Loading...

Joan Heller Brown

Title(s)Distinguished Professor and Department Chair, Pharmacology
SchoolHealth Sciences
Phone858-534-2595
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Ph.D.Albert Einstein College of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Cardiomyocyte CaM kinase II as a driver of cardiac inflammation and remodeling
    NIH/NHLBI R01HL145459Dec 15, 2018 - Nov 30, 2022
    Role: Principal Investigator
    RhoA and GPCR mediated transcriptional activation regulates glioblastoma
    NIH/NCI R01CA218859Feb 9, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Restoring Mycocardial Healing
    NIH P01HL085577Jul 1, 2006 - Jul 31, 2018
    Role: Co-Investigator
    SAP KINASES IN GQ INDUCED APOPTOTIC HEART FAILURE
    NIH/NHLBI R01HL061505Sep 30, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH/NHLBI P01HL046345Feb 1, 1992 - Jun 30, 2014
    Role: Co-Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    RhoA mediated survival signals in cardiomyocytes
    NIH/NHLBI R37HL028143Aug 1, 1982 - Jan 31, 2020
    Role: Principal Investigator
    Rho- and GPCR-mediated signaling through novel cellular effectors
    NIH/NIGMS R01GM036927Aug 1, 1982 - Aug 31, 2013
    Role: Principal Investigator
    S1P, Rho and Akt signaling in cardiomyocyte survival
    NIH/NHLBI R01HL028143Aug 1, 1982 - Mar 31, 2010
    Role: Principal Investigator
    Rho- and GPCR-mediated signaling through novel cellular effectors
    NIH/NIGMS R56GM036927Aug 1, 1982 - Aug 31, 2009
    Role: Principal Investigator
    Graduate Training in Cellular and Molecular Pharmacology
    NIH/NIGMS T32GM007752Jul 1, 1979 - Jun 30, 2024
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Suetomi T, Miyamoto S, Brown JH. Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling. Am J Physiol Heart Circ Physiol. 2019 Nov 01; 317(5):H877-H890. PMID: 31441689.
      View in: PubMed
    2. Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S, Brown JH. Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca2+/Calmodulin-Dependent Protein Kinase II d Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling. Circulation. 2018 11 27; 138(22):2530-2544. PMID: 30571348.
      View in: PubMed
    3. Brand CS, Tan VP, Brown JH, Miyamoto S. RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes. Cell Signal. 2018 Oct; 50:48-57. PMID: 29953931.
      View in: PubMed
    4. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507. PMID: 29887596.
      View in: PubMed
    5. Crotty Alexander LE, Drummond CA, Hepokoski M, Mathew D, Moshensky A, Willeford A, Das S, Singh P, Yong Z, Lee JH, Vega K, Du A, Shin J, Javier C, Tian J, Brown JH, Breen EC. Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Physiol Regul Integr Comp Physiol. 2018 06 01; 314(6):R834-R847. PMID: 29384700.
      View in: PubMed
    6. Dusaban SS, Chun J, Rosen H, Purcell NH, Brown JH. Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes. J Neuroinflammation. 2017 06 02; 14(1):111. PMID: 28577576.
      View in: PubMed
    7. Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A. Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic ß-Adrenoceptor Blockade in Experimental and Human Heart Failure. Circ Heart Fail. 2017 May; 10(5):e003840. PMID: 28487342.
      View in: PubMed
    8. Gray CB, Suetomi T, Xiang S, Mishra S, Blackwood EA, Glembotski CC, Miyamoto S, Westenbrink BD, Brown JH. CaMKIId subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-?B and TNF-a. J Mol Cell Cardiol. 2017 02; 103:48-55. PMID: 28077321.
      View in: PubMed
    9. Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell NH, Brown JH, Miyamoto S. Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. J Mol Cell Cardiol. 2017 02; 103:1-10. PMID: 28017639.
      View in: PubMed
    10. Høydal MA, Stølen TO, Kettlewell S, Maier LS, Brown JH, Sowa T, Catalucci D, Condorelli G, Kemi OJ, Smith GL, Wisløff U. Exercise training reverses myocardial dysfunction induced by CaMKIIdC overexpression by restoring Ca2+ homeostasis. J Appl Physiol (1985). 2016 07 01; 121(1):212-20. PMID: 27231311.
      View in: PubMed
    11. Castaldi A, Chesini GP, Taylor AE, Sussman MA, Brown JH, Purcell NH. Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. Cell Signal. 2016 08; 28(8):871-9. PMID: 27094722.
      View in: PubMed
    12. Miyamoto S, Brown JH. Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload. Circulation. 2016 Mar 29; 133(13):1225-7. PMID: 26915632.
      View in: PubMed
    13. Panama BK, Korogyi AS, Aschar-Sobbi R, Oh Y, Gray CB, Gang H, Brown JH, Kirshenbaum LA, Backx PH. Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic ß-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor ?B. J Biol Chem. 2016 Feb 19; 291(8):4156-65. PMID: 26742842.
      View in: PubMed
    14. Sanna MG, Vincent KP, Repetto E, Nguyen N, Brown SJ, Abgaryan L, Riley SW, Leaf NB, Cahalan SM, Kiosses WB, Kohno Y, Brown JH, McCulloch AD, Rosen H, Gonzalez-Cabrera PJ. Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. Mol Pharmacol. 2016 Jan; 89(1):176-86. PMID: 26494861.
      View in: PubMed
    15. Yu OM, Miyamoto S, Brown JH. Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation. Mol Cell Biol. 2016 Jan 01; 36(1):39-49. PMID: 26459764.
      View in: PubMed
    16. Dusaban SS, Kunkel MT, Smrcka AV, Brown JH. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C?. J Biol Chem. 2015 Oct 30; 290(44):26776-83. PMID: 26350460.
      View in: PubMed
    17. Grimm M, Ling H, Willeford A, Pereira L, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers DM, Brown JH. CaMKIId mediates ß-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ß-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91. PMID: 26080362.
      View in: PubMed
    18. Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF. The First 50 Years of Molecular Pharmacology. Mol Pharmacol. 2015 Jul; 88(1):139-40. PMID: 25943115.
      View in: PubMed
    19. Yu OM, Brown JH. G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation. Mol Pharmacol. 2015 Jul; 88(1):171-80. PMID: 25904553.
      View in: PubMed
    20. Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. Mitochondrial reprogramming induced by CaMKIId mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39. PMID: 25605649.
      View in: PubMed
    21. van Oort RJ, Brown JH, Westenbrink BD. CaMKII confirms its promise in ischaemic heart disease. Eur J Heart Fail. 2014 Dec; 16(12):1268-9. PMID: 25452163.
      View in: PubMed
    22. Dusaban SS, Brown JH. PLCe mediated sustained signaling pathways. Adv Biol Regul. 2015 Jan; 57:17-23. PMID: 25453218.
      View in: PubMed
    23. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. PMID: 25236710.
      View in: PubMed
    24. Zhao X, Ding EY, Yu OM, Xiang SY, Tan-Sah VP, Yung BS, Hedgpeth J, Neubig RR, Lau LF, Brown JH, Miyamoto S. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. J Mol Cell Cardiol. 2014 Oct; 75:152-61. PMID: 25106095.
      View in: PubMed
    25. Di Carlo MN, Said M, Ling H, Valverde CA, De Giusti VC, Sommese L, Palomeque J, Aiello EA, Skapura DG, Rinaldi G, Respress JL, Brown JH, Wehrens XH, Salas MA, Mattiazzi A. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2014 Sep; 74:274-83. PMID: 24949568.
      View in: PubMed
    26. Suarez J, Wang H, Scott BT, Ling H, Makino A, Swanson E, Brown JH, Suarez JA, Feinstein S, Diaz-Juarez J, Dillmann WH. In vivo selective expression of thyroid hormone receptor a1 in endothelial cells attenuates myocardial injury in experimental myocardial infarction in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Aug 01; 307(3):R340-6. PMID: 24848360.
      View in: PubMed
    27. Sayyah J, Bartakova A, Nogal N, Quilliam LA, Stupack DG, Brown JH. The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. J Biol Chem. 2014 Jun 20; 289(25):17689-98. PMID: 24790104.
      View in: PubMed
    28. Gray CB, Heller Brown J. CaMKIIdelta subtypes: localization and function. Front Pharmacol. 2014; 5:15. PMID: 24575042.
      View in: PubMed
    29. Benincá C, Planagumà J, de Freitas Shuck A, Acín-Perez R, Muñoz JP, de Almeida MM, Brown JH, Murphy AN, Zorzano A, Enríquez JA, Aragay AM. A new non-canonical pathway of Ga(q) protein regulating mitochondrial dynamics and bioenergetics. Cell Signal. 2014 May; 26(5):1135-46. PMID: 24444709.
      View in: PubMed
    30. Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Heller Brown J. PLCe, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. Sci Signal. 2013 Dec 17; 6(306):ra108. PMID: 24345679.
      View in: PubMed
    31. Zhang DM, Chai Y, Erickson JR, Brown JH, Bers DM, Lin YF. Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. J Physiol. 2014 Mar 01; 592(5):971-90. PMID: 24277866.
      View in: PubMed
    32. Westenbrink BD, Edwards AG, McCulloch AD, Brown JH. The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias. Expert Opin Ther Targets. 2013 Aug; 17(8):889-903. PMID: 23789646.
      View in: PubMed
    33. Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, Brown JH. Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3609-14. PMID: 23401561.
      View in: PubMed
    34. Ling H, Gray CB, Zambon AC, Grimm M, Gu Y, Dalton N, Purcell NH, Peterson K, Brown JH. Ca2+/Calmodulin-dependent protein kinase II d mediates myocardial ischemia/reperfusion injury through nuclear factor-?B. Circ Res. 2013 Mar 15; 112(6):935-44. PMID: 23388157.
      View in: PubMed
    35. Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM. Epac2 mediates cardiac ß1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22. PMID: 23363625.
      View in: PubMed
    36. Chen B, Van Winkle JA, Lyden PD, Brown JH, Purcell NH. PHLPP1 gene deletion protects the brain from ischemic injury. J Cereb Blood Flow Metab. 2013 Feb; 33(2):196-204. PMID: 23072745.
      View in: PubMed
    37. Xiang SY, Dusaban SS, Brown JH. Lysophospholipid receptor activation of RhoA and lipid signaling pathways. Biochim Biophys Acta. 2013 Jan; 1831(1):213-22. PMID: 22986288.
      View in: PubMed
    38. Mo JS, Yu FX, Gong R, Brown JH, Guan KL. Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev. 2012 Oct 01; 26(19):2138-43. PMID: 22972936.
      View in: PubMed
    39. Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE, Purcell NH, Catalucci D, Akasaka T, Bueno OF, Vlasuk GP, Kaliman P, Bodmer R, Smith LH, Ashley E, Mercola M, Brown JH, Ruiz-Lozano P. APJ acts as a dual receptor in cardiac hypertrophy. Nature. 2012 Aug 16; 488(7411):394-8. PMID: 22810587.
      View in: PubMed
    40. Ortiz-Sanchez JM, Nichols SE, Sayyah J, Brown JH, McCammon JA, Grant BJ. Identification of potential small molecule binding pockets on Rho family GTPases. PLoS One. 2012; 7(7):e40809. PMID: 22815826.
      View in: PubMed
    41. Guo T, Zhang T, Ginsburg KS, Mishra S, Brown JH, Bers DM. CaMKIIdC slows [Ca]i decline in cardiac myocytes by promoting Ca sparks. Biophys J. 2012 Jun 06; 102(11):2461-70. PMID: 22713561.
      View in: PubMed
    42. Smrcka AV, Brown JH, Holz GG. Role of phospholipase Ce in physiological phosphoinositide signaling networks. Cell Signal. 2012 Jun; 24(6):1333-43. PMID: 22286105.
      View in: PubMed
    43. Grant BJ, Lukman S, Hocker HJ, Sayyah J, Brown JH, McCammon JA, Gorfe AA. Novel allosteric sites on Ras for lead generation. PLoS One. 2011; 6(10):e25711. PMID: 22046245.
      View in: PubMed
    44. Mishra S, Gray CB, Miyamoto S, Bers DM, Brown JH. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res. 2011 Dec 09; 109(12):1354-62. PMID: 21998325.
      View in: PubMed
    45. Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, Brown JH. RhoA protects the mouse heart against ischemia/reperfusion injury. J Clin Invest. 2011 Aug; 121(8):3269-76. PMID: 21747165.
      View in: PubMed
    46. Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res. 2011 Jul 08; 109(2):141-50. PMID: 21597010.
      View in: PubMed
    47. Grimm M, Ling H, Brown JH. Crossing signals: relationships between ß-adrenergic stimulation and CaMKII activation. Heart Rhythm. 2011 Aug; 8(8):1296-8. PMID: 21354330.
      View in: PubMed
    48. Anderson ME, Brown JH, Bers DM. CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol. 2011 Oct; 51(4):468-73. PMID: 21276796.
      View in: PubMed
    49. Dybkova N, Sedej S, Napolitano C, Neef S, Rokita AG, Hünlich M, Brown JH, Kockskämper J, Priori SG, Pieske B, Maier LS. Overexpression of CaMKIIdc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality. J Am Coll Cardiol. 2011 Jan 25; 57(4):469-79. PMID: 21251589.
      View in: PubMed
    50. Cheng Z, Völkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA. Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Eur Heart J. 2011 Sep; 32(17):2179-88. PMID: 21228009.
      View in: PubMed
    51. Mishra S, Ling H, Grimm M, Zhang T, Bers DM, Brown JH. Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling. J Cardiovasc Pharmacol. 2010 Dec; 56(6):598-603. PMID: 20531218.
      View in: PubMed
    52. Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers DM. SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIdC. J Mol Cell Cardiol. 2011 Jan; 50(1):230-8. PMID: 20971119.
      View in: PubMed
    53. Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown JH, Murphy E, Molkentin JD. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest. 2010 Oct; 120(10):3680-7. PMID: 20890047.
      View in: PubMed
    54. Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 2010 Aug; 120(8):2805-16. PMID: 20644257.
      View in: PubMed
    55. Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res. 2010 Aug 20; 107(4):476-84. PMID: 20576936.
      View in: PubMed
    56. Miyamoto S, Del Re DP, Xiang SY, Zhao X, Florholmen G, Brown JH. Revisited and revised: is RhoA always a villain in cardiac pathophysiology? J Cardiovasc Transl Res. 2010 Aug; 3(4):330-43. PMID: 20559774.
      View in: PubMed
    57. Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res. 2010 Apr 16; 106(7):1265-74. PMID: 20203306.
      View in: PubMed
    58. Carretero-Ortega J, Walsh CT, Hernández-García R, Reyes-Cruz G, Brown JH, Vázquez-Prado J. Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. Mol Pharmacol. 2010 Mar; 77(3):435-42. PMID: 20018810.
      View in: PubMed
    59. Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown JH. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res. 2010 Feb 05; 106(2):354-62. PMID: 19959778.
      View in: PubMed
    60. Mani SK, Egan EA, Addy BK, Grimm M, Kasiganesan H, Thiyagarajan T, Renaud L, Brown JH, Kern CB, Menick DR. beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes. J Mol Cell Cardiol. 2010 Feb; 48(2):342-51. PMID: 19945464.
      View in: PubMed
    61. Grimm M, Brown JH. Beta-adrenergic receptor signaling in the heart: role of CaMKII. J Mol Cell Cardiol. 2010 Feb; 48(2):322-30. PMID: 19883653.
      View in: PubMed
    62. Catalucci D, Latronico MV, Ceci M, Rusconi F, Young HS, Gallo P, Santonastasi M, Bellacosa A, Brown JH, Condorelli G. Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17. J Biol Chem. 2009 Oct 09; 284(41):28180-7. PMID: 19696029.
      View in: PubMed
    63. Sag CM, Wadsack DP, Khabbazzadeh S, Abesser M, Grefe C, Neumann K, Opiela MK, Backs J, Olson EN, Brown JH, Neef S, Maier SK, Maier LS. Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure. Circ Heart Fail. 2009 Nov; 2(6):664-75. PMID: 19919992.
      View in: PubMed
    64. MacDonnell SM, Weisser-Thomas J, Kubo H, Hanscome M, Liu Q, Jaleel N, Berretta R, Chen X, Brown JH, Sabri AK, Molkentin JD, Houser SR. CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circ Res. 2009 Aug 14; 105(4):316-25. PMID: 19608982.
      View in: PubMed
    65. Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Brown JH, Heller Brown J. Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest. 2009 May; 119(5):1230-40. PMID: 19381018.
      View in: PubMed
    66. Miyamoto S, Murphy AN, Brown JH. Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J Bioenerg Biomembr. 2009 Apr; 41(2):169-80. PMID: 19377835.
      View in: PubMed
    67. Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown JH, Condorelli G. Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol. 2009 Mar 23; 184(6):923-33. PMID: 19307602.
      View in: PubMed
    68. Karliner JS, Brown JH. Lipid signalling in cardiovascular pathophysiology. Cardiovasc Res. 2009 May 01; 82(2):171-4. PMID: 19297369.
      View in: PubMed
    69. Means CK, Brown JH. Sphingosine-1-phosphate receptor signalling in the heart. Cardiovasc Res. 2009 May 01; 82(2):193-200. PMID: 19282351.
      View in: PubMed
    70. Rubio M, Avitabile D, Fischer K, Emmanuel G, Gude N, Miyamoto S, Mishra S, Schaefer EM, Brown JH, Sussman MA. Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. J Mol Cell Cardiol. 2009 Jul; 47(1):96-103. PMID: 19269295.
      View in: PubMed
    71. Diwan A, Matkovich SJ, Yuan Q, Zhao W, Yatani A, Brown JH, Molkentin JD, Kranias EG, Dorn GW. Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. J Clin Invest. 2009 Jan; 119(1):203-12. PMID: 19065046.
      View in: PubMed
    72. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. PMID: 19033658.
      View in: PubMed
    73. Del Re DP, Miyamoto S, Brown JH. Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J Biol Chem. 2008 Dec 19; 283(51):35622-9. PMID: 18854312.
      View in: PubMed
    74. Walsh CT, Radeff-Huang J, Matteo R, Hsiao A, Subramaniam S, Stupack D, Brown JH. Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61. FASEB J. 2008 Nov; 22(11):4011-21. PMID: 18687805.
      View in: PubMed
    75. Walsh CT, Stupack D, Brown JH. G protein-coupled receptors go extracellular: RhoA integrates the integrins. Mol Interv. 2008 Aug; 8(4):165-73. PMID: 18829842.
      View in: PubMed
    76. Haga JH, Kaunas R, Radeff-Huang J, Weems JM, Estrada KD, Chien S, Brown JH, Seasholtz TM. Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation. Biochem Biophys Res Commun. 2008 Jul 18; 372(1):216-20. PMID: 18474218.
      View in: PubMed
    77. Kaisaki PJ, Bergmann C, Brown JH, Outeda P, Lens XM, Peters DJ, Gretz N, Gauguier D, Bihoreau MT. Genomic organization and mutation screening of the human ortholog of Pkdr1 associated with polycystic kidney disease in the rat. Eur J Med Genet. 2008 Jul-Aug; 51(4):325-31. PMID: 18434273.
      View in: PubMed
    78. Means CK, Miyamoto S, Chun J, Brown JH. S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. J Biol Chem. 2008 May 02; 283(18):11954-63. PMID: 18296752.
      View in: PubMed
    79. Zhang T, Kohlhaas M, Backs J, Mishra S, Phillips W, Dybkova N, Chang S, Ling H, Bers DM, Maier LS, Olson EN, Brown JH. CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem. 2007 Nov 30; 282(48):35078-87. PMID: 17923476.
      View in: PubMed
    80. Citro S, Malik S, Oestreich EA, Radeff-Huang J, Kelley GG, Smrcka AV, Brown JH. Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15543-8. PMID: 17878312.
      View in: PubMed
    81. Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I, Chun J, Brown JH. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H2944-51. PMID: 17293497.
      View in: PubMed
    82. Del Re DP, Miyamoto S, Brown JH. RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. J Biol Chem. 2007 Mar 16; 282(11):8069-78. PMID: 17234627.
      View in: PubMed
    83. Maier LS, Bers DM, Brown JH. Calmodulin and Ca2+/calmodulin kinases in the heart - physiology and pathophysiology. Cardiovasc Res. 2007 Mar 01; 73(4):629-30. PMID: 17258179.
      View in: PubMed
    84. Wagner S, Dybkova N, Rasenack EC, Jacobshagen C, Fabritz L, Kirchhof P, Maier SK, Zhang T, Hasenfuss G, Brown JH, Bers DM, Maier LS. Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest. 2006 Dec; 116(12):3127-38. PMID: 17124532.
      View in: PubMed
    85. Radeff-Huang J, Seasholtz TM, Chang JW, Smith JM, Walsh CT, Brown JH. Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression. J Biol Chem. 2007 Jan 12; 282(2):863-70. PMID: 17114809.
      View in: PubMed
    86. Seasholtz TM, Wessel J, Rao F, Rana BK, Khandrika S, Kennedy BP, Lillie EO, Ziegler MG, Smith DW, Schork NJ, Brown JH, O'Connor DT. Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity. Hypertension. 2006 May; 47(5):937-47. PMID: 16585408.
      View in: PubMed
    87. Brown JH, Del Re DP, Sussman MA. The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ Res. 2006 Mar 31; 98(6):730-42. PMID: 16574914.
      View in: PubMed
    88. Wu X, Zhang T, Bossuyt J, Li X, McKinsey TA, Dedman JR, Olson EN, Chen J, Brown JH, Bers DM. Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest. 2006 Mar; 116(3):675-82. PMID: 16511602.
      View in: PubMed
    89. Howes AL, Miyamoto S, Adams JW, Woodcock EA, Brown JH. Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy. J Mol Cell Cardiol. 2006 May; 40(5):597-604. PMID: 16466740.
      View in: PubMed
    90. Kohlhaas M, Zhang T, Seidler T, Zibrova D, Dybkova N, Steen A, Wagner S, Chen L, Brown JH, Bers DM, Maier LS. Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res. 2006 Feb 03; 98(2):235-44. PMID: 16373600.
      View in: PubMed
    91. Brown JH, Bihoreau MT, Hoffmann S, Kränzlin B, Tychinskaya I, Obermüller N, Podlich D, Boehn SN, Kaisaki PJ, Megel N, Danoy P, Copley RR, Broxholme J, Witzgall R, Lathrop M, Gretz N, Gauguier D. Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat. J Am Soc Nephrol. 2005 Dec; 16(12):3517-26. PMID: 16207829.
      View in: PubMed
    92. Miyamoto S, Howes AL, Adams JW, Dorn GW, Brown JH. Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. J Biol Chem. 2005 Nov 18; 280(46):38505-12. PMID: 16061478.
      View in: PubMed
    93. Seasholtz TM, Brown JH. RHO SIGNALING in vascular diseases. Mol Interv. 2004 Dec; 4(6):348-57. PMID: 15616164.
      View in: PubMed
    94. Seasholtz TM, Radeff-Huang J, Sagi SA, Matteo R, Weems JM, Cohen AS, Feramisco JR, Brown JH. Rho-mediated cytoskeletal rearrangement in response to LPA is functionally antagonized by Rac1 and PIP2. J Neurochem. 2004 Oct; 91(2):501-12. PMID: 15447683.
      View in: PubMed
    95. Zhang T, Brown JH. Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure. Cardiovasc Res. 2004 Aug 15; 63(3):476-86. PMID: 15276473.
      View in: PubMed
    96. Radeff-Huang J, Seasholtz TM, Matteo RG, Brown JH. G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival. J Cell Biochem. 2004 Aug 01; 92(5):949-66. PMID: 15258918.
      View in: PubMed
    97. Hilal-Dandan R, Means CK, Gustafsson AB, Morissette MR, Adams JW, Brunton LL, Heller Brown J. Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. J Mol Cell Cardiol. 2004 Apr; 36(4):481-93. PMID: 15081308.
      View in: PubMed
    98. Zhang T, Miyamoto S, Brown JH. Cardiomyocyte calcium and calcium/calmodulin-dependent protein kinase II: friends or foes? Recent Prog Horm Res. 2004; 59:141-68. PMID: 14749501.
      View in: PubMed
    99. Hayakawa Y, Chandra M, Miao W, Shirani J, Brown JH, Dorn GW, Armstrong RC, Kitsis RN. Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice. Circulation. 2003 Dec 16; 108(24):3036-41. PMID: 14638549.
      View in: PubMed
    100. Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM. RGS16 inhibits signalling through the G alpha 13-Rho axis. Nat Cell Biol. 2003 Dec; 5(12):1095-103. PMID: 14634662.
      View in: PubMed
    101. Morissette MR, Howes AL, Zhang T, Heller Brown J. Upregulation of GLUT1 expression is necessary for hypertrophy and survival of neonatal rat cardiomyocytes. J Mol Cell Cardiol. 2003 Oct; 35(10):1217-27. PMID: 14519432.
      View in: PubMed
    102. Bayer AL, Heidkamp MC, Howes AL, Heller Brown J, Byron KL, Samarel AM. Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes. J Mol Cell Cardiol. 2003 Sep; 35(9):1121-33. PMID: 12967635.
      View in: PubMed
    103. Howes AL, Arthur JF, Zhang T, Miyamoto S, Adams JW, Dorn GW, Woodcock EA, Brown JH. Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. J Biol Chem. 2003 Oct 10; 278(41):40343-51. PMID: 12900409.
      View in: PubMed
    104. Kawamura S, Miyamoto S, Brown JH. Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation. J Biol Chem. 2003 Aug 15; 278(33):31111-7. PMID: 12777392.
      View in: PubMed
    105. Maier LS, Zhang T, Chen L, DeSantiago J, Brown JH, Bers DM. Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res. 2003 May 02; 92(8):904-11. PMID: 12676813.
      View in: PubMed
    106. Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J, Bers DM, Brown JH. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003 May 02; 92(8):912-9. PMID: 12676814.
      View in: PubMed
    107. Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kobilka BK, Cheng H, Xiao RP. Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J Clin Invest. 2003 Mar; 111(5):617-25. PMID: 12618516.
      View in: PubMed
    108. Pham TM, Morris JB, Arthur JF, Post GR, Brown JH, Woodcock EA. UTP but not ATP causes hypertrophic growth in neonatal rat cardiomyocytes. J Mol Cell Cardiol. 2003 Mar; 35(3):287-92. PMID: 12676543.
      View in: PubMed
    109. Petrich BG, Gong X, Lerner DL, Wang X, Brown JH, Saffitz JE, Wang Y. c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. Circ Res. 2002 Oct 04; 91(7):640-7. PMID: 12364393.
      View in: PubMed
    110. Contos JJ, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J. Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell Biol. 2002 Oct; 22(19):6921-9. PMID: 12215548.
      View in: PubMed
    111. Bihoreau MT, Megel N, Brown JH, Kränzlin B, Crombez L, Tychinskaya Y, Broxholme J, Kratz S, Bergmann V, Hoffman S, Gauguier D, Gretz N. Characterization of a major modifier locus for polycystic kidney disease (Modpkdr1) in the Han:SPRD(cy/+) rat in a region conserved with a mouse modifier locus for Alport syndrome. Hum Mol Genet. 2002 Sep 01; 11(18):2165-73. PMID: 12189169.
      View in: PubMed
    112. Ishii I, Ye X, Friedman B, Kawamura S, Contos JJ, Kingsbury MA, Yang AH, Zhang G, Brown JH, Chun J. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem. 2002 Jul 12; 277(28):25152-9. PMID: 12006579.
      View in: PubMed
    113. Woodcock EA, Wang BH, Arthur JF, Lennard A, Matkovich SJ, Du XJ, Brown JH, Hannan RD. Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor. J Biol Chem. 2002 Jun 21; 277(25):22734-42. PMID: 11932254.
      View in: PubMed
    114. Zhang T, Johnson EN, Gu Y, Morissette MR, Sah VP, Gigena MS, Belke DD, Dillmann WH, Rogers TB, Schulman H, Ross J, Brown JH. The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J Biol Chem. 2002 Jan 11; 277(2):1261-7. PMID: 11694533.
      View in: PubMed
    115. Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction. Annu Rev Pharmacol Toxicol. 2000; 40:459-89. PMID: 10836144.
      View in: PubMed