Joan Brown

Title(s)Recall Faculty, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.Albert Einstein College of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Cardiomyocyte CaM kinase II as a driver of cardiac inflammation and remodeling
    NIH R01HL145459Dec 15, 2018 - Nov 30, 2022
    Role: Principal Investigator
    RhoA and GPCR mediated transcriptional activation regulates glioblastoma
    NIH R01CA218859Feb 9, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Molecular Mechanism and Therapy for Ocular Melanoma
    NIH R01CA217642Mar 14, 2017 - Feb 28, 2023
    Role: Principal Investigator
    Restoring Mycocardial Healing
    NIH P01HL085577Jul 1, 2006 - Jul 31, 2018
    Role: Co-Investigator
    SAP KINASES IN GQ INDUCED APOPTOTIC HEART FAILURE
    NIH R01HL061505Sep 30, 1998 - Aug 31, 2003
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    RhoA mediated survival signals in cardiomyocytes
    NIH R37HL028143Aug 1, 1982 - Jan 31, 2021
    Role: Principal Investigator
    Rho- and GPCR-mediated signaling through novel cellular effectors
    NIH R01GM036927Aug 1, 1982 - Aug 31, 2014
    Role: Principal Investigator
    S1P, Rho and Akt signaling in cardiomyocyte survival
    NIH R01HL028143Aug 1, 1982 - Mar 31, 2010
    Role: Principal Investigator
    Rho- and GPCR-mediated signaling through novel cellular effectors
    NIH R56GM036927Aug 1, 1982 - Aug 31, 2009
    Role: Principal Investigator
    Graduate Training in Cellular and Molecular Pharmacology
    NIH T32GM007752Jul 1, 1979 - Jun 30, 2024
    Role: Principal Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH P01HL046345Jun 30, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ca2+/calmodulin-dependent kinase IIδC-induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak. ESC Heart Fail. 2024 Aug; 11(4):2191-2199. Dewenter M, Seitz T, Steinbrecher JH, Westenbrink BD, Ling H, Lehnart SE, Wehrens XHT, Backs J, Brown JH, Maier LS, Neef S. PMID: 38616546; PMCID: PMC11287324.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion. Sci Rep. 2023 12 16; 13(1):22412. Chaim OM, Miki S, Prager BC, Ma J, Jeong AY, Lara J, Tran NK, Smith JM, Rich JN, Gutkind JS, Miyamoto S, Furnari FB, Brown JH. PMID: 38104152; PMCID: PMC10725435.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Nitric Oxide modulates spontaneous Ca2+ release and ventricular arrhythmias during β-adrenergic signalling through S-nitrosylation of Calcium/Calmodulin dependent kinase II. bioRxiv. 2023 Aug 24. Power AS, Asamudo E, Worthington LPI, Alim CC, Parackal R, Wallace RS, Ebenebe OV, Brown JH, Kohr MJ, Bers DM, Erickson JR. PMID: 37662205; PMCID: PMC10473710.
      View in: PubMed   Mentions:
    4. RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria. Cell Death Differ. 2022 12; 29(12):2472-2486. Tu M, Tan VP, Yu JD, Tripathi R, Bigham Z, Barlow M, Smith JM, Brown JH, Miyamoto S. PMID: 35760846; PMCID: PMC9751115.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    5. Splicing and Dicing: A Deeper Dive Into CaMKIIδ and Cardiac Inflammation. Circ Res. 2022 03 18; 130(6):904-906. Brown JH, Miyamoto S. PMID: 35298299; PMCID: PMC8944245.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence. Mol Oncol. 2022 02; 16(3):607-629. Yu L, Zhou D, Zhang G, Ren Z, Luo X, Liu P, Plouffe SW, Meng Z, Moroishi T, Li Y, Zhang Y, Brown JH, Liu S, Guan KL. PMID: 34706158; PMCID: PMC8807356.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    7. The contribution of the cardiomyocyte to tissue inflammation in cardiomyopathies. Curr Opin Physiol. 2021 Feb; 19:129-134. Ninh VK, Brown JH. PMID: 35005327; PMCID: PMC8730355.
