Bruce Hamilton

InstitutionUniversity of California San Diego
DepartmentCellular and Molecular Medicine
Address9500 Gilman Drive #0644
La Jolla CA 92093
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    Collapse Biography 
    Collapse Awards and Honors
    Office of National Drug Control Policy2001Certificate of Appreciation
    Pew Trusts1999  - 2003Pew Scholar in the Biomedical Sciences
    March of Dimes1999  - 2001Basil O’Connor Starter Scholars Award
    Helen Hay Whitney Foundation1993  - 1996Postdoctoral Fellowship

    Collapse Overview 
    Collapse Overview
    Dr. Hamilton is currently Professor, Director of the UCSD Genetics Training Program, co-organizer of Genetics and Genomics in Biomedical Sciences Graduate Program, and a founding member of the executive committee for the UCSD Institute for Genomic Medicine. He graduated from UCSD's Revelle College in 1986 with a degree in Molecular Biology. He completed his PhD at Caltech, using Drosophila genetics and developing new genetic methods to understand development of the nervous system. As a Helen Hay Whitney postdoctoral fellow at the Whitehead Institute, he extended genetic and genomic approaches to identifying genes in human disease and experimental mouse models. In 1998, Dr. Hamilton returned to UCSD as Assistant Professor in the Division of Genetics. His laboratory is interested in modifier gene networks, genetic control of neural development, and genetic variation in neural control of blood pressure. His work has been funded by several NIH Institutes, the March of Dimes and an award from the Pew Scholars Program in Biomedical Sciences.

    - 1986 - B. A. (Molecular Biology), University of California, San Diego, CA
    - 1993 - Ph.D. (Biology), California Institute of Technology, Pasadena, California

    - 2011 - Present: Professor, Division of Genetics, Department of Medicine
    - 2010 - Present: Associate Director, UCSD Institute for Genomic Medicine
    - 2007 - Present: Director, UCSD Genetics Training Program
    - 2005 - 2011: Associate Professor, Division of Genetics, Department of Medicine, and Associate Adjunct Professor, Department of Cellular and Molecular Medicine, University of California, San Diego, CA.
    - 2000 - Present: Participating Member, Cancer Genetics Program, Rebecca and John Moores UCSD Cancer Center.
    - 1999-2005: Assistant Adjunct Professor, Department of Cellular and Molecular Medicine, University of California, San Diego.
    - 1998-2005: Assistant Professor, Division of Genetics, Department of Medicine, University of California, San Diego.
    - 1996-1998: Postdoctoral Associate, Whitehead Institute for Biomedical Research, in the laboratory of Eric Lander.

    Collapse Research 
    Collapse Research Activities and Funding
    Zfp423 Mechanisms in Joubert Syndrome and Related Disorders
    NIH/NINDS R01NS097534Feb 1, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Mouse models of ZNF804A
    NIH/NIMH R21MH109960Apr 15, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Synthetic Lethal Modifier of a New Ciliopathy Gene
    NIH/NIGMS R01GM102958Jul 27, 2012 - Apr 30, 2016
    Role: Principal Investigator
    Genetic Analysis of Neural Stem Cells
    NIH/NINDS R01NS060109Dec 15, 2007 - Nov 30, 2013
    Role: Principal Investigator
    Genetic Mechanisms in Cerebellum Malformations
    NIH/NINDS R01NS054871May 7, 2007 - Mar 31, 2013
    Role: Principal Investigator
    Sympathetic Neuroeffector Junctions &Blood Pressure
    NIH P01HL058120Jun 1, 1999 - May 31, 2012
    Role: Co-Investigator
    Genetic Modifier Activity and Network Properties of Nxf1
    NIH/NIGMS R01GM086912Dec 1, 1998 - Dec 31, 2020
    Role: Principal Investigator
    NIH/NIMH R01MH059207Dec 1, 1998 - Nov 30, 2009
    Role: Principal Investigator
    Training Program in Basic and Clinical Genetics
    NIH/NIGMS T32GM008666Jul 1, 1998 - Jun 30, 2022
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Massimino L, Flores-Garcia L, Di Stefano B, Colasante G, Icoresi-Mazzeo C, Zaghi M, Hamilton BA, Sessa A. TBR2 antagonizes retinoic acid dependent neuronal differentiation by repressing Zfp423 during corticogenesis. Dev Biol. 2018 02 15; 434(2):231-248. PMID: 29305158.
