Bruce Hamilton

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    UC San DiegoBA1986Molecular Biology
    CaltechPhD1993Genetics
    Whitehead Institutepostdoctoral1998Genetics
    Collapse Awards and Honors
    Office of National Drug Control Policy2001Certificate of Appreciation
    Pew Trusts1999  - 2003Pew Scholar in the Biomedical Sciences
    March of Dimes1999  - 2001Basil O’Connor Starter Scholars Award
    Helen Hay Whitney Foundation1993  - 1996Postdoctoral Fellowship

    Collapse Overview 
    Collapse Overview
    Dr. Hamilton is Professor of Cellular and Molecular Medicine, Director of the UCSD Genetics Training Program, Training Area Leader for Genetics and Genomics in the Biomedical Sciences Graduate Program, and a co-founder and Associate Director of the UCSD Institute for Genomic Medicine. He graduated Revelle College at UCSD in 1986. He completed his PhD at Caltech, using Drosophila genetics and developing new genetic methods to understand development of the nervous system, including isolation of the first receptor tyrosine phosphatase mutation. As a postdoctoral fellow at the Whitehead Institute, he extended genetic and genomic approaches to positional cloning of genes in human disease and experimental mouse models, including the classical mutations staggerer and vibrator. In 1998, Dr. Hamilton returned to UCSD as Assistant Professor in the Division of Genetics. His laboratory is interested in genetic control of neural development, modifier gene networks, and genetic variation in neural control of blood pressure. His work has been funded by several NIH Institutes, the March of Dimes and the Pew Scholars Program in Biomedical Sciences.

    Collapse Research 
    Collapse Research Activities and Funding
    UC San Diego Genetics Training Program
    NIH T32GM145427Jul 1, 2022 - Jun 30, 2027
    Role: Principal Investigator
    Zfp423 Mechanisms in Joubert Syndrome and Related Disorders
    NIH R01NS097534Feb 1, 2017 - May 31, 2027
    Role: Principal Investigator
    Mouse models of ZNF804A
    NIH R21MH109960Apr 15, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Synthetic Lethal Modifier of a New Ciliopathy Gene
    NIH R01GM102958Jul 27, 2012 - Apr 30, 2016
    Role: Principal Investigator
    Genetic Analysis of Neural Stem Cells
    NIH R01NS060109Dec 15, 2007 - Nov 30, 2013
    Role: Principal Investigator
    Genetic Mechanisms in Cerebellum Malformations
    NIH R01NS054871May 7, 2007 - Mar 31, 2013
    Role: Principal Investigator
    Sympathetic Neuroeffector Junctions &Blood Pressure
    NIH P01HL058120Jun 1, 1999 - May 31, 2012
    Role: Co-Investigator
    Genetic Modifier Activity and Network Properties of Nxf1
    NIH R01GM086912Dec 1, 1998 - Dec 31, 2020
    Role: Principal Investigator
    GENETIC DISSECTION OF A NEURODEGENERATION PATHWAY
    NIH R01MH059207Dec 1, 1998 - Nov 30, 2009
    Role: Principal Investigator
    Training Program in Basic and Clinical Genetics
    NIH T32GM008666Jul 1, 1998 - Jun 30, 2022
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ankfn1-mutant vestibular defects require loss of both ancestral and derived paralogs for penetrance in zebrafish. G3 (Bethesda). 2022 03 04; 12(3). Ross KD, Ren J, Zhang R, Chi NC, Hamilton BA. PMID: 35100349; PMCID: PMC9210315.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Strain-Dependent Modifier Genes Determine Survival in Zfp423 Mice. G3 (Bethesda). 2020 11 05; 10(11):4241-4247. Alcaraz WA, Liu Z, Valdes P, Chen E, Valdovino Gonzalez AG, Wade S, Wong C, Kim E, Chen HM, Ponn A, Concepcion D, Hamilton BA. PMID: 32967895; PMCID: PMC7642944.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    3. ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities. PLoS Genet. 2020 09; 16(9):e1009017. Deshpande O, Lara RZ, Zhang OR, Concepcion D, Hamilton BA. PMID: 32925911; PMCID: PMC7515201.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    4. The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina. Aging Cell. 2020 02; 19(2):e13100. Chen D, Chao DL, Rocha L, Kolar M, Nguyen Huu VA, Krawczyk M, Dasyani M, Wang T, Jafari M, Jabari M, Ross KD, Saghatelian A, Hamilton BA, Zhang K, Skowronska-Krawczyk D. PMID: 31943697; PMCID: PMC6996962.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    5. TBR2 antagonizes retinoic acid dependent neuronal differentiation by repressing Zfp423 during corticogenesis. Dev Biol. 2018 02 15; 434(2):231-248. Massimino L, Flores-Garcia L, Di Stefano B, Colasante G, Icoresi-Mazzeo C, Zaghi M, Hamilton BA, Sessa A. PMID: 29305158; PMCID: PMC7032051.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    6. Regeneration of fat cells from myofibroblasts during wound healing. Science. 2017 02 17; 355(6326):748-752. Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G. PMID: 28059714; PMCID: PMC5464786.
      View in: PubMed   Mentions: 247     Fields:    Translation:HumansAnimalsCells
    7. Identification of novel loci affecting circulating chromogranins and related peptides. Hum Mol Genet. 2017 01 01; 26(1):233-242. Benyamin B, Maihofer AX, Schork AJ, Hamilton BA, Rao F, Schmid-Schönbein GW, Zhang K, Mahata M, Stridsberg M, Schork NJ, Biswas N, Hook VY, Wei Z, Montgomery GW, Martin NG, Nievergelt CM, Whitfield JB, O'Connor DT. PMID: 28011710; PMCID: PMC6075630.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    8. Deep Reads: Favorites from a Few Different Shelves. PLoS Genet. 2016 Dec; 12(12):e1006476. Hamilton BA. PMID: 27977693; PMCID: PMC5157940.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function. Immunity. 2016 11 15; 45(5):975-987. Thomas GD, Hanna RN, Vasudevan NT, Hamers AA, Romanoski CE, McArdle S, Ross KD, Blatchley A, Yoakum D, Hamilton BA, Mikulski Z, Jain MK, Glass CK, Hedrick CC. PMID: 27814941; PMCID: PMC5694686.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    10. Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function. PLoS Genet. 2016 Oct; 12(10):e1006357. Hong CJ, Hamilton BA. PMID: 27727273; PMCID: PMC5065120.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    11. Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies. PLoS Genet. 2015 Jul; 11(7):e1005344. Zhang S, Ross KD, Seidner GA, Gorman MR, Poon TH, Wang X, Keithley EM, Lee PN, Martindale MQ, Joiner WJ, Hamilton BA. PMID: 26131556; PMCID: PMC4488434.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects. PLoS Genet. 2015 Apr; 11(4):e1005123. Concepcion D, Ross KD, Hutt KR, Yeo GW, Hamilton BA. PMID: 25835743; PMCID: PMC4383553.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    13. Zfp423 binds autoregulatory sites in p19 cell culture model. PLoS One. 2013; 8(6):e66514. Cho YW, Hong CJ, Hou A, Gent PM, Zhang K, Won KJ, Hamilton BA. PMID: 23762491; PMCID: PMC3675209.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    14. Retrotransposon activates ectopic Ptf1 expression: a short tail. PLoS Genet. 2013; 9(2):e1003331. Hamilton BA. PMID: 23468657; PMCID: PMC3578763.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell. 2012 Aug 03; 150(3):533-48. Chaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, Wang H, Hurd TW, Zhou W, Cluckey A, Gee HY, Ramaswami G, Hong CJ, Hamilton BA, Cervenka I, Ganji RS, Bryja V, Arts HH, van Reeuwijk J, Oud MM, Letteboer SJ, Roepman R, Husson H, Ibraghimov-Beskrovnaya O, Yasunaga T, Walz G, Eley L, Sayer JA, Schermer B, Liebau MC, Benzing T, Le Corre S, Drummond I, Janssen S, Allen SJ, Natarajan S, O'Toole JF, Attanasio M, Saunier S, Antignac C, Koenekoop RK, Ren H, Lopez I, Nayir A, Stoetzel C, Dollfus H, Massoudi R, Gleeson JG, Andreoli SP, Doherty DG, Lindstrad A, Golzio C, Katsanis N, Pape L, Abboud EB, Al-Rajhi AA, Lewis RA, Omran H, Lee EY, Wang S, Sekiguchi JM, Saunders R, Johnson CA, Garner E, Vanselow K, Andersen JS, Shlomai J, Nurnberg G, Nurnberg P, Levy S, Smogorzewska A, Otto EA, Hildebrandt F. PMID: 22863007; PMCID: PMC3433835.
      View in: PubMed   Mentions: 223     Fields:    Translation:HumansAnimalsCells
    16. Modifier genes and the plasticity of genetic networks in mice. PLoS Genet. 2012; 8(4):e1002644. Hamilton BA, Yu BD. PMID: 22511884; PMCID: PMC3325199.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    17. Tracking intron removal in real time. Dev Cell. 2011 Dec 13; 21(6):979-80. Hamilton BA, Fu XD. PMID: 22172665; PMCID: PMC4442631.
