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Robert Parmer

Title(s)Senate Emeritus, Medicine
SchoolHealth Sciences
Phone858-552-8585
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    Collapse Research 
    Collapse Research Activities and Funding
    A Novel Plasminogen Receptor Promotes Adipose Function and Metabolic Homeostasis
    NIH/NHLBI R01HL149511May 1, 2019 - Apr 30, 2023
    Role: Co-Principal Investigator
    Regulation of Renal Injury and Fibrosis by the Plasminogen Receptor, Plg-RKT
    VA I01BX003933Apr 1, 2018 - Mar 31, 2022
    Role: Principal Investigator
    Cell Surface Plasminogen Activation and Hypertension
    VA I01BX002026Apr 1, 2013 - Mar 31, 2017
    Role: Principal Investigator
    PROCESSING OF CHROMOGRANIN A BY THE FIBRINOLYTIC SYSTEM
    NIH/NHLBI R01HL050398Sep 1, 1994 - Jun 30, 2005
    Role: Principal Investigator
    AUTONOMIC AND RENAL PHENOTYPES IN BLACK PEDIGREES
    NIH/NHLBI R01HL050174Sep 30, 1992 - Sep 29, 1995
    Role: Principal Investigator
    CHROMOGRANIN
    NIH/NHLBI K11HL001416Jul 1, 1984 - Jun 30, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Vago JP, Sugimoto MA, Lima KM, Negreiros-Lima GL, Baik N, Teixeira MM, Perretti M, Parmer RJ, Miles LA, Sousa LP. Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes. Front Immunol. 2019; 10:1458. PMID: 31316511.
      View in: PubMed
    2. Thaler B, Baik N, Hohensinner PJ, Baumgartner J, Panzenböck A, Stojkovic S, Demyanets S, Huk I, Rega-Kaun G, Kaun C, Prager M, Fischer MB, Huber K, Speidl WS, Parmer RJ, Miles LA, Wojta J. Differential expression of Plg-RKT and its effects on migration of proinflammatory monocyte and macrophage subsets. Blood. 2019 Aug 08; 134(6):561-567. PMID: 31221672.
      View in: PubMed
    3. Miles LA, Parmer RJ. tPA and anger management for macrophages. Blood. 2017 09 14; 130(11):1280-1281. PMID: 28912293.
      View in: PubMed
    4. Briens A, Bardou I, Lebas H, Miles LA, Parmer RJ, Vivien D, Docagne F. Astrocytes regulate the balance between plasminogen activation and plasmin clearance via cell-surface actin. Cell Discov. 2017; 3:17001. PMID: 28417010.
      View in: PubMed
    5. Miles LA, Parmer RJ. Angry macrophages patrol for fibrin. Blood. 2016 Mar 03; 127(9):1079-80. PMID: 26941388.
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    6. Miles LA, Parmer RJ. Setting the table for macrophages. Blood. 2014 Jul 31; 124(5):665-6. PMID: 25082858.
      View in: PubMed
    7. Miles LA, Lighvani S, Baik N, Parmer CM, Khaldoyanidi S, Mueller BM, Parmer RJ. New insights into the role of Plg-RKT in macrophage recruitment. Int Rev Cell Mol Biol. 2014; 309:259-302. PMID: 24529725.
      View in: PubMed
    8. Miles LA, Parmer RJ. Plasminogen receptors: the first quarter century. Semin Thromb Hemost. 2013 Jun; 39(4):329-37. PMID: 23532575.
      View in: PubMed
    9. Miles LA, Plow EF, Waisman DM, Parmer RJ. Plasminogen receptors. J Biomed Biotechnol. 2012; 2012:130735. PMID: 23226936.
      View in: PubMed
    10. Bai H, Nangia S, Parmer RJ. The plasminogen activation system and the regulation of catecholaminergic function. J Biomed Biotechnol. 2012; 2012:721657. PMID: 23097598.
      View in: PubMed
    11. Miles LA, Lighvani S, Baik N, Andronicos NM, Chen EI, Parmer CM, Khaldoyanidi S, Diggs JE, Kiosses WB, Kamps MP, Yates JR, Parmer RJ. The plasminogen receptor, Plg-R(KT), and macrophage function. J Biomed Biotechnol. 2012; 2012:250464. PMID: 23125524.
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    12. Félez J, Jardí M, Fàbregas P, Parmer RJ, Miles LA. Monoclonal antibodies against receptor-induced binding sites detect cell-bound plasminogen in blood. Blood. 2012 Jul 19; 120(3):678-81. PMID: 22649107.
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    13. Lighvani S, Baik N, Diggs JE, Khaldoyanidi S, Parmer RJ, Miles LA. Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT. Blood. 2011 Nov 17; 118(20):5622-30. PMID: 21940822.
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    14. Bai H, Baik N, Kiosses WB, Krajewski S, Miles LA, Parmer RJ. The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release. J Biol Chem. 2011 Sep 23; 286(38):33125-33. PMID: 21795689.
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    15. Han J, Baik N, Kim KH, Yang JM, Han GW, Gong Y, Jardí M, Castellino FJ, Felez J, Parmer RJ, Miles LA. Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen. Blood. 2011 Aug 11; 118(6):1653-62. PMID: 21680799.
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    16. Jiang Q, Gingles NA, Olivier MA, Miles LA, Parmer RJ. The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles. Blood. 2011 Jun 30; 117(26):7155-63. PMID: 21596853.
