Sucheta Vaingankar

Title(s)Associate Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Hypertensive kidney disease: Novel pathogenic and therapeutic pathway
    NIH R01DK094894Jun 15, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Homeostatic regulation of autonomic physiology by chromogranin A
    NIH R01HL108629Dec 1, 2011 - Nov 30, 2016
    Role: Principal Investigator
    Rescue of Chga knockout phenotype by CHGA-BAC transgene
    NIH K01DK069613Mar 15, 2005 - Feb 28, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tubule dysfunction and injury and future risk of sepsis-associated acute kidney injury. Clin Nephrol. 2023 Dec 29. Bullen AL, Katz R, Garimella PS, Vaingankar S, Judd SE, Rifkin DE, Gutierrez OM, Wang H, Ix JH. PMID: 38156782.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Urine Uromodulin, Kidney Tubulointerstitial Fibrosis, and Furosemide Response. Nephron. 2023 Dec 01. Bullen AL, Vaingankar S, Madero M, Lopez Gil S, Macedo E, Ix JH, Rifkin DE, Garimella PS. PMID: 38043509.
      View in: PubMed   Mentions:    Fields:    
    3. Clinical Characteristics and Outcomes of Drug-Induced Acute Kidney Injury Cases. Kidney Int Rep. 2023 Nov; 8(11):2333-2344. Yousif ZK, Koola JD, Macedo E, Cerda J, Goldstein SL, Chakravarthi R, Lewington A, Selewski D, Zappitelli M, Cruz D, Tolwani A, Joy MS, Jha V, Ramachandran R, Ostermann M, Pandya B, Acharya A, Brophy P, Ponce D, Steinke J, Bouchard J, Irarrazabal CE, Irarrazabal R, Boltansky A, Askenazi D, Kolhe N, Claure-Del Granado R, Benador N, Castledine C, Davenport A, Barratt J, Bhandari S, Riley AA, Davis TK, Farmer C, Hogarth M, Thomas M, Murray PT, Robinson-Cohen C, Nicoletti P, Vaingankar S, Mehta R, Awdishu L. PMID: 38025217; PMCID: PMC10658426.
      View in: PubMed   Mentions:
    4. UAB-UCSD O'Brien Center for Acute Kidney Injury Research. Am J Physiol Renal Physiol. 2021 05 01; 320(5):F870-F882. Curtis LM, George J, Vallon V, Barnes S, Darley-Usmar V, Vaingankar S, Cutter GR, Gutierrez OM, Seifert M, Ix JH, Mehta RL, Sanders PW, Agarwal A. PMID: 33779316; PMCID: PMC8424552.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Urinary Exosomes Identify Inflammatory Pathways in Vancomycin Associated Acute Kidney Injury. Int J Mol Sci. 2021 Mar 10; 22(6). Awdishu L, Le A, Amato J, Jani V, Bal S, Mills RH, Carrillo-Terrazas M, Gonzalez DJ, Tolwani A, Acharya A, Cerda J, Joy MS, Nicoletti P, Macedo E, Vaingankar S, Mehta R, RamachandraRao SP. PMID: 33801801; PMCID: PMC7999309.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    6. Furosemide stress test and interstitial fibrosis in kidney biopsies in chronic kidney disease. BMC Nephrol. 2020 03 06; 21(1):87. Rivero J, Rodríguez F, Soto V, Macedo E, Chawla LS, Mehta RL, Vaingankar S, Garimella PS, Garza C, Madero M. PMID: 32143585; PMCID: PMC7060600.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    7. Chromogranin A pathway: from pathogenic molecule to renal disease. J Hypertens. 2020 03; 38(3):456-466. Mir SA, Biswas N, Cheung W, Wan J, Webster N, Macedo E, O'Connor DT, Vaingankar SM. PMID: 31714338; PMCID: PMC9109708.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    8. Author Correction: A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function. Sci Rep. 2020 Feb 14; 10(1):2996. Miramontes-Gonzalez JP, Hightower CM, Zhang K, Kurosaki H, Schork AJ, Biswas N, Vaingankar S, Mahata M, Lipkowitz MS, Nievergelt CM, Baker DG, Ziegler MG, León-Jiménez D, González-Sarmiento R, Ichinose H, O'Connor DT. PMID: 32060363; PMCID: PMC7021692.
      View in: PubMed   Mentions:    Fields:    
    9. A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function. Sci Rep. 2019 03 25; 9(1):5055. Miramontes-Gonzalez JP, Hightower CM, Zhang K, Kurosaki H, Schork AJ, Biswas N, Vaingankar S, Mahata M, Lipkowitz MS, Nievergelt CM, Baker DG, Ziegler MG, León-Jiménez D, González-Sarmiento R, Ichinose H, O'Connor DT. PMID: 30911067; PMCID: PMC6433864.
      View in: PubMed   Mentions: 3     Fields:    
    10. Uric Acid and Acute Kidney Injury in the Critically Ill. Kidney Med. 2019 Jan-Feb; 1(1):21-30. Srivastava A, Palsson R, Leaf DE, Higuera A, Chen ME, Palacios P, Baron RM, Sabbisetti V, Hoofnagle AN, Vaingankar SM, Palevsky PM, Waikar SS. PMID: 32734180; PMCID: PMC7380422.
      View in: PubMed   Mentions: 2  
    11. Mice overexpressing chromogranin A display hypergranulogenic adrenal glands with attenuated ATP levels contributing to the hypertensive phenotype. J Hypertens. 2018 05; 36(5):1115-1128. Mir SA, Li Y, Story JD, Bal S, Awdishu L, Street AA, Mehta RL, Singh P, Vaingankar SM. PMID: 29389743; PMCID: PMC6462411.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Stability of Fibroblast Growth Factor 23 in Human Plasma. J Appl Lab Med. 2017 May 01; 1(6):729-734. Cui S, Vaingankar SM, Stenger A, Waikar SS, Leaf DE. PMID: 33379820.
      View in: PubMed   Mentions: 2     Fields:    
    13. Effects of transgenic expression of dopamine beta hydroxylase (Dbh) gene on blood pressure in spontaneously hypertensive rats. Physiol Res. 2016 12 13; 65(6):1039-1044. Pravenec M, Landa V, Zídek V, Mlejnek P, Šilhavý J, Mir SA, Vaingankar SM, Wang J, Kurtz TW. PMID: 27959576; PMCID: PMC5586076.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    14. Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system. BMC Med Genet. 2016 Mar 11; 17:21. Biswas N, Maihofer AX, Mir SA, Rao F, Zhang K, Khandrika S, Mahata M, Friese RS, Hightower CM, Mahata SK, Baker DG, Nievergelt CM, Vaingankar SM, O'Connor DT. PMID: 26969407; PMCID: PMC4788869.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. Analysis and validation of traits associated with a single nucleotide polymorphism Gly364Ser in catestatin using humanized chromogranin A mouse models. J Hypertens. 2016 Jan; 34(1):68-78. Mir SA, Zhang K, Milic M, Gu Y, Rieg T, Ziegler M, Vaingankar SM. PMID: 26556564; PMCID: PMC5580682.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Molecular Mechanism for Hypertensive Renal Disease: Differential Regulation of Chromogranin A Expression at 3'-Untranslated Region Polymorphism C+87T by MicroRNA-107. J Am Soc Nephrol. 2015 Aug; 26(8):1816-25. Zhang K, Mir SA, Hightower CM, Miramontes-Gonzalez JP, Maihofer AX, Chen Y, Mahata SK, Nievergelt CM, Schork NJ, Freedman BI, Vaingankar SM, O'Connor DT. PMID: 25392232; PMCID: PMC4520173.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    17. Cardiac electrical activity in a genomically "humanized" chromogranin a monogenic mouse model with hyperadrenergic hypertension. J Cardiovasc Transl Res. 2014 Jul; 7(5):483-493. Dev NB, Mir SA, Gayen JR, Siddiqui JA, Mustapic M, Vaingankar SM. PMID: 24821335; PMCID: PMC4101044.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    18. Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms. J Neurochem. 2014 Apr; 129(1):48-59. Zhang K, Biswas N, Gayen JR, Miramontes-Gonzalez JP, Hightower CM, Mustapic M, Mahata M, Huang CT, Hook VY, Mahata SK, Vaingankar S, O'Connor DT. PMID: 24266713; PMCID: PMC3992281.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    19. MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension. Hum Mol Genet. 2013 Sep 15; 22(18):3624-40. Friese RS, Altshuler AE, Zhang K, Miramontes-Gonzalez JP, Hightower CM, Jirout ML, Salem RM, Gayen JR, Mahapatra NR, Biswas N, Cale M, Vaingankar SM, Kim HS, Courel M, Taupenot L, Ziegler MG, Schork NJ, Pravenec M, Mahata SK, Schmid-Schönbein GW, O'Connor DT. PMID: 23674521; PMCID: PMC3749858.