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    Sanjay Nigam

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0693
    CA La Jolla 92093
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      Collapse Overview 
      Collapse Overview
      A major focus of our lab is the biology and clinical importance of multi-specific "drug" transporters. We are particularly interested in the SLC22 family of transporters. Among these are the organic anion transporters (OATs) and organic cation transporters (OCTs) as well as other interesting SLC22 transporters--including a number discovered in the lab. These transporters are involved in the handling of many small molecule drugs, toxins and metabolites in the kidney and other organs (Nigam SK, Nature Reviews Drug Discovery 14, 29–44, 2015, see link under Dr. Nigam’s publications).

      We employ in vitro, ex vivo, in vivo (knockout) and computational methods. Current studies focus on SLC22 transporter endogenous function, systems pharmacology and developmental biology--with an eye toward understanding drug handling in infants and young children. A particular emphasis is OAT1, a major drug, toxin and metabolite transporter in the kidney and choroid plexus, which was first identified by our group as NKT. Among other functions, OAT1 appears to be a major transporter of uremic toxins that accumulate in chronic kidney disease (CKD).

      We also have a longstanding interest in kidney organogenesis and tissue engineering of the kidney.

      Research Focus Areas:

    • Developmental Biology

    • Glycobiology

    • Membrane Trafficking

    • Signal Transduction



    • Collapse Research 
      Collapse Research Activities and Funding
      The Role of OAT1 in Uremia
      NIH/NIDDK R01DK109392Jan 15, 2017 - Dec 31, 2020
      Role: Principal Investigator
      Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
      NIH/NICHD U54HD090259Sep 20, 2016 - Jun 30, 2021
      Role: Co-Investigator
      Structure Function Analysis of the Multi-specific Drug Transporter OCT1
      NIH/NIGMS R01GM104098Jun 1, 2013 - Feb 28, 2017
      Role: Principal Investigator
      Substrate Specificity of the Choroid Plexus and Kidney Transporter Oat1
      NIH/NIGMS R01GM098449Mar 5, 2012 - Feb 29, 2016
      Role: Principal Investigator
      Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy
      NIH/NICHD U54HD071600Sep 26, 2011 - Jun 30, 2016
      Role: Co-Investigator
      Systems Biology of Anionic Drug and Metabolite Handling
      NIH/NIGMS R01GM088824Aug 1, 2009 - Jun 30, 2013
      Role: Principal Investigator
      Combined Computational and Wet Lab Screening for Drugs Tested via OATs
      NIH/NINDS R01NS062156Apr 1, 2008 - Mar 31, 2012
      Role: Principal Investigator
      Mechanism of Fetal and Neonatal Handling of HIV Drugs
      NIH/NIDDK R01DK079784Mar 1, 2008 - Aug 31, 2012
      Role: Principal Investigator
      SNPs in Handling of Small Pox Antivirals and Other Drugs
      NIH/NIAID R01AI057695Jul 1, 2005 - Mar 31, 2011
      Role: Principal Investigator
      Identification of Genes Regulating Ureter Morphogenesis
      NIH/NIDDK R01DK065831Jan 1, 2004 - Nov 30, 2008
      Role: Principal Investigator
      Development &Maturation of Kidney Xenobiotic Transport
      NIH/NICHD R01HD040011Jul 1, 2001 - Jun 30, 2007
      Role: Principal Investigator
      Factor Mediating Ureteric Migration and Morphogenesis
      NIH/NIDDK R01DK057286Sep 30, 1999 - Nov 30, 2010
      Role: Principal Investigator
      KIDNEY DEVELOPMENT AND CYSTOGENESIS
      NIH P01DK054711Mar 1, 1999 - Feb 28, 2005
      Role: Co-Investigator
      KIDNEY ISCHEMIA AND TIGHT JUNCTION RECOVERY
      NIH/NIDDK R01DK053507Jan 1, 1998 - Dec 31, 2001
      Role: Principal Investigator
      CONFERENCE--MECHANISMS OF TISSUE INJURY AND REPAIR
      NIH/NIDDK R13DK053410Aug 1, 1997 - Sep 30, 1998
      Role: Principal Investigator
      ISCHEMIA &THE FOLDING OF MEMBRANE &SECRETED PROTEINS
      NIH/NIDDK R01DK051211Sep 15, 1996 - Jun 30, 2000
      Role: Principal Investigator
      DEVELOPMENT OF THE URINARY COLLECTING SYSTEM
      NIH/NIDDK R01DK049517Sep 1, 1994 - Nov 30, 2004
      Role: Principal Investigator
      KIDNEY EPITHELIAL MORPHOGENESIS AND CELLULAR SIGNALLING
      NIH/NIDDK R01DK044503Sep 30, 1992 - Sep 29, 1996
      Role: Principal Investigator
      GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSION
      NIH/NHLBI P01HL035018Mar 1, 1986 - Dec 31, 2009
      Role: Co-Investigator
      CELLULAR TOPOGENESIS OF THE SODIUM GLUCOSE SYMPORTER
      NIH/NIADDK K11AM001467Sep 1, 1985 - Aug 31, 1990
      Role: Principal Investigator
      CHARACTERIZATION OF G PROTEINS IN THE ROUGH ENDOPLASMIC
      NIH/NIDDK K11DK001467Sep 1, 1985 - Aug 31, 1990
      Role: Principal Investigator

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Bush KT, Wu W, Lun C, Nigam S. The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis. J Biol Chem. 2017 Sep 22; 292(38):15789-15803. PMID: 28765282.
        View in: PubMed
      2. Wu W, Bush KT, Nigam S. Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes. Sci Rep. 2017 Jul 10; 7(1):4939. PMID: 28694431.
        View in: PubMed
      3. Liu HC, Goldenberg A, Chen Y, Lun C, Wu W, Bush KT, Balac N, Rodriguez P, Abagyan R, Nigam S. Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach. J Pharmacol Exp Ther. 2016 Oct; 359(1):215-29. PMID: 27488918.
        View in: PubMed
      4. He X, Garza D, Nigam S, Chang G. Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2. PLoS One. 2016; 11(4):e0152969. PMID: 27046168; PMCID: PMC4821612.
      5. Bhatnagar V, Richard EL, Wu W, Nievergelt CM, Lipkowitz MS, Jeff J, Maihofer AX, Nigam S. Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling. Clin Kidney J. 2016 Jun; 9(3):444-53. PMID: 27274832; PMCID: PMC4886906.
      6. Martovetsky G, Bush KT, Nigam S. Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers. Drug Metab Dispos. 2016 Jul; 44(7):1050-60. PMID: 27044799; PMCID: PMC4931883 [Available on 07/01/17].
      7. Kumar N, Richter J, Cutts J, Bush KT, Trujillo C, Nigam S, Gaasterland T, Brafman D, Willert K. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. Elife. 2015 Nov 10; 4. PMID: 26554899; PMCID: PMC4631902.
      8. Zhu C, Nigam KB, Date RC, Bush KT, Springer SA, Saier MH, Wu W, Nigam S. Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. PLoS One. 2015; 10(11):e0140569. PMID: 26536134; PMCID: PMC4633038.
      9. Nigam S, Wu W, Bush KT, Hoenig MP, Blantz RC, Bhatnagar V. Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters. Clin J Am Soc Nephrol. 2015 Nov 06; 10(11):2039-49. PMID: 26490509; PMCID: PMC4633783.
      10. Wu W, Bush KT, Liu HC, Zhu C, Abagyan R, Nigam S. Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors. Drug Metab Dispos. 2015 Dec; 43(12):1855-63. PMID: 26358290; PMCID: PMC4658493 [Available on 12/01/16].
      11. Eraly SA, Liu HC, Jamshidi N, Nigam S. Transcriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathways. Biochem Biophys Rep. 2015 Sep 01; 3:51-61. PMID: 26251846.
        View in: PubMed
      12. Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA, Nigam S, King CC, Nizet V, Nigam V. The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-?B signaling, and inflammatory gene expression in human aortic valve cells. FASEB J. 2015 May; 29(5):1859-68. PMID: 25630970; PMCID: PMC4771066.
      13. Nigam S, Bush KT, Martovetsky G, Ahn SY, Liu HC, Richard E, Bhatnagar V, Wu W. The organic anion transporter (OAT) family: a systems biology perspective. Physiol Rev. 2015 Jan; 95(1):83-123. PMID: 25540139; PMCID: PMC4281586.
      14. Nigam S. What do drug transporters really do? Nat Rev Drug Discov. 2015 Jan; 14(1):29-44. PMID: 25475361; PMCID: PMC4750486.
      15. Martovetsky G, Nigam S. Cellular and developmental strategies aimed at kidney tissue engineering. Nephron Exp Nephrol. 2014; 126(2):101. PMID: 24854650.
        View in: PubMed
      16. Bush KT, Martovetsky G, Nigam S. Relevance of ureteric bud development and branching to tissue engineering, regeneration and repair in acute and chronic kidney disease. Curr Opin Organ Transplant. 2014 Apr; 19(2):153-61. PMID: 24503495.
        View in: PubMed
      17. Nigam S, Bush KT. Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis. Pediatr Nephrol. 2014 Apr; 29(4):727-35. PMID: 24488503.
        View in: PubMed
      18. Nigam S. Concise review: can the intrinsic power of branching morphogenesis be used for engineering epithelial tissues and organs? Stem Cells Transl Med. 2013 Dec; 2(12):993-1000. PMID: 24191267; PMCID: PMC3841094.
      19. Sharma K, Karl B, Mathew AV, Gangoiti JA, Wassel CL, Saito R, Pu M, Sharma S, You YH, Wang L, Diamond-Stanic M, Lindenmeyer MT, Forsblom C, Wu W, Ix JH, Ideker T, Kopp JB, Nigam S, Cohen CD, Groop PH, Barshop BA, Natarajan L, Nyhan WL, Naviaux RK. Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol. 2013 Nov; 24(11):1901-12. PMID: 23949796; PMCID: PMC3810086.
      20. Martovetsky G, Tee JB, Nigam S. Hepatocyte nuclear factors 4a and 1a regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters. Mol Pharmacol. 2013 Dec; 84(6):808-23. PMID: 24038112; PMCID: PMC3834141.
      21. Wu W, Jamshidi N, Eraly SA, Liu HC, Bush KT, Palsson BO, Nigam S. Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Drug Metab Dispos. 2013 Oct; 41(10):1825-34. PMID: 23920220; PMCID: PMC3781372.
      22. Tee JB, Choi Y, Dnyanmote A, Decambre M, Ito C, Bush KT, Nigam S. GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling. Biol Open. 2013; 2(9):952-9. PMID: 24143282; PMCID: PMC3773342.
      23. Nigam S, Bhatnagar V. How much do we know about drug handling by SLC and ABC drug transporters in children? Clin Pharmacol Ther. 2013 Jul; 94(1):27-9. PMID: 23778708.
        View in: PubMed
      24. Nagle MA, Wu W, Eraly SA, Nigam S. Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue. Neurosci Lett. 2013 Feb 08; 534:133-8. PMID: 23196129; PMCID: PMC3591490.
      25. Bush KT, Crawford BE, Garner OB, Nigam KB, Esko JD, Nigam S. N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. J Biol Chem. 2012 Dec 07; 287(50):42064-70. PMID: 23060443; PMCID: PMC3516752.
      26. Nigam S. The storytelling brain. Commentary on "On social attribution: implications of recent cognitive neuroscience research for race, law, and politics". Sci Eng Ethics. 2012 Sep; 18(3):567-71. PMID: 22843032.
        View in: PubMed
      27. Gallegos TF, Martovetsky G, Kouznetsova V, Bush KT, Nigam S. Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. PLoS One. 2012; 7(7):e40796. PMID: 22808265; PMCID: PMC3396597.
      28. Vallon V, Eraly SA, Rao SR, Gerasimova M, Rose M, Nagle M, Anzai N, Smith T, Sharma K, Nigam S, Rieg T. A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am J Physiol Renal Physiol. 2012 May 15; 302(10):F1293-9. PMID: 22338083; PMCID: PMC3362066.
