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Sanjay Nigam

Title(s)Professor, Pediatrics
SchoolHealth Sciences
Address9500 Gilman Drive #0735
La Jolla CA 92093
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    Collapse Overview 
    Collapse Overview
    A major focus of our lab is the biology and clinical importance of multi-specific "drug" transporters. We are particularly interested in the SLC22 family of transporters. Among these are the organic anion transporters (OATs) and organic cation transporters (OCTs) as well as other interesting SLC22 transporters--including a number discovered in the lab. These transporters are involved in the handling of many small molecule drugs, toxins and metabolites in the kidney and other organs (Nigam SK, Nature Reviews Drug Discovery 14, 29–44, 2015, see link under Dr. Nigam’s publications).

    We employ in vitro, ex vivo, in vivo (knockout) and computational methods. Current studies focus on SLC22 transporter endogenous function, systems pharmacology and developmental biology--with an eye toward understanding drug handling in infants and young children. A particular emphasis is OAT1, a major drug, toxin and metabolite transporter in the kidney and choroid plexus, which was first identified by our group as NKT. Among other functions, OAT1 appears to be a major transporter of uremic toxins that accumulate in chronic kidney disease (CKD).

    We also have a longstanding interest in kidney organogenesis and tissue engineering of the kidney.

    Research Focus Areas:

  • Developmental Biology

  • Glycobiology

  • Membrane Trafficking

  • Signal Transduction


    • Collapse Research 
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    Role of the renal organic anion transporter OAT1 in metabolism and physiology
    NIH/NIGMS R01GM132938Jul 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Role of the Perinatal Gut Microbiome in the Development of Adult Kidney Organic Anion Transport
    NIH/NIEHS R21ES029663Aug 15, 2018 - Jul 31, 2020
    Role: Principal Investigator
    The Role of OAT1 in Uremia
    NIH/NIDDK R01DK109392Jan 15, 2017 - Dec 31, 2020
    Role: Principal Investigator
    Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
    NIH/NICHD U54HD090259Sep 20, 2016 - Jun 30, 2021
    Role: Co-Investigator
    Structure Function Analysis of the Multi-specific Drug Transporter OCT1
    NIH/NIGMS R01GM104098Jun 1, 2013 - Feb 28, 2017
    Role: Principal Investigator
    Substrate Specificity of the Choroid Plexus and Kidney Transporter Oat1
    NIH/NIGMS R01GM098449Mar 5, 2012 - Feb 29, 2016
    Role: Principal Investigator
    Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy
    NIH/NICHD U54HD071600Sep 26, 2011 - Jun 30, 2016
    Role: Co-Investigator
    Factor Mediating Ureteric Migration and Morphogenesis
    NIH/NIDDK R01DK057286Dec 18, 2009 - Nov 30, 2010
    Role: Principal Investigator
    Mechanism of Fetal and Neonatal Handling of HIV Drugs
    NIH/NIDDK R01DK079784Dec 10, 2009 - Nov 9, 2010
    Role: Principal Investigator
    Systems Biology of Anionic Drug and Metabolite Handling
    NIH/NIGMS R01GM088824Aug 1, 2009 - Jun 30, 2013
    Role: Principal Investigator
    Combined Computational and Wet Lab Screening for Drugs Tested via OATs
    NIH/NINDS R01NS062156Apr 1, 2008 - Mar 31, 2012
    Role: Principal Investigator
    SNPs in Handling of Small Pox Antivirals and Other Drugs
    NIH/NIAID R01AI057695Jul 1, 2005 - Sep 30, 2010
    Role: Principal Investigator
    Identification of Genes Regulating Ureter Morphogenesis
    NIH/NIDDK R01DK065831Jan 1, 2004 - Nov 30, 2008
    Role: Principal Investigator
    Development &Maturation of Kidney Xenobiotic Transport
    NIH/NICHD R01HD040011Jul 1, 2001 - Jun 30, 2007
    Role: Principal Investigator
    KIDNEY DEVELOPMENT AND CYSTOGENESIS
    NIH P01DK054711Mar 1, 1999 - Feb 28, 2005
    Role: Co-Investigator
    KIDNEY ISCHEMIA AND TIGHT JUNCTION RECOVERY
    NIH/NIDDK R01DK053507Jan 1, 1998 - Jun 30, 1999
    Role: Principal Investigator
    CONFERENCE--MECHANISMS OF TISSUE INJURY AND REPAIR
    NIH/NIDDK R13DK053410Aug 1, 1997 - Sep 30, 1998
    Role: Principal Investigator
    ISCHEMIA &THE FOLDING OF MEMBRANE &SECRETED PROTEINS
    NIH/NIDDK R01DK051211Sep 15, 1996 - Jun 30, 2000
    Role: Principal Investigator
    DEVELOPMENT OF THE URINARY COLLECTING SYSTEM
    NIH/NIDDK R01DK049517Sep 1, 1994 - Nov 30, 2004
    Role: Principal Investigator
    KIDNEY EPITHELIAL MORPHOGENESIS AND CELLULAR SIGNALLING
    NIH/NIDDK R01DK044503Sep 30, 1992 - Sep 29, 1996
    Role: Principal Investigator
    GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSION
    NIH/NHLBI P01HL035018Jul 1, 1988 - Nov 30, 1996
    Role: Co-Investigator
    CELLULAR TOPOGENESIS OF THE SODIUM GLUCOSE SYMPORTER
    NIH/NIADDK K11AM001467Sep 1, 1985 - Aug 31, 1990
    Role: Principal Investigator
    CHARACTERIZATION OF G PROTEINS IN THE ROUGH ENDOPLASMIC
    NIH/NIDDK K11DK001467Sep 1, 1985 - Aug 31, 1990
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology. Clin Pharmacol Ther. 2020 Jul; 108(1):40-53. Nigam SK, Bush KT, Bhatnagar V, Poloyac SM, Momper JD. PMID: 32119114.
      View in: PubMed   Mentions:    Fields:    
    2. Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease. JCI Insight. 2020 Apr 09; 5(7). Bush KT, Singh P, Nigam SK. PMID: 32271169.
      View in: PubMed   Mentions:    Fields:    
    3. Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress. Int J Mol Sci. 2020 Mar 15; 21(6). Engelhart DC, Azad P, Ali S, Granados JC, Haddad GG, Nigam SK. PMID: 32183456.
      View in: PubMed   Mentions:    Fields:    
    4. Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs. Int J Mol Sci. 2020 Mar 05; 21(5). Engelhart DC, Granados JC, Shi D, Saier Jr MH, Baker ME, Abagyan R, Nigam SK. PMID: 32150922.
      View in: PubMed   Mentions: 1     Fields:    
    5. Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning. J Biol Chem. 2020 Feb 14; 295(7):1829-1842. Nigam AK, Li JG, Lall K, Shi D, Bush KT, Bhatnagar V, Abagyan R, Nigam SK. PMID: 31896576.
      View in: PubMed   Mentions: 1     Fields:    
    6. A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. Sci Rep. 2019 08 15; 9(1):11879. Rosenthal SB, Bush KT, Nigam SK. PMID: 31417100.
      View in: PubMed   Mentions: 1     Fields:    
    7. Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling. Nat Rev Nephrol. 2019 05; 15(5):301-316. Nigam SK, Bush KT. PMID: 30728454.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. Dynamics of Organic Anion Transporter-Mediated Tubular Secretion during Postnatal Human Kidney Development and Maturation. Clin J Am Soc Nephrol. 2019 04 05; 14(4):540-548. Momper JD, Yang J, Gockenbach M, Vaida F, Nigam SK. PMID: 30885911.
      View in: PubMed   Mentions: 1     Fields:    
    9. Temporal transcriptomic analysis of metabolic genes in maternal organs and placenta during murine pregnancy. Biol Reprod. 2018 12 01; 99(6):1255-1265. Paquette A, Baloni P, Holloman AB, Nigam S, Bammler T, Mao Q, Price ND. PMID: 29939228.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Gene-targeted deletion in mice of the Ets-1 transcription factor, a candidate gene in the Jacobsen syndrome kidney "critical region," causes abnormal kidney development. Am J Med Genet A. 2019 01; 179(1):71-77. Ye M, Xu L, Fu M, Chen D, Mattina T, Zufardi O, Rossi E, Bush KT, Nigam SK, Grossfeld P. PMID: 30422383.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr Opin Nephrol Hypertens. 2018 07; 27(4):305-313. Nigam SK, Bhatnagar V. PMID: 29847376.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Developmental regulation of kidney and liver solute carrier and ATP-binding cassette drug transporters and drug metabolizing enzymes: the role of remote organ communication. Expert Opin Drug Metab Toxicol. 2018 Jun; 14(6):561-570. Momper JD, Nigam SK. PMID: 29746174.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    13. Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin. Am J Physiol Renal Physiol. 2018 08 01; 315(2):F386-F394. Fu Y, Breljak D, Onishi A, Batz F, Patel R, Huang W, Song P, Freeman B, Mayoux E, Koepsell H, Anzai N, Nigam SK, Sabolic I, Vallon V. PMID: 29412698.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    14. The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease. Annu Rev Pharmacol Toxicol. 2018 01 06; 58:663-687. Nigam SK. PMID: 29309257.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    15. The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis. J Biol Chem. 2017 09 22; 292(38):15789-15803. Bush KT, Wu W, Lun C, Nigam SK. PMID: 28765282.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    16. Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes. Sci Rep. 2017 07 10; 7(1):4939. Wu W, Bush KT, Nigam SK. PMID: 28694431.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    17. Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach. J Pharmacol Exp Ther. 2016 10; 359(1):215-29. Liu HC, Goldenberg A, Chen Y, Lun C, Wu W, Bush KT, Balac N, Rodriguez P, Abagyan R, Nigam SK. PMID: 27488918.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    18. An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network. J Biol Chem. 2016 09 09; 291(37):19474-86. Liu HC, Jamshidi N, Chen Y, Eraly SA, Cho SY, Bhatnagar V, Wu W, Bush KT, Abagyan R, Palsson BO, Nigam SK. PMID: 27440044.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    19. Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2. PLoS One. 2016; 11(4):e0152969. He X, Garza D, Nigam SK, Chang G. PMID: 27046168.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling. Clin Kidney J. 2016 Jun; 9(3):444-53. Bhatnagar V, Richard EL, Wu W, Nievergelt CM, Lipkowitz MS, Jeff J, Maihofer AX, Nigam SK. PMID: 27274832.
      View in: PubMed   Mentions:
    21. Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers. Drug Metab Dispos. 2016 07; 44(7):1050-60. Martovetsky G, Bush KT, Nigam SK. PMID: 27044799.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. Elife. 2015 Nov 10; 4. Kumar N, Richter J, Cutts J, Bush KT, Trujillo C, Nigam SK, Gaasterland T, Brafman D, Willert K. PMID: 26554899.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. PLoS One. 2015; 10(11):e0140569. Zhu C, Nigam KB, Date RC, Bush KT, Springer SA, Saier MH, Wu W, Nigam SK. PMID: 26536134.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    24. Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters. Clin J Am Soc Nephrol. 2015 Nov 06; 10(11):2039-49. Nigam SK, Wu W, Bush KT, Hoenig MP, Blantz RC, Bhatnagar V. PMID: 26490509.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    25. Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors. Drug Metab Dispos. 2015 Dec; 43(12):1855-63. Wu W, Bush KT, Liu HC, Zhu C, Abagyan R, Nigam SK. PMID: 26358290.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    26. Transcriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathways. Biochem Biophys Rep. 2015 Sep 01; 3:51-61. Eraly SA, Liu HC, Jamshidi N, Nigam SK. PMID: 26251846.
      View in: PubMed   Mentions:
    27. Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group. Clin Pharmacol Ther. 2015 Sep; 98(3):266-87. Brouwer KL, Aleksunes LM, Brandys B, Giacoia GP, Knipp G, Lukacova V, Meibohm B, Nigam SK, Rieder M, de Wildt SN. PMID: 26088472.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    28. The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-?B signaling, and inflammatory gene expression in human aortic valve cells. FASEB J. 2015 May; 29(5):1859-68. Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA, Nigam S, King CC, Nizet V, Nigam V. PMID: 25630970.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. The organic anion transporter (OAT) family: a systems biology perspective. Physiol Rev. 2015 Jan; 95(1):83-123. Nigam SK, Bush KT, Martovetsky G, Ahn SY, Liu HC, Richard E, Bhatnagar V, Wu W. PMID: 25540139.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    30. What do drug transporters really do? Nat Rev Drug Discov. 2015 Jan; 14(1):29-44. Nigam SK. PMID: 25475361.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimals
    31. Cellular and developmental strategies aimed at kidney tissue engineering. Nephron Exp Nephrol. 2014; 126(2):101. Martovetsky G, Nigam SK. PMID: 24854650.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    32. Relevance of ureteric bud development and branching to tissue engineering, regeneration and repair in acute and chronic kidney disease. Curr Opin Organ Transplant. 2014 Apr; 19(2):153-61. Bush KT, Martovetsky G, Nigam SK. PMID: 24503495.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    33. Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis. Pediatr Nephrol. 2014 Apr; 29(4):727-35. Nigam SK, Bush KT. PMID: 24488503.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    34. Concise review: can the intrinsic power of branching morphogenesis be used for engineering epithelial tissues and organs? Stem Cells Transl Med. 2013 Dec; 2(12):993-1000. Nigam SK. PMID: 24191267.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    35. Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol. 2013 Nov; 24(11):1901-12. Sharma K, Karl B, Mathew AV, Gangoiti JA, Wassel CL, Saito R, Pu M, Sharma S, You YH, Wang L, Diamond-Stanic M, Lindenmeyer MT, Forsblom C, Wu W, Ix JH, Ideker T, Kopp JB, Nigam SK, Cohen CD, Groop PH, Barshop BA, Natarajan L, Nyhan WL, Naviaux RK. PMID: 23949796.
      View in: PubMed   Mentions: 111     Fields:    Translation:Humans
    36. Hepatocyte nuclear factors 4a and 1a regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters. Mol Pharmacol. 2013 Dec; 84(6):808-23. Martovetsky G, Tee JB, Nigam SK. PMID: 24038112.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    37. Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Drug Metab Dispos. 2013 Oct; 41(10):1825-34. Wu W, Jamshidi N, Eraly SA, Liu HC, Bush KT, Palsson BO, Nigam SK. PMID: 23920220.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    38. GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling. Biol Open. 2013; 2(9):952-9. Tee JB, Choi Y, Dnyanmote A, Decambre M, Ito C, Bush KT, Nigam SK. PMID: 24143282.
      View in: PubMed   Mentions:
    39. How much do we know about drug handling by SLC and ABC drug transporters in children? Clin Pharmacol Ther. 2013 Jul; 94(1):27-9. Nigam SK, Bhatnagar V. PMID: 23778708.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    40. Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue. Neurosci Lett. 2013 Feb 08; 534:133-8. Nagle MA, Wu W, Eraly SA, Nigam SK. PMID: 23196129.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    41. N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. J Biol Chem. 2012 Dec 07; 287(50):42064-70. Bush KT, Crawford BE, Garner OB, Nigam KB, Esko JD, Nigam SK. PMID: 23060443.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    42. The storytelling brain. Commentary on "On social attribution: implications of recent cognitive neuroscience research for race, law, and politics". Sci Eng Ethics. 2012 Sep; 18(3):567-71. Nigam SK. PMID: 22843032.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. PLoS One. 2012; 7(7):e40796. Gallegos TF, Martovetsky G, Kouznetsova V, Bush KT, Nigam SK. PMID: 22808265.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    44. A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am J Physiol Renal Physiol. 2012 May 15; 302(10):F1293-9. Vallon V, Eraly SA, Rao SR, Gerasimova M, Rose M, Nagle M, Anzai N, Smith T, Sharma K, Nigam SK, Rieg T. PMID: 22338083.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    45. A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development. Dev Biol. 2012 Apr 01; 364(1):11-21. Gallegos TF, Kouznetsova V, Kudlicka K, Sweeney DE, Bush KT, Willert K, Farquhar MG, Nigam SK. PMID: 22290330.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    46. In vitro culture of embryonic kidney rudiments and isolated ureteric buds. Methods Mol Biol. 2012; 886:13-21. Zhang X, Bush KT, Nigam SK. PMID: 22639247.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    47. Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport. Cell Biochem Biophys. 2011 Nov; 61(2):251-9. Tsigelny IF, Kovalskyy D, Kouznetsova VL, Balinskyi O, Sharikov Y, Bhatnagar V, Nigam SK. PMID: 21499753.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    48. Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis. J Biol Chem. 2011 Sep 09; 286(36):31522-31. Ahn SY, Jamshidi N, Mo ML, Wu W, Eraly SA, Dnyanmote A, Bush KT, Gallegos TF, Sweet DH, Palsson BØ, Nigam SK. PMID: 21757732.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    49. Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. J Biol Chem. 2011 Jul 29; 286(30):26391-5. Torres AM, Dnyanmote AV, Bush KT, Wu W, Nigam SK. PMID: 21652719.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    50. Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate. Dev Biol. 2011 Aug 01; 356(1):19-27. Shah MM, Sakurai H, Gallegos TF, Sweeney DE, Bush KT, Esko JD, Nigam SK. PMID: 21600196.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    51. Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol. 2011 Jul 15; 355(2):394-403. Garner OB, Bush KT, Nigam KB, Yamaguchi Y, Xu D, Esko JD, Nigam SK. PMID: 21586278.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    52. Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorg Med Chem. 2011 Jun 01; 19(11):3320-40. Kouznetsova VL, Tsigelny IF, Nagle MA, Nigam SK. PMID: 21571536.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    53. Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res. 2011 Jun 03; 10(6):2842-51. Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny IF, Nigam SK. PMID: 21476605.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    54. Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney. Mol Pharmacol. 2011 Jul; 80(1):147-54. Sweeney DE, Vallon V, Rieg T, Wu W, Gallegos TF, Nigam SK. PMID: 21493727.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    55. Remote communication through solute carriers and ATP binding cassette drug transporter pathways: an update on the remote sensing and signaling hypothesis. Mol Pharmacol. 2011 May; 79(5):795-805. Wu W, Dnyanmote AV, Nigam SK. PMID: 21325265.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    56. Branching morphogenesis: from individual molecules to a systems biology approach: commentary on "Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney" by Perälä et al. Differentiation. 2011 Feb; 81(2):79-80. Sweeney DE, Gallegos TF, Dnyanmote AV, Zhang X, Nigam SK. PMID: 21168258.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    57. Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling. J Biol Chem. 2011 Jan 07; 286(1):243-51. Nagle MA, Truong DM, Dnyanmote AV, Ahn SY, Eraly SA, Wu W, Nigam SK. PMID: 20921221.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    58. Protein kinase A regulates GDNF/RET-dependent but not GDNF/Ret-independent ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2010 Nov 15; 347(2):337-47. Tee JB, Choi Y, Shah MM, Dnyanmote A, Sweeney DE, Gallegos TF, Johkura K, Ito C, Bush KT, Nigam SK. PMID: 20816800.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    59. Constructing kidney-like tissues from cells based on programs for organ development: toward a method of in vitro tissue engineering of the kidney. Tissue Eng Part A. 2010 Aug; 16(8):2441-55. Rosines E, Johkura K, Zhang X, Schmidt HJ, Decambre M, Bush KT, Nigam SK. PMID: 20214453.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    60. Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice. PLoS One. 2010 May 18; 5(5):e10691. Crawford BE, Garner OB, Bishop JR, Zhang DY, Bush KT, Nigam SK, Esko JD. PMID: 20502530.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    61. Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching. Dev Biol. 2010 Mar 15; 339(2):354-65. Shah MM, Sakurai H, Sweeney DE, Gallegos TF, Bush KT, Esko JD, Nigam SK. PMID: 20059993.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    62. Neuropeptide Y functions as a facilitator of GDNF-induced budding of the Wolffian duct. Development. 2009 Dec; 136(24):4213-24. Choi Y, Tee JB, Gallegos TF, Shah MM, Oishi H, Sakurai H, Kitamura S, Wu W, Bush KT, Nigam SK. PMID: 19934016.
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    63. Interaction of organic cations with organic anion transporters. J Biol Chem. 2009 Nov 06; 284(45):31422-30. Ahn SY, Eraly SA, Tsigelny I, Nigam SK. PMID: 19737926.
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    64. The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects. Am J Physiol Renal Physiol. 2009 Nov; 297(5):F1330-41. Shah MM, Tee JB, Meyer T, Meyer-Schwesinger C, Choi Y, Sweeney DE, Gallegos TF, Johkura K, Rosines E, Kouznetsova V, Rose DW, Bush KT, Sakurai H, Nigam SK. PMID: 19726549.
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    65. Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med. 2009 Sep; 15(9):1046-54. Lancaster MA, Louie CM, Silhavy JL, Sintasath L, Decambre M, Nigam SK, Willert K, Gleeson JG. PMID: 19718039.
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    66. Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis. Mol Pharmacol. 2009 Sep; 76(3):481-90. Ahn SY, Nigam SK. PMID: 19515966.
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    67. Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F210-7. Wu W, Kitamura S, Truong DM, Rieg T, Vallon V, Sakurai H, Bush KT, Vera DR, Ross RS, Nigam SK. PMID: 19439520.
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    68. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics. 2009 Jul 09; 38(2):116-24. Wu W, Baker ME, Eraly SA, Bush KT, Nigam SK. PMID: 19417012.
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    69. Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Sci Signal. 2008 Dec 09; 1(49):ra16. Tsigelny IF, Kouznetsova VL, Sweeney DE, Wu W, Bush KT, Nigam SK. PMID: 19066399.
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    70. How does the ureteric bud branch? J Am Soc Nephrol. 2009 Jul; 20(7):1465-9. Nigam SK, Shah MM. PMID: 19056872.
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    71. Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function. J Bioinform Comput Biol. 2008 Oct; 6(5):885-904. Tsigelny IF, Greenberg J, Kouznetsova V, Nigam SK. PMID: 18942157.
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    72. Organogenesis forum lecture: In vitro kidney development, tissue engineering and systems biology. Organogenesis. 2008 Jul; 4(3):137-43. Nigam SK, Wu W, Bush KT. PMID: 19279725.
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    73. Organic anion transporter 3 contributes to the regulation of blood pressure. J Am Soc Nephrol. 2008 Sep; 19(9):1732-40. Vallon V, Eraly SA, Wikoff WR, Rieg T, Kaler G, Truong DM, Ahn SY, Mahapatra NR, Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, Nigam SK. PMID: 18508962.
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    74. Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics. 2008 Apr 22; 33(2):180-92. Eraly SA, Vallon V, Rieg T, Gangoiti JA, Wikoff WR, Siuzdak G, Barshop BA, Nigam SK. PMID: 18270321.
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    75. MAPAS: a tool for predicting membrane-contacting protein surfaces. Nat Methods. 2008 Feb; 5(2):119. Sharikov Y, Walker RC, Greenberg J, Kouznetsova V, Nigam SK, Miller MA, Masliah E, Tsigelny IF. PMID: 18235431.
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    76. Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F867-73. Vallon V, Rieg T, Ahn SY, Wu W, Eraly SA, Nigam SK. PMID: 18216144.
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    77. Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. J Biol Chem. 2008 Mar 28; 283(13):8654-63. Truong DM, Kaler G, Khandelwal A, Swaan PW, Nigam SK. PMID: 18174163.
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    78. Staged in vitro reconstitution and implantation of engineered rat kidney tissue. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20938-43. Rosines E, Sampogna RV, Johkura K, Vaughn DA, Choi Y, Sakurai H, Shah MM, Nigam SK. PMID: 18087037.
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    79. Glial cell-derived neurotrophic factor independent ureteric bud outgrowth from the Wolffian duct. J Am Soc Nephrol. 2007 Dec; 18(12):3147-55. Maeshima A, Sakurai H, Choi Y, Kitamura S, Vaughn DA, Tee JB, Nigam SK. PMID: 18003772.
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    80. The effect of hyaluronic acid size and concentration on branching morphogenesis and tubule differentiation in developing kidney culture systems: potential applications to engineering of renal tissues. Biomaterials. 2007 Nov; 28(32):4806-17. Rosines E, Schmidt HJ, Nigam SK. PMID: 17706761.
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    81. Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol. 2007 Aug; 3(8):443-8. Nigam SK, Bush KT, Bhatnagar V. PMID: 17653123.
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    82. Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17; 282(33):23841-53. Kaler G, Truong DM, Khandelwal A, Nagle M, Eraly SA, Swaan PW, Nigam SK. PMID: 17553798.
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    83. The developmental nephrome: systems biology in the developing kidney. Curr Opin Nephrol Hypertens. 2007 Jan; 16(1):3-9. Monte JC, Sakurai H, Bush KT, Nigam SK. PMID: 17143064.
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    84. Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. Differentiation. 2006 Dec; 74(9-10):638-47. Meyer TN, Schwesinger C, Sampogna RV, Vaughn DA, Stuart RO, Steer DL, Bush KT, Nigam SK. PMID: 17177859.
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    85. Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. Biochem Biophys Res Commun. 2006 Dec 29; 351(4):872-6. Kaler G, Truong DM, Sweeney DE, Logan DW, Nagle M, Wu W, Eraly SA, Nigam SK. PMID: 17094945.
