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Vibha Bhatnagar

TitleAssociate Project Scientist
InstitutionUniversity of California San Diego
DepartmentFamily Medicine and Public Health
Address9500 Gilman Drive #0039
La Jolla CA 92093
Phone858-534-2918
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    Collapse Overview
    Vibha Bhatnagar, MD, MPH is a family medicine physician and clinical epidemiologist with diverse clinical and research experience. Her research focuses on analyzing cohort studies and developing analytic databases from electronic medical records. This work includes analysis of genetic determinants of complex diseases such as hypertension and chronic kidney disease.


    Collapse Research 
    Collapse Research Activities and Funding
    Pharmacogenomics and Hypertension
    NIH/NCRR K23RR020822Jul 15, 2006 - Jun 30, 2011
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nigam SK, Bhatnagar V. The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr Opin Nephrol Hypertens. 2018 Jul; 27(4):305-313. PMID: 29847376.
      View in: PubMed
    2. Melcer T, Walker J, Bhatnagar V, Richard E, Sechriest Ii VF, Galarneau M. Correction: A Comparison of Four-Year Health Outcomes following Combat Amputation and Limb Salvage. PLoS One. 2017; 12(2):e0173214. PMID: 28241079.
      View in: PubMed
    3. Melcer T, Walker J, Bhatnagar V, Richard E, Sechriest VF, Galarneau M. A Comparison of Four-Year Health Outcomes following Combat Amputation and Limb Salvage. PLoS One. 2017; 12(1):e0170569. PMID: 28122002.
      View in: PubMed
    4. Liu HC, Jamshidi N, Chen Y, Eraly SA, Cho SY, Bhatnagar V, Wu W, Bush KT, Abagyan R, Palsson BO, Nigam SK. An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network. J Biol Chem. 2016 09 09; 291(37):19474-86. PMID: 27440044; PMCID: PMC5016685 [Available on 09/09/17].
    5. Bhatnagar V, Richard EL, Wu W, Nievergelt CM, Lipkowitz MS, Jeff J, Maihofer AX, Nigam SK. Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling. Clin Kidney J. 2016 Jun; 9(3):444-53. PMID: 27274832; PMCID: PMC4886906.
    6. Nigam SK, Wu W, Bush KT, Hoenig MP, Blantz RC, Bhatnagar V. Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters. Clin J Am Soc Nephrol. 2015 Nov 06; 10(11):2039-49. PMID: 26490509; PMCID: PMC4633783.
    7. Anthony EG, Richard E, Lipkowitz MS, Bhatnagar V. Association of the ADRB2 (rs2053044) polymorphism and angiotensin-converting enzyme-inhibitor blood pressure response in the African American Study of Kidney Disease and Hypertension. Pharmacogenet Genomics. 2015 Sep; 25(9):444-9. PMID: 26111150.
      View in: PubMed
    8. Bhatnagar V, Richard E, Melcer T, Walker J, Galarneau M. Lower-limb amputation and effect of posttraumatic stress disorder on Department of Veterans Affairs outpatient cost trends. J Rehabil Res Dev. 2015; 52(7):827-38. PMID: 26745304.
      View in: PubMed
    9. Nigam SK, Bush KT, Martovetsky G, Ahn SY, Liu HC, Richard E, Bhatnagar V, Wu W. The organic anion transporter (OAT) family: a systems biology perspective. Physiol Rev. 2015 Jan; 95(1):83-123. PMID: 25540139; PMCID: PMC4281586.
    10. Melcer T, Walker J, Bhatnagar V, Richard E, Han P, Sechriest V, Lebedda M, Quinn K, Galarneau M. Glasgow Coma Scale scores, early opioids, and 4-year psychological outcomes among combat amputees. J Rehabil Res Dev. 2014; 51(5):697-710. PMID: 25509056.
      View in: PubMed
    11. Anthony EG, Richard E, Lipkowitz MS, Kelley ST, Alcaraz JE, Shaffer RA, Bhatnagar V. Association of phosphodiesterase 4 polymorphism (rs702553) with blood pressure in the African American Study of Kidney Disease and Hypertension Genomics Study. Pharmacogenet Genomics. 2013 Aug; 23(8):442-4. PMID: 23778321.