      View in: PubMed   Mentions: 6  
    8. CaMKIIδC Drives Early Adaptive Ca2+ Change and Late Eccentric Cardiac Hypertrophy. Circ Res. 2020 10 09; 127(9):1159-1178. Ljubojevic-Holzer S, Herren AW, Djalinac N, Voglhuber J, Morotti S, Holzer M, Wood BM, Abdellatif M, Matzer I, Sacherer M, Radulovic S, Wallner M, Ivanov M, Wagner S, Sossalla S, von Lewinski D, Pieske B, Brown JH, Sedej S, Bossuyt J, Bers DM. PMID: 32821022; PMCID: PMC7547876.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    9. Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling. Am J Physiol Heart Circ Physiol. 2019 11 01; 317(5):H877-H890. Suetomi T, Miyamoto S, Brown JH. PMID: 31441689; PMCID: PMC6879920.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    10. Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca2+/Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling. Circulation. 2018 11 27; 138(22):2530-2544. Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S, Brown JH. PMID: 30571348; PMCID: PMC6309790.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    11. RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes. Cell Signal. 2018 Oct; 50:48-57. Brand CS, Tan VP, Brown JH, Miyamoto S. PMID: 29953931; PMCID: PMC6361616.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    12. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. PMID: 29887596; PMCID: PMC6195840.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    13. Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Physiol Regul Integr Comp Physiol. 2018 06 01; 314(6):R834-R847. Crotty Alexander LE, Drummond CA, Hepokoski M, Mathew D, Moshensky A, Willeford A, Das S, Singh P, Yong Z, Lee JH, Vega K, Du A, Shin J, Javier C, Tian J, Brown JH, Breen EC. PMID: 29384700; PMCID: PMC6032308.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimals
    14. Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes. J Neuroinflammation. 2017 06 02; 14(1):111. Dusaban SS, Chun J, Rosen H, Purcell NH, Brown JH. PMID: 28577576; PMCID: PMC5455202.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    15. Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure. Circ Heart Fail. 2017 May; 10(5):e003840. Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A. PMID: 28487342; PMCID: PMC5479434.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    16. CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α. J Mol Cell Cardiol. 2017 02; 103:48-55. Gray CB, Suetomi T, Xiang S, Mishra S, Blackwood EA, Glembotski CC, Miyamoto S, Westenbrink BD, Brown JH. PMID: 28077321; PMCID: PMC5564300.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    17. Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. J Mol Cell Cardiol. 2017 02; 103:1-10. Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell NH, Brown JH, Miyamoto S. PMID: 28017639; PMCID: PMC5410967.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    18. Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+ homeostasis. J Appl Physiol (1985). 2016 07 01; 121(1):212-20. Høydal MA, Stølen TO, Kettlewell S, Maier LS, Brown JH, Sowa T, Catalucci D, Condorelli G, Kemi OJ, Smith GL, Wisløff U. PMID: 27231311; PMCID: PMC4967256.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    19. Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. Cell Signal. 2016 08; 28(8):871-9. Castaldi A, Chesini GP, Taylor AE, Sussman MA, Brown JH, Purcell NH. PMID: 27094722; PMCID: PMC5004781.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    20. Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload. Circulation. 2016 Mar 29; 133(13):1225-7. Miyamoto S, Brown JH. PMID: 26915632; PMCID: PMC4811683.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    21. Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic β-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor κB. J Biol Chem. 2016 Feb 19; 291(8):4156-65. Panama BK, Korogyi AS, Aschar-Sobbi R, Oh Y, Gray CB, Gang H, Brown JH, Kirshenbaum LA, Backx PH. PMID: 26742842; PMCID: PMC4759190.