      View in: PubMed
    2. Beable S, Fulcher M, Lee AC, Hamilton B. SHARPSports mental Health Awareness Research Project: Prevalence and risk factors of depressive symptoms and life stress in elite athletes. J Sci Med Sport. 2017 Dec; 20(12):1047-1052. PMID: 28601589.
      View in: PubMed
    3. Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G. Regeneration of fat cells from myofibroblasts during wound healing. Science. 2017 02 17; 355(6326):748-752. PMID: 28059714.
      View in: PubMed
    4. Benyamin B, Maihofer AX, Schork AJ, Hamilton BA, Rao F, Schmid-Schönbein GW, Zhang K, Mahata M, Stridsberg M, Schork NJ, Biswas N, Hook VY, Wei Z, Montgomery GW, Martin NG, Nievergelt CM, Whitfield JB, O'Connor DT. Identification of novel loci affecting circulating chromogranins and related peptides. Hum Mol Genet. 2017 01 01; 26(1):233-242. PMID: 28011710.
      View in: PubMed
    5. Hamilton BA. Deep Reads: Favorites from a Few Different Shelves. PLoS Genet. 2016 Dec; 12(12):e1006476. PMID: 27977693.
      View in: PubMed
    6. Thomas GD, Hanna RN, Vasudevan NT, Hamers AA, Romanoski CE, McArdle S, Ross KD, Blatchley A, Yoakum D, Hamilton BA, Mikulski Z, Jain MK, Glass CK, Hedrick CC. Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function. Immunity. 2016 11 15; 45(5):975-987. PMID: 27814941.
      View in: PubMed
    7. Hong CJ, Hamilton BA. Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function. PLoS Genet. 2016 Oct; 12(10):e1006357. PMID: 27727273.
      View in: PubMed
    8. Zhang S, Ross KD, Seidner GA, Gorman MR, Poon TH, Wang X, Keithley EM, Lee PN, Martindale MQ, Joiner WJ, Hamilton BA. Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies. PLoS Genet. 2015 Jul; 11(7):e1005344. PMID: 26131556; PMCID: PMC4488434.
    9. Concepcion D, Ross KD, Hutt KR, Yeo GW, Hamilton BA. Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects. PLoS Genet. 2015 Apr; 11(4):e1005123. PMID: 25835743; PMCID: PMC4383553.
    10. Allison RJ, Farooq A, Hamilton B, Close GL, Wilson MG. No association between vitamin D deficiency and markers of bone health in athletes. Med Sci Sports Exerc. 2015 Apr; 47(4):782-8. PMID: 25058327.
      View in: PubMed
    11. Cho YW, Hong CJ, Hou A, Gent PM, Zhang K, Won KJ, Hamilton BA. Zfp423 binds autoregulatory sites in p19 cell culture model. PLoS One. 2013; 8(6):e66514. PMID: 23762491; PMCID: PMC3675209.
    12. Riding NR, Salah O, Sharma S, Carré F, George KP, Farooq A, Hamilton B, Chalabi H, Whyte GP, Wilson MG. ECG and morphologic adaptations in Arabic athletes: are the European Society of Cardiology's recommendations for the interpretation of the 12-lead ECG appropriate for this ethnicity? Br J Sports Med. 2014 Aug; 48(15):1138-43. PMID: 23564906.
      View in: PubMed
    13. Hamilton BA. Retrotransposon activates ectopic Ptf1 expression: a short tail. PLoS Genet. 2013; 9(2):e1003331. PMID: 23468657; PMCID: PMC3578763.