      29. Gallegos TF, Kouznetsova V, Kudlicka K, Sweeney DE, Bush KT, Willert K, Farquhar MG, Nigam S. A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development. Dev Biol. 2012 Apr 01; 364(1):11-21. PMID: 22290330; PMCID: PMC3310225.
      30. Zhang X, Bush KT, Nigam S. In vitro culture of embryonic kidney rudiments and isolated ureteric buds. Methods Mol Biol. 2012; 886:13-21. PMID: 22639247.
        View in: PubMed
      31. Tsigelny IF, Kovalskyy D, Kouznetsova VL, Balinskyi O, Sharikov Y, Bhatnagar V, Nigam S. Conformational changes of the multispecific transporter organic anion transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport. Cell Biochem Biophys. 2011 Nov; 61(2):251-9. PMID: 21499753.
        View in: PubMed
      32. Ahn SY, Jamshidi N, Mo ML, Wu W, Eraly SA, Dnyanmote A, Bush KT, Gallegos TF, Sweet DH, Palsson BØ, Nigam S. Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis. J Biol Chem. 2011 Sep 09; 286(36):31522-31. PMID: 21757732; PMCID: PMC3173137.
      33. Torres AM, Dnyanmote AV, Bush KT, Wu W, Nigam S. Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. J Biol Chem. 2011 Jul 29; 286(30):26391-5. PMID: 21652719; PMCID: PMC3143602.
      34. Shah MM, Sakurai H, Gallegos TF, Sweeney DE, Bush KT, Esko JD, Nigam S. Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate. Dev Biol. 2011 Aug 01; 356(1):19-27. PMID: 21600196; PMCID: PMC3130836.
      35. Garner OB, Bush KT, Nigam KB, Yamaguchi Y, Xu D, Esko JD, Nigam S. Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol. 2011 Jul 15; 355(2):394-403. PMID: 21586278; PMCID: PMC3118867.
      36. Kouznetsova VL, Tsigelny IF, Nagle MA, Nigam S. Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorg Med Chem. 2011 Jun 01; 19(11):3320-40. PMID: 21571536; PMCID: PMC3310230.
      37. Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny IF, Nigam S. Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1). J Proteome Res. 2011 Jun 03; 10(6):2842-51. PMID: 21476605; PMCID: PMC3201759.
      38. Sweeney DE, Vallon V, Rieg T, Wu W, Gallegos TF, Nigam S. Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney. Mol Pharmacol. 2011 Jul; 80(1):147-54. PMID: 21493727; PMCID: PMC3127534.
      39. Wu W, Dnyanmote AV, Nigam S. Remote communication through solute carriers and ATP binding cassette drug transporter pathways: an update on the remote sensing and signaling hypothesis. Mol Pharmacol. 2011 May; 79(5):795-805. PMID: 21325265; PMCID: PMC3082935.
      40. Sweeney DE, Gallegos TF, Dnyanmote AV, Zhang X, Nigam S. Branching morphogenesis: from individual molecules to a systems biology approach: commentary on "Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney" by Perälä et al. Differentiation. 2011 Feb; 81(2):79-80. PMID: 21168258.
        View in: PubMed
      41. Nagle MA, Truong DM, Dnyanmote AV, Ahn SY, Eraly SA, Wu W, Nigam S. Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling. J Biol Chem. 2011 Jan 07; 286(1):243-51. PMID: 20921221; PMCID: PMC3012981.
      42. Tee JB, Choi Y, Shah MM, Dnyanmote A, Sweeney DE, Gallegos TF, Johkura K, Ito C, Bush KT, Nigam S. Protein kinase A regulates GDNF/RET-dependent but not GDNF/Ret-independent ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2010 Nov 15; 347(2):337-47. PMID: 20816800; PMCID: PMC2981800.
      43. Rosines E, Johkura K, Zhang X, Schmidt HJ, Decambre M, Bush KT, Nigam S. Constructing kidney-like tissues from cells based on programs for organ development: toward a method of in vitro tissue engineering of the kidney. Tissue Eng Part A. 2010 Aug; 16(8):2441-55. PMID: 20214453; PMCID: PMC2947461.
      44. Crawford BE, Garner OB, Bishop JR, Zhang DY, Bush KT, Nigam S, Esko JD. Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice. PLoS One. 2010 May 18; 5(5):e10691. PMID: 20502530; PMCID: PMC2872662.
      45. Shah MM, Sakurai H, Sweeney DE, Gallegos TF, Bush KT, Esko JD, Nigam S. Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching. Dev Biol. 2010 Mar 15; 339(2):354-65. PMID: 20059993; PMCID: PMC2834281.
      46. Choi Y, Tee JB, Gallegos TF, Shah MM, Oishi H, Sakurai H, Kitamura S, Wu W, Bush KT, Nigam S. Neuropeptide Y functions as a facilitator of GDNF-induced budding of the Wolffian duct. Development. 2009 Dec; 136(24):4213-24. PMID: 19934016; PMCID: PMC2781055.
      47. Ahn SY, Eraly SA, Tsigelny I, Nigam S. Interaction of organic cations with organic anion transporters. J Biol Chem. 2009 Nov 06; 284(45):31422-30. PMID: 19737926; PMCID: PMC2781538.
      48. Shah MM, Tee JB, Meyer T, Meyer-Schwesinger C, Choi Y, Sweeney DE, Gallegos TF, Johkura K, Rosines E, Kouznetsova V, Rose DW, Bush KT, Sakurai H, Nigam S. The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects. Am J Physiol Renal Physiol. 2009 Nov; 297(5):F1330-41. PMID: 19726549; PMCID: PMC2781331.
      49. Lancaster MA, Louie CM, Silhavy JL, Sintasath L, Decambre M, Nigam S, Willert K, Gleeson JG. Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med. 2009 Sep; 15(9):1046-54. PMID: 19718039; PMCID: PMC2895985.
      50. Ahn SY, Nigam S. Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis. Mol Pharmacol. 2009 Sep; 76(3):481-90. PMID: 19515966; PMCID: PMC2730381.
      51. Wu W, Kitamura S, Truong DM, Rieg T, Vallon V, Sakurai H, Bush KT, Vera DR, Ross RS, Nigam S. Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F210-7. PMID: 19439520; PMCID: PMC2711709.
      52. Wu W, Baker ME, Eraly SA, Bush KT, Nigam S. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics. 2009 Jul 09; 38(2):116-24. PMID: 19417012; PMCID: PMC2712220.
      53. Tsigelny IF, Kouznetsova VL, Sweeney DE, Wu W, Bush KT, Nigam S. Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Sci Signal. 2008 Dec 09; 1(49):ra16. PMID: 19066399; PMCID: PMC3016920.
      54. Nigam S, Shah MM. How does the ureteric bud branch? J Am Soc Nephrol. 2009 Jul; 20(7):1465-9. PMID: 19056872.
        View in: PubMed
      55. Tsigelny IF, Greenberg J, Kouznetsova V, Nigam S. Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function. J Bioinform Comput Biol. 2008 Oct; 6(5):885-904. PMID: 18942157; PMCID: PMC2676871.
      56. Nigam S, Wu W, Bush KT. Organogenesis forum lecture: In vitro kidney development, tissue engineering and systems biology. Organogenesis. 2008 Jul; 4(3):137-43. PMID: 19279725; PMCID: PMC2634587.
      57. Vallon V, Eraly SA, Wikoff WR, Rieg T, Kaler G, Truong DM, Ahn SY, Mahapatra NR, Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, Nigam S. Organic anion transporter 3 contributes to the regulation of blood pressure. J Am Soc Nephrol. 2008 Sep; 19(9):1732-40. PMID: 18508962; PMCID: PMC2518443.
      58. Eraly SA, Vallon V, Rieg T, Gangoiti JA, Wikoff WR, Siuzdak G, Barshop BA, Nigam S. Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics. 2008 Apr 22; 33(2):180-92. PMID: 18270321; PMCID: PMC3016923.
      59. Vallon V, Rieg T, Ahn SY, Wu W, Eraly SA, Nigam S. Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F867-73. PMID: 18216144.