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    22. Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. Mol Pharmacol. 2016 Jan; 89(1):176-86. Sanna MG, Vincent KP, Repetto E, Nguyen N, Brown SJ, Abgaryan L, Riley SW, Leaf NB, Cahalan SM, Kiosses WB, Kohno Y, Brown JH, McCulloch AD, Rosen H, Gonzalez-Cabrera PJ. PMID: 26494861; PMCID: PMC4702096.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    23. Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation. Mol Cell Biol. 2016 Jan 01; 36(1):39-49. Yu OM, Miyamoto S, Brown JH. PMID: 26459764; PMCID: PMC4702594.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    24. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase Cϵ. J Biol Chem. 2015 Oct 30; 290(44):26776-83. Dusaban SS, Kunkel MT, Smrcka AV, Brown JH. PMID: 26350460; PMCID: PMC4646330.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91. Grimm M, Ling H, Willeford A, Pereira L, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers DM, Brown JH. PMID: 26080362; PMCID: PMC4530053.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    26. The First 50 Years of Molecular Pharmacology. Mol Pharmacol. 2015 Jul; 88(1):139-40. Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF. PMID: 25943115.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    27. G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation. Mol Pharmacol. 2015 Jul; 88(1):171-80. Yu OM, Brown JH. PMID: 25904553; PMCID: PMC4468647.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    28. Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39. Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. . PMID: 25605649; PMCID: PMC4344921.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    29. CaMKII confirms its promise in ischaemic heart disease. Eur J Heart Fail. 2014 Dec; 16(12):1268-9. van Oort RJ, Brown JH, Westenbrink BD. PMID: 25452163.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. PLCε mediated sustained signaling pathways. Adv Biol Regul. 2015 Jan; 57:17-23. Dusaban SS, Brown JH. PMID: 25453218; PMCID: PMC4314097.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    31. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. PMID: 25236710; PMCID: PMC4301603.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    32. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. J Mol Cell Cardiol. 2014 Oct; 75:152-61. Zhao X, Ding EY, Yu OM, Xiang SY, Tan-Sah VP, Yung BS, Hedgpeth J, Neubig RR, Lau LF, Brown JH, Miyamoto S. PMID: 25106095; PMCID: PMC4157956.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    33. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2014 Sep; 74:274-83. Di Carlo MN, Said M, Ling H, Valverde CA, De Giusti VC, Sommese L, Palomeque J, Aiello EA, Skapura DG, Rinaldi G, Respress JL, Brown JH, Wehrens XH, Salas MA, Mattiazzi A. PMID: 24949568; PMCID: PMC4131282.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    34. In vivo selective expression of thyroid hormone receptor α1 in endothelial cells attenuates myocardial injury in experimental myocardial infarction in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Aug 01; 307(3):R340-6. Suarez J, Wang H, Scott BT, Ling H, Makino A, Swanson E, Brown JH, Suarez JA, Feinstein S, Diaz-Juarez J, Dillmann WH. PMID: 24848360; PMCID: PMC4121632.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    35. The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. J Biol Chem. 2014 Jun 20; 289(25):17689-98. Sayyah J, Bartakova A, Nogal N, Quilliam LA, Stupack DG, Brown JH. PMID: 24790104; PMCID: PMC4067203.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    36. CaMKIIdelta subtypes: localization and function. Front Pharmacol. 2014; 5:15. Gray CB, Heller Brown J. . PMID: 24575042; PMCID: PMC3920101.
      View in: PubMed   Mentions: 43  
    37. A new non-canonical pathway of Gα(q) protein regulating mitochondrial dynamics and bioenergetics. Cell Signal. 2014 May; 26(5):1135-46. Benincá C, Planagumà J, de Freitas Shuck A, Acín-Perez R, Muñoz JP, de Almeida MM, Brown JH, Murphy AN, Zorzano A, Enríquez JA, Aragay AM. PMID: 24444709; PMCID: PMC4745894.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    38. PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. Sci Signal. 2013 Dec 17; 6(306):ra108. Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Heller Brown J. . PMID: 24345679; PMCID: PMC4035240.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    39. Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. J Physiol. 2014 Mar 01; 592(5):971-90. Zhang DM, Chai Y, Erickson JR, Brown JH, Bers DM, Lin YF. PMID: 24277866; PMCID: PMC3948558.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    40. The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias. Expert Opin Ther Targets. 2013 Aug; 17(8):889-903. Westenbrink BD, Edwards AG, McCulloch AD, Brown JH. PMID: 23789646; PMCID: PMC5551677.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    41. Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3609-14. Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, Brown JH. PMID: 23401561; PMCID: PMC3587233.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    42. Ca2+/Calmodulin-dependent protein kinase II δ mediates myocardial ischemia/reperfusion injury through nuclear factor-κB. Circ Res. 2013 Mar 15; 112(6):935-44. Ling H, Gray CB, Zambon AC, Grimm M, Gu Y, Dalton N, Purcell NH, Peterson K, Brown JH. PMID: 23388157; PMCID: PMC3673710.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    43. Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22. Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM. PMID: 23363625; PMCID: PMC3690126.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    44. PHLPP1 gene deletion protects the brain from ischemic injury. J Cereb Blood Flow Metab. 2013 Feb; 33(2):196-204. Chen B, Van Winkle JA, Lyden PD, Brown JH, Purcell NH. PMID: 23072745; PMCID: PMC3564187.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    45. Lysophospholipid receptor activation of RhoA and lipid signaling pathways. Biochim Biophys Acta. 2013 Jan; 1831(1):213-22. Xiang SY, Dusaban SS, Brown JH. PMID: 22986288; PMCID: PMC4076288.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    46. Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev. 2012 Oct 01; 26(19):2138-43. Mo JS, Yu FX, Gong R, Brown JH, Guan KL. PMID: 22972936; PMCID: PMC3465735.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansCells
    47. APJ acts as a dual receptor in cardiac hypertrophy. Nature. 2012 Aug 16; 488(7411):394-8. Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE, Purcell NH, Catalucci D, Akasaka T, Bueno OF, Vlasuk GP, Kaliman P, Bodmer R, Smith LH, Ashley E, Mercola M, Brown JH, Ruiz-Lozano P. PMID: 22810587; PMCID: PMC3422434.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    48. Identification of potential small molecule binding pockets on Rho family GTPases. PLoS One. 2012; 7(7):e40809. Ortiz-Sanchez JM, Nichols SE, Sayyah J, Brown JH, McCammon JA, Grant BJ. PMID: 22815826; PMCID: PMC3397943.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    49. CaMKIIδC slows [Ca]i decline in cardiac myocytes by promoting Ca sparks. Biophys J. 2012 Jun 06; 102(11):2461-70. Guo T, Zhang T, Ginsburg KS, Mishra S, Brown JH, Bers DM. PMID: 22713561; PMCID: PMC3368151.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    50. Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cell Signal. 2012 Jun; 24(6):1333-43. Smrcka AV, Brown JH, Holz GG. PMID: 22286105; PMCID: PMC3325758.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    51. Novel allosteric sites on Ras for lead generation. PLoS One. 2011; 6(10):e25711. Grant BJ, Lukman S, Hocker HJ, Sayyah J, Brown JH, McCammon JA, Gorfe AA. PMID: 22046245; PMCID: PMC3201956.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    52. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res. 2011 Dec 09; 109(12):1354-62. Mishra S, Gray CB, Miyamoto S, Bers DM, Brown JH. PMID: 21998325; PMCID: PMC3241507.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    53. RhoA protects the mouse heart against ischemia/reperfusion injury. J Clin Invest. 2011 Aug; 121(8):3269-76. Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, Brown JH. PMID: 21747165; PMCID: PMC3148727.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    54. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res. 2011 Jul 08; 109(2):141-50. Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J. PMID: 21597010; PMCID: PMC3132348.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    55. Crossing signals: relationships between β-adrenergic stimulation and CaMKII activation. Heart Rhythm. 2011 Aug; 8(8):1296-8. Grimm M, Ling H, Brown JH. PMID: 21354330; PMCID: PMC3153445.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    56. CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol. 2011 Oct; 51(4):468-73. Anderson ME, Brown JH, Bers DM. PMID: 21276796; PMCID: PMC3158288.
      View in: PubMed   Mentions: 250     Fields:    Translation:HumansAnimalsCells
    57. Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality. J Am Coll Cardiol. 2011 Jan 25; 57(4):469-79. Dybkova N, Sedej S, Napolitano C, Neef S, Rokita AG, Hünlich M, Brown JH, Kockskämper J, Priori SG, Pieske B, Maier LS. PMID: 21251589.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    58. Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Eur Heart J. 2011 Sep; 32(17):2179-88. Cheng Z, Völkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA. PMID: 21228009; PMCID: PMC3164102.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    59. Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling. J Cardiovasc Pharmacol. 2010 Dec; 56(6):598-603. Mishra S, Ling H, Grimm M, Zhang T, Bers DM, Brown JH. PMID: 20531218; PMCID: PMC2947575.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    60. SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC. J Mol Cell Cardiol. 2011 Jan; 50(1):230-8. Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers DM. PMID: 20971119; PMCID: PMC3018844.
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    61. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest. 2010 Oct; 120(10):3680-7. Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown JH, Murphy E, Molkentin JD. PMID: 20890047; PMCID: PMC2947235.
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    62. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 2010 Aug; 120(8):2805-16. Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G. PMID: 20644257; PMCID: PMC2912201.
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    63. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res. 2010 Aug 20; 107(4):476-84. Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PMID: 20576936; PMCID: PMC2957297.
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    64. Revisited and revised: is RhoA always a villain in cardiac pathophysiology? J Cardiovasc Transl Res. 2010 Aug; 3(4):330-43. Miyamoto S, Del Re DP, Xiang SY, Zhao X, Florholmen G, Brown JH. PMID: 20559774; PMCID: PMC3005405.
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    65. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res. 2010 Apr 16; 106(7):1265-74. Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA. PMID: 20203306; PMCID: PMC2864233.
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    66. Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. Mol Pharmacol. 2010 Mar; 77(3):435-42. Carretero-Ortega J, Walsh CT, Hernández-García R, Reyes-Cruz G, Brown JH, Vázquez-Prado J. PMID: 20018810; PMCID: PMC3202486.
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    67. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res. 2010 Feb 05; 106(2):354-62. Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown JH. PMID: 19959778; PMCID: PMC2818826.
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    68. beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes. J Mol Cell Cardiol. 2010 Feb; 48(2):342-51. Mani SK, Egan EA, Addy BK, Grimm M, Kasiganesan H, Thiyagarajan T, Renaud L, Brown JH, Kern CB, Menick DR. PMID: 19945464; PMCID: PMC3624970.
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    69. Beta-adrenergic receptor signaling in the heart: role of CaMKII. J Mol Cell Cardiol. 2010 Feb; 48(2):322-30. Grimm M, Brown JH. PMID: 19883653; PMCID: PMC2896283.
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    70. Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17. J Biol Chem. 2009 Oct 09; 284(41):28180-28187. Catalucci D, Latronico MVG, Ceci M, Rusconi F, Young HS, Gallo P, Santonastasi M, Bellacosa A, Brown JH, Condorelli G. PMID: 19696029; PMCID: PMC2788869.
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    71. Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure. Circ Heart Fail. 2009 Nov; 2(6):664-75. Sag CM, Wadsack DP, Khabbazzadeh S, Abesser M, Grefe C, Neumann K, Opiela MK, Backs J, Olson EN, Brown JH, Neef S, Maier SK, Maier LS. PMID: 19919992; PMCID: PMC2835502.
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    72. CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circ Res. 2009 Aug 14; 105(4):316-25. MacDonnell SM, Weisser-Thomas J, Kubo H, Hanscome M, Liu Q, Jaleel N, Berretta R, Chen X, Brown JH, Sabri AK, Molkentin JD, Houser SR. PMID: 19608982; PMCID: PMC2765687.