      View in: PubMed
    12. Bhatnagar V, Liu L, Nievergelt CM, Richard E, Brophy VH, Pandey B, Lipkowitz MS, O'Connor DT. Paraoxonase 1 (PON1) C/T-108 association with longitudinal mean arterial blood pressure. Am J Hypertens. 2012 Nov; 25(11):1188-94. PMID: 22854640; PMCID: PMC3515680.
    13. Tsigelny IF, Kovalskyy D, Kouznetsova VL, Balinskyi O, Sharikov Y, Bhatnagar V, Nigam SK. Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport. Cell Biochem Biophys. 2011 Nov; 61(2):251-9. PMID: 21499753.
      View in: PubMed
    14. Fung MM, Salem RM, Lipkowitz MS, Bhatnagar V, Pandey B, Schork NJ, O'Connor DT. Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC). Nephrol Dial Transplant. 2012 Jan; 27(1):197-205. PMID: 21613384; PMCID: PMC3350339.
    15. Lee J, Aziz H, Liu L, Lipkowitz M, O'Connor DT, Richard E, Brophy V, Wassel CL, Blantz R. ß(1)-adrenergic receptor polymorphisms and response to ß-blockade in the African-American study of kidney disease and hypertension (AASK). Am J Hypertens. 2011 Jun; 24(6):694-700. PMID: 21415838.
      View in: PubMed
    16. Hayes JH, Ollendorf DA, Pearson SD, Barry MJ, Kantoff PW, Stewart ST, Bhatnagar V, Sweeney CJ, Stahl JE, McMahon PM. Active surveillance compared with initial treatment for men with low-risk prostate cancer: a decision analysis. JAMA. 2010 Dec 01; 304(21):2373-80. PMID: 21119084; PMCID: PMC3055173.
    17. Salem RM, Pandey B, Richard E, Fung MM, Garcia EP, Brophy VH, Schork NJ, O'Connor DT, Bhatnagar V. The VA Hypertension Primary Care Longitudinal Cohort: Electronic medical records in the post-genomic era. Health Informatics J. 2010 Dec; 16(4):274-86. PMID: 21216807; PMCID: PMC3099595.
    18. Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton BA, O'Connor DT. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cell Mol Neurobiol. 2010 Nov; 30(8):1395-400. PMID: 21061160; PMCID: PMC3008929.
    19. Chen Y, Salem RM, Rao F, Fung MM, Bhatnagar V, Pandey B, Mahata M, Waalen J, Nievergelt CM, Lipkowitz MS, Hamilton BA, Mahata SK, O'Connor DT. Common charge-shift mutation Glu65Lys in K+ channel ß1-Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease. Am J Nephrol. 2010; 32(5):414-24. PMID: 20861615; PMCID: PMC2975731.
    20. Chen Y, Lipkowitz MS, Salem RM, Fung MM, Bhatnagar V, Mahata M, Nievergelt CM, Rao F, Mahata SK, Schork NJ, Hicks PJ, Bowden DW, Freedman BI, Brophy VH, O'Connor DT. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. Am J Nephrol. 2010; 32(1):23-30. PMID: 20484896; PMCID: PMC2914391.
    21. Bhatnagar V, Garcia EP, O'Connor DT, Brophy VH, Alcaraz J, Richard E, Bakris GL, Middleton JP, Norris KC, Wright J, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS. CYP3A4 and CYP3A5 polymorphisms and blood pressure response to amlodipine among African-American men and women with early hypertensive renal disease. Am J Nephrol. 2010; 31(2):95-103. PMID: 19907160; PMCID: PMC2853591.
    22. Fung MM, Chen Y, Lipkowitz MS, Salem RM, Bhatnagar V, Mahata M, Nievergelt CM, Rao F, Mahata SK, Schork NJ, Brophy VH, O'Connor DT. Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. Nephrol Dial Transplant. 2009 Dec; 24(12):3677-86. PMID: 19745105; PMCID: PMC2790952.
    23. Bhatnagar V, O'Connor DT, Brophy VH, Schork NJ, Richard E, Salem RM, Nievergelt CM, Bakris GL, Middleton JP, Norris KC, Wright J, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS. G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions. Am J Hypertens. 2009 Mar; 22(3):332-8. PMID: 19119263; PMCID: PMC2715837.
    24. Ahn SY, Bhatnagar V. Update on the molecular physiology of organic anion transporters. Curr Opin Nephrol Hypertens. 2008 Sep; 17(5):499-505. PMID: 18695391.
      View in: PubMed
    25. Bhatnagar V, Frosch DL, Tally SR, Hamori CJ, Lenert L, Kaplan RM. Evaluation of an internet-based disease trajectory decision tool for prostate cancer screening. Value Health. 2009 Jan-Feb; 12(1):101-8. PMID: 18637139.
      View in: PubMed
    26. Frosch DL, Bhatnagar V, Tally S, Hamori CJ, Kaplan RM. Internet patient decision support: a randomized controlled trial comparing alternative approaches for men considering prostate cancer screening. Arch Intern Med. 2008 Feb 25; 168(4):363-9. PMID: 18299490.
      View in: PubMed
    27. Bhatnagar V, O'Connor DT, Schork NJ, Salem RM, Nievergelt CM, Rana BK, Smith DW, Bakris GL, Middleton JP, Norris KC, Wright JT, Cheek D, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS. Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial. J Hypertens. 2007 Oct; 25(10):2082-92. PMID: 17885551; PMCID: PMC2792638.
    28. Nigam SK, Bush KT, Bhatnagar V. Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol. 2007 Aug; 3(8):443-8. PMID: 17653123.
      View in: PubMed
    29. Bhatnagar V, Stoto MA, Morton SC, Boer R, Bozzette SA. Transmission patterns of smallpox: systematic review of natural outbreaks in Europe and North America since World War II. BMC Public Health. 2006 May 05; 6:126. PMID: 16677388; PMCID: PMC1525174.
    30. Bhatnagar V, Xu G, Hamilton BA, Truong DM, Eraly SA, Wu W, Nigam SK. Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). J Hum Genet. 2006; 51(6):575-80. PMID: 16648942.
      View in: PubMed
    31. Xu G, Bhatnagar V, Wen G, Hamilton BA, Eraly SA, Nigam SK. Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int. 2005 Oct; 68(4):1491-9. PMID: 16164626.
      View in: PubMed
    32. Bhatnagar V, Kaplan RM. Treatment options for prostate cancer: evaluating the evidence. Am Fam Physician. 2005 May 15; 71(10):1915-22. PMID: 15926407.
      View in: PubMed
    33. Stewart ST, Lenert L, Bhatnagar V, Kaplan RM. Utilities for prostate cancer health states in men aged 60 and older. Med Care. 2005 Apr; 43(4):347-55. PMID: 15778638.
      View in: PubMed
    34. Eraly SA, Bush KT, Sampogna RV, Bhatnagar V, Nigam SK. The molecular pharmacology of organic anion transporters: from DNA to FDA? Mol Pharmacol. 2004 Mar; 65(3):479-87. PMID: 14978224.
      View in: PubMed
    35. Bhatnagar V, Stewart ST, Bonney WW, Kaplan RM. Treatment options for localized prostate cancer: quality-adjusted life years and the effects of lead-time. Urology. 2004 Jan; 63(1):103-9. PMID: 14751359.
      View in: PubMed
    36. Eraly SA, Blantz RC, Bhatnagar V, Nigam SK. Novel aspects of renal organic anion transporters. Curr Opin Nephrol Hypertens. 2003 Sep; 12(5):551-8. PMID: 12920404.
      View in: PubMed
    37. Bozzette SA, Boer R, Bhatnagar V, Brower JL, Keeler EB, Morton SC, Stoto MA. A model for a smallpox-vaccination policy. N Engl J Med. 2003 Jan 30; 348(5):416-25. PMID: 12496353.
      View in: PubMed
    38. Pohl M, Bhatnagar V, Mendoza SA, Nigam SK. Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. Kidney Int. 2002 Jan; 61(1):10-9. PMID: 11786080.
      View in: PubMed
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