      View in: PubMed
    17. Miles LA, Parmer RJ. S100A10: a complex inflammatory role. Blood. 2010 Aug 19; 116(7):1022-4. PMID: 20724548.
      View in: PubMed
    18. Miles LA, Parmer RJ. PAI-1: cardiac friend or foe? Blood. 2010 Mar 11; 115(10):1862-3. PMID: 20223930.
      View in: PubMed
    19. Andronicos NM, Chen EI, Baik N, Bai H, Parmer CM, Kiosses WB, Kamps MP, Yates JR, Parmer RJ, Miles LA. Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation. Blood. 2010 Feb 18; 115(7):1319-30. PMID: 19897580.
      View in: PubMed
    20. Gutiérrez-Fernández A, Gingles NA, Bai H, Castellino FJ, Parmer RJ, Miles LA. Plasminogen enhances neuritogenesis on laminin-1. J Neurosci. 2009 Oct 07; 29(40):12393-400. PMID: 19812315.
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    21. Miles LA, Andronicos NM, Baik N, Parmer RJ. Cell-surface actin binds plasminogen and modulates neurotransmitter release from catecholaminergic cells. J Neurosci. 2006 Dec 13; 26(50):13017-24. PMID: 17167091.
      View in: PubMed
    22. Etzel JP, Rana BK, Wen G, Parmer RJ, Schork NJ, O'Connor DT, Insel PA. Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. Hypertension. 2005 Jun; 45(6):1207-13. PMID: 15920038.
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    23. Miles LA, Hawley SB, Baik N, Andronicos NM, Castellino FJ, Parmer RJ. Plasminogen receptors: the sine qua non of cell surface plasminogen activation. Front Biosci. 2005 May 01; 10:1754-62. PMID: 15769664.
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    24. Le Corre P, Parmer RJ, Kailasam MT, Kennedy BP, Skaar TP, Ho H, Leverge R, Smith DW, Ziegler MG, Insel PA, Schork NJ, Flockhart DA, O'connor DT. Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism. Clin Pharmacol Ther. 2004 Aug; 76(2):139-53. PMID: 15289791.
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    25. Lee JC, Taylor CV, Gaucher SP, Toneff T, Taupenot L, Yasothornsrikul S, Mahata SK, Sei C, Parmer RJ, Neveu JM, Lane WS, Gibson BW, O'Connor DT, Hook VY. Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells. Biochemistry. 2003 Jun 17; 42(23):6938-46. PMID: 12795588.
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    26. Wong CM, O'Connor DT, Martinez JA, Kailasam MT, Parmer RJ. Diminished renal kallikrein responses to mineralocorticoid stimulation in African Americans: determinants of an intermediate phenotype for hypertension. Am J Hypertens. 2003 Apr; 16(4):281-9. PMID: 12670744.
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    27. Taupenot L, Harper KL, Mahapatra NR, Parmer RJ, Mahata SK, O'Connor DT. Identification of a novel sorting determinant for the regulated pathway in the secretory protein chromogranin A. J Cell Sci. 2002 Dec 15; 115(Pt 24):4827-41. PMID: 12432071.
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    28. Jiang Q, Yasothornsrikul S, Taupenot L, Miles LA, Parmer RJ. The local chromaffin cell plasminogen/plasmin system and the regulation of catecholamine secretion. Ann N Y Acad Sci. 2002 Oct; 971:445-9. PMID: 12438162.
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    29. Miles LA, Hawley SB, Parmer RJ. Chromaffin cell plasminogen receptors. Ann N Y Acad Sci. 2002 Oct; 971:454-9. PMID: 12438164.
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    30. O'Connor DT, Kailasam MT, Kennedy BP, Ziegler MG, Yanaihara N, Parmer RJ. The catecholamine release-inhibitory "catestatin" region of chromogranin a: early decline in humans at genetic risk of hypertension. Ann N Y Acad Sci. 2002 Oct; 971:533-5. PMID: 12438176.
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    31. Taupenot L, Harper KL, Mahapatra NR, Parmer RJ, O'Connor DT. Intracellular protein trafficking into catecholamine storage vesicles: novel chimeric photoproteins visualized by deconvolution fluorescence microscopy. Ann N Y Acad Sci. 2002 Oct; 971:262-5. PMID: 12438129.
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    32. Parmer RJ, Zinder O. Catecholaminergic pathways, chromaffin cells, and human disease. Ann N Y Acad Sci. 2002 Oct; 971:497-505. PMID: 12438170.
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    33. Bannach FG, Gutierrez A, Fowler BJ, Bugge TH, Degen JL, Parmer RJ, Miles LA. Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression. J Biol Chem. 2002 Oct 11; 277(41):38579-88. PMID: 12149246.
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    34. O'Connor DT, Kailasam MT, Kennedy BP, Ziegler MG, Yanaihara N, Parmer RJ. Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension. J Hypertens. 2002 Jul; 20(7):1335-45. PMID: 12131530.
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    35. Zhang L, Seiffert D, Fowler BJ, Jenkins GR, Thinnes TC, Loskutoff DJ, Parmer RJ, Miles LA. Plasminogen has a broad extrahepatic distribution. Thromb Haemost. 2002 Mar; 87(3):493-501. PMID: 11916082.
      View in: PubMed
    36. Parmer RJ, Mahata M, Gong Y, Mahata SK, Jiang Q, O'Connor DT, Xi XP, Miles LA. Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion. J Clin Invest. 2000 Oct; 106(7):907-15. PMID: 11018079.
      View in: PubMed
    37. Parmer RJ, Mahata M, Mahata S, Sebald MT, O'Connor DT, Miles LA. Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway. Catecholamine storage vesicles as a reservoir for the rapid release of t-PA. J Biol Chem. 1997 Jan 17; 272(3):1976-82. PMID: 8999889.
      View in: PubMed
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