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    73. Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest. 2009 May; 119(5):1230-40. Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Brown JH, Heller Brown J. PMID: 19381018; PMCID: PMC2673879.
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    74. Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J Bioenerg Biomembr. 2009 Apr; 41(2):169-80. Miyamoto S, Murphy AN, Brown JH. PMID: 19377835; PMCID: PMC2732429.
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    75. Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol. 2009 Mar 23; 184(6):923-33. Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers DM, Brown JH, Condorelli G. PMID: 19307602; PMCID: PMC2699149.
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    76. Lipid signalling in cardiovascular pathophysiology. Cardiovasc Res. 2009 May 01; 82(2):171-4. Karliner JS, Brown JH. PMID: 19297369.
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    77. Sphingosine-1-phosphate receptor signalling in the heart. Cardiovasc Res. 2009 May 01; 82(2):193-200. Means CK, Brown JH. PMID: 19282351; PMCID: PMC2721649.
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    78. Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. J Mol Cell Cardiol. 2009 Jul; 47(1):96-103. Rubio M, Avitabile D, Fischer K, Emmanuel G, Gude N, Miyamoto S, Mishra S, Schaefer EM, Brown JH, Sussman MA. PMID: 19269295; PMCID: PMC2692628.
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    79. Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. J Clin Invest. 2009 Jan; 119(1):203-12. Diwan A, Matkovich SJ, Yuan Q, Zhao W, Yatani A, Brown JH, Molkentin JD, Kranias EG, Dorn GW. PMID: 19065046; PMCID: PMC2613462.
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    80. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. PMID: 19033658; PMCID: PMC2575833.
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    81. Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. J Biol Chem. 2008 Dec 19; 283(51):35622-9. Del Re DP, Miyamoto S, Brown JH. PMID: 18854312; PMCID: PMC2602897.
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    82. Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61. FASEB J. 2008 Nov; 22(11):4011-21. Walsh CT, Radeff-Huang J, Matteo R, Hsiao A, Subramaniam S, Stupack D, Brown JH. PMID: 18687805; PMCID: PMC3980657.
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    83. G protein-coupled receptors go extracellular: RhoA integrates the integrins. Mol Interv. 2008 Aug; 8(4):165-73. Walsh CT, Stupack D, Brown JH. PMID: 18829842; PMCID: PMC2637220.
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    84. Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation. Biochem Biophys Res Commun. 2008 Jul 18; 372(1):216-20. Haga JH, Kaunas R, Radeff-Huang J, Weems JM, Estrada KD, Chien S, Brown JH, Seasholtz TM. PMID: 18474218; PMCID: PMC2587448.
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    85. Genomic organization and mutation screening of the human ortholog of Pkdr1 associated with polycystic kidney disease in the rat. Eur J Med Genet. 2008 Jul-Aug; 51(4):325-31. Kaisaki PJ, Bergmann C, Brown JH, Outeda P, Lens XM, Peters DJ, Gretz N, Gauguier D, Bihoreau MT. PMID: 18434273.
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    86. S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. J Biol Chem. 2008 May 02; 283(18):11954-63. Means CK, Miyamoto S, Chun J, Brown JH. PMID: 18296752; PMCID: PMC2335351.
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    87. CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem. 2007 Nov 30; 282(48):35078-87. Zhang T, Kohlhaas M, Backs J, Mishra S, Phillips W, Dybkova N, Chang S, Ling H, Bers DM, Maier LS, Olson EN, Brown JH. PMID: 17923476.
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    88. Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15543-8. Citro S, Malik S, Oestreich EA, Radeff-Huang J, Kelley GG, Smrcka AV, Brown JH. PMID: 17878312; PMCID: PMC2000505.
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    89. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H2944-51. Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I, Chun J, Brown JH. PMID: 17293497.
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    90. RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. J Biol Chem. 2007 Mar 16; 282(11):8069-78. Del Re DP, Miyamoto S, Brown JH. PMID: 17234627.
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    91. Calmodulin and Ca2+/calmodulin kinases in the heart - physiology and pathophysiology. Cardiovasc Res. 2007 Mar 01; 73(4):629-30. Maier LS, Bers DM, Brown JH. PMID: 17258179.
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    92. Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest. 2006 Dec; 116(12):3127-38. Wagner S, Dybkova N, Rasenack EC, Jacobshagen C, Fabritz L, Kirchhof P, Maier SK, Zhang T, Hasenfuss G, Brown JH, Bers DM, Maier LS. PMID: 17124532; PMCID: PMC1654201.
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    93. Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression. J Biol Chem. 2007 Jan 12; 282(2):863-70. Radeff-Huang J, Seasholtz TM, Chang JW, Smith JM, Walsh CT, Brown JH. PMID: 17114809.
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    94. Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity. Hypertension. 2006 May; 47(5):937-47. Seasholtz TM, Wessel J, Rao F, Rana BK, Khandrika S, Kennedy BP, Lillie EO, Ziegler MG, Smith DW, Schork NJ, Brown JH, O'Connor DT. PMID: 16585408.
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    95. The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ Res. 2006 Mar 31; 98(6):730-42. Brown JH, Del Re DP, Sussman MA. PMID: 16574914.
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    96. Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest. 2006 Mar; 116(3):675-82. Wu X, Zhang T, Bossuyt J, Li X, McKinsey TA, Dedman JR, Olson EN, Chen J, Brown JH, Bers DM. PMID: 16511602; PMCID: PMC1386110.
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    97. Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy. J Mol Cell Cardiol. 2006 May; 40(5):597-604. Howes AL, Miyamoto S, Adams JW, Woodcock EA, Brown JH. PMID: 16466740.
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    98. Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res. 2006 Feb 03; 98(2):235-44. Kohlhaas M, Zhang T, Seidler T, Zibrova D, Dybkova N, Steen A, Wagner S, Chen L, Brown JH, Bers DM, Maier LS. PMID: 16373600.
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    99. Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat. J Am Soc Nephrol. 2005 Dec; 16(12):3517-26. Brown JH, Bihoreau MT, Hoffmann S, Kränzlin B, Tychinskaya I, Obermüller N, Podlich D, Boehn SN, Kaisaki PJ, Megel N, Danoy P, Copley RR, Broxholme J, Witzgall R, Lathrop M, Gretz N, Gauguier D. PMID: 16207829.
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    100. Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. J Biol Chem. 2005 Nov 18; 280(46):38505-12. Miyamoto S, Howes AL, Adams JW, Dorn GW, Brown JH. PMID: 16061478.
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    101. RHO SIGNALING in vascular diseases. Mol Interv. 2004 Dec; 4(6):348-57. Seasholtz TM, Brown JH. PMID: 15616164.
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    102. Rho-mediated cytoskeletal rearrangement in response to LPA is functionally antagonized by Rac1 and PIP2. J Neurochem. 2004 Oct; 91(2):501-12. Seasholtz TM, Radeff-Huang J, Sagi SA, Matteo R, Weems JM, Cohen AS, Feramisco JR, Brown JH. PMID: 15447683.
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    103. Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure. Cardiovasc Res. 2004 Aug 15; 63(3):476-86. Zhang T, Brown JH. PMID: 15276473.
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    104. G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival. J Cell Biochem. 2004 Aug 01; 92(5):949-66. Radeff-Huang J, Seasholtz TM, Matteo RG, Brown JH. PMID: 15258918.
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    105. Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. J Mol Cell Cardiol. 2004 Apr; 36(4):481-93. Hilal-Dandan R, Means CK, Gustafsson AB, Morissette MR, Adams JW, Brunton LL, Heller Brown J. . PMID: 15081308.
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    106. Cardiomyocyte calcium and calcium/calmodulin-dependent protein kinase II: friends or foes? Recent Prog Horm Res. 2004; 59:141-68. Zhang T, Miyamoto S, Brown JH. PMID: 14749501.
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    107. Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice. Circulation. 2003 Dec 16; 108(24):3036-41. Hayakawa Y, Chandra M, Miao W, Shirani J, Brown JH, Dorn GW, Armstrong RC, Kitsis RN. PMID: 14638549.
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    108. RGS16 inhibits signalling through the G alpha 13-Rho axis. Nat Cell Biol. 2003 Dec; 5(12):1095-103. Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM. PMID: 14634662.
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    109. Upregulation of GLUT1 expression is necessary for hypertrophy and survival of neonatal rat cardiomyocytes. J Mol Cell Cardiol. 2003 Oct; 35(10):1217-27. Morissette MR, Howes AL, Zhang T, Heller Brown J. . PMID: 14519432.
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    110. Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes. J Mol Cell Cardiol. 2003 Sep; 35(9):1121-33. Bayer AL, Heidkamp MC, Howes AL, Heller Brown J, Byron KL, Samarel AM. PMID: 12967635.
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    111. Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. J Biol Chem. 2003 Oct 10; 278(41):40343-51. Howes AL, Arthur JF, Zhang T, Miyamoto S, Adams JW, Dorn GW, Woodcock EA, Brown JH. PMID: 12900409.
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    112. Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation. J Biol Chem. 2003 Aug 15; 278(33):31111-7. Kawamura S, Miyamoto S, Brown JH. PMID: 12777392.
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    113. Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res. 2003 May 02; 92(8):904-11. Maier LS, Zhang T, Chen L, DeSantiago J, Brown JH, Bers DM. PMID: 12676813.
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    114. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003 May 02; 92(8):912-9. Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J, Bers DM, Brown JH. PMID: 12676814.
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    115. Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J Clin Invest. 2003 Mar; 111(5):617-25. Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kobilka BK, Cheng H, Xiao RP. PMID: 12618516; PMCID: PMC151893.
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    116. UTP but not ATP causes hypertrophic growth in neonatal rat cardiomyocytes. J Mol Cell Cardiol. 2003 Mar; 35(3):287-92. Pham TM, Morris JB, Arthur JF, Post GR, Brown JH, Woodcock EA. PMID: 12676543.
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    117. c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. Circ Res. 2002 Oct 04; 91(7):640-7. Petrich BG, Gong X, Lerner DL, Wang X, Brown JH, Saffitz JE, Wang Y. PMID: 12364393.
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    118. Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell Biol. 2002 Oct; 22(19):6921-9. Contos JJ, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J. PMID: 12215548; PMCID: PMC134025.
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    119. Characterization of a major modifier locus for polycystic kidney disease (Modpkdr1) in the Han:SPRD(cy/+) rat in a region conserved with a mouse modifier locus for Alport syndrome. Hum Mol Genet. 2002 Sep 01; 11(18):2165-73. Bihoreau MT, Megel N, Brown JH, Kränzlin B, Crombez L, Tychinskaya Y, Broxholme J, Kratz S, Bergmann V, Hoffman S, Gauguier D, Gretz N. PMID: 12189169.
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    120. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem. 2002 Jul 12; 277(28):25152-9. Ishii I, Ye X, Friedman B, Kawamura S, Contos JJ, Kingsbury MA, Yang AH, Zhang G, Brown JH, Chun J. PMID: 12006579.
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    121. Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor. J Biol Chem. 2002 Jun 21; 277(25):22734-42. Woodcock EA, Wang BH, Arthur JF, Lennard A, Matkovich SJ, Du XJ, Brown JH, Hannan RD. PMID: 11932254.
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    122. The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J Biol Chem. 2002 Jan 11; 277(2):1261-7. Zhang T, Johnson EN, Gu Y, Morissette MR, Sah VP, Gigena MS, Belke DD, Dillmann WH, Rogers TB, Schulman H, Ross J, Brown JH. PMID: 11694533.
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    123. The role of Rho in G protein-coupled receptor signal transduction. Annu Rev Pharmacol Toxicol. 2000; 40:459-89. Sah VP, Seasholtz TM, Sagi SA, Brown JH. PMID: 10836144.
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