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Joan Heller Brown

Title(s)Distinguished Professor and Department Chair, Pharmacology
SchoolHealth Sciences
Address9500 Gilman Drive #0636
La Jolla CA 92093
Phone858-534-2595
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.Albert Einstein College of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Cardiomyocyte CaM kinase II as a driver of cardiac inflammation and remodeling
    NIH/NHLBI R01HL145459Dec 15, 2018 - Nov 30, 2022
    Role: Principal Investigator
    RhoA and GPCR mediated transcriptional activation regulates glioblastoma
    NIH/NCI R01CA218859Feb 9, 2018 - Jan 31, 2023
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Aug 13, 2009 - Mar 31, 2014
    Role: Co-Investigator
    Restoring Mycocardial Healing
    NIH P01HL085577Jul 1, 2006 - Jul 31, 2018
    Role: Co-Investigator
    SAP KINASES IN GQ INDUCED APOPTOTIC HEART FAILURE
    NIH/NHLBI R01HL061505Sep 30, 1998 - Sep 29, 2002
    Role: Principal Investigator
    Molecular Pathways for Hypertrophy and Cardiomyopathy
    NIH/NHLBI P01HL046345Feb 1, 1992 - Sep 30, 1997
    Role: Co-Investigator
    RhoA mediated survival signals in cardiomyocytes
    NIH/NHLBI R37HL028143Aug 1, 1982 - Mar 31, 2015
    Role: Principal Investigator
    S1P, Rho and Akt signaling in cardiomyocyte survival
    NIH/NHLBI R01HL028143Aug 1, 1982 - Mar 31, 2010
    Role: Principal Investigator
    Rho- and GPCR-mediated signaling through novel cellular effectors
    NIH/NIGMS R56GM036927Aug 1, 1982 - Aug 31, 2009
    Role: Principal Investigator
    Rho- and GPCR-mediated signaling through novel cellular effectors
    NIH/NIGMS R01GM036927Aug 1, 1982 - Nov 30, 2007
    Role: Principal Investigator
    Graduate Training in Cellular and Molecular Pharmacology
    NIH/NIGMS T32GM007752Jul 1, 1979 - Jun 30, 2024
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inflammation in nonischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling. Am J Physiol Heart Circ Physiol. 2019 11 01; 317(5):H877-H890. Suetomi T, Miyamoto S, Brown JH. PMID: 31441689.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    2. Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca2+/Calmodulin-Dependent Protein Kinase II d Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling. Circulation. 2018 11 27; 138(22):2530-2544. Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S, Brown JH. PMID: 30571348.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    3. RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes. Cell Signal. 2018 Oct; 50:48-57. Brand CS, Tan VP, Brown JH, Miyamoto S. PMID: 29953931.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    4. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018 10; 37(41):5492-5507. Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. PMID: 29887596.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    5. Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Physiol Regul Integr Comp Physiol. 2018 06 01; 314(6):R834-R847. Crotty Alexander LE, Drummond CA, Hepokoski M, Mathew D, Moshensky A, Willeford A, Das S, Singh P, Yong Z, Lee JH, Vega K, Du A, Shin J, Javier C, Tian J, Brown JH, Breen EC. PMID: 29384700.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    6. Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes. J Neuroinflammation. 2017 06 02; 14(1):111. Dusaban SS, Chun J, Rosen H, Purcell NH, Brown JH. PMID: 28577576.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    7. Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic ß-Adrenoceptor Blockade in Experimental and Human Heart Failure. Circ Heart Fail. 2017 May; 10(5):e003840. Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A. PMID: 28487342.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    8. CaMKIId subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-?B and TNF-a. J Mol Cell Cardiol. 2017 02; 103:48-55. Gray CB, Suetomi T, Xiang S, Mishra S, Blackwood EA, Glembotski CC, Miyamoto S, Westenbrink BD, Brown JH. PMID: 28077321.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    9. Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. J Mol Cell Cardiol. 2017 02; 103:1-10. Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell NH, Brown JH, Miyamoto S. PMID: 28017639.