Loading...

Sucheta Vaingankar

TitleAssociate Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0838
La Jolla CA 92093
Phone858-246-0815
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Hypertensive kidney disease: Novel pathogenic and therapeutic pathway
    NIH/NIDDK R01DK094894Jun 15, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Homeostatic regulation of autonomic physiology by chromogranin A
    NIH/NHLBI R01HL108629Dec 1, 2011 - Nov 30, 2015
    Role: Principal Investigator
    Rescue of Chga knockout phenotype by CHGA-BAC transgene
    NIH/NIDDK K01DK069613Mar 15, 2005 - Feb 28, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Mir SA, Li Y, Story JD, Bal S, Awdishu L, Street AA, Mehta RL, Singh P, Vaingankar S. Mice overexpressing chromogranin A display hypergranulogenic adrenal glands with attenuated ATP levels contributing to the hypertensive phenotype. J Hypertens. 2018 May; 36(5):1115-1128. PMID: 29389743.
      View in: PubMed
    2. Pravenec M, Landa V, Zídek V, Mlejnek P, Šilhavý J, Mir SA, Vaingankar S, Wang J, Kurtz TW. Effects of transgenic expression of dopamine beta hydroxylase (Dbh) gene on blood pressure in spontaneously hypertensive rats. Physiol Res. 2016 Dec 13; 65(6):1039-1044. PMID: 27959576.
      View in: PubMed
    3. Biswas N, Maihofer AX, Mir SA, Rao F, Zhang K, Khandrika S, Mahata M, Friese RS, Hightower CM, Mahata SK, Baker DG, Nievergelt CM, Vaingankar S, O'Connor DT. Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system. BMC Med Genet. 2016 Mar 11; 17:21. PMID: 26969407; PMCID: PMC4788869.
    4. Mir SA, Zhang K, Milic M, Gu Y, Rieg T, Ziegler M, Vaingankar S. Analysis and validation of traits associated with a single nucleotide polymorphism Gly364Ser in catestatin using humanized chromogranin A mouse models. J Hypertens. 2016 Jan; 34(1):68-78. PMID: 26556564.
      View in: PubMed
    5. Zhang K, Mir SA, Hightower CM, Miramontes-Gonzalez JP, Maihofer AX, Chen Y, Mahata SK, Nievergelt CM, Schork NJ, Freedman BI, Vaingankar S, O'Connor DT. Molecular Mechanism for Hypertensive Renal Disease: Differential Regulation of Chromogranin A Expression at 3'-Untranslated Region Polymorphism C+87T by MicroRNA-107. J Am Soc Nephrol. 2015 Aug; 26(8):1816-25. PMID: 25392232; PMCID: PMC4520173.
    6. Dev NB, Mir SA, Gayen JR, Siddiqui JA, Mustapic M, Vaingankar S. Cardiac electrical activity in a genomically "humanized" chromogranin a monogenic mouse model with hyperadrenergic hypertension. J Cardiovasc Transl Res. 2014 Jul; 7(5):483-493. PMID: 24821335; PMCID: PMC4101044.
    7. Zhang K, Biswas N, Gayen JR, Miramontes-Gonzalez JP, Hightower CM, Mustapic M, Mahata M, Huang CT, Hook VY, Mahata SK, Vaingankar S, O'Connor DT. Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms. J Neurochem. 2014 Apr; 129(1):48-59. PMID: 24266713; PMCID: PMC3992281.
    8. Friese RS, Altshuler AE, Zhang K, Miramontes-Gonzalez JP, Hightower CM, Jirout ML, Salem RM, Gayen JR, Mahapatra NR, Biswas N, Cale M, Vaingankar S, Kim HS, Courel M, Taupenot L, Ziegler MG, Schork NJ, Pravenec M, Mahata SK, Schmid-Schönbein GW, O'Connor DT. MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension. Hum Mol Genet. 2013 Sep 15; 22(18):3624-40. PMID: 23674521; PMCID: PMC3749858.
    9. Zhang K, Chen Y, Wen G, Mahata M, Rao F, Fung MM, Vaingankar S, Biswas N, Gayen JR, Friese RS, Mahata SK, Hamilton BA, O'Connor DT. Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension. Curr Hypertens Rep. 2011 Feb; 13(1):36-45. PMID: 21104344; PMCID: PMC3016145.
    10. Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar S, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton BA, O'Connor DT. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cell Mol Neurobiol. 2010 Nov; 30(8):1395-400. PMID: 21061160; PMCID: PMC3008929.
    11. Vaingankar S, Li Y, Biswas N, Gayen J, Choksi S, Rao F, Ziegler MG, Mahata SK, O'Connor DT. Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses. J Hypertens. 2010 Apr; 28(4):817-25. PMID: 20139771; PMCID: PMC2947860.
    12. Vaingankar S, Li Y, Corti A, Biswas N, Gayen J, O'Connor DT, Mahata SK. Long human CHGA flanking chromosome 14 sequence required for optimal BAC transgenic "rescue" of disease phenotypes in the mouse Chga knockout. Physiol Genomics. 2010 Mar 03; 41(1):91-101. PMID: 20009010; PMCID: PMC2841496.
    13. Gayen JR, Saberi M, Schenk S, Biswas N, Vaingankar S, Cheung WW, Najjar SM, O'Connor DT, Bandyopadhyay G, Mahata SK. A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. J Biol Chem. 2009 Oct 16; 284(42):28498-509. PMID: 19706599; PMCID: PMC2781393.
    14. Biswas N, Rodriguez-Flores JL, Courel M, Gayen JR, Vaingankar S, Mahata M, Torpey JW, Taupenot L, O'Connor DT, Mahata SK. Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides. Endocrinology. 2009 Aug; 150(8):3547-57. PMID: 19372204; PMCID: PMC2717865.
    15. Zhang K, Rao F, Rana BK, Gayen JR, Calegari F, King A, Rosa P, Huttner WB, Stridsberg M, Mahata M, Vaingankar S, Mahboubi V, Salem RM, Rodriguez-Flores JL, Fung MM, Smith DW, Schork NJ, Ziegler MG, Taupenot L, Mahata SK, O'Connor DT. Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B. Circ Cardiovasc Genet. 2009 Feb; 2(1):46-56. PMID: 20011129.
      View in: PubMed
    16. Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar S, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT. Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. J Am Coll Cardiol. 2008 Oct 28; 52(18):1468-81. PMID: 19017515; PMCID: PMC2659417.
    17. Montero-Hadjadje M, Vaingankar S, Elias S, Tostivint H, Mahata SK, Anouar Y. Chromogranins A and B and secretogranin II: evolutionary and functional aspects. Acta Physiol (Oxf). 2008 Feb; 192(2):309-24. PMID: 18005393.
      View in: PubMed
    18. Biswas N, Vaingankar S, Mahata M, Das M, Gayen JR, Taupenot L, Torpey JW, O'Connor DT, Mahata SK. Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin. Endocrinology. 2008 Feb; 149(2):749-57. PMID: 17991725; PMCID: PMC2219303.
    19. Zhang L, Rao F, Zhang K, Khandrika S, Das M, Vaingankar S, Bao X, Rana BK, Smith DW, Wessel J, Salem RM, Rodriguez-Flores JL, Mahata SK, Schork NJ, Ziegler MG, O'Connor DT. Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk. J Clin Invest. 2007 Sep; 117(9):2658-71. PMID: 17717598; PMCID: PMC1950457.
    20. Mosley CA, Taupenot L, Biswas N, Taulane JP, Olson NH, Vaingankar S, Wen G, Schork NJ, Ziegler MG, Mahata SK, O'Connor DT. Biogenesis of the secretory granule: chromogranin A coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation. Biochemistry. 2007 Sep 25; 46(38):10999-1012. PMID: 17718510.
      View in: PubMed
    21. Rao F, Wen G, Gayen JR, Das M, Vaingankar S, Rana BK, Mahata M, Kennedy BP, Salem RM, Stridsberg M, Abel K, Smith DW, Eskin E, Schork NJ, Hamilton BA, Ziegler MG, Mahata SK, O'Connor DT. Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension. Circulation. 2007 May 01; 115(17):2271-81. PMID: 17438154.
      View in: PubMed
    22. Zhang K, Rao F, Wen G, Salem RM, Vaingankar S, Mahata M, Mahapatra NR, Lillie EO, Cadman PE, Friese RS, Hamilton BA, Hook VY, Mahata SK, Taupenot L, O'Connor DT. Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin. Diabetes Obes Metab. 2006 Nov; 8(6):621-33. PMID: 17026486.
      View in: PubMed
    23. Mahapatra NR, O'Connor DT, Vaingankar S, Hikim AP, Mahata M, Ray S, Staite E, Wu H, Gu Y, Dalton N, Kennedy BP, Ziegler MG, Ross J, Mahata SK. Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest. 2005 Jul; 115(7):1942-52. PMID: 16007257; PMCID: PMC1159140.
    24. Prommegger R, Ensinger C, Adlassnig C, Vaingankar S, Mahata SK, Marksteiner J, Margreiter R. Catestatin--a novel neuropeptide in carcinoid tumors of the appendix. Anticancer Res. 2004 Jan-Feb; 24(1):311-6. PMID: 15015613.
      View in: PubMed
    25. Vaingankar S, Fitzpatrick TA, Johnson K, Goding JW, Maurice M, Terkeltaub R. Subcellular targeting and function of osteoblast nucleotide pyrophosphatase phosphodiesterase 1. Am J Physiol Cell Physiol. 2004 May; 286(5):C1177-87. PMID: 15075217.
      View in: PubMed
    26. Rutsch F, Ruf N, Vaingankar S, Toliat MR, Suk A, Höhne W, Schauer G, Lehmann M, Roscioli T, Schnabel D, Epplen JT, Knisely A, Superti-Furga A, McGill J, Filippone M, Sinaiko AR, Vallance H, Hinrichs B, Smith W, Ferre M, Terkeltaub R, Nürnberg P. Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Nat Genet. 2003 Aug; 34(4):379-81. PMID: 12881724.
      View in: PubMed
    27. Rutsch F, Vaingankar S, Johnson K, Goldfine I, Maddux B, Schauerte P, Kalhoff H, Sano K, Boisvert WA, Superti-Furga A, Terkeltaub R. PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am J Pathol. 2001 Feb; 158(2):543-54. PMID: 11159191; PMCID: PMC1850320.
    28. Johnson KA, Hessle L, Vaingankar S, Wennberg C, Mauro S, Narisawa S, Goding JW, Sano K, Millan JL, Terkeltaub R. Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1. Am J Physiol Regul Integr Comp Physiol. 2000 Oct; 279(4):R1365-77. PMID: 11004006.
      View in: PubMed
    29. Johnson K, Vaingankar S, Chen Y, Moffa A, Goldring MB, Sano K, Jin-Hua P, Sali A, Goding J, Terkeltaub R. Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Arthritis Rheum. 1999 Sep; 42(9):1986-97. PMID: 10513816.
      View in: PubMed
    Sucheta's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _