Vibha Bhatnagar

Title(s)STDT HEALTH PHYSCN 4, Student Health Services
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Address9500 Gilman Drive #
La Jolla CA 92093
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    Vibha Bhatnagar, MD, MPH is a family medicine physician and clinical epidemiologist with diverse clinical and research experience. Her research focuses on analyzing cohort studies and developing analytic databases from electronic medical records. This work includes analysis of genetic determinants of complex diseases such as hypertension and chronic kidney disease.

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    Pharmacogenomics and Hypertension
    NIH K23RR020822Jul 15, 2006 - Jun 30, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Blockade of Organic Anion Transport in Humans After Treatment With the Drug Probenecid Leads to Major Metabolic Alterations in Plasma and Urine. Clin Pharmacol Ther. 2022 09; 112(3):653-664. Granados JC, Bhatnagar V, Nigam SK. PMID: 35490380; PMCID: PMC9398954.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    2. Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease. Pharmaceutics. 2021 Oct 18; 13(10). Nigam AK, Ojha AA, Li JG, Shi D, Bhatnagar V, Nigam KB, Abagyan R, Nigam SK. PMID: 34684013; PMCID: PMC8538396.
      View in: PubMed   Mentions: 8  
    3. Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3. J Biol Chem. 2021 Jan-Jun; 296:100575. Granados JC, Richelle A, Gutierrez JM, Zhang P, Zhang X, Bhatnagar V, Lewis NE, Nigam SK. PMID: 33757768; PMCID: PMC8102410.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    4. Outpatient Pharmacy Prescriptions During the First Year Following Serious Combat Injury: A Retrospective Analysis. Mil Med. 2020 08 14; 185(7-8):e1091-e1100. Melcer T, Walker J, Sazon J, Domasing R, Perez K, Bhatnagar V, Galarneau M. PMID: 32175572.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology. Clin Pharmacol Ther. 2020 07; 108(1):40-53. Nigam SK, Bush KT, Bhatnagar V, Poloyac SM, Momper JD. PMID: 32119114; PMCID: PMC7292762.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    6. Association of Race and Major Adverse Cardiac Events (MACE): The Atherosclerosis Risk in Communities (ARIC) Cohort. J Aging Res. 2020; 2020:7417242. Franey EG, Kritz-Silverstein D, Richard EL, Alcaraz JE, Nievergelt CM, Shaffer RA, Bhatnagar V. PMID: 32280543; PMCID: PMC7114773.
      View in: PubMed   Mentions: 6  
    7. Clinic Use at the Departments of Defense and Veterans Affairs Following Combat Related Amputations. Mil Med. 2020 02 12; 185(1-2):e244-e253. Melcer T, Walker J, Bhatnagar V, Richard E. PMID: 31247095.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning. J Biol Chem. 2020 02 14; 295(7):1829-1842. Nigam AK, Li JG, Lall K, Shi D, Bush KT, Bhatnagar V, Abagyan R, Nigam SK. PMID: 31896576; PMCID: PMC7029110.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    9. Retrospective study of cardiovascular disease risk factors among a cohort of combat veterans with lower limb amputation. Vasc Health Risk Manag. 2019; 15:409-418. Bhatnagar V, Richard E, Melcer T, Walker J, Galarneau M. PMID: 31571892; PMCID: PMC6756832.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    10. A Retrospective Comparison of Five-Year Health Outcomes Following Upper Limb Amputation and Serious Upper Limb Injury in the Iraq and Afghanistan Conflicts. PM R. 2019 06; 11(6):577-589. Melcer T, Walker J, Sechriest VF, Bhatnagar V, Richard E, Perez K, Galarneau M. PMID: 30925199.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr Opin Nephrol Hypertens. 2018 07; 27(4):305-313. Nigam SK, Bhatnagar V. PMID: 29847376; PMCID: PMC6275126.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    12. Correction: A Comparison of Four-Year Health Outcomes following Combat Amputation and Limb Salvage. PLoS One. 2017; 12(2):e0173214. Melcer T, Walker J, Bhatnagar V, Richard E, Sechriest Ii VF, Galarneau M. PMID: 28241079; PMCID: PMC5328383.
      View in: PubMed   Mentions:    Fields:    
    13. A Comparison of Four-Year Health Outcomes following Combat Amputation and Limb Salvage. PLoS One. 2017; 12(1):e0170569. Melcer T, Walker J, Bhatnagar V, Richard E, Sechriest VF, Galarneau M. PMID: 28122002; PMCID: PMC5266314.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    14. An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network. J Biol Chem. 2016 09 09; 291(37):19474-86. Liu HC, Jamshidi N, Chen Y, Eraly SA, Cho SY, Bhatnagar V, Wu W, Bush KT, Abagyan R, Palsson BO, Nigam SK. PMID: 27440044; PMCID: PMC5016685.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    15. Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling. Clin Kidney J. 2016 Jun; 9(3):444-53. Bhatnagar V, Richard EL, Wu W, Nievergelt CM, Lipkowitz MS, Jeff J, Maihofer AX, Nigam SK. PMID: 27274832; PMCID: PMC4886906.