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    20. Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension. Curr Hypertens Rep. 2011 Feb; 13(1):36-45. Zhang K, Chen Y, Wen G, Mahata M, Rao F, Fung MM, Vaingankar S, Biswas N, Gayen JR, Friese RS, Mahata SK, Hamilton BA, O'Connor DT. PMID: 21104344; PMCID: PMC3016145.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    21. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cell Mol Neurobiol. 2010 Nov; 30(8):1395-400. Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton BA, O'Connor DT. PMID: 21061160; PMCID: PMC3008929.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    22. Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses. J Hypertens. 2010 Apr; 28(4):817-25. Vaingankar SM, Li Y, Biswas N, Gayen J, Choksi S, Rao F, Ziegler MG, Mahata SK, O'Connor DT. PMID: 20139771; PMCID: PMC2947860.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    23. Long human CHGA flanking chromosome 14 sequence required for optimal BAC transgenic "rescue" of disease phenotypes in the mouse Chga knockout. Physiol Genomics. 2010 Mar 03; 41(1):91-101. Vaingankar SM, Li Y, Corti A, Biswas N, Gayen J, O'Connor DT, Mahata SK. PMID: 20009010; PMCID: PMC2841496.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    24. A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem. 2009 Oct 16; 284(42):28498-509. Gayen JR, Saberi M, Schenk S, Biswas N, Vaingankar SM, Cheung WW, Najjar SM, O'Connor DT, Bandyopadhyay G, Mahata SK. PMID: 19706599; PMCID: PMC2781393.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    25. Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides. Endocrinology. 2009 Aug; 150(8):3547-57. Biswas N, Rodriguez-Flores JL, Courel M, Gayen JR, Vaingankar SM, Mahata M, Torpey JW, Taupenot L, O'Connor DT, Mahata SK. PMID: 19372204; PMCID: PMC2717865.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    26. Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B. Circ Cardiovasc Genet. 2009 Feb; 2(1):46-56. Zhang K, Rao F, Rana BK, Gayen JR, Calegari F, King A, Rosa P, Huttner WB, Stridsberg M, Mahata M, Vaingankar S, Mahboubi V, Salem RM, Rodriguez-Flores JL, Fung MM, Smith DW, Schork NJ, Ziegler MG, Taupenot L, Mahata SK, O'Connor DT. PMID: 20011129; PMCID: PMC2792940.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    27. Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. J Am Coll Cardiol. 2008 Oct 28; 52(18):1468-81. Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT. PMID: 19017515; PMCID: PMC2659417.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    28. Chromogranins A and B and secretogranin II: evolutionary and functional aspects. Acta Physiol (Oxf). 2008 Feb; 192(2):309-24. Montero-Hadjadje M, Vaingankar S, Elias S, Tostivint H, Mahata SK, Anouar Y. PMID: 18005393.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    29. Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin. Endocrinology. 2008 Feb; 149(2):749-57. Biswas N, Vaingankar SM, Mahata M, Das M, Gayen JR, Taupenot L, Torpey JW, O'Connor DT, Mahata SK. PMID: 17991725; PMCID: PMC2219303.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    30. Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk. J Clin Invest. 2007 Sep; 117(9):2658-71. Zhang L, Rao F, Zhang K, Khandrika S, Das M, Vaingankar SM, Bao X, Rana BK, Smith DW, Wessel J, Salem RM, Rodriguez-Flores JL, Mahata SK, Schork NJ, Ziegler MG, O'Connor DT. PMID: 17717598; PMCID: PMC1950457.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    31. Biogenesis of the secretory granule: chromogranin A coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation. Biochemistry. 2007 Sep 25; 46(38):10999-1012. Mosley CA, Taupenot L, Biswas N, Taulane JP, Olson NH, Vaingankar SM, Wen G, Schork NJ, Ziegler MG, Mahata SK, O'Connor DT. PMID: 17718510.