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    Farah Sheikh

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0613-C
    CA La Jolla 92093
    Phone858-246-0754
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Enhanced cardiomyocyte differentiation and maturation using myocardial matrix
      NIH/NHLBI R21HL104493Jul 15, 2010 - Jun 30, 2012
      Role: Principal Investigator
      The molecular mechanisms underlying arrhythmogenic right ventricular dysplasia/cardiomyopathy
      NIH/NHLBI R01HL095780Apr 1, 2009 - Mar 31, 2019
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Bradford WH, Omens JH, Sheikh F. Vinculin at the heart of aging. Ann Transl Med. 2017 Feb; 5(3):62. PMID: 28251141.
        View in: PubMed
      2. Mezzano V, Liang Y, Wright AT, Lyon RC, Pfeiffer E, Song MY, Gu Y, Dalton ND, Scheinman M, Peterson KL, Evans SM, Fowler S, Cerrone M, McCulloch AD, Sheikh F. Desmosomal junctions are necessary for adult sinus node function. Cardiovasc Res. 2016 Aug 1; 111(3):274-86. PMID: 27097650.
        View in: PubMed
      3. Pellman J, Zhang J, Sheikh F. Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: Mechanisms and model systems. J Mol Cell Cardiol. 2016 May; 94:22-31. PMID: 26996756.
        View in: PubMed
      4. Liang Y, Sheikh F. Scaffold Proteins Regulating Extracellular Regulated Kinase Function in Cardiac Hypertrophy and Disease. Front Pharmacol. 2016; 7:37. PMID: 26973524.
        View in: PubMed
      5. Ma X, Qu X, Zhu W, Li YS, Yuan S, Zhang H, Liu J, Wang P, Lai CS, Zanella F, Feng GS, Sheikh F, Chien S, Chen S. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2206-11. PMID: 26858399.
        View in: PubMed
      6. Zanella F, Sheikh F. Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization of Cardiac Cells. Methods Mol Biol. 2016; 1353:147-62. PMID: 25520292.
        View in: PubMed
      7. Sheikh F, Lyon RC, Chen J. Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease. Gene. 2015 Sep 10; 569(1):14-20. PMID: 26074085.
        View in: PubMed
      8. Mastrototaro G, Liang X, Li X, Carullo P, Piroddi N, Tesi C, Gu Y, Dalton ND, Peterson KL, Poggesi C, Sheikh F, Chen J, Bang ML. Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers. Cardiovasc Res. 2015 Jul 15; 107(2):216-25. PMID: 25987543.
        View in: PubMed
      9. Hribar KC, Finlay D, Ma X, Qu X, Ondeck MG, Chung PH, Zanella F, Engler AJ, Sheikh F, Vuori K, Chen SC. Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture. Lab Chip. 2015 Jun 7; 15(11):2412-8. PMID: 25900329.
        View in: PubMed
      10. Sheikh F, Zanesco A. Women in science. Life Sci. 2015 Mar 15; 125:1. PMID: 25749606.
        View in: PubMed
      11. Pellman J, Sheikh F. Atrial fibrillation: mechanisms, therapeutics, and future directions. Compr Physiol. 2015 Mar 1; 5(2):649-65. PMID: 25880508.
        View in: PubMed
      12. Pellman J, Sheikh F. A new mechanism links preamyloid oligomer formation in the myocyte stress response associated with atrial fibrillation. J Mol Cell Cardiol. 2015 Mar; 80:110-3. PMID: 25541246.
        View in: PubMed
      13. Mezzano V, Pellman J, Sheikh F. Cell junctions in the specialized conduction system of the heart. Cell Commun Adhes. 2014 Jun; 21(3):149-59. PMID: 24738884.
        View in: PubMed
      14. Lyon RC, Mezzano V, Wright AT, Pfeiffer E, Chuang J, Banares K, Castaneda A, Ouyang K, Cui L, Contu R, Gu Y, Evans SM, Omens JH, Peterson KL, McCulloch AD, Sheikh F. Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Hum Mol Genet. 2014 Mar 1; 23(5):1134-50. PMID: 24108106.
        View in: PubMed
      15. Zanella F, Lyon RC, Sheikh F. Modeling heart disease in a dish: From somatic cells to disease-relevant cardiomyocytes. Trends Cardiovasc Med. 2014 Jan; 24(1):32-44. PMID: 24054750.
        View in: PubMed
      16. Lin C, Guo X, Lange S, Liu J, Ouyang K, Yin X, Jiang L, Cai Y, Mu Y, Sheikh F, Ye S, Chen J, Ke Y, Cheng H. Cypher/ZASP is a novel A-kinase anchoring protein. J Biol Chem. 2013 Oct 11; 288(41):29403-13. PMID: 23996002.
        View in: PubMed
      17. Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J. Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Hum Mol Genet. 2014 Jan 1; 23(1):209-25. PMID: 23975679.
        View in: PubMed
      18. Sheikh F, Lyon RC, Chen J. Getting the skinny on thick filament regulation in cardiac muscle biology and disease. Trends Cardiovasc Med. 2014 May; 24(4):133-41. PMID: 23968570.
        View in: PubMed
      19. Lyon RC, Lange S, Sheikh F. Breaking down protein degradation mechanisms in cardiac muscle. Trends Mol Med. 2013 Apr; 19(4):239-49. PMID: 23453282.
        View in: PubMed
      20. Rao N, Evans S, Stewart D, Spencer KH, Sheikh F, Hui EE, Christman KL. Fibroblasts influence muscle progenitor differentiation and alignment in contact independent and dependent manners in organized co-culture devices. Biomed Microdevices. 2013 Feb; 15(1):161-9. PMID: 22983793.
        View in: PubMed
      21. Cooley N, Ouyang K, McMullen JR, Kiriazis H, Sheikh F, Wu W, Mu Y, Du XJ, Chen J, Woodcock EA. No contribution of IP3-R(2) to disease phenotype in models of dilated cardiomyopathy or pressure overload hypertrophy. Circ Heart Fail. 2013 Mar; 6(2):318-25. PMID: 23258573.
        View in: PubMed
      22. Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem. 2012 Aug 24; 287(35):29273-84. PMID: 22778266.
        View in: PubMed
      23. DeQuach JA, Lin JE, Cam C, Hu D, Salvatore MA, Sheikh F, Christman KL. Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model. Eur Cell Mater. 2012; 23:400-12; discussion 412. PMID: 22665162.
        View in: PubMed
      24. Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest. 2012 Apr 2; 122(4):1209-21. PMID: 22426213.
        View in: PubMed
      25. Mezzano V, Sheikh F. Cell-cell junction remodeling in the heart: possible role in cardiac conduction system function and arrhythmias? Life Sci. 2012 Feb 27; 90(9-10):313-21. PMID: 22227473.
        View in: PubMed
      26. Cheng H, Zheng M, Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui L, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans SM, Knowlton KU, Sheikh F, Chen J. Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet. 2011 May 1; 20(9):1751-62. PMID: 21303826.
        View in: PubMed
      27. DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL. Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS One. 2010; 5(9):e13039. PMID: 20885963.
        View in: PubMed
      28. Lu SY, Jin Y, Li X, Sheppard P, Bock ME, Sheikh F, Duckworth ML, Cattini PA. Embryonic survival and severity of cardiac and craniofacial defects are affected by genetic background in fibroblast growth factor-16 null mice. DNA Cell Biol. 2010 Aug; 29(8):407-15. PMID: 20618076.
        View in: PubMed
      29. Seeger TS, Frank D, Rohr C, Will R, Just S, Grund C, Lyon R, Luedde M, Koegl M, Sheikh F, Rottbauer W, Franke WW, Katus HA, Olson EN, Frey N. Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo. Circ Res. 2010 Mar 19; 106(5):880-90. PMID: 20093627.
        View in: PubMed
      30. Pellman J, Lyon RC, Sheikh F. Extracellular matrix remodeling in atrial fibrosis: mechanisms and implications in atrial fibrillation. J Mol Cell Cardiol. 2010 Mar; 48(3):461-7. PMID: 19751740.
        View in: PubMed
      31. Sheikh F, Ross RS, Chen J. Cell-cell connection to cardiac disease. Trends Cardiovasc Med. 2009 Aug; 19(6):182-90. PMID: 20211433.
        View in: PubMed
      32. Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, Feng GS. Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol Cell Biol. 2009 Jan; 29(2):378-88. PMID: 19001090.
        View in: PubMed
      33. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. PMID: 19033658.
        View in: PubMed
      34. Sheikh F, Bang ML, Lange S, Chen J. "Z"eroing in on the role of Cypher in striated muscle function, signaling, and human disease. Trends Cardiovasc Med. 2007 Nov; 17(8):258-62. PMID: 18021935.
        View in: PubMed
      35. Sheikh F, Chen Y, Chen Y, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton ND, Yajima T, Lu Y, Knowlton KU, Peterson KL, Perriard JC, Chen J. alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation. 2006 Sep 5; 114(10):1046-55. PMID: 16923756.
        View in: PubMed
      36. Li X, Zima AV, Sheikh F, Blatter LA, Chen J. Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice. Circ Res. 2005 Jun 24; 96(12):1274-81. PMID: 15933266.
        View in: PubMed
      37. Sheikh F, Hirst CJ, Jin Y, Bock ME, Fandrich RR, Nickel BE, Doble BW, Kardami E, Cattini PA. Inhibition of TGFbeta signaling potentiates the FGF-2-induced stimulation of cardiomyocyte DNA synthesis. Cardiovasc Res. 2004 Dec 1; 64(3):516-25. PMID: 15537505.
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      38. Kardami E, Jiang ZS, Jimenez SK, Hirst CJ, Sheikh F, Zahradka P, Cattini PA. Fibroblast growth factor 2 isoforms and cardiac hypertrophy. Cardiovasc Res. 2004 Aug 15; 63(3):458-66. PMID: 15276471.
        View in: PubMed
      39. Jimenez SK, Sheikh F, Jin Y, Detillieux KA, Dhaliwal J, Kardami E, Cattini PA. Transcriptional regulation of FGF-2 gene expression in cardiac myocytes. Cardiovasc Res. 2004 Jun 1; 62(3):548-57. PMID: 15158147.
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      40. Huang C, Sheikh F, Hollander M, Cai C, Becker D, Chu PH, Evans S, Chen J. Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis. Development. 2003 Dec; 130(24):6111-9. PMID: 14573518.
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      41. Detillieux KA, Sheikh F, Kardami E, Cattini PA. Biological activities of fibroblast growth factor-2 in the adult myocardium. Cardiovasc Res. 2003 Jan; 57(1):8-19. PMID: 12504809.
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      42. Huang C, Zhou Q, Liang P, Hollander MS, Sheikh F, Li X, Greaser M, Shelton GD, Evans S, Chen J. Characterization and in vivo functional analysis of splice variants of cypher. J Biol Chem. 2003 Feb 28; 278(9):7360-5. PMID: 12499364.
        View in: PubMed
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