      View in: PubMed   Mentions: 55  
    16. Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters. Clin J Am Soc Nephrol. 2015 Nov 06; 10(11):2039-49. Nigam SK, Wu W, Bush KT, Hoenig MP, Blantz RC, Bhatnagar V. PMID: 26490509; PMCID: PMC4633783.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    17. Association of the ADRB2 (rs2053044) polymorphism and angiotensin-converting enzyme-inhibitor blood pressure response in the African American Study of Kidney Disease and Hypertension. Pharmacogenet Genomics. 2015 Sep; 25(9):444-9. Anthony EG, Richard E, Lipkowitz MS, Bhatnagar V. PMID: 26111150.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    18. Lower-limb amputation and effect of posttraumatic stress disorder on Department of Veterans Affairs outpatient cost trends. J Rehabil Res Dev. 2015; 52(7):827-38. Bhatnagar V, Richard E, Melcer T, Walker J, Galarneau M. PMID: 26745304.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. The organic anion transporter (OAT) family: a systems biology perspective. Physiol Rev. 2015 Jan; 95(1):83-123. Nigam SK, Bush KT, Martovetsky G, Ahn SY, Liu HC, Richard E, Bhatnagar V, Wu W. PMID: 25540139; PMCID: PMC4281586.
      View in: PubMed   Mentions: 178     Fields:    Translation:Humans
    20. Glasgow Coma Scale scores, early opioids, and 4-year psychological outcomes among combat amputees. J Rehabil Res Dev. 2014; 51(5):697-710. Melcer T, Walker J, Bhatnagar V, Richard E, Han P, Sechriest V, Lebedda M, Quinn K, Galarneau M. PMID: 25509056.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Association of phosphodiesterase 4 polymorphism (rs702553) with blood pressure in the African American Study of Kidney Disease and Hypertension Genomics Study. Pharmacogenet Genomics. 2013 Aug; 23(8):442-4. Anthony EG, Richard E, Lipkowitz MS, Kelley ST, Alcaraz JE, Shaffer RA, Bhatnagar V. PMID: 23778321.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Paraoxonase 1 (PON1) C/T-108 association with longitudinal mean arterial blood pressure. Am J Hypertens. 2012 Nov; 25(11):1188-94. Bhatnagar V, Liu L, Nievergelt CM, Richard E, Brophy VH, Pandey B, Lipkowitz MS, O'Connor DT. PMID: 22854640; PMCID: PMC3515680.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport. Cell Biochem Biophys. 2011 Nov; 61(2):251-9. Tsigelny IF, Kovalskyy D, Kouznetsova VL, Balinskyi O, Sharikov Y, Bhatnagar V, Nigam SK. PMID: 21499753.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    24. Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC). Nephrol Dial Transplant. 2012 Jan; 27(1):197-205. Fung MM, Salem RM, Lipkowitz MS, Bhatnagar V, Pandey B, Schork NJ, O'Connor DT, AASK Study Investigators. PMID: 21613384; PMCID: PMC3350339.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    25. β(1)-adrenergic receptor polymorphisms and response to β-blockade in the African-American study of kidney disease and hypertension (AASK). Am J Hypertens. 2011 Jun; 24(6):694-700. Lee J, Aziz H, Liu L, Lipkowitz M, O'Connor DT, Richard E, Brophy V, Wassel CL, Blantz R, AASK Study Investigators, Bhatnagar V. PMID: 21415838.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. The VA Hypertension Primary Care Longitudinal Cohort: Electronic medical records in the post-genomic era. Health Informatics J. 2010 Dec; 16(4):274-86. Salem RM, Pandey B, Richard E, Fung MM, Garcia EP, Brophy VH, Schork NJ, O'Connor DT, Bhatnagar V. PMID: 21216807; PMCID: PMC3099595.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    27. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cell Mol Neurobiol. 2010 Nov; 30(8):1395-400. Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton BA, O'Connor DT. PMID: 21061160; PMCID: PMC3008929.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. Common charge-shift mutation Glu65Lys in K+ channel β₁-Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease. Am J Nephrol. 2010; 32(5):414-24. Chen Y, Salem RM, Rao F, Fung MM, Bhatnagar V, Pandey B, Mahata M, Waalen J, Nievergelt CM, Lipkowitz MS, Hamilton BA, Mahata SK, O'Connor DT. PMID: 20861615; PMCID: PMC2975731.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    29. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. Am J Nephrol. 2010; 32(1):23-30. Chen Y, Lipkowitz MS, Salem RM, Fung MM, Bhatnagar V, Mahata M, Nievergelt CM, Rao F, Mahata SK, Schork NJ, Hicks PJ, Bowden DW, Freedman BI, Brophy VH, O'Connor DT, AASK. PMID: 20484896; PMCID: PMC2914391.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    30. CYP3A4 and CYP3A5 polymorphisms and blood pressure response to amlodipine among African-American men and women with early hypertensive renal disease. Am J Nephrol. 