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Plasminogen and plasmin induce specialized proresolving mediators and promote efferocytosis via 5-lipoxygenase. J Thromb Haemost. 2025 Jun; 23(6):1988-1995.
Perucci LO, Carneiro FS, Souza JC, Grossi LC, Souza JAM, Zaidan I, Cardoso C, Lara ES, Felix FB, Baik N, Tavares LP, Soriani FM, Teixeira MM, Parmer RJ, Miles LA, Sousa LP. PMID: 40147777.
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Translation:
AnimalsCells
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Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT. Cell Rep. 2024 03 26; 43(3):113881.
Bareja A, Lee DE, Ho T, Waitt G, McKay LH, Hannou SA, Orenduff MC, McGreevy KM, Binder A, Ryan CP, Soderblom EJ, Belsky DW, Ferrucci L, Das JK, Banskota N, Kraus VB, Huebner JL, Kraus WE, Huffman KM, Baht GS, Horvath S, Parmer RJ, Miles LA, White JP. PMID: 38442019; PMCID: PMC11075744.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Overexpression of Plg-RKT protects against adipose dysfunction and dysregulation of glucose homeostasis in diet-induced obese mice. Adipocyte. 2023 12; 12(1):2252729.
Miles LA, Bai H, Chakrabarty S, Baik N, Zhang Y, Parmer RJ, Samad F. PMID: 37642146; PMCID: PMC10481882.
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Translation:
Animals
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Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression. Mol Oncol. 2024 Jan; 18(1):113-135.
Chowdhury NN, Yang Y, Dutta A, Luo M, Wei Z, Abrahams SR, Revenko AS, Shah F, Miles LA, Parmer RJ, de Laat B, Wolberg AS, Luyendyk JP, Fishel ML, Flick MJ. PMID: 37971174; PMCID: PMC10766200.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Plasmin and plasminogen prevent sepsis severity by reducing neutrophil extracellular traps and systemic inflammation. JCI Insight. 2023 04 24; 8(8).
Vago JP, Zaidan I, Perucci LO, Brito LF, Teixeira LC, Silva CMS, Miranda TC, Melo EM, Bruno AS, Queiroz-Junior CM, Sugimoto MA, Tavares LP, Grossi LC, Borges IN, Schneider AH, Baik N, Schneider AH, Talvani A, Ferreira RG, Alves-Filho JC, Nobre V, Teixeira MM, Parmer RJ, Miles LA, Sousa LP. PMID: 36917195; PMCID: PMC10243804.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Plg-RKT Expression in Human Breast Cancer Tissues. Biomolecules. 2022 03 26; 12(4).
Miles LA, Krajewski S, Baik N, Parmer RJ, Mueller BM. PMID: 35454092; PMCID: PMC9028288.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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The plasminogen receptor Plg-RKT regulates adipose function and metabolic homeostasis. J Thromb Haemost. 2022 03; 20(3):742-754.
Samad F, Bai H, Baik N, Haider P, Zhang Y, Rega-Kaun G, Kaun C, Prager M, Wojta J, Bui Q, Chakrabarty S, Wang J, Parmer RJ, Miles LA. PMID: 34897983; PMCID: PMC8885904.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Plasminogen Receptors and Fibrinolysis. Int J Mol Sci. 2021 Feb 08; 22(4).
Miles LA, Ny L, Wilczynska M, Shen Y, Ny T, Parmer RJ. PMID: 33567773; PMCID: PMC7914795.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimals
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Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets. Blood. 2021 01 14; 137(2):248-257.
Whyte CS, Morrow GB, Baik N, Booth NA, Jalal MM, Parmer RJ, Miles LA, Mutch NJ. PMID: 32842150; PMCID: PMC7820873.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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The plasminogen receptor, Plg-RKT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice. Cell Death Dis. 2020 12 12; 11(12):1054.
Ny L, Parmer RJ, Shen Y, Holmberg S, Baik N, Bäckman A, Broden J, Wilczynska M, Ny T, Miles LA. PMID: 33311441; PMCID: PMC7733490.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Functions of the plasminogen receptor Plg-RKT. J Thromb Haemost. 2020 10; 18(10):2468-2481.
Miles LA, Vago JP, Sousa LP, Parmer RJ. PMID: 32662180; PMCID: PMC7722214.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Neuroendocrine Targeting of Tissue Plasminogen Activator (t-PA). J Neurol Disord Stroke. 2020; 7(1).
Parmer RJ, Gong Y, Yoo SH, Miles LA. PMID: 32549050; PMCID: PMC7297194.
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PubMed Mentions:
2
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Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes. Front Immunol. 2019; 10:1458.
Vago JP, Sugimoto MA, Lima KM, Negreiros-Lima GL, Baik N, Teixeira MM, Perretti M, Parmer RJ, Miles LA, Sousa LP. PMID: 31316511; PMCID: PMC6611080.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Differential expression of Plg-RKT and its effects on migration of proinflammatory monocyte and macrophage subsets. Blood. 2019 08 08; 134(6):561-567.