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    32. Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension. Circulation. 2007 May 01; 115(17):2271-81. Rao F, Wen G, Gayen JR, Das M, Vaingankar SM, Rana BK, Mahata M, Kennedy BP, Salem RM, Stridsberg M, Abel K, Smith DW, Eskin E, Schork NJ, Hamilton BA, Ziegler MG, Mahata SK, O'Connor DT. PMID: 17438154.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    33. Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin. Diabetes Obes Metab. 2006 Nov; 8(6):621-33. Zhang K, Rao F, Wen G, Salem RM, Vaingankar S, Mahata M, Mahapatra NR, Lillie EO, Cadman PE, Friese RS, Hamilton BA, Hook VY, Mahata SK, Taupenot L, O'Connor DT. PMID: 17026486.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    34. Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest. 2005 Jul; 115(7):1942-52. Mahapatra NR, O'Connor DT, Vaingankar SM, Hikim AP, Mahata M, Ray S, Staite E, Wu H, Gu Y, Dalton N, Kennedy BP, Ziegler MG, Ross J, Mahata SK. PMID: 16007257; PMCID: PMC1159140.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    35. Catestatin--a novel neuropeptide in carcinoid tumors of the appendix. Anticancer Res. 2004 Jan-Feb; 24(1):311-6. Prommegger R, Ensinger C, Adlassnig C, Vaingankar S, Mahata SK, Marksteiner J, Margreiter R. PMID: 15015613.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. Subcellular targeting and function of osteoblast nucleotide pyrophosphatase phosphodiesterase 1. Am J Physiol Cell Physiol. 2004 May; 286(5):C1177-87. Vaingankar SM, Fitzpatrick TA, Johnson K, Goding JW, Maurice M, Terkeltaub R. PMID: 15075217.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    37. Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Nat Genet. 2003 Aug; 34(4):379-81. Rutsch F, Ruf N, Vaingankar S, Toliat MR, Suk A, Höhne W, Schauer G, Lehmann M, Roscioli T, Schnabel D, Epplen JT, Knisely A, Superti-Furga A, McGill J, Filippone M, Sinaiko AR, Vallance H, Hinrichs B, Smith W, Ferre M, Terkeltaub R, Nürnberg P. PMID: 12881724.
      View in: PubMed   Mentions: 258     Fields:    Translation:Humans
    38. PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am J Pathol. 2001 Feb; 158(2):543-54. Rutsch F, Vaingankar S, Johnson K, Goldfine I, Maddux B, Schauerte P, Kalhoff H, Sano K, Boisvert WA, Superti-Furga A, Terkeltaub R. PMID: 11159191; PMCID: PMC1850320.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    39. Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression. Blood. 2000 Dec 01; 96(12):3696-706. Li QJ, Vaingankar S, Sladek FM, Martins-Green M. PMID: 11090049.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    40. Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1. Am J Physiol Regul Integr Comp Physiol. 2000 Oct; 279(4):R1365-77. Johnson KA, Hessle L, Vaingankar S, Wennberg C, Mauro S, Narisawa S, Goding JW, Sano K, Millan JL, Terkeltaub R. PMID: 11004006.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    41. Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Arthritis Rheum. 1999 Sep; 42(9):1986-97. Johnson K, Vaingankar S, Chen Y, Moffa A, Goldring MB, Sano K, Jin-Hua P, Sali A, Goding J, Terkeltaub R. PMID: 10513816.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    42. Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor. J Biol Chem. 1999 May 28; 274(22):15454-65. Li Q, Vaingankar SM, Green HM, Martins-Green M. PMID: 10336436.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. Thrombin aivation of the 9E3/CEF4 chemokine involves tyrosine kinases including c-src and the epidermal growth factor receptor. J Biol Chem. 1998 Feb 27; 273(9):5226-34. Vaingankar SM, Martins-Green M. PMID: 9478978.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
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