      View in: PubMed   Mentions: 2     Fields:    
    18. Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins. Am J Hypertens. 2012 Jan; 25(1):29-40. Rao F, Chiron S, Wei Z, Fung MM, Chen Y, Wen G, Khandrika S, Ziegler MG, Benyamin B, Montgomery G, Whitfield JB, Martin NG, Waalen J, Hamilton BA, Mahata SK, O'Connor DT. PMID: 21918574; PMCID: PMC3664223.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Modifier genes and non-genetic factors reshape anatomical deficits in Zfp423-deficient mice. Hum Mol Genet. 2011 Oct 01; 20(19):3822-30. Alcaraz WA, Chen E, Valdes P, Kim E, Lo YH, Vo J, Hamilton BA. PMID: 21729880; PMCID: PMC3168291.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    20. Modifier genes for mouse phosphatidylinositol transfer protein α (vibrator) that bypass juvenile lethality. Genetics. 2011 Apr; 187(4):1185-91. Concepcion D, Johannes F, Lo YH, Yao J, Fong J, Hamilton BA. PMID: 21321132; PMCID: PMC3070526.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    21. Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension. Curr Hypertens Rep. 2011 Feb; 13(1):36-45. Zhang K, Chen Y, Wen G, Mahata M, Rao F, Fung MM, Vaingankar S, Biswas N, Gayen JR, Friese RS, Mahata SK, Hamilton BA, O'Connor DT. PMID: 21104344; PMCID: PMC3016145.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    22. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cell Mol Neurobiol. 2010 Nov; 30(8):1395-400. Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton BA, O'Connor DT. PMID: 21061160; PMCID: PMC3008929.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    23. Common charge-shift mutation Glu65Lys in K+ channel β₁-Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease. Am J Nephrol. 2010; 32(5):414-24. Chen Y, Salem RM, Rao F, Fung MM, Bhatnagar V, Pandey B, Mahata M, Waalen J, Nievergelt CM, Lipkowitz MS, Hamilton BA, Mahata SK, O'Connor DT. PMID: 20861615; PMCID: PMC2975731.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. Human dopamine β-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure. Am J Hypertens. 2011 Jan; 24(1):24-32. Chen Y, Zhang K, Wen G, Rao F, Sanchez AP, Wang L, Rodriguez-Flores JL, Mahata M, Mahata SK, Waalen J, Ziegler MG, Hamilton BA, O'Connor DT. PMID: 20814407; PMCID: PMC4906639.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach. Mamm Genome. 2010 Apr; 21(3-4):195-204. Rodríguez-Flores JL, Zhang K, Kang SW, Wen G, Ghosh S, Friese RS, Mahata SK, Subramaniam S, Hamilton BA, O'Connor DT. PMID: 20204374; PMCID: PMC2844968.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    26. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure. J Hypertens. 2010 Jan; 28(1):76-86. Chen Y, Wen G, Rao F, Zhang K, Wang L, Rodriguez-Flores JL, Sanchez AP, Mahata M, Taupenot L, Sun P, Mahata SK, Tayo B, Schork NJ, Ziegler MG, Hamilton BA, O'Connor DT. PMID: 20009769; PMCID: PMC2860271.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    27. Letter to the editor on "Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals". Biochem Biophys Res Commun. 2010 Jan 01; 391(1):1154. Hamilton BA. PMID: 19903454.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    28. Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo. J Clin Endocrinol Metab. 2009 Nov; 94(11):4557-66. Shih PA, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT. PMID: 19820027; PMCID: PMC2775651.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    29. Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo. J Am Coll Cardiol. 2009 Sep 01; 54(10):944-54. Wang L, Rao F, Zhang K, Mahata M, Rodriguez-Flores JL, Fung MM, Waalen J, Cockburn MG, Hamilton BA, Mahata SK, O'Connor DT. PMID: 19712806; PMCID: PMC2792636.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    30. Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis. J Am Soc Nephrol. 2009 Jul; 20(7):1623-32. Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung MM, Zhang K, Stridsberg M, Ziegler MG, Hamilton BA, Lipkowitz MS, Taupenot L, Nievergelt C, Mahata SK, O'Connor DT. PMID: 19520754; PMCID: PMC2709688.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    31. Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing. PLoS Genet. 2009 May; 5(5):e1000484. Concepcion D, Flores-García L, Hamilton BA. PMID: 19436707; PMCID: PMC2674570.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    32. Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. J Am Coll Cardiol. 2008 Oct 28; 52(18):1468-81. Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT. PMID: 19017515; PMCID: PMC2659417.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    33. Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure. Kidney Int. 2008 Jul; 74(1):115-25. Chen Y, Rao F, Rodriguez-Flores JL, Mahapatra NR, Mahata M, Wen G, Salem RM, Shih PA, Das M, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, O'Connor DT. PMID: 18432188; PMCID: PMC2576285.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    34. Chromogranin A polymorphisms are associated with hypertensive renal disease. J Am Soc Nephrol. 2008 Mar; 19(3):600-14. Salem RM, Cadman PE, Chen Y, Rao F, Wen G, Hamilton BA, Rana BK, Smith DW, Stridsberg M, Ward HJ, Mahata M, Mahata SK, Bowden DW, Hicks PJ, Freedman BI, Schork NJ, O'Connor DT. PMID: 18235090; PMCID: PMC2391050.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    35. An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension. Hum Mol Genet. 2007 Jul 15; 16(14):1752-64. Wen G, Wessel J, Zhou W, Ehret GB, Rao F, Stridsberg M, Mahata SK, Gent PM, Das M, Cooper RS, Chakravarti A, Zhou H, Schork NJ, O'connor DT, Hamilton BA. PMID: 17584765; PMCID: PMC2695823.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    36. Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension. Circulation. 2007 May 01; 115(17):2271-81. Rao F, Wen G, Gayen JR, Das M, Vaingankar SM, Rana BK, Mahata M, Kennedy BP, Salem RM, Stridsberg M, Abel K, Smith DW, Eskin E, Schork NJ, Hamilton BA, Ziegler MG, Mahata SK, O'Connor DT. PMID: 17438154.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    37. Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism. Hypertension. 2007 May; 49(5):1015-31. Rao F, Wessel J, Wen G, Zhang L, Rana BK, Kennedy BP, Greenwood TA, Salem RM, Chen Y, Khandrika S, Hamilton BA, Smith DW, Holstein-Rathlou NH, Ziegler MG, Schork NJ, O'Connor DT. PMID: 17353515.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    38. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007 Feb; 25(2):329-43. Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum JL, Schork NJ, Schmid-Schönbein GW, O'Connor DT. PMID: 17211240.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    39. Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19424-9. Alcaraz WA, Gold DA, Raponi E, Gent PM, Concepcion D, Hamilton BA. PMID: 17151198; PMCID: PMC1748242.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    40. Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin. Diabetes Obes Metab. 2006 Nov; 8(6):621-33. Zhang K, Rao F, Wen G, Salem RM, Vaingankar S, Mahata M, Mahapatra NR, Lillie EO, Cadman PE, Friese RS, Hamilton BA, Hook VY, Mahata SK, Taupenot L, O'Connor DT. PMID: 17026486; PMCID: PMC10843892.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    41. Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). J Hum Genet. 2006; 51(6):575-580. Bhatnagar V, Xu G, Hamilton BA, Truong DM, Eraly SA, Wu W, Nigam SK. PMID: 16648942.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    42. ROR alpha in genetic control of cerebellum development: 50 staggering years. Brain Res. 2007 Apr 06; 1140:19-25. Gold DA, Gent PM, Hamilton BA. PMID: 16427031.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    43. Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int. 2005 Oct; 68(4):1491-9. Xu G, Bhatnagar V, Wen G, Hamilton BA, Eraly SA, Nigam SK. PMID: 16164626.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    44. Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice. Genetics. 2004 Oct; 168(2):953-9. Concepcion D, Seburn KL, Wen G, Frankel WN, Hamilton BA. PMID: 15514066; PMCID: PMC1448829.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    45. The catecholamine release-inhibitory "catestatin" fragment of chromogranin a: naturally occurring human variants with different potencies for multiple chromaffin cell nicotinic cholinergic responses. Mol Pharmacol. 2004 Nov; 66(5):1180-91. Mahata SK, Mahata M, Wen G, Wong WB, Mahapatra NR, Hamilton BA, O'Connor DT. PMID: 15326220.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    46. alpha-Synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates. Genomics. 2004 Apr; 83(4):739-42. Hamilton BA. PMID: 15028296.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    47. Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. Am J Hum Genet. 2004 Feb; 74(2):197-207. Wen G, Mahata SK, Cadman P, Mahata M, Ghosh S, Mahapatra NR, Rao F, Stridsberg M, Smith DW, Mahboubi P, Schork NJ, O'Connor DT, Hamilton BA. PMID: 14740315; PMCID: PMC1181918.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    48. RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 2003 Dec 18; 40(6):1119-31. Gold DA, Baek SH, Schork NJ, Rose DW, Larsen DD, Sachs BD, Rosenfeld MG, Hamilton BA. PMID: 14687547; PMCID: PMC2717708.