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    86. Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system. Dev Biol. 2006 Oct 15; 298(2):571-84. Bush KT, Vaughn DA, Li X, Rosenfeld MG, Rose DW, Mendoza SA, Nigam SK. PMID: 16934795.
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    87. Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). J Hum Genet. 2006; 51(6):575-580. Bhatnagar V, Xu G, Hamilton BA, Truong DM, Eraly SA, Wu W, Nigam SK. PMID: 16648942.
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    88. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2006 Jul 15; 295(2):473-85. Maeshima A, Vaughn DA, Choi Y, Nigam SK. PMID: 16643884.
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    89. Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models. Kidney Int. 2006 Mar; 69(5):837-45. Sweet DH, Eraly SA, Vaughn DA, Bush KT, Nigam SK. PMID: 16518343.
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    90. Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem. 2006 Feb 24; 281(8):5072-83. Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaler G, Nigam SK. PMID: 16354673.
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    91. Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney. J Am Soc Nephrol. 2006 Jan; 17(1):188-98. Maeshima A, Sakurai H, Nigam SK. PMID: 16338966.
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    92. Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int. 2005 Oct; 68(4):1491-9. Xu G, Bhatnagar V, Wen G, Hamilton BA, Eraly SA, Nigam SK. PMID: 16164626.
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    93. Heregulin induces glial cell line-derived neurotrophic growth factor-independent, non-branching growth and differentiation of ureteric bud epithelia. J Biol Chem. 2005 Dec 23; 280(51):42181-7. Sakurai H, Bush KT, Nigam SK. PMID: 16183643.
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    94. Implications of gene networks for understanding resilience and vulnerability in the kidney branching program. Physiology (Bethesda). 2004 Dec; 19:339-47. Sampogna RV, Nigam SK. PMID: 15546851.
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    95. Unilateral gestational macromastia--a rare disorder. Malays J Pathol. 2004 Dec; 26(2):125-8. Sharma K, Nigam S, Khurana N, Chaturvedi KU. PMID: 16329566.
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    96. Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Dev Biol. 2004 Nov 01; 275(1):44-67. Meyer TN, Schwesinger C, Bush KT, Stuart RO, Rose DW, Shah MM, Vaughn DA, Steer DL, Nigam SK. PMID: 15464572.
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    97. Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun. 2004 Oct 15; 323(2):429-36. Monte JC, Nagle MA, Eraly SA, Nigam SK. PMID: 15369770.
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    98. Tunicamycin preserves intercellular junctions, cytoarchitecture, and cell-substratum interactions in ATP-depleted epithelial cells. Biochem Biophys Res Commun. 2004 Sep 10; 322(1):223-31. George SK, Meyer TN, Abdeen O, Bush KT, Nigam SK. PMID: 15313195.
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    99. Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Dev Biol. 2004 Aug 15; 272(2):310-27. Steer DL, Shah MM, Bush KT, Stuart RO, Sampogna RV, Meyer TN, Schwesinger C, Bai X, Esko JD, Nigam SK. PMID: 15282150.
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    100. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Physiol Genomics. 2004 Jun 17; 18(1):12-24. Eraly SA, Monte JC, Nigam SK. PMID: 15054140.
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    101. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol. 2004 Oct; 287(4):F602-11. Chen D, Roberts R, Pohl M, Nigam S, Kreidberg J, Wang Z, Heino J, Ivaska J, Coffa S, Harris RC, Pozzi A, Zent R. PMID: 15187002.
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    102. Branching morphogenesis and kidney disease. Development. 2004 Apr; 131(7):1449-62. Shah MM, Sampogna RV, Sakurai H, Bush KT, Nigam SK. PMID: 15023929.
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    103. The molecular pharmacology of organic anion transporters: from DNA to FDA? Mol Pharmacol. 2004 Mar; 65(3):479-87. Eraly SA, Bush KT, Sampogna RV, Bhatnagar V, Nigam SK. PMID: 14978224.
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    104. TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Dev Biol. 2004 Feb 15; 266(2):285-98. Bush KT, Sakurai H, Steer DL, Leonard MO, Sampogna RV, Meyer TN, Schwesinger C, Qiao J, Nigam SK. PMID: 14738877.
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    105. Developmental approaches to kidney tissue engineering. Am J Physiol Renal Physiol. 2004 Jan; 286(1):F1-7. Steer DL, Nigam SK. PMID: 14656756.
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    106. Complex dynamics of chaperone-protein interactions under cellular stress. Cell Biochem Biophys. 2004; 40(3):263-76. Tsigelny IF, Nigam SK. PMID: 15211027.
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    107. Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice. Am J Physiol Renal Physiol. 2004 May; 286(5):F972-8. Sykes D, Sweet DH, Lowes S, Nigam SK, Pritchard JB, Miller DS. PMID: 15075193.
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    108. Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in models of kidney development. Kidney Int. 2003 Dec; 64(6):1997-2008. Stuart RO, Bush KT, Nigam SK. PMID: 14633122.
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    109. From the ureteric bud to the penome. Kidney Int. 2003 Dec; 64(6):2320-2. Nigam SK. PMID: 14633158.
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    110. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20; 426(6964):247-54. Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG. PMID: 14628042.
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    111. Novel aspects of renal organic anion transporters. Curr Opin Nephrol Hypertens. 2003 Sep; 12(5):551-8. Eraly SA, Blantz RC, Bhatnagar V, Nigam SK. PMID: 12920404.
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    112. Biochemical processing of E-cadherin under cellular stress. Biochem Biophys Res Commun. 2003 Jul 25; 307(2):215-23. Keller SH, Nigam SK. PMID: 12859942.
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    113. Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis. Biochem Biophys Res Commun. 2003 Jul 04; 306(3):623-8. Li Z, Stuart RO, Eraly SA, Gittes G, Beier DR, Nigam SK. PMID: 12810064.
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    114. Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun. 2003 Jan 10; 300(2):333-42. Eraly SA, Hamilton BA, Nigam SK. PMID: 12504088.
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    115. A strategy for in vitro propagation of rat nephrons. Kidney Int. 2002 Dec; 62(6):1958-65. Steer DL, Bush KT, Meyer TN, Schwesinger C, Nigam SK. PMID: 12427120.
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    116. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. Biochem Biophys Res Commun. 2002 Oct 11; 297(5):1159-66. Eraly SA, Nigam SK. PMID: 12372408.
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    117. Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem. 2002 Jul 26; 277(30):26934-43. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK. PMID: 12011098.
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    118. Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. Kidney Int. 2002 Jan; 61(1):10-9. Pohl M, Bhatnagar V, Mendoza SA, Nigam SK. PMID: 11786080.
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    119. Characterization of Aspergillus fumigatus protein disulfide isomerase family gene. Gene. 2001 Dec 27; 281(1-2):143-50. Nigam S, Sarma PV, Ghosh PC, Sarma PU. PMID: 11750136.
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    120. EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. Am J Physiol Renal Physiol. 2001 Dec; 281(6):F1148-56. Stuart RO, Pavlova A, Beier D, Li Z, Krijanovski Y, Nigam SK. PMID: 11704567.
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    121. Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis. Mech Dev. 2001 Dec; 109(2):123-35. Qiao J, Bush KT, Steer DL, Stuart RO, Sakurai H, Wachsman W, Nigam SK. PMID: 11731227.
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    122. Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12509-14. Karihaloo A, Karumanchi SA, Barasch J, Jha V, Nickel CH, Yang J, Grisaru S, Bush KT, Nigam S, Rosenblum ND, Sukhatme VP, Cantley LG. PMID: 11606725.
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    123. Identification of pleiotrophin as a mesenchymal factor involved in ureteric bud branching morphogenesis. Development. 2001 Sep; 128(17):3283-93. Sakurai H, Bush KT, Nigam SK. PMID: 11546745.
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    124. Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. J Biol Chem. 2001 Nov 16; 276(46):42753-60. Shankaranarayanan P, Chaitidis P, Kühn H, Nigam S. PMID: 11509556.
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    125. The organic anion transporter family: from physiology to ontogeny and the clinic. Am J Physiol Renal Physiol. 2001 Aug; 281(2):F197-205. Sweet DH, Bush KT, Nigam SK. PMID: 11457711.
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    126. Expanding role of G proteins in tight junction regulation: Galpha(s) stimulates TJ assembly. Biochem Biophys Res Commun. 2001 Jul 13; 285(2):250-6. Saha C, Nigam SK, Denker BM. PMID: 11444833.
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    127. Changes in global gene expression patterns during development and maturation of the rat kidney. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5649-54. Stuart RO, Bush KT, Nigam SK. PMID: 11331749.
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    128. Reassembly of the tight junction after oxidative stress depends on tyrosine kinase activity. J Biol Chem. 2001 Jun 22; 276(25):22048-55. Meyer TN, Schwesinger C, Ye J, Denker BM, Nigam SK. PMID: 11294856.
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    129. Nongestational pure ovarian choriocarcinoma with contralateral teratoma. Gynecol Oncol. 2001 Feb; 80(2):262-6. Goswami D, Sharma K, Zutshi V, Tempe A, Nigam S. PMID: 11161870.
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    130. Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3. Mol Cell Biol. 2001 Feb; 21(3):765-70. Yang Z, Xia Ch, Roberts EA, Bush K, Nigam SK, Goldstein LS. PMID: 11154264.
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    131. Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism. Biochem J. 2001 Jan 01; 353(Pt 1):91-100. Sutherland M, Shankaranarayanan P, Schewe T, Nigam S. PMID: 11115402.
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    132. Matrix metalloproteinases and their inhibitors regulate in vitro ureteric bud branching morphogenesis. Am J Physiol Renal Physiol. 2000 Nov; 279(5):F891-900. Pohl M, Sakurai H, Bush KT, Nigam SK. PMID: 11053050.
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    133. Genesis and reversal of the ischemic phenotype in epithelial cells. J Clin Invest. 2000 Sep; 106(5):621-6. Bush KT, Keller SH, Nigam SK. PMID: 10974012.
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    134. A role for Timeless in epithelial morphogenesis during kidney development. Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18):10038-43. Li Z, Stuart RO, Qiao J, Pavlova A, Bush KT, Pohl M, Sakurai H, Nigam SK. PMID: 10963667.
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    135. Role of hyaluronan and CD44 in in vitro branching morphogenesis of ureteric bud cells. Dev Biol. 2000 Aug 15; 224(2):312-25. Pohl M, Sakurai H, Stuart RO, Nigam SK. PMID: 10926769.
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    136. Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia. Am J Physiol Renal Physiol. 2000 May; 278(5):F847-52. Bush KT, Tsukamoto T, Nigam SK. PMID: 10807598.
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    137. Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct. Am J Physiol Renal Physiol. 2000 Apr; 278(4):F635-43. Pavlova A, Sakurai H, Leclercq B, Beier DR, Yu AS, Nigam SK. PMID: 10751225.
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    138. Acute renal failure. II. Experimental models of acute renal failure: imperfect but indispensable. Am J Physiol Renal Physiol. 2000 Jan; 278(1):F1-F12. Lieberthal W, Nigam SK. PMID: 10644651.
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    139. Branching morphogenesis during kidney development. Annu Rev Physiol. 2000; 62:595-620. Pohl M, Stuart RO, Sakurai H, Nigam SK. PMID: 10845104.
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    140. A role for intracellular calcium in tight junction reassembly after ATP depletion-repletion. Am J Physiol. 1999 10; 277(4):F524-32. Ye J, Tsukamoto T, Sun A, Nigam SK. PMID: 10516276.
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    141. Evolution of gene expression patterns in a model of branching morphogenesis. Am J Physiol. 1999 10; 277(4):F650-63. Pavlova A, Stuart RO, Pohl M, Nigam SK. PMID: 10516290.
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    142. Cell-cell dissociation upon epithelial cell scattering requires a step mediated by the proteasome. J Biol Chem. 1999 Aug 27; 274(35):24579-84. Tsukamoto T, Nigam SK. PMID: 10455122.
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    143. Pretreatment with inducers of ER molecular chaperones protects epithelial cells subjected to ATP depletion. Am J Physiol. 1999 08; 277(2):F211-8. Bush KT, George SK, Zhang PL, Nigam SK. PMID: 10444575.
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    144. Branching morphogenesis independent of mesenchymal-epithelial contact in the developing kidney. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7330-5. Qiao J, Sakurai H, Nigam SK. PMID: 10377414.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    145. Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins. Am J Physiol. 1999 05; 276(5):F737-50. Tsukamoto T, Nigam SK. PMID: 10330056.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    146. Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells. Am J Physiol. 1999 04; 276(4):F581-8. O'Rourke DA, Sakurai H, Spokes K, Kjelsberg C, Takahashi M, Nigam S, Cantley L. PMID: 10198418.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    147. Less degradation, more shock, please. Gastroenterology. 1999 Apr; 116(4):994-5. Bush KT, Nigam SK. PMID: 10092324.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    148. Oxylipin formation in fungi: biotransformation of arachidonic acid to 3-hydroxy-5,8-tetradecadienoic acid by Mucor genevensis. Biochem Biophys Res Commun. 1998 Dec 30; 253(3):703-6. Pohl CH, Botha A, Kock JL, Coetzee DJ, Botes PJ, Schewe T, Nigam S. PMID: 9918790.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsPHPublic Health
    149. Folding of secretory and membrane proteins. N Engl J Med. 1998 Dec 03; 339(23):1688-95. Kuznetsov G, Nigam SK. PMID: 9834307.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    150. Acute renal failure. I. Relative importance of proximal vs. distal tubular injury. Am J Physiol. 1998 11; 275(5):F623-31. Lieberthal W, Nigam SK. PMID: 9815122.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    151. The actin cytoskeleton and integrin expression in the recovery of cell adhesion after oxidant stress to a proximal tubule cell line (JTC-12). J Am Soc Nephrol. 1998 Oct; 9(10):1787-97. Nigam S, Weston CE, Liu CH, Simon EE. PMID: 9773779.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    152. Involvement of Galphai2 in the maintenance and biogenesis of epithelial cell tight junctions. J Biol Chem. 1998 Aug 21; 273(34):21629-33. Saha C, Nigam SK, Denker BM. PMID: 9705295.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    153. In vitro branching tubulogenesis: implications for developmental and cystic disorders, nephron number, renal repair, and nephron engineering. Kidney Int. 1998 Jul; 54(1):14-26. Sakurai H, Nigam SK. PMID: 9648059.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    154. Molecular structure and assembly of the tight junction. Am J Physiol. 1998 01; 274(1):F1-9. Denker BM, Nigam SK. PMID: 9458817.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    155. EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney. Am J Physiol. 1997 Sep; 273(3 Pt 2):F463-72. Sakurai H, Tsukamoto T, Kjelsberg CA, Cantley LG, Nigam SK. PMID: 9321921.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    156. Tight junction proteins form large complexes and associate with the cytoskeleton in an ATP depletion model for reversible junction assembly. J Biol Chem. 1997 Jun 27; 272(26):16133-9. Tsukamoto T, Nigam SK. PMID: 9195909.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    157. An in vitro tubulogenesis system using cell lines derived from the embryonic kidney shows dependence on multiple soluble growth factors. Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12):6279-84. Sakurai H, Barros EJ, Tsukamoto T, Barasch J, Nigam SK. PMID: 9177208.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    158. Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance. J Biol Chem. 1997 Apr 04; 272(14):9086-92. Bush KT, Goldberg AL, Nigam SK. PMID: 9083035.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    159. Distribution and developmentally regulated expression of murine polycystin. Am J Physiol. 1997 Apr; 272(4 Pt 2):F451-9. Geng L, Segal Y, Pavlova A, Barros EJ, Löhning C, Lu W, Nigam SK, Frischauf AM, Reeders ST, Zhou J. PMID: 9140045.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    160. Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem. 1997 Mar 07; 272(10):6471-8. Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier DR, Nigam SK. PMID: 9045672.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    161. Met -/- kidneys express epithelial cells that chemotax and form tubules in response to EGF receptor ligands. Am J Physiol. 1997 Feb; 272(2 Pt 2):F222-8. Kjelsberg C, Sakurai H, Spokes K, Birchmeier C, Drummond I, Nigam S, Cantley LG. PMID: 9124399.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    162. Multiple molecular chaperones complex with misfolded large oligomeric glycoproteins in the endoplasmic reticulum. J Biol Chem. 1997 Jan 31; 272(5):3057-63. Kuznetsov G, Chen LB, Nigam SK. PMID: 9006956.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    163. Transforming growth factor-beta selectively inhibits branching morphogenesis but not tubulogenesis. Am J Physiol. 1997 Jan; 272(1 Pt 2):F139-46. Sakurai H, Nigam SK. PMID: 9039060.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    164. Involvement of a heterotrimeric G protein alpha subunit in tight junction biogenesis. J Biol Chem. 1996 Oct 18; 271(42):25750-3. Denker BM, Saha C, Khawaja S, Nigam SK. PMID: 8824202.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    165. Perturbations in maturation of secretory proteins and their association with endoplasmic reticulum chaperones in a cell culture model for epithelial ischemia. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8584-9. Kuznetsov G, Bush KT, Zhang PL, Nigam SK. PMID: 8710914.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    166. Selective amplification of protein-coding regions of large sets of genes using statistically designed primer sets. Nat Biotechnol. 1996 Jul; 14(7):857-61. López-Nieto CE, Nigam SK. PMID: 9631010.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    167. Dependence of epithelial intercellular junction biogenesis on thapsigargin-sensitive intracellular calcium stores. J Biol Chem. 1996 Jun 07; 271(23):13636-41. Stuart RO, Sun A, Bush KT, Nigam SK. PMID: 8662885.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    168. Molecular characteristics of Na(+)-coupled glucose transporters in adult and embryonic rat kidney. J Biol Chem. 1995 Dec 08; 270(49):29365-71. You G, Lee WS, Barros EJ, Kanai Y, Huo TL, Khawaja S, Wells RG, Nigam SK, Hediger MA. PMID: 7493971.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    169. Epithelial tubulogenesis through branching morphogenesis: relevance to collecting system development. J Am Soc Nephrol. 1995 Oct; 6(4):1151-9. Stuart RO, Barros EJ, Ribeiro E, Nigam SK. PMID: 8589281.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    170. Development of the tubular nephron. Semin Nephrol. 1995 Jul; 15(4):315-26. Stuart RO, Nigam SK. PMID: 7569411.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    171. Regulated assembly of tight junctions by protein kinase C. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6072-6. Stuart RO, Nigam SK. PMID: 7597083.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    172. HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase. Am J Physiol. 1995 Jun; 268(6 Pt 2):F1211-7. Derman MP, Cunha MJ, Barros EJ, Nigam SK, Cantley LG. PMID: 7611461.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    173. Differential tubulogenic and branching morphogenetic activities of growth factors: implications for epithelial tissue development. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4412-6. Barros EJ, Santos OF, Matsumoto K, Nakamura T, Nigam SK. PMID: 7753820.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    174. Determinants of branching tubulogenesis. Curr Opin Nephrol Hypertens. 1995 May; 4(3):209-14. Nigam SK. PMID: 7648213.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    175. Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction. J Cell Biol. 1994 Dec; 127(6 Pt 2):1783-7. Rosen EM, Nigam SK, Goldberg ID. PMID: 7806559.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    176. Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum. Biochem J. 1994 Nov 01; 303 ( Pt 3):705-8. Bush KT, Hendrickson BA, Nigam SK. PMID: 7526846.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    177. Triterpenoid saponins from Madhuca butyracea. Phytochemistry. 1994 Oct; 37(3):827-9. Li XC, Liu YQ, Wang DZ, Yang CR, Nigam SK, Misra G. PMID: 7765693.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    178. Characterization of integrins in cultured human renal cortical tubule epithelial cells. Am J Physiol. 1994 Oct; 267(4 Pt 2):F612-23. Simon EE, Liu CH, Das M, Nigam S, Broekelmann TJ, McDonald JA. PMID: 7943359.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    179. Epithelial inositol 1,4,5-trisphosphate receptors. Multiplicity of localization, solubility, and isoforms. J Biol Chem. 1994 Sep 23; 269(38):23694-9. Bush KT, Stuart RO, Li SH, Moura LA, Sharp AH, Ross CA, Nigam SK. PMID: 8089140.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    180. Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation. J Biol Chem. 1994 Sep 16; 269(37):22990-5. Kuznetsov G, Chen LB, Nigam SK. PMID: 7916014.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    181. Regulation of mitogenesis, motogenesis, and tubulogenesis by hepatocyte growth factor in renal collecting duct cells. Am J Physiol. 1994 Aug; 267(2 Pt 2):F271-80. Cantley LG, Barros EJ, Gandhi M, Rauchman M, Nigam SK. PMID: 8067388.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    182. Involvement of hepatocyte growth factor in kidney development. Dev Biol. 1994 Jun; 163(2):525-9. Santos OF, Barros EJ, Yang XM, Matsumoto K, Nakamura T, Park M, Nigam SK. PMID: 8200486.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    183. Critical role for intracellular calcium in tight junction biogenesis. J Cell Physiol. 1994 Jun; 159(3):423-33. Stuart RO, Sun A, Panichas M, Hebert SC, Brenner BM, Nigam SK. PMID: 8188760.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    184. A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily. J Biol Chem. 1994 Jan 21; 269(3):1744-9. Nigam SK, Goldberg AL, Ho S, Rohde MF, Bush KT. PMID: 8294423.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    185. Characterization and crystallization of recombinant human neurotrophin-4. J Biol Chem. 1994 Jan 07; 269(1):755-9. Fandl JP, Tobkes NJ, McDonald NQ, Hendrickson WA, Ryan TE, Nigam S, Acheson A, Cudny H, Panayotatos N. PMID: 8276879.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    186. HGF-induced tubulogenesis and branching of epithelial cells is modulated by extracellular matrix and TGF-beta. Dev Biol. 1993 Dec; 160(2):293-302. Santos OF, Nigam SK. PMID: 8253265.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    187. Modulation of HGF-induced tubulogenesis and branching by multiple phosphorylation mechanisms. Dev Biol. 1993 Oct; 159(2):535-48. Santos OF, Moura LA, Rosen EM, Nigam SK. PMID: 8405677.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    188. An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. Am J Physiol. 1993 Sep; 265(3 Pt 2):F416-24. Rauchman MI, Nigam SK, Delpire E, Gullans SR. PMID: 8214101.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    189. Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum. Biochem J. 1993 Sep 01; 294 ( Pt 2):511-5. Nigam SK, Jin YJ, Jin MJ, Bush KT, Bierer BE, Burakoff SJ. PMID: 8373365.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    190. Evidence for the presence of specific high affinity cytosolic binding sites for platelet-activating factor in human neutrophils. Biochem Biophys Res Commun. 1993 Jan 15; 190(1):162-6. Svetlov S, Nigam S. PMID: 8380690.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    191. Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):771-6. Müller S, Nigam S. PMID: 1335246.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    192. Toward an understanding of epithelial morphogenesis in health and disease. Curr Opin Nephrol Hypertens. 1992 Dec; 1(2):187-91. Nigam SK, Brenner BM. PMID: 1345616.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    193. Triterpenoidal saponins from Madhuca butyracea. Phytochemistry. 1992 Sep; 31(9):3169-72. Nigam SK, Li XC, Wang DZ, Misra G, Yang CR. PMID: 1368412.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    194. Changes in intracellular calcium during the development of epithelial polarity and junctions. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):6162-6. Nigam SK, Rodriguez-Boulan E, Silver RB. PMID: 1631104.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    195. The role of phosphorylation in development of tight junctions in cultured renal epithelial (MDCK) cells. Biochem Biophys Res Commun. 1991 Dec 16; 181(2):548-53. Nigam SK, Denisenko N, Rodriguez-Boulan E, Citi S. PMID: 1755836.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    196. Lipoxins trigger the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21B:553-6. Fiore S, Nigam S, Serhan CN. PMID: 1825377.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    197. Receptor-mediated action of hepoxilin A3 releases diacylglycerol and arachidonic acid from human neutrophils. Biochem Biophys Res Commun. 1990 Sep 28; 171(3):944-8. Nigam S, Nodes S, Cichon G, Corey EJ, Pace-Asciak CR. PMID: 2171511.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    198. Subcellular distribution of calcium-binding proteins and a calcium-ATPase in canine pancreas. J Cell Biol. 1990 Jul; 111(1):197-200. Nigam SK, Towers T. PMID: 2142161.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    199. Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. J Cell Physiol. 1990 Jun; 143(3):512-23. Nigam S, Fiore S, Luscinskas FW, Serhan CN. PMID: 2162850.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    200. Subcellular distribution of small GTP binding proteins in pancreas: identification of small GTP binding proteins in the rough endoplasmic reticulum. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1296-9. Nigam SK. PMID: 2106133.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    201. Cyclic AMP-dependent protein kinase in canine pancreatic rough endoplasmic reticulum. J Biol Chem. 1989 Oct 05; 264(28):16927-32. Nigam SK, Blobel G. PMID: 2550466.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    202. Identification of a G protein in rough endoplasmic reticulum of canine pancreas. J Biol Chem. 1988 Nov 05; 263(31):16352-7. Audigier Y, Nigam SK, Blobel G. PMID: 3141406.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    203. Ultrastructural changes in liver of mice exposed to hexachlorocyclohexane. Indian J Exp Biol. 1984 Apr; 22(4):199-204. Nigam SK, Lakkad BC, Kranik AB, Thakore KN. PMID: 6207105.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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