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    10. Exercise training reverses myocardial dysfunction induced by CaMKIIdC overexpression by restoring Ca2+ homeostasis. J Appl Physiol (1985). 2016 07 01; 121(1):212-20. Høydal MA, Stølen TO, Kettlewell S, Maier LS, Brown JH, Sowa T, Catalucci D, Condorelli G, Kemi OJ, Smith GL, Wisløff U. PMID: 27231311.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. Cell Signal. 2016 08; 28(8):871-9. Castaldi A, Chesini GP, Taylor AE, Sussman MA, Brown JH, Purcell NH. PMID: 27094722.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload. Circulation. 2016 Mar 29; 133(13):1225-7. Miyamoto S, Brown JH. PMID: 26915632.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic ß-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor ?B. J Biol Chem. 2016 Feb 19; 291(8):4156-65. Panama BK, Korogyi AS, Aschar-Sobbi R, Oh Y, Gray CB, Gang H, Brown JH, Kirshenbaum LA, Backx PH. PMID: 26742842.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    14. Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. Mol Pharmacol. 2016 Jan; 89(1):176-86. Sanna MG, Vincent KP, Repetto E, Nguyen N, Brown SJ, Abgaryan L, Riley SW, Leaf NB, Cahalan SM, Kiosses WB, Kohno Y, Brown JH, McCulloch AD, Rosen H, Gonzalez-Cabrera PJ. PMID: 26494861.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    15. Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation. Mol Cell Biol. 2016 Jan 01; 36(1):39-49. Yu OM, Miyamoto S, Brown JH. PMID: 26459764.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    16. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C?. J Biol Chem. 2015 Oct 30; 290(44):26776-83. Dusaban SS, Kunkel MT, Smrcka AV, Brown JH. PMID: 26350460.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    17. CaMKIId mediates ß-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ß-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91. Grimm M, Ling H, Willeford A, Pereira L, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers DM, Brown JH. PMID: 26080362.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    18. The First 50 Years of Molecular Pharmacology. Mol Pharmacol. 2015 Jul; 88(1):139-40. Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF. PMID: 25943115.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    19. G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation. Mol Pharmacol. 2015 Jul; 88(1):171-80. Yu OM, Brown JH. PMID: 25904553.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    20. Mitochondrial reprogramming induced by CaMKIId mediates hypertrophy decompensation. Circ Res. 2015 Feb 27; 116(5):e28-39. Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. PMID: 25605649.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    21. CaMKII confirms its promise in ischaemic heart disease. Eur J Heart Fail. 2014 Dec; 16(12):1268-9. van Oort RJ, Brown JH, Westenbrink BD. PMID: 25452163.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    22. PLCe mediated sustained signaling pathways. Adv Biol Regul. 2015 Jan; 57:17-23. Dusaban SS, Brown JH. PMID: 25453218.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    23. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. PMID: 25236710.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. J Mol Cell Cardiol. 2014 Oct; 75:152-61. Zhao X, Ding EY, Yu OM, Xiang SY, Tan-Sah VP, Yung BS, Hedgpeth J, Neubig RR, Lau LF, Brown JH, Miyamoto S. PMID: 25106095.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2014 Sep; 74:274-83. Di Carlo MN, Said M, Ling H, Valverde CA, De Giusti VC, Sommese L, Palomeque J, Aiello EA, Skapura DG, Rinaldi G, Respress JL, Brown JH, Wehrens XH, Salas MA, Mattiazzi A. PMID: 24949568.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    26. In vivo selective expression of thyroid hormone receptor a1 in endothelial cells attenuates myocardial injury in experimental myocardial infarction in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Aug 01; 307(3):R340-6. Suarez J, Wang H, Scott BT, Ling H, Makino A, Swanson E, Brown JH, Suarez JA, Feinstein S, Diaz-Juarez J, Dillmann WH. PMID: 24848360.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. J Biol Chem. 2014 Jun 20; 289(25):17689-98. Sayyah J, Bartakova A, Nogal N, Quilliam LA, Stupack DG, Brown JH. PMID: 24790104.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    28. CaMKIIdelta subtypes: localization and function. Front Pharmacol. 2014; 5:15. Gray CB, Heller Brown J. PMID: 24575042.