2010; 31(2):95-103. Bhatnagar V, Garcia EP, O'Connor DT, Brophy VH, Alcaraz J, Richard E, Bakris GL, Middleton JP, Norris KC, Wright J, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS, AASK Study Investigators. PMID: 19907160; PMCID: PMC2853591.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    31. Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. Nephrol Dial Transplant. 2009 Dec; 24(12):3677-86. Fung MM, Chen Y, Lipkowitz MS, Salem RM, Bhatnagar V, Mahata M, Nievergelt CM, Rao F, Mahata SK, Schork NJ, Brophy VH, O'Connor DT, AASK Co-Investigators. PMID: 19745105; PMCID: PMC2790952.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    32. G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions. Am J Hypertens. 2009 Mar; 22(3):332-8. Bhatnagar V, O'Connor DT, Brophy VH, Schork NJ, Richard E, Salem RM, Nievergelt CM, Bakris GL, Middleton JP, Norris KC, Wright J, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS, AASK Study Investigators. PMID: 19119263; PMCID: PMC2715837.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    33. Update on the molecular physiology of organic anion transporters. Curr Opin Nephrol Hypertens. 2008 Sep; 17(5):499-505. Ahn SY, Bhatnagar V. PMID: 18695391.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    34. Evaluation of an internet-based disease trajectory decision tool for prostate cancer screening. Value Health. 2009 Jan-Feb; 12(1):101-8. Bhatnagar V, Frosch DL, Tally SR, Hamori CJ, Lenert L, Kaplan RM. PMID: 18637139.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    35. Internet patient decision support: a randomized controlled trial comparing alternative approaches for men considering prostate cancer screening. Arch Intern Med. 2008 Feb 25; 168(4):363-9. Frosch DL, Bhatnagar V, Tally S, Hamori CJ, Kaplan RM. PMID: 18299490.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    36. Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial. J Hypertens. 2007 Oct; 25(10):2082-92. Bhatnagar V, O'Connor DT, Schork NJ, Salem RM, Nievergelt CM, Rana BK, Smith DW, Bakris GL, Middleton JP, Norris KC, Wright JT, Cheek D, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS. PMID: 17885551; PMCID: PMC2792638.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    37. Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol. 2007 Aug; 3(8):443-8. Nigam SK, Bush KT, Bhatnagar V. PMID: 17653123.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    38. Transmission patterns of smallpox: systematic review of natural outbreaks in Europe and North America since World War II. BMC Public Health. 2006 May 05; 6:126. Bhatnagar V, Stoto MA, Morton SC, Boer R, Bozzette SA. PMID: 16677388; PMCID: PMC1525174.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    39. Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). J Hum Genet. 2006; 51(6):575-580. Bhatnagar V, Xu G, Hamilton BA, Truong DM, Eraly SA, Wu W, Nigam SK. PMID: 16648942.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    40. Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int. 2005 Oct; 68(4):1491-9. Xu G, Bhatnagar V, Wen G, Hamilton BA, Eraly SA, Nigam SK. PMID: 16164626.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    41. Treatment options for prostate cancer: evaluating the evidence. Am Fam Physician. 2005 May 15; 71(10):1915-22. Bhatnagar V, Kaplan RM. PMID: 15926407.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    42. Utilities for prostate cancer health states in men aged 60 and older. Med Care. 2005 Apr; 43(4):347-55. Stewart ST, Lenert L, Bhatnagar V, Kaplan RM. PMID: 15778638.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    43. The molecular pharmacology of organic anion transporters: from DNA to FDA? Mol Pharmacol. 2004 Mar; 65(3):479-87. Eraly SA, Bush KT, Sampogna RV, Bhatnagar V, Nigam SK. PMID: 14978224.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    44. Treatment options for localized prostate cancer: quality-adjusted life years and the effects of lead-time. Urology. 2004 Jan; 63(1):103-9. Bhatnagar V, Stewart ST, Bonney WW, Kaplan RM. PMID: 14751359.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    45. Novel aspects of renal organic anion transporters. Curr Opin Nephrol Hypertens. 2003 Sep; 12(5):551-8. Eraly SA, Blantz RC, Bhatnagar V, Nigam SK. PMID: 12920404.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    46. A model for a smallpox-vaccination policy. N Engl J Med. 2003 Jan 30; 348(5):416-25. Bozzette SA, Boer R, Bhatnagar V, Brower JL, Keeler EB, Morton SC, Stoto MA. PMID: 12496353.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansPHPublic Health
    47. Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. Kidney Int. 2002 Jan; 61(1):10-9. Pohl M, Bhatnagar V, Mendoza SA, Nigam SK. PMID: 11786080.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
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