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    49. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Nat Genet. 2003 Nov; 35(3):221-8. Floyd JA, Gold DA, Concepcion D, Poon TH, Wang X, Keithley E, Chen D, Ward EJ, Chinn SB, Friedman RA, Yu HT, Moriwaki K, Shiroishi T, Hamilton BA. PMID: 14517553; PMCID: PMC2756099.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    50. Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia. J Biol Chem. 2003 Aug 29; 278(35):33501-18. Alb JG, Cortese JD, Phillips SE, Albin RL, Nagy TR, Hamilton BA, Bankaitis VA. PMID: 12788952; PMCID: PMC7798478.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    51. Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun. 2003 Jan 10; 300(2):333-42. Eraly SA, Hamilton BA, Nigam SK. PMID: 12504088.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    52. Variations in abundance: genome-wide responses to genetic variation and vice versa. Genome Biol. 2002 Sep 19; 3(10):reviews1029. Hamilton BA. PMID: 12372150; PMCID: PMC244913.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    53. Of mice and genome sequence. Cell. 2001 Oct 05; 107(1):13-6. Hamilton BA, Frankel WN. PMID: 11595181.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    54. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet. 2000 Mar 22; 9(5):821-8. Jones JM, Huang JD, Mermall V, Hamilton BA, Mooseker MS, Escayg A, Copeland NG, Jenkins NA, Meisler MH. PMID: 10749990.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    55. Heredity and the autonomic nervous system in human hypertension. Curr Hypertens Rep. 2000 Feb; 2(1):16-22. O'Connor DT, Insel PA, Ziegler MG, Hook VY, Smith DW, Hamilton BA, Taylor PW, Parmer RJ. PMID: 10982526.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    56. Intranuclear inclusions and the ubiquitin-proteasome pathway: digestion of a red herring? Neuron. 1999 Dec; 24(4):765-6. Floyd JA, Hamilton BA. PMID: 10624938.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    57. The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May; 18(5):711-22. Hamilton BA, Smith DJ, Mueller KL, Kerrebrock AW, Bronson RT, van Berkel V, Daly MJ, Kruglyak L, Reeve MP, Nemhauser JL, Hawkins TL, Rubin EM, Lander ES. PMID: 9182797.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    58. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 1996 Feb 22; 379(6567):736-9. Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES. PMID: 8602221.
      View in: PubMed   Mentions: 177     Fields:    Translation:AnimalsCells
    59. Targeted mutagenesis and genetic analysis of a Drosophila receptor-linked protein tyrosine phosphatase gene. Rouxs Arch Dev Biol. 1995 Jan; 204(3):187-192. Hamilton BA, Ho A, Zinn K. PMID: 28305958.
      View in: PubMed   Mentions: 4  
    60. The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell. 1994 Sep 23; 78(6):1073-87. Hästbacka J, de la Chapelle A, Mahtani MM, Clines G, Reeve-Daly MP, Daly M, Hamilton BA, Kusumi K, Trivedi B, Weaver A, et al. PMID: 7923357.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    61. From clone to mutant gene. Methods Cell Biol. 1994; 44:81-94. Hamilton BA, Zinn K. PMID: 7707978.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    62. Rapid isolation of long cDNA clones from existing libraries. Nucleic Acids Res. 1991 Apr 25; 19(8):1951-2. Hamilton BA, Palazzolo MJ, Meyerowitz EM. PMID: 1903205; PMCID: PMC328137.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    63. Large scale screen for transposon insertions into cloned genes. Proc Natl Acad Sci U S A. 1991 Apr 01; 88(7):2731-5. Hamilton BA, Palazzolo MJ, Chang JH, VijayRaghavan K, Mayeda CA, Whitney MA, Meyerowitz EM. PMID: 1849274; PMCID: PMC51312.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    64. Transposon-facilitated DNA sequencing. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1247-50. Strathmann M, Hamilton BA, Mayeda CA, Simon MI, Meyerowitz EM, Palazzolo MJ. PMID: 1847513; PMCID: PMC50994.
      View in: PubMed   Mentions: 75     Fields:    Translation:Cells
    65. Phage lambda cDNA cloning vectors for subtractive hybridization, fusion-protein synthesis and Cre-loxP automatic plasmid subcloning. Gene. 1990 Mar 30; 88(1):25-36. Palazzolo MJ, Hamilton BA, Ding DL, Martin CH, Mead DA, Mierendorf RC, Raghavan KV, Meyerowitz EM, Lipshitz HD. PMID: 2140336.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
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