    14. Chaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, Wang H, Hurd TW, Zhou W, Cluckey A, Gee HY, Ramaswami G, Hong CJ, Hamilton BA, Cervenka I, Ganji RS, Bryja V, Arts HH, van Reeuwijk J, Oud MM, Letteboer SJ, Roepman R, Husson H, Ibraghimov-Beskrovnaya O, Yasunaga T, Walz G, Eley L, Sayer JA, Schermer B, Liebau MC, Benzing T, Le Corre S, Drummond I, Janssen S, Allen SJ, Natarajan S, O'Toole JF, Attanasio M, Saunier S, Antignac C, Koenekoop RK, Ren H, Lopez I, Nayir A, Stoetzel C, Dollfus H, Massoudi R, Gleeson JG, Andreoli SP, Doherty DG, Lindstrad A, Golzio C, Katsanis N, Pape L, Abboud EB, Al-Rajhi AA, Lewis RA, Omran H, Lee EY, Wang S, Sekiguchi JM, Saunders R, Johnson CA, Garner E, Vanselow K, Andersen JS, Shlomai J, Nurnberg G, Nurnberg P, Levy S, Smogorzewska A, Otto EA, Hildebrandt F. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell. 2012 Aug 03; 150(3):533-48. PMID: 22863007; PMCID: PMC3433835.
    15. Hamilton BA, Yu BD. Modifier genes and the plasticity of genetic networks in mice. PLoS Genet. 2012; 8(4):e1002644. PMID: 22511884; PMCID: PMC3325199.
    16. Hamilton BA, Fu XD. Tracking intron removal in real time. Dev Cell. 2011 Dec 13; 21(6):979-80. PMID: 22172665; PMCID: PMC4442631.
    17. Rao F, Chiron S, Wei Z, Fung MM, Chen Y, Wen G, Khandrika S, Ziegler MG, Benyamin B, Montgomery G, Whitfield JB, Martin NG, Waalen J, Hamilton BA, Mahata SK, O'Connor DT. Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins. Am J Hypertens. 2012 Jan; 25(1):29-40. PMID: 21918574; PMCID: PMC3664223.
    18. Characklis GW, Adriaens P, Braden JB, Davis J, Hamilton B, Hughes JB, Small MJ, Wolfe J. Increasing the role of economics in environmental research (or moving beyond the mindset that economics = accounting). Environ Sci Technol. 2011 Aug 01; 45(15):6235-6. PMID: 21740005.
      View in: PubMed
    19. Alcaraz WA, Chen E, Valdes P, Kim E, Lo YH, Vo J, Hamilton BA. Modifier genes and non-genetic factors reshape anatomical deficits in Zfp423-deficient mice. Hum Mol Genet. 2011 Oct 01; 20(19):3822-30. PMID: 21729880; PMCID: PMC3168291.
    20. Concepcion D, Johannes F, Lo YH, Yao J, Fong J, Hamilton BA. Modifier genes for mouse phosphatidylinositol transfer protein a (vibrator) that bypass juvenile lethality. Genetics. 2011 Apr; 187(4):1185-91. PMID: 21321132; PMCID: PMC3070526.
    21. Zhang K, Chen Y, Wen G, Mahata M, Rao F, Fung MM, Vaingankar S, Biswas N, Gayen JR, Friese RS, Mahata SK, Hamilton BA, O'Connor DT. Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension. Curr Hypertens Rep. 2011 Feb; 13(1):36-45. PMID: 21104344; PMCID: PMC3016145.
    22. Hamilton BA, Naismith SL, Scott EM, Purcell S, Hickie IB. Disability is already pronounced in young people with early stages of affective disorders: data from an early intervention service. J Affect Disord. 2011 Jun; 131(1-3):84-91. PMID: 21112640.
      View in: PubMed
    23. Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton BA, O'Connor DT. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cell Mol Neurobiol. 2010 Nov; 30(8):1395-400. PMID: 21061160; PMCID: PMC3008929.
    24. Chen Y, Salem RM, Rao F, Fung MM, Bhatnagar V, Pandey B, Mahata M, Waalen J, Nievergelt CM, Lipkowitz MS, Hamilton BA, Mahata SK, O'Connor DT. Common charge-shift mutation Glu65Lys in K+ channel ß1-Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease. Am J Nephrol. 2010; 32(5):414-24. PMID: 20861615; PMCID: PMC2975731.
    25. Chen Y, Zhang K, Wen G, Rao F, Sanchez AP, Wang L, Rodriguez-Flores JL, Mahata M, Mahata SK, Waalen J, Ziegler MG, Hamilton BA, O'Connor DT. Human dopamine ß-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure. Am J Hypertens. 2011 Jan; 24(1):24-32. PMID: 20814407; PMCID: PMC4906639.
    26. McCance DR, Holmes VA, Maresh MJ, Patterson CC, Walker JD, Pearson DW, Young IS. Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial. Lancet. 2010 Jul 24; 376(9737):259-66. PMID: 20580423; PMCID: PMC2911677.
    27. Rodríguez-Flores JL, Zhang K, Kang SW, Wen G, Ghosh S, Friese RS, Mahata SK, Subramaniam S, Hamilton BA, O'Connor DT. Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach. Mamm Genome. 2010 Apr; 21(3-4):195-204. PMID: 20204374; PMCID: PMC2844968.
    28. Chen Y, Wen G, Rao F, Zhang K, Wang L, Rodriguez-Flores JL, Sanchez AP, Mahata M, Taupenot L, Sun P, Mahata SK, Tayo B, Schork NJ, Ziegler MG, Hamilton BA, O'Connor DT. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure. J Hypertens. 2010 Jan; 28(1):76-86. PMID: 20009769; PMCID: PMC2860271.
    29. Shih PB, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT. Peptide YY (PYY) Gene Polymorphisms in the 3'-Untranslated Region and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo. Endocr Rev. 2009 Dec 01; 30(7):934. PMID: 28199513.
      View in: PubMed
    30. Hamilton BA. Letter to the editor on "Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals". Biochem Biophys Res Commun. 2010 Jan 01; 391(1):1154. PMID: 19903454.
      View in: PubMed
    31. Shih PA, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT. Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo. J Clin Endocrinol Metab. 2009 Nov; 94(11):4557-66. PMID: 19820027; PMCID: PMC2775651.
    32. Wang L, Rao F, Zhang K, Mahata M, Rodriguez-Flores JL, Fung MM, Waalen J, Cockburn MG, Hamilton BA, Mahata SK, O'Connor DT. Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo. J Am Coll Cardiol. 2009 Sep 01; 54(10):944-54. PMID: 19712806; PMCID: PMC2792636.
    33. Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung MM, Zhang K, Stridsberg M, Ziegler MG, Hamilton BA, Lipkowitz MS, Taupenot L, Nievergelt C, Mahata SK, O'Connor DT. Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis. J Am Soc Nephrol. 2009 Jul; 20(7):1623-32. PMID: 19520754; PMCID: PMC2709688.
    34. Concepcion D, Flores-García L, Hamilton BA. Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing. PLoS Genet. 2009 May; 5(5):e1000484. PMID: 19436707; PMCID: PMC2674570.
    35. Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT. Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. J Am Coll Cardiol. 2008 Oct 28; 52(18):1468-81. PMID: 19017515; PMCID: PMC2659417.
    36. Chen Y, Rao F, Rodriguez-Flores JL, Mahapatra NR, Mahata M, Wen G, Salem RM, Shih PA, Das M, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, O'Connor DT. Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure. Kidney Int. 2008 Jul; 74(1):115-25. PMID: 18432188; PMCID: PMC2576285.
    37. Salem RM, Cadman PE, Chen Y, Rao F, Wen G, Hamilton BA, Rana BK, Smith DW, Stridsberg M, Ward HJ, Mahata M, Mahata SK, Bowden DW, Hicks PJ, Freedman BI, Schork NJ, O'Connor DT. Chromogranin A polymorphisms are associated with hypertensive renal disease. J Am Soc Nephrol. 2008 Mar; 19(3):600-14. PMID: 18235090; PMCID: PMC2391050.
    38. Chen MX, Sandow SL, Doceul V, Chen YH, Harper H, Hamilton B, Meadows HJ, Trezise DJ, Clare JJ. Improved functional expression of recombinant human ether-a-go-go (hERG) K+ channels by cultivation at reduced temperature. BMC Biotechnol. 2007 Dec 20; 7:93. PMID: 18096051; PMCID: PMC2241608.