Thaler B, Baik N, Hohensinner PJ, Baumgartner J, Panzenböck A, Stojkovic S, Demyanets S, Huk I, Rega-Kaun G, Kaun C, Prager M, Fischer MB, Huber K, Speidl WS, Parmer RJ, Miles LA, Wojta J. PMID: 31221672; PMCID: PMC6688429.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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tPA and anger management for macrophages. Blood. 2017 09 14; 130(11):1280-1281.
Miles LA, Parmer RJ. PMID: 28912293; PMCID: PMC5600143.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Astrocytes regulate the balance between plasminogen activation and plasmin clearance via cell-surface actin. Cell Discov. 2017; 3:17001.
Briens A, Bardou I, Lebas H, Miles LA, Parmer RJ, Vivien D, Docagne F. PMID: 28417010; PMCID: PMC5318850.
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PubMed Mentions:
18
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Angry macrophages patrol for fibrin. Blood. 2016 Mar 03; 127(9):1079-80.
Miles LA, Parmer RJ. PMID: 26941388; PMCID: PMC4778160.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Setting the table for macrophages. Blood. 2014 Jul 31; 124(5):665-6.
Miles LA, Parmer RJ. PMID: 25082858; PMCID: PMC4118476.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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New insights into the role of Plg-RKT in macrophage recruitment. Int Rev Cell Mol Biol. 2014; 309:259-302.
Miles LA, Lighvani S, Baik N, Parmer CM, Khaldoyanidi S, Mueller BM, Parmer RJ. PMID: 24529725; PMCID: PMC4060795.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Plasminogen receptors: the first quarter century. Semin Thromb Hemost. 2013 Jun; 39(4):329-37.
Miles LA, Parmer RJ. PMID: 23532575; PMCID: PMC3938387.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Plasminogen receptors. J Biomed Biotechnol. 2012; 2012:130735.
Miles LA, Plow EF, Waisman DM, Parmer RJ. PMID: 23226936; PMCID: PMC3511834.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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The plasminogen activation system and the regulation of catecholaminergic function. J Biomed Biotechnol. 2012; 2012:721657.
Bai H, Nangia S, Parmer RJ. PMID: 23097598; PMCID: PMC3477892.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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The plasminogen receptor, Plg-R(KT), and macrophage function. J Biomed Biotechnol. 2012; 2012:250464.
Miles LA, Lighvani S, Baik N, Andronicos NM, Chen EI, Parmer CM, Khaldoyanidi S, Diggs JE, Kiosses WB, Kamps MP, Yates JR, Parmer RJ. PMID: 23125524; PMCID: PMC3484331.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Monoclonal antibodies against receptor-induced binding sites detect cell-bound plasminogen in blood. Blood. 2012 Jul 19; 120(3):678-81.
Félez J, Jardí M, Fàbregas P, Parmer RJ, Miles LA. PMID: 22649107; PMCID: PMC3401219.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT. Blood. 2011 Nov 17; 118(20):5622-30.
Lighvani S, Baik N, Diggs JE, Khaldoyanidi S, Parmer RJ, Miles LA. PMID: 21940822; PMCID: PMC3217361.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release. J Biol Chem. 2011 Sep 23; 286(38):33125-33.
Bai H, Baik N, Kiosses WB, Krajewski S, Miles LA, Parmer RJ. PMID: 21795689; PMCID: PMC3190921.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen. Blood. 2011 Aug 11; 118(6):1653-62.
Han J, Baik N, Kim KH, Yang JM, Han GW, Gong Y, Jardí M, Castellino FJ, Felez J, Parmer RJ, Miles LA. PMID: 21680799; PMCID: PMC3156051.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles. Blood. 2011 Jun 30; 117(26):7155-63.
Jiang Q, Gingles NA, Olivier MA, Miles LA, Parmer RJ. PMID: 21596853; PMCID: PMC3143556.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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S100A10: a complex inflammatory role. Blood. 2010 Aug 19; 116(7):1022-4.
Miles LA, Parmer RJ. PMID: 20724548.
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5 Fields:
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PAI-1: cardiac friend or foe? Blood. 2010 Mar 11; 115(10):1862-3.
Miles LA, Parmer RJ. PMID: 20223930.
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PubMed Mentions:
5 Fields:
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Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation. Blood. 2010 Feb 18; 115(7):1319-30.
Andronicos NM, Chen EI, Baik N, Bai H, Parmer CM, Kiosses WB, Kamps MP, Yates JR, Parmer RJ, Miles LA. PMID: 19897580; PMCID: PMC2826757.
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PubMed Mentions:
76 Fields:
Translation:
HumansCells
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Plasminogen enhances neuritogenesis on laminin-1. J Neurosci. 2009 Oct 07; 29(40):12393-400.
Gutiérrez-Fernández A, Gingles NA, Bai H, Castellino FJ, Parmer RJ, Miles LA. PMID: 19812315; PMCID: PMC2789650.
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PubMed Mentions:
16 Fields:
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Cell-surface actin binds plasminogen and modulates neurotransmitter release from catecholaminergic cells. J Neurosci. 2006 Dec 13; 26(50):13017-24.
Miles LA, Andronicos NM, Baik N, Parmer RJ. PMID: 17167091; PMCID: PMC6674961.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. Hypertension. 2005 Jun; 45(6):1207-13.
Etzel JP, Rana BK, Wen G, Parmer RJ, Schork NJ, O'Connor DT, Insel PA. PMID: 15920038.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Plasminogen receptors: the sine qua non of cell surface plasminogen activation. Front Biosci. 2005 May 01; 10:1754-62.
Miles LA, Hawley SB, Baik N, Andronicos NM, Castellino FJ, Parmer RJ. PMID: 15769664.
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PubMed Mentions:
50 Fields:
Translation:
Animals
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Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism. Clin Pharmacol Ther. 2004 Aug; 76(2):139-53.
Le Corre P, Parmer RJ, Kailasam MT, Kennedy BP, Skaar TP, Ho H, Leverge R, Smith DW, Ziegler MG, Insel PA, Schork NJ, Flockhart DA, O'connor DT. PMID: 15289791.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells. Biochemistry. 2003 Jun 17; 42(23):6938-46.
Lee JC, Taylor CV, Gaucher SP, Toneff T, Taupenot L, Yasothornsrikul S, Mahata SK, Sei C, Parmer RJ, Neveu JM, Lane WS, Gibson BW, O'Connor DT, Hook VY. PMID: 12795588.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Diminished renal kallikrein responses to mineralocorticoid stimulation in African Americans: determinants of an intermediate phenotype for hypertension. Am J Hypertens. 2003 Apr; 16(4):281-9.
Wong CM, O'Connor DT, Martinez JA, Kailasam MT, Parmer RJ. PMID: 12670744.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Identification of a novel sorting determinant for the regulated pathway in the secretory protein chromogranin A. J Cell Sci. 2002 Dec 15; 115(Pt 24):4827-41.
Taupenot L, Harper KL, Mahapatra NR, Parmer RJ, Mahata SK, O'Connor DT. PMID: 12432071.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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The local chromaffin cell plasminogen/plasmin system and the regulation of catecholamine secretion. Ann N Y Acad Sci. 2002 Oct; 971:445-9.
Jiang Q, Yasothornsrikul S, Taupenot L, Miles LA, Parmer RJ. PMID: 12438162.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Intracellular protein trafficking into catecholamine storage vesicles: novel chimeric photoproteins visualized by deconvolution fluorescence microscopy. Ann N Y Acad Sci. 2002 Oct; 971:262-5.
Taupenot L, Harper KL, Mahapatra NR, Parmer RJ, O'Connor DT. PMID: 12438129.
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Translation:
HumansAnimalsCells
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Catecholaminergic pathways, chromaffin cells, and human disease. Ann N Y Acad Sci. 2002 Oct; 971:497-505.
Parmer RJ, Zinder O. PMID: 12438170.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Chromaffin cell plasminogen receptors. Ann N Y Acad Sci. 2002 Oct; 971:454-9.
Miles LA, Hawley SB, Parmer RJ. PMID: 12438164.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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The catecholamine release-inhibitory "catestatin" region of chromogranin a: early decline in humans at genetic risk of hypertension. Ann N Y Acad Sci. 2002 Oct; 971:533-5.
O'Connor DT, Kailasam MT, Kennedy BP, Ziegler MG, Yanaihara N, Parmer RJ. PMID: 12438176.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression. J Biol Chem. 2002 Oct 11; 277(41):38579-88.
Bannach FG, Gutierrez A, Fowler BJ, Bugge TH, Degen JL, Parmer RJ, Miles LA. PMID: 12149246.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension. J Hypertens. 2002 Jul; 20(7):1335-45.
O'Connor DT, Kailasam MT, Kennedy BP, Ziegler MG, Yanaihara N, Parmer RJ. PMID: 12131530.
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PubMed Mentions:
83 Fields:
Translation:
HumansCTClinical Trials
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Plasminogen has a broad extrahepatic distribution. Thromb Haemost. 2002 Mar; 87(3):493-501.
Zhang L, Seiffert D, Fowler BJ, Jenkins GR, Thinnes TC, Loskutoff DJ, Parmer RJ, Miles LA. PMID: 11916082.
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PubMed Mentions:
44 Fields:
Translation:
Animals
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Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion. J Clin Invest. 2000 Oct; 106(7):907-15.
Parmer RJ, Mahata M, Gong Y, Mahata SK, Jiang Q, O'Connor DT, Xi XP, Miles LA. PMID: 11018079; PMCID: PMC381423.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway. Catecholamine storage vesicles as a reservoir for the rapid release of t-PA. J Biol Chem. 1997 Jan 17; 272(3):1976-82.
Parmer RJ, Mahata M, Mahata S, Sebald MT, O'Connor DT, Miles LA. PMID: 8999889.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells