funding
    Implementing Novel therapeutics to Restore Cardiomyocyte Physiology and Circumvent Sudden Death in Arrhythmogenic Heart Disease.
    Department of Defense W81XWH-17-PRMRP-IIRASep 1, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Uncovering New Functions of CSN6 in Cardiac Desmosomal Biology and Disease
    NIH R01HL142251Aug 1, 2018 - Jul 31, 2022
    Role: Principal Investigator
    The Role of CSN6 in Cardiac Muscle and Sudden Cardiac Death
    Tobacco Related Disease Research Program 24RT-022Jul 1, 2015 - Jun 30, 2018
    Role: Principal Investigator
    Uncovering New Disease Mechanisms Underlying Arrhythmogenic Right Ventricular Cardiomyopathy using Human iPSC
    American Heart Association 15GRNT22940045Jan 1, 2015 - Dec 31, 2016
    Role: Principal Investigator
    Molecular Mechanisms Underlying Human Cardiac Cell Junction Maturation and Disease Using Human iPSC
    California Institute of Regenerative Medicine RB3-05103Jul 1, 2011 - Jun 30, 2014
    Role: Principal Investigator
    Enhanced cardiomyocyte differentiation and maturation using myocardial matrix
    NIH R21HL104493Jul 15, 2010 - Jun 30, 2012
    Role: Principal Investigator
    The molecular mechanisms underlying arrhythmogenic right ventricular dysplasia/cardiomyopathy
    NIH R01HL095780Apr 1, 2009 - Mar 31, 2019
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Life Sci. 2023 Oct 01; 330:122028. Sheikh F. PMID: 37597768.
      View in: PubMed   Mentions:    Fields:    
    2. Recurrent Myocarditis in Patients With Desmosomal Pathogenic Variants: Is Self Antigen Presentation the Link? JACC Clin Electrophysiol. 2023 Sep; 9(9):2024-2033. Mayfield JJ, Bogomolovas J, Abraham MR, Sullivan K, Seo Y, Sheikh F, Scheinman M. PMID: 37480874.
      View in: PubMed   Mentions:    Fields:    
    3. Calcium "stress" adds a third hit in driving heart failure with preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2023 04 01; 324(4):H414-H416. Fujita K, Ellis MW, Sheikh F. PMID: 36763507; PMCID: PMC9988519.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by Involving an Integrin-αVβ6/TGF-β Signaling Cascade. Circulation. 2022 11 22; 146(21):1610-1626. Schinner C, Xu L, Franz H, Zimmermann A, Wanuske MT, Rathod M, Hanns P, Geier F, Pelczar P, Liang Y, Lorenz V, Stüdle C, Maly PI, Kauferstein S, Beckmann BM, Sheikh F, Kuster GM, Spindler V. PMID: 36268721; PMCID: PMC9674449.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    5. Functions Beyond the Editor's I in Regulating Cardiac Innate Immunity and Heart Failure. Circ Res. 2022 09 16; 131(7):598-600. Zhang J, Gutierrez-Lara EJ, Liang Y, Sheikh F. PMID: 36108055; PMCID: PMC10068842.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles. Biophys Rev. 2021 Oct; 13(5):653-677. van der Pijl RJ, Domenighetti AA, Sheikh F, Ehler E, Ottenheijm CAC, Lange S. PMID: 34745373; PMCID: PMC8553726.
      View in: PubMed   Mentions: 5  
    7. Desmosomes: emerging pathways and non-canonical functions in cardiac arrhythmias and disease. Biophys Rev. 2021 Oct; 13(5):697-706. Zhang J, Liang Y, Bradford WH, Sheikh F. PMID: 34765046; PMCID: PMC8555023.
      View in: PubMed   Mentions: 6  
    8. Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest. 2021 06 01; 131(11). Liang Y, Lyon RC, Pellman J, Bradford WH, Lange S, Bogomolovas J, Dalton ND, Gu Y, Bobar M, Lee MH, Iwakuma T, Nigam V, Asimaki A, Scheinman M, Peterson KL, Sheikh F. PMID: 33857019; PMCID: PMC8159691.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin). Hypertension. 2021 05 05; 77(5):1670-1682. Ying W, Tang K, Avolio E, Schilling JM, Pasqua T, Liu MA, Cheng H, Gao H, Zhang J, Mahata S, Ko MS, Bandyopadhyay G, Das S, Roth DM, Sahoo D, Webster NJG, Sheikh F, Ghosh G, Patel HH, Ghosh P, van den Bogaart G, Mahata SK. PMID: 33826401; PMCID: PMC8116433.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    10. Zippering Up a Role for ZO-1 in Atrioventricular Node Conduction and Disease. Circ Res. 2020 07 03; 127(2):298-300. Liang Y, Sheikh F. PMID: 32614716; PMCID: PMC8204722.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    11. Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43. J Cell Biol. 2018 09 03; 217(9):3219-3235. Kam CY, Dubash AD, Magistrati E, Polo S, Satchell KJF, Sheikh F, Lampe PD, Green KJ. PMID: 29959233; PMCID: PMC6123000.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    12. Four and a half LIM domain protein signaling and cardiomyopathy. Biophys Rev. 2018 Aug; 10(4):1073-1085. Liang Y, Bradford WH, Zhang J, Sheikh F. PMID: 29926425; PMCID: PMC6082310.
      View in: PubMed   Mentions: 25  
    13. Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2018 06; 11(6):e000046. Musunuru K, Arora P, Cooke JP, Ferguson JF, Hershberger RE, Hickey KT, Lee JM, Lima JAC, Loscalzo J, Pereira NL, Russell MW, Shah SH, Sheikh F, Wang TJ, MacRae CA, American Heart Association Council on Genomic and Precision Medicine; Council on Cardiovascular Dise. PMID: 29844141; PMCID: PMC6708587.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    14. Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. Nat Commun. 2018 01 17; 9(1):262. Krysiak J, Unger A, Beckendorf L, Hamdani N, von Frieling-Salewsky M, Redfield MM, Dos Remedios CG, Sheikh F, Gergs U, Boknik P, Linke WA. PMID: 29343782; PMCID: PMC5772059.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    15. Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2018 01; 11(1):e000043. Musunuru K, Sheikh F, Gupta RM, Houser SR, Maher KO, Milan DJ, Terzic A, Wu JC, American Heart Association Council on Functional Genomics and Translational Biology; Council on Card. PMID: 29874173; PMCID: PMC6708586.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    16. Vinculin at the heart of aging. Ann Transl Med. 2017 Feb; 5(3):62. Bradford WH, Omens JH, Sheikh F. PMID: 28251141; PMCID: PMC5326649.
      View in: PubMed   Mentions: 3  
    17. Desmosomal junctions are necessary for adult sinus node function. Cardiovasc Res. 2016 08 01; 111(3):274-86. Mezzano V, Liang Y, Wright AT, Lyon RC, Pfeiffer E, Song MY, Gu Y, Dalton ND, Scheinman M, Peterson KL, Evans SM, Fowler S, Cerrone M, McCulloch AD, Sheikh F. PMID: 27097650; PMCID: PMC4957488.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    18. Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: Mechanisms and model systems. J Mol Cell Cardiol. 2016 05; 94:22-31. Pellman J, Zhang J, Sheikh F. PMID: 26996756; PMCID: PMC4861678.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    19. Scaffold Proteins Regulating Extracellular Regulated Kinase Function in Cardiac Hypertrophy and Disease. Front Pharmacol. 2016; 7:37. Liang Y, Sheikh F. PMID: 26973524; PMCID: PMC4770026.
      View in: PubMed   Mentions: 10  
    20. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2206-11. Ma X, Qu X, Zhu W, Li YS, Yuan S, Zhang H, Liu J, Wang P, Lai CS, Zanella F, Feng GS, Sheikh F, Chien S, Chen S. PMID: 26858399; PMCID: PMC4776497.
      View in: PubMed   Mentions: 281     Fields:    Translation:HumansCells
    21. Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization of Cardiac Cells. Methods Mol Biol. 2016; 1353:147-62. Zanella F, Sheikh F. PMID: 25520292; PMCID: PMC5357616.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease. Gene. 2015 Sep 10; 569(1):14-20. Sheikh F, Lyon RC, Chen J. PMID: 26074085; PMCID: PMC4496279.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimals
    23. Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers. Cardiovasc Res. 2015 Jul 15; 107(2):216-25. Mastrototaro G, Liang X, Li X, Carullo P, Piroddi N, Tesi C, Gu Y, Dalton ND, Peterson KL, Poggesi C, Sheikh F, Chen J, Bang ML. PMID: 25987543; PMCID: PMC4565986.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    24. Mechanotransduction in cardiac hypertrophy and failure. Circ Res. 2015 Apr 10; 116(8):1462-1476. Lyon RC, Zanella F, Omens JH, Sheikh F. PMID: 25858069; PMCID: PMC4394185.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansAnimalsCells
    25. Atrial fibrillation: mechanisms, therapeutics, and future directions. Compr Physiol. 2015 Apr; 5(2):649-65. Pellman J, Sheikh F. PMID: 25880508; PMCID: PMC5240842.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    26. Women in science. Life Sci. 2015 Mar 15; 125:1. Sheikh F, Zanesco A. PMID: 25749606.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. A new mechanism links preamyloid oligomer formation in the myocyte stress response associated with atrial fibrillation. J Mol Cell Cardiol. 2015 Mar; 80:110-3. Pellman J, Sheikh F. PMID: 25541246; PMCID: PMC4346451.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    28. Cell junctions in the specialized conduction system of the heart. Cell Commun Adhes. 2014 Jun; 21(3):149-59. Mezzano V, Pellman J, Sheikh F. PMID: 24738884; PMCID: PMC4291170.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    29. Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Hum Mol Genet. 2014 Mar 01; 23(5):1134-50. Lyon RC, Mezzano V, Wright AT, Pfeiffer E, Chuang J, Banares K, Castaneda A, Ouyang K, Cui L, Contu R, Gu Y, Evans SM, Omens JH, Peterson KL, McCulloch AD, Sheikh F. PMID: 24108106; PMCID: PMC3919010.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    30. Modeling heart disease in a dish: from somatic cells to disease-relevant cardiomyocytes. Trends Cardiovasc Med. 2014 Jan; 24(1):32-44. Zanella F, Lyon RC, Sheikh F. PMID: 24054750; PMCID: PMC4969049.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    31. Cypher/ZASP is a novel A-kinase anchoring protein. J Biol Chem. 2013 Oct 11; 288(41):29403-13. Lin C, Guo X, Lange S, Liu J, Ouyang K, Yin X, Jiang L, Cai Y, Mu Y, Sheikh F, Ye S, Chen J, Ke Y, Cheng H. PMID: 23996002; PMCID: PMC3795241.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    32. Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Hum Mol Genet. 2014 Jan 01; 23(1):209-25. Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J. PMID: 23975679; PMCID: PMC3916749.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    33. Getting the skinny on thick filament regulation in cardiac muscle biology and disease. Trends Cardiovasc Med. 2014 May; 24(4):133-41. Sheikh F, Lyon RC, Chen J. PMID: 23968570; PMCID: PMC3877703.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    34. Assessment of skills using a virtual reality temporal bone surgery simulator. Acta Otorhinolaryngol Ital. 2013 Aug; 33(4):273-81. Linke R, Leichtle A, Sheikh F, Schmidt C, Frenzel H, Graefe H, Wollenberg B, Meyer JE. PMID: 24043916; PMCID: PMC3773961.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    35. Breaking down protein degradation mechanisms in cardiac muscle. Trends Mol Med. 2013 Apr; 19(4):239-49. Lyon RC, Lange S, Sheikh F. PMID: 23453282; PMCID: PMC3622835.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    36. Fibroblasts influence muscle progenitor differentiation and alignment in contact independent and dependent manners in organized co-culture devices. Biomed Microdevices. 2013 Feb; 15(1):161-9. Rao N, Evans S, Stewart D, Spencer KH, Sheikh F, Hui EE, Christman KL. PMID: 22983793; PMCID: PMC3537877.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    37. No contribution of IP3-R(2) to disease phenotype in models of dilated cardiomyopathy or pressure overload hypertrophy. Circ Heart Fail. 2013 Mar; 6(2):318-25. Cooley N, Ouyang K, McMullen JR, Kiriazis H, Sheikh F, Wu W, Mu Y, Du XJ, Chen J, Woodcock EA. PMID: 23258573; PMCID: PMC4028972.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    38. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem. 2012 Aug 24; 287(35):29273-84. Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. PMID: 22778266; PMCID: PMC3436149.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    39. Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model. Eur Cell Mater. 2012 Jun 05; 23:400-12; discussion 412. DeQuach JA, Lin JE, Cam C, Hu D, Salvatore MA, Sheikh F, Christman KL. PMID: 22665162; PMCID: PMC3524267.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    40. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest. 2012 Apr; 122(4):1209-21. Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. PMID: 22426213; PMCID: PMC3314469.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    41. Cell-cell junction remodeling in the heart: possible role in cardiac conduction system function and arrhythmias? Life Sci. 2012 Feb 27; 90(9-10):313-21. Mezzano V, Sheikh F. PMID: 22227473; PMCID: PMC3488940.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    42. Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet. 2011 May 01; 20(9):1751-62. Cheng H, Zheng M, Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans SM, Knowlton KU, Sheikh F, Chen J. PMID: 21303826; PMCID: PMC3071671.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    43. Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS One. 2010 Sep 27; 5(9):e13039. DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL. PMID: 20885963; PMCID: PMC2946408.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    44. Embryonic survival and severity of cardiac and craniofacial defects are affected by genetic background in fibroblast growth factor-16 null mice. DNA Cell Biol. 2010 Aug; 29(8):407-15. Lu SY, Jin Y, Li X, Sheppard P, Bock ME, Sheikh F, Duckworth ML, Cattini PA. PMID: 20618076.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    45. Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo. Circ Res. 2010 Mar 19; 106(5):880-90. Seeger TS, Frank D, Rohr C, Will R, Just S, Grund C, Lyon R, Luedde M, Koegl M, Sheikh F, Rottbauer W, Franke WW, Katus HA, Olson EN, Frey N. PMID: 20093627; PMCID: PMC2856095.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    46. Extracellular matrix remodeling in atrial fibrosis: mechanisms and implications in atrial fibrillation. J Mol Cell Cardiol. 2010 Mar; 48(3):461-7. Pellman J, Lyon RC, Sheikh F. PMID: 19751740; PMCID: PMC2823941.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    47. Cell-cell connection to cardiac disease. Trends Cardiovasc Med. 2009 Aug; 19(6):182-90. Sheikh F, Ross RS, Chen J. PMID: 20211433; PMCID: PMC3601820.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    48. Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol Cell Biol. 2009 Jan; 29(2):378-88. Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, Feng GS. PMID: 19001090; PMCID: PMC2612510.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    49. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. PMID: 19033658; PMCID: PMC2575833.
      View in: PubMed   Mentions: 134     Fields:    Translation:AnimalsCells
    50. FGF-16 is required for embryonic heart development. Biochem Biophys Res Commun. 2008 Aug 22; 373(2):270-4. Lu SY, Sheikh F, Sheppard PC, Fresnoza A, Duckworth ML, Detillieux KA, Cattini PA. PMID: 18565327; PMCID: PMC5233434.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    51. Mouse models for cardiomyopathy research. Prog Pediatric Cardiol. 2007; 24(1):25-32.
    52. "Z"eroing in on the role of Cypher in striated muscle function, signaling, and human disease. Trends Cardiovasc Med. 2007 Nov; 17(8):258-62. Sheikh F, Bang ML, Lange S, Chen J. PMID: 18021935; PMCID: PMC2134983.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    53. alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation. 2006 Sep 05; 114(10):1046-55. Sheikh F, Chen Y, Chen Y, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton ND, Yajima T, Lu Y, Knowlton KU, Peterson KL, Perriard JC, Chen J. PMID: 16923756.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    54. Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice. Circ Res. 2005 Jun 24; 96(12):1274-81. Li X, Zima AV, Sheikh F, Blatter LA, Chen J. PMID: 15933266.
      View in: PubMed   Mentions: 164     Fields:    Translation:AnimalsCells
    55. Inhibition of TGFbeta signaling potentiates the FGF-2-induced stimulation of cardiomyocyte DNA synthesis. Cardiovasc Res. 2004 Dec 01; 64(3):516-25. Sheikh F, Hirst CJ, Jin Y, Bock ME, Fandrich RR, Nickel BE, Doble BW, Kardami E, Cattini PA. PMID: 15537505.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    56. Fibroblast growth factor 2 isoforms and cardiac hypertrophy. Cardiovasc Res. 2004 Aug 15; 63(3):458-66. Kardami E, Jiang ZS, Jimenez SK, Hirst CJ, Sheikh F, Zahradka P, Cattini PA. PMID: 15276471.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    57. Transcriptional regulation of FGF-2 gene expression in cardiac myocytes. Cardiovasc Res. 2004 Jun 01; 62(3):548-57. Jimenez SK, Sheikh F, Jin Y, Detillieux KA, Dhaliwal J, Kardami E, Cattini PA. PMID: 15158147.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    58. Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis. Development. 2003 Dec; 130(24):6111-9. Huang C, Sheikh F, Hollander M, Cai C, Becker D, Chu PH, Evans S, Chen J. PMID: 14573518.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    59. Biological activities of fibroblast growth factor-2 in the adult myocardium. Cardiovasc Res. 2003 Jan; 57(1):8-19. Detillieux KA, Sheikh F, Kardami E, Cattini PA. PMID: 12504809.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    60. Characterization and in vivo functional analysis of splice variants of cypher. J Biol Chem. 2003 Feb 28; 278(9):7360-5. Huang C, Zhou Q, Liang P, Hollander MS, Sheikh F, Li X, Greaser M, Shelton GD, Evans S, Chen J. PMID: 12499364.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    61. Exacerbation of myocardial injury in transgenic mice overexpressing FGF-2 is T cell dependent. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H547-55. Meij JT, Sheikh F, Jimenez SK, Nickerson PW, Kardami E, Cattini PA. PMID: 11788402.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    62. Overexpression of FGF-2 increases cardiac myocyte viability after injury in isolated mouse hearts. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H1039-50. Sheikh F, Sontag DP, Fandrich RR, Kardami E, Cattini PA. PMID: 11179045.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    63. Role for early growth response-1 protein in alpha(1)-adrenergic stimulation of fibroblast growth factor-2 promoter activity in cardiac myocytes. Mol Pharmacol. 2000 May; 57(5):984-90. Jin Y, Sheikh F, Detillieux KA, Cattini PA. PMID: 10779383.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    64. Overexpression of long or short FGFR-1 results in FGF-2-mediated proliferation in neonatal cardiac myocyte cultures. Cardiovasc Res. 1999 Jun; 42(3):696-705. Sheikh F, Fandrich RR, Kardami E, Cattini PA. PMID: 10533610.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    65. Detection of 28S RNA with the FGF-2 cDNA at high stringency through related G/C-rich sequences. Mol Cell Biochem. 1998 Dec; 189(1-2):33-9. Cattini PA, Jin Y, Sheikh F. PMID: 9879651.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    66. Expression of fibroblast growth factor receptor-1 in rat heart H9c2 myoblasts increases cell proliferation. Mol Cell Biochem. 1997 Nov; 176(1-2):89-97. Sheikh F, Jin Y, Pasumarthi KB, Kardami E, Cattini PA. PMID: 9406149.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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