    39. Wen G, Wessel J, Zhou W, Ehret GB, Rao F, Stridsberg M, Mahata SK, Gent PM, Das M, Cooper RS, Chakravarti A, Zhou H, Schork NJ, O'connor DT, Hamilton BA. An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension. Hum Mol Genet. 2007 Jul 15; 16(14):1752-64. PMID: 17584765; PMCID: PMC2695823.
    40. Harold D, Jehu L, Turic D, Hollingworth P, Moore P, Summerhayes P, Moskvina V, Foy C, Archer N, Hamilton BA, Lovestone S, Powell J, Brayne C, Rubinsztein DC, Jones L, O'Donovan MC, Owen MJ, Williams J. Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 05; 144B(4):448-52. PMID: 17440933.
      View in: PubMed
    41. Rao F, Wen G, Gayen JR, Das M, Vaingankar SM, Rana BK, Mahata M, Kennedy BP, Salem RM, Stridsberg M, Abel K, Smith DW, Eskin E, Schork NJ, Hamilton BA, Ziegler MG, Mahata SK, O'Connor DT. Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension. Circulation. 2007 May 01; 115(17):2271-81. PMID: 17438154.
      View in: PubMed
    42. Rao F, Wessel J, Wen G, Zhang L, Rana BK, Kennedy BP, Greenwood TA, Salem RM, Chen Y, Khandrika S, Hamilton BA, Smith DW, Holstein-Rathlou NH, Ziegler MG, Schork NJ, O'Connor DT. Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism. Hypertension. 2007 May; 49(5):1015-31. PMID: 17353515.
      View in: PubMed
    43. Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum JL, Schork NJ, Schmid-Schönbein GW, O'Connor DT. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007 Feb; 25(2):329-43. PMID: 17211240.
      View in: PubMed
    44. Comer DM, Sharpe PC, Hull D, Hamilton BA. A myeloproliferative disease and pseudohyperkalaemia. Br J Hosp Med (Lond). 2007 Jan; 68(1):47. PMID: 17260719.
      View in: PubMed
    45. Alcaraz WA, Gold DA, Raponi E, Gent PM, Concepcion D, Hamilton BA. Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19424-9. PMID: 17151198; PMCID: PMC1748242.
    46. Zhang K, Rao F, Wen G, Salem RM, Vaingankar S, Mahata M, Mahapatra NR, Lillie EO, Cadman PE, Friese RS, Hamilton BA, Hook VY, Mahata SK, Taupenot L, O'Connor DT. Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin. Diabetes Obes Metab. 2006 Nov; 8(6):621-33. PMID: 17026486.
      View in: PubMed
    47. Bhatnagar V, Xu G, Hamilton BA, Truong DM, Eraly SA, Wu W, Nigam SK. Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). J Hum Genet. 2006; 51(6):575-80. PMID: 16648942.
      View in: PubMed
    48. Gold DA, Gent PM, Hamilton BA. ROR alpha in genetic control of cerebellum development: 50 staggering years. Brain Res. 2007 Apr 06; 1140:19-25. PMID: 16427031.
      View in: PubMed
    49. Xu G, Bhatnagar V, Wen G, Hamilton BA, Eraly SA, Nigam SK. Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int. 2005 Oct; 68(4):1491-9. PMID: 16164626.
      View in: PubMed
    50. Concepcion D, Seburn KL, Wen G, Frankel WN, Hamilton BA. Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice. Genetics. 2004 Oct; 168(2):953-9. PMID: 15514066; PMCID: PMC1448829.
    51. Mahata SK, Mahata M, Wen G, Wong WB, Mahapatra NR, Hamilton BA, O'Connor DT. The catecholamine release-inhibitory "catestatin" fragment of chromogranin a: naturally occurring human variants with different potencies for multiple chromaffin cell nicotinic cholinergic responses. Mol Pharmacol. 2004 Nov; 66(5):1180-91. PMID: 15326220.
      View in: PubMed
    52. Hamilton BA. alpha-Synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates. Genomics. 2004 Apr; 83(4):739-42. PMID: 15028296.
      View in: PubMed
    53. Wen G, Mahata SK, Cadman P, Mahata M, Ghosh S, Mahapatra NR, Rao F, Stridsberg M, Smith DW, Mahboubi P, Schork NJ, O'Connor DT, Hamilton BA. Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. Am J Hum Genet. 2004 Feb; 74(2):197-207. PMID: 14740315; PMCID: PMC1181918.
    54. Gold DA, Baek SH, Schork NJ, Rose DW, Larsen DD, Sachs BD, Rosenfeld MG, Hamilton BA. RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 2003 Dec 18; 40(6):1119-31. PMID: 14687547; PMCID: PMC2717708.
    55. Floyd JA, Gold DA, Concepcion D, Poon TH, Wang X, Keithley E, Chen D, Ward EJ, Chinn SB, Friedman RA, Yu HT, Moriwaki K, Shiroishi T, Hamilton BA. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Nat Genet. 2003 Nov; 35(3):221-8. PMID: 14517553; PMCID: PMC2756099.
    56. Alb JG, Cortese JD, Phillips SE, Albin RL, Nagy TR, Hamilton BA, Bankaitis VA. Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia. J Biol Chem. 2003 Aug 29; 278(35):33501-18. PMID: 12788952.
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    57. Eraly SA, Hamilton BA, Nigam SK. Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun. 2003 Jan 10; 300(2):333-42. PMID: 12504088.
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    58. Hamilton BA. Variations in abundance: genome-wide responses to genetic variation and vice versa. Genome Biol. 2002 Sep 19; 3(10):reviews1029. PMID: 12372150; PMCID: PMC244913.
    59. Hamilton BA, Frankel WN. Of mice and genome sequence. Cell. 2001 Oct 05; 107(1):13-6. PMID: 11595181.
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    60. Jones JM, Huang JD, Mermall V, Hamilton BA, Mooseker MS, Escayg A, Copeland NG, Jenkins NA, Meisler MH. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet. 2000 Mar 22; 9(5):821-8. PMID: 10749990.
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    61. O'Connor DT, Insel PA, Ziegler MG, Hook VY, Smith DW, Hamilton BA, Taylor PW, Parmer RJ. Heredity and the autonomic nervous system in human hypertension. Curr Hypertens Rep. 2000 Feb; 2(1):16-22. PMID: 10982526.
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    62. Floyd JA, Hamilton BA. Intranuclear inclusions and the ubiquitin-proteasome pathway: digestion of a red herring? Neuron. 1999 Dec; 24(4):765-6. PMID: 10624938.
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    63. Hamilton BA, Smith DJ, Mueller KL, Kerrebrock AW, Bronson RT, van Berkel V, Daly MJ, Kruglyak L, Reeve MP, Nemhauser JL, Hawkins TL, Rubin EM, Lander ES. The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May; 18(5):711-22. PMID: 9182797.
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    64. Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 1996 Feb 22; 379(6567):736-9. PMID: 8602221.
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    65. Hamilton BA, Ho A, Zinn K. Targeted mutagenesis and genetic analysis of a Drosophila receptor-linked protein tyrosine phosphatase gene. Roux Arch Dev Biol. 1995 Jan; 204(3):187-192. PMID: 28305958.
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    66. Hästbacka J, de la Chapelle A, Mahtani MM, Clines G, Reeve-Daly MP, Daly M, Hamilton BA, Kusumi K, Trivedi B, Weaver A. The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell. 1994 Sep 23; 78(6):1073-87. PMID: 7923357.
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    67. Hamilton BA, Zinn K. From clone to mutant gene. Methods Cell Biol. 1994; 44:81-94. PMID: 7707978.
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    68. Hamilton BA, Palazzolo MJ, Meyerowitz EM. Rapid isolation of long cDNA clones from existing libraries. Nucleic Acids Res. 1991 Apr 25; 19(8):1951-2. PMID: 1903205; PMCID: PMC328137.
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