      View in: PubMed   Mentions:
    29. A new non-canonical pathway of Ga(q) protein regulating mitochondrial dynamics and bioenergetics. Cell Signal. 2014 May; 26(5):1135-46. Benincá C, Planagumà J, de Freitas Shuck A, Acín-Perez R, Muñoz JP, de Almeida MM, Brown JH, Murphy AN, Zorzano A, Enríquez JA, Aragay AM. PMID: 24444709.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    30. PLCe, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. Sci Signal. 2013 Dec 17; 6(306):ra108. Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Heller Brown J. PMID: 24345679.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    31. Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. J Physiol. 2014 Mar 01; 592(5):971-90. Zhang DM, Chai Y, Erickson JR, Brown JH, Bers DM, Lin YF. PMID: 24277866.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    32. The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias. Expert Opin Ther Targets. 2013 Aug; 17(8):889-903. Westenbrink BD, Edwards AG, McCulloch AD, Brown JH. PMID: 23789646.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    33. Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3609-14. Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, Brown JH. PMID: 23401561.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    34. Ca2+/Calmodulin-dependent protein kinase II d mediates myocardial ischemia/reperfusion injury through nuclear factor-?B. Circ Res. 2013 Mar 15; 112(6):935-44. Ling H, Gray CB, Zambon AC, Grimm M, Gu Y, Dalton N, Purcell NH, Peterson K, Brown JH. PMID: 23388157.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    35. Epac2 mediates cardiac ß1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22. Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM. PMID: 23363625.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    36. PHLPP1 gene deletion protects the brain from ischemic injury. J Cereb Blood Flow Metab. 2013 Feb; 33(2):196-204. Chen B, Van Winkle JA, Lyden PD, Brown JH, Purcell NH. PMID: 23072745.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    37. Lysophospholipid receptor activation of RhoA and lipid signaling pathways. Biochim Biophys Acta. 2013 Jan; 1831(1):213-22. Xiang SY, Dusaban SS, Brown JH. PMID: 22986288.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    38. Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev. 2012 Oct 01; 26(19):2138-43. Mo JS, Yu FX, Gong R, Brown JH, Guan KL. PMID: 22972936.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    39. APJ acts as a dual receptor in cardiac hypertrophy. Nature. 2012 Aug 16; 488(7411):394-8. Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE, Purcell NH, Catalucci D, Akasaka T, Bueno OF, Vlasuk GP, Kaliman P, Bodmer R, Smith LH, Ashley E, Mercola M, Brown JH, Ruiz-Lozano P. PMID: 22810587.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    40. Identification of potential small molecule binding pockets on Rho family GTPases. PLoS One. 2012; 7(7):e40809. Ortiz-Sanchez JM, Nichols SE, Sayyah J, Brown JH, McCammon JA, Grant BJ. PMID: 22815826.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    41. CaMKIIdC slows [Ca]i decline in cardiac myocytes by promoting Ca sparks. Biophys J. 2012 Jun 06; 102(11):2461-70. Guo T, Zhang T, Ginsburg KS, Mishra S, Brown JH, Bers DM. PMID: 22713561.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    42. Role of phospholipase Ce in physiological phosphoinositide signaling networks. Cell Signal. 2012 Jun; 24(6):1333-43. Smrcka AV, Brown JH, Holz GG. PMID: 22286105.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    43. Novel allosteric sites on Ras for lead generation. PLoS One. 2011; 6(10):e25711. Grant BJ, Lukman S, Hocker HJ, Sayyah J, Brown JH, McCammon JA, Gorfe AA. PMID: 22046245.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    44. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res. 2011 Dec 09; 109(12):1354-62. Mishra S, Gray CB, Miyamoto S, Bers DM, Brown JH. PMID: 21998325.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    45. RhoA protects the mouse heart against ischemia/reperfusion injury. J Clin Invest. 2011 Aug; 121(8):3269-76. Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, Brown JH. PMID: 21747165.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    46. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res. 2011 Jul 08; 109(2):141-50. Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J. PMID: 21597010.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    47. Crossing signals: relationships between ß-adrenergic stimulation and CaMKII activation. Heart Rhythm. 2011 Aug; 8(8):1296-8. Grimm M, Ling H, Brown JH. PMID: 21354330.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    48. CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol. 2011 Oct; 51(4):468-73. Anderson ME, Brown JH, Bers DM. PMID: 21276796.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    49. Overexpression of CaMKIIdc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality. J Am Coll Cardiol. 2011 Jan 25; 57(4):469-79. Dybkova N, Sedej S, Napolitano C, Neef S, Rokita AG, Hünlich M, Brown JH, Kockskämper J, Priori SG, Pieske B, Maier LS. PMID: 21251589.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    50. Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Eur Heart J. 2011 Sep; 32(17):2179-88. Cheng Z, Völkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA. PMID: 21228009.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    51. Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling. J Cardiovasc Pharmacol. 2010 Dec; 56(6):598-603. Mishra S, Ling H, Grimm M, Zhang T, Bers DM, Brown JH. PMID: 20531218.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    52. SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIdC. J Mol Cell Cardiol. 2011 Jan; 50(1):230-8. Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers DM. PMID: 20971119.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    53. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. J Clin Invest. 2010 Oct; 120(10):3680-7. Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown JH, Murphy E, Molkentin JD. PMID: 20890047.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    54. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 2010 Aug; 120(8):2805-16. Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G. PMID: 20644257.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    55. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res. 2010 Aug 20; 107(4):476-84. Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PMID: 20576936.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    56. Revisited and revised: is RhoA always a villain in cardiac pathophysiology? J Cardiovasc Transl Res. 2010 Aug; 3(4):330-43. Miyamoto S, Del Re DP, Xiang SY, Zhao X, Florholmen G, Brown JH. PMID: 20559774.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    57. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res. 2010 Apr 16; 106(7):1265-74. Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA. PMID: 20203306.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    58. Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. Mol Pharmacol. 2010 Mar; 77(3):435-42. Carretero-Ortega J, Walsh CT, Hernández-García R, Reyes-Cruz G, Brown JH, Vázquez-Prado J. PMID: 20018810.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    59. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res. 2010 Feb 05; 106(2):354-62. Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown JH. PMID: 19959778.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    60. beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes. J Mol Cell Cardiol. 2010 Feb; 48(2):342-51. Mani SK, Egan EA, Addy BK, Grimm M, Kasiganesan H, Thiyagarajan T, Renaud L, Brown JH, Kern CB, Menick DR. PMID: 19945464.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    61. Beta-adrenergic receptor signaling in the heart: role of CaMKII. J Mol Cell Cardiol. 2010 Feb; 48(2):322-30. Grimm M, Brown JH. PMID: 19883653.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    62. Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17. J Biol Chem. 2009 Oct 09; 284(41):28180-7. Catalucci D, Latronico MV, Ceci M, Rusconi F, Young HS, Gallo P, Santonastasi M, Bellacosa A, Brown JH, Condorelli G. PMID: 19696029.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    63. Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure. Circ Heart Fail. 2009 Nov; 2(6):664-75. Sag CM, Wadsack DP, Khabbazzadeh S, Abesser M, Grefe C, Neumann K, Opiela MK, Backs J, Olson EN, Brown JH, Neef S, Maier SK, Maier LS. PMID: 19919992.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
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