        View in: PubMed
      60. Truong DM, Kaler G, Khandelwal A, Swaan PW, Nigam S. Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. J Biol Chem. 2008 Mar 28; 283(13):8654-63. PMID: 18174163; PMCID: PMC2417182.
      61. Maeshima A, Sakurai H, Choi Y, Kitamura S, Vaughn DA, Tee JB, Nigam S. Glial cell-derived neurotrophic factor independent ureteric bud outgrowth from the Wolffian duct. J Am Soc Nephrol. 2007 Dec; 18(12):3147-55. PMID: 18003772.
        View in: PubMed
      62. Rosines E, Schmidt HJ, Nigam S. The effect of hyaluronic acid size and concentration on branching morphogenesis and tubule differentiation in developing kidney culture systems: potential applications to engineering of renal tissues. Biomaterials. 2007 Nov; 28(32):4806-17. PMID: 17706761; PMCID: PMC2700261.
      63. Nigam S, Bush KT, Bhatnagar V. Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol. 2007 Aug; 3(8):443-8. PMID: 17653123.
        View in: PubMed
      64. Kaler G, Truong DM, Khandelwal A, Nagle M, Eraly SA, Swaan PW, Nigam S. Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17; 282(33):23841-53. PMID: 17553798; PMCID: PMC3812435.
      65. Monte JC, Sakurai H, Bush KT, Nigam S. The developmental nephrome: systems biology in the developing kidney. Curr Opin Nephrol Hypertens. 2007 Jan; 16(1):3-9. PMID: 17143064.
        View in: PubMed
      66. Meyer TN, Schwesinger C, Sampogna RV, Vaughn DA, Stuart RO, Steer DL, Bush KT, Nigam S. Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. Differentiation. 2006 Dec; 74(9-10):638-47. PMID: 17177859.
        View in: PubMed
      67. Kaler G, Truong DM, Sweeney DE, Logan DW, Nagle M, Wu W, Eraly SA, Nigam S. Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. Biochem Biophys Res Commun. 2006 Dec 29; 351(4):872-6. PMID: 17094945; PMCID: PMC1810587.
      68. Bush KT, Vaughn DA, Li X, Rosenfeld MG, Rose DW, Mendoza SA, Nigam S. Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system. Dev Biol. 2006 Oct 15; 298(2):571-84. PMID: 16934795.
        View in: PubMed
      69. Bhatnagar V, Xu G, Hamilton BA, Truong DM, Eraly SA, Wu W, Nigam S. Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). J Hum Genet. 2006; 51(6):575-80. PMID: 16648942.
        View in: PubMed
      70. Maeshima A, Vaughn DA, Choi Y, Nigam S. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2006 Jul 15; 295(2):473-85. PMID: 16643884.
        View in: PubMed
      71. Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaler G, Nigam S. Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem. 2006 Feb 24; 281(8):5072-83. PMID: 16354673.
        View in: PubMed
      72. Maeshima A, Sakurai H, Nigam S. Adult kidney tubular cell population showing phenotypic plasticity, tubulogenic capacity, and integration capability into developing kidney. J Am Soc Nephrol. 2006 Jan; 17(1):188-98. PMID: 16338966.
        View in: PubMed
      73. Xu G, Bhatnagar V, Wen G, Hamilton BA, Eraly SA, Nigam S. Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int. 2005 Oct; 68(4):1491-9. PMID: 16164626.
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      74. Sakurai H, Bush KT, Nigam S. Heregulin induces glial cell line-derived neurotrophic growth factor-independent, non-branching growth and differentiation of ureteric bud epithelia. J Biol Chem. 2005 Dec 23; 280(51):42181-7. PMID: 16183643.
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      75. Sampogna RV, Nigam S. Implications of gene networks for understanding resilience and vulnerability in the kidney branching program. Physiology (Bethesda). 2004 Dec; 19:339-47. PMID: 15546851.
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      76. Meyer TN, Schwesinger C, Bush KT, Stuart RO, Rose DW, Shah MM, Vaughn DA, Steer DL, Nigam S. Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Dev Biol. 2004 Nov 01; 275(1):44-67. PMID: 15464572.
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      77. Monte JC, Nagle MA, Eraly SA, Nigam S. Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun. 2004 Oct 15; 323(2):429-36. PMID: 15369770.
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      78. George SK, Meyer TN, Abdeen O, Bush KT, Nigam S. Tunicamycin preserves intercellular junctions, cytoarchitecture, and cell-substratum interactions in ATP-depleted epithelial cells. Biochem Biophys Res Commun. 2004 Sep 10; 322(1):223-31. PMID: 15313195.
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      79. Steer DL, Shah MM, Bush KT, Stuart RO, Sampogna RV, Meyer TN, Schwesinger C, Bai X, Esko JD, Nigam S. Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Dev Biol. 2004 Aug 15; 272(2):310-27. PMID: 15282150.
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      80. Eraly SA, Monte JC, Nigam S. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Physiol Genomics. 2004 Jun 17; 18(1):12-24. PMID: 15054140.
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      81. Chen D, Roberts R, Pohl M, Nigam S, Kreidberg J, Wang Z, Heino J, Ivaska J, Coffa S, Harris RC, Pozzi A, Zent R. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol. 2004 Oct; 287(4):F602-11. PMID: 15187002.
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      82. Shah MM, Sampogna RV, Sakurai H, Bush KT, Nigam S. Branching morphogenesis and kidney disease. Development. 2004 Apr; 131(7):1449-62. PMID: 15023929.
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      83. Eraly SA, Bush KT, Sampogna RV, Bhatnagar V, Nigam S. The molecular pharmacology of organic anion transporters: from DNA to FDA? Mol Pharmacol. 2004 Mar; 65(3):479-87. PMID: 14978224.
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      84. Bush KT, Sakurai H, Steer DL, Leonard MO, Sampogna RV, Meyer TN, Schwesinger C, Qiao J, Nigam S. TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Dev Biol. 2004 Feb 15; 266(2):285-98. PMID: 14738877.
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      85. Tsigelny IF, Nigam S. Complex dynamics of chaperone-protein interactions under cellular stress. Cell Biochem Biophys. 2004; 40(3):263-76. PMID: 15211027.
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      86. Steer DL, Nigam S. Developmental approaches to kidney tissue engineering. Am J Physiol Renal Physiol. 2004 Jan; 286(1):F1-7. PMID: 14656756.
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      87. Stuart RO, Bush KT, Nigam S. Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in models of kidney development. Kidney Int. 2003 Dec; 64(6):1997-2008. PMID: 14633122.
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      88. Nigam S. From the ureteric bud to the penome. Kidney Int. 2003 Dec; 64(6):2320-2. PMID: 14633158.
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      89. Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam S, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20; 426(6964):247-54. PMID: 14628042.
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      90. Eraly SA, Blantz RC, Bhatnagar V, Nigam S. Novel aspects of renal organic anion transporters. Curr Opin Nephrol Hypertens. 2003 Sep; 12(5):551-8. PMID: 12920404.
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      91. Keller SH, Nigam S. Biochemical processing of E-cadherin under cellular stress. Biochem Biophys Res Commun. 2003 Jul 25; 307(2):215-23. PMID: 12859942.
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      92. Li Z, Stuart RO, Eraly SA, Gittes G, Beier DR, Nigam S. Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis. Biochem Biophys Res Commun. 2003 Jul 04; 306(3):623-8. PMID: 12810064.
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      93. Eraly SA, Hamilton BA, Nigam S. Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun. 2003 Jan 10; 300(2):333-42. PMID: 12504088.
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      94. Steer DL, Bush KT, Meyer TN, Schwesinger C, Nigam S. A strategy for in vitro propagation of rat nephrons. Kidney Int. 2002 Dec; 62(6):1958-65. PMID: 12427120.
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      95. Eraly SA, Nigam S. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. Biochem Biophys Res Commun. 2002 Oct 11; 297(5):1159-66. PMID: 12372408.
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      96. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam S. Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem. 2002 Jul 26; 277(30):26934-43. PMID: 12011098.
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      97. Pohl M, Bhatnagar V, Mendoza SA, Nigam S. Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. Kidney Int. 2002 Jan; 61(1):10-9